﻿FN Clarivate Analytics Web of Science
VR 1.0
PT J
AU Zhang, B
   Wang, Y
   Li, H
   Xiong, R
   Zhao, ZB
   Chu, XK
   Li, QQ
   Sun, SY
   Chen, SD
AF Zhang, Bei
   Wang, Ying
   Li, Hui
   Xiong, Ran
   Zhao, Zongbo
   Chu, Xingkun
   Li, Qiongqiong
   Sun, Suya
   Chen, Shengdi
TI Neuroprotective effects of salidroside through PI3K/Akt pathway
   activation in Alzheimer's disease models
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Article
DE Alzheimer's disease; amyloid-beta; salidroside; Drosophila;
   neuroprotective effect
ID COGNITIVE DEFICITS; SIGNALING PATHWAY; OXIDATIVE STRESS; RAT MODEL;
   EXPRESSION; ACCUMULATION; DROSOPHILA; PROTECTS; NEUROGENESIS; TOXICITY
AB Alzheimer's disease (AD) is a devastating neurodegenerative disorder characterized by deposits of aggregated amyloid-beta(A beta) peptide and neurofibrillary tangles in the brain parenchyma. Despite considerable research to elucidate the pathological mechanisms and identify therapeutic strategies for AD, effective treatments are still lacking. In the present study, we found that salidroside (Sal), a phenylpropanoid glycoside isolated from Rhodiola rosea L., can protect against A beta-induced neurotoxicity in four transgenic Drosophila AD models. Both longevity and locomotor activity were improved in Sal-fed Drosophila. Sal also decreased A beta-levels and A beta deposition in brain and ameliorated toxicity in A beta-treated primary neuronal culture. The neuroprotective effect of Sal was associated with upregulated phosphatidylinositide 3-kinase (PI3K)/Akt signaling. Our findings identify a compound that may possess potential therapeutic benefits for AD and other forms of neurodegeneration.
C1 [Zhang, Bei; Wang, Ying; Li, Hui; Xiong, Ran; Zhao, Zongbo; Li, Qiongqiong; Sun, Suya; Chen, Shengdi] Shanghai Jiao Tong Univ, Sch Med, Inst Neurol, Ruijin Hosp,Dept Neurol, 197 Rui Jin Er Rd, Shanghai 200025, Peoples R China.
   [Zhang, Bei; Chu, Xingkun; Chen, Shengdi] Shanghai Jiao Tong Univ, Chinese Acad Sci, Shanghai Inst Biol Sci, Lab Neurodegenerat Dis,Inst Hlth Sci, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Chinese
   Academy of Sciences
RP Sun, SY; Chen, SD (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Inst Neurol, Ruijin Hosp,Dept Neurol, 197 Rui Jin Er Rd, Shanghai 200025, Peoples R China.
EM sunsuya@shsmu.edu.cn; chen_sd@medmail.com.cn
FU National Natural Science Fund of China [81430022, 91332107]
FX The authors thank Dr Nan-Jie Xu for helpful comments on the manuscript,
   Dr Gang Pei for providing transgenic Drosophila, and Ilya Bezprozvanny
   for providing APPsw and tdTomato plasmids. This work was supported by
   grants from the National Natural Science Fund of China (81430022,
   91332107).
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NR 32
TC 86
Z9 95
U1 1
U2 41
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2016
VL 10
BP 1335
EP 1343
DI 10.2147/DDDT.S99958
PG 9
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DI5YE
UT WOS:000373575600001
PM 27103787
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Nuikin, SA
   Timchenko, YV
   Rodin, IA
AF Nuikin, S. A.
   Timchenko, Yu. V.
   Rodin, I. A.
TI Simultaneous Determination of Biologically Active Components of
   Rhodiola rosea in Extracts of Plant Raw Materials by HILIC-MS/MS
SO JOURNAL OF ANALYTICAL CHEMISTRY
LA English
DT Article
DE hydrophilic chromatography; tandem mass spectrometry; analysis of plant
   raw material
ID SALIDROSIDE; TYROSOL; L.
AB A simple, rapid, and highly sensitive method for the simultaneous determination of the main components of Rhodiola rosea (rosin, salidroside, rosarin, and rosavin) in a wide concentration range by hydrophilic chromatography-tandem mass spectrometry is developed. The conditions for the extraction (extractant type and composition, extraction time) of the main components from Rhodiola rosea root samples, chromatographic separation and detection of these compounds are selected, and the performance characteristics of the proposed approach are evaluated. The limits of detection are 250, 2.4, 2.3, and 5.4 ng/mL, and the linearity ranges are 1-100, 0.01-10, 0.01-10, and 0.01-100 mu g/mL for rosin, salidroside, rosarin and rosavin, respectively. The developed approach is tested in an analysis of real samples of the pharmaceutical product and of plant raw material.
C1 [Nuikin, S. A.; Timchenko, Yu. V.; Rodin, I. A.] Lomonosov Moscow State Univ, Dept Chem, Moscow 119991, Russia.
C3 Lomonosov Moscow State University
RP Timchenko, YV (corresponding author), Lomonosov Moscow State Univ, Dept Chem, Moscow 119991, Russia.
EM yury_tim@mail.ru
RI Rodin, Igor/M-3359-2016; Timchenko, Yury/JGC-8865-2023
FU Lomonosov Moscow State University [AAAA-A21-121011590089-1]; Moscow
   University Development Program
FX This work was carried out using funds from the state assignment
   "Development of highly informative and high-tech methods of chemical
   analysis for the protection of ecosystems, creation of new materials and
   advanced production technologies, transition to environmentally friendly
   and resource-saving energy, development of nature-like technologies,
   high-tech healthcare and rational nature management" (CITIS number:
   AAAA-A21-121011590089-1) of Lomonosov Moscow State University. No
   additional grants were obtained to carry out or direct this particular
   research. HPLC-MS studies were performed using equipment purchased with
   funds from the Moscow University Development Program.
CR Alperth F, 2019, SCI PHARM, V87, DOI 10.3390/scipharm87020008
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NR 12
TC 1
Z9 1
U1 3
U2 7
PU PLEIADES PUBLISHING LTD
PI TORTOLA
PA TROPIC ISLE BLDG, PO BOX 3331. ROAD TOWN, TORTOLA, BRITISH VIRGIN ISL
SN 1061-9348
EI 1608-3199
J9 J ANAL CHEM+
JI J. Anal. Chem.
PD FEB
PY 2025
VL 80
IS 2
BP 267
EP 278
DI 10.1134/S1061934824701740
PG 12
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 1TB8F
UT WOS:001472997600018
DA 2026-05-27
ER

PT J
AU Chen, L
   Hu, YD
   Li, N
   Zong, MH
AF Chen, Lei
   Hu, Ying-Dan
   Li, Ning
   Zong, Min-Hua
TI Cross-linked enzyme aggregates of β-glucosidase from Prunus
   domestica seeds
SO BIOTECHNOLOGY LETTERS
LA English
DT Article
DE Cross-linked enzyme aggregates; beta-Glucosidase; Glycosylation; Enzyme
   immobilization; Salidroside; Reverse hydrolysis
ID OPTIMIZATION; SALIDROSIDE; GLYCOSIDES; CLEAS
AB Cross-linked enzyme aggregates (CLEAs) of beta-glucosidase were prepared and characterized. Under the optimum conditions, the activity recovery of CLEAs reached 84 %. The reduction by NaBH4 resulted in slightly lower activities of CLEAs, while their thermostability was enhanced. CLEAs were more thermally stable than free enzyme (half lives, 973 vs. 518 min at 50 A degrees C), while less stable than seed meal (half life, 1,090 min). In 90 % (v/v) t-butanol, the half lives of CLEAs and free enzyme were 53 and 6.7 h, respectively. Besides, the catalytic efficiency (V (max)/K (m)) of CLEAs was comparable to free enzyme (0.42 vs. 0.47 min(-1) mg(-1)). This carrier-free immobilized enzyme had a network structure with multiple layers. The productivity of salidroside using CLEAs reached 150 g/l g catalyst, while being 6.3 g/l g with seed meal.
C1 [Chen, Lei; Li, Ning; Zong, Min-Hua] S China Univ Technol, State Key Lab Pulp & Paper Engn, Coll Light Ind & Food Sci, Guangzhou 510640, Guangdong, Peoples R China.
   [Hu, Ying-Dan] S China Univ Technol, Coll Biosci & Bioengn, Guangzhou 510006, Guangdong, Peoples R China.
C3 South China University of Technology; South China University of
   Technology
RP Li, N (corresponding author), S China Univ Technol, State Key Lab Pulp & Paper Engn, Coll Light Ind & Food Sci, Guangzhou 510640, Guangdong, Peoples R China.
EM lining@scut.edu.cn; btmhzong@scut.edu.cn
RI Li, Ning/I-3417-2012
OI Li, Ning/0000-0003-1684-4454
FU National Natural Science Foundation of China [20906032, 21072065];
   Research Fund for the Doctoral Program of Higher Education
   [20090172110019]
FX This research was financially supported by the National Natural Science
   Foundation of China (20906032 and 21072065), and the Research Fund for
   the Doctoral Program of Higher Education (20090172110019).
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NR 21
TC 13
Z9 14
U1 0
U2 50
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0141-5492
J9 BIOTECHNOL LETT
JI Biotechnol. Lett.
PD SEP
PY 2012
VL 34
IS 9
BP 1673
EP 1678
DI 10.1007/s10529-012-0947-y
PG 6
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA 998JQ
UT WOS:000308234400011
PM 22618237
DA 2026-05-27
ER

PT J
AU Chyba, A
   Mastihuba, V
   Mastihubová, M
AF Chyba, Andrej
   Mastihuba, Vladimir
   Mastihubova, Maria
TI Effective enzymatic caffeoylation of natural glucopyranosides
SO BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
LA English
DT Article
DE Regioselective caffeoylation; Lipozyme TL IM; Robustaside B;
   6-O-Caffeoyl-salidroside; Phenylpropanoid glycosides
ID ACID PHENETHYL ESTER; CAFFEIC ACID; PHENOLIC GLYCOSIDES; FERULIC ACID;
   CLASSIFICATION; SPECIFICITY; ACYLATION
AB Reaction system was developed for enzymatic caffeoylation of model saccharidic acceptor methyl beta-D-glucopyranoside to obtain exclusively methyl 6-O-caffeoyl-beta-D-glucopyranoside. Reaction with starting concentration of acceptor 0.2 M provided 73% yield of purified product within 17 days. Reactions with low acceptor concentrations (0.04 and 0.08 M) run to the completion within 7 days. Such highly effective and regioselective reaction was promoted by Lipozyme TL IM in tert-butanol, using vinyl caffeate as acylation donor. The optimized reaction conditions were used in preparative caffeoylation of natural substances-arbutin and salidroside, giving 75% of 6-O-caffeoylated arbutin (robustaside B) and 74% of 6-O-caffeoylated salidroside as the only products after 12 and 16 days, respectively. (C) 2016 Elsevier Ltd. All rights reserved.
C1 [Chyba, Andrej; Mastihuba, Vladimir; Mastihubova, Maria] Slovak Acad Sci, Lab Biocatalysis & Organ Synth, Inst Chem, Dubravska Cesta 9, SK-84538 Bratislava, Slovakia.
C3 Slovak Academy of Sciences; Institute of Chemistry, SAS
RP Mastihubová, M (corresponding author), Slovak Acad Sci, Lab Biocatalysis & Organ Synth, Inst Chem, Dubravska Cesta 9, SK-84538 Bratislava, Slovakia.
EM chemjama@savba.sk
RI Mastihubova, Maria/OZG-0746-2025; Mastihuba, Vladimír/S-7938-2017
OI Mastihubova, Maria/0000-0003-3033-811X; Mastihuba,
   Vladimír/0000-0003-2587-2553
FU Slovak Research and Development Agency [APVV-0846-12]; Slovak Grant
   Agency for Science VEGA [2/0138/12]; Research & Development Operational
   Programme - ERDF [26240120001, 26240120025]
FX This work was supported by the Slovak Research and Development Agency
   under the contract No. APVV-0846-12. This publication is also the result
   of the grant from the Slovak Grant Agency for Science VEGA under the
   Project No. 2/0138/12 and of the projects implementation 'Centre of
   Excellence on Green Chemistry Methods and Processes (CEGreenI, contract
   No. 26240120001)' and 'Amplification of the Centre of Excellence on
   Green Chemistry Methods and Processes (CEGreenII, contract No.
   26240120025)' supported by the Research & Development Operational
   Programme funded by the ERDF.
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NR 34
TC 10
Z9 10
U1 0
U2 50
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0960-894X
EI 1464-3405
J9 BIOORG MED CHEM LETT
JI Bioorg. Med. Chem. Lett.
PD MAR 15
PY 2016
VL 26
IS 6
BP 1567
EP 1570
DI 10.1016/j.bmcl.2016.02.010
PG 4
WC Chemistry, Medicinal; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA DF0HC
UT WOS:000371018800015
PM 26896186
DA 2026-05-27
ER

PT J
AU Tu, ZL
   Zhang, ZY
   Jin, PP
   Yang, HL
   Li, C
   Xi, Y
   Guo, ZM
   Hou, SX
   Li, WW
AF Tu, Zhilan
   Zhang, Zengyu
   Jin, Pengpeng
   Yang, Hualan
   Li, Chao
   Xi, Yan
   Guo, Zimin
   Hou, Shuangxing
   Li, Weiwei
TI Salidroside promotes pro-angiogenesis and repair of blood brain barrier
   via Notch/ITGB1 signal path in CSVD Model
SO JOURNAL OF ADVANCED RESEARCH
LA English
DT Article
DE Salidroside; CSVD; Blood brain barrier; Notch signal pathway; ITGB1
ID ENDOTHELIAL-CELLS; RAT MODEL; VESSEL; BETA-1-INTEGRIN; DYSFUNCTION;
   EXPRESSION
AB Introduction: Salidroside (SAL), extracted from Rhodiola rosea, has been widely used in coronary heart disease and myocardial ischemia for decades. Previous studies have demonstrated that SAL could reduce arteriosclerosis, and thus combat ischemic brain damage. However, the in-depth function of the salidroside in Cerebral Small Vascular Disease (CSVD) has not been discovered, and related molecular mechanism is still unclear. Objectives: The present study aims to explore the effects of salidroside in angiogenesis as well as repair of blood brain barrier (BBB) and its possible mechanisms. Methods: We established a rat model of SHR via 2-vessel gradual occlusion (SHR-2VGO) to mimic the CSVD. Subsequently, the MRI, pathomorphism, as well as Morriss water maze test were conducted to determine CSVD-related indicators. 8 weeks post-surgery, animals were randomly administered SAL, DAPT, ATN161 or saline.The aim was to explore the protective effects of SAL in CSVD as well as its possible mechanism. Results: Here we found that SAL could attenuate cerebral hypoperfusion-induced BBB disruption, promote the pro-angiogenesis through enhancing the cell budding. Further investigations demonstrated that SAL could significantly increase the expression of Notch1, Hes1, Hes5, and ITGB1. In addition, we confirmed that SAL could activate Notch signal path, and then up-regulate ITGB1 to promote proangiogenesis and thus protect BBB from disruption. Conclusion: The aforementioned findings demonstrated that SAL could protect BBB integrity through Notch-ITGB1 signaling path in CSVD, which indicated that SAL could be a potential medicine candidate for CSVD treatment. (c) 2024 Production and hosting by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Li, Weiwei] Fudan Univ, Childrens Hosp, Inst Pediat, Shanghai 201102, Peoples R China.
   [Tu, Zhilan; Zhang, Zengyu; Yang, Hualan; Guo, Zimin; Hou, Shuangxing] Fudan Univ, Shanghai Pudong Hosp, Pudong Med Ctr, Dept Neurol, Shanghai 201399, Peoples R China.
   [Jin, Pengpeng] Fudan Univ, Shanghai Pudong Hosp, Pudong Med Ctr, Dept Chron Dis Management, Shanghai 201399, Peoples R China.
   [Zhang, Zengyu] Fudan Univ, Shanghai Med Coll, Shanghai 200032, Peoples R China.
   [Li, Chao] Change Cty Hosp Tradit Chinese Med, Vasculocardiol Dept, Changyi 261300, Shandong, Peoples R China.
   [Xi, Yan] Shanghai TCM Integrated Hosp, Dept Radiol, Shanghai 200082, Peoples R China.
C3 Fudan University; Fudan University; Fudan University; Fudan University
RP Hou, SX (corresponding author), 2800 Gongwei Rd, Shanghai 201399, Peoples R China.; Li, WW (corresponding author), Wanyuan Rd 399, Shanghai, Peoples R China.
EM housx021@163.com; wei261206@163.com
RI Hou, Shuangxing/LLL-2736-2024; Zhang, Zengyu/LJL-3632-2024
OI Zhang, Zengyu/0000-0002-2751-3901
FU Key Discipline Project of Shanghai Pudong Hospital [zdxk2020-09];
   Science and Technology Development Fund of Shanghai Pudong New Area
   [PKJ2020-Y51]; Health Technology Project of Shanghai Pudong New Area
   [PW2023A-76]; Project of Key Medical Specialty and Treatment Center of
   Pudong Hospital of Fudan University [Tszb2020-14]; Shanghai
   Interna-tional Science and Technology Cooperation Fund Project
   [18410742100]; Research and Promotion of Interven-tion Techniques for
   High-risk Groups of Stroke in China [GN-2018R0008]
FX This study was supported by the Key Discipline Project of Shanghai
   Pudong Hospital, No. zdxk2020-09 (to LYX); The Science and Technology
   Development Fund of Shanghai Pudong New Area, No. PKJ2020-Y51 (to TZL),
   The Health Technology Project of Shanghai Pudong New Area, No.
   PW2023A-76 (to HSX), the Project of Key Medical Specialty and Treatment
   Center of Pudong Hospital of Fudan University, No. Tszb2020-14 (to YHL),
   The Shanghai International Science and Technology Cooperation Fund
   Project, No. 18410742100 (to HSX); The Research and Promotion of
   Intervention Techniques for High-risk Groups of Stroke in China, No.
   GN-2018R0008 (to HSX).
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NR 50
TC 30
Z9 31
U1 8
U2 46
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2090-1232
EI 2090-1224
J9 J ADV RES
JI J. Adv. Res.
PD FEB
PY 2025
VL 68
BP 429
EP 444
DI 10.1016/j.jare.2024.02.019
EA JAN 2025
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA W1Z2K
UT WOS:001416633300001
PM 38417575
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wu, Y
   Ma, Y
   Li, J
   Zhou, XL
   Li, L
   Xu, PX
   Li, XR
   Xue, M
AF Wu Yi
   Ma Yi
   Li Jing
   Zhou Xue-Lin
   Li Lei
   Xu Ping-Xiang
   Li Xiao-Rong
   Xue Ming
TI The bioinformatics and metabolomics research on anti-hypoxic molecular
   mechanisms of Salidroside via regulating the PTEN mediated
   PI3K/Akt/NF-κB signaling pathway
SO CHINESE JOURNAL OF NATURAL MEDICINES
LA English
DT Article
DE Salidroside; Hypoxia; PC12; Metabolomics; PTEN; PI3K/Akt/NF-kappa B
ID KAPPA-B; HYPOXIA; APOPTOSIS; CANCER; ACTIVATION; INJURY; MITOCHONDRIA;
   INFLAMMATION; RELEVANCE; EXPOSURE
AB Salidroside (SAL), a major bioactive compound of Rhodiola crenulata, has significant anti-hypoxia effect, however, its underlying molecular mechanism has not been elucidated. In order to explore the protective mechanism of SAL, the lactate dehydrogenase (LDH), reactive oxygen species (ROS), superoxide dismutase (SOD) and hypoxia-induced factor 1 alpha (HIF-1 alpha) were measured to establish the PC12 cell hypoxic model. Cell staining and cell viability analyses were performed to evaluate the protective effects of SAL. The metabolomics and bioinformatics methods were used to explore the protective effects of salidroside under hypoxia condition. The metabolite-protein interaction networks were further established and the protein expression level was examined by Western blotting. The results showed that 59 endogenous metabolites changed and the expression of the hub proteins of CK2, p-PTEN/PTEN, PI3K, p-Akt/Akt, NF-kappa B p65 and Bcl-2 were increased, suggesting that SAL could increase the expression of CK2, which induced the phosphorylation and inactivation of PTEN, reduced the inhibitory effect on PI3K signaling pathways and activated the PI3K/Akt/NF-kappa B survival signaling pathway. Our study provided an important insight to reveal the protective molecular mechanism of SAL as a novel drug candidate.
C1 [Wu Yi; Ma Yi; Li Jing; Zhou Xue-Lin; Xu Ping-Xiang; Li Xiao-Rong; Xue Ming] Capital Med Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing Lab Biomed Detect Technol & Instrument, Beijing 100069, Peoples R China.
   [Zhou Xue-Lin; Xu Ping-Xiang; Li Xiao-Rong; Xue Ming] Beijing Engn Res Ctr Nerve Syst Drugs, Beijing 100053, Peoples R China.
   [Li Lei] Capital Med Univ, Cent Lab, Beijing 100069, Peoples R China.
C3 Capital Medical University; Capital Medical University
RP Li, XR; Xue, M (corresponding author), Capital Med Univ, Sch Basic Med Sci, Dept Pharmacol, Beijing Lab Biomed Detect Technol & Instrument, Beijing 100069, Peoples R China.; Li, XR; Xue, M (corresponding author), Beijing Engn Res Ctr Nerve Syst Drugs, Beijing 100053, Peoples R China.
EM madingdaier@aliyun.com; xuem@ccmu.edu.cn
RI Zhou, Xuelin/L-4359-2013; LI, Jing/HDN-1497-2022
OI Zhou, Xuelin/0000-0002-4051-7851; 
FU National Natural Science Foundation of China [81573683, 81173121,
   81773803]
FX This work was supported by the National Natural Science Foundation of
   China (Nos. 81573683, 81173121 and 81773803).
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TC 14
Z9 19
U1 7
U2 64
PU CHINESE JOURNAL NATURAL MEDICINES
PI NANJING
PA 24, TONGJIA XIANG, NANJING, 210009, PEOPLES R CHINA
SN 2095-6975
EI 1875-5364
J9 CHIN J NAT MEDICINES
JI Chin. J. Nat. Med.
PD JUN
PY 2021
VL 19
IS 6
BP 442
EP 453
DI 10.1016/S1875-5364(21)60043-2
EA JUN 2021
PG 12
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA SO7RS
UT WOS:000659173300005
PM 34092295
DA 2026-05-27
ER

PT J
AU Zhang, YY
   Ge, HF
   Yu, YL
   Gao, H
   Fan, XL
   Li, Q
   Zhou, ZL
AF Zhang, Yanyan
   Ge, Hongfan
   Yu, Yaling
   Gao, Hang
   Fan, Xiaoli
   Li, Qiao
   Zhou, Zhenlei
TI Dietary salidroside supplementation improves meat quality and
   antioxidant capacity and regulates lipid metabolism in broilers
SO FOOD CHEMISTRY-X
LA English
DT Article
DE Salidroside; Meat quality; Antioxidant capacity; Freeze -thaw cycles;
   Lipid metabolism
ID CORONARY-HEART-DISEASE; BREAST; INFLAMMATION; PRODUCTS
AB We aimed to explore the effect of salidroside (SAL) on meat quality, antioxidant capacity, and lipid metabolism in broilers. The results demonstrated that SAL significantly reduced the yellowness (b*), shear force, cooking loss, drip loss, MDA, TBARS, and carbonyl content in breast (P < 0.05), while increasing the pH value (P < 0.05), suggesting an improvement in meat quality. SAL lowered the lipid contents in liver and serum (P < 0.05), while increasing the proportion of unsaturated fatty acids in breast (P < 0.05), indicating effective regulation of lipid metabolism by SAL. SAL increased the activity of antioxidant enzymes and the expression of antioxidant genes in both liver and muscle (P < 0.05). Additionally, SAL improved the meat quality and antioxidant capacity of breast subjected to repeated freeze-thaw treatment. SAL may enhance meat quality by improving antioxidative stability and regulating lipid metabolism, potentially serving as a dietary supplement for broilers.
C1 [Zhang, Yanyan; Ge, Hongfan; Yu, Yaling; Gao, Hang; Fan, Xiaoli; Li, Qiao; Zhou, Zhenlei] Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China.
C3 Nanjing Agricultural University
RP Zhou, ZL (corresponding author), Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China.
EM 2022007088@stu.njau.edu.cn; 2022207022@stu.njau.edu.cn;
   2020207037@stu.njau.edu.cn; 2022107088@stu.njau.edu.cn;
   liqiao@njau.edu.cn; zhouzl@njau.edu.cn
RI fan, xiaoli/NJS-4489-2025; Ge, Hongfan/OFN-2437-2025
FU National Natural Science Foundation of China [32273080]
FX This work was supported by the National Natural Science Foundation of
   China (No. 32273080) . The authors would like to thank all the
   re-viewers who participated in the review, as well as MJEditor ( www.mje
   ditor.com ) for providing English editing services during the
   preparation of this manuscript.
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TC 15
Z9 19
U1 7
U2 34
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2590-1575
J9 FOOD CHEM X
JI Food Chem. X
PD JUN 30
PY 2024
VL 22
AR 101406
DI 10.1016/j.fochx.2024.101406
EA APR 2024
PG 13
WC Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology
GA RA0R4
UT WOS:001224840100001
PM 38707782
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, JF
   Li, ZQ
   Song, JB
   Zhou, L
   Chen, X
   Ge, W
   Dong, TY
   Luo, YX
   Mao, T
   Li, Z
   Tan, D
   Rasmussen, LJ
   Bohr, VA
   Tong, XL
   Dai, FY
AF Zhang, Jianfei
   Li, Zhiquan
   Song, Jiangbo
   Zhou, Lei
   Chen, Xin
   Ge, Wen
   Dong, Tianyi
   Luo, Yuxin
   Mao, Ting
   Li, Zheng
   Tan, Duan
   Rasmussen, Lene Juel
   Bohr, Vilhelm A.
   Tong, Xiaoling
   Dai, Fangyin
TI Salidroside promotes healthy longevity by interfering with HSP90
   activity
SO GEROSCIENCE
LA English
DT Article
DE Rhodiola rosea; Salidroside; Aging; Lifespan; Drug target
   identification; HSP90
ID LIFE-SPAN; SEX-DIFFERENCES; STRESS; INHIBITION; ELEGANS
AB Aging is a risk factor for human health and quality of life. Screening and development of novel supplements and medications to combat aging and delay the incidence of age-related diseases are of great significance. In this study, salidroside (SA), a primary natural small molecule from Rhodiola rosea, was investigated regarding its effects on life and healthspan and the underlying molecular mechanism(s) of anti-aging and antioxidation. Our results showed that SA effectively prolonged lifespan and exhibited anti-aging and antioxidative properties. Computer-assisted methods, label-free interaction analysis, and in vitro assays showed that SA directly bound heat shock protein 90 (HSP90). Furthermore, SA significantly inhibited the ATPase activity of HSP90, affecting the interaction between HSP90 and its interacting proteins and the expression of downstream genes to regulate lifespan and the oxidative stress response. Our findings provided new insights into the pharmacological properties of SA across multiple species and its potential as an anti-aging drug.
C1 [Zhang, Jianfei; Song, Jiangbo; Zhou, Lei; Chen, Xin; Ge, Wen; Dong, Tianyi; Luo, Yuxin; Mao, Ting; Li, Zheng; Tan, Duan; Tong, Xiaoling; Dai, Fangyin] Southwest Univ, Coll Sericulture Text & Biomass Sci, Key Lab Sericulture Biol & Genet Breeding, Minist Agr & Rural Affairs,State Key Lab Resource, Chongqing 400715, Peoples R China.
   [Li, Zhiquan; Rasmussen, Lene Juel; Bohr, Vilhelm A.] Univ Copenhagen, Ctr Hlth Aging, Dept Cellular & Mol Med, DK-2200 Copenhagen, Denmark.
   [Bohr, Vilhelm A.] NIA, Sect DNA Repair, NIH, Baltimore, MD 21224 USA.
C3 Southwest University - China; University of Copenhagen; National
   Institutes of Health (NIH) - USA; NIH National Institute on Aging (NIA)
RP Dai, FY (corresponding author), Southwest Univ, Coll Sericulture Text & Biomass Sci, Key Lab Sericulture Biol & Genet Breeding, Minist Agr & Rural Affairs,State Key Lab Resource, Chongqing 400715, Peoples R China.
EM fydai@swu.edu.cn
RI Li, Zhiquan/IQW-1987-2023; Song, Jiangbo/HLQ-3918-2023; Dong,
   Tianyi/KVB-2372-2024; Bohr, Vilhelm/AAP-5931-2020
OI Li, Zhiquan/0000-0003-3253-7606; 
FU National Natural Science Foundation of China (NSFC) [31830094,
   32272939]; Fundamental Research Funds for the central Universities
   [SWU120011]; National Natural Science Foundation of China [32000810];
   NSFC [U20A2058]; Funds of China Agriculture Research System of MOF and
   MARA from the Ministry of Agriculture and Rural Affairs of the People's
   Republic of China [CARS-18-ZJ0102]
FX This project was supported by the National Natural Science Foundation of
   China (NSFC) to F. D. (No. 31830094) and to J. S. (No. 32272939),
   Fundamental Research Funds for the central Universities to L. Z.
   (SWU120011), National Natural Science Foundation of China to L. Z. (No.
   32000810), and No. U20A2058 from NSFC to X. T. Additional support was
   provided by Funds of China Agriculture Research System of MOF and MARA
   CARS-18-ZJ0102 from the Ministry of Agriculture and Rural Affairs of the
   People's Republic of China to F. D
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NR 46
TC 9
Z9 11
U1 4
U2 25
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 2509-2715
EI 2509-2723
J9 GEROSCIENCE
JI GeroScience
PD APR
PY 2024
VL 46
IS 2
SI SI
BP 1641
EP 1655
DI 10.1007/s11357-023-00921-3
EA SEP 2023
PG 15
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA HC1C8
UT WOS:001068687400001
PM 37713088
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Nikolaichuk, H
   Studzinski, M
   Stankevic, M
   Choma, IM
AF Nikolaichuk, Hanna
   Studzinski, Marek
   Stankevic, Marek
   Choma, Irena M.
TI Qualitative and Quantitative Evaluation of Rosavin, Salidroside, and
   p-Tyrosol in Artic Root Products via TLC-Screening, HPLC-DAD, and NMR
   Spectroscopy
SO MOLECULES
LA English
DT Article
DE TLC-screening; HPLC-DAD; NMR; arctic root
ID RHODIOLA-ROSEA
AB Artic root is a well-known plant adaptogen with multipotential pharmacological properties. Thin-layer chromatography (TLC)-screening followed by diode-array high-performance liquid chromatography and nuclear magnetic resonance spectroscopy proved to be a reliable and convenient method for the simultaneous determination of the quality of various herbal raw materials and supplements. This combination allowed for comparing and differentiating arctic root samples as well as defining their authenticity. The study provided information on the chemical and biological properties of the seven chosen samples as well as qualitative and quantitative evaluation of the quality markers: rosavin, salidroside, and p-tyrosol. The absence of rosavin, salidroside, and p-tyrosol in three samples was detected using TLC screening and confirmed by HPLC-DAD and NMR. The paper highlighted the importance of quality control and strict regulation for herbal medicine supplements and preparations.
C1 [Nikolaichuk, Hanna; Choma, Irena M.] Marie Curie Sklodowska Univ, Fac Chem, Dept Chromatog, Mar Curie-Sklodowska Sq3, Lublin, Poland.
   [Nikolaichuk, Hanna] Med Univ Lublin, Fac Biomed, Dept Bioanalyt, Jaczewskiego St 8B, Lublin, Poland.
   [Studzinski, Marek] Marie Curie Sklodowska Univ, Fac Chem, Dept Phys Chem, Mar Curie Sklodowska Sq3, Lublin, Poland.
   [Stankevic, Marek] Marie Curie Sklodowska Univ, Inst Chem Sci, Fac Chem, Dept Organ Chem, Gliniana St 33, Lublin, Poland.
C3 Maria Curie-Sklodowska University; Medical University of Lublin; Maria
   Curie-Sklodowska University; Maria Curie-Sklodowska University
RP Nikolaichuk, H; Choma, IM (corresponding author), Marie Curie Sklodowska Univ, Fac Chem, Dept Chromatog, Mar Curie-Sklodowska Sq3, Lublin, Poland.; Nikolaichuk, H (corresponding author), Med Univ Lublin, Fac Biomed, Dept Bioanalyt, Jaczewskiego St 8B, Lublin, Poland.
EM hanna.nikolaichuk@mail.umcs.pl; irena.choma@mail.umcs.pl
RI ; Choma, Irena/AAG-9790-2021; Studziński, Marek/D-4824-2011; Stankevič,
   Marek/K-6078-2018
OI Nikolaichuk, Hanna/0000-0001-6292-483X; Choma,
   Irena/0000-0002-6878-3748; Studziński, Marek/0000-0001-8226-1922;
   Stankevič, Marek/0000-0003-2917-6774
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NR 17
TC 3
Z9 4
U1 1
U2 18
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD DEC
PY 2022
VL 27
IS 23
AR 8299
DI 10.3390/molecules27238299
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6X3UJ
UT WOS:000896341800001
PM 36500392
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lai, MC
   Lin, JG
   Pai, PY
   Lai, MH
   Lin, YM
   Yeh, YL
   Cheng, SM
   Liu, YF
   Huang, CY
   Lee, SD
AF Lai, Mei-Chih
   Lin, Jaung-Geng
   Pai, Pei-Ying
   Lai, Mei-Hsin
   Lin, Yueh-Min
   Yeh, Yu-Lan
   Cheng, Shiu-Min
   Liu, Yi-fan
   Huang, Chih-Yang
   Lee, Shin-Da
TI Protective effect of salidroside on cardiac apoptosis in mice with
   chronic intermittent hypoxia
SO INTERNATIONAL JOURNAL OF CARDIOLOGY
LA English
DT Article
DE Apoptotic; Caspase; Heart; Hypoxia; Low oxygen; Salidroside
ID MITOCHONDRIA-DEPENDENT PATHWAY; OBSTRUCTIVE SLEEP-APNEA; OBESE ZUCKER
   RATS; OXIDATIVE STRESS; CARDIOMYOBLAST APOPTOSIS;
   CARDIOVASCULAR-DISEASE; HYPOBARIC HYPOXIA; SHORT-TERM; FAMILY; CELLS
AB Background: The goal of this study is to determine if salidroside has protective effects on hypoxia-induced cardiac widely dispersed apoptosis in mice with severe sleep apnea model.
   Methods: Sixty-four C57BL/6 J mice 5-6 months of age were divided into four groups, i.e. Control group (21% O-2, 24 h per day, 8 weeks, n = 16); Hypoxia group (Hypoxia: 7% O-2 60 s, 20% O-2 alternating 60 s, 8 h per day, 8 weeks, n = 16); and Hypoxia + S10 and Hypoxia + S30 groups (Hypoxia for 1st 4 weeks, hypoxia pretreated 10 mg/kg and 30 mg/kg salidroside by oral gavage per day for 2nd 4 weeks, n = 16 and 16). The excised hearts from four groups were measured by the heart weight index, H&E staining, TUNEL-positive assays and Western blotting.
   Results: TUNEL-positive apoptotic cells in mice heart were less in Hypoxia + S10 and Hypoxia + S30 than those in the Hypoxia group. Compared with Hypoxia, the protein levels of Fas ligand, Fas death receptors, Fas-Associated Death Domain (FADD), activated caspase 8, and activated caspase 3 (Fas pathways) were decreased in Hypoxia + S10 and Hypoxia + S30. In the mitochondria pathway, the protein levels of BcLx, Bcl2, and Bid (anti-apoptotic Bcl2 family) in Hypoxia + S10 and Hypoxia+ S30 were more than those in Hypoxia. The protein levels of Bax, t-Bid, activated caspase 9, and activated caspase 3 were less in Hypoxia+ S10 and Hypoxia+ S30 than those in hypoxia.
   Conclusions: Our findings suggest that salidroside has protective effects on chronic intermittent hypoxia-induced Fas-dependent and mitochondria-dependent apoptotic pathways in mice hearts. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
C1 [Lai, Mei-Chih; Lin, Jaung-Geng; Huang, Chih-Yang] China Med Univ, Grad Inst Chinese Med, Taichung 404, Taiwan.
   [Pai, Pei-Ying] China Med Univ & Hosp, Grad Inst Clin Med Sci, Taichung, Taiwan.
   [Lai, Mei-Hsin] Hungkuang Univ, Dept Nursing, Coll Med & Nursing, Taichung, Taiwan.
   [Lin, Yueh-Min; Yeh, Yu-Lan] Changhua Christian Hosp, Dept Pathol, Changhua, Taiwan.
   [Lin, Yueh-Min; Yeh, Yu-Lan] Jen Jr Coll Med Nursing & Management, Dept Med Technol, Miaoli, Taiwan.
   [Cheng, Shiu-Min] Asia Univ, Dept Psychol, Taichung, Taiwan.
   [Liu, Yi-fan; Lee, Shin-Da] China Med Univ, Dept Phys Therapy, Taichung 404, Taiwan.
   [Liu, Yi-fan; Lee, Shin-Da] China Med Univ, Grad Inst Rehabil Sci, Taichung 404, Taiwan.
   [Huang, Chih-Yang] China Med Univ & Hosp, Grad Inst Basic Med Sci, Taichung, Taiwan.
   [Huang, Chih-Yang] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung, Taiwan.
   [Lee, Shin-Da] Asia Univ, Dept Healthcare Adm, Taichung, Taiwan.
   [Lee, Shin-Da] Shanghai Univ TCM, Sch Rehabil Med, Shanghai, Peoples R China.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; Hungkuang University; Changhua
   Christian Hospital; Asia University Taiwan; China Medical University
   Taiwan; China Medical University Taiwan; China Medical University
   Taiwan; China Medical University Hospital - Taiwan; Asia University
   Taiwan; Asia University Taiwan; Shanghai University of Traditional
   Chinese Medicine
RP Lee, SD (corresponding author), China Med Univ, Dept Phys Therapy, 91 Hsueh Shih Rd, Taichung 404, Taiwan.
EM shinda@mail.cmu.edu.tw
RI ; Lee, Shin-Da/Q-2798-2015; Huang, Chih-Yang/Q-4862-2016
OI Cheng, Shiu-Min/0000-0001-8510-077X; Lee, Shin-Da/0000-0002-8393-8349;
   Huang, Chih-Yang/0000-0003-2347-0411
FU National Science Council [NSC 98-2622-B-039-004-CC3, NSC
   102-2410-H-468-029]; China Medical University, Taiwan [CMU99-COL-21];
   Taiwan Department of Health Clinical Trial and Research Center of
   Excellence [DOH102-TD-B-111-004]; Shanghai Institute of Higher Education
   [2012-47]
FX The study is supported by the National Science Council (NSC
   98-2622-B-039-004-CC3; NSC 102-2410-H-468-029) and China Medical
   University (CMU99-COL-21), Taiwan. This study is also supported in part
   by the Taiwan Department of Health Clinical Trial and Research Center of
   Excellence (DOH102-TD-B-111-004). Research was supported by The Program
   for Professor of Special Appointment (Eastern Scholar, Honorary Chair
   Professor) at Shanghai Institute of Higher Education (No 2012-47).
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NR 38
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U1 0
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PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-5273
EI 1874-1754
J9 INT J CARDIOL
JI Int. J. Cardiol.
PD JUL 1
PY 2014
VL 174
IS 3
BP 565
EP 573
DI 10.1016/j.ijcard.2014.04.132
PG 9
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA AL6RV
UT WOS:000339261400031
PM 24825027
DA 2026-05-27
ER

PT J
AU Qiao, X
   Li, Y
   Wang, WM
   Xiao, YL
   Tian, T
   Wang, XB
   Luo, HB
   Chen, DL
   Meng, XL
   Zeng, XD
   Hong, XC
AF Qiao, Xue
   Li, Yang
   Wang, Wumei
   Xiao, Yuling
   Tian, Tian
   Wang, Xiaobo
   Luo, Haibin
   Chen, Deliang
   Meng, Xianli
   Zeng, Xiaodong
   Hong, Xuechuan
TI A near-infrared IIb fluorophore for in vivo imaging and image-guided
   therapy of ischemic stroke
SO DYES AND PIGMENTS
LA English
DT Article
DE Functional dyes; Near-infrared IIb imaging; Vascular imaging;
   Image-guided therapy; Salidroside
ID CEREBRAL-ARTERY OCCLUSION; SALIDROSIDE; MODEL; NM
AB Near-infrared II (NIR-II) functional dyes can diagnose various diseases in non-invasive conditions. Dynamic visualization of ischemic stroke has the potential to expedite stroke diagnosis and facilitates timely treatment to alleviate cerebral injury in the continuum of stroke care. However, there is still a lack of effective imaging methods to visualize the infarct area of ischemic stroke. In this study, we report a near-infrared II (NIR-II, 1-1.7 mu m) fluorophore HLX with the unique twisted donor-acceptor pi-architecture, which exhibits strong aggregation induced emission characteristics and high fluorescence quantum yield in the NIR-II window and near-infrared IIb (NIR-IIb, 1.5-1.7 mu m) region. The whole-body vascular imaging with superior clarity using HLX dots was ach-ieved. Most importantly, HLX dots was utilized to realize NIR-IIb fluorescence imaging of ischemic stroke in animals and dynamically monitor the therapeutic efficacy of salidroside for the first time. Our studies further demonstrate the neuroprotective effects of salidroside against cerebral ischemic injury through promoting angiogenesis. Superior biocompatibility enables HLX as a potential agent in the NIR-IIb region to light up the infarcted vessels and image-guided therapy of ischemic stroke.
C1 [Qiao, Xue; Wang, Wumei; Tian, Tian; Hong, Xuechuan] Tibet Univ, State Key Lab Virol, Coll Sci, Res Ctr Ecol,Lab Extreme Environm Biol Resources &, Lhasa 850000, Peoples R China.
   [Wang, Xiaobo; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.
   [Chen, Deliang] Gannan Normal Univ, Jiangxi Key Lab Organo Pharmaceut Chem, Chem & Chem Engn Coll, Ganzhou 341000, Peoples R China.
   [Xiao, Yuling; Luo, Haibin] Hainan Univ, Sch Pharmaceut Sci, Key Lab Trop Biol Resources, Minist Educ, Haikou 570228, Peoples R China.
   [Li, Yang; Zeng, Xiaodong] Wuhan Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China.
   [Xiao, Yuling] Bohai Rim Adv Res Inst Drug Discovery, Shandong Lab Yantai Drug Discovery, Yantai 264117, Peoples R China.
C3 Xizang University; Chengdu University of Traditional Chinese Medicine;
   Gannan Normal University; Hainan University; Wuhan University; Shandong
   Laboratory of Yantai Drug Discovery
RP Hong, XC (corresponding author), Tibet Univ, State Key Lab Virol, Coll Sci, Res Ctr Ecol,Lab Extreme Environm Biol Resources &, Lhasa 850000, Peoples R China.; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.; Chen, DL (corresponding author), Gannan Normal Univ, Jiangxi Key Lab Organo Pharmaceut Chem, Chem & Chem Engn Coll, Ganzhou 341000, Peoples R China.; Xiao, YL (corresponding author), Hainan Univ, Sch Pharmaceut Sci, Key Lab Trop Biol Resources, Minist Educ, Haikou 570228, Peoples R China.; Zeng, XD (corresponding author), Wuhan Univ, Shenzhen Inst, Shenzhen 518057, Peoples R China.
EM xiaoyl@whu.edu.cn; dechen@gnnu.cn; xlm999@cdutcm.edu.cn;
   zengxiaodong@sjtu.edu.cn; xhy78@whu.edu.cn
RI Deliang, Chen/AAB-2083-2021; Wang, Xiaobo/S-2476-2019; Zeng,
   Xiaodong/PVC-4500-2026
OI Zeng, Xiaodong/0000-0002-1442-0538; 
FU NSFC [82273796, 82111530209, 82274207]; Special Funds for Guiding Local
   Science and Technology Development of Central Government
   [XZ202202YD0021C, XZ202001YD0028C]; Shenzhen Science and Technology
   Research Grant [JCYJ20220530140605012]; Double Thousand Plan of Jiangxi
   Province [jxsq2020102130]; Hubei Province Scientific and Technical
   Innovation Key Project [2020BAB058]; Graduate High-level Talent Training
   Program of Tibet University [2020-GSP-B019]; Tibet Autonomous Region
   COVID-19 Prevention and Control Programs for Science and Technology
   Development
FX This work was partially supported by grants from NSFC (82273796,
   82111530209, 82274207), Special Funds for Guiding Local Science and
   Technology Development of Central Government (XZ202202YD0021C,
   XZ202001YD0028C), Tibet Autonomous Region COVID-19 Prevention and
   Control Programs for Science and Technology Development, Shenzhen
   Science and Technology Research Grant (JCYJ20220530140605012), the
   Double Thousand Plan of Jiangxi Province (jxsq2020102130), Hubei
   Province Scientific and Technical Innovation Key Project (2020BAB058),
   and Graduate High-level Talent Training Program of Tibet University
   (2020-GSP-B019).
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NR 64
TC 6
Z9 6
U1 5
U2 54
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0143-7208
EI 1873-3743
J9 DYES PIGMENTS
JI Dyes Pigment.
PD APR
PY 2023
VL 212
AR 111123
DI 10.1016/j.dyepig.2023.111123
EA FEB 2023
PG 9
WC Chemistry, Applied; Engineering, Chemical; Materials Science, Textiles
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering; Materials Science
GA C9MN1
UT WOS:000965077300001
DA 2026-05-27
ER

PT J
AU Zhao, MJ
   Wu, N
   Piao, Y
   Sun, CH
   Jin, JY
   Cui, CY
   Du, P
   Yin, XJ
   Jin, LL
   Zhang, CH
AF Zhao, Mingjing
   Wu, Nan
   Piao, Yan
   Sun, Chonghao
   Jin, Junyi
   Cui, Chengyu
   Du, Peng
   Yin, Xiongjie
   Jin, Lili
   Zhang, Changhao
TI Research and development of natural product Salidroside: Pharmacology,
   total synthesis and structural modifications
SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Review
DE Salidroside ( SAL ); Pharmacology; Total synthesis; Structural
   modification; Structure-activity relationship
ID PULMONARY ARTERIAL-HYPERTENSION; INDUCED MYOCARDIAL INJURY;
   HIPPOCAMPAL-NEURONS; GASTRIC-CANCER; IN-VITRO; APOPTOSIS; CELL;
   MECHANISM; SEPSIS; PROLIFERATION
AB Salidroside (SAL) is a glycoside compound with good biological activity, which has multi-target therapeutic potential for various disease. It can significantly regulate various receptors, inflammatory mediators and signaling pathways. However, due to the problems of low content of natural sources, difficulty in isolation and purification and poor bioavailability, SAL cannot be widely used in clinical treatment. This article reviews the chemical total synthesis methods and the typical pharmacological effects of SAL, mainly about anti-tumor, antihypoxia and anti-sepsis fields. In addition, this article focuses on summarizing the research progress on the structural modification of SAL. Summarized the structure-activity relationship of SAL and its derivatives. These contents can enhance scholars' understanding of the current research progress on SAL, overcome the limitations which SAL is faced, and provide constructive insights for further development of new drugs based on SAL.
C1 [Zhao, Mingjing; Wu, Nan; Piao, Yan; Sun, Chonghao; Jin, Junyi; Cui, Chengyu; Du, Peng; Yin, Xiongjie; Jin, Lili; Zhang, Changhao] Yanbian Univ, Coll Pharm, Key Lab Nat Med Changbai Mt, Minist Educ, Yanji 133002, Peoples R China.
C3 Yanbian University
RP Yin, XJ; Jin, LL; Zhang, CH (corresponding author), Yanbian Univ, Coll Pharm, Key Lab Nat Med Changbai Mt, Minist Educ, Yanji 133002, Peoples R China.
EM YinXJ@ybu.edu.cn; jinlili@ybu.edu.cn; zhangch@ybu.edu.cn
RI Lili, Jin/GQI-2718-2022
FU National Natural Science Foundation of China [82160741, 82160666];
   Education Department of Jilin Province [JJKH20240704KJ]
FX This work was supported by the National Natural Science Foundation of
   China (No. 82160741, 82160666) , Education Department of Jilin Province
   (No. JJKH20240704KJ) .
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NR 169
TC 2
Z9 2
U1 27
U2 36
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0223-5234
EI 1768-3254
J9 EUR J MED CHEM
JI Eur. J. Med. Chem.
PD DEC 15
PY 2025
VL 300
AR 118186
DI 10.1016/j.ejmech.2025.118186
EA SEP 2025
PG 26
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 7RU3C
UT WOS:001578129800003
PM 40986986
OA hybrid
DA 2026-05-27
ER

PT J
AU Luo, M
   Peng, HL
   Deng, ZH
   Yin, ZH
   Zhao, Q
   Xiong, H
AF Luo, Mei
   Peng, Hailong
   Deng, Zhonghua
   Yin, Zhonghua
   Zhao, Qiang
   Xiong, Hua
TI Preparation and Characterization of Genipin-Crosslinked Chitosan
   Microspheres for the Sustained Release of Salidroside
SO INTERNATIONAL JOURNAL OF FOOD ENGINEERING
LA English
DT Article
DE salidroside; chitoson microsphere; genipin crosslinking; sustained
   release
ID IN-VITRO; DELIVERY; LINKING; CARRIER; HYPOXIA; PROTEIN; ACID
AB Chitosan microspheres (CsMs) that encapsulate salidroside (Sal) were prepared by the emulsion crosslinking method with naturally occurring genipin (Gp) and then examined for their in vitro release. Sal-loaded CsMs (Sal-CsMs) showed nearly spherical and smooth surfaces with internal voids. The particle size of Sal-CsMs ranged within 0.56-5.01 mu m, and their encapsulation efficiency and loading capacity were beyond 77.58% and 23.29%, respectively. The stability of Sal improved after entrapment into the CsMs. The release rate of Sal from CsMs was initially rapid, followed by sustained release. The release behavior depended on the pH of the release medium. The main release mechanisms underlying the release procedure were anomalous behavior and Fickian diffusion. These results indicated that CsMs with a novel crosslinker of Gp was a potential carrier system for producing functional foods containing Sal.
C1 [Luo, Mei; Peng, Hailong; Deng, Zhonghua; Zhao, Qiang; Xiong, Hua] Nanchang Univ, State Key Lab Food Sci & Technol, Nanchang 330047, Jiangxi, Peoples R China.
   [Luo, Mei; Peng, Hailong; Yin, Zhonghua] Nanchang Univ, Dept Chem Engn, Nanchang 330031, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University
RP Xiong, H (corresponding author), Nanchang Univ, State Key Lab Food Sci & Technol, 235 Nanjing East Rd, Nanchang 330047, Jiangxi, Peoples R China.
EM luomei@ncu.edu.cn; peng_hailong@aliyun.com; hello_world_value@126.com;
   m15170002676@163.com; qiangzhao1221@yahoo.com; huaxiong100@126.com
OI Zhao, Qiang/0000-0002-9601-0304
FU Planning Subject of "the Twelfth Five-Year-Plan" National Science and
   Technology for the Rural development of China [2013AA102203-05];
   National Natural Science Foundation of China [21266020]; Natural Science
   Foundation of Jiangxi Province [20142BAB213003]; Jiangxi Department of
   Education Fund [GJJ13039]
FX This work was supported by the Planning Subject of "the Twelfth
   Five-Year-Plan" National Science and Technology for the Rural
   development of China (No. 2013AA102203-05), the National Natural Science
   Foundation of China (No. 21266020), the Natural Science Foundation of
   Jiangxi Province (20142BAB213003), and Jiangxi Department of Education
   Fund (GJJ13039).
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TC 26
Z9 26
U1 2
U2 120
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 2194-5764
EI 1556-3758
J9 INT J FOOD ENG
JI Int. J. Food Eng.
PD JUN
PY 2015
VL 11
IS 3
BP 323
EP 333
DI 10.1515/ijfe-2014-0314
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA CJ1CR
UT WOS:000355220100002
DA 2026-05-27
ER

PT J
AU Li, H
   Piao, XC
   Gao, R
   Jin, MY
   Jiang, J
   Lian, ML
AF Li, He
   Piao, Xuan Chun
   Gao, Ri
   Jin, MeiYu
   Jiang, Jun
   Lian, Mei Lan
TI Effect of several physicochemical factors on callus biomass and
   bioactive compound accumulation of R-sachalinensis bioreactor
   culture
SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT
LA English
DT Article
DE Balloon-type airlift bioreactor; Sparger size; Light intensity; Medium
   condition; Kinetics
ID ADVENTITIOUS ROOT CULTURES; LARGE-SCALE PRODUCTION; MEDIUM SALT
   STRENGTH; RHODIOLA-SACHALINENSIS; SUSPENSION-CULTURES; AIRLIFT
   BIOREACTOR; GROWTH; SALIDROSIDE; CELLS; ANTIOXIDANT
AB To optimize a bioreactor callus culture system for Rhodiola sachalinensis, several physicochemical factors affecting callus growth and bioactive compound accumulation were studied using a 3-L, balloon-type airlift bioreactor system. A bioreactor with a sparger size of 3.5-cm diameter was optimal for the callus culture of R. sachalinensis. Suitable light intensities for R. sachalinensis callus growth and biosynthesis of various kinds of bioactive compounds (salidroside, polysaccharides, phenolics, and flavonoids) were different. Maximum productivity of all bioactive compounds was found at a light intensity of 30 mu mol m(-2) s(-1). Callus growth and production of salidroside, polysaccharides, and flavonoids were stimulated with sucrose at a concentration of 30 g L-1, but 50 g L-1 was favorable for the production of phenolics. Salidroside accumulation was promoted when MS medium salt strength increased to 1.5 x MS, 1 x MS was best for the production of polysaccharides and flavonoids, and 0.5 x MS was proper for phenolic production. A kinetics study indicated that a culture duration of 20-25 d was appropriate for the mass production of bioactive compounds from R. sachalinensis callus in a bioreactor system. Callus culture in a bioreactor can be an alternative method for producing materials from R. sachalinensis for commercial drug production.
C1 [Li, He; Piao, Xuan Chun; Gao, Ri; Jin, MeiYu; Jiang, Jun; Lian, Mei Lan] Yanbian Univ, Key Lab Nat Resource Changbai Mt & Funct Mol, Minist Educ, Pk Rd 977, Yanji 133002, Jilin, Peoples R China.
C3 Yanbian University
RP Piao, XC; Lian, ML (corresponding author), Yanbian Univ, Key Lab Nat Resource Changbai Mt & Funct Mol, Minist Educ, Pk Rd 977, Yanji 133002, Jilin, Peoples R China.
EM nyypxc@ybu.edu.cn; lianmeilan2001@163.com
OI Jiang, Jun/0000-0001-5345-9016
FU National Natural Science Foundation of China [81160497]
FX Project 81160497 is supported by the National Natural Science Foundation
   of China.
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NR 39
TC 15
Z9 16
U1 0
U2 28
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1054-5476
EI 1475-2689
J9 IN VITRO CELL DEV-PL
JI In Vitro Cell. Dev. Biol.-Plant
PD JUN
PY 2016
VL 52
IS 3
BP 241
EP 250
DI 10.1007/s11627-016-9758-5
PG 10
WC Plant Sciences; Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Cell Biology; Developmental Biology
GA DQ5TD
UT WOS:000379267000004
DA 2026-05-27
ER

PT J
AU He, SN
   Xie, F
   Su, WY
   Luo, HB
   Chen, DL
   Cai, J
   Hong, XC
AF He, Shengnan
   Xie, Fang
   Su, Wuyue
   Luo, Haibin
   Chen, Deliang
   Cai, Jie
   Hong, Xuechuan
TI Anti-Inflammatory Salidroside Delivery from Chitin Hydrogels for NIR-II
   Image-Guided Therapy of Atopic Dermatitis
SO JOURNAL OF FUNCTIONAL BIOMATERIALS
LA English
DT Article
DE the quaternized beta-chitin; dextran hydrogel; imaging in the second
   near-infrared window (NIR-II); atopic dermatitis; Rhodiola rosea;
   treatment
ID RHODIOLA-ROSEA; INJECTABLE HYDROGELS; CHITOSAN; FLUOROPHORES
AB Atopic dermatitis (AD) is the most common heterogeneous skin disease. Currently, effective primary prevention approaches that hamper the occurrence of mild to moderate AD have not been reported. In this work, the quaternized b-chitin dextran (QCOD) hydrogel was adopted as a topical carrier system for topical and transdermal delivery of salidroside for the first time. The cumulative release value of salidroside reached similar to 82% after 72 h at pH 7.4, while in vitro drug release experiments proved that QCOD@Sal (QCOD@Salidroside) has a good, sustained release effect, and the effect of QCOD@Sal on atopic dermatitis mice was further investigated. QCOD@Sal could promote skin repair or AD by modulating inflammatory factors TNF-a and IL-6 without skin irritation. The present study also evaluated NIR-II image-guided therapy (NIR-II, 1000-1700 nm) of AD using QCOD@Sal. The treatment process of AD was monitored in real-time, and the extent of skin lesions and immune factors were correlated with the NIR-II fluorescence signals. These attractive results provide a new perspective for designing NIR-II probes for NIR-II imaging and image-guided therapy with QCOD@Sal.
C1 [He, Shengnan; Su, Wuyue; Hong, Xuechuan] Tibet Univ, Coll Sci, Med Coll,Lab Extreme Environm Biol Resources & Ada, Res Ctr Ecol,State Key Lab Virol, Lhasa 850000, Peoples R China.
   [Xie, Fang; Cai, Jie] Wuhan Univ, Coll Chem & Mol Sci, Hubei Engn Ctr Nat Polymers Based Med Mat, Wuhan 430072, Peoples R China.
   [Luo, Haibin] Hainan Univ, Sch Pharmaceut Sci, Key Lab Trop Biol Resources Minist Educ, Haikou 570228, Peoples R China.
   [Chen, Deliang] Gannan Normal Univ, Chem & Chem Engn Coll, Jiangxi Key Lab Organo Pharmaceut Chem, Ganzhou 341000, Peoples R China.
   [Cai, Jie] Wuhan Univ, Zhongnan Hosp, Inst Hepatobiliary Dis, Wuhan 430071, Peoples R China.
   [Hong, Xuechuan] Wuhan Univ, Shenzhen Res Inst, Shenzhen 518057, Peoples R China.
C3 Xizang University; Wuhan University; Hainan University; Gannan Normal
   University; Wuhan University; Wuhan University
RP Hong, XC (corresponding author), Tibet Univ, Coll Sci, Med Coll,Lab Extreme Environm Biol Resources & Ada, Res Ctr Ecol,State Key Lab Virol, Lhasa 850000, Peoples R China.; Cai, J (corresponding author), Wuhan Univ, Coll Chem & Mol Sci, Hubei Engn Ctr Nat Polymers Based Med Mat, Wuhan 430072, Peoples R China.; Cai, J (corresponding author), Wuhan Univ, Zhongnan Hosp, Inst Hepatobiliary Dis, Wuhan 430071, Peoples R China.; Hong, XC (corresponding author), Wuhan Univ, Shenzhen Res Inst, Shenzhen 518057, Peoples R China.
EM caijie@whu.edu.cn; xhy78@whu.edu.cn
RI Cai, Jie/E-5689-2016; Deliang, Chen/AAB-2083-2021
OI Cai, Jie/0000-0002-0660-4740; Su, Wuyue/0000-0002-4347-1502; 
FU NSFC [82273796, 82111530209, 52173105]; Special Funds for Guiding Local
   Science and Technology Development of Central Government
   [XZ202202YD0021C, XZ202001YD0028C]; Tibet Autonomous Region COVID-19
   Prevention and Control Programs for Science and Technology Development
   [XZ202201ZY0046G]; Shenzhen Science and Technology Research Grant
   [JCYJ20220530140605012]; Guangdong Basic and Applied Basic Research
   Foundation [2023A1515012649]; Double Thousand Plan of Jiangxi Province
   [jxsq2020102130]; Hubei Province Scientific and Technical Innovation Key
   Project [2020BAB058, 2020BCA079]; Fundamental Research Funds for the
   Central University
FX This work was partially supported by grants from NSFC (82273796,
   82111530209, 52173105), Special Funds for Guiding Local Science and
   Technology Development of Central Government (XZ202202YD0021C,
   XZ202001YD0028C), Tibet Autonomous Region COVID-19 Prevention and
   Control Programs for Science and Technology Development
   (XZ202201ZY0046G), Shenzhen Science and Technology Research Grant
   (JCYJ20220530140605012), Guangdong Basic and Applied Basic Research
   Foundation (2023A1515012649), the Double Thousand Plan of Jiangxi
   Province (jxsq2020102130), Hubei Province Scientific and Technical
   Innovation Key Project (2020BAB058, 2020BCA079), and the Fundamental
   Research Funds for the Central University.
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NR 60
TC 11
Z9 12
U1 5
U2 100
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2079-4983
J9 J FUNCT BIOMATER
JI J. Func. Biomater.
PD MAR
PY 2023
VL 14
IS 3
AR 150
DI 10.3390/jfb14030150
PG 15
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA C2CI7
UT WOS:000960055800001
PM 36976074
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yang, XM
   Xu, W
   Zhao, WJ
   Zhao, YH
   Yang, YM
   Ling, Y
AF Yang, Xiaoming
   Xu, Wen
   Zhao, Weijia
   Zhao, Yahong
   Yang, Yumin
   Ling, Yong
TI Synthesis and Neuroprotective Effects of the Fluorine Substituted
   Salidroside Analogues in the PC12 Cell Model Exposed to Hypoglycemia and
   Serum Limitation
SO CHEMICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE salidroside (Sal) analogue; hypoglycemia serum limitation;
   neuroprotective effect; apoptosis
ID APOPTOSIS
AB Salidroside (Sal) is a natural antioxidant extracted from the root of Rhodiola rosea L., a traditional Chinese medicinal plant, which elicits neuroprotective effects in the treatment of ischemic stroke. In an attempt to improve its neuroprotective effects, fluorine substituted Sal analogues were synthesized and their neuroprotective activities against the hypoglycemia and serum limitation induced cell injury in differentiated PC12 cells were evaluated. The target compounds displayed strong protective effects on the cell viability against the damage caused by hypoglycemia and serum limitation, especially for D1, which had a great potency superior to Sal and efficiently inhibited hypoglycemia and serum limitation induced cell nuclear morphologic changes and the increased apoptotic rate in a dose-dependent manner. These new findings may provide potentially important information for further development of Sal analogues and lay the basis for further studies on the cerebral ischemic stroke and neurodegenerative diseases for human clinical treatment.
C1 [Yang, Xiaoming; Xu, Wen; Zhao, Yahong; Yang, Yumin] Nantong Univ, JiangSu Key Lab Neuroregenerat, Nantong 226001, Peoples R China.
   [Ling, Yong] Nantong Univ, Sch Med, Dept Pharm, Nantong 226001, Peoples R China.
   [Zhao, Weijia] Nantong Univ, Sch Life Sci, Nantong 226019, Peoples R China.
C3 Nantong University; Nantong University; Nantong University
RP Yang, YM (corresponding author), Nantong Univ, JiangSu Key Lab Neuroregenerat, Nantong 226001, Peoples R China.
EM yangym@ntu.edu.cn; Lyyy111@sina.com
RI Zhao, Yahong/JFA-2536-2023
FU Natural Science Foundation of China [21242005, 81171457]; Biotechnology
   and New Medicine Projects of Nantong City [AS2011016]; Nature Science
   Foundation of Nantong University [10Z074, 12ZY035]; Priority Academic
   Programs Development of Jiangsu Higher Education Institutions (PAPD)
FX We gratefully acknowledge the financial support by the Natural Science
   Foundation of China (Grant Nos. 21242005 and 81171457), Biotechnology
   and New Medicine Projects of Nantong City (AS2011016), Nature Science
   Foundation of Nantong University (Grant Nos. 10Z074 and 12ZY035), and
   also thank a project funded by the Priority Academic Programs
   Development of Jiangsu Higher Education Institutions (PAPD).
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NR 20
TC 4
Z9 5
U1 0
U2 26
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0009-2363
J9 CHEM PHARM BULL
JI Chem. Pharm. Bull.
PD NOV
PY 2013
VL 61
IS 11
BP 1192
EP 1196
PG 5
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA 244AP
UT WOS:000326359800015
PM 24189306
DA 2026-05-27
ER

PT J
AU Potocká, EK
   Mastihubová, M
   Mastihuba, V
AF Potocka, Elena Karnisova
   Mastihubova, Maria
   Mastihuba, Vladimir
TI Transrutinosylation of tyrosol by flower buds of Sophora japonica
SO FOOD CHEMISTRY
LA English
DT Article
DE Rutinosidase; Rutin; Sophora japonica; Tyrosol rutinoside;
   Transglycosylation
ID ENZYMATIC-SYNTHESIS; SALIDROSIDE; HYDROXYTYROSOL; RUTINOSIDES;
   GLYCOSIDASE; RUTIN
AB Dried flower buds of Japanese sophora (Sophora japonica) comprising rutinosidase activity were tested in rutinosylation of tyrosol via transglycosylation process from rutin. Optimal conditions for transrutinosylation of tyrosol were 49 mM rutin and 290 mM tyrosol, giving maximum conversion up to 66.4% and 24% yield of isolated and purified rutinoside. The rutinosylation proceeded exclusively on the primary hydroxyl of tyrosol, thus forming rhamnosylated derivative of salidroside. This strict regioselectivity differentiates the sophora biocatalyst from microbial rutinosidases.
C1 [Potocka, Elena Karnisova; Mastihubova, Maria; Mastihuba, Vladimir] Slovak Acad Sci, Inst Chem, Dubravska Cesta 9, SK-84538 Bratislava, Slovakia.
C3 Slovak Academy of Sciences; Institute of Chemistry, SAS
RP Mastihuba, V (corresponding author), Slovak Acad Sci, Inst Chem, Dubravska Cesta 9, SK-84538 Bratislava, Slovakia.
EM vladimir.mastihuba@savba.sk
RI Karnišová Potocká, Elena/AAU-9718-2021; Mastihubova,
   Maria/OZG-0746-2025; Mastihuba, Vladimír/S-7938-2017
OI Karnišová Potocká, Elena/0000-0003-1546-4134; Mastihubova,
   Maria/0000-0003-3033-811X; Mastihuba, Vladimír/0000-0003-2587-2553
FU Slovak Research and Development Agency [APVV-18-0188]; Slovak Grant
   Agency for Science VEGA [2/0126/19]
FX This work was supported by the Slovak Research and Development Agency
   under the contract No. APVV-18-0188. The work was also supported by the
   Slovak Grant Agency for Science VEGA (grant number 2/0126/19).
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U1 3
U2 75
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD JAN 30
PY 2021
VL 336
AR 127674
DI 10.1016/j.foodchem.2020.127674
PG 5
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA NX4ZI
UT WOS:000575720700014
PM 32781353
DA 2026-05-27
ER

PT J
AU Wen, KC
   Chang, CS
   Chien, YC
   Wang, HW
   Wu, WC
   Wu, CS
   Chiang, HM
AF Wen, Kuo-Ching
   Chang, Chih-Shiang
   Chien, Yin-Chih
   Wang, Hsiao-Wen
   Wu, Wan-Chen
   Wu, Chin-Sheng
   Chiang, Hsiu-Mei
TI Tyrosol and Its Analogues Inhibit Alpha-Melanocyte-Stimulating Hormone
   Induced Melanogenesis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE melanogenesis; melanocortin 1 receptor; tyrosol; tyrosol analogues;
   tyrosinase-related protein
ID TYROSINASE INHIBITORS; MELANIN BIOSYNTHESIS; OXIDASE ACTIVITY; ACID;
   EXPRESSION; MELANOCORTIN; MECHANISM; MESSENGER; PATHWAY; MELASMA
AB Melanin is responsible for skin color and plays a major role in defending against harmful external factors such as ultraviolet (UV) irradiation. Tyrosinase is responsible for the critical steps of melanogenesis, including the rate-limiting step of tyrosine hydroxylation. The mechanisms of action of skin hypopigmenting agents are thought to be based on the ability of a given agent to inhibit the activity of tyrosinase and, hence, down regulate melanin synthesis. Tyrosol and its glycoside, salidroside, are active components of Rhodiola rosea, and in our preliminary study we found that Rhodiola rosea extract inhibited melanogenesis. In this study, we examined the effects of tyrosol and its analogues on melanin synthesis. We found that treatment of B16F0 cells to tyrosol (1), 4-hydroxyphenylacetic acid (5), 3-hydroxyphenylacetic acid (6), 2-hydroxyphenylacetic acid (7), or salidroside (11) resulted in a reduction in melanin content and inhibition of tyrosinase activity as well as its expression. Tyrosol (1), 4-hydroxyphenylacetic acid (5) and 2-hydroxyphenylacetic acid (7) suppressed MC1R expression. Tyrosol (1), 4-hydroxyphenylacetic acid (5), 3-hydroxyphenylacetic acid (6), and 2-hydroxyphenylacetic acid (7) inhibited -MSH induced TRP-1 expression, but salidroside (11) did not. All the compounds did not affect MITF and TRP-2 expression. Furthermore, we found that the cell viability of tyrosol (1), 4-hydroxyphenylacetic acid (5), 3-hydroxyphenylacetic acid (6), and 2-hydroxyphenylacetic acid (7) at concentrations below 4 mM and salidroside (11) at concentrations below 0.5 mM were higher than 90%. The compounds exhibited metal-coordinating interactions with copper ion in molecular docking with tyrosinase. Our results suggest that tyrosol, 4-hydroxyphenylacetic acid, 3-hydroxyphenylacetic acid, 2-hydroxyphenylacetic acid, and salidroside are potential hypopigmenting agents.
C1 [Wen, Kuo-Ching; Chien, Yin-Chih; Wang, Hsiao-Wen; Wu, Wan-Chen; Wu, Chin-Sheng; Chiang, Hsiu-Mei] China Med Univ, Dept Cosmeceut, Taichung 404, Taiwan.
   [Chang, Chih-Shiang] China Med Univ, Grad Inst Pharmaceut Chem, Taichung 404, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan
RP Chiang, HM (corresponding author), China Med Univ, Dept Cosmeceut, Taichung 404, Taiwan.
EM kcwen0520@mail.cmu.edu.tw; chihshiang@mail.cmu.edu.tw;
   stacy592@gmail.com; hsesalice@hotmail.com; wanjn1024@hotmail.com;
   cswu@mail.cmu.edu.tw; hmchiang@mail.cmu.edu.tw
RI CHIANG, HSIU-MEI/L-8150-2013
OI CHIANG, HSIU-MEI/0000-0002-1586-910X
FU National Science Council, Taipei, Taiwan [NSC100-2320-B-039-002-MY3,
   NSC99-2622-B-039-001-CC3]
FX This study was sponsored by the National Science Council
   (NSC100-2320-B-039-002-MY3; NSC99-2622-B-039-001-CC3), Taipei, Taiwan.
   The authors appreciate Ko Da Pharmaceutical Co. Ltd. for supplying
   salidroside.
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NR 43
TC 51
Z9 53
U1 1
U2 81
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD DEC
PY 2013
VL 14
IS 12
BP 23420
EP 23440
DI 10.3390/ijms141223420
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 296XX
UT WOS:000330219800016
PM 24287915
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yang, G
   An, D
   Lee, MH
   Lee, K
   Kim, B
   Suman, CK
   Ham, I
   Choi, HY
AF Yang, Gabsik
   An, Duckgun
   Lee, Mi-Hwa
   Lee, Kyungjin
   Kim, Bumjung
   Suman, Chinannai Khanita
   Ham, Inhye
   Choi, Ho-Young
TI Effect of Acer tegmentosum bark on atopic dermatitis-like skin
   lesions in NC/Nga mice
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Atopic dermatitis; Acer tegmentosum; Dermatophagoides farina;
   Salidroside; Thymic stromal lymphopoietin
ID THYMIC STROMAL LYMPHOPOIETIN; IN-VITRO; SYNTHETIC SALIDROSIDE; DENDRITIC
   CELLS; EXTRACT; DISEASE; INFLAMMATION; MECHANISMS; GROWTH
AB Ethnopharmacological relevance: Atopic dermatitis (AD) is a chronic and relapsing inflammatory condition characterized by pruritic and eczematous skin lesions that requires safe and effective pharmacological therapy. The bark of Acer tegmentosum Maxim trees has been used in Korean folk and traditional medicine to treat abscesses, surgical bleeding, liver diseases, and AD.
   Aim of study: To investigate the therapeutic effect of A. tegmentosum, on a mouse model of Dermatophagoides farinae (Df)-induced AD.
   Methods: Development of AD-like skin lesions was induced by repetitive skin contact with barrier-disrupted backs of NC/Nga mice with Df body ointment, and the effects of A. tegmentosum were evaluated on the basis of histopathological skin assessment results, ear swelling, and cytokine production in the dorsal skin. The component of A. tegmentosum, salidroside, inhibited the production of TSLP in KCMH-1 cells, which indicated that its production could be pharmacologically regulated.
   Results: Topical application of A. tegmentosum for 1 week after Df body ointment challenge significantly reduced ear swelling and improved dorsal skin lesions. Suppression of dermatitis by combined therapy was accompanied by a decrease in the skin level of Th2 cytokines, such as interleukin (IL)-4, IL-5 and IL13, plasma levels of thymus and activation-regulated chemokine, and IgE. Induction of thymic stromal lymphopoietin, which leads to a systemic Th2 response, was also reduced in in vivo and in vitro by A. tegmentosum and salidroside.
   Conclusions: Our findings suggest that A. tegmentosum treatment has a significant therapeutic effect on Df-induced AD-like skin lesions on NC/Nga mice through inhibition of thymic stromal lymphopoietin and IgE via a mechanism that may inhibit Th2-mediated immune responses. These results suggest that A. tegmentosum and salidroside may be useful tools for the treatment of AD. (c) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Yang, Gabsik; An, Duckgun; Lee, Mi-Hwa; Lee, Kyungjin; Kim, Bumjung; Suman, Chinannai Khanita; Ham, Inhye; Choi, Ho-Young] Kyung Hee Univ, Coll Korean Med, Dept Herbol, Seoul, South Korea.
   [Yang, Gabsik] Catholic Univ Korea, Coll Pharm, Integrated Res Inst Pharmaceut Sci, Bucheon 420743, South Korea.
C3 Kyung Hee University; Catholic University of Korea
RP Choi, HY (corresponding author), Kyung Hee Univ, Coll Korean Med, Dept Herbol, Seoul, South Korea.
EM hychoi@khu.ac.kr
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NR 46
TC 17
Z9 19
U1 0
U2 10
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JAN 11
PY 2016
VL 177
BP 53
EP 60
DI 10.1016/j.jep.2015.10.033
PG 8
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA DB0RJ
UT WOS:000368214900007
PM 26619913
DA 2026-05-27
ER

PT J
AU Zhang, MM
   Hu, ZY
   Fang, BQ
   Bao, XJ
   Xiang, Z
   Wang, HX
AF Zhang, Manman
   Hu, Zhiyan
   Fang, Bingqing
   Bao, Xiujie
   Xiang, Zheng
   Wang, Haixing
TI Pharmacokinetic study of rosavin in rat plasma with ultra performance
   LC-MS/MS after intravenous and gavage administration
SO BIOANALYSIS
LA English
DT Article
DE multiple reaction monitoring; pharmacokinetics; rat plasma; rosavin;
   ultra performance LC-MS/MS
ID RHODIOLA-ROSEA L.; LIQUID-CHROMATOGRAPHY; IN-VITRO; SALIDROSIDE;
   EXTRACTS; QUANTIFICATION; CONSTITUENTS
AB Aim: A sensitive and selective ultra performance LC-MS/MS (UPLC-MS/MS) method was developed to investigate the pharmacokinetics of rosavin as a potential adaptogenic drug isolated from Rhodiola rosa L. in rat plasma with salidroside as an internal standard. Methodology: Chromatographic separation was performed on a UPLC HSS T3 column (1.8 mu m, 100 mm x 2.1 mm) with gradient elution. Multiple reaction monitoring was employed for MS analysis. Rosavin and salidroside were determined with multiple reaction monitoring-ion transitions m/z 427.2 -> 293.1 and m/z 299.1 -> 119.1, respectively. Conclusion: The validated UPLC-MS/MS method showed a satisfied linear range in 5-5000 ng/ml-1 and was successfully applied for the pharmacokinetic study of rosavin in the rat after intravenous and gavage administration.
C1 [Zhang, Manman] Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou, Peoples R China.
   [Hu, Zhiyan; Fang, Bingqing; Bao, Xiujie; Wang, Haixing] Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Zhejiang Prov Key Lab Anesthesiol, Wenzhou, Peoples R China.
   [Hu, Zhiyan; Fang, Bingqing; Bao, Xiujie; Wang, Haixing] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.
   [Xiang, Zheng] Wenzhou Med Univ, Sch Pharmaceut Sci, Dept Pharmaceut Anal, Wenzhou, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University; Wenzhou Medical University
RP Wang, HX (corresponding author), Wenzhou Med Univ, Affiliated Hosp 2, Dept Anesthesiol, Zhejiang Prov Key Lab Anesthesiol, Wenzhou, Peoples R China.; Wang, HX (corresponding author), Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.
EM wanghaixing@wmu.edu.cn
FU Zhejiang Provincial Public Welfare Technology Research Project
   [LGF19H180013, LGC19H280007]; Wenzhou City Public Welfare Science and
   Technology Plan Project [Y20170149]
FX This work was funded by the Zhejiang Provincial Public Welfare
   Technology Research Project (LGF19H180013 and LGC19H280007) and the
   Wenzhou City Public Welfare Science and Technology Plan Project
   (Y20170149). The authors have no other relevant affiliations or
   financial involvement with any organization or entity with a financial
   interest in or financial conflict with the subject matter or materials
   discussed in the manuscript apart from those disclosed.
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NR 21
TC 7
Z9 7
U1 0
U2 24
PU FUTURE SCI LTD
PI LONDON
PA UNITED HOUSE, 2 ALBERT PL, LONDON, N3 1QB, ENGLAND
SN 1757-6180
EI 1757-6199
J9 BIOANALYSIS
JI Bioanalysis
PD MAY
PY 2019
VL 11
IS 9
BP 837
EP 845
DI 10.4155/bio-2019-0022
PG 9
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA IC3GW
UT WOS:000470848600003
PM 31094215
DA 2026-05-27
ER

PT J
AU Rattan, S
   Kumar, D
   Warghat, AR
AF Rattan, Shiv
   Kumar, Dinesh
   Warghat, Ashish R.
TI Growth kinetics, metabolite yield, and expression analysis of
   biosynthetic pathway genes in friable callus cell lines of Rhodiola
   imbricata (Edgew)
SO PLANT CELL TISSUE AND ORGAN CULTURE
LA English
DT Article
DE Antioxidant potential; Callus cell line; Growth kinetics; Salidroside
   yield; RT-qPCR; Rhodiola imbricata
ID LEAF EXPLANTS; FATTY-ACIDS; SALIDROSIDE; ACCUMULATION; CULTURE; TYROSOL;
   L.
AB The plant cell culture provides an efficient technique for growth and production kinetics studies of bioactive compounds present in plants. Therefore, the present study investigated, for the first time, to identify the specific culture days required for higher metabolite yield in Rhodiola imbricata. A transcript-level gene expression study was conducted to understand the molecular cues associated with metabolite biosynthesis. The leaf callus cell line showed an optimum growth rate (FW: 20 g/100 mL, DW: 1.21 g/100 mL), growth index (19.00), salidroside (3.68 mg/g DW, rosavin (0.21 mg/g DW and rosarin (0.08 mg/g DW) on 24th day of the incubation period. However, salidroside, rosavin, and rosarin metabolite yield followed the growth-dependent manner in both callus cell lines, while tyrosol and p-coumaric acid showed growth independent accumulation pattern. Moreover, the antioxidant study displayed maximum phenolic content (8.07 mg/g DW) on day 18, flavonoid content (9.73 mg/g DW) on day 3, and DPPH activity (IC50; 0.79 mg/mL) on day 24 in leaf callus cell line. The RT-qPCR analysis showed upregulation of PAL, 4-HPAAS, 4-HPAAR, and UDPGT genes associated with metabolite accumulation. Expression analysis revealed a positive correlation with the metabolites yield. Furthermore, the optimized parameter could be exploited for a higher yield of specific metabolite and sequential scale-up studies.
   Key message This is the first-ever study on the specific growth phase and accumulation pattern of metabolites in the friable callus cell lines of Rhodiola imbricata. Similarly, molecular signatures were also investigated to elucidate key genes associated with salidroside and rosavins biosynthesis. Furthermore, current optimized parameters lay the foundation for a cell suspension study, scale-up, and year-round metabolite production.
C1 [Rattan, Shiv; Warghat, Ashish R.] CSIR Inst Himalayan Bioresource Technol, Biotechnol Div, Palampur 176061, Himachal Prades, India.
   [Rattan, Shiv; Kumar, Dinesh; Warghat, Ashish R.] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India.
   [Kumar, Dinesh] CSIR Inst Himalayan Bioresource Technol, Chem Technol Div, Palampur 176061, Himachal Prades, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Himalayan Bioresource Technology (IHBT); Academy of
   Scientific & Innovative Research (AcSIR); Council of Scientific &
   Industrial Research (CSIR) - India; CSIR - Institute of Himalayan
   Bioresource Technology (IHBT)
RP Warghat, AR (corresponding author), CSIR Inst Himalayan Bioresource Technol, Biotechnol Div, Palampur 176061, Himachal Prades, India.; Warghat, AR (corresponding author), Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India.
EM shivrattan.negi@gmail.com; dineshkumar@ihbt.res.in;
   ashishwarghat@ihbt.res.in
RI Warghat, Ashish/AAS-6726-2020; Kumar, Dinesh/F-5081-2015
OI Warghat, Ashish/0000-0001-5867-3329; negi,
   Shivrattan/0000-0002-3896-0811; Kumar, Dinesh/0000-0003-4123-0235
FU Council of Scientific and Industrial Research (CSIR), Government of
   India [MLP-0201]; UGC, New Delhi
FX The authors acknowledge the Council of Scientific and Industrial
   Research (CSIR), Government of India, under the project
   "Biotechnological interventions for sustainable bio-economy generation
   through characterization, conservation, prospection and utilization of
   Himalayan bioresources (MLP-0201)" for providing financial support. SR
   acknowledges UGC, New Delhi for providing research fellowship and
   Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, India
   for Ph. D. enrolment. The authors are thankful to Director, CSIR-IHBT,
   Dr. Sanjay Kumar, for providing the necessary facilities. CSIR-IHBT
   publication number for this manuscript is 4768.
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NR 42
TC 10
Z9 11
U1 2
U2 15
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0167-6857
EI 1573-5044
J9 PLANT CELL TISS ORG
JI Plant Cell Tissue Organ Cult.
PD JUL
PY 2021
VL 146
IS 1
BP 149
EP 160
DI 10.1007/s11240-021-02057-8
EA MAR 2021
PG 12
WC Biotechnology & Applied Microbiology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Plant Sciences
GA SU8BQ
UT WOS:000632752700001
DA 2026-05-27
ER

PT J
AU Zhang, Q
   Wang, YQ
   Li, L
   Song, HL
   Wu, HT
   Zhu, BW
AF Zhang, Qian
   Wang, Yu-Qiao
   Li, Lin
   Song, Hao-Lin
   Wu, Hai-Tao
   Zhu, Bei-Wei
TI Fabrication and characterization of salidroside W/O/W emulsion with
   sodium alginate
SO FOOD CHEMISTRY-X
LA English
DT Article
DE Salidroside; W/O/W emulsion; Sodium alginate; Storage stability
ID MULTIPLE EMULSIONS; DELIVERY; STABILITY; RELEASE; NANOPARTICLES;
   FORMULATION; CHITOSAN; SYSTEMS; SHELL
AB Salidroside (Sal), the main bioactive substance in Rhodiola rosea, is a promising functional food component with a wide range of pharmacological effects, but its biological activity is challenging to sustain due to its short halflife, low oral bioavailability, and susceptibility to environmental factors. The aim of this study was to investigate the effect of sodium alginate (SA) concentration on the construction of W/O/W emulsion in the protection of Sal. With the escalation of SA concentrations, the range of droplet size distribution was smaller and the droplets were more uniform. When the concentration of SA was 2 %, the average droplet size reached 9.1 +/- 0.1 jm, and the encapsulation efficiency of Sal was 77.8 +/- 1.8 %. Moreover, the double emulsion with 2 % SA was the most stable for 28 days at 4 degree celsius since the oil droplets were embedded in the network structure of SA.
C1 [Zhang, Qian; Zhu, Bei-Wei] Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Jilin, Peoples R China.
   [Wang, Yu-Qiao; Li, Lin; Song, Hao-Lin; Wu, Hai-Tao; Zhu, Bei-Wei] Dalian Polytech Univ, SKL Marine Food Proc & Safety Control, Collaborat Innovat Ctr Seafood Deep Proc, Sch Food Sci & Technol,Natl Engn Res Ctr Seafood, Dalian 116034, Peoples R China.
C3 Jilin University; Dalian Polytechnic University
RP Zhu, BW (corresponding author), Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Jilin, Peoples R China.; Wu, HT; Zhu, BW (corresponding author), Dalian Polytech Univ, SKL Marine Food Proc & Safety Control, Collaborat Innovat Ctr Seafood Deep Proc, Sch Food Sci & Technol,Natl Engn Res Ctr Seafood, Dalian 116034, Peoples R China.
EM wht205@163.com; zhubeiwei@163.com
FU Science and Technology Program of Liaoning Province [2022JH1/10900010]
FX This work was supported by the Science and Technology Program of
   Liaoning Province (2022JH1/10900010) .
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NR 48
TC 28
Z9 30
U1 9
U2 74
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2590-1575
J9 FOOD CHEM X
JI Food Chem. X
PD JUN 30
PY 2024
VL 22
AR 101260
DI 10.1016/j.fochx.2024.101260
EA MAR 2024
PG 9
WC Chemistry, Applied; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology
GA OB1M6
UT WOS:001204709200001
PM 38450386
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Khokhlova, K
   Zdoryk, O
AF Khokhlova, Kateryna
   Zdoryk, Oleksandr
TI Authentication ofRhodiola rosea,Rhodiola
   quadrifidaandRhodiola rosealiquid extract from the Ukrainian
   market using HPTLC chromatographic profiles
SO NATURAL PRODUCT RESEARCH
LA English
DT Article
DE Rhodiola rosea; Rhodiola quadrifida; golden root; rosavins; salidroside;
   authentication; high-performance thin-layer chromatography
ID RHODIOLA-ROSEA; PLANTS
AB Rhodiola roseaandRhodiola quadrifidaare widely distributed and sold in Eastern Europe. The purpose of this paper was to identifyR.rosea,R.quadrifidaandRhodiola rosealiquid extract (RRLE) in the Ukrainian market and bring out adulteration cases using chromatographic characterisation by HPTLC. The multiple samples ofR.rosea,R.quadrifidaand RRLE were compared; the optimal chromatographic conditions for identification ofR.roseaand RRLE based on the presence of rosavins and salidroside as well as for identification ofR.quadrifidabased on the presence of salidroside were proposed; the specific HPTLC fingerprints were obtained; the acceptance criteria for each product were set. The adulteration cases forR.roseaand RRLE samples were established. The dependence on handlingR.roseaand presence of rosavins was determined. It was assumed that low-quality raw materials or inefficient technology process were used for RRLE. The consistency of HPTLC fingerprints forR.quadrifidasamples was established.
C1 [Khokhlova, Kateryna] Natl Univ Pharm, Dept Technol Drugs, Kharkiv, Ukraine.
   [Zdoryk, Oleksandr] Natl Univ Pharm, Dept Qual Standardizat & Certificat Drugs, Kharkiv, Ukraine.
C3 National University of Pharmacy; National University of Pharmacy
RP Khokhlova, K (corresponding author), Natl Univ Pharm, Dept Technol Drugs, Kharkiv, Ukraine.
EM kateryna_khokhlova@ukr.net
RI Zdoryk, Oleksandr/C-4502-2016; Khokhlova, Kateryna/K-7581-2018
OI Zdoryk, Oleksandr/0000-0002-2721-0281; Khokhlova,
   Kateryna/0000-0002-7151-6763
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NR 19
TC 9
Z9 13
U1 0
U2 32
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1478-6419
EI 1478-6427
J9 NAT PROD RES
JI Nat. Prod. Res.
PD OCT 1
PY 2020
VL 34
IS 19
BP 2842
EP 2846
DI 10.1080/14786419.2019.1591398
PG 5
WC Chemistry, Applied; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA NU9HC
UT WOS:000573945900020
PM 30919667
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Wang, ZY
   Qiang, X
   Peng, YJ
   Fu, WJ
   Zhao, QY
   He, D
AF Wang, Zongyuan
   Qiang, Xin
   Peng, Yijie
   Fu, Wenjie
   Zhao, Quanyi
   He, Dian
TI Design and synthesis of salidroside analogs and their bioactivity
   against septic myocardial injury
SO BIOORGANIC CHEMISTRY
LA English
DT Article
DE Salidroside; Sepsis; Anti-inflammatory; Anti -oxidative stress;
   Myocardial damage
ID AUTOPHAGIC CELL-DEATH; ACTIVATION; APOPTOSIS; PATHWAY; CANCER; ALPHA
AB Cardiac tissue suffers much from sepsis, and the incidence of myocardial injury is high in septic patients. The treatment of sepsis myocardial injury (SMI) has been the focus of clinical medicine. Salidroside shows myocardial cell protection, anti-oxidation and anti- inflammation effects, and it is thought as one of the potential compounds to treat sepsis myocardial injury. However, its anti-inflammatory activity is lower and its pharmacokinetic properties are not ideal, which is far from clinical application. Here, a series of salidroside analogs were synthesized, and their bioactivities were evaluated from several aspects, including their anti-oxidant and antiinflammatory activities in vitro and anti-sepsis myocardial injury activities in vivo. Of all the compounds which synthesized, compounds 2 and 3 exhibited stronger anti-inflammatory activities than the others; after treating LPS-stimulated RAW264.7 or H9c2 cells with each of them, the levels of IL-113, IL-6 and TNF-alpha were down-regulated in a dose-dependent manner. In the anti-oxidative stress injury test, compounds 2 and 3 not only markedly increased the survival rate of cells, and but also improved the cellular oxidative stress-related indicators MDA, SOD and cell damage marker LDH in a dose-dependent manner. In the LPS-induced septic rat myocardial injury models (in vivo), the two compounds also showed good bioactivities. They also reduced the expression of IL-113, IL-6 and TNF-alpha, and blocked cell damage by suppressing overhauled oxidation in septic rats. In addition, the myocardial injury was significantly improved and the inflammatory infiltration was reduced after treatment with the two compounds. In conclusion, the salidroside analogs (2 and 3) showed promising therapeutical effect on septic myocardial injury in LPS-model rats, and they could be good candidates for clinical trials against inflammation and septic myocardial injury.
C1 [Wang, Zongyuan; Qiang, Xin; Peng, Yijie; Fu, Wenjie; Zhao, Quanyi; He, Dian] Lanzhou Univ, Inst Med Chem, Mat Med Dev Grp, Sch Pharm, Lanzhou 730000, Peoples R China.
C3 Lanzhou University
RP Zhao, QY (corresponding author), Lanzhou Univ, Inst Med Chem, Mat Med Dev Grp, Sch Pharm, Lanzhou 730000, Peoples R China.
EM zhaoqy@lzu.edu.cn
FU Natural Science Foundation of Gansu Province of China [22JR5RA507]; Drug
   Research project of Gansu Provincial Drug Administration [2022GSMPA0011]
FX This work was supported by the Natural Science Foundation of Gansu
   Province of China (22JR5RA507) ; Drug Research project of Gansu
   Provincial Drug Administration (2022GSMPA0011) .
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NR 43
TC 8
Z9 8
U1 0
U2 14
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0045-2068
EI 1090-2120
J9 BIOORG CHEM
JI Bioorganic Chem.
PD SEP
PY 2023
VL 138
AR 106609
DI 10.1016/j.bioorg.2023.106609
EA MAY 2023
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Chemistry
GA I2WJ2
UT WOS:001001433900001
PM 37207595
DA 2026-05-27
ER

PT J
AU Li, JS
   Li, MY
   Yong, CY
   Zhou, ZM
   Han, LC
   Liu, ZM
AF Li, Jishan
   Li, Muyang
   Yong, Chenyu
   Zhou, Zhemin
   Han, Laichuang
   Liu, Zhongmei
TI Reshaping UDP-binding pocket of bacterial sucrose synthase to improve
   efficiency of UDP-glucose production
SO BIORESOURCE TECHNOLOGY
LA English
DT Article
DE Substrate affinity; UDP recycling; Salidroside; Dual-enzyme coupling
ID GLYCOSYLATION; GLYCOSYLTRANSFERASE; IDENTIFICATION
AB UDP-glucose (UDPG), a nucleoside diphosphate sugar, is an important sugar donor for the biosynthesis of various glycoside compounds. Sucrose synthase (SuSy) can catalyze the synthesis of high-value UDPG from the costeffective sucrose. By redesigning the substrate-binding pocket of SuSy in Denitrovibrio acetiphilus DSM 12809, a variant with 8.1-fold increased activity was generated in this study. Structural analysis revealed that the synergistic effect of the newly introduced hydrogen bonds and salt bridges was crucial for the enhanced activity. The yield of UDPG reached 127.6 g/L/h using this variant for catalysis. Moreover, when cascaded with glycosyltransferase for salidroside production, the yield of salidroside increased 2.7-fold, and a UDP recycling number of 3.2 was achieved. These results provide technical support for the industrial application of SuSy in the biosynthesis of nucleotide sugars and glycosides.
C1 [Li, Jishan; Li, Muyang; Yong, Chenyu; Zhou, Zhemin; Han, Laichuang; Liu, Zhongmei] Jiangnan Univ, Sch Biotechnol, Key Lab Ind Biotechnol, Minist Educ, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China.
C3 Jiangnan University
RP Liu, ZM (corresponding author), Jiangnan Univ, Sch Biotechnol, Key Lab Ind Biotechnol, Minist Educ, 1800 Lihu Rd, Wuxi 214122, Jiangsu, Peoples R China.
EM lmeimei1220@hotmail.com
RI Han, Laichuang/HJY-3686-2023
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NR 40
TC 5
Z9 5
U1 11
U2 42
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0960-8524
EI 1873-2976
J9 BIORESOURCE TECHNOL
JI Bioresour. Technol.
PD JUL
PY 2025
VL 427
AR 132396
DI 10.1016/j.biortech.2025.132396
EA MAR 2025
PG 10
WC Agricultural Engineering; Biotechnology & Applied Microbiology; Energy &
   Fuels
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Biotechnology & Applied Microbiology; Energy & Fuels
GA 0IB9W
UT WOS:001447898400001
PM 40090494
DA 2026-05-27
ER

PT J
AU Tang, CL
   Fang, ZL
   Chu, DH
   Zhang, LL
   Tang, YQ
   Zhou, JY
   Fang, R
   Ying, JM
   Wang, F
   Zhou, YP
   Xu, CS
   Wang, QW
AF Tang, Chunlan
   Fang, Zhiling
   Chu, Donghui
   Zhang, Lulu
   Tang, Yuqing
   Zhou, Jinyue
   Fang, Rui
   Ying, Jiaming
   Wang, Fang
   Zhou, Yuping
   Xu, Chunshuang
   Wang, Qinwen
TI Pharmacodynamics, Network Pharmacology, and Pharmacokinetics of Chinese
   Medicine Formula 9002A in the Treatment of Alzheimer's Disease
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE Chinese medicine formula 9002A; Alzheimer's disease; UPLC-MS; MS;
   salidroside; network pharmacology
ID NICOTINAMIDE; DEMENTIA; ESTROGEN
AB Alzheimer's disease (AD) is a common and serious neurodegenerative disease in the elderly; however, the treatment of AD is still lacking of rational drugs. In this paper, the active constituents and targets of the self-developed Chinese medicine Formula 9002A in the treatment of AD were investigated from three aspects: pharmacodynamics based on cell and animal experiments, network pharmacology analysis, and pharmacokinetic analysis. A total of 124 compounds were screened in Formula 9002A, and four constituents including salidroside, gastrodin, niacinamide, and umbelliferone were screened as potential active components for the treatment of AD by network pharmacology. Among them, salidroside and gastrodin showed higher relevance with AD targets, such as ESR1 and AR. The pharmacokinetic study showed that they could be absorbed and identified in plasma; the half-life and mean residence times of salidroside and gastrodin in plasma were nearly increased 2-fold by the administration of Formula 9002A compared with those by the administration of a monomer, indicating the extended action time of active compounds in vivo. Formula 9002A exerted the efficacy in the treatment of AD mainly by regulating APP, GSK3 beta, ESR1, and AR targets based on the anti-beta-amyloid protein deposition, anti-oxidation and anti-apoptosis pathways. Two genes enriched in Alzheimer's disease pathway, APP and GSK3 beta, were further validated. The experiments also demonstrated that Formula 9002A could downregulate APP and GSK3 beta protein expression in the model mice brain and improved their cognitive ability. In summary, Formula 9002A has the characteristics of multiple targets and multiple pathways in the treatment of AD, and salidroside and gastrodin might be the main active constituents, which could provide a foundation for further research and application.
C1 [Tang, Chunlan; Wang, Fang; Zhou, Yuping; Xu, Chunshuang; Wang, Qinwen] Ningbo Univ, Affiliated Hosp, Med Sch, Ningbo, Peoples R China.
   [Tang, Chunlan; Fang, Zhiling; Chu, Donghui; Tang, Yuqing; Zhou, Jinyue; Fang, Rui; Ying, Jiaming; Wang, Qinwen] Ningbo Univ, Sch Med, Ningbo, Peoples R China.
   [Tang, Chunlan] Ningbo Univ, Key Lab Adv Mass Spectrometry & Mol Anal Zhejiang, Ningbo, Peoples R China.
   [Zhang, Lulu] Fudan Univ, State Key Lab Med Neurobiol, Dept Translat Neurosci, Shanghai, Peoples R China.
   [Zhang, Lulu] Fudan Univ, MOE Frontiers Ctr Brain Sci, Inst Brain Sci, Shanghai, Peoples R China.
C3 Ningbo University; Ningbo University; Ningbo University; Fudan
   University; Fudan University
RP Tang, CL; Wang, QW (corresponding author), Ningbo Univ, Affiliated Hosp, Med Sch, Ningbo, Peoples R China.; Tang, CL; Wang, QW (corresponding author), Ningbo Univ, Sch Med, Ningbo, Peoples R China.; Tang, CL (corresponding author), Ningbo Univ, Key Lab Adv Mass Spectrometry & Mol Anal Zhejiang, Ningbo, Peoples R China.
EM chunlant@163.com; wangqinwen@nbu.edu.cn
OI Chu, Donghui/0009-0000-0878-6288
FU Ningbo Natural Science Foundation [2019A610295, 2019A610290]; Opened-End
   Fund of Key Laboratory [2019B10034]; Major Fund Project of Ningbo
   Science and Technology Bureau [202002N3167]; Public Project of Ningbo
   [KFJJ-202101]; K.C. Wong Magna Fund in Ningbo University
FX This work is financially supported by the Ningbo Natural Science
   Foundation (2019A610295; 2019A610290), Opened-End Fund of Key Laboratory
   (KFJJ-202101), the Major Fund Project of Ningbo Science and Technology
   Bureau (2019B10034), and Public Project of Ningbo (202002N3167). In
   addition, the work was also sponsored by a K.C. Wong Magna Fund in
   Ningbo University.
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NR 36
TC 9
Z9 11
U1 2
U2 34
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 8
PY 2022
VL 13
AR 849994
DI 10.3389/fphar.2022.849994
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1A8JY
UT WOS:000791997100001
PM 35462916
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Peschel, W
   Prieto, JM
   Karkour, C
   Williamson, EM
AF Peschel, Wieland
   Prieto, Jose M.
   Karkour, Caroline
   Williamson, Elizabeth M.
TI Effect of provenance, plant part and processing on extract profiles from
   cultivated European Rhodiola rosea L. for medicinal use
SO PHYTOCHEMISTRY
LA English
DT Article
DE Rhodiola rosea L. authentication; Cultivation; Standardisation; Rosavin;
   Salidroside
ID BIOLOGICALLY-ACTIVE COMPOUNDS; RHIZOMES; QUALITY; ROOTS
AB The demand for plant material of Rhodiola rosea L (Crassulaceae) for medicinal use has increased recently, amid concerns about its quality and sustainability. We have analysed the content of phenylpropanoids (total rosavins) and salidroside in liquid extracts from 3-year old cultivated plants of European origin, and mapped the influence of plant part (rhizome versus root), genotype, drying, cutting, and extraction solvent to chemical composition. Rhizomes contained 1.5-4 times more salidroside (0.3-0.4% dry wt) and total rosavins (1.2-3.0%) than roots. The qualitative decisive phenylpropanoid content in the extracts was most influenced by plant part, solvent, and genotype, while drying temperature and cutting conditions were of less importance. We have shown that R. rosea from different boreal European provenances can be grown under temperate conditions and identified factors to obtain consistent high quality extracts provided that authentic germplasm is used and distinguished between rhizome, roots and their mixtures. (c) 2012 Elsevier Ltd. All rights reserved.
C1 [Peschel, Wieland; Prieto, Jose M.; Karkour, Caroline] UCL, Ctr Pharmacognosy & Phytotherapy, Dept Pharmaceut & Biol Chem, Sch Pharm, London WC1N 1AX, England.
   [Peschel, Wieland; Williamson, Elizabeth M.] Univ Reading, Sch Pharm, Reading RG6 6AP, Berks, England.
C3 University of London; University College London; University of London
   School of Pharmacy; University of Reading
RP Peschel, W (corresponding author), UCL, Ctr Pharmacognosy & Phytotherapy, Dept Pharmaceut & Biol Chem, Sch Pharm, 29-39 Brunswick Sq, London WC1N 1AX, England.
EM wieland.peschel@ema.europa.eu
RI Williaon, Elizabeth/D-4679-2011; Prieto, Jose/ABF-8049-2020
OI Williaon, Elizabeth/0000-0003-2034-7063; Prieto,
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NR 24
TC 34
Z9 41
U1 2
U2 58
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9422
J9 PHYTOCHEMISTRY
JI Phytochemistry
PD FEB
PY 2013
VL 86
BP 92
EP 102
DI 10.1016/j.phytochem.2012.10.005
PG 11
WC Biochemistry & Molecular Biology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Plant Sciences
GA 090YY
UT WOS:000315017100010
PM 23137726
DA 2026-05-27
ER

PT J
AU Yuan, Y
   Wu, X
   Zhang, X
   Hong, YL
   Yan, HY
AF Yuan, Yuan
   Wu, Xuan
   Zhang, Xu
   Hong, Yilin
   Yan, Haiyang
TI Ameliorative effect of salidroside from Rhodiola Rosea L. on the
   gut microbiota subject to furan-induced liver injury in a mouse model
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Furan; Salidroside; Gut microbiota; Liver injury
ID HIGH-FAT DIET; MICROCYSTIN-LR; MICE; INFLAMMATION; IL-6
AB In our study, the ameliorative effect of salidroside (SAL) from Rhodiola Rosea L on the intestinal microflora subject to furan-induced liver injury in a mouse model was investigated by 16 S rDNA, oxidative indexes, LPS and cytokine levels. The results demonstrated that SAL alleviated hepatic oxidative injury by inhibiting the activities of AST, ALT and the content of MDA, and promoting the activities of SOD, GSH and GST, compared to the furan-treated group. SAL significantly modified the intestinal microbial diversity and downregulated the circulating levels of serum LPS, IL-6, and TNF-alpha, as well as enhanced the content of IL-10. Importantly, SAL dramatically increased LPS-suppressing bacteria genera Akkermansia, and decreased LPS-producing bacteria phyla Proteobacteria. Our results indicate that SAL supplement restrains intestinal microbial dysbiosis and systemic low-grade inflammation induced by furan. Hopefully, SAL is a potential therapeutical and prophylactic compound in medicament for hepatic diseases.
C1 [Yuan, Yuan; Wu, Xuan; Zhang, Xu; Hong, Yilin; Yan, Haiyang] Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Jilin, Peoples R China.
C3 Jilin University
RP Yan, HY (corresponding author), Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Jilin, Peoples R China.
EM yanhyjlu@163.com
RI Zhang, Xu/NWH-4318-2025; yuan, Yuan/ISA-0923-2023
FU National Natural Science Foundation of China [31471666, 31571939]
FX This work was supported by funds from the National Natural Science
   Foundation of China (No. 31471666, 31571939). The authors gratefully
   acknowledge the fund supports.
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NR 44
TC 63
Z9 63
U1 0
U2 81
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD MAR
PY 2019
VL 125
BP 333
EP 340
DI 10.1016/j.fct.2019.01.007
PG 8
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA HR7AT
UT WOS:000463305000034
PM 30654097
DA 2026-05-27
ER

PT J
AU Guo, JY
   Jiang, S
   Liu, M
   Wang, M
   Han, BB
   Zhang, N
   Liao, YM
   Xiang, YH
   Liu, JX
   Sun, HF
AF Guo, Jiaying
   Jiang, Shan
   Liu, Mei
   Wang, Min
   Han, Beibei
   Zhang, Ning
   Liao, Yumei
   Xiang, Yinhong
   Liu, Jianxin
   Sun, Huifeng
TI Salidroside: A Potential Drug Candidate to Treat Rheumatoid Arthritis
SO MOLECULES
LA English
DT Review
DE salidroside (SAL); rheumatoid arthritis (RA); pharmacological effects;
   anti-inflammatory; immune system
ID AUTOIMMUNE THYROID-DISEASE; AUTONOMIC NERVOUS-SYSTEM; PITUITARY-ADRENAL
   AXIS; MINDFULNESS MEDITATION; NETWORK PHARMACOLOGY; OXIDATIVE STRESS;
   INTERFERON-GAMMA; IN-VITRO; HPA AXIS; ANEMIA
AB Rheumatoid arthritis (RA) is a widespread autoimmune disease that significantly impacts the lives of RA patients. It is often typified as swelling and deformation of small joints, as well as systemic inflammation. Rhodiola rosea has been utilized for millennia to treat various ailments and is known to contain numerous active compounds, including saponins, volatile oils, coumarins, and flavonoids. Recent studies have underscored the pivotal role of salidroside (SAL), a key constituent of Rhodiola rosea L. Modern research indicates that SAL has various pharmacological activities, such as its antioxidant, anti-inflammatory, anti-fatigue, and anti-cancer effects. Despite this, the pathogenesis of RA remains highly complex, and a notable lack exists in overview studies investigating the anti-RA mechanisms of SAL. Therefore, the purpose of this article is to review the present research efforts on the anti-RA mechanisms of SAL and to explore future research prospects for this compound.
C1 [Guo, Jiaying; Jiang, Shan; Wang, Min; Han, Beibei; Zhang, Ning; Sun, Huifeng] Heilongjiang Univ Chinese Med, Sch Pharm, Harbin 150040, Peoples R China.
   [Guo, Jiaying; Liu, Mei; Liao, Yumei; Xiang, Yinhong; Liu, Jianxin] Hunan Univ Med, Sino Pakistan Ctr Tradit Chinese Med, Sch Pharmaceut Sci, Sch Basic Med Sci,China Pakistan Int Sci & Technol, Huaihua 418000, Peoples R China.
C3 Heilongjiang University of Chinese Medicine; Hunan University of
   Medicine
RP Sun, HF (corresponding author), Heilongjiang Univ Chinese Med, Sch Pharm, Harbin 150040, Peoples R China.; Liu, JX (corresponding author), Hunan Univ Med, Sino Pakistan Ctr Tradit Chinese Med, Sch Pharmaceut Sci, Sch Basic Med Sci,China Pakistan Int Sci & Technol, Huaihua 418000, Peoples R China.
EM jiayingguo123@126.com; 18145413520@163.com; m1003573291@126.com;
   wangminmin0123@126.com; han_04133@163.com; zhangning0454@163.com;
   umi11142013@foxmail.com; xiangyh@hnmu.edu.cn; jxliu@hnmu.edu.cn;
   sunhuifeng@hljucm.edu.cn
RI Liu, Jianxin/HDN-1293-2022; Zhang, Ningning/HTS-5168-2023; Guo,
   jiaying/OEP-2922-2025
FU National Science and Technology Major Project of China; National Natural
   Science Foundation of China [8227417]; Major Project of Science,
   Technology Innovation of Hunan Provincial Department of Science and
   Technology [2020SK1020, 2541STC72898]; Jiangsu CM Clinical Innovation
   Center of Degenerative Bone & Joint Disease (General Project) - Huifeng
   Sun, National Science and Technology Major Project of China; 
   [2018ZX09201009]
FX This research was funded by the National Science and Technology Major
   Project of China grant number 2018ZX09201009, the National Natural
   Science Foundation of China grant number 8227417, the Major Project of
   Science, Technology Innovation of Hunan Provincial Department of Science
   and Technology grant number 2020SK1020, In-ternational Cooperative
   Project of Traditional Chinese Medicine grant number 2541STC72898, and
   the Jiangsu CM Clinical Innovation Center of Degenerative Bone & Joint
   Disease (General Project). The APC was funded by Huifeng Sun, National
   Science and Technology Major Project of China. The author would like to
   thank his colleagues at Hunan University of Medicine and Heilongjiang
   University of Chinese Medicine for their contributions and manuscript
   reviews. The author would like to express sincere gratitude to Xia Lei
   from the Wuxi Affiliated Hospital of Nanjing University of Chinese
   Medicine for her valuable support.
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NR 218
TC 4
Z9 4
U1 9
U2 12
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD SEP 24
PY 2025
VL 30
IS 19
AR 3865
DI 10.3390/molecules30193865
PG 28
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 8OU7B
UT WOS:001593762000001
PM 41097287
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Feng, XH
   Wang, WR
   Liu, FS
   Zhang, PL
   Tang, FC
   Zeng, LL
   Tang, KW
AF Feng, Xiaohui
   Wang, Wanru
   Liu, Fusong
   Zhang, Panliang
   Tang, Fengci
   Zeng, Lelin
   Tang, Kewen
TI Separation of active components tyrosol and salidroside from Rhodiola
   rosea crude extract by two-step multistage fractionation extraction
SO CHEMICAL ENGINEERING AND PROCESSING-PROCESS INTENSIFICATION
LA English
DT Article
DE Rhodiola rosea; Active components; Fractional extraction; Tyrosol;
   Salidroside
ID LIQUID-LIQUID-EXTRACTION; REACTIVE EXTRACTION; SOLVENT-EXTRACTION;
   CENTRIFUGAL; ENANTIOMERS; PHASE; ACID; EQUILIBRIUM; CASCADE; WATER
AB Rhodiola rosea contains many active ingredients, such as salidroside and tyrosol. However, separating the active components from Rhodiola rosea crude extract is difficult due to their similar physical properties. Multi-stage centrifugal fractionation extraction method was used due to its strong extraction and separation ability. Three solvents (n-butanol, n-amyl alcohol, and isobutyl acetate) with better distribution coefficient (k) and separation factor (alpha) were selected from nine organic solvents by single-stage extraction experiment. NaCl was used to break the two-phase emulsification during extraction. A two-step multi-stage extraction process was designed to separate multiple components. The multi-stage fractionation extraction experiments were carried out under the theoretical optimum conditions. In the first step, monomer 6 (tyrosol) was isolated and enriched in organic phase with a purity of over 94% using the above three solvents. In the second step using n-butanol as solvent, monomer 3 (picein) was enriched in organic phase with a purity of 93.6%, and monomer 5 (salidroside) was enriched in aqueous phase with a purity of 85.2%. Finally, the effect of the number of stages was simulated for the separation of picein. The yield of picein reached 80%, and the purity was close to 100% by more than 20 stages.
C1 [Feng, Xiaohui; Wang, Wanru; Liu, Fusong; Zhang, Panliang; Tang, Fengci; Zeng, Lelin; Tang, Kewen] Hunan Inst Sci & Technol, Dept Chem & Chem Engn, Yueyang 414006, Hunan, Peoples R China.
C3 Hunan Institute of Science & Technology
RP Zeng, LL; Tang, KW (corresponding author), Hunan Inst Sci & Technol, Dept Chem & Chem Engn, Yueyang 414006, Hunan, Peoples R China.
EM zenglelin2013@126.com; tangkewen@sina.com
RI ; tang, kewen/AFZ-1564-2022
OI Zeng, Lelin/0000-0003-2621-5467; 
FU Innovation Research Group Project of Natural Science Foundation of Hunan
   Province [2020JJ1004]; National Natural Science Foundation of China
   [22178092]; Key Research and Development Project of Hunan Province
   [2020NK2037]; Scientific Research Fund of Hunan Provincial Edu-cation
   Department [20A227]; Hunan Provincial Innovation Foundation for
   Postgraduate [CX20201113]
FX Acknowledgments This work was supported by the Innovation Research Group
   Project of Natural Science Foundation of Hunan Province (No. 2020JJ1004)
   , the National Natural Science Foundation of China (No. 22178092) , the
   Key Research and Development Project of Hunan Province (No. 2020NK2037)
   , the Scientific Research Fund of Hunan Provincial Edu-cation Department
   (No. 20A227) , and the Hunan Provincial Innovation Foundation for
   Postgraduate (No. CX20201113) .
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NR 46
TC 6
Z9 9
U1 2
U2 27
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 0255-2701
EI 1873-3204
J9 CHEM ENG PROCESS
JI Chem. Eng. Process.
PD FEB
PY 2022
VL 172
AR 108800
DI 10.1016/j.cep.2022.108800
EA JAN 2022
PG 11
WC Energy & Fuels; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Energy & Fuels; Engineering
GA 0V1TZ
UT WOS:000788129100003
DA 2026-05-27
ER

PT J
AU Dimpfel, W
   Schombert, L
   Panossian, AG
AF Dimpfel, Wilfried
   Schombert, Leonie
   Panossian, Alexander G.
TI Assessing the Quality and Potential Efficacy of Commercial Extracts of
   Rhodiola rosea L. by Analyzing the Salidroside and Rosavin
   Content and the Electrophysiological Activity in Hippocampal Long-Term
   Potentiation, a Synaptic Model of Memory
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE Rhodiola rosea; saiidroside; rosavin; long-term potentiation;
   hippocampus; quality control; UPLC
ID IN-VITRO INHIBITION; DOUBLE-BLIND; COGNITIVE IMPAIRMENT; STRESS; SHR-5;
   ADAPTOGENS; PLACEBO; FATIGUE; CELLS; TRANSMISSION
AB Rhodiola rosea L. roots and rhizome extracts are active ingredients in adaptogenic herbal medicinal products (HMP) and dietary supplements for temporary relief of symptoms of stress, such as fatigue and weakness.R.rosea extract has a stimulating effect on the CNS, suggesting potential benefits on cognitive functions, memory, learning, and attention. The reproducible efficacy and quality of preparations of the underground parts of R. rosea depend on the highly variable content of the active markers, salidroside and rosavin, which affect the quality of HMP and dietary supplements. However, it is not clear which analytical markers are important for assessing the efficacy of R. rosea preparations intended for use in aging-induced mild cognitive disorders, such as attenuated memory, attention, and learning.Furthermore the activity of various commercial R. rosea extracts has not been correlated with their content. Here, the biological activities of salidroside, rosavin, and seven commercial extracts of underground parts of R. rosea were assessed using a synaptic model of memory:long-term potentiation (LTP) of synaptic transmission in hippocampus slices. A high degree of variation in the content of all active markers was observed. One extract from China lacked rosavin, and there was even variation in the extracts from the Altai geographic region. In vitro, rosavin, salidroside and all tested R. rosea extracts potentiated electric stimulation of an intra-hippocampal electric circuit, which resulted in higher responses of the pyramidal cells in isolated hippocampus slices. Rosavin was more active at higher concentrations than salidroside; while, salidroside was more effective at lower concentrations. The highest content of both active markers was found in the extracts that were active at the lowest concentrations tested; while, some extracts contained some other compounds that presumably reduced the efficacy due to antagonistic interactions. Standardized content of active markers is necessary for the quality control of herbal preparations containing R. rosea extracts, but insufficient for assessment of their potential efficacy. Additional bioassays are needed to assure the reproducible pharmacological activity of R. rosea extracts; therefore, the LTP of synaptic transmission in hippocampus slices may serve as a validation tool for the quality control of R. rosea extracts.
C1 [Dimpfel, Wilfried] Justus Liebig Univ Giessen, Dept Pharmacol, Giessen, Germany.
   [Schombert, Leonie] NeuroCode AG, Wetzlar, Germany.
   [Panossian, Alexander G.] EuroPharma USA Inc, Green Bay, WI 54311 USA.
C3 Justus Liebig University Giessen
RP Dimpfel, W (corresponding author), Justus Liebig Univ Giessen, Dept Pharmacol, Giessen, Germany.; Panossian, AG (corresponding author), EuroPharma USA Inc, Green Bay, WI 54311 USA.
EM w.dimpfel@neurocode-ag.com; apanossian@europharmausa.com
RI Panossian, Alexander/AAK-8720-2021
OI Panossian, Alexander/0000-0002-8467-4525
FU EuroPharma USA; EuroPharma USA Inc.
FX This work was supported by the EuroPharma USA. Sponsor of the research:
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NR 60
TC 39
Z9 49
U1 0
U2 28
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAY 24
PY 2018
VL 9
AR 425
DI 10.3389/fphar.2018.00425
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GG8FV
UT WOS:000432934100001
PM 29881348
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Tian, X
   Huang, Y
   Zhang, XF
   Fang, R
   Feng, Y
   Zhang, WF
   Li, L
   Li, T
AF Tian, Xin
   Huang, Ye
   Zhang, Xiaofeng
   Fang, Rong
   Feng, Yi
   Zhang, Wanfang
   Li, Ling
   Li, Tian
TI Salidroside attenuates myocardial ischemia/reperfusion injury via
   AMPK-induced suppression of endoplasmic reticulum stress and
   mitochondrial fission
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE Salidroside; AMPK; Myocardial ischemia; reperfusion injury; Endoplasmic
   reticulum stress; Apoptosis; Mitochondrial fission
ID ACTIVATED PROTEIN-KINASE; ISCHEMIA-REPERFUSION INJURY; ER STRESS;
   THERAPEUTIC TARGETS; FUSION; RATS; DRP1; PHOSPHORYLATION; MECHANISM;
   DISEASE
AB Ischemic heart disease (IHD) is the primary cause of death worldwide. Salidroside (Sal), the major active compound derived from Rhodiola rosea, is believed to have cardioprotective effects. AMP-activated protein kinase (AMPK), is a pivotal AMP-activated protein kinase in energy metabolism. Whether Sal plays an antiendoplasmic reticulum stress/mitochondrial fission role through AMPK remains elusive. In this study, we established a myocardial ischemia/reperfusion (I/R) rat model. Rat hearts exposed to Sal with or without compound C were then subjected to I/R. Further, H9c2 cardiomyocytes were subjected to simulated ischemia/ reperfusion (SIR) by hypoxia-reoxygenation. The rats and cardiomyocytes were pretreated with Sal, followed by Compound C and AMPK-siRNA to block AMPK activity. We found that Sal significantly ameliorated cardiac function, mitigated infarct size and serum content of lactate dehydrogenase and creatine kinase, improved mitochondrial function, and reduced mitochondrial fission and apoptosis. Furthermore, in cultured H9c2 cardiomyocytes, Sal increased the cell viability and inhibited SIR-induced myocardial apoptosis and mitochondrial fission. Furthermore, the translocation of Drp1 from the cytoplasm to mitochondria induced by salidroside was confirmed both in vivo and in vitro. However, the use of Compound C or AMPK siRNA to block AMPK activity leads to blockade of the protective effects of Sal. In summary, protects against myocardial I/R by activating the AMPK signaling pathway, inhibiting ER stress, and reducing mitochondrial fission and apoptosis.
C1 [Tian, Xin; Li, Ling] Tradit Chinese Med Hosp Shaanxi Prov, Dept Cardiologya, 4 Xihuamen St, Xian 710003, Peoples R China.
   [Huang, Ye] China Acad Chinese Med Sci, Xiyuan Hosp, Dept Emergency, 1 Xiyuan playground St, Beijing 100091, Peoples R China.
   [Zhang, Xiaofeng] Tradit Chinese Med Hosp Shaanxi Prov, Dept Nephrol, 4 Xihuamen St, Xian 710003, Peoples R China.
   [Li, Ling] Tradit Chinese Med Hosp Shaanxi Prov, Dept Geriatr, 4 Xihuamen St, Xian 710003, Peoples R China.
   [Fang, Rong; Feng, Yi; Zhang, Wanfang] Shaanxi Univ Tradit Chinese Med, Sch Grad, 1 Middle Weiyang Rd, Xianyang 712046, Peoples R China.
   [Li, Tian] Fourth Mil Med Univ, Sch Basic Med, 169 Changle West Rd, Xian 710032, Peoples R China.
   [Li, Ling; Li, Tian] Tradit Chinese Med Hosp Shaanxi Prov, Dept Cardiol, 4 Xihuamen St, Xian 710003, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Xiyuan Hospital, CACMS;
   Shaanxi University of Chinese Medicine; Air Force Medical University
RP Li, L; Li, T (corresponding author), Tradit Chinese Med Hosp Shaanxi Prov, Dept Cardiol, 4 Xihuamen St, Xian 710003, Peoples R China.
EM linghu_20062009@126.com; fmmult@foxmail.com
RI Li, Tian/ADZ-3422-2022; Zhang, Wanfang/MFH-2941-2025; Tian,
   Xin/O-5779-2015
OI Tian, Xin/0000-0003-2593-4208
FU National Natural Science Foundation of China [81873201]; Natural Science
   Basic Research Program of Shaanxi [2022JM-473]; Key Research and
   Development Pro-of Shaanxi [2017SF-352]; National Natural Science
   Foundation of China [81873201]; Natural Science Basic Research Program
   of Shaanxi [2022JM-473]; Key Research and Development Program of Shaanxi
   [2017SF-352]
FX This study was funded by the National Natural Science Foundation of
   China (81873201), the Natural Science Basic Research Program of Shaanxi
   (2022JM-473), and the Key Research and Development Program of Shaanxi
   (2017SF-352).
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NR 58
TC 53
Z9 65
U1 2
U2 22
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD AUG 1
PY 2022
VL 448
AR 116093
DI 10.1016/j.taap.2022.116093
EA JUN 2022
PG 13
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA 1Z1EG
UT WOS:000808574700001
PM 35659894
DA 2026-05-27
ER

PT J
AU Zhang, ZY
   Chen, JY
   Liang, ZZ
   Shao, WM
   Gao, Z
   Wu, B
   He, BF
   Schenk, G
AF Zhang, Ziyu
   Chen, Jingyi
   Liang, Zuozhi
   Shao, Wenming
   Gao, Zhen
   Wu, Bin
   He, Bingfang
   Schenk, Gerhard
TI Tailoring Regioselectivity-Controlled UDP-Glycosyltransferase for
   Bidirectional Glycosylation of Tyrosol via Free Energy-Driven Pocket
   Reshaping and Tunnel Engineering
SO ADVANCED SCIENCE
LA English
DT Article
DE free-energy landscape; icariside D2; protein engineering; salidroside;
   UDP-Glycosyltransferase
ID SALIDROSIDE; GLUCOSIDES
AB UDP-glycosyltransferases (UGTs) are pivotal biocatalysts for synthesizing pharmaceutically valuable active components; however, their application is frequently constrained by poor regioselectivity and suboptimal catalytic efficiency. In this study, a tailored, free energy-driven, substrate-binding pocket reshaping strategy is implemented to pinpoint the specific residues in UGTBL1 that control bidirectional regioselective glycosylation of tyrosol, enabling the synthesis of salidroside and icariside D2 without the need for large-scale screening. Additionally, modifications in the tunnel lead to two strictly regioselective mutants with improved catalytic efficiency due to the faster release of the products. Remarkably, while wild-type UGTBL1 exhibits poor regioselectivity toward the alcoholic and phenolic hydroxyl groups of tyrosol, generating an almost equal mixture of products (1:1 ratio), mutant M2 achieved 99.2% regioselectivity toward the alcoholic hydroxyl group of tyrosol, coupled with a 14.8-fold enhancement in catalytic efficiency for salidroside production. Similarly, mutant M2-1 displays 99.1% regioselectivity toward the phenolic hydroxyl group, along with a 3.6-fold improvement in catalytic efficiency for icariside D2 synthesis. Molecular dynamics simulations reveal details about the mechanism for improved regioselectivity and catalytic efficiency. This work provides important insights for protein engineering of UDP-glycosyltransferase with the spacious active pocket in constructing small but smart mutant libraries.
C1 [Zhang, Ziyu; Chen, Jingyi; Liang, Zuozhi; Shao, Wenming; Gao, Zhen; Wu, Bin] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, 30 Puzhunan Rd, Nanjing 211816, Peoples R China.
   [He, Bingfang] Nanjing Tech Univ, Sch Pharmaceut Sci, 30 Puzhunan Rd, Nanjing 211816, Peoples R China.
   [Schenk, Gerhard] Univ Queensland, Sch Chem & Mol Biosci, Brisbane, Qld 4072, Australia.
C3 Nanjing Tech University; Nanjing Tech University; University of
   Queensland
RP Gao, Z; Wu, B (corresponding author), Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, 30 Puzhunan Rd, Nanjing 211816, Peoples R China.
EM gaozhen@njtech.edu.cn; wubin1977@njtech.edu.cn
OI Wu, Bin/0000-0003-3785-1266
FU National Natural Science Foundation of China; Basic Research Program of
   Jiangsu Province [BK20233003]; Nanjing Tech University;  [22478189]
FX This study was financially supported by the National Natural Science
   Foundation of China (22478189) and Basic Research Program of Jiangsu
   Province (No. BK20233003). The authors are also grateful to the
   High-Performance Computing Center of Nanjing Tech University for
   supporting the computational resources.
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NR 48
TC 5
Z9 5
U1 23
U2 52
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
EI 2198-3844
J9 ADV SCI
JI Adv. Sci.
PD OCT 1
PY 2025
VL 12
IS 40
AR e09814
DI 10.1002/advs.202509814
EA AUG 2025
PG 13
WC Chemistry, Multidisciplinary; Nanoscience & Nanotechnology; Materials
   Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science
GA 9DR3W
UT WOS:001542908300001
PM 40755425
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Fan, H
   Su, BJ
   Le, JW
   Zhu, JH
AF Fan, Heng
   Su, Bin-jie
   Le, Jian-wei
   Zhu, Jian-hua
TI Salidroside Protects Acute Kidney Injury in Septic Rats by Inhibiting
   Inflammation and Apoptosis
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Article
DE salidroside; acute kidney injury; sepsis; apoptosis; inflammation
ID SEPSIS; PATHOPHYSIOLOGY; MECHANISMS; MICE
AB Purpose: To clarify the protective effect and mechanism of salidroside (SLDS) on acute kidney injury (AKI) in septic rats.
   Methods: We pretreated rats with different doses of SLDS and analyzed the impact of SLDS on the survival of septic rats. We evaluated the levels of inflammatory factors in rats, the expression of NF-kappa B p65 in the kidney, and the apoptosis of kidney tubular epithelial cells (KTECs).
   Results: SLDS significantly decreased the mortality of septic rats, and it reduced the levels of TNF-alpha, IL-1 beta, and IL-17A in plasma and kidneys and decreased the levels of serum creatinine, plasma renal injury molecule-1 and plasma neutrophil gelatin-associated lipocalin. Moreover, SLDS could significantly decrease the expression of NF-kappa B p65 in kidney tissues and the apoptotic number of KETCs, while reducing the mRNA levels of Caspase-3 and Bax mRNA, and increasing the level of Bcl-2 mRNA.
   Conclusion: SLDS pretreatment protects against AKI in septic rats by inhibiting the inflammation of kidney and the apoptosis of KTECs.
C1 [Fan, Heng; Le, Jian-wei; Zhu, Jian-hua] Ningbo First Hosp, Dept Intens Care Unit, 59 Liuting Rd, Ningbo 315010, Zhejiang, Peoples R China.
   [Su, Bin-jie] Ningbo First Hosp, Dept Intens Care Unit, Haishu Branch, Ningbo, Zhejiang, Peoples R China.
C3 Ningbo University; Ningbo University
RP Zhu, JH (corresponding author), Ningbo First Hosp, Dept Intens Care Unit, 59 Liuting Rd, Ningbo 315010, Zhejiang, Peoples R China.
EM zhujianhua201107@163.com
OI Zhu, Jian-hua/0000-0003-0780-7168
FU Zhejiang Provincial Medical and Health Science Fund of China
   [2021KY998]; Natural Science Foundation of Ningbo [202003N4237]
FX This research was supported by the Zhejiang Provincial Medical and
   Health Science Fund of China under Grant No. 2021KY998, and Natural
   Science Foundation of Ningbo under Grant No. 202003N4237.
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NR 30
TC 24
Z9 29
U1 0
U2 7
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2022
VL 16
BP 899
EP 907
DI 10.2147/DDDT.S361972
PG 9
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 0O9MS
UT WOS:000783848300005
PM 35386851
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Hu, GS
   Hur, YJ
   Jia, JM
   Lee, JH
   Chung, YS
   Yi, YB
   Yun, DJ
   Park, SK
   Kim, DH
AF Hu, Gao Sheng
   Hur, Yeon Jae
   Jia, Jing Ming
   Lee, Jai Heon
   Chung, Young Soo
   Yi, Young Byung
   Yun, Dae Jin
   Park, Soon Ki
   Kim, Doh Hoon
TI Effects of 2-aminoindan-2-phosphonic acid treatment on the accumulation
   of salidroside and four phenylethanoid glycosides in suspension cell
   culture of Cistanche deserticola
SO PLANT CELL REPORTS
LA English
DT Article
DE Cistanche deserticola; Suspension cell culture; Phenylethanoid
   glycosides; 2-Aminoindan-2-phosphonic acid (AIP); PAL activity;
   Biosynthesis; Salidroside
ID PHENYLPROPANOID GLYCOSIDES; 1-METHYL-4-PHENYLPYRIDINIUM ION;
   CONSTITUENTS; HERBA; SALSA; BIOSYNTHESIS; IMPROVEMENT; APOPTOSIS
AB 2-Aminoindan-2-phosphonic acid (AIP), a specific competitive phenylalanine ammonia lyase (PAL) inhibitor was applied to a suspension cell culture of Cistanche deserticola. The effects of AIP treatment on cell growth, PAL activity, contents and yields of total phenolic compound, salidroside and four phenylethanoid glycosides (PheGs) are investigated. The results demonstrated that, 0.5 and 2.0 mu M AIP treatments had similar effects on the measurements investigated in this study. AIP treatment resulted in significant decreases in PAL activity, total phenolic compounds content, and PheGs content. Linear regression analysis showed that PAL activity had a high correlation coefficient with the total phenolic compound content and the four PheGs contents. Total PAL activity-time area under curve (AUC) had a high correlation coefficient with the total phenolic compound yield and the yields of five tested compounds in untreated cell samples. In AIP-treated cells, total PAL activity-time AUC retained a high correlation with the total phenolic compound yield and the yields of three tested compounds, echinacoside, acteoside, and tubuloside A, but not salidroside and cistanoside A. The difference could be caused by the different biosynthetic origins of each of the tested compounds. These results demonstrate the important role of PAL in the biosynthesis of PheGs in the suspension cell culture of C. deserticola.
C1 [Hu, Gao Sheng; Hur, Yeon Jae; Lee, Jai Heon; Chung, Young Soo; Yi, Young Byung; Kim, Doh Hoon] Dong A Univ, Coll Life Sci & Nat Resources, Pusan 604714, South Korea.
   [Jia, Jing Ming] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, Peoples R China.
   [Jia, Jing Ming; Kim, Doh Hoon] Shenyang Pharmaceut Univ, Joint Lab, Shenyang 110016, Peoples R China.
   [Jia, Jing Ming; Kim, Doh Hoon] Dong A Univ, Shenyang 110016, Peoples R China.
   [Yun, Dae Jin] Gyeongsang Natl Univ, Div Appl Life Sci, Jinju 660701, South Korea.
   [Park, Soon Ki] Kyungpook Natl Univ, Div Plant Biosci, Taegu 702701, South Korea.
C3 Dong A University; Shenyang Pharmaceutical University; Shenyang
   Pharmaceutical University; Gyeongsang National University; Kyungpook
   National University (KNU)
RP Kim, DH (corresponding author), Dong A Univ, Coll Life Sci & Nat Resources, Pusan 604714, South Korea.
EM dhkim@dau.ac.kr
OI Yun, Dae-Jin/0000-0002-3638-6043
FU Dong-A University
FX This work was supported by the Dong-A University research fund. We would
   like to thank Professor Jerry Zon who works at the Institute of Organic
   Chemistry Biochemistry and Biotechnology, Wroclaw University of
   Technology in Poland for providing us AIP. We also would like to show
   our appreciation to Dr. Nobuhisa Ezaki at the Yomeishu Seizo Company in
   Japan for giving us standard compounds cistanoside A, acteoside and
   tubuloside A for our experiments.
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NR 25
TC 14
Z9 23
U1 1
U2 51
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0721-7714
EI 1432-203X
J9 PLANT CELL REP
JI Plant Cell Reports
PD APR
PY 2011
VL 30
IS 4
BP 665
EP 674
DI 10.1007/s00299-010-0997-3
PG 10
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA 735ES
UT WOS:000288396800019
PM 21243361
DA 2026-05-27
ER

PT J
AU Rattan, S
   Kumar, A
   Kumar, D
   Warghat, AR
AF Rattan, Shiv
   Kumar, Anil
   Kumar, Dinesh
   Warghat, Ashish R.
TI Enhanced Production of Phenylethanoids Mediated Through Synergistic
   Approach of Precursor Feeding and Light Regime in Cell Suspension
   Culture of Rhodiola imbricata (Edgew.)
SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
LA English
DT Article
DE Rhodiola imbricata; Cell suspension culture; Light regimes; Precursor
   feeding; Total phenolics content; Salidroside
ID SECONDARY METABOLITES PRODUCTION; PLANT-GROWTH REGULATORS; SALIDROSIDE
   PRODUCTION; ANTIOXIDANT ACTIVITY; BIOSYNTHESIS; BIOTRANSFORMATION;
   SACHALINENSIS; ACCUMULATION; ROSEA; GLUCOSYLTRANSFERASE
AB Precursor feeding is a potential strategy for increasing specialized metabolite production in plant cell culture systems. In the present study, cell suspension cultures were developed and subsequently evaluated for precursor feeding investigations. Cell suspension cultures were established in Murashige and Skoog (MS) medium containing 0.5 mg/L thidiazuron (TDZ) + 1 mg/L alpha-naphthalene acetic acid (NAA). The growth biomass and metabolite pattern were analyzed to identify specific culture days required for prolific biomass production. The maximum cell dry weight (DW) was observed in leaf cell suspension (1.22 g/100 mL) and root cell suspension culture (1.12 g/100 mL) on day 21. Afterward, the effect of precursor concentrations (tyrosol; 0.5, 1, 2, and 3 mM) along with two light regimes, photoperiod (16L/8D h, 70 mu mol/m(2)/s) and dark (24 h), was evaluated for cell growth and metabolite accumulation. The results revealed that leaf cell suspension treated with 3 mM tyrosol concentration detected maximum salidroside content (26.05 mg/g DW) on day 15, incubated under photoperiod (16L/8D h) condition. Similarly, under photoperiod (16L/8D h), root cell suspension treated with 3 mM tyrosol produced maximum salidroside content (26.62 mg/g DW) on day 12. Moreover, the total phenolics content increased significantly (44.21 mg/g DW) on day 12 in 3 mM tyrosol treatment under photoperiod (16L/8D h). However, precursor concentrations did not influence the total flavonoids content. The present investigation suggests that the immediate pathway precursor, tyrosol, has a strong effect on enhanced production of salidroside, irrespective of explant type and light regimes.
C1 [Rattan, Shiv; Warghat, Ashish R.] CSIR Inst Himalayan Bioresource Technol, Biotechnol Div, Palampur 176061, Himachal Prades, India.
   [Rattan, Shiv; Kumar, Anil; Kumar, Dinesh; Warghat, Ashish R.] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India.
   [Kumar, Anil; Kumar, Dinesh] CSIR Inst Himalayan Bioresource Technol, Chem Technol Div, Palampur 176061, Himachal Prades, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Himalayan Bioresource Technology (IHBT); Academy of
   Scientific & Innovative Research (AcSIR); Council of Scientific &
   Industrial Research (CSIR) - India; CSIR - Institute of Himalayan
   Bioresource Technology (IHBT)
RP Warghat, AR (corresponding author), CSIR Inst Himalayan Bioresource Technol, Biotechnol Div, Palampur 176061, Himachal Prades, India.; Warghat, AR (corresponding author), Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India.
EM ashishwarghat@ihbt.res.in
RI ; Kumar, Dinesh/F-5081-2015; Warghat, Ashish/AAS-6726-2020
OI Kumar, Anil/0000-0003-1939-0312; negi, Shivrattan/0000-0002-3896-0811;
   Kumar, Dinesh/0000-0003-4123-0235; Warghat, Ashish/0000-0001-5867-3329
FU Council of Scientific and Industrial Research (CSIR), Government of
   India, under the project "Biotechnological interventions for sustainable
   bio-economy generation through characterization, conservation,
   prospection, and utilization of Himalayan bioresourc [MLP-0201];
   National Medicinal Plants Board (NMPB), "Development of Probiotics for
   Plant Tissue Culture Boosting the performance of micro propagated plant
   materials by supplementing plant associated useful endophytes"
   [GAP-0274]
FX The authors acknowledge the Council of Scientific and Industrial
   Research (CSIR), Government of India, under the project
   "Biotechnological interventions for sustainable bio-economy generation
   through characterization, conservation, prospection, and utilization of
   Himalayan bioresources" (MLP-0201) and National Medicinal Plants Board
   (NMPB), "Development of Probiotics for Plant Tissue Culture Boosting the
   performance of micro propagated plant materials by supplementing plant
   associated useful endophytes" (GAP-0274) for providing financial
   support.
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NR 45
TC 10
Z9 11
U1 3
U2 20
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0273-2289
EI 1559-0291
J9 APPL BIOCHEM BIOTECH
JI Appl. Biochem. Biotechnol.
PD JUL
PY 2022
VL 194
IS 7
BP 3242
EP 3260
DI 10.1007/s12010-022-03914-8
EA MAR 2022
PG 19
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA 2E8YK
UT WOS:000776395700010
PM 35349081
DA 2026-05-27
ER

PT J
AU Rattan, S
   Sood, A
   Kumar, P
   Kumar, A
   Kumar, D
   Warghat, AR
AF Rattan, Shiv
   Sood, Archit
   Kumar, Pankaj
   Kumar, Anil
   Kumar, Dinesh
   Warghat, Ashish R.
TI Phenylethanoids, phenylpropanoids, and phenolic acids quantification
   vis-a-vis gene expression profiling in leaf and root derived callus
   lines of Rhodiola imbricata (Edgew.)
SO INDUSTRIAL CROPS AND PRODUCTS
LA English
DT Article
DE Rhodiola imbricata; Callus ageing; Scanning electron microscopy;
   UPLC-PDA; Salidroside; RT-qPCR
ID ROSEA L.; SALIDROSIDE BIOSYNTHESIS; PHYTOCHEMICAL ANALYSIS; ANTIOXIDANT;
   CULTURE; EXTRACT; PATHWAY; QUALITY; TYROSOL
AB Salidroside and rosavins have been found as the most potent ingredients used in Rhodiola based herbal formulations. Rhodiola imbricata is a medicinal herb of the trans-Himalayan Ladakh region of India. Since, the natural supply of this herb is rapidly decreasing, due to its over-exploitation, high altitude region, and traditional usage in the Amchi system of medicine. In the present study, friable callus culture was developed for the first time from leaf and root explants of R. imbricata. Furthermore, callus cell lines were also evaluated for rapid growth rate and high metabolite accumulation. The results revealed that callus induction frequency observed in juvenile leaves (100 %) and roots (87.50 %) in MS medium enriched with 0.5 mg/L TDZ and 1 mg/L NAA. Scanning electron microscopy (SEM) analysis was done for histological observations of the callus surface. A selective and efficient ultra-performance liquid chromatography with PDA detector (UPLC-PDA) method was developed and validated for the quantification of phenylethanoids, phenylpropanoids, and phenolic acids. The maximum salidroside was detected in leaf derived friable green calli (3.59 mg/g DW) subsequently followed by leaf derived friable white calli (2.31 mg/g DW). While rosavin and rosarin were detected maximum in root derived compact green calli (0.15 mg/g DW) and root derived friable green calli (0.07 mg/g DW). Genes encoding enzymes involved in salidroside and rosavins biosynthesis were also investigated for transcript abundance in wild as well as in vitro cultures using the RT-qPCR approach. The present study explained the friable callus culture as a potential alternative approach to obtain higher metabolite yield in R. imbricata. Further, it can be used for sequential scale-up of metabolite at bioreactor level to meet the industrial demand.
C1 [Rattan, Shiv; Sood, Archit; Kumar, Pankaj; Warghat, Ashish R.] CSIR Inst Himalayan Bioresource Technol, Cell & Tissue Engn Lab, Biotechnol Div, Palampur, Himachal Prades, India.
   [Rattan, Shiv; Kumar, Dinesh; Warghat, Ashish R.] Acad Sci & Innovat Res, New Delhi, India.
   [Kumar, Anil; Kumar, Dinesh] CSIR Inst Himalayan Bioresource Technol, Nat Prod Chem & Proc Dev Div, Palampur, Himachal Prades, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Himalayan Bioresource Technology (IHBT); Academy of
   Scientific & Innovative Research (AcSIR); Council of Scientific &
   Industrial Research (CSIR) - India; CSIR - Institute of Himalayan
   Bioresource Technology (IHBT)
RP Kumar, D; Warghat, AR (corresponding author), CSIR Inst Himalayan Bioresource Technol, Palampur 176061, Himachal Prades, India.
EM dineshkumar@ihbt.res.in; ashishwarghat@ihbt.res.in
RI ; Kumar, Dinesh/F-5081-2015; Kumar, Pankaj/AAQ-8181-2021; Sood,
   Archit/HJH-5767-2023; Warghat, Ashish/AAS-6726-2020
OI Kumar, Anil/0000-0003-1939-0312; Sood, Archit/0000-0001-6124-471X;
   Kumar, Anil/0000-0002-2261-9686; Warghat, Ashish/0000-0001-5867-3329
FU Council of Scientific and Industrial Research (CSIR), Government of
   India, under the project "Biotechnological interventions for sustainable
   bio-economy generation through characterization, conservation,
   prospection, and utilization of Himalayan bioresourc [MLP-0201]; UGC,
   New Delhi
FX The authors acknowledge the Council of Scientific and Industrial
   Research (CSIR), Government of India, under the project
   "Biotechnological interventions for sustainable bio-economy generation
   through characterization, conservation, prospection, and utilization of
   Himalayan bioresources (MLP-0201)" for providing financial support. SR
   acknowledges UGC, New Delhi for providing research fellowship and
   Academy of Scientific and Innovative Research (AcSIR), Government of
   India for Ph.D. enrolment. The authors are thankful to the Director, Dr.
   Sanjay Kumar, CSIR-IHBT for providing necessary facilities. CSIR-IHBT
   publication number for this manuscript is 4540.
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NR 56
TC 22
Z9 24
U1 2
U2 29
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0926-6690
EI 1872-633X
J9 IND CROP PROD
JI Ind. Crop. Prod.
PD OCT 15
PY 2020
VL 154
AR 112708
DI 10.1016/j.indcrop.2020.112708
PG 12
WC Agricultural Engineering; Agronomy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA MS8MD
UT WOS:000554526900084
DA 2026-05-27
ER

PT J
AU Yan, XN
   Liu, J
   Zhu, MX
   Liu, LR
   Chen, YJ
   Zhang, YH
   Feng, MH
   Jia, ZX
   Xiao, HB
AF Yan, Xiaoning
   Liu, Jie
   Zhu, Meixia
   Liu, Lirong
   Chen, Yijun
   Zhang, Yinhuan
   Feng, Menghan
   Jia, Zhixin
   Xiao, Hongbin
TI Salidroside orchestrates metabolic reprogramming by regulating the
   Hif-1α signalling pathway in acute mountain sickness
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE Rhodiola crenulata; lactate; glycolysis; oxidative phosphorylation
ID INDUCED APOPTOSIS; CEREBRAL-ISCHEMIA; HYPOXIA; INFLAMMATION; EXTRACT;
   NEURONS; INJURY
AB Context Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba (Crassulaceae) is used to prevent and treat acute mountain sickness. However, the mechanisms underlying its effects on the central nervous system remain unclear. Objective To investigate the effect of Rhodiola crenulata on cellular metabolism in the central nervous system. Materials and methods The viability and Hif-1 alpha levels of microglia and neurons at 5% O-2 for 1, 3, 5 and 24 h were examined. We performed the binding of salidroside (Sal), rhodiosin, tyrosol and p-hydroxybenzyl alcohol to Hif-1 alpha, Hif-1 alpha, lactate, oxidative phosphorylation and glycolysis assays. Forty male C57BL/6J mice were divided into control and Sal (25, 50 and 100 mg/kg) groups to measure the levels of Hif-1 alpha and lactate. Results Microglia sensed low oxygen levels earlier than neurons, accompanied by elevated expression of Hif-1 alpha protein. Salidroside, rhodiosin, tyrosol, and p-hydroxybenzyl alcohol decreased BV-2 (IC50=1.93 +/- 0.34 mM, 959.74 +/- 10.24 mu M, 7.47 +/- 1.03 and 8.42 +/- 1.63 mM) and PC-12 (IC50=6.89 +/- 0.57 mM, 159.28 +/- 8.89 mu M, 8.65 +/- 1.20 and 8.64 +/- 1.42 mM) viability. They (10 mu M) reduced Hif-1 alpha degradation in BV-2 (3.7-, 2.5-, 2.9- and 2.5-fold) and PC-12 cells (2.8-, 2.8-, 2.3- and 2.0-fold) under normoxia. Salidroside increased glycolytic capacity but attenuated oxidative phosphorylation. Salidroside (50 and 100 mg/kg) treatment increased the protein expression of Hif-1 alpha and the release of lactate in the brain tissue of mice. Conclusions These results suggest that Sal induces metabolic reprogramming by regulating the Hif-1 alpha signalling pathway to activate compensatory responses, which may be the core mechanism underlying the effect of Rhodiola crenulata on the central nervous system.
C1 [Yan, Xiaoning; Zhu, Meixia; Liu, Lirong; Zhang, Yinhuan; Feng, Menghan; Xiao, Hongbin] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing, Peoples R China.
   [Yan, Xiaoning; Liu, Jie; Zhu, Meixia; Liu, Lirong; Chen, Yijun; Zhang, Yinhuan; Feng, Menghan; Jia, Zhixin; Xiao, Hongbin] Beijing Univ Chinese Med, Res Ctr Chinese Med Anal & Transformat, Beijing, Peoples R China.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine
RP Xiao, HB (corresponding author), Beijing Univ Chinese Med, Res Ctr Chinese Med Anal & Transformat, Sch Chinese Mat Med, 166 Daxuedong Rd, Beijing 100029, Peoples R China.
EM hbxiao69@163.com
RI Jia, Zhixin/GNP-4427-2022; /AAG-9556-2019
OI Jia, Zhixin/0000-0003-3849-2234; Yan, Xiaoning/0000-0002-0829-0757; 
FU National Science and Technology Major Project [2019ZX09201004-001-022];
   National Natural Science Foundation of China [81774155]
FX This work was supported by the National Science and Technology Major
   Project under Grant number 2019ZX09201004-001-022 and the National
   Natural Science Foundation of China under Grant number 81774155.
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NR 32
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Z9 24
U1 5
U2 33
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1388-0209
EI 1744-5116
J9 PHARM BIOL
JI Pharm. Biol.
PD JAN 1
PY 2021
VL 59
IS 1
BP 1540
EP 1550
DI 10.1080/13880209.2021.1992449
PG 11
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA WR8ON
UT WOS:000714754500001
PM 34739769
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, CP
   Han, JX
   Marcelina, O
   Nugrahaningrum, DA
   Huang, S
   Zou, MJ
   Wang, GX
   Miyagishi, M
   He, Y
   Wu, SR
   Kasim, V
AF Liu, Caiping
   Han, Jingxuan
   Marcelina, Olivia
   Nugrahaningrum, Dyah Ari
   Huang, Song
   Zou, Meijuan
   Wang, Guixue
   Miyagishi, Makoto
   He, Yun
   Wu, Shourong
   Kasim, Vivi
TI Discovery of Salidroside-Derivated Glycoside Analogues as Novel
   Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia
SO JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
ID PERIPHERAL ARTERIAL-DISEASE; HYPOXIA-INDUCIBLE FACTORS; GROWTH-FACTOR
   GENE; THERAPEUTIC ANGIOGENESIS; MOLECULAR-MECHANISMS; PDGF-BB; HEME
   OXYGENASE-1; IN-VITRO; EXPRESSION; MUSCLE
AB Therapeutic angiogenesis is a potential therapeutic strategy for hind limb ischemia (HLI); however, currently, there are no small-molecule drugs capable of inducing it at the clinical level. Activating the hypoxia-inducible factor-1 (HIF-1) pathway in skeletal muscle induces the secretion of angiogenic factors and thus is an attractive therapeutic angiogenesis strategy. Using salidroside, a natural glycosidic compound as a lead, we performed a structure-activity relationship (SAR) study for developing a more effective and druggable angiogenesis agent. We found a novel glycoside scaffold compound (C-30) with better efficacy than salidroside in enhancing the accumulation of the HIF-1 alpha protein and stimulating the paracrine functions of skeletal muscle cells. This in turn significantly increased the angiogenic potential of vascular endothelial and smooth muscle cells and, subsequently, induced the formation of mature, functional blood vessels in diabetic and nondiabetic HLI mice. Together, this study offers a novel, promising small-molecule-based therapeutic strategy for treating HLI.
C1 [Liu, Caiping; Han, Jingxuan; Marcelina, Olivia; Nugrahaningrum, Dyah Ari; Wang, Guixue; Wu, Shourong; Kasim, Vivi] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China.
   [Liu, Caiping; Han, Jingxuan; Marcelina, Olivia; Nugrahaningrum, Dyah Ari; Wu, Shourong; Kasim, Vivi] Chongqing Univ, Coll Bioengn, 111 Project Lab Biomech & Tissue Repair, Chongqing 400044, Peoples R China.
   [Liu, Caiping; Wang, Guixue; Wu, Shourong; Kasim, Vivi] Chongqing Univ, Coll Bioengn, State & Local Joint Engn Lab Vasc Implants, Chongqing 400044, Peoples R China.
   [Huang, Song; Zou, Meijuan] Shenyang Pharmaceut Univ, Sch Pharm, Dept Pharmaceut, Shenyang 110016, Peoples R China.
   [Miyagishi, Makoto] Natl Inst Adv Ind Sci & Technol, Biomed Res Inst, Mol Composite Med Res Grp, Tsukuba, Ibaraki 3058566, Japan.
   [He, Yun] Chongqing Univ, Sch Pharmaceut Sci, Chongqing 400044, Peoples R China.
C3 Chongqing University; Chongqing University; Chongqing University;
   Shenyang Pharmaceutical University; National Institute of Advanced
   Industrial Science & Technology (AIST); Chongqing University
RP Wu, SR; Kasim, V (corresponding author), Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China.; Wu, SR; Kasim, V (corresponding author), Chongqing Univ, Coll Bioengn, 111 Project Lab Biomech & Tissue Repair, Chongqing 400044, Peoples R China.; Wu, SR; Kasim, V (corresponding author), Chongqing Univ, Coll Bioengn, State & Local Joint Engn Lab Vasc Implants, Chongqing 400044, Peoples R China.; He, Y (corresponding author), Chongqing Univ, Sch Pharmaceut Sci, Chongqing 400044, Peoples R China.
EM yun.he@cqu.edu.cn; shourongwu@cqu.edu.cn; vivikasim@cqu.edu.cn
RI Wang, Guixue/ACN-6343-2022; he, yun/JMB-6362-2023; Kasim,
   Vivi/AID-0964-2022
OI Marcelina, Olivia/0000-0003-0941-3314; Han,
   Jingxuan/0000-0001-5901-4464; Wu, Shourong/0000-0001-9650-5465; Kasim,
   Vivi/0000-0001-9182-8230
FU National Natural Science Foundation of China [12032007]; Natural Science
   Foundation of Chongqing [cstc2018jcyjAX0411, cstc2018jcyjAX0374];
   Fundamental Research Funds for the Central Universities [2019CDQYSW010]
FX This work was supported by grants from the National Natural Science
   Foundation of China (12032007), the Natural Science Foundation of
   Chongqing (cstc2018jcyjAX0411 and cstc2018jcyjAX0374), and the
   Fundamental Research Funds for the Central Universities (2019CDQYSW010).
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NR 81
TC 16
Z9 19
U1 0
U2 34
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-2623
EI 1520-4804
J9 J MED CHEM
JI J. Med. Chem.
PD JAN 13
PY 2022
VL 65
IS 1
BP 135
EP 162
DI 10.1021/acs.jmedchem.1c00947
EA DEC 2021
PG 28
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy
GA ZP6QF
UT WOS:000736850800001
PM 34939794
DA 2026-05-27
ER

PT J
AU Zhdanov, DA
   Ryazanova, TK
   Kurkin, VA
   Kurkina, AV
   Braslavsky, VB
AF Zhdanov, D. A.
   Ryazanova, T. K.
   Kurkin, V. A.
   Kurkina, A. V.
   Braslavsky, V. B.
TI Biotechnological Methods for Obtaining Biologically Active Compounds of
   Rhodiola Rosea L. (A Review)
SO RUSSIAN JOURNAL OF BIOORGANIC CHEMISTRY
LA English
DT Review
DE golden root; Rhodiola rosea L.; callus; phytobiotechnology;
   phenylpropanoids; cinnamic alcohol; rosin; rosavin; p-coumaric alcohol;
   triandrin; simple phenols; salidroside; tyrosol
ID RHIZOGENES-MEDIATED TRANSFORMATION; SALIDROSIDE BIOSYNTHESIS;
   NATURAL-PRODUCTS; CALLUS-CULTURE; HAIRY ROOTS; IN-VITRO; AGROBACTERIUM;
   ESTABLISHMENT; ACCUMULATION; EXTRACT
AB Due to its rich chemical composition including unique biologically active compounds the gold root (Rhodiola rosea L.) is still of interest to researchers all over the world. However, deficiency of the raw material base and metabolome variability are determination the modern development ways of pharmacologically active substances in vitro obtaining. The article summarizes and systematizes the information about of Rhodiola rosea biologically active compounds obtaining, which are most often obtaining from callus tissues. Callus tissue is usually obtaining from leaf explants, and Murashige and Skoog medium with plant growth regulators in various combinations and concentrations is most commonly used for its induction. At the same time, the tissue growth efficiency and target compounds accumulation depends on the intact plant genotype, the precursors presence of these compounds in the medium, elicitors, as well as external influence factors. Recently, a promising direction is the transgenic hairy roots cultivation, which reveals new aspects of synthesis, accumulation and secondary metabolites production regulation. Biosynthesis genetic regulation of significant secondary metabolites is also a promising direction. Numerous studies have demonstrated that salidroside biosynthesis depends on the expression of the TyrDC gene encoding tyrosinedecarboxylase. Consequently, understanding the molecular and genetic mechanisms opens up opportunities for its regulation and metabolic engineering. In this regard, biotechnological methods may be a priority to obtaining salidroside, rosin and their derivatives at higher or at least comparable levels with wild type or cultivated plants. Among the various biotechnological strategies used to increase the accumulation of salidroside and glycosides of cinnamic alcohol in cells and cultures of Rhodiola organs, the approach with the addition of the metabolic precursors to the nutrient medium proved to be the most effective. In vitro cultures, a significant increase in the production of rosin and its derivatives was observed when precursors (cinnamic alcohol, cinnamic acid and cinnamic aldehyde) were added to the medium.
C1 [Zhdanov, D. A.; Ryazanova, T. K.; Kurkin, V. A.; Kurkina, A. V.; Braslavsky, V. B.] Samara State Med Univ, Samara 443099, Russia.
C3 Samara State Medical University
RP Kurkin, VA (corresponding author), Samara State Med Univ, Samara 443099, Russia.
EM v.a.kurkin@samsmu.ru
RI Kurkin, Vladimir/L-7663-2015; Anna, Kurkina/S-8476-2016; /H-3398-2015;
   Braslavskii, Valerii/OZE-0071-2025; Браславский, Валерий/OZE-0071-2025
OI Браславский, Валерий/0000-0001-6681-6107
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NR 92
TC 4
Z9 4
U1 8
U2 22
PU PLEIADES PUBLISHING LTD
PI TORTOLA
PA TROPIC ISLE BLDG, PO BOX 3331. ROAD TOWN, TORTOLA, BRITISH VIRGIN ISL
SN 1068-1620
EI 1608-330X
J9 RUSS J BIOORG CHEM+
JI Russ. J. Bioorg. Chem.
PD DEC
PY 2024
VL 50
IS 7
BP 2691
EP 2710
DI 10.1134/S1068162024070112
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA Q0Q1C
UT WOS:001381829600012
DA 2026-05-27
ER

PT J
AU Rattan, S
   Kumar, P
   Kaur, E
   Sood, A
   Acharya, V
   Warghat, AR
AF Rattan, Shiv
   Kumar, Pankaj
   Kaur, Ekjot
   Sood, Archit
   Acharya, Vishal
   Warghat, Ashish R.
TI Comparative transcriptome and tissue-specific expression analysis of
   genes reveal tissue-cultured plants as an alternative source for
   phenylethanoids and phenylpropanoids in Rhodiola imbricata (Edgew.)
SO GENE
LA English
DT Article
DE Crassulaceae; De novo transcriptome; Tissue-cultured plants;
   Phenylethanoids biosynthesis; Rhodiola imbricata; RT-qPCR
ID SECONDARY METABOLITES PRODUCTION; SALIDROSIDE BIOSYNTHESIS;
   MOLECULAR-CLONING; PATHWAY; DECARBOXYLATION; RECONSTRUCTION; CATALYZES
AB Rhodiola imbricata (Crassulaceae) is a traditional trans-Himalayan endangered medicinal herb with immense therapeutic applications. Over the years, over-exploitation, un-managed harvesting, and lack of captive cultivation procedures persuaded threat to its wild habitat. Plant tissue culture and RNA-Seq-based molecular bioprospection of key regulatory genes aid the understanding of molecular dynamics involved in specialized metabolites (phenylethanoids and phenylpropanoids) biosynthesis and its sustainable production. Hence, comparative transcriptomic analysis was performed using leaf and root tissues from the wild and tissue-cultured plants, revealing tissue-specific production of salidroside and rosavin. The transcriptome profiling resulted in 345 million high-quality reads yielding 92,380 unique transcripts with an N50 of 1260 bp. Tissue-specific gene expression analysis revealed that both phenylethanoids and phenylpropanoids biosynthesis are predominantly associated with the shikimate pathway. In addition to RNA-Seq data, the downstream biosynthesis pathways genes viz., phospho-2-dehydro-3-deoxyheptonate aldolase (DAHPS), 3-dehydroquinate synthase (DHQS), shikimate kinase (SK), chorismate mutase (CM), arogenate dehydrogenase (TYRAAT), aromatic-L-amino-acid decarboxylase (TDC), phenylalanine ammonia-lyase (PAL), 4-coumarate-CoA ligase (4-CL), cinnamoyl-CoA reductase (CCR), and cinnamyl alcohol dehydrogenase (CAD) showed higher expression pattern in wild plant tissues compared to tissuecultured plants. The transcript fold expression determined by RT-qPCR results followed similar patterns as those observed in RNA-seq and targeted metabolite profiling data. Salidroside and rosavin content in wild plants exhibited 2.40 fold and 1.77 fold increase accumulation compared to the tissue-cultured plant. The present investigation explained the tissue and condition-specific significant differences between the expression of proposed biosynthetic pathway genes and salidroside and rosavin content. Additionally, NAC, bHLH, and ARF were the most abundant transcription factor families found in the transcriptomic analysis of R. imbricata. The generated transcriptome dataset provides a valuable gene(s)/transcription factors hub that can be used for the sustainable production of salidroside and rosavin in R. imbricata under tissue culture conditions.
C1 [Rattan, Shiv; Kumar, Pankaj; Kaur, Ekjot; Sood, Archit; Acharya, Vishal; Warghat, Ashish R.] CSIR Inst Himalayan Bioresource Technol, Biotechnol Div, Palampur 176061, Himachal Prades, India.
   [Rattan, Shiv; Kaur, Ekjot; Acharya, Vishal; Warghat, Ashish R.] Acad Sci & Innovat Res AcSIR, Ghaziabad 201002, India.
C3 Council of Scientific & Industrial Research (CSIR) - India; CSIR -
   Institute of Himalayan Bioresource Technology (IHBT); Academy of
   Scientific & Innovative Research (AcSIR)
RP Warghat, AR (corresponding author), CSIR Inst Himalayan Bioresource Technol, Biotechnol Div, Palampur 176061, Himachal Prades, India.
EM ashishwarghat@ihbt.res.in
RI ; Sood, Archit/HJH-5767-2023; Kumar, Pankaj/AAB-4153-2019; Warghat,
   Ashish/AAS-6726-2020
OI , Ekjot Kaur/0009-0004-8892-8977; Sood, Archit/0000-0001-6124-471X;
   ACHARYA, VISHAL/0000-0003-2175-9799
FU Council of Scientific and Industrial Research (CSIR), Government of
   India [MLP-0201]; National Medicinal Plants Board (NMPB), "Development
   of Probiotics for Plant Tissue Culture Boosting the performance of micro
   propagated plant materials by supplementing plant associated useful
   endophytes" [GAP-0274]; Department of Biotechnology, Government of India
   [GAP-0282]
FX The authors acknowledge the Council of Scientific and Industrial
   Research (CSIR), Government of India, under the project
   "Biotechnological interventions for sustainable bio-economy generation
   through characterization, conservation, prospection and utilization of
   Himalayan bioresources" (MLP-0201) and National Medicinal Plants Board
   (NMPB), "Development of Probiotics for Plant Tissue Culture Boosting the
   performance of micro propagated plant materials by supplementing plant
   associated useful endophytes" (GAP-0274) for providing financial
   support. The authors are also thankful to Department of Biotechnology,
   Government of India, for infrastructural support in the form of
   "HiCHiCoB Centre" (GAP-0282).
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NR 58
TC 10
Z9 10
U1 5
U2 34
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-1119
EI 1879-0038
J9 GENE
JI Gene
PD AUG 20
PY 2022
VL 836
AR 146672
DI 10.1016/j.gene.2022.146672
PG 12
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA 2M9IR
UT WOS:000818005300002
PM 35714804
DA 2026-05-27
ER

PT J
AU Liu, S
   Lv, XM
   Wang, D
AF Liu, Song
   Lv, Xiaomeng
   Wang, Dong
TI Study on the Neuroprotective Mechanism of Salidroside Modified with
   Polydopamine Nanoparticles in Regulating Notch Pathway by Inhibiting
   Mir-155 in Stroke Rats
SO PHARMACOGNOSY MAGAZINE
LA English
DT Article
DE Polydopamine; nanoparticles; salidroside; Mir-155; notch pathway;
   stroke; neuroprotection
AB Background and Purpose Stroke threatens neurological function. Salidroside is widely used to treat neurological diseases such as stroke. Previous studies have shown that miR-155 plays an important regulatory role in the pathogenesis of stroke and that the Notch pathway plays an important role in nervous system development and regeneration.Methods PDA NPs-SAL complex was prepared, a stroke rat model was constructed, and the cerebral infarction area of rats was measured. Analyze the changes of PDA NPs-SAL on rat brain tissue and evaluate the neuroprotective effect. Detect the changes in miR-155 and Notch pathway-related proteins in stroke rat models to further understand the role of miR-155 and Notch pathway in the pathogenesis of stroke and their relationship.Results Salidroside had certain protective effects on the nerves of stroke rats, and the effect of PDA NPs-SAL was more prominent. At the same time, PDA NPs-SAL promotes the Notch pathway by inhibiting miR-155, thereby exerting a neuroprotective effect on stroke rats.Conclusion Under the intervention of PDA NPs-SAL, the neurological function scores of rats were reduced, and the effect of PDA NPs-SAL was more significant. In addition, PDA NPs-SAL inhibited miR-155 and activated the Notch pathway, thereby reducing the water content of rat brain tissue and cerebral infarction area, thereby exerting a neuroprotective effect on stroke rats.
C1 [Liu, Song; Lv, Xiaomeng; Wang, Dong] Dongping Peoples Hosp, Dept Neurosurg, 018 Dongshan Rd, Tai An 271500, Shandong, Peoples R China.
RP Wang, D (corresponding author), Dongping Peoples Hosp, Dept Neurosurg, 018 Dongshan Rd, Tai An 271500, Shandong, Peoples R China.
EM 13853873429@163.com
RI Lyu, Xiaomeng/JFS-1841-2023
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NR 25
TC 0
Z9 0
U1 1
U2 4
PU SAGE PUBLICATIONS INDIA  PVT LTD
PI NEW DELHI
PA B-1-I-1 MOHAN CO-OPERATIVE INDUSTRIAL AREA, MATHURA RD, POST BAG NO 7,
   NEW DELHI 110 044, INDIA
SN 0973-1296
EI 0976-4062
J9 PHARMACOGN MAG
JI Pharmacogn. Mag.
PD DEC
PY 2025
VL 21
IS 4
BP 1176
EP 1186
DI 10.1177/09731296241282387
EA OCT 2024
PG 11
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 8IW4L
UT WOS:001336936400001
OA hybrid
DA 2026-05-27
ER

PT J
AU Yang, SX
   Pei, TT
   Wang, LS
   Zeng, Y
   Li, WX
   Yan, SH
   Xiao, W
   Cheng, WD
AF Yang, Sixia
   Pei, Tingting
   Wang, Linshuang
   Zeng, Yi
   Li, Wenxu
   Yan, Shihua
   Xiao, Wei
   Cheng, Weidong
TI Salidroside Alleviates Renal Fibrosis in SAMP8 Mice by Inhibiting
   Ferroptosis
SO MOLECULES
LA English
DT Article
DE renal fibrosis; ferroptosis; aging; salidroside; iron transport
ID SENESCENCE; MODEL
AB Renal fibrosis progression is closely associated with aging, which ultimately leads to renal dysfunction. Salidroside (SAL) is considered to have broad anti-aging effects. However, the roles and mechanisms of SAL in aging-related renal fibrosis remain unclear. The study aimed to evaluate the protective effects and mechanisms of SAL in SAMP8 mice. SAMP8 mice were administered with SAL and Ferrostatin-1 (Fer-1) for 12 weeks. Renal function, renal fibrosis, and ferroptosis in renal tissue were detected. The results showed that elevated blood urea nitrogen (BUN) and serum creatinine (SCr) levels significantly decreased, serum albumin (ALB) levels increased, and mesangial hyperplasia significantly reduced in the SAL group. SAL significantly reduced transforming growth factor-beta (TGF-beta) and alpha-smooth muscle actin (alpha-sma) levels in SAMP8 mice. SAL treatment significantly decreased lipid peroxidation in the kidneys, and regulated iron transport-related proteins and ferroptosis-related proteins. These results suggested that SAL delays renal aging and inhibits aging-related glomerular fibrosis by inhibiting ferroptosis in SAMP8 mice.
C1 [Yang, Sixia; Pei, Tingting; Zeng, Yi; Li, Wenxu; Yan, Shihua; Xiao, Wei; Cheng, Weidong] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China.
   [Wang, Linshuang] China Acad Chinese Med Sci, Inst Basic Res Clin Med, Beijing 100700, Peoples R China.
   [Xiao, Wei] Guangdong Pharmaceut Univ, Key Lab Glucolipid Metab Disorder, Minist Educ, Guangzhou 510006, Peoples R China.
C3 Southern Medical University - China; China Academy of Chinese Medical
   Sciences; Institute of Basic Research In Clinical Medicine, CACMS;
   Guangdong Pharmaceutical University
RP Xiao, W; Cheng, WD (corresponding author), Southern Med Univ, Sch Tradit Chinese Med, Guangzhou 510515, Peoples R China.; Xiao, W (corresponding author), Guangdong Pharmaceut Univ, Key Lab Glucolipid Metab Disorder, Minist Educ, Guangzhou 510006, Peoples R China.
EM xw7688@smu.edu.cn; chengweidong888@sina.com
RI Cheng, Weidong/LMP-6222-2024; Xiao, Wei/KCK-6954-2024
OI Wang, Linshuang/0000-0001-6081-4573; Xiao, Wei/0000-0002-8426-9060
FU National Natural Science Foundation of China [82174149, 81973641,
   81973804]; Administration of Traditional Chinese Medicine Project
   [20200505160744]
FX This research was funded by the National Natural Science Foundation of
   China, (82174149, 81973641, 81973804), the Administration of Traditional
   Chinese Medicine Project (20200505160744).
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NR 47
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Z9 41
U1 2
U2 27
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD NOV
PY 2022
VL 27
IS 22
AR 8039
DI 10.3390/molecules27228039
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6K5AC
UT WOS:000887513800001
PM 36432138
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Mirmazloum, I
   Ladányi, M
   Beinrohr, L
   Kiss-Bába, E
   Kiss, A
   György, Z
AF Mirmazloum, Iman
   Ladanyi, Marta
   Beinrohr, Laszlo
   Kiss-Baba, Erzsebet
   Kiss, Attila
   Gyorgy, Zsuzsanna
TI Identification of a novel UDP-glycosyltransferase
   gene from Rhodiola rosea and its expression during
   biotransformation of upstream precursors in callus culture
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Rhodiola; Salidroside; Biotransformation; UDP-glycosyltransferase;
   Heterologous expression
ID CINNAMYL GLYCOSIDES; AGGREGATE CULTURES; GOLDEN ROOT; SALIDROSIDE;
   OVEREXPRESSION; BIOSYNTHESIS; QUALITY; RNA; L.
AB Roseroot (Rhodiola rosea L.) is a medicinal plant with adaptogenic properties and several pharmaceutically important metabolites. In this study, a full length cDNA encoding a UDPG gene of roseroot was identified, cloned and characterized. Its ORF (1425 bp) was transferred into E. coli, where the expression of the recombinant enzyme was confirmed. To monitor the enzyme activity, 3 precursors (tyramine, 4-hydroxyphenylpyruvate & tyrosol) of salidroside biosynthesis pathway were added to roseroot callus cultures and samples were harvested after 1, 6,12, 24, 48 & 96 h. Along with the controls (without precursor feeding), each sample was subjected to HPLC and qRT-PCR for phytochemical and relative UDP-glycosyltransferase gene expression analysis, respectively. The HPLC analysis showed that the salidroside content significantly increased; reaching 0.5% of the callus dry weight (26-fold higher than the control) after 96 h when 2 mM tyrosol was given to the media. The expression of the UDP-glycosyltransferase increased significantly being the highest at 12 h after the feeding. The effect of tyramine and 4-hydroxyphenylpyruvate was not as pronounced as of tyrosol. Here, we introduce a R. rosea specific UDPG gene and its expression pattern after biotransformation of intermediate precursors in in vitro roseroot callus cultures. (C) 2019 Elsevier B.V. All rights reserved.
C1 [Mirmazloum, Iman; Kiss-Baba, Erzsebet] Szent Istvan Univ, Dept Plant Physiol & Plant Biochem, Budapest, Hungary.
   [Mirmazloum, Iman; Kiss, Attila] Kaposvar Univ, Food Sci Innovat Ctr, Kaposvar, Hungary.
   [Ladanyi, Marta] Szent Istvan Univ, Dept Biometr & Agr Informat, Budapest, Hungary.
   [Beinrohr, Laszlo] Hungarian Acad Sci, Inst Enzymol, Res Ctr Nat Sci, Budapest, Hungary.
   [Gyorgy, Zsuzsanna] Szent Istvan Univ, Dept Genet & Plant Breeding, Budapest, Hungary.
C3 Hungarian University of Agriculture & Life Sciences; Kaposvar
   University; Hungarian University of Agriculture & Life Sciences;
   Hungarian University of Agriculture & Life Sciences; HUN-REN; HUN-REN
   Research Centre for Natural Sciences; Institute of Enzymology - HAS;
   Hungarian Academy of Sciences; Hungarian University of Agriculture &
   Life Sciences
RP Mirmazloum, I (corresponding author), Szent Istvan Univ, Dept Plant Physiol & Plant Biochem, Budapest, Hungary.
EM Mirmazloum.Iman@kertk.szie.hu
RI Mirmazloum, Iman/AAJ-5673-2020; György, Zsuzsanna/L-7105-2016; Ladanyi,
   Marta/AAX-9067-2021; Kiss-Baba, Erzsebet/NVM-8765-2025
OI Mirmazloum, Iman/0000-0002-1461-0382; György,
   Zsuzsanna/0000-0002-7803-5487; Ladanyi, Marta/0000-0003-3114-8289;
   Kiss-Baba, Erzsebet/0000-0002-9716-169X
FU Higher Education Institutional Excellence Program [NKFIH-FK128793];
   Ministry of Human Capacities within the framework of plant breeding and
   plant protection researches of Szent Istvan University, Hungary
   [20430-3/2018/FEKUTSTRAT]
FX This research was supported by NKFIH-FK128793 project and the Higher
   Education Institutional Excellence Program (20430-3/2018/FEKUTSTRAT)
   awarded by the Ministry of Human Capacities within the framework of
   plant breeding and plant protection researches of Szent Istvan
   University, Hungary.
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NR 44
TC 12
Z9 12
U1 4
U2 75
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD SEP 1
PY 2019
VL 136
BP 847
EP 858
DI 10.1016/j.ijbiomac.2019.06.086
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA IT0JR
UT WOS:000482533000086
PM 31226374
DA 2026-05-27
ER

PT J
AU Xu, QB
   Shi, LC
   Kong, WJ
   Wang, J
   Xiao, PG
   Liu, JX
AF Xu, Qingbin
   Shi, Linchun
   Kong, Weijun
   Wang, Jing
   Xiao, Peigen
   Liu, Jinxin
TI A novel bacillus-shaped CoNi ZIF-MXene@MWCNT carbon cloth
   electrochemical sensor for sensitive detection of salidroside
SO MICROCHEMICAL JOURNAL
LA English
DT Article
DE CoNi ZIF-MXene; MWCNT; Carbon cloth; Electrocatalytic; Electrochemical
   sensor; Salidroside
ID ACID
AB A meticulously engineered bacillus-shaped CoNi ZIF-MXene@MWCNT carbon cloth (CC) composite was synthesized through a one-step immersion method, which was employed in the development of a novel electrochemical (EC) sensor for the sensitive detection of salidroside (SAL) in Rhodiola. Characterization of the CoNi ZIF-MXene@MWCNT CC was conducted using scanning electron microscopy (SEM), X-ray photoelectron spectroscopy (XPS), energy-dispersive X-ray spectroscopy (EDS), and EC methods. The bacillus-shaped composite showcased an exceptionally high rate of active site exposure, superior conductivity, and electrocatalytic efficiency, attributed to the synergistic effects of the constituent materials. The remarkable electrocatalytic capability facilitated the redox reaction of SAL, marked by a significant enhancement in the current signal. This led to a concentration-dependent response enabling the quantitative detection of SAL. The mechanism of the redox reaction might be the oxidation of the phenolic hydroxyl group of SAL. Demonstrating high sensitivity, selectivity, and stability, this novel bacillus-shaped composite-based EC sensor achieved a low detection limit (LOD) of 0.0958 mu g/mL for SAL, within an effective linear range of 0.5-500 mu g/mL. Importantly, the EC sensor proved to be adept at practical detection of SAL in Rhodiola samples with complex matrices, and the salidroside content of Rhodiola crenulata was much higher than that of Rhodiola rosea, indicating that Rhodiola crenulata may have a higher medicinal value, offering a promising avenue for rapid and sensitive detection of SAL.
C1 [Xu, Qingbin; Shi, Linchun; Wang, Jing; Xiao, Peigen; Liu, Jinxin] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, State Key Lab Qual Ensurance & Sustainable Use Dao, Beijing 100193, Peoples R China.
   [Kong, Weijun] Capital Med Univ, Sch Tradit Chinese Med, Beijing 100069, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Institute of Medicinal Plant Development - CAMS; Peking Union Medical
   College; Capital Medical University
RP Wang, J; Xiao, PG; Liu, JX (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Plant Dev, State Key Lab Qual Ensurance & Sustainable Use Dao, Beijing 100193, Peoples R China.
EM jwang0305@163.com; pgxiao@implad.ac.cn; liujx_23@163.com
FU Key project at central gov [2060302]; China Postdoctoral Science
   Foundation [2022M720504]
FX We are grateful for the supports from Key project at central gov-
   ernment level: The ability establishment of sustainable use for valuable
   Chinese Medicine Resources (No. 2060302) and China Postdoctoral Science
   Foundation (2022M720504) .
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NR 40
TC 8
Z9 8
U1 3
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0026-265X
EI 1095-9149
J9 MICROCHEM J
JI Microchem J.
PD SEP
PY 2024
VL 204
AR 111055
DI 10.1016/j.microc.2024.111055
EA JUL 2024
PG 9
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA YA2R5
UT WOS:001265703800001
DA 2026-05-27
ER

PT J
AU Bi, YH
   Wang, ZY
   Mao, YY
   Zheng, SY
   Zhang, HJ
   Shi, H
AF Bi Yanhong
   Wang Zhaoyu
   Mao Yanyong
   Zheng Shangyong
   Zhang Haijiang
   Shi Hao
TI Ionic Liquid Effects on the Activity of β-Glycosidase for the Synthesis
   of Salidroside in Co-solvent Systems
SO CHINESE JOURNAL OF CATALYSIS
LA English
DT Article
DE ionic liquid; salidroside; glucosylation; black plum seed meal;
   co-solvent
ID APPLE SEED MEAL; D-GLUCOPYRANOSIDES; ENZYMATIC-SYNTHESIS; ROBUST
   BIOCATALYST; REVERSE HYDROLYSIS; YIELD; GLUCOSIDASE; ALCOHOLS
AB The preparation of salidroside was successfully carried out in fourteen ionic liquids (ILs)-containing systems using beta-glycosidase from black plum seeds for the first time. The optimum conditions were determined for C(6)MIm center dot BF4, pH, phosphate buffer content, and molar ratio of tyrosol to D-glucose to be 1% (v/v), 5.9, 20% (v/v), and 8:1, under which the initial reaction rate and yield were 3.3 mmol/(L.h) and 24.5%, respectively. Moreover, the effects of 1-alkylimidazolium-based ILs possessing different alkyl chain lengths from C-2 to C-10 and a variety of anions including BF4-, PF6-, Cl-, Br-, and I- on enzyme activity in co-solvent systems were investigated. The results indicate that the optimal chain length of the alkyl substituent on the imidazolium ring of the cation was C-6.
C1 [Bi Yanhong; Wang Zhaoyu; Mao Yanyong; Zheng Shangyong; Zhang Haijiang; Shi Hao] Huaiyin Inst Technol, Sch Life Sci & Chem Engn, Huaian 223003, Jiangsu, Peoples R China.
C3 Huaian University
RP Wang, ZY (corresponding author), Huaiyin Inst Technol, Sch Life Sci & Chem Engn, Huaian 223003, Jiangsu, Peoples R China.
EM biowzy@126.com
RI wang, zhaoyu/IQT-3451-2023; Shi, Hao/IQV-8628-2023
OI Shi, Hao/0000-0003-0803-9623
FU Natural Science Research Project of Higher Education of Jiangsu
   [10KJB530001]; Subei Technology and Development Program of Jiangsu
   [BC2010441]; Science and Technology Supporting Program (Industry) of
   Huai'an City [HAG2011005]; Agriculture Supporting Program of Huai'an
   City [SN1143, SN1052]
FX This work was supported by the Natural Science Research Project of
   Higher Education of Jiangsu (10KJB530001), the Subei Technology and
   Development Program of Jiangsu (BC2010441), the Science and Technology
   Supporting Program (Industry) of Huai'an City (HAG2011005), and the
   Agriculture Supporting Program of Huai'an City (SN1143, SN1052).
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NR 21
TC 16
Z9 17
U1 2
U2 50
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, BEIJING 100717, PEOPLES R CHINA
SN 0253-9837
J9 CHINESE J CATAL
JI Chin. J. Catal.
PD JUL
PY 2012
VL 33
IS 7
BP 1161
EP 1165
DI 10.1016/S1872-2067(11)60395-1
PG 5
WC Chemistry, Applied; Chemistry, Physical; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Engineering
GA 977PJ
UT WOS:000306676600015
DA 2026-05-27
ER

PT J
AU Pang, GB
   Hu, KL
   Ji, JY
   Xiong, B
   Han, L
   Pang, J
   Xiang, SL
AF Pang, Guangbao
   Hu, Kunlin
   Ji, Jianyu
   Xiong, Bin
   Han, Lin
   Pang, Jing
   Xiang, Shulin
TI Investigating hub genes in the relationship between septic
   cardiomyopathy and cuproptosis and potential Chinese herbal candidates
   with bioinformatic tools
SO MINERVA CARDIOLOGY AND ANGIOLOGY
LA English
DT Article
DE Cardiomyopathies; Sepsis; Pyruvate dehydrogenase E1 beta subunit; Drugs;
   Chinese herbal
ID COPPER RESTRICTION; SEPSIS; DYSFUNCTION; ALPHA
AB BACKGROUND: The aim of this study was using bioinformatic tools to identify hub genes in the relationship between septic cardiomyopathy (SCM) and cuproptosis and predict potential Chinese herbal drug candidates.<br /> METHODS: SCM datasets were downloaded from the gene expression omnibus. Cuproptosis related genes were collected from a research published on Science in March, 2022. The expression profiles of genes related to cuproptosis in SCM were extracted. Differentially expressed genes (DEGs) were analyzed using R package limma. A single-sample gene set enrichment analysis was conducted to measure the correlation between DEGs and immune cell infiltration. Hub genes were screened out by random forest model. Finally, HERB database and COREMINE database were used to predict Chinese herbal drugs for hub genes and carry out molecular docking.<br /> RESULTS: A total of 9 DEGs were identified. Cuproptosis differential genes PDHB, DLAT, DLD, FDX1, GCSH, LIAS were significantly correlated with one or more cells and their functions in immune infiltration. The random forest model screened pyruvate dehydrogenase E1 beta subunit (PDHB) as the hub gene. PDHB was negatively correlated with Plasmacytoid dendritic cell infiltration. Pyruvic acid, rhodioloside and adenosine were predicted with PDHB as the target, and all three components are able to bind to PDHB.<br /> CONCLUSIONS: Cuproptosis related gene PDHB is associated with the occurrence and immune infiltration of septic cardiomyopathy. Rhodioloside and other Chinese herbal drugs may play a role in the treatment of SCM by regulating the expression of PDHB.
C1 [Pang, Guangbao; Hu, Kunlin; Ji, Jianyu; Xiong, Bin; Han, Lin; Pang, Jing; Xiang, Shulin] Guangxi Acad Med Sci, Peoples Hosp Guangxi Zhuang Autonomous Reg, Res Ctr Communicable & Severe Dis, Intens Care Unit, 6 Taoyuan Rd, Nanning 530016, Guangxi, Peoples R China.
RP Xiang, SL (corresponding author), Guangxi Acad Med Sci, Peoples Hosp Guangxi Zhuang Autonomous Reg, Res Ctr Communicable & Severe Dis, Intens Care Unit, 6 Taoyuan Rd, Nanning 530016, Guangxi, Peoples R China.
EM xiangshulin27@163.com
RI Pang, Jing/T-6397-2019; hu, kunlin/MVT-5989-2025
OI hu, kunlin/0000-0003-1012-2274
FU Research Center of Communicable and Severe Diseases, Guangxi Academy of
   Medical Sciences and Department of Intensive Care Unit, The Peoples
   Hospital of Guangxi Zhuang Autonomous Region [AD22035101]; Role and
   mechanism of metabotropic glutamate receptor activation of Ca2+
   signaling pathway in the increased permeability of pulmonary
   microvascular endothelial cells in ARDS (Natural Science Foundation of
   China) [2023GXNSFAA026161]
FX Research Center of Communicable and Severe Diseases, Guangxi Academy of
   Medical Sciences and Department of Intensive Care Unit, The Peoples
   Hospital of Guangxi Zhuang Autonomous Region (AD22035101) .The role and
   mechanism of metabotropic glutamate receptor activation of Ca2+
   signaling pathway in the increased permeability of pulmonary
   microvascular endothelial cells in ARDS (Natural Science Foundation of
   China, 2023GXNSFAA026161) .
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NR 31
TC 2
Z9 2
U1 0
U2 8
PU EDIZIONI MINERVA MEDICA
PI TURIN
PA CORSO BRAMANTE 83-85 INT JOURNALS DEPT., 10126 TURIN, ITALY
SN 2724-5683
EI 2724-5772
J9 MINERVA CARDIOL ANGI
JI Minerva Cardiol. Angiol.
PD OCT
PY 2024
VL 72
IS 5
BP 453
EP 464
DI 10.23736/S2724-5683.23.06476-1
EA MAY 2024
PG 12
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA K4B4Y
UT WOS:001234967200001
PM 38804624
OA hybrid
DA 2026-05-27
ER

PT J
AU Zhang, LL
   Ding, WJ
   Sun, HX
   Zhou, Q
   Huang, JQ
   Li, XF
   Xie, YH
   Chen, JZ
AF Zhang, Lingling
   Ding, Wenjun
   Sun, Huixing
   Zhou, Qiong
   Huang, JingQun
   Li, Xuefen
   Xie, Yonghong
   Chen, Jianzong
TI Salidroside protects PC12 cells from MPP+-induced apoptosis
   via activation of the PI3K/Akt pathway
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Parkinson's disease; Salidroside; MPP+; PC12 cells; Apoptosis; PI3K/Akt
   signaling pathway
ID PARKINSONS-DISEASE; MICROGLIAL ACTIVATION; OXIDATIVE STRESS;
   EPIGALLOCATECHIN GALLATE; NEUROBLASTOMA-CELLS; HIPPOCAMPAL-NEURONS;
   HEMATOPOIETIC-CELLS; MEMBRANE ASYMMETRY; SIGNALING PATHWAYS;
   SUBSTANTIA-NIGRA
AB Oxidative stress plays an important role in the pathogenesis of Parkinson's disease (PD). Salidroside (SAL), a phenylpropanoid glycoside isolated from Rhodiola rosea L, can exert potent antioxidant properties. In this study, we investigated the protective effects, and the possible mechanism of action, of SAL against 1-methyl-4-phenylpyridinium (MPP+)-induced cell damage in rat adrenal pheochromocytoma PC12 cells. Pretreatment of PC12 cells with SAL significantly reduced the ability of MPP+ to induce apoptosis in a dose and time-dependent manner. SAL significantly and dose-dependently inhibited MPP+-induced chromatin condensation and MPP+-induced release of lactate dehydrogenase by PC12 cells. SAL enhanced Akt phosphorylation in PC12 cells, and the protective effects of SAL against MPP+-induced apoptosis were abolished by LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K) phosphorylation. These findings suggest that SAL prevents MPP+-induced apoptosis in PC12 cells, at least in part through activation of the PI3K/Akt pathway. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.
C1 [Xie, Yonghong] Fourth Mil Med Univ, Tangdu Hosp, Dept Resp, Xian 710038, Peoples R China.
   [Zhang, Lingling; Ding, Wenjun; Li, Xuefen; Chen, Jianzong] Fourth Mil Med Univ, Xijing Hosp, Res Ctr Tradit Chinese Med, Xian 710032, Peoples R China.
   [Huang, JingQun] Fourth Mil Med Univ, Sch Pharm, Dept Nat Med, Xian 710032, Peoples R China.
   [Zhou, Qiong] Fourth Mil Med Univ, Tangdu Hosp, Dept Neurol, Xian 710038, Peoples R China.
   [Sun, Huixing] Guangming Hosp, Dept Surg, Beijing 100061, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Air Force
   Medical University; Air Force Medical University
RP Xie, YH (corresponding author), Fourth Mil Med Univ, Tangdu Hosp, Dept Resp, Xian 710038, Peoples R China.
EM xieyh65@yahoo.com.cn; jzchen57@fmmu.edu.cn
RI ; Zhang, Lingling/OCL-1735-2025
OI Zhang, Lingling/0000-0002-6272-7171; 
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NR 65
TC 52
Z9 58
U1 2
U2 42
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD AUG
PY 2012
VL 50
IS 8
BP 2591
EP 2597
DI 10.1016/j.fct.2012.05.045
PG 7
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA 998QP
UT WOS:000308255800002
PM 22664423
DA 2026-05-27
ER

PT J
AU Zhuang, W
   Yue, LF
   Dang, XF
   Chen, F
   Gong, YW
   Lin, XL
   Luo, YM
AF Zhuang, Wei
   Yue, Lifeng
   Dang, Xiaofang
   Chen, Fei
   Gong, Yuewen
   Lin, Xiaolan
   Luo, Yumin
TI Rosenroot (Rhodiola): Potential Applications in Aging-related
   Diseases
SO AGING AND DISEASE
LA English
DT Review
DE Rhodiola rosea; salidroside; neurodegenerative diseases;
   cardioprotection
ID STANDARDIZED EXTRACT SHR-5; ROSEA L. EXTRACT; OXIDATIVE STRESS;
   ALZHEIMERS-DISEASE; COGNITIVE IMPAIRMENT; SALIDROSIDE PROTECTS;
   CLINICAL-TRIAL; DOUBLE-BLIND; PROLIFERATION; MECHANISMS
AB Aging is a progressive accumulation of changes in the body, which increases the susceptibility to diseases such as Alzheimer's disease, Parkinson's disease, cerebrovascular disease, diabetes, and cardiovascular disease. Recently, Chinese medicinal herbs have been investigated for their therapeutic efficacy in the treatment of some aging-related diseases. Rhodiola, known as 'Hongjingtian' in Chinese, has been reported to have anti-aging activity. Here, we provide a comprehensive review about its origin, chemical constituents, and effects on aging-related diseases.
C1 [Zhuang, Wei; Chen, Fei; Lin, Xiaolan] Capital Med Univ, Xuanwu Hosp, Dept Pharm, Beijing 100053, Peoples R China.
   [Yue, Lifeng] Beijing Univ Chinese Med, Dongzhimen Hosp, Beijing 100700, Peoples R China.
   [Dang, Xiaofang] Hosp TCMS Shijingshan Dist, Dept Pharm, Beijing 100043, Peoples R China.
   [Gong, Yuewen] Univ Manitoba, Coll Pharm, Winnipeg, MB R3E 0T5, Canada.
   [Luo, Yumin] Capital Med Univ, Xuanwu Hosp, Inst Cerebrovasc Dis Res, Beijing 100053, Peoples R China.
   [Luo, Yumin] Capital Med Univ, Xuanwu Hosp, Dept Neurol, Beijing 100053, Peoples R China.
C3 Capital Medical University; Beijing University of Chinese Medicine;
   University of Manitoba; Capital Medical University; Capital Medical
   University
RP Luo, YM (corresponding author), Capital Med Univ, Xuanwu Hosp, Inst Cerebrovasc Dis Res, Beijing 100053, Peoples R China.; Lin, XL (corresponding author), Capital Med Univ, Xuanwu Hosp, Beijing, Peoples R China.
EM xllin83@163.com; yumin111@ccmu.edu.cn
RI Gong, Yuewen/ABA-5742-2020
FU Natural Science Foundation of China [81071058, 81271461]; Fund for
   Beijing Science & Technology Development of TCM [JJ2016-10]; Beijing
   Municipal Science & Technology Commission [Z171100001717006]
FX This work was supported by the Natural Science Foundation of China (Nos.
   81071058, 81271461), the Fund for Beijing Science & Technology
   Development of TCM (No. JJ2016-10) and Beijing Municipal Science &
   Technology Commission (No. Z171100001717006).
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NR 91
TC 70
Z9 79
U1 0
U2 69
PU INT SOC AGING & DISEASE
PI FORT WORTH
PA EDITORIAL OFF, 3400 CAMP BOWIE BLVD, FORT WORTH, TX 76106 USA
SN 2152-5250
J9 AGING DIS
JI Aging Dis.
PD FEB
PY 2019
VL 10
IS 1
BP 134
EP 146
DI 10.14336/AD.2018.0511
PG 13
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA HL2US
UT WOS:000458563800011
PM 30705774
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Dong, T
   Wang, HY
   Li, YW
   Tan, J
AF Dong, Ting
   Wang, Haoyu
   Li, Yanwei
   Tan, Jun
TI Based on the PINK1/Parkin signaling pathway, the protective effect of
   salidroside on cerebral ischemia-reperfusion injury in male rats was
   investigated
SO JOURNAL OF STROKE & CEREBROVASCULAR DISEASES
LA English
DT Article
DE Ferroptosis; GPX4; Mitochondrial Autophagy; Salidroside; Cerebral
   Ischemia-Reperfusion Injury(CIRI)
AB Objective: Based on the male Sprague-Dawley rats middle cerebral artery occlusion model and SH-SY5Y hypoxiareoxygenation model, this study systematically evaluated the neuroprotective effect of salidroside (SAL) on cerebral ischemia/reperfusion injury in rats, and explored its possible protective mechanism through PINK1/ Parkin signaling axis regulating mitochondrial autophagy. Materials and methods: Using the middle cerebral artery occlusion (MCAO) model in male Sprague-Dawley rats and the SH-SY5Y cell hypoxia-reoxygenation model, we assessed neurological damage severity through the modified neurological severity scores (NSS). Brain histopathological changes were evaluated using hematoxylineosin staining, while the infarct volume in the ischemic brain was assessed with 2,3,5-triphenyltetrazolium chloride (TTC) staining. Transmission electron microscopy was employed to observe mitochondrial ultrastructural alterations in the ischemic brain tissue. Western blotting was used for quantitative analysis of key autophagy-related molecules (PINK1, Parkin), and ROS, MDA, and ferrous ion kit were utilized to evaluate ferroptosis biomarker. Results: The findings indicate that SAL effectively reduces infarction rates and ameliorates histopathological changes. SAL decreases the formation of reactive oxygen species, malondialdehyde, and ferrous ions by upregulating the expression of PINK1 and Parkin proteins, thereby mitigating apoptosis. Furthermore, SAL significantly inhibits ferroptosis in SH-SY5Y neuroblastoma cells subjected to OGD/R and reduces oxidative stress. The application of the mitochondrial autophagy inhibitor Mdivi-1 enhances the protective effect of SAL against ferroptosis in both MCAO and OGD/R models. Therefore, we draw the following conclusions: In the rat cerebral ischemia-reperfusion injury model and the SH-SY5Y cell oxygen-glucose deprivation/reoxygenation (OGD/R) model, iron death was found to be increased. Pre-treatment with salidroside was able to reduce the occurrence of iron death in both the cerebral ischemia-reperfusion injury model and the cellular OGD/R model. Conclusions: Salidroside may inhibit iron death by activating the PINK 1 / Parkin signaling pathway and thereby reduce cerebral ischemia-reperfusion injury. Targeted regulation of this pathway may become an important strategy to interfere with CIRI.
C1 [Dong, Ting; Wang, Haoyu; Li, Yanwei; Tan, Jun] Xinxiang Med Coll, Clin Coll 3, Dept Neurol, Med, Xinxiang 453003, Henan, Peoples R China.
   [Tan, Jun] Henan Collaborat Innovat Ctr Prevent & Treatment M, Xinxiang 453002, Henan, Peoples R China.
C3 Henan Medical University
RP Tan, J (corresponding author), Xinxiang Med Coll, Clin Coll 3, Dept Neurol, Med, Xinxiang 453003, Henan, Peoples R China.; Tan, J (corresponding author), Henan Collaborat Innovat Ctr Prevent & Treatment M, Xinxiang 453002, Henan, Peoples R China.
EM 1436439819@qq.com; 1423479194@qq.com; Lyw3621@163.com;
   tanjun1997@126.com
FU Henan Province Medical Science and Technology Research Program Project
   [LHGJ20230546]
FX This study was supported by Henan Province Medical Science and
   Technology Research Program Project (Project Fund No.: LHGJ20230546)
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NR 43
TC 1
Z9 1
U1 0
U2 0
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1052-3057
EI 1532-8511
J9 J STROKE CEREBROVASC
JI J. Stroke Cerebrovasc. Dis.
PD JAN
PY 2026
VL 35
IS 1
AR 108519
DI 10.1016/j.jstrokecerebrovasdis.2025.108519
EA DEC 2025
PG 11
WC Neurosciences; Peripheral Vascular Disease
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Cardiovascular System & Cardiology
GA X7011
UT WOS:001640871100001
PM 41360195
OA gold
DA 2026-05-27
ER

PT J
AU Wang, X
   Ren, YQ
   Du, XY
   Song, LL
   Chan, FS
   Su, F
AF Wang, Xia
   Ren, Yiqing
   Du, Xiaoyuan
   Song, Lili
   Chan, Fushan
   Su, Feng
TI Effects of late-onset dietary intake of salidroside on
   insulin/insulin-like growth factor-1 (IGF-1) signaling pathway of the
   annual fish Nothobranchius guentheri
SO ARCHIVES OF GERONTOLOGY AND GERIATRICS
LA English
DT Article
DE Salidroside; Aging; Lifespan; Annual fish; Nothobranchius
ID AGE-RELATED MARKERS; PEROXIDE-INDUCED INJURY; PROLONGS LIFE-SPAN;
   OXIDATIVE STRESS; CELLS; PROTECTS; SENESCENCE; EXPRESSION; RETARDS
AB Salidroside (SDS) is the main active ingredient of Rhodiola which has many biological functions including antifatigue, anti-tumor, and immune regulation activities. Our last paper demonstrated that SDS prolonged longevity of the annual fish Nothobranchius guentheri, a promising vertebrate model for anti-aging research. However, little is known about its effect on insulin/insulin-like growth factor-1 (IGF-1) signaling pathway (IIS pathway). In this study, we show that SDS is able to decrease accumulation of SA-beta-Gal. We also show that SDS administraton could reduce the expression levels of Igf-1 and Igf-1R, downregulate the expressions of p-PI3K and p-Akt and upregulate the expression levels of Sirtl and Foxo3a, both of which are the downstream regulators of the IIS pathway. We also find that SDS could alleviate DNA damage, which could result in increased expression of transcription factor Foxo3a. Collectively, these data indicate that SDS may take part in the IIS pathway.
C1 [Wang, Xia; Ren, Yiqing; Chan, Fushan] Qingdao Univ Sci & Technol, Shandong Prov Key Lab Biochem Engn, Coll Marine Sci & Biol Engn, 53 Zhengzhou Rd, Qingdao 266042, Shandong, Peoples R China.
   [Su, Feng] Qingdao Univ Sci & Technol, Inst Chem Engn, 53 Zhengzhou Rd, Qingdao 266042, Peoples R China.
   [Du, Xiaoyuan] State Ocean Adm, North China Sea Environm Monitoring Ctr, 22 Fushun Rd, Qingdao 266033, Peoples R China.
   [Song, Lili] Ocean Univ China, Inst Evolut & Marine Biodivers, Dept Marine Biol, Qingdao 266003, Peoples R China.
C3 Qingdao University of Science & Technology; Qingdao University of
   Science & Technology; Ocean University of China
RP Wang, X (corresponding author), Qingdao Univ Sci & Technol, Shandong Prov Key Lab Biochem Engn, Coll Marine Sci & Biol Engn, 53 Zhengzhou Rd, Qingdao 266042, Shandong, Peoples R China.; Su, F (corresponding author), Qingdao Univ Sci & Technol, Inst Chem Engn, 53 Zhengzhou Rd, Qingdao 266042, Peoples R China.
EM wx_fajiao163@163.com; sufengvip@126.com
RI Ren, Yiqing/PDX-8649-2025
FU Natural Science Foundation of China [31801970]; Shandong Provincial Key
   Research and Development Program [2019GHY112040]
FX This work was supported by the Grants of the Natural Science Foundation
   of China (31801970) and Shandong Provincial Key Research and Development
   Program (2019GHY112040).
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NR 37
TC 11
Z9 11
U1 0
U2 21
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0167-4943
EI 1872-6976
J9 ARCH GERONTOL GERIAT
JI Arch. Gerontol. Geriatr.
PD NOV-DEC
PY 2020
VL 91
AR 104233
DI 10.1016/j.archger.2020.104233
PG 6
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA OC9DZ
UT WOS:000579456600042
PM 32858432
DA 2026-05-27
ER

PT J
AU Zou, H
   Hu, D
   Han, T
   Zhao, HY
   Xie, JZ
   Liu, XZ
   Wang, Y
   Gu, JH
   Yuan, Y
   Bian, JC
   Liu, ZP
AF Zou, Hui
   Hu, Di
   Han, Tao
   Zhao, Hongyan
   Xie, Junze
   Liu, Xuezhong
   Wang, Yi
   Gu, Jianhong
   Yuan, Yan
   Bian, Jianchun
   Liu, Zongping
TI Salidroside Ameliorates Cd-Induced Calcium Overload and Gap Junction
   Dysfunction in BRL 3A Rat Liver Cells
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Cadmium; GJIC; Salidroside; Calcium; Cytotoxicity; BRL 3A cells
ID INTERCELLULAR COMMUNICATION; CADMIUM; HOMEOSTASIS; APOPTOSIS; CONNEXIN;
   CHANNELS; STRESS; KIDNEY; TISSUE; DEATH
AB It is known that cadmium (Cd) induces cytotoxicity via Ca2+ signaling, although the underlying mechanism is unclear. Here, we studied the molecular mechanisms of Cd-induced cytotoxicity in BRL 3A cells, a rat liver cell line. We observed that Cd treatment was associated with a time-dependent decrease in cell index (CI) in BRL 3A cells. Mechanistically, we observed that Cd exposure was associated with decreased expression of Cx43, P-Cx43, and Cx32. Specifically, Cx43 was decreased at the site of cell-cell junctions at the cell membrane, corresponding to a decrease in gap junctional intercellular connections (GJICs). We also found that Cd triggered a rise in the intracellular free Ca2+ concentration ([Ca2+](i)), and the intracellular calcium chelator 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid tetrakis, acetoxymethyl ester (BAPTA-AM), prevented the Cd-induced decrease in CI. On the other hand, the gap junction blocker 18-beta-glycyrrhetinic acid (GA) and the endoplasmic reticulum Ca2+-ATPase inhibitor thapsigargin exacerbated cytotoxic injury induced by Cd via further elevating [Ca2+](i), The extracellular calcium chelator ethylene glycol tetraacetic acid could partly attenuate Cd-induced calcium elevation but had little effect on GA combined Cd. Furthermore, salidroside as a protective agent prevented Cd-induced GJIC inhibition and calcium overload. Our findings suggest that Cd triggers elevation of [Ca2+](i) via mainly stimulating Ca2+ release from intracellular Ca2+ storage organelles and inhibiting GJIC, causing cytotoxic injury, and salidroside could be used to prevent Cd-induced cytotoxicity.
C1 [Zou, Hui; Hu, Di; Han, Tao; Zhao, Hongyan; Xie, Junze; Liu, Xuezhong; Wang, Yi; Gu, Jianhong; Yuan, Yan; Bian, Jianchun; Liu, Zongping] Yangzhou Univ, Coll Vet Med, Yangzhou 225009, Jiangsu, Peoples R China.
   [Liu, Zongping] Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou 225009, Jiangsu, Peoples R China.
C3 Yangzhou University; Yangzhou University
RP Liu, ZP (corresponding author), Yangzhou Univ, Coll Vet Med, 88 South Univ Ave, Yangzhou 225009, Jiangsu, Peoples R China.
EM zongpingliu@126.com
RI ; Gu, Jianhong/B-5316-2011
OI YUAN, YAN/0000-0002-1658-5328; 
FU National Natural Science Foundation of China [31101866, 31172373,
   31302058]; Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD)
FX This work was supported by the National Natural Science Foundation of
   China (No. 31101866, No. 31172373, and No. 31302058) and a project
   funded by Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD).
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NR 40
TC 13
Z9 17
U1 0
U2 20
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD MAR
PY 2015
VL 164
IS 1
BP 90
EP 98
DI 10.1007/s12011-014-0201-7
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA CD9SO
UT WOS:000351438800014
PM 25524521
DA 2026-05-27
ER

PT J
AU Wu, YF
   Sun, C
AF Wu, Yufei
   Sun, Chuan
TI Salidroside prevents cadmium chloride-induced DNA damage in human fetal
   lung fibroblasts
SO JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
LA English
DT Article
DE Cadmium; DNA damage; Salidroside; Genotoxicity; Natural extract
ID CHINESE HERBAL MEDICINE; MECHANISMS; SENESCENCE; CELLS; ROS
AB Background: Cadmium (Cd) is an environmental pollutant and a heavy metal known for its genotoxic effects, which can lead to cancer and other related diseases. Preventing Cd-induced genotoxicity is crucial; however, there is limited research on this topic. Salidroside (SAL), a phenylpropanoid glycoside isolated from Rhodiola rosea L., is a popular medicinal compound with several health benefits. Nevertheless, its therapeutic effect on Cd-induced genotoxicity remains unexplored. Methods: Human fetal lung fibroblasts were treated with 20 mu M Cd2+ (CdCl2) for 12 h and 5-20 mu M SAL was used to test the anti-DNA damage effect. DNA damage was evaluated using gamma H2AX expression and the alkaline comet assay. Intracellular reactive oxygen species (ROS) levels were measured using flow cytometry. Results: Exposure to 20 mu M Cd2+ for 12 h induced significant DNA damage in human fetal lung fibroblasts, and this effect was notably attenuated by SAL treatment. SAL treatment did not decrease ROS levels in cells treated with Cd2+. Conclusion: SAL effectively prevented Cd2+-induced DNA damage in human fetal lung fibroblasts. However, the underlying mechanism requires further investigation.
C1 [Wu, Yufei] Anglo Chinese Sch Int, Singapore, Singapore.
   [Sun, Chuan] Zhejiang Hosp, Zhejiang Key Lab Geriatr, Hangzhou 310030, Peoples R China.
   [Sun, Chuan] Zhejiang Hosp, Geriatr Inst Zhejiang Prov, Hangzhou 310030, Peoples R China.
RP Sun, C (corresponding author), 1229 Gudun Rd, Hangzhou, Peoples R China.
EM sun_chuan@aliyun.com
OI Sun, Chuan/0000-0003-3495-5641
FU Medical Science and Technology Project of Zhejiang Province [2021KY005,
   2023KY432]
FX We thank Prof. Genxiang Mao of Zhejiang Hospital for kindly providing
   the SAL and 2BS cell line. This work was supported by the Medical
   Science and Technology Project of Zhejiang Province (2021KY005 and
   2023KY432) .
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NR 49
TC 5
Z9 6
U1 0
U2 4
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0946-672X
EI 1878-3252
J9 J TRACE ELEM MED BIO
JI J. Trace Elem. Med. Biol.
PD DEC
PY 2024
VL 86
AR 127521
DI 10.1016/j.jtemb.2024.127521
EA SEP 2024
PG 6
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA F7V6C
UT WOS:001311852800001
PM 39243731
DA 2026-05-27
ER

PT J
AU Sheng, QS
   Wang, ZJ
   Zhang, J
   Zhang, YG
AF Sheng, Qing-Song
   Wang, Zhi-Jun
   Zhang, Jun
   Zhang, Yong-Guang
TI Salidroside promotes peripheral nerve regeneration following crush
   injury to the sciatic nerve in rats
SO NEUROREPORT
LA English
DT Article
DE nerve crush injury; neuroprotective agent; peripheral nerve
   regeneration; salidroside
ID PROTEIN-KINASE; CELLS; APOPTOSIS; DEATH
AB Salidroside (SDS), a phenylpropanoid glycoside isolated from Rhodiola rosea L., has been reported to be neuroprotective in vitro, which raises the possibility of using SDS as a neuroprotective agent after nerve injuries. In the present study, the possibly beneficial effect of SDS on promoting nerve regeneration after sciatic nerve crush injury in rats was investigated. Rats with sciatic nerve crush injury were administered intraperitoneally daily with 5 or 10mg/kg body weight of SDS for 4 weeks. Rats that received mecobalamin or saline were considered as a positive or a negative control, respectively. Morphometric analysis of regenerated nerves and Fluoro-Gold retrograde tracing was used to evaluate axonal regeneration, whereas walking track analysis, electrophysiological assessment, and histological appearance of target muscles were carried out to evaluate the recovery of motor function. The results showed that SDS achieved functionally successful nerve regeneration in the rat sciatic nerve crush injury model, indicating that SDS holds potential as a neuroprotective agent for peripheral nerve therapies. NeuroReport 24:217-223 (C) 2013 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.
C1 [Sheng, Qing-Song] Fuzhou Gen Hosp, Dept Obstet & Gynecol, Fuzhou 350025, Peoples R China.
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   [Wang, Zhi-Jun] Ningxia Med Univ, Gen Hosp, Dept Radiol, Yinchuan, Peoples R China.
   [Zhang, Jun] Fourth Mil Med Univ, Dept Pharmacol, Xian 710032, Peoples R China.
C3 Ningxia Medical University; Air Force Medical University
RP Zhang, YG (corresponding author), Fuzhou Gen Hosp, Inst Orthopaed, 156 West Ring Rd, Fuzhou 350025, Peoples R China.
EM yg_zhang@163.com
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NR 25
TC 24
Z9 24
U1 0
U2 11
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0959-4965
EI 1473-558X
J9 NEUROREPORT
JI Neuroreport
PD MAR 27
PY 2013
VL 24
IS 5
BP 217
EP 223
DI 10.1097/WNR.0b013e32835eb867
PG 7
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 103VD
UT WOS:000315946700003
PM 23358450
DA 2026-05-27
ER

PT J
AU Lu, LL
   Liu, SS
   Dong, QJ
   Xin, YN
AF Lu, Linlin
   Liu, Shousheng
   Dong, Quanjiang
   Xin, Yongning
TI Salidroside suppresses the metastasis of hepatocellular carcinoma cells
   by inhibiting the activation of the Notch1 signaling pathway
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE salidroside; hepatocellular carcinoma; migration; invasion; Notch1
   signaling pathway
ID HUMAN BREAST-CANCER; RHODIOLA-ROSEA L.; CYCLE ARREST; MATRIX
   METALLOPROTEINASES; PROMOTES METASTASIS; IN-VITRO; INVASION; EXPRESSION;
   MIGRATION; APOPTOSIS
AB Salidroside (SDS) is a phenylpropanoid glycoside isolated from Rhodiola rosea L. It exhibits multiple pharmacological properties in clinical medicine and has been commonly used in traditional Chinese medicine. The present study investigated the inhibitory effects of SDS on tumor invasion and migration, and the expression of metastasis-related genes in highly metastatic hepatocellular carcinoma (HCC) cells (MHCC97H) in vitro. The underlying mechanisms of SDS on the tumor metastasis were also explored. SDS was found to significantly reduce wound closure areas and inhibit cell migration. In addition, SDS markedly inhibited the invasion of these cells into Matrigel-coated membranes. SDS markedly downregulated the expression of Notch1, Snail, COX-2, MMP-2, MMP-9 genes and upregulated the expression of E-cadherin in a dose-dependent manner. Furthermore, SDS inhibited the expression of the Notch signaling target genes, Hey1, Hes1 and Hes5. On the whole, the findings of this study suggest that SDS inhibits HCC cell metastasis by modulating the activity of the Notch1 signaling pathway.
C1 [Lu, Linlin] Qingdao Univ, Qingdao Univ Hosp, Dept Clin Med, Qingdao 266003, Shandong, Peoples R China.
   [Liu, Shousheng; Dong, Quanjiang] Qingdao Municipal Hosp, Cent Labs, Qingdao 266071, Shandong, Peoples R China.
   [Liu, Shousheng; Xin, Yongning] Digest Dis Key Lab Qingdao, Qingdao 266071, Shandong, Peoples R China.
   [Xin, Yongning] Qingdao Municipal Hosp, Dept Gastroenterol, Qingdao 266011, Shandong, Peoples R China.
   [Xin, Yongning] Qingdao Municipal Hosp, Dept Infect Dis, 1 Jiaozhou Rd, Qingdao 266011, Shandong, Peoples R China.
C3 Qingdao University; Qingdao Municipal Hospital; Qingdao Municipal
   Hospital; Qingdao Municipal Hospital
RP Xin, YN (corresponding author), Qingdao Municipal Hosp, Dept Infect Dis, 1 Jiaozhou Rd, Qingdao 266011, Shandong, Peoples R China.
EM xinyongning@163.com
RI dong, quanjiang/AAD-3581-2019
FU Young Scientist Research Foundation of Medjaden Bioscience Limited
   [MJR20160051]; National Natural Science Foundation of China [31770837,
   31800660]
FX The present study was supported by the Young Scientist Research
   Foundation of Medjaden Bioscience Limited (grant no. MJR20160051) and
   the National Natural Science Foundation of China (grant nos. 31770837
   and 31800660).
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NR 60
TC 21
Z9 25
U1 0
U2 17
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JUN
PY 2019
VL 19
IS 6
BP 4964
EP 4972
DI 10.3892/mmr.2019.10115
PG 9
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA II0DC
UT WOS:000474874600048
PM 30942419
OA Bronze
DA 2026-05-27
ER

PT J
AU Qin, Y
   Liu, HJ
   Li, M
   Zhai, DH
   Tang, YH
   Yang, L
   Qiao, KL
   Yang, JH
   Zhong, WL
   Zhang, Q
   Liu, YR
   Yang, G
   Sun, T
   Yang, C
AF Qin, Yuan
   Liu, Hui-juan
   Li, Meng
   Zhai, Deng-hui
   Tang, Yuan-hao
   Yang, Lan
   Qiao, Kai-liang
   Yang, Jia-huan
   Zhong, Wei-long
   Zhang, Qiang
   Liu, Yan-rong
   Yang, Guang
   Sun, Tao
   Yang, Cheng
TI Salidroside improves the hypoxic tumor microenvironment and reverses the
   drug resistance of platinum drugs via HIF-1α signaling pathway
SO EBIOMEDICINE
LA English
DT Article
DE Salidroside; HIF-1 alpha; Hypoxic tumor microenvironment; Drug
   resistance
ID EPITHELIAL-MESENCHYMAL TRANSITION; CANCER; CHEMOTHERAPY
AB Background: Hypoxia commonly occurs in solid tumors. The hypoxia in the center of solid tumors considerably decreases the chemosensitivity of tumor cells and induces epithelial-mesenchymal transition (EMT) as well as drug resistance of antitumor drugs.
   Methods: Here, the effects of salidroside (Sal) combined with platinum drugs on human hepatocellular carcinoma were examined in vitro and in vivo. We investigated the antitumor effects of Sal by inhibiting the drug resistance and explained its mechanism in inhibiting tumor growth.
   Findings: The results showed that Sal co-administration reverses the drug resistance of platinum drugs and suppressed metastasis induced by the hypoxic tumor microenvironment. Sal promoted the degradation of HIF-1 alpha. In conclusion, Sal significantly increased the sensitivity to platinum drugs and inhibited hypoxia-induced EMT in hepatocellular carcinoma (HCC) through inhibiting HIF-1 alpha signaling pathway.
   Interpretation: Therefore, Sal may be an effective platinum drug sensitizer that can improve the chemotherapeutic efficacy in patients with HCC. (c) 2018 The Authors. Published by Elsevier B.V.
C1 [Qin, Yuan; Liu, Hui-juan; Li, Meng; Zhai, Deng-hui; Tang, Yuan-hao; Qiao, Kai-liang; Yang, Jia-huan; Zhong, Wei-long; Zhang, Qiang; Yang, Guang; Sun, Tao; Yang, Cheng] Nankai Univ, State Key Lab Med Chem Biol, Tianjin, Peoples R China.
   [Qin, Yuan; Liu, Hui-juan; Li, Meng; Zhai, Deng-hui; Tang, Yuan-hao; Qiao, Kai-liang; Yang, Jia-huan; Zhong, Wei-long; Zhang, Qiang; Yang, Guang; Sun, Tao; Yang, Cheng] Nankai Univ, Coll Pharm, Tianjin, Peoples R China.
   [Liu, Hui-juan] Nankai Univ, Coll Life Sci, Tianjin, Peoples R China.
   [Qin, Yuan; Li, Meng; Zhai, Deng-hui; Tang, Yuan-hao; Yang, Lan; Qiao, Kai-liang; Yang, Jia-huan; Zhong, Wei-long; Zhang, Qiang; Liu, Yan-rong; Sun, Tao; Yang, Cheng] Tianjin Int Joint Acad Biomed, Tianjin Key Lab Mol Drug Res, Tianjin, Peoples R China.
C3 Nankai University; Nankai University; Nankai University; Tianjin
   International Joint Academy of Biomedicine
RP Yang, G; Sun, T; Yang, C (corresponding author), Nankai Univ, State Key Lab Med Chem Biol, Tianjin, Peoples R China.; Yang, G (corresponding author), Nankai Univ, Coll Pharm, Tianjin, Peoples R China.
EM sunshine@tju.edu.cn; sunrockmia@hotmail.com; cheng.yang@nankai.edu.cn
RI ; wl, z/MBG-3594-2025
OI Qin, Yuan/0000-0002-5651-8293; 
FU Foundation for National Natural Science Funds of China [81703581,
   81572838, 81402973]; National Science and Technology Major Project
   [2018ZX09736005]; Tianjin science and technology innovation system and
   the condition of platform construction plan [14TXSYJC00572]; Post
   doctoral innovative talent support program [BX20180150]
FX This study was founded by Foundation for National Natural Science Funds
   of China (Grant No. 81703581, 81572838, and 81402973), National Science
   and Technology Major Project (Grant No. 2018ZX09736005), Tianjin science
   and technology innovation system and the condition of platform
   construction plan (Grant No. 14TXSYJC00572), Post doctoral innovative
   talent support program(Grant No. BX20180150). None of these funding
   sources had any role in writing the manuscript nor the decision to
   submit for publication. The authors attest they have not been paid
   towrite this article by a pharmaceutical company or other agency.
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NR 37
TC 56
Z9 62
U1 3
U2 48
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 2352-3964
J9 EBIOMEDICINE
JI EBioMedicine
PD DEC
PY 2018
VL 38
BP 25
EP 36
DI 10.1016/j.ebiom.2018.10.069
PG 12
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA HF2FN
UT WOS:000454052500013
PM 30396856
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, ZY
   Li, L
   Li, WL
   Yan, HY
   Yuan, Y
AF Wang, Ziyue
   Li, Lu
   Li, Wenliang
   Yan, Haiyang
   Yuan, Yuan
TI Salidroside Alleviates Furan-Induced Impaired Gut Barrier and
   Inflammation via Gut Microbiota-SCFA-TLR4 Signaling
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE gut microbiota; short-chain fatty acids (SCFAs); salidroside (SAL);
   furan; fecal microbiota transplantation(FMT); antibiotic cocktail (ABX)
ID CHAIN FATTY-ACIDS; SUPPLEMENTATION; DISRUPTION
AB As a food contaminant that can be quickly absorbed through the gastrointestinal system, furan has been shown to disrupt the intestinal flora and barrier. Investigation of the intestinal toxicity mechanism of furan is of great significance to health. We previously identified the regulatory impact of salidroside (SAL) against furan-provoked intestinal damage, and the present work further explored whether the alleviating effect of SAL against furan-caused intestinal injury was based on the intestinal flora; three models, normal, pseudo-germ-free, and fecal microbiota transplantation (FMT), were established, and the changes in intestinal morphology, barrier, and inflammation were observed. Moreover, 16S rDNA sequencing observed the variation of the fecal flora associated with inflammation and short-chain fatty acids (SCFAs). Results obtained from the LC-MS/MS suggested that SAL increased furan-inhibited SCFA levels, activated the mRNA expressions of SCFA receptors (GPR41, GPR43, and GPR109A), and inhibited the furan-activated TLR4/MyD88/NF-kappa B signaling. Analysis of protein-protein interaction further confirmed the aforementioned effects of SAL, which inhibited furan-induced barrier damage and intestinal inflammation.
C1 [Wang, Ziyue; Li, Lu; Li, Wenliang; Yan, Haiyang; Yuan, Yuan] Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Peoples R China.
C3 Jilin University
RP Yan, HY; Yuan, Y (corresponding author), Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Peoples R China.
EM yanhyjlu@163.com; yuan_yuan@jlu.edu.cn
RI Li, Wenliang/F-2907-2014
FU National Natural Science Foundation of China [31972181]; Graduate
   Innovation Fund of Jilin University [2023CX137]
FX The authors received supporting funds from the National Natural Science
   Foundation of China (no. 31972181) and Graduate Innovation Fund of Jilin
   University (no. 2023CX137).
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NR 52
TC 16
Z9 18
U1 2
U2 55
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD JUL 11
PY 2024
VL 72
IS 29
BP 16484
EP 16495
DI 10.1021/acs.jafc.4c02433
EA JUL 2024
PG 12
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA ZM0K8
UT WOS:001266691800001
PM 38990698
DA 2026-05-27
ER

PT J
AU Lu, LL
   Yuan, JS
   Zhang, SC
AF Lu, Linlin
   Yuan, Jiangshui
   Zhang, Shicui
TI Rejuvenating activity of salidroside (SDS): dietary intake of SDS
   enhances the immune response of aged rats
SO AGE
LA English
DT Article
DE Rats; Salidroside; Ageing; Anti-ageing; Immune response
ID DELAYED-HYPERSENSITIVITY; RHODIOLA-ROSEA; INJURY; CELLS; YOUNG;
   SUPPLEMENTATION; MORTALITY; SYSTEM
AB It is well known that immune response decreases with aging. Salidroside (SDS), an antioxidant component isolated from the traditional Chinese medicine roseroot Rhodiola rosea, has been demonstrated to possess potent anti-aging and health-promoting activities. However, the mechanism underlying these activities is poorly understood. In this study, we clearly demonstrated that (1) dietary intake of SDS induced a considerable increase in total T cells (CD3(+)) and T helper cells (CD4(+)) in aged (21 months old) Wistar male rats; (2) SDS supplementation significantly increased the DTH response, a T cell-mediated immune response, in aged rats; and (3) SDS supplementation remarkably promoted the production of total anti-KLH IgG, anti-KLH IgG(1), and anti-KLH IgG(2 alpha) in aged rats without disturbing immune homeostasis. These indicate that SDS is able to counteract immunosenescence, thereby resulting in rejuvenation. Practically, SDS may be used to help the elderly to generate an improved response to vaccine with stronger humoral and cell-mediated immune responses.
C1 [Lu, Linlin; Yuan, Jiangshui; Zhang, Shicui] Ocean Univ China, Inst Evolut & Marine Biodivers, Lab Evolut & Dev, Qingdao 266003, Peoples R China.
   [Yuan, Jiangshui] Qingdao Municipal Hosp, Clin Lab, Qingdao 266071, Peoples R China.
C3 Ocean University of China; Qingdao Municipal Hospital
RP Zhang, SC (corresponding author), Ocean Univ China, Inst Evolut & Marine Biodivers, Lab Evolut & Dev, Room 205,5 Yushan Rd, Qingdao 266003, Peoples R China.
EM sczhang@ouc.edu.cn
FU Ministry of Science and Technology (MOST) of China [2012CB114404]
FX The authors thank Ms. Jie Ma and Mr. Hongmiao Wang for their aids in
   collection of the blood and tissues of the animals. The authors also
   thank Dr. Gamal El-Sokkary for his valuable comments and suggestions on
   this paper. This work was supported in part by a grant (2012CB114404) of
   Ministry of Science and Technology (MOST) of China.
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NR 40
TC 27
Z9 36
U1 0
U2 27
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0161-9152
EI 1574-4647
J9 AGE
JI Age
PD JUN
PY 2013
VL 35
IS 3
BP 637
EP 646
DI 10.1007/s11357-012-9394-x
PG 10
WC Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology
GA 133XL
UT WOS:000318174100010
PM 22367581
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU Zhang, YF
   Zhou, ZL
   Zou, L
   Chi, R
AF Zhang, Yuefei
   Zhou, Zhangli
   Zou, Lian
   Chi, Ruan
TI Imidazolium-based ionic liquids with inorganic anions in the extraction
   of salidroside and tyrosol from Rhodiola: The role of cations and
   anions on the extraction mechanism
SO JOURNAL OF MOLECULAR LIQUIDS
LA English
DT Article
DE Ionic liquid; Rhodiola; Salidroside; Tyrosol; Electrostatic potential
   analysis
ID MICROWAVE-ASSISTED EXTRACTION; ABSOLUTE-CONFIGURATIONS; CELLULOSE;
   MICROEXTRACTION; OPTIMIZATION; SPECTROSCOPY; FLAVONOIDS; SEPARATION; IR
AB The role of cations and anions of imidazolium ionic liquid-based microwave-assisted extraction system for salidroside and tyrosol of Rhodiola was investigated. To evaluate eight kinds of imidazolium-based ionic liquid with different cations and anions on molecule level, the geometries of related IL molecules and target extracts were optimized by density functional theory at the B3LYP/6-311++G(d, p) level. Electrostatic potential (ESP) distributions of these molecules above are identified in the water modeled by the polarizable continuum model. The theoretical and experimental analysis shows there is some correlation between the characteristic values of ESP distribution and extraction yield. The more similar the ESP distribution of ILs are to salidroside and tyrosol, the higher the extraction yields are. Wider variability of ESP is beneficial to extraction. The main role of cations is interaction with extract molecules by its positive ESP regions. So the cations influence the solubility of extracts by the molecular interaction. Unlike the cations, the types of anions can affect the structure of the cell wall. The ILs with Br anion have greater ability to dissolve cellulose and break the cell wall, which made the target components within the cell could effectively dissolve. Due to the differing function of cations and anions of ILs, the ionic liquid-based MAE could provide higher extraction yields and take much shorter extraction time than conventional organic solvents. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Zhang, Yuefei; Zhou, Zhangli] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Hubei, Peoples R China.
   [Zou, Lian] Wuhan Univ, Sch Elect Informat, Wuhan 430072, Hubei, Peoples R China.
   [Chi, Ruan] Wuhan Inst Technol, Minist Educ, Key Lab Green Chem Proc, Wuhan 430073, Hubei, Peoples R China.
C3 Wuhan Institute of Technology; Wuhan University; Wuhan Institute of
   Technology
RP Zhang, YF (corresponding author), Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430205, Hubei, Peoples R China.
EM zyfwit@126.com; zoulian@whu.edu.cn
RI zhou, zhangli/LKM-6258-2024
FU National Natural Science Foundation of China [21006075]
FX This work was supported by the National Natural Science Foundation of
   China (grant number 21006075).
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NR 44
TC 28
Z9 32
U1 1
U2 43
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0167-7322
EI 1873-3166
J9 J MOL LIQ
JI J. Mol. Liq.
PD FEB 1
PY 2019
VL 275
BP 136
EP 145
DI 10.1016/j.molliq.2018.11.009
PG 10
WC Chemistry, Physical; Physics, Atomic, Molecular & Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Physics
GA HK8GW
UT WOS:000458228400015
DA 2026-05-27
ER

PT J
AU Liu, J
   Li, DZ
   Dun, YS
   Li, H
   Ripley-Gonzalez, JW
   Zhang, J
   Qiu, L
   You, BY
   Liu, SX
AF Liu, Jie
   Li, Dezhao
   Dun, Yaoshan
   Li, Hui
   Ripley-Gonzalez, Jeffrey W.
   Zhang, Jie
   Qiu, Ling
   You, Baiyang
   Liu, Suixin
TI Rhodiola activates macrophage migration inhibitory factor to
   alleviate non-alcoholic fatty liver disease
SO LIFE SCIENCES
LA English
DT Article
DE Rhodiola; Salidroside; Macrophage migration inhibitory factor;
   Nonalcoholic fatty liver disease; Lipophagy; Lipid metabolism
ID INVOLVEMENT; AUTOPHAGY; MIF
AB Aims: Rhodiola was found to be a potential treatment for nonalcoholic fatty liver disease (NAFLD). The macrophage migration inhibitory factor (MIF)-regulated lipophagy and lipid metabolism might be the therapeutic targets of Rhodiola.
   Main methods: A 16-week high-fat diet (HFD) was used to simulate a NAFLD mouse model. Rhodiola extract or normal saline were administrated to mice. Blood was collected to assess blood glucose and insulin, and livers were harvested to assess lipid accumulation and metabolism. In cell experiments, the active ingredient of Rhodiola, salidroside, and recombinant MIF protein (rMIF) were used to treat palmitate (PA)-incubated HepG2 cells, with MIF-siRNA or NC-siRNA transfection. Then, the level of lipophagy and lipid metabolism was examined.
   Key findings: Rhodiola improved lipid accumulation and metabolism disorder of HFD mice. The oil red O staining of the liver showed that increased lipid droplets in the NAFLD liver could be relieved by Rhodiola; Rhodiola also alleviated the increasing body weight, liver weight, and HOMA-IR index of HFD mice. Results in cell experiments were consistent: salidroside relieved the lipid droplet accumulation and triglyceride release in PA cells, as well as reduced lipophagosome and lipid metabolism disorder in PA cells. However, all these effects of salidroside were partially blocked by MIF-siRNA transfection.
   Significance: Rhodiola reduces lipid accumulation in the liver of NAFLD by facilitating the MIF pathway and the downstream lipophagy and lipid metabolism. MIF may be an endogenous regulator of liver lipophagy and lipid metabolism and a potential therapeutic target for NAFLD.
C1 [Liu, Jie] Hunan Tradit Chinese Med Coll, Sch Med, Dept Internal Med, Zhuzhou, Hunan, Peoples R China.
   [Li, Dezhao; Dun, Yaoshan; Ripley-Gonzalez, Jeffrey W.; Zhang, Jie; Qiu, Ling; You, Baiyang; Liu, Suixin] Cent South Univ, Dept Phys Med & Rehabil, Div Cardiac Rehabil, Xiangya Hosp, Changsha, Hunan, Peoples R China.
   [Dun, Yaoshan; Li, Hui; Qiu, Ling; You, Baiyang; Liu, Suixin] Cent South Univ, Natl Clin Res Ctr Geriatr Disorders, Xiangya Hosp, Changsha, Hunan, Peoples R China.
   [Li, Hui] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Rehabil Ctr, Jinan, Shandong, Peoples R China.
C3 Hunan University of Chinese Medicine; Central South University; Central
   South University; Shandong University
RP You, BY; Liu, SX (corresponding author), Hosp Cent South Univ, 87 Xiangya Rd, Changsha, Hunan, Peoples R China.
EM youbaiyang@csu.edu.cn; liusuixin@csu.edu.cn
RI Dun, Yaoshan/GOH-2956-2022; Li, Dezhao/HHZ-2165-2022; Ripley-Gonzalez,
   Jeffrey/JED-5494-2023
OI Dun, Yaoshan/0000-0001-8642-9024; 
FU National Natural Science Foundation of China [82172549, 82102672,
   82002403]; Natural Science Foundation of Hunan Province [2021JJ60072,
   2021JJ70073]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Grant number: 82172549 to SL, 82102672 to BY,
   82002403 to YD), and Natural Science Foundation of Hunan Province (Grant
   number: 2021JJ60072 to JL, 2021JJ70073 to SL).
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NR 32
TC 13
Z9 15
U1 1
U2 38
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 1
PY 2022
VL 308
AR 120949
DI 10.1016/j.lfs.2022.120949
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 7T9PB
UT WOS:000911770600004
PM 36096243
OA hybrid
DA 2026-05-27
ER

PT J
AU Huang, MQ
   Tang, ML
   Liu, L
AF Huang, Manqian
   Tang, Meiling
   Liu, Lu
TI Salidroside Attenuates Epilepsy and Cognitive Dysfunction in Rats by
   Downregulating Complement C3-C3aR Pathway-Mediated Activation of
   Microglia and Astrocytes
SO NEUROCHEMICAL RESEARCH
LA English
DT Article
DE Salidroside; Epilepsy; Cognitive dysfunction; Complement C3-C3aR
   pathway; Microglia; Astrocytes; Neuroinflammation
ID MODEL; EXPRESSION; CELLS
AB Epilepsy is a chronic neurological disorder featured by abnormal neural discharges that can lead to cognitive impairment. Salidroside (Sal), a biologically active component, protects neurons against various insults. The current study aims to explore the therapeutic potential of Sal in epilepsy and elucidate the mechanisms underlying its effects. We established a rat model of status epilepticus (SE) using pentylenetetrazol-kindling. SE rats were treated with Sal. Assessment of seizure latency and epileptic stage scores were performed. Cognitive function of rats was evaluated using a novel object recognition test and a Morris water maze test. Neuronal damage and hippocampal pathology were examined, alongside microglial and astrocyte activation, complement C3-C3a receptor (C3-C3aR) pathway involvement, and inflammatory factor levels. Sal prolonged seizure latency, decreased epilepsy stage scores, and improved cognitive performance compared to untreated SE rats. Furthermore, Sal suppressed the activation of C3-C3ar, microglia, and astrocytes, while decreasing the levels of inflammatory factors, which ameliorated hippocampal damage and neuronal loss. Sal may attenuate epilepsy and cognitive dysfunction by downregulating complement C3-C3aR pathway-mediated activation of microglia and astrocytes.
C1 [Huang, Manqian; Tang, Meiling] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Pediat, Hengyang 421002, Hunan, Peoples R China.
   [Liu, Lu] Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Gastrointestinal Surg, Hengyang 421002, Hunan, Peoples R China.
C3 University of South China; University of South China
RP Liu, L (corresponding author), Univ South China, Affiliated Nanhua Hosp, Hengyang Med Sch, Dept Gastrointestinal Surg, Hengyang 421002, Hunan, Peoples R China.
EM 18397419507@163.com
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NR 39
TC 1
Z9 1
U1 3
U2 5
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD AUG 21
PY 2025
VL 50
IS 5
AR 271
DI 10.1007/s11064-025-04514-8
PG 12
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 7TC6K
UT WOS:001579025600002
PM 40839226
DA 2026-05-27
ER

PT J
AU Li, JN
   Wang, RB
   Chen, Q
   Tian, YQ
   Gao, LL
   Lei, AM
AF Li, Jiannan
   Wang, Ruibin
   Chen, Qiang
   Tian, Yiqi
   Gao, Leilei
   Lei, Anmin
TI Salidroside improves porcine oocyte maturation and subsequent embryonic
   development by promoting lipid metabolism
SO THERIOGENOLOGY
LA English
DT Article
DE Salidroside; Lipid metabolism; Mitochondria; Embryo development
ID GENE-EXPRESSION; ACID; SUPPLEMENTATION; MITOPHAGY; CELLS
AB An optimal lipid droplet (LD) content is essential for successful mammalian embryonic development. Salidroside (SAL) is a traditional Chinese medicine and one of the important active components of the Rhodiola plant. SAL possesses antioxidative, anti-aging, and cardiovascular properties. Here, we studied the effects of SAL on in vitro maturation (IVM) of porcine oocytes and the subsequent embryonic development after parthenogenetic activation (PA). We found that 100 mu M of SAL had no effect on the extrusion rate of the first polar body of porcine oocytes but significantly improved the subsequent blastocyst formation rate and embryo quality. Our study further revealed that SAL treatment altered the morphology, increased the lipid content in oocytes, increased mitochondrial number. Further analysis revealed that SAL upregulated the expression of genes related to lipid metabolism (FASN, FADS1, HSL, and CPT1a) and the mitochondria function-related genes (PGC-1 alpha). These results suggest that SAL supplementation enhances oocyte maturation and subsequent embryonic development by promoting lipid metabolism, providing the necessary energy for the aforementioned processes. (c) 2022 Elsevier Inc. All rights reserved.
C1 [Li, Jiannan; Wang, Ruibin; Chen, Qiang; Tian, Yiqi; Gao, Leilei; Lei, Anmin] Northwest A&F Univ, Coll Vet Med, Shaanxi Stem Cell Engn & Technol Res Ctr, Yangling 712100, Shaanxi, Peoples R China.
C3 Northwest A&F University - China
RP Lei, AM (corresponding author), Northwest A&F Univ, Coll Vet Med, Shaanxi Stem Cell Engn & Technol Res Ctr, Yangling 712100, Shaanxi, Peoples R China.
EM lijiannan@nwafu.edu.cn; fatimah@nwafu.edu.cn;
   chenqiang2017@nwafu.edu.cn; tianyiqi@nwafu.edu.cn;
   gaoleilei@nwafu.edu.cn; anminleiryan@nwsuaf.edu.cn
RI LEI, An-min/B-6234-2011; Gao, Leilei/KVB-4091-2024
OI LEI, An-min/0000-0002-5066-8709; 
FU Ministry of Agriculture of the People's Republic of China
   [2016ZX08006003]
FX This work was supported by the Ministry of Agriculture of the People's
   Republic of China (2016ZX08006003). We would like to thank MogoEdit
   (https://www.mogoedit.com) for its English editing during the
   preparation of this manuscript.
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NR 51
TC 19
Z9 20
U1 0
U2 17
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0093-691X
EI 1879-3231
J9 THERIOGENOLOGY
JI Theriogenology
PD OCT 15
PY 2022
VL 192
BP 89
EP 96
DI 10.1016/j.theriogenology.2022.08.028
PG 8
WC Reproductive Biology; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology; Veterinary Sciences
GA 6M3HT
UT WOS:000888763400004
PM 36084388
DA 2026-05-27
ER

PT J
AU Bocharova, OA
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   Poroikov, VV
   Bocharov, E
   Karpova, R
   Ionov, NS
   Kucheryanu, VG
   Kosorukov, VS
   Matveev, VB
   Stilidi, IS
AF Bocharova, O. A.
   Kazeev, I., V
   Shevchenko, V. E.
   Sheichenko, O. P.
   Poroikov, V. V.
   Bocharov, E., V
   Karpova, R., V
   Ionov, N. S.
   Kucheryanu, V. G.
   Kosorukov, V. S.
   Matveev, V. B.
   Stilidi, I. S.
TI A POTENTIAL METHOD FOR STANDARDIZATION OF MULTIPHYTOADAPTOGEN: TANDEM
   MASS SPECTROMETRY FOR ANALYSIS OF BIOLOGICALLY ACTIVE SUBSTANCES FROM
   Rhodiola rosea
SO PHARMACEUTICAL CHEMISTRY JOURNAL
LA English
DT Article
DE Rhodiola rosea L.; HPLC-MS/MS; phytoadaptogens; salidroside; rosavin;
   rosarin; rosiridin; rhodionin; antitumor activity; in silico evaluation
ID PHYTOADAPTOGEN; SALIDROSIDE; EXPRESSION; CELLS; L.
AB Tandem mass spectrometry (HPLC-MS/MS) was used to analyze biologically active compounds in extracts of the tuber and roots of Rhodiola rosea (family Crassulaceae) and in the pharmaceutical formulation Multiphytoadaptogen (MPA). Chromatography was run on Acquity UPLC BEH C18 columns with gradient elution. A TSQ Vantage ternary quadrupole mass spectrometer with electrospray ionization was used. MPA, like the Rhodiola rosea tuber/root extract, was found to contain salidroside, rosavin. rosarin, rosiridin, and rhodionin. These results can be used for standardization, identification, and quality control of phytocomplexes containing these Rhodiola rosea compounds to identify grounds for the mechanisms of the biological actions of MPA and studying its novel properties, taking account of the components identified. The PASS computer program was used for in silico evaluation of the spectra of the antitumor activities of these compounds. Antitumor effects were predicted with high probability for all five phytocomponents; the specific characteristic of the actions of individual compounds suggested that combinations might be used for treating a wide spectrum of malignant neoplasms.
C1 [Bocharova, O. A.; Kazeev, I., V; Shevchenko, V. E.; Bocharov, E., V; Karpova, R., V; Kosorukov, V. S.; Matveev, V. B.; Stilidi, I. S.] Minist Hlth Russian Federat, NN Blokhina Natl Oncol Med Res Ctr, 24 Kashirskoe Chausee, Moscow 115478, Russia.
   [Sheichenko, O. P.] All Russian Sci Res Inst Med & Aromat Plants VILA, Bldg 1,7 Grin St, Moscow 117216, Russia.
   [Poroikov, V. V.; Ionov, N. S.] VN Orekhovich Sci Res Inst Biomed Chem, Bldg,8,10 Pogodinskaya St, Moscow 119121, Russia.
   [Kucheryanu, V. G.] Sci Res Inst Gen Pathol & Pathophysiol, 8 Baltiiskaya St, Moscow 125315, Russia.
C3 Ministry of Health of the Russian Federation; Russian Academy of Medical
   Sciences; Institute of Biomedical Chemistry; Russian Academy of Medical
   Sciences; Institute of General Pathology & Pathophysiology, RAMS
RP Bocharova, OA (corresponding author), Minist Hlth Russian Federat, NN Blokhina Natl Oncol Med Res Ctr, 24 Kashirskoe Chausee, Moscow 115478, Russia.
EM imufarm@rambler.ru
RI Matveev, Vsevolod/O-7476-2017; Kosorukov, Viacheslav/A-3901-2014;
   /AAB-1722-2020; Bocharov, Eduard/LMQ-3548-2024; Poroikov,
   Vladimir/O-2769-2013; Ionov, Nikita/AAH-5992-2019
OI Ionov, Nikita/0000-0001-5396-2789
FU Commission for Biomedical Innovations and Technologies, Russian
   Federation Ministry of Science; Basic Long-Term Scientific Research
   Program of the Russian Federation [2021 -2030]
FX This study was partially funded by grants from the Commission for
   Biomedical Innovations and Technologies, Russian Federation Ministry of
   Science, and the Basic Long-Term Scientific Research Program of the
   Russian Federation (2021 -2030).
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NR 40
TC 3
Z9 5
U1 0
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0091-150X
EI 1573-9031
J9 PHARM CHEM J+
JI Pharm. Chem. J.
PD APR
PY 2022
VL 56
IS 1
BP 78
EP 84
DI 10.1007/s11094-022-02607-0
EA APR 2022
PG 7
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 0N3TX
UT WOS:000781177800001
DA 2026-05-27
ER

PT J
AU He, H
   Chang, XY
   Gao, J
   Zhu, LP
   Miao, MX
   Yan, TH
AF He, He
   Chang, Xiayun
   Gao, Jin
   Zhu, Lingpeng
   Miao, Mingxing
   Yan, Tianhua
TI Salidroside Mitigates Sepsis-Induced Myocarditis in Rats by Regulating
   IGF-1/PI3K/Akt/GSK-3β Signaling
SO INFLAMMATION
LA English
DT Article
DE salidroside; sepsis; myocardial inflammation; IGF-I/PI3K/Akt/GSK-3 beta
   signaling
ID GROWTH-FACTOR-I; OXIDATIVE STRESS; INJURY; ANGIOGENESIS; HYPERTROPHY;
   APOPTOSIS; PATHWAY; MICE
AB Sepsis-induced myocardial injury (SIMI) is caused by various mechanisms. The aim of this study was to investigate the effects of salidroside (Sal) on SIMI and its mechanisms in rats. The sepsis model was established by intraperitoneal injection of lipopolysaccharide (LPS) (15 mg/kg in sterile saline). Sal decreased the serum levels of creatine kinase (CK), lactate dehydrogenase (LDH), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta), whereas the expressions of insulin-like growth factor-1 (IGF-1) signaling-related proteins, such as IGF-1 and its corresponding receptor (IGF-1R), phosphatidylinositol 3-kinase (PI3K), p-PI3K, Akt, p-Akt, and glycogen synthase kinase-3 beta (GSK-3 beta), in the heart were decreased with Sal pretreatment. Mitigated myocardial cell swelling, degeneration, loss of transverse striations, and inflammatory cell infiltration were also observed in the LPS + Sal groups. Thus, Sal is assumed to exert pronounced cardioprotective effects in rats subjected to LPS, probably through regulation of IGF-1/PI3K/Akt/GSK-3 beta signaling.
C1 [He, He; Chang, Xiayun; Gao, Jin; Zhu, Lingpeng; Miao, Mingxing; Yan, Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Jiangsu, Peoples R China.
C3 China Pharmaceutical University
RP Miao, MX (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Tongjiaxiang 24, Nanjing, Jiangsu, Peoples R China.
EM miaomingxingcpu@126.com; yantianhuabest@126.com
RI he, he/JPL-3505-2023; Su, Tianyuan/Y-7054-2019
FU National Twelve Five Major Drug Discovery Project [2011ZX09102-002-01]
FX This work was supported by the National Twelve Five Major Drug Discovery
   Project (2011ZX09102-002-01).
CR [Anonymous], PLOS ONE
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NR 26
TC 61
Z9 69
U1 0
U2 27
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD DEC
PY 2015
VL 38
IS 6
BP 2178
EP 2184
DI 10.1007/s10753-015-0200-7
PG 7
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA CV4GA
UT WOS:000364223800018
PM 26104971
DA 2026-05-27
ER

PT J
AU Chu, YH
   Chen, CJ
   Wu, SH
   Hsieh, JF
AF Chu, Yung-Hung
   Chen, Chao-Jung
   Wu, Shih-Hsiung
   Hsieh, Jung-Feng
TI Inhibition of Xanthine Oxidase by Rhodiola crenulata Extracts and
   Their Phytochemicals
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE xanthine oxidase; inhibitor; hyperuricemia; Rhodiola crenulata
ID SALIDROSIDE; CONSTITUENTS; CONSTANTS; TYROSOL; MODEL; TWIGS; MICE; ROOT
AB Using a fractionation technique, four phytochemicals were isolated from Rhodiola crenulata extracts. These compounds were identified as 4'-hydroxyacetophenone (4-HAP), epicatechin-(4 beta,8)-epicatechin gallate (B2-3'-O-gallate), salidroside, and p-tyrosol using mass spectrometry and nuclear magnetic resonance spectroscopy. The inhibition of xanthine oxidase (XO) activity by these purified compounds was then evaluated and compared to that of a known XO inhibitor (allopurinol; IC50 = 12.21 +/- 0.27 mu M). Both 4-HAP and B2-3'-O-gallate showed an XO inhibitory effect, for which the half maximal inhibitory concentration (IC50) values were 15.62 +/- 1.19 and 24.24 +/- 1.80 mu M, respectively. However, salidroside and p-tyrosol did not show significant inhibitory effects on XO at 30 mu M. Furthermore, an inhibition kinetics study indicated that 4-HAP and B2-3'-O-gallate are mixed competitive inhibitors. The inhibition constants (K-i) of 4-HAP and B2-3'-O-gallate were 8.41 +/- 1.03 and 6.16 +/- 1.56 mu M, respectively. These results suggest that 4-HAP and B2-3'-O-gallate are potent XO inhibitors.
C1 [Chu, Yung-Hung; Chen, Chao-Jung; Hsieh, Jung-Feng] Fu Jen Catholic Univ, Dept Food Sci, Taipei 24205, Taiwan.
   [Wu, Shih-Hsiung] Acad Sinica, Inst Biol Chem, Taipei 11529, Taiwan.
C3 Fu Jen Catholic University; Academia Sinica - Taiwan
RP Hsieh, JF (corresponding author), Fu Jen Catholic Univ, Dept Food Sci, 510 Zhongzheng Rd, Taipei 24205, Taiwan.
EM 075101@mail.fju.edu.tw
RI Chen, ChaoJung/NRB-7017-2025
OI Chen, Chao Jung/0009-0009-0516-6521
FU National Science Council [NSC 99-2313-B-030-001-MY3]
FX The authors thank the National Science Council (NSC
   99-2313-B-030-001-MY3) for financial support.
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NR 30
TC 51
Z9 54
U1 3
U2 98
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD APR 30
PY 2014
VL 62
IS 17
BP 3742
EP 3749
DI 10.1021/jf5004094
PG 8
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA AG4DI
UT WOS:000335369100012
PM 24712453
DA 2026-05-27
ER

PT J
AU Zhang, X
   Huang, L
   Feng, WJ
   Xu, DH
   Zeng, YR
AF Zhang, Xu
   Huang, Ling
   Feng, Wenjun
   Xu, Danghan
   Zeng, Yirong
TI Salidroside ameliorates lipopolysaccharide-induced ferroptosis in
   chondrocytes via regulation of the sirt1/foxo1 axis
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE salidroside; osteoarthritis; sirt1/foxo1 signaling; ferroptosis
ID OSTEOARTHRITIS; OSTEOPOROSIS; CARTILAGE; CANCER
AB Salidroside (SAL) is a bioactive constituent extracted from Rhodiola rosea plant and exerts antioxidant and anti-inflammatory properties. However, understanding of SAL for the treatment of arthritis is limited. The aim of the present study was to investigate whether SAL treats lipopolysaccharide (LPS)-induced chondrocyte injury by modulating the sirt1 silent information regulator 1)/FoxO1 (forkhead transcription factors O1) signaling pathway. Network pharmacology was used to screen the potential pathway of SAL for the treatment of osteoarthritis via the ferroptosis pathway. Subsequently, a chondrocyte inflammation model was established in vitro using LPS and SAL was used as a drug treatment. Effects of SAL treatment of chondrocytes was evaluated by western blot analysis, fluorescence, cell viability and oxidative assay. Analysis revealed that SAL significantly attenuated LPS-induced apoptosis and accumulation of oxides in chondrocytes, thereby protecting the integrity of cartilage extracellular matrix. In addition, SAL promoted the activation of the sirt1/foxo1 signaling cascade, which alleviated LPS-induced ferroptosis in chondrocytes. The present study demonstrated that SAL attenuated LPS-induced chondrocyte ferroptosis by regulating the sirt1/foxo1 pathway. This may provide a potential therapeutic avenue for cartilage damage in osteoarthritis.
C1 [Zhang, Xu] Guangzhou Univ Chinese Med, Sch Clin Med 1, Guangzhou 510405, Guangdong, Peoples R China.
   [Zhang, Xu] Guangzhou Univ Chinese Med, Dept Orthoped, Shunde Hosp, Leliu Hosp, Guangzhou 528000, Guangdong, Peoples R China.
   [Huang, Ling] Shunde Third Peoples Hosp, Dept Orthoped, Guangzhou 528000, Guangdong, Peoples R China.
   [Feng, Wenjun; Xu, Danghan; Zeng, Yirong] Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Orthopaed, 16 Jichang Rd, Guangzhou 510405, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Southern Medical University -
   China; Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine
RP Zeng, YR (corresponding author), Guangzhou Univ Chinese Med, Affiliated Hosp 1, Dept Orthopaed, 16 Jichang Rd, Guangzhou 510405, Guangdong, Peoples R China.
EM z39298@sohu.com
RI Xu, Danghan/P-1067-2018
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NR 52
TC 7
Z9 7
U1 1
U2 6
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD MAY
PY 2025
VL 31
IS 5
AR 138
DI 10.3892/mmr.2025.13502
PG 12
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 0WT3L
UT WOS:001457857800001
PM 40145553
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhang, XQ
   Zhang, MD
   Zhang, ZY
   Zhou, SB
AF Zhang, Xianqi
   Zhang, Mengdi
   Zhang, Ziyan
   Zhou, Shengbo
TI Salidroside induces mitochondrial dysfunction and ferroptosis to inhibit
   melanoma progression through reactive oxygen species production
SO EXPERIMENTAL CELL RESEARCH
LA English
DT Article
DE Malignant melanoma; Salidroside; Reactive oxygen species; Ferroptosis;
   Mitochondrial dysfunction; Seahorse XF96 flux analyzer
ID CELLS; APOPTOSIS; DISEASE
AB Reactive oxygen species (ROS) induces necroptotic and ferroptosis in melanoma cells. Salidroside (SAL) regulates ROS in normal cells and inhibits melanoma cell proliferation. This study used human malignant melanoma cells treated with SAL either alone or in combination with ROS scavenger (NAC) or ferroptosis inducer (Erastin). Through cell viability, wound healing assays, and a Seahorse analyze found that SAL inhibited cell proliferation, migration, extracellular acidification rate, and oxygen consumption rate. Metabolic flux analysis, complexes I, II, III, and IV activity of the mitochondrial respiratory chain assays, mitochondrial membrane potential assay, mitochondrial ROS, and transmission electron microscope revealed that SAL induced mitochondrial dysfunction and ultrastructural damage. Assessment of malondialdehyde, lipid ROS, iron content measurement, and Western blot analysis showed that SAL activated lipid peroxidation and promoted ferroptosis in A-375 cells. These effects were abolished after NAC treatment. Additionally, SAL and Erastin both inhibited cell proliferation and promoted cell death; SAL increased the Erastin sensitivity of cells while NAC antagonized it. In xenograft mice, SAL inhibited melanoma growth and promoted ROS -dependent ferroptosis. SAL induced mitochondrial dysfunction and ferroptosis to block melanoma progression through ROS production, which offers a scientific foundation for conducting SAL pharmacological research in the management of melanoma.
C1 [Zhang, Xianqi] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Dermatol, Hangzhou 310009, Zhejiang, Peoples R China.
   [Zhang, Mengdi] Xi An Jiao Tong Univ, Dept Dermatol, Affiliated Hosp 2, Xian 710003, Shaanxi, Peoples R China.
   [Zhang, Ziyan] Shanxi Med Univ, Dept Radiol, Hosp 1, Taiyuan 030001, Shanxi, Peoples R China.
   [Zhou, Shengbo] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Plast & Reconstruct Surg, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
C3 Zhejiang University; Xi'an Jiaotong University; Shanxi Medical
   University; Shanghai Jiao Tong University
RP Zhou, SB (corresponding author), Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Sch Med, Dept Plast & Reconstruct Surg, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
EM xianqizhang@zju.edu.cn; xianqizhang@zju.edu.cn; xianqizhang@zju.edu.cn;
   zhou.shengbo@163.com
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NR 53
TC 16
Z9 18
U1 0
U2 21
PU ELSEVIER INC
PI SAN DIEGO
PA 525 B STREET, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4827
EI 1090-2422
J9 EXP CELL RES
JI Exp. Cell Res.
PD MAY 1
PY 2024
VL 438
IS 1
AR 114034
DI 10.1016/j.yexcr.2024.114034
EA APR 2024
PG 13
WC Oncology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Cell Biology
GA RR4F8
UT WOS:001229369000001
PM 38588875
DA 2026-05-27
ER

PT J
AU Zhang, B
   Li, QQ
   Chu, XK
   Sun, SY
   Chen, SD
AF Zhang, Bei
   Li, Qiongqiong
   Chu, Xingkun
   Sun, Suya
   Chen, Shengdi
TI Salidroside reduces tau hyperphosphorylation via up-regulating GSK-3β
   phosphorylation in a tau transgenic Drosophila model of
   Alzheimer's disease
SO TRANSLATIONAL NEURODEGENERATION
LA English
DT Article
DE Alzheimer's disease; Salidroside; Drosophila; Glycogen synthase kinase 3
   beta; Tau
ID PEROXIDE-INDUCED INJURY; PROTEIN-TAU; TOXICITY; NEURODEGENERATION;
   TRANSPORT; COMPONENT; MEDICINE; PROGRESS; NEURONS; OCCURS
AB Background: Alzheimer's disease (AD) is an age-related and progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe treatment against AD. Salidroside (Sal) is the main effective component of Rhodiola rosea L., which has several pharmacological activities. The objective of this study was to investigate the efficacy of Sal in the treatment of AD transgenic Drosophila and the associated mechanisms.
   Methods: We used tau transgenic Drosophila line (TAU) in which tau protein is expressed in the central nervous system and eyes by the Gal4/UAS system. After feeding flies with Sal, the lifespan and locomotor activity were recorded. We further examined the appearance of vacuoles in the mushroom body using immunohistochemistry, and detected the levels of total glycogen synthase kinase 3 beta (t-GSK-3 beta), phosphorylated GSK-3 beta (p-GSK-3 beta), t-tau and p-tau in the brain by western blot analysis.
   Results: Our results showed that the longevity was improved in salidroside-fed Drosophila groups as well as the locomotor activity. We also observed less vacuoles in the mushroom body, upregulated level of p-GSK-3 beta and downregulated p-tau following Sal treatment.
   Conclusion: Our data presented the evidence that Sal was capable of reducing the neurodegeneration in tau transgenic Drosophila and inhibiting neuronal loss. The neuroprotective effects of Sal were associated with its up-regulation of the p-GSK-3 beta and down-regulation of the p-tau.
C1 [Zhang, Bei; Li, Qiongqiong; Sun, Suya; Chen, Shengdi] Shanghai Jiao Tong Univ, Sch Med, Dept Neurol, 197 Ruijin Er Rd, Shanghai 200025, Peoples R China.
   [Zhang, Bei; Li, Qiongqiong; Sun, Suya; Chen, Shengdi] Shanghai Jiao Tong Univ, Sch Med, Inst Neurol, Ruijin Hosp, 197 Ruijin Er Rd, Shanghai 200025, Peoples R China.
   [Zhang, Bei; Chu, Xingkun; Chen, Shengdi] Chinese Acad Sci, SIBS, Inst Hlth Sci, Lab Neurodegenerat Dis, Shanghai 200025, Peoples R China.
   [Zhang, Bei; Chu, Xingkun; Chen, Shengdi] SJTUSM, Shanghai 200025, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Chinese
   Academy of Sciences; Shanghai Jiao Tong University
RP Sun, SY; Chen, SD (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Dept Neurol, 197 Ruijin Er Rd, Shanghai 200025, Peoples R China.; Sun, SY; Chen, SD (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Inst Neurol, Ruijin Hosp, 197 Ruijin Er Rd, Shanghai 200025, Peoples R China.
EM sunsuya@shsmu.edu.cn; chen_sd@medmail.com.cn
FU National Natural Science Fund [91332107, 81430022, 81371407]
FX This work was supported by grants from the National Natural Science Fund
   (91332107, 81430022, 81371407). All founding were used for the design,
   collection, analysis and interpretation of data and in writing in the
   manuscript.
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NR 41
TC 41
Z9 49
U1 1
U2 39
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 2047-9158
J9 TRANSL NEURODEGENER
JI Transl. Neurodegener.
PD NOV 29
PY 2016
VL 5
AR 21
DI 10.1186/s40035-016-0068-y
PG 6
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EE1ZO
UT WOS:000389383200001
PM 27933142
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, JH
   Zhang, L
   Duan, W
   Jiang, TC
   Ruan, C
   Kasim, V
   Wu, SR
AF Wang, Jiahao
   Zhang, Lei
   Duan, Wei
   Jiang, Tianchi
   Ruan, Cao
   Kasim, Vivi
   Wu, Shourong
TI Salidroside analogue C-30 promotes neovascularization in diabetic
   hindlimb ischemic mice by inducing macrophage M2 polarization
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE diabetic hindlimb ischemia; revascularization; macrophage;
   salidroside-derivated analogue
ID PERIPHERAL ARTERIAL-DISEASE; CRITICAL LIMB ISCHEMIA; THERAPEUTIC
   ANGIOGENESIS; REGENERATION; INFLAMMATION; ACTIVATION; EXPRESSION; CELLS
AB Hindlimb ischemia (HLI) is a disease caused by the obstruction of blood vessels, and is a major complication of diabetes. Therapeutic angiogenesis, which aims to promote angiogenesis and blood perfusion recovery, is a potential therapeutic strategy for HLI. However, hyperglycemia systematically impairs intrinsic angiogenesis potential, including macrophage polarization from M1 to M2, thereby impeding efficient therapeutic angiogenesis. Salidroside-derived glycoside analogue C-30 (C20H24O7), which was synthesized in our previous study, has markedly enhanced the therapeutic angiogenesis potential in diabetic HLI mice; however, the underlying molecular mechanism remains unknown, and whether it could induce macrophage M2 polarization under hyperglycemia remains unclear. Herein, we revealed that C-30 could significantly promote macrophage M2 polarization under hyperglycemia. Through transcriptomic analysis and validation at cellular level, we revealed that C-30 could suppress hyperglycemia-induced NF-kappa B signaling pathway activation in macrophages, thereby enhancing oxidative phosphorylation, and eventually, M2 polarization. This in turn facilitates macrophage-blood vessel-forming cells crosstalk and augments angiogenic potential under hyperglycemia. Importantly, intramuscular administration of the NF-kappa B activator CU-T12-9 abolished C-30-mediated upregulation of macrophage polarization and homeostasis, and eventually, angiogenesis in diabetic HLI mice. Together, these findings clearly show that C-30 could enhance neovascularization and functional blood vessel formation by inducing macrophage M2 polarization in diabetic hindlimb ischemia mice. This study highlights the potential of intramuscularly injected salidroside-derived glycoside analogue in treating diabetic HLI by targeting macrophage M2 polarization.
C1 [Wang, Jiahao; Zhang, Lei; Duan, Wei; Jiang, Tianchi; Ruan, Cao; Kasim, Vivi; Wu, Shourong] Chongqing Univ, Coll Bioengn, Key Lab Biorheol Sci & Technol, Minist Educ, Chongqing 400044, Peoples R China.
   [Wang, Jiahao; Zhang, Lei; Duan, Wei; Jiang, Tianchi; Ruan, Cao; Kasim, Vivi; Wu, Shourong] Chongqing Univ, Coll Bioengn, Project Lab Biomech & Tissue Repair 111, Chongqing 400044, Peoples R China.
   [Kasim, Vivi; Wu, Shourong] Chongqing Univ, Coll Bioengn, State & Local Joint Engn Lab Vasc Implants, Chongqing 400044, Peoples R China.
C3 Chongqing University; Chongqing University; Chongqing University
RP Kasim, V; Wu, SR (corresponding author), Chongqing Univ, Coll Bioengn, Chongqing, Peoples R China.
EM vivikasim@cqu.edu.cn; shourongwu@cqu.edu.cn
RI Kasim, Vivi/AID-0964-2022
OI Kasim, Vivi/0000-0001-9182-8230
FU Natural Science Foun-dation of Chongqing [CSTB2022NSCQ-MSX0611,
   CSTB2022NSCQ-MSX0612]
FX This work was supported by grants from the Natural Science Foun-dation
   of Chongqing (CSTB2022NSCQ-MSX0611 (SW) and CSTB2022NSCQ-MSX0612 (V.K.)
   ) .
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NR 59
TC 0
Z9 0
U1 3
U2 4
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD DEC 22
PY 2025
VL 167
AR 115708
DI 10.1016/j.intimp.2025.115708
EA OCT 2025
PG 17
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA 9ES0O
UT WOS:001604574100004
PM 41130092
OA hybrid
DA 2026-05-27
ER

PT J
AU Niu, L
   Xu, M
   Liu, WQ
   Yu, HD
   Yu, SX
   Li, FZ
   Wang, T
   Sun, D
   Yao, TF
   Li, WZ
   Yang, ZZ
   Liu, XZ
   Zuo, ZF
AF Niu, Lin
   Xu, Min
   Liu, Wenqiang
   Yu, Hongdan
   Yu, Shengxue
   Li, Fuzhi
   Wang, Teng
   Sun, Die
   Yao, Tiefeng
   Li, Wanze
   Yang, Zhengzhong
   Liu, Xuezheng
   Zuo, Zhongfu
TI The GLCCI1/STAT3 pathway: a novel pathway involved in diabetic cognitive
   dysfunction and the therapeutic effect of salidroside
SO JOURNAL OF MOLECULAR HISTOLOGY
LA English
DT Article
DE Glucocorticoid-induced transcript 1; Diabetic cognitive dysfunction;
   Apoptosis; Salidroside
ID TRANSCRIPT 1 GENE; DEFICIENCY; APOPTOSIS
AB Diabetic cognitive dysfunction (DCD) is a complication of diabetes that seriously affects quality of life. Glucocorticoid-induced transcript 1 (GLCCI1) has been found to be involved in inflammation, apoptosis and autophagy in various diseases. However, the distribution of GLCCI1 in the brain and its role in DCD have not yet been revealed. In addition, the potential therapeutics effects of salidroside (SAL), a phenyl propyl glycoside compound known for its neuroprotective effects in treating DCD are unknow. In the present study, we found that GLCCI1 was localized in hippocampal neurons. C57BL/6 J mice with DCD presented downregulation of GLCCI1 and Bcl-2 and upregulation of p-STAT3/STAT3, Bax, Cleaved Caspase-3/Caspase-3. Overexpression of GLCCI1 or SAL administration relieved DCD, reversed the changes in the expression of these cytokines, and alleviated morphological alterations in hippocampal neurons. Interestingly, SAL alleviated DCD and attenuated the expression of GLCCI1 and p-STAT3, showing similar effects as GLCCI1 overexpression. These findings suggest that the GLCCI1/STAT3 axis plays a crucial role in DCD and is involved in SAL-mediated attenuation of DCD.
C1 [Niu, Lin; Liu, Wenqiang; Yu, Hongdan; Yu, Shengxue; Sun, Die; Yao, Tiefeng; Li, Wanze; Yang, Zhengzhong; Liu, Xuezheng; Zuo, Zhongfu] Jinzhou Med Univ, Dept Anat Histol & Embryol, Jinzhou 121001, Liaoning, Peoples R China.
   [Xu, Min; Liu, Wenqiang; Liu, Xuezheng; Zuo, Zhongfu] Liaoning Key Lab Diabetic Cognit & Percept Dysfunc, Jinzhou 121001, Liaoning, Peoples R China.
   [Xu, Min] Liaoning Vocat Univ Technol, Coll Nursing Physiol, Jinzhou 121001, Liaoning, Peoples R China.
   [Li, Fuzhi] Jinzhou Med Univ, Dept Thoraxes Surg Affiliated Hosp 3, Jinzhou 121001, Liaoning, Peoples R China.
   [Wang, Teng] Jinzhou Med Univ, Affiliated Hosp 1, Jinzhou 121000, Liaoning, Peoples R China.
C3 Jinzhou Medical University; Jinzhou Medical University; Jinzhou Medical
   University
RP Liu, XZ; Zuo, ZF (corresponding author), Jinzhou Med Univ, Dept Anat Histol & Embryol, Jinzhou 121001, Liaoning, Peoples R China.; Liu, XZ; Zuo, ZF (corresponding author), Liaoning Key Lab Diabetic Cognit & Percept Dysfunc, Jinzhou 121001, Liaoning, Peoples R China.
EM 1227426403@qq.com; 1213890901@qq.com; 1084720193@qq.com;
   yuhongdan1116@126.com; ysx1019@163.com; lifuzhi@163.com;
   919848359@qq.com; 2658618671@qq.com; 2023294135@qq.com;
   2746617361@qq.com; 354392879@qq.com; liuxuezheng@jzmu.edu.cn;
   zuozhongfu@jzmu.edu.cn
RI li, fuzhi/JFK-4525-2023; yao, tiefeng/PII-7022-2026
FU Foundation of Education Department of Liaoning Province
FX No Statement Available
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NR 41
TC 2
Z9 4
U1 0
U2 4
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1567-2379
EI 1567-2387
J9 J MOL HISTOL
JI J. Mol. Histol.
PD OCT
PY 2024
VL 55
IS 5
BP 851
EP 861
DI 10.1007/s10735-024-10236-y
EA AUG 2024
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA I3X2D
UT WOS:001299694300001
PM 39198367
DA 2026-05-27
ER

PT J
AU Coenye, T
   Brackman, G
   Rigole, P
   De Witte, E
   Honraet, K
   Rossel, B
   Nelis, HJ
AF Coenye, Tom
   Brackman, Gilles
   Rigole, Petra
   De Witte, Evy
   Honraet, Kris
   Rossel, Bart
   Nelis, Hans J.
TI Eradication of Propionibacterium acnes biofilms by plant extracts
   and putative identification of icariin, resveratrol and salidroside as
   active compounds
SO PHYTOMEDICINE
LA English
DT Article
DE Propionibacterium acnes; Biofilm; Salidroside; Icariin; Resveratrol;
   Epimedium brevicornum; Polygonum cuspidatum
ID IN-VITRO; INHIBITION; RESISTANCE
AB Propionibacterium acnes is a Gram-positive bacterium that plays an important role in the pathogenesis of acne vulgaris. This organism is capable of biofilm formation and the decreased antimicrobial susceptibility of biofilm-associated cells may hamper efficient treatment. In addition, the prolonged use of systemic antibiotic therapy is likely to lead to the development and spread of antimicrobial resistance. In the present study we investigated whether P. acnes biofilms could be eradicated by plant extracts or their active compounds, and whether other mechanisms besides killing of biofilm cells could be involved. Out of 119 plant extracts investigated, we identified five with potent antibiofilm activity against P. acnes (extracts from Epimedium brevicornum, Malus pumila, Polygonum cuspidatum, Rhodiola crenulata and Dolichos lablab). We subsequently identified icariin, resveratrol and salidroside as active compounds in three of these extracts. Extracts from E. brevicornum and P. cuspidatum, as well as their active compounds (icariin and resveratrol, respectively) showed marked antibiofilm activity when used in subinhibitory concentrations, indicating that killing of microbial cells is not their only mode of action. (C) 2011 Elsevier GmbH. All rights reserved.
C1 [Coenye, Tom; Brackman, Gilles; Rigole, Petra; De Witte, Evy; Nelis, Hans J.] Univ Ghent, Lab Pharmaceut Microbiol, B-9000 Ghent, Belgium.
   [Honraet, Kris; Rossel, Bart] Oystershell NV, Drongen, Belgium.
C3 Ghent University
RP Coenye, T (corresponding author), Univ Ghent, Lab Pharmaceut Microbiol, Harelbekestr 72, B-9000 Ghent, Belgium.
EM Tom.Coenye@UGent.be
RI ; Coenye, Tom/A-6291-2014
OI Brackman, Gilles/0000-0001-7037-7717; Coenye, Tom/0000-0002-6407-0601
FU Oystershell NV; IWT-Vlaanderen
FX We acknowledge Oystershell NV for the use of their collection of Chinese
   plant extracts. Financial support was received from Oystershell NV and
   from IWT-Vlaanderen.
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NR 14
TC 88
Z9 99
U1 1
U2 55
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD MAR 15
PY 2012
VL 19
IS 5
BP 409
EP 412
DI 10.1016/j.phymed.2011.10.005
PG 4
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 929BK
UT WOS:000303036000005
PM 22305279
DA 2026-05-27
ER

PT J
AU Zhu, X
   Hai, Z
   Ning, ZP
AF Zhu, Xi
   Hai, Zhen
   Ning, Zhongping
TI Salidroside impedes Ang II-infused myocardial fibrosis by activating the
   SIRT1-Nrf2 pathway
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Angiotensin II; SIRT1; Oxidative stress; Reactive oxygen species;
   Salidroside
ID REDOX BIOLOGY; CELL-DEATH; INFLAMMATION; INHIBITION; STRESS; INJURY
AB Objective(s): This research examined the protective function of salidroside (SAL) against angiotensin II (Ang II)-infused myocardial fibrosis and its associated mechanism. Materials and Methods: The C57BL/6 male murine models (n=24) received either saline solution or Ang II (1500 ng/kg/day) subcutaneously and an oral dosage of SAL (50 mg/kg/day) once daily for 28 days. Newborn Sprague-Dawley (SD) rats were used to isolate atrial fibroblasts. Results: The fibrotic region was raised by Ang II infusion, while SAL treatment inhibited it. Collagen I and III expression was raised by Ang II induction, but SAL therapy reduced their expression. SAL therapy also decreased the expression of other fibroblast differentiation-related markers induced by Ang II infusion. It elevated SIRT1, Nrf2, and HO-1 levels in atrial fibroblasts. Additionally, SAL significantly inhibited atrial fibroblasts, whereas EX527, an inhibitor of SIRT1, noticeably increased the migration ability. Furthermore, SAL suppressed intracellular ROS production and oxidative stress in Ang II-infused atrial fibroblasts. Conclusion: SAL protects against myocardial fibrosis infused by Ang II by activating the SIRT1-Nrf2 pathway.
C1 [Zhu, Xi; Hai, Zhen; Ning, Zhongping] Zhoupu Hosp, Dept Cardiol, Shanghai Pudong New Area, Shanghai Hlth Med Coll, 1500 Zhou Yuan Rd, Shanghai 201318, Peoples R China.
RP Ning, ZP (corresponding author), Zhoupu Hosp, Dept Cardiol, Shanghai Pudong New Area, Shanghai Hlth Med Coll, 1500 Zhou Yuan Rd, Shanghai 201318, Peoples R China.
EM ningzpsh@163.com
FU Pudong New Area Health Committee discipline leader training program
   [PWRd2021-17]; Key Discipline Group of Pudong New Area Health Commission
   [PWZxq2022-11]; Key Discipline of Shanghai Health System [2024ZDXK0019]
FX This study was supported by 1. The Pudong New Area Health Committee
   discipline leader training program (PWRd2021-17) ; 2. Key Discipline
   Group of Pudong New Area Health Commission (No.PWZxq2022-11) ; 3. Key
   Discipline of Shanghai Health System (2024ZDXK0019) .
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NR 47
TC 1
Z9 1
U1 1
U2 6
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD JUN
PY 2025
VL 28
IS 6
BP 815
EP 824
DI 10.22038/ijbms.2025.83659.18105
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 0FW2E
UT WOS:001446383700015
PM 40343296
DA 2026-05-27
ER

PT J
AU Sun, SM
   Hu, HL
   Li, FY
   Huan, S
   Chen, L
   Chen, JH
   Sun, PH
   Dong, XQ
AF Sun, Sumin
   Hu, Haili
   Li, Feiyu
   Huan, Sheng
   Chen, Long
   Chen, Jiahui
   Sun, Peihua
   Dong, Xiaoqing
TI Salidroside enhances 5-fluorouracil sensitivity against hepatocellular
   carcinoma via YIPF5-induced mitophagy
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; 5-fluorouracil; mitophagy; senescence; mitosis;
   hepatocellular carcinoma
ID CANCER; MITOCHONDRIA; MECHANISMS
AB Hepatocellular carcinoma (HCC) is a major medical challenge due to its high incidence and poor prognosis. 5-Fluorouracil (5-FU), although extensively studied in the treatment of HCC and other solid tumors, has limited application as a first-line therapy for HCC due to its resistance and significant inter-patient variability. To address these issues, researchers have explored drug repurposing. One of our key findings in this endeavour was the potent anti-HCC effect of the natural product Salidroside (Sal) when co-administered with 5-FU. Sal was found to inhibit mitosis and promote cellular senescence in HCC cells via a mechanism distinct from 5-FU, specifically by inducing excessive mitophagy that led to cellular mitochondrial dysfunction. Importantly, YIPF5 was confirmed as a potential molecular target of Sal. This natural product modulated YIPF5-induced mitophagy and influenced both mitosis and senescence in HCC cells. The combination of Sal and 5-FU demonstrated significant therapeutic effects in a mouse HCC model. In conclusion, our study was not only in line with the innovative strategy of drug repurposing, but also important for drug design and natural product screening targeting the relevant pathways.
C1 [Sun, Sumin; Hu, Haili; Li, Feiyu; Huan, Sheng; Chen, Long; Chen, Jiahui; Sun, Peihua; Dong, Xiaoqing] Nanjing Normal Univ, Joint Inst Nanjing Drum Tower Hosp Life & Hlth, Coll Life Sci, Nanjing, Peoples R China.
   [Li, Feiyu; Dong, Xiaoqing] Nanjing Univ Chinese Med, Dept Hematol, Nanjing Drum Tower Hosp, Clin Coll, Nanjing, Peoples R China.
C3 Nanjing Normal University; Nanjing University of Chinese Medicine;
   Nanjing University
RP Dong, XQ (corresponding author), Nanjing Normal Univ, Joint Inst Nanjing Drum Tower Hosp Life & Hlth, Coll Life Sci, Nanjing, Peoples R China.; Dong, XQ (corresponding author), Nanjing Univ Chinese Med, Dept Hematol, Nanjing Drum Tower Hosp, Clin Coll, Nanjing, Peoples R China.
EM qgswns@126.com
RI Chen, Jiahui/OZF-8457-2025
FU National Natural Science Foundation of China [82304987]; Postgraduate
   Research & Practice Innovation Program of Jiangsu Province [KYCX23_1737]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   financially supported by the National Natural Science Foundation of
   China (82304987) and the Postgraduate Research & Practice Innovation
   Program of Jiangsu Province (KYCX23_1737).
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NR 45
TC 4
Z9 5
U1 5
U2 11
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JAN 6
PY 2025
VL 15
AR 1503490
DI 10.3389/fphar.2024.1503490
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA S6L2N
UT WOS:001399307100001
PM 39834805
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liao, WT
   Liu, J
   Wang, SM
   Xue, Z
   Zheng, F
   Feng, F
   Liu, WY
AF Liao, Wenting
   Liu, Jia
   Wang, Shiming
   Xue, Zhen
   Zheng, Feng
   Feng, Feng
   Liu, Wenyuan
TI Metabolic profiling reveals that salidroside antagonizes hypoxic injury
   via modulating energy and lipid metabolism in cardiomyocytes
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Metabolomics; UPLC-QTOFMS; Salidroside; Hypoxic injury; Drug targets
ID PATHWAY; CELLS; ACCUMULATION; ISCHEMIA; NAD(+)
AB Hypoxia induces cardiomyocytes injury, which further triggers the occurrence and development of cardiovascular diseases. There is a paucity of specific treatment options available with proven efficacy. Chinese patented pharmaceutical product Salidroside (Sal) has potent efficacy on treating hypoxic injury. However, the molecular mechanism remains obscure. In the present study, a UPLC-QTOFMS-based metabolomic method combined with cell viability and apoptosis assays were established to explore the therapeutic mechanisms of Sal against hypoxic injury. Significant protective effects of Sal against inhibited cell viability and apoptosis induced by hypoxic injury were observed in the pharmacodynamic evaluation. Moreover, 40 significantly changed metabolites related to hypoxic injury were identified, of which, 26 can be significantly regulated by Sal. Metabolic pathway enrichment analysis revealed that the mechanisms of Sal against hypoxic injury may be attributed to modulating the disordered homeostasis of energy and lipid metabolism. The present study provides new experimental information on the pathogenesis of hypoxia, unravels the potential targeted metabolic pathways of Sal against hypoxia on the whole metabolic network and highlights the importance of metabolomics as a potential tool for deciphering drug-targeted metabolic pathways.
C1 [Liao, Wenting; Wang, Shiming; Xue, Zhen; Zheng, Feng; Liu, Wenyuan] China Pharmaceut Univ, Dept Pharmaceut Anal, Nanjing 210009, Peoples R China.
   [Feng, Feng] Taian City Cent Hosp, Joint Lab Chinese Pharmaceut Univ & Taian City Ce, Tai An 271000, Peoples R China.
   [Liu, Wenyuan] China Pharmaceut Univ, Hangzhou Inst Pharmaceut Innovat, 291 Fucheng Lu, Hangzhou 310018, Zhejiang, Peoples R China.
   [Feng, Feng] Jiangsu Food & Pharmaceut Sci Coll, Huaian 223003, Peoples R China.
   [Liu, Jia] China Pharmaceut Univ, Anim Ctr, Pharm Lab, Nanjing 210009, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University;
   Jiangsu Food & Pharmaceutical Science College; China Pharmaceutical
   University
RP Liu, WY (corresponding author), China Pharmaceut Univ, Dept Pharmaceut Anal, Nanjing 210009, Peoples R China.
EM liuwenyuan8506@163.com
FU National Natural Science Foundation of China [81301685, 81573557]
FX This work was funded by the National Natural Science Foundation of China
   (No. 81301685, 81573557).
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NR 31
TC 14
Z9 19
U1 0
U2 42
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD FEB
PY 2020
VL 122
AR 109700
DI 10.1016/j.biopha.2019.109700
PG 9
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA KA7VF
UT WOS:000506005800030
PM 31918273
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xing, SS
   Yang, J
   Li, WJ
   Li, J
   Chen, L
   Yang, YT
   Lei, X
   Li, J
   Wang, K
   Liu, X
AF Xing, Sha-Sha
   Yang, Jin
   Li, Wen-jing
   Li, Jian
   Chen, Lin
   Yang, Yu-ting
   Lei, Xia
   Li, Jun
   Wang, Kai
   Liu, Xun
TI Salidroside Decreases Atherosclerosis Plaque Formation via
   Inhibiting Endothelial Cell Pyroptosis
SO INFLAMMATION
LA English
DT Article
DE salidroside; pyroptosis; GSDMD; atherosclerosis; endothelial cells
ID NLRP3 INFLAMMASOME; GASDERMIN D; APOPTOSIS; CASPASES; TARGET; DEATH
AB Pyroptosis, a new pro-inflammatory programmed cell death, is linked to atherosclerosis (AS). Our previous studies suggested that salidroside (SAL) can alleviate AS and exert anti-oxidative and anti-inflammatory properties. However, the effect of SAL on atherosclerosis-related pyroptosis has not been studied. Here, we investigated the effect of SAL on pyroptosis to explain the underlying mechanisms of SAL on atherosclerosis-related inflammation. We established an atherosclerosis mouse model via western diet (HFD) to explore the protective effect of SAL. According to our results, administration of SAL for 12 weeks markedly reduced the atherosclerotic plaque in aorta. Meanwhile, SAL also alleviated the pyroptosis, as evidenced by inhibiting caspase-1 activation, interleukin-1 beta (IL-1 beta) release, and TUNEL-positive staining, and decreasing the expression of Gasdermin D (GSDMD). Furthermore, SAL also decreased the activation of caspase-1 and inhibited the release of IL-1 beta induced by lipopolysaccharide (LPS) and adenosine triphosphate (ATP) in human umbilical vein endothelial cell (HUVECs). Our data indicate that SAL inhibit NLRP3-related pyroptosis, which might be the underlying mechanism of SAL anti-inflammatory in atherosclerosis.
C1 [Xing, Sha-Sha; Yang, Yu-ting; Lei, Xia] Chengdu Univ, Clin Drug Trial Inst, Affiliated Hosp, Chengdu 610081, Sichuan, Peoples R China.
   [Yang, Jin; Chen, Lin; Wang, Kai; Liu, Xun] Chengdu Univ, Dept Urol, Affiliated Hosp, Chengdu 610081, Sichuan, Peoples R China.
   [Li, Wen-jing] Wuhan Univ, Dept Pharm, Zhongnan Hosp, Wuhan 430071, Peoples R China.
   [Li, Jian] Chengdu Univ, Dept Basic Med, Sch Med, Chengdu 610106, Sichuan, Peoples R China.
   [Li, Jun] Chengdu Univ, Affiliated Hosp, Dept Gen Surg, Chengdu 610081, Sichuan, Peoples R China.
C3 Chengdu University; Chengdu University; Wuhan University; Chengdu
   University; Chengdu University
RP Yang, J (corresponding author), Chengdu Univ, Dept Urol, Affiliated Hosp, Chengdu 610081, Sichuan, Peoples R China.
EM yangjincdfy@126.com
RI xing, shasha/JFB-2393-2023; Li, Junshan/K-7564-2019
FU Sichuan Science and Technology Program [2019 YJ0654]; Technology Bureau
   of Chengdu [2015-HM01-00434-SF, 2015-HM01-00580-SF]
FX This work was supported by Sichuan Science and Technology Program [2019
   YJ0654] and The Technology Bureau of Chengdu [2015-HM01-00434-SF,
   2015-HM01-00580-SF].
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NR 27
TC 58
Z9 66
U1 2
U2 36
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD APR
PY 2020
VL 43
IS 2
BP 433
EP 440
DI 10.1007/s10753-019-01106-x
EA FEB 2020
PG 8
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA LF3YK
UT WOS:000516249600002
PM 32076940
DA 2026-05-27
ER

PT J
AU Chen, B
   Zhang, LY
   Chen, G
AF Chen, Bo
   Zhang, Luyan
   Chen, Gang
TI Determination of salidroside and tyrosol in Rhodiola by capillary
   electrophoresis with graphene/poly(urea-formaldehyde) composite modified
   electrode
SO ELECTROPHORESIS
LA English
DT Article
DE Amperometric detection; Capillary electrophoresis; Graphene;
   Poly(urea-formaldehyde); Rhodiola
ID PHARMACOLOGICALLY ACTIVE COMPOUNDS; FILLED UREA-FORMALDEHYDE; PRODUCT
   DRUG DISCOVERY; DIRECT ELECTROCHEMISTRY; GRAPHENE; RESINS; OXIDE
AB This report describes the fabrication and application of a novel graphene/poly(urea-formaldehyde) composite modified electrode as a sensitive amperometric detector of CE. The composite electrode was fabricated on the basis of the in situ polycondensation of a mixture of graphenes and urea-formaldehyde prepolymers on the surface of a platinum disc electrode. It was coupled with CE for the separation and detection of salidroside and tyrosol in Rhodiola, a traditional Chinese medicine, to demonstrate its feasibility and performance. Salidroside and tyrosol have been well separated within 6 min in a 40 cm long capillary at a separation voltage of 12 kV using a 50 mM borate buffer (pH 9.8). The prepared graphene-based CE detector offered significantly lower detection potential, yielded enhanced signal-to-noise characteristics, and exhibited high resistance to surface fouling and enhanced stability. It showed long-term stability and reproducibility with relative standard deviations of less than 5% for the peak current (n = 15).
C1 [Chen, Bo; Zhang, Luyan; Chen, Gang] Fudan Univ, Sch Pharm, Shanghai 200032, Peoples R China.
C3 Fudan University
RP Chen, G (corresponding author), Fudan Univ, Sch Pharm, 138 Yixueyuan Rd, Shanghai 200032, Peoples R China.
EM gangchen@fudan.edu.cn
RI bo, chen/M-1290-2019
FU NSFC [20875015, 21075020]; Shanghai Science Committee [2009JC1401400];
   Ministry of Science and Technology [2006BAI19B02, 2007AA04Z309,
   2009ZX09301-011]; Education Ministry of China [NCET-08-0134]
FX This work was financially supported by NSFC (20875015 and 21075020),
   Shanghai Science Committee (2009JC1401400), the Ministry of Science and
   Technology (2006BAI19B02, 2007AA04Z309, and 2009ZX09301-011), and the
   Education Ministry of China (NCET-08-0134).
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NR 31
TC 36
Z9 41
U1 0
U2 68
PU WILEY-BLACKWELL
PI MALDEN
PA COMMERCE PLACE, 350 MAIN ST, MALDEN 02148, MA USA
SN 0173-0835
J9 ELECTROPHORESIS
JI Electrophoresis
PD APR
PY 2011
VL 32
IS 8
BP 870
EP 876
DI 10.1002/elps.201000435
PG 7
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 747WW
UT WOS:000289352900011
PM 21374630
DA 2026-05-27
ER

PT J
AU Zhou, C
   Jiao, L
   Teng, L
   Ding, JW
AF Zhou, Chun
   Jiao, Lu
   Teng, Lin
   Ding, Jiawang
TI Effect of salidroside on ventricular remodeling after acute myocardial
   infarction
SO TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
LA English
DT Article
DE Salidroside; Wnt; beta-catenin; Acute myocardial infarction
AB Purpose: To investigate the remodeling influence of salidroside (SAL) on the ventricles following acute myocardial infarction (AMI) in rats, and the processes involved.
   Methods: A total of 65 Sprague Dawley (SD) rats were assigned to 5 groups: sham (n = 13), model, and low-, medium- and high-dose SAL groups given SAL at doses of 12, 34, and 36 mg/day, respectively, with 13 rats in each group. Changes in pathological structure, collagen area, ratio of collagen I/collagen III, left ventricular mass index (LVW/BW), ratio of cardiac weight to body weight (HW/BW), creatine kinase MB isoenzyme (CK-MB), lactate dehydrogenase-1 (LDH-1), endothelin (ET), laminin (LN), and hyaluronic acid (HA) were evaluated. Expression levels of dishevelled-1 (DVL-1) and beta-catenin in myocardial tissues of the rats were also determined.
   Results: The LVW/BW values were significantly higher in the low SAL and medium SAL groups than those in AMI rats, while the ratio of collagen I/III and expression levels of DVL-1 and beta-catenin proteins were significantly lower than those in the model group (p < 0.05). The myocardial structure of rats in the sham group was normal, with no obvious lesions. The levels of CK-MB, LDH-1, ET, LN, and HA in medium and high-dose SAL groups were significantly lower than those in the model group (p < 0.05).
   Conclusion: Salidroside mitigates remodeling of ventricles following AMI in rats by modulating the Wnt/beta-catenin signal route.
C1 [Zhou, Chun; Jiao, Lu; Teng, Lin; Ding, Jiawang] China Three Gorgers Univ, Yichang Cent Peoples Hosp Yichang, Coll Clin Med Sci 1, Yichang 443000, Hubei, Peoples R China.
RP Ding, JW (corresponding author), China Three Gorgers Univ, Yichang Cent Peoples Hosp Yichang, Coll Clin Med Sci 1, Yichang 443000, Hubei, Peoples R China.
EM zhouchun19860903@163.com
RI Teng, Lin/AAY-1325-2020; ding, jiawang/M-8804-2014
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NR 17
TC 0
Z9 0
U1 1
U2 8
PU PHARMACOTHERAPY GROUP
PI BENIN CITY
PA UNIV BENIN, FACULTY PHARMACY, BENIN CITY, 00000, NIGERIA
SN 1596-5996
J9 TROP J PHARM RES
JI Trop. J. Pharm. Res.
PD DEC
PY 2022
VL 21
IS 12
BP 2641
EP 2646
DI 10.4314/tjpr.v21i12.19
PG 6
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 9R3VH
UT WOS:000945582800019
OA gold
DA 2026-05-27
ER

PT J
AU Zhang, SY
   Yu, ML
   Wang, F
   Li, S
   Li, XF
   Hu, HY
   Zhang, Z
   Zhu, XP
   Tian, WQ
AF Zhang, Saiya
   Yu, Meilu
   Wang, Fen
   Li, Sha
   Li, Xuefei
   Hu, Hongyu
   Zhang, Zhen
   Zhu, Xiangpeng
   Tian, Weiqian
TI Salidroside promotes liver regeneration after partial hepatectomy in
   mice by modulating NLRP3 inflammasome-mediated pyroptosis pathway
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Salidroside; Liver regeneration; NLRP3; Pyroptosis
ID CELL-DEATH; INJURY; PROTEIN
AB Insufficient residual liver tissue after partial hepatectomy (PH) may lead to serious complications such as hepatic failure and small-for-size syndrome. Salidroside (SAL) is obtained from Rhodiola rosea through modernized separation and extraction and has been validated for treating various liver diseases. It's yet unknown, nevertheless, how SAL affects liver regeneration after PH. This study aimed to determine whether SAL could promote liver regeneration after PH in mice. We demonstrated that SAL could attenuate liver injury after PH and promote hepatocyte proliferation and liver mass recovery. Mechanistically, SAL inhibited the NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome, attenuating pyroptosis. RNA-seq analysis indicated that SAL downregulated the transcription of NLRP3 and GSDMD genes and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the NOD-like receptor signaling pathway was significantly enriched in down-regulated signaling pathways. Notably, SAL in combination with the NLRP3 inhibitor MCC950 did not further inhibit NLRP3 inflammasome and promote liver mass recovery. In summary, our findings proved that SAL could be a potential agent for improving liver function and promoting liver regeneration after PH.
C1 [Zhang, Saiya; Yu, Meilu; Wang, Fen; Li, Sha; Li, Xuefei; Hu, Hongyu; Zhang, Zhen; Zhu, Xiangpeng; Tian, Weiqian] Nanjing Univ Chinese Med, Affiliated Hosp, Jiangsu Prov Hosp Chinese Med, Dept Anesthesiol, Nanjing 210029, Peoples R China.
C3 Nanjing University of Chinese Medicine
RP Tian, WQ (corresponding author), Nanjing Univ Chinese Med, Affiliated Hosp, Jiangsu Prov Hosp Chinese Med, Dept Anesthesiol, Nanjing 210029, Peoples R China.
EM twq1972@163.com
RI Yu, Meilu/NPI-7198-2025
OI Tian, Weiqian/0000-0001-7474-4203
FU Project of Jiangsu Province Grad-uate Research Innovation Project,
   Nanjing University of Chinese
FX This study was supported by the Project of Jiangsu Province Grad-uate
   Research Innovation Project, Nanjing University of Chinese
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NR 43
TC 1
Z9 1
U1 6
U2 14
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD NOV 26
PY 2024
VL 735
AR 150678
DI 10.1016/j.bbrc.2024.150678
EA SEP 2024
PG 10
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA G3H7P
UT WOS:001315589900001
PM 39270555
DA 2026-05-27
ER

PT J
AU Zhu, LP
   Wei, TT
   Gao, J
   Chang, XY
   He, H
   Miao, MX
   Yan, TH
AF Zhu, Lingpeng
   Wei, Tingting
   Gao, Jing
   Chang, Xiayun
   He, He
   Miao, Mingxing
   Yan, Tianhua
TI Salidroside attenuates lipopolysaccharide (LPS) induced serum cytokines
   and depressive-like behavior in mice
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Salidroside; Lipopolysaccharide; Depression; Inflammation; BDNF
ID NEUROTROPHIC FACTOR; ANTIDEPRESSANTS; RESPONSES; SURVIVAL; STRESS
AB The aim of the study was to investigate the effects and possible underlying mechanism of salidroside (Sal) on lipopolysaccharide (LPS)-induced depression-like behavior in mice. Sal (12 mg/kg and 24 mg/kg) and fluoxetine (20 mg/kg) were administered intragastrically once daily for 5 days. At the 5th day, LPS (0.5 mg/kg) was injected intraperitoneally 30 min after drug administration. Levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in serum were measured by ELISA. Levels of neurotransmitters like norepinephrine (NE) and 5-hydroxytryptamine (5-HT) in the prefrontal cortex were detected by HPLC-MS. Further, brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB) and Nuclear factor-kappa B (NF-kappa B) in hippocampal was determined by western blot analysis. Our data showed that pretreatment with Sal dramatically attenuated LPS-induced inflammatory response, decrease of NE and 5-HT levels in the prefrontal cortex. In addition, Sal increased expression levels of BNDF and TrkB. These results suggested that Sal may play a neuroprotective role through the BDNF/TrkB signaling pathway. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
C1 [Zhu, Lingpeng; Wei, Tingting; Gao, Jing; Chang, Xiayun; He, He; Miao, Mingxing; Yan, Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Jiangsu, Peoples R China.
C3 China Pharmaceutical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Jiangsu, Peoples R China.
EM miaomingxing25@126.com; yantianhuabest@126.com
RI he, he/JPL-3505-2023; Su, Tianyuan/Y-7054-2019
FU National Twelve Five Major Drug Discovery Project [2011ZX09102-002-01]
FX This work was supported by National Twelve Five Major Drug Discovery
   Project (2011ZX09102-002-01).
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NR 33
TC 92
Z9 98
U1 2
U2 38
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD OCT 8
PY 2015
VL 606
BP 1
EP 6
DI 10.1016/j.neulet.2015.08.025
PG 6
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CU2IJ
UT WOS:000363346900001
PM 26300543
DA 2026-05-27
ER

PT J
AU Lu, GQ
   Sun, HY
   Xu, MY
   Sun, ZY
   Tang, Y
   Chen, Q
   Jiang, WD
   Chen, ZY
   Wang, L
   Liu, LQ
   Gao, Q
   Tang, B
   Kang, PF
AF Lu, Guo-Qing
   Sun, Hong-Yan
   Xu, Mei-Yang
   Sun, Zheng-Yu
   Tang, Ying
   Chen, Qing
   Jiang, Wen-Di
   Chen, Zi-Yi
   Wang, Lei
   Liu, Le-Qiang
   Gao, Qin
   Tang, Bi
   Kang, Pin-Fang
TI Salidroside ameliorates monocrotaline-induced pulmonary arterial
   hypertension in rats by modulating BKCa channels
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Pulmonary arterial hypertension; Salidroside; BKCa; K plus channels;
   Proliferation; Apoptosis
ID PROTEIN-KINASE-C; CA2+-ACTIVATED K+ CHANNELS; SMOOTH-MUSCLE-CELLS;
   POTASSIUM CHANNEL; CHRONIC HYPOXIA; ION CHANNELS; EXPRESSION; CA2+;
   ACTIVATION; RECEPTORS
AB Salidroside (Sal) is a natural active ingredient extracted from Crassulaceae plants, which has pharmacological effects such as anti-tumor, anti-oxidation, and cardiovascular protection. Potassium channel function in pulmonary artery smooth muscle cells (PASMCs) is crucial in the development of pulmonary arterial hypertension (PAH). This study explored the effects of Sal on large-conductance calcium-activated potassium channels (BKCa) in these cells, focusing on the mechanisms underlying its protective effect in PAH. A rat model of PAH was established using monocrotaline (MCT) alongside an in vitro model of primary PASMCs stimulated by plateletderived growth factor-BB. This study thoroughly assesses Salidroside's impact on PAH across tissue function, molecular mechanisms, and electrophysiological characteristics. Our results show that Sal treatment reduced right ventricular pressure in MCT-induced PAH rats, ameliorated pulmonary vascular remodeling and right ventricular reconstruction, and enhanced pulmonary vasoconstriction and relaxation activity. It increased the expression of BKCa channel proteins on the membrane of PASMCs, inhibited the proliferation of PASMCs, promoted their apoptosis, and improved the electrophysiological remodeling of PASMCs and pulmonary vascular remodeling caused by PAH. Activation and excessive expression of PKC alpha markedly suppressed BKCa channel function. Sal was able to activate BKCa channels by inhibiting PKC alpha, leading to enhanced K+ efflux, cellular hyperpolarization, and vasodilation. In conclusion,by reinstating BKCa channel activity in PASMCs, Sal rectified the dysregulation between cell proliferation and apoptosis within the pulmonary vasculature. This mechanism, potentially mediated indirectly by Sal's modulation of PKC alpha, offers a novel therapeutic approach for PAH.
C1 [Lu, Guo-Qing; Sun, Hong-Yan; Xu, Mei-Yang; Sun, Zheng-Yu; Tang, Ying; Chen, Qing; Wang, Lei; Tang, Bi; Kang, Pin-Fang] Bengbu Med Univ, Affiliated Hosp 1, Dept Cardiovasc Dis, 287 Chang Huai Avenu, Bengbu 233004, Anhui, Peoples R China.
   [Jiang, Wen-Di; Chen, Zi-Yi] Bengbu Med Univ, Key Lab Canc Res, Clin Lab Diag, Bengbu 233000, Peoples R China.
   [Liu, Le-Qiang] Bengbu Med Univ, Sch Clin Med, Bengbu 233000, Anhui, Peoples R China.
   [Lu, Guo-Qing; Sun, Hong-Yan; Xu, Mei-Yang; Sun, Zheng-Yu; Tang, Ying; Chen, Qing; Wang, Lei; Kang, Pin-Fang] Bengbu Med Univ, Key Lab Basic & Clin Cardiovasc & Cerebrovasc, Bengbu 233004, Anhui, Peoples R China.
   [Gao, Qin] Bengbu Med Univ, Dept Physiol, Bengbu 233000, Anhui, Peoples R China.
   [Liu, Le-Qiang] Bengbu Med Univ, Sch Gen Practice Med, Bengbu 233000, Anhui, Peoples R China.
C3 Bengbu Medical University; Bengbu Medical University; Bengbu Medical
   University; Bengbu Medical University; Bengbu Medical University; Bengbu
   Medical University
RP Tang, B; Kang, PF (corresponding author), Bengbu Med Univ, Affiliated Hosp 1, Dept Cardiovasc Dis, 287 Chang Huai Avenu, Bengbu 233004, Anhui, Peoples R China.
EM kangpinfang.1016@163.com
OI Chen, ziyi/0009-0009-6757-167X
FU National Natural Science Foundation of China [81970313]; Collaborative
   innovation project of Anhui Universities [GXXT-2020-019]; Anhui Province
   Natural Founda-tion of China [2208085MH192]; Anhui Province Outstanding
   Youth Project of China [2022AH030141]; Anhui Province excellent
   scientific research and innovation team of China [2022AH010083];
   Research Innovation Team of Bengbu Medical College in Anhui Province of
   China [BYKC201906]; Natural Science Research Project of Anhui
   Educational Committee in Anhui Province of China [202304295107020034]
FX The present study was funded by the National Natural Science Foundation
   of China (81970313) , Collaborative innovation project of Anhui
   Universities (GXXT-2020-019) , Anhui Province Natural Founda-tion of
   China (Grant nos. 2208085MH192) , Anhui Province Outstanding Youth
   Project of China (2022AH030141) , Anhui Province excellent scientific
   research and innovation team of China (2022AH010083) , Research
   Innovation Team of Bengbu Medical College in Anhui Province of China
   (BYKC201906) , Natural Science Research Project of Anhui Educational
   Committee in Anhui Province of China (202304295107020034) .
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NR 58
TC 0
Z9 0
U1 1
U2 3
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD OCT 5
PY 2025
VL 1004
AR 177950
DI 10.1016/j.ejphar.2025.177950
EA JUL 2025
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 5TQ2J
UT WOS:001544049700002
PM 40714070
DA 2026-05-27
ER

PT J
AU Zhang, Q
   Li, L
   Wang, YQ
   Wu, HT
   Zhu, BW
AF Zhang, Qian
   Li, Lin
   Wang, Yu-Qiao
   Wu, Hai -Tao
   Zhu, Bei-Wei
TI Improving salidroside stability using water-in-oil-in-water emulsion
   with whey protein isolate: Formation and characterization
SO LWT-FOOD SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Salidroside; W/O/W emulsion; Whey protein isolate; Characterization;
   Storage stability
ID RELEASE; FORMULATION; CHITOSAN; QUALITY
AB A water -in -oil -in -water (W/O/W) emulsion for the encapsulation of salidroside (Sal) was constructed. This study aimed to detect the impact of whey protein isolate (WPI) on the microstructure and stability of Sal W/O/W emulsion, which was prepared by two-step emulsification. First, Sal and sodium alginate (SA) were added to the inner water phase, and polyglycerol polyricinoleate (PGPR) was added to the oil phase to prepare a water -in -oil (W/O) emulsion. Second, different concentrations of WPI were added to the outer water phase containing SA to prepare a Sal W/O/W emulsion. The microstructure, stability, moisture distribution, rheological properties, and encapsulation efficiency of Sal were detected. The results showed that the particle size and the size distribution range became smaller and narrower with increasing WPI concentration. When the concentration of WPI was greater than 2%, the double -layer structure remained stable over 28 days of storage at 4 degrees C. Moreover, when the WPI concentration reached 4%, the entrapment efficiency of Sal was the highest. These results indicated that the optimum concentration of WPI was 4%.
C1 [Zhang, Qian; Zhu, Bei-Wei] Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Jilin, Peoples R China.
   [Li, Lin; Wang, Yu-Qiao; Wu, Hai -Tao; Zhu, Bei-Wei] Dalian Polytech Univ, Sch Food Sci & Technol, Collaborat Innovat Ctr Seafood Deep Proc, SKL Marine Food Proc & Safety Control,Natl Engn Re, Dalian 116034, Peoples R China.
C3 Jilin University; Dalian Polytechnic University
RP Zhu, BW (corresponding author), Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Jilin, Peoples R China.; Wu, HT; Zhu, BW (corresponding author), Dalian Polytech Univ, Sch Food Sci & Technol, Collaborat Innovat Ctr Seafood Deep Proc, SKL Marine Food Proc & Safety Control,Natl Engn Re, Dalian 116034, Peoples R China.
EM wht205@163.com; zhubeiwei@163.com
FU Science and Technology Program of Liaoning Province [2022JH1/10900010]
FX This work was supported by the Science and Technology Program of
   Liaoning Province (2022JH1/10900010) .
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NR 46
TC 11
Z9 11
U1 17
U2 64
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0023-6438
EI 1096-1127
J9 LWT-FOOD SCI TECHNOL
JI LWT-Food Sci. Technol.
PD MAY 15
PY 2024
VL 200
AR 116189
DI 10.1016/j.lwt.2024.116189
EA MAY 2024
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA TP0G1
UT WOS:001242340200001
OA gold
DA 2026-05-27
ER

PT J
AU Pu, WL
   Zhang, MY
   Bai, RY
   Sun, LK
   Li, WH
   Yu, YL
   Zhang, Y
   Song, L
   Wang, ZX
   Peng, YF
   Shi, H
   Zhou, K
   Li, TX
AF Pu, Wei-ling
   Zhang, Meng-ying
   Bai, Ru-yu
   Sun, Li-kang
   Li, Wen-hua
   Yu, Ying-li
   Zhang, Yue
   Song, Lei
   Wang, Zhao-xin
   Peng, Yan-fei
   Shi, Hong
   Zhou, Kun
   Li, Tian-xiang
TI Anti-inflammatory effects of Rhodiola rosea L.: A review
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Rhodiola rosea L.; Salidroside; Sofren injection; Anti-Inflammation
ID INDUCED RAT MODEL; CELL-DEATH; TARGETING INFLAMMATION; COGNITIVE
   IMPAIRMENT; HIPPOCAMPAL-NEURONS; ACTIVATOR PROTEIN-1;
   ALZHEIMERS-DISEASE; KAPPA-B; SALIDROSIDE; CANCER
AB Rhodiola rosea L., a worldwide botanical adaptogen, has been confirmed to possess protective effects of inflammatory injury for many diseases, including cardiovascular diseases, neurodegenerative diseases, diabetes, sepsis, and cancer. This paper is to review the recent clinical and experimental researches about the anti-inflammatory effects and the related mechanisms of Rhodiola rosea L. extracts, preparations, and the active compounds. From the collected information reviewed, this paper will provide the theoretical basis for its clinical application, and provide the evidences or guidance for future studies and medicinal exploitations of Rhodiola rosea L.
C1 [Pu, Wei-ling; Zhang, Meng-ying; Bai, Ru-yu; Yu, Ying-li; Zhang, Yue; Song, Lei; Wang, Zhao-xin; Shi, Hong; Zhou, Kun] Tianjin Univ Tradit Chinese Med, Inst Tradit Chinese Med, Tianjin 301617, Peoples R China.
   [Pu, Wei-ling; Yu, Ying-li; Zhang, Yue; Song, Lei; Wang, Zhao-xin; Shi, Hong; Zhou, Kun] Tianjin Univ Tradit Chinese Med, Tianjin Key Lab Chinese Med Pharmacol, Tianjin 301617, Peoples R China.
   [Zhang, Meng-ying; Bai, Ru-yu; Sun, Li-kang; Peng, Yan-fei] Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 301617, Peoples R China.
   [Li, Wen-hua] Xizang Minzu Univ, Coll Med, Tibetan Natl Univ, Xianyang 712082, Shaanxi, Peoples R China.
   [Zhou, Kun] Tianjin Univ Tradit Chinese Med, Key Lab Pharmacol Tradit Chinese Med Formulae, Minist Educ, Tianjin 301617, Peoples R China.
   [Li, Tian-xiang] Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 301617, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine; Tianjin University of Traditional
   Chinese Medicine; Xizang Minzu University; Tianjin University of
   Traditional Chinese Medicine; Tianjin University of Traditional Chinese
   Medicine
RP Sun, LK (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 301617, Peoples R China.; Li, WH (corresponding author), Xizang Minzu Univ, Coll Med, Tibetan Natl Univ, Xianyang 712082, Shaanxi, Peoples R China.
EM likang.sun@bluewin.ch; xzmylwh@163.com
RI Sun, Li-kang/D-6127-2013; zhang, mengying/KBB-7510-2024
OI Sun, Li-kang/0000-0003-0287-7407; 
FU natural Science Foundation Tibetan Autonomous Region of China
   [XZ2017ZRG-67(Z)]; Tianjin University of Traditional Chinese Medicine
   Foundation
FX The authors thank Mrs. Margaret Gebauer (Chingcura, Center for
   Traditional Chinese Medicine, Zurich 8032, Switzerland) for the kind
   linguistic editing. This work was supported by natural Science
   Foundation Tibetan Autonomous Region of China (XZ2017ZRG-67(Z) to LWH &
   SLK); Tianjin University of Traditional Chinese Medicine Foundation (to
   SLK).
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NR 92
TC 173
Z9 198
U1 16
U2 150
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD JAN
PY 2020
VL 121
AR 109552
DI 10.1016/j.biopha.2019.109552
PG 10
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA JT1GJ
UT WOS:000500746200025
PM 31715370
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Kim, SY
   Song, MK
   Jeon, JH
   Ahn, JH
AF Kim, Song-Yi
   Song, Min Kyung
   Jeon, Ju Hyun
   Ahn, Joong-Hoon
TI Current Status of Microbial Phenylethanoid Biosynthesis
SO JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
LA English
DT Review
DE Metabolic engineering; microbial production; phenylethanoids
ID ACID PHENETHYL ESTER; RHODIOLA-ROSEA EXTRACT; BIOCHEMICAL EVALUATION;
   PHENOLIC-COMPOUNDS; ESCHERICHIA-COLI; OLIVE OIL; SALIDROSIDE;
   2-PHENYLETHANOL; DECARBOXYLATION; PHENYLALANINE
AB Phenylethanoids, including 2-phenylethanol, tyrosol, and salidroside are a group of phenolic compounds with a C6-C2 carbon skeleton synthesized by plants. Phenylethanoids display a variety of biological activities, including antibacterial, anticancer, anti-inflammatory, neuroprotective, and anti-asthmatic activities. Recently, successful microbial synthesis of phenylethanoids through metabolic engineering and synthetic biology approaches has been reported and could allow phenylethanoid production from alternative microbial sources. Here, we review the recent achievements in the synthesis of phenylethanoids by microorganisms. The work done so far will contribute to the production of diverse phenylethanoids using various microbial systems and facilitate exploration of further diverse biological activities of phenylethanoids.
C1 [Kim, Song-Yi; Song, Min Kyung; Jeon, Ju Hyun; Ahn, Joong-Hoon] Konkuk Univ, Biomol Informat Ctr, Dept Integrat Biosci & Biotechnol, Seoul 05029, South Korea.
C3 Konkuk University
RP Ahn, JH (corresponding author), Konkuk Univ, Biomol Informat Ctr, Dept Integrat Biosci & Biotechnol, Seoul 05029, South Korea.
EM jhahn@konkuk.ac.kr
FU Next Generation BioGreen 21 Program [PJ01326001]; Rural Development
   Administration, and Priority Research Centers Program through the
   National Research Foundation of Korea - Ministry of Education, Science
   and Technology [2009-0093824]
FX This work was supported by a grant from the Next Generation BioGreen 21
   Program (PJ01326001), Rural Development Administration, and Priority
   Research Centers Program through the National Research Foundation of
   Korea funded by the Ministry of Education, Science and Technology
   (2009-0093824).
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NR 55
TC 12
Z9 17
U1 3
U2 80
PU KOREAN SOC MICROBIOLOGY & BIOTECHNOLOGY
PI SEOUL
PA KOREA SCI TECHNOL CENTER #507,  635-4 YEOGSAM-DONG, KANGNAM-GU, SEOUL
   135-703, SOUTH KOREA
SN 1017-7825
EI 1738-8872
J9 J MICROBIOL BIOTECHN
JI J. Microbiol. Biotechnol.
PD AUG
PY 2018
VL 28
IS 8
BP 1225
EP 1232
DI 10.4014/jmb.1805.05021
PG 8
WC Biotechnology & Applied Microbiology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Microbiology
GA GR6MH
UT WOS:000442767000001
PM 29996621
DA 2026-05-27
ER

PT J
AU Liu, ZJ
   Ma, XB
   Li, SY
   Qiu, JJ
   Liu, SY
   Huang, ZF
   Lin, HL
   Abd El-Aty, AM
AF Liu, Zijie
   Ma, Xingbin
   Li, Shuyu
   Qiu, Jiajie
   Liu, Siyu
   Huang, Zhifeng
   Lin, Hongling
   Abd El-Aty, A. M.
TI Development of a biocompatible green drug release system using
   salidroside-TiO2-doped chitosan oligosaccharide molecularly imprinted
   polymers
SO ARABIAN JOURNAL OF CHEMISTRY
LA English
DT Article
DE Surface molecularly; imprinted polymer; Novel functional monomer;
   Diethylene glycol; Sustained release; Salidroside; dimethacrylate
ID MICROSPHERES
AB This study focuses on creating a green drug release system using a food-grade titanium dioxide (TiO2) material through surface molecular imprinting. Salidroside (SD) was chosen as the template molecule to synthesize molecularly imprinted polymers (SDT-MIP) utilizing TiO2-doped chitosan oligosaccharides as the functional monomer. The SDT-MIPs were characterized using multiple techniques, and their effectiveness was evaluated through an in vitro release study. Additionally, the affinity of SDT-MIPs toward the template molecule was examined using Langmuir and Freundlich adsorption models. The Langmuir model revealed a maximum capacity of 170.41 mg/g and an imprinted factor of 3.4. The study demonstrated that drug release from the SDT-MIPs in simulated gastrointestinal fluid primarily occurred through pure Fick diffusion. The release kinetics exhibited diffusion coefficients ranging from 3.38 x 10-3 cm2/s to 2.78 x 10-2 cm2/s, indicating their biocompatibility and potential application in drug delivery. Furthermore, the SDT-MIP demonstrated no adverse impact on cell viability even at concentrations as high as 1000 lg/mL. The survival rate of cells cultivated in the presence of SDT-MIP solution exceeded 120 & PLUSMN; 12.46%,
C1 [Liu, Zijie; Ma, Xingbin; Li, Shuyu; Qiu, Jiajie; Liu, Siyu; Huang, Zhifeng] Guangdong Ocean Univ, Coll Coastal Agr Sci, Zhanjiang 524088, Guangdong, Peoples R China.
   [Lin, Hongling] Chinese Acad Trop Agr Sci, Southern Subtrop Crop Res Inst, Zhanjiang Expt Stn, Zhanjiang 524013, Peoples R China.
   [Abd El-Aty, A. M.] Cairo Univ, Fac Vet Med, Dept Pharmacol, Giza 12211, Egypt.
   [Abd El-Aty, A. M.] Qilu Univ Technol, Shandong Acad Sci, State Key Lab Biobased Mat & Green Papermaking, Jinan 250353, Peoples R China.
   [Abd El-Aty, A. M.] Ataturk Univ, Med Fac, Dept Med Pharmacol, TR-25240 Erzurum, Turkiye.
C3 Guangdong Ocean University; Chinese Academy of Tropical Agricultural
   Sciences; Egyptian Knowledge Bank (EKB); Cairo University; Qilu
   University of Technology; Ataturk University
RP Ma, XB (corresponding author), Guangdong Ocean Univ, Coll Coastal Agr Sci, Zhanjiang 524088, Guangdong, Peoples R China.
EM mxb1984612@126.com; abdelaty44@hotmail.com
RI ; Abd El-Aty, A. M/H-8216-2018
OI Liu, Zijie/0000-0001-7310-2479; Abd El-Aty, A. M/0000-0001-6596-7907
FU Natural Science Foundation of Guangdong Province,China
   [2022A1515010576]; Project of Guangdong International, Hong Kong, Macao,
   and Taiwan high-end talent exchange program [K21425]; Project of
   Enhancing School with Innovation of Guangdong Ocean University
   [B20413/300702, B21129]; Program for Scientific Research Start-Fund of
   Guangdong Ocean University [101402/R20063]
FX This study was funded by a project supported by the Natural Science
   Foundation of Guangdong Province,China. (Grant No. 2022A1515010576), and
   the Project of Guangdong International, Hong Kong, Macao, and Taiwan
   high-end talent exchange program (NO. K21425), the Project of Enhancing
   School with Innovation of Guangdong Ocean University<EM><STRONG>
   </STRONG></EM>[grant number: B20413/300702, B21129] and the Program for
   Scientific Research Start-Fund of Guangdong Ocean University [grant
   number: 101402/R20063].
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U2 35
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1878-5352
EI 1878-5379
J9 ARAB J CHEM
JI Arab. J. Chem.
PD OCT
PY 2023
VL 16
IS 10
AR 105130
DI 10.1016/j.arabjc.2023.105130
EA JUL 2023
PG 13
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA O4RR6
UT WOS:001043707700001
OA gold
DA 2026-05-27
ER

PT J
AU Zhan, XJ
   He, MS
   Pei, JR
   Fan, WJ
   Mwangi, CN
   Zhang, P
   Chai, X
   Jiang, MM
AF Zhan, Xiujun
   He, Mingshuai
   Pei, Jierong
   Fan, Wenjing
   Mwangi, Charity Ngina
   Zhang, Peng
   Chai, Xin
   Jiang, Miaomiao
TI Natural Phenylethanoid Supplementation Alleviates Metabolic Syndrome in
   Female Mice Induced by High-Fructose Diet
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; fructose; gut microbiota; metabolic syndrome; hepatic
   protection
ID GUT MICROBIOTA; OLIVE OIL; HYDROXYTYROSOL; TYROSOL; INHIBITION; GLUCOSE;
   CHINESE; PROFILE
AB Tyrosol (T), hydroxytyrosol (H), and salidroside (S) are typical phenylethanoids and also powerful dietary antioxidants. This study aimed at evaluating the influence of three natural phenylethanoids, which are dietary phenylethanoids of natural origins, on reversing gut dysbiosis and attenuating nonalcoholic fatty liver features of the liver induced by metabolic syndrome (MetS) mice. C57BL/6J female mice induced with high-fructose diet were established and administrated with salidroside, tyrosol, and hydroxytyrosol for 12 weeks, respectively. Biochemical analysis showed that S, T, and H significantly improved glucose metabolism and lipid metabolism, including reduced levels of total cholesterol insulin (INS), uric acid, low-density lipoprotein cholesterol (LDL-C), and aspartate aminotransferase (ALT). Histopathological observation of the liver confirmed the protective effects of S, T, and H against hepatic steatosis, which were demonstrated by the results of metabolomic analysis, such as the improvement in glycolysis, purine metabolism, bile acid, fatty acid metabolism, and choline metabolism. Additionally, 16S rRNA gene sequence data revealed that S, T, and H could enhance the diversity of gut microbiota. These findings suggested that S, T, and H probably suppress lipid accumulation and have hepatoprotective effects and improve intestinal microflora disorders to attenuate metabolic syndromes.
C1 [Zhan, Xiujun; He, Mingshuai; Pei, Jierong; Fan, Wenjing; Mwangi, Charity Ngina; Zhang, Peng; Chai, Xin; Jiang, Miaomiao] Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin, Peoples R China.
   [Zhan, Xiujun; He, Mingshuai; Pei, Jierong; Fan, Wenjing; Zhang, Peng; Chai, Xin; Jiang, Miaomiao] Haihe Lab Modern Chinese Med, Tianjin, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine
RP Jiang, MM (corresponding author), Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin, Peoples R China.; Jiang, MM (corresponding author), Haihe Lab Modern Chinese Med, Tianjin, Peoples R China.
EM miaomiaojiang@126.com
RI Mwangi, Charity/JRY-0199-2023
FU Tianjin Committee of Science and Technology of China;  [21ZYJDJC00080]; 
   [20ZYJDJC00120]
FX Funding This study was supported by the Tianjin Committee of Science and
   Technology of China (Nos. 21ZYJDJC00080 and 20ZYJDJC00120).
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NR 52
TC 7
Z9 9
U1 1
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 19
PY 2022
VL 13
AR 850777
DI 10.3389/fphar.2022.850777
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6Q0YV
UT WOS:000891347900001
PM 35928270
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Ni, GL
   Cui, R
   Shao, AM
   Wu, ZM
AF Ni, Gui-Lian
   Cui, Rong
   Shao, Ai-Min
   Wu, Zhong-Min
TI Salidroside Ameliorates Diabetic Neuropathic Pain in Rats by Inhibiting
   Neuroinflammation
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE Salidroside; Diabetic neuropathic pain; Neuroinflammation; P2X(7)
   receptor
ID P2X(7) RECEPTOR; INFLAMMATION; SENSITIZATION
AB More than half of diabetic patients suffer from intractable neuropathic pain. As inflammation plays an important role in diabetic neuropathic pain, anti-inflammatory drugs might have therapeutic potentials for neuropathic pain. Salidroside (SAL), a phenylpropanoid glucoside, modulates a variety of cell functions, including inflammation. Here, we explored anti-nociceptive and anti-inflammatory effects of SAL on Zucker diabetic fatty rats with type 2 diabetes (DM rats). DM rats were tested for mechanical and thermal hyperalgesia using von Frey filament and plantar hot box test, respectively. The anti-nociceptive effect of chronic SAL (25-100 mg/kg, per oral) treatment was tested. The expression of inflammatory cytokines (TNF-alpha and IL-1 beta) and P2X(7) receptors in spinal cord and sciatic nerve were measured with ELISA. SAL alleviated mechanical and thermal hyperalgesia and reduced TNF-alpha and IL-1 beta in sciatic nerve and spinal cord in DM rats. Furthermore, SAL reduced P2X(7) receptor upregulation in spinal cord of DM rats and directly inhibited P2X(7) receptors expressed in HEK293 cells. This study provides evidence that SAL attenuated nociception in diabetic neuropathic pain rat models probably through inhibiting neuroinflammation and P2X(7) receptors.
C1 [Ni, Gui-Lian; Cui, Rong; Shao, Ai-Min; Wu, Zhong-Min] First Peoples Hosp Linhai City, Dept Neurol, Linhai 317000, Peoples R China.
   [Wu, Zhong-Min] Taizhou Univ, Coll Med, Dept Anat, Taizhou 318000, Peoples R China.
C3 Taizhou University
RP Wu, ZM (corresponding author), First Peoples Hosp Linhai City, Dept Neurol, Linhai 317000, Peoples R China.; Wu, ZM (corresponding author), Taizhou Univ, Coll Med, Dept Anat, Taizhou 318000, Peoples R China.
EM zhongminwuu@sina.com
FU Zhejiang Provincial Science and Technology Department of Public Welfare
   Technology Application Project [2017C37124]
FX This work was supported by Zhejiang Provincial Science and Technology
   Department of Public Welfare Technology Application Project
   (2017C37124). We thank Professor Shucai Ling for his valuable
   suggestions on this paper.
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BP 9
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SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA FF5PN
UT WOS:000409045200002
PM 28741143
DA 2026-05-27
ER

PT J
AU Ao, WY
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   Li, T
AF Ao, Weiyi
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   Li, Tian
TI Research progress on the mechanism of antidepressant effect of
   salidroside
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Salidroside (SAL); Depression; Mechanism; Pharmacology
ID RHODIOLA-ROSEA L.; LIPOPOLYSACCHARIDE LPS; TISSUE DISTRIBUTION;
   DEPRESSION; STRESS; BDNF; ACTIVATION; SYSTEM; BRAIN; PHARMACOKINETICS
AB Current pharmacological interventions for depression, including selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), noradrenergic and specific serotonergic antidepressants (NaSSAs), tricyclic and tetracyclic antidepressants, and monoamine oxidase inhibitors (MAOIs), are often constrained by side effects, such as gastrointestinal disturbances, headaches, dizziness, and sexual dysfunction, as well as variable therapeutic efficacy and delayed onset of action. In recent years, increasing interest has been directed toward identifying novel antidepressant agents derived from traditional Chinese herbal medicines, with a growing body of preclinical studies supporting their potential utility. Salidroside (SAL), traditionally used to invigorate qi and enhance blood circulation, has demonstrated promising antidepressant properties. Accumulating evidence suggests that its therapeutic effects may involve multiple molecular mechanisms, including upregulation of the SIRT1/PGC-1 alpha signaling pathway to stimulate hippocampal neurogenesis, suppression of NLRP3 inflammasome-mediated pyroptosis via the P2X7/NF-kappa B/NLRP3 axis, downregulation of proinflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha), inhibition of microglial activation, enhancement of monoaminergic neurotransmission, and attenuation of lipopolysaccharide (LPS)-induced neuroinflammation. This review aims to comprehensively summarize the pharmacological activities and underlying molecular mechanisms of SAL in the context of antidepressant therapy.
C1 [Ao, Weiyi; Li, Tian] Chongqing Med Univ, Affiliated Hosp 1, Dept Reprod Med, Chongqing 400016, Peoples R China.
   [Ao, Weiyi; Li, Tian] Chongqing Med Univ, Coll Clin Med 1, Chongqing 400016, Peoples R China.
   [Gao, Wenbo] Huazhong Agr Univ, Coll Life Sci & Technol, Wuhan 430072, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University; Huazhong
   Agricultural University
RP Ao, WY; Li, T (corresponding author), Chongqing Med Univ, Affiliated Hosp 1, Dept Reprod Med, Chongqing 400016, Peoples R China.
EM ltianh98@163.com
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NR 114
TC 4
Z9 4
U1 8
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD SEP 23
PY 2025
VL 162
AR 115205
DI 10.1016/j.intimp.2025.115205
EA SEP 2025
PG 9
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA 5JB5G
UT WOS:001536874800001
PM 40651432
DA 2026-05-27
ER

PT J
AU Zhang, XY
   Shi, NN
   Chen, MH
   Liu, M
   Ju, RJ
   Liu, Y
   Kong, L
   Yu, Y
   Li, XT
AF Zhang, Xinyue
   Shi, Ningning
   Chen, Muhan
   Liu, Mo
   Ju, Ruijun
   Liu, Yang
   Kong, Liang
   Yu, Yang
   Li, Xuetao
TI Angiopep-2 modified dual drug-loaded liposomes with brain targeting
   functionality mitigate Alzheimer's disease-related symptoms in APP/PS-1
   mice
SO JOURNAL OF DRUG TARGETING
LA English
DT Article
DE Angiopep-2; liposome; Salidroside; Icariin; Alzheimer's disease
ID OXIDATIVE STRESS; SALIDROSIDE; STRATEGIES; NEURONS; BARRIER; MODEL
AB The blood-brain barrier (BBB) is a barrier that maintains brain homeostasis, but it is also one of the major problems that must be overcome in the development of Alzheimer's disease (AD) drugs. To solve this problem, Salidroside (Sal) and Icariin (Ica), drugs with neuroprotective effects were loaded into liposomes, and the targeting molecule Angiopep-2 was modified on the surface of liposomes (Ang-Sal/Ica-Lip), so that the constructed nano-drug delivery system could effectively cross the BBB and exert anti-AD effects. The prepared liposomes exhibited ideal physicochemical properties. In vitro and in vivo targeting studies showed that Ang-Sal/Ica liposome could cross the BBB to increase drug accumulation in the brain, and increase the uptake of N2a cells and bEnd.3 cells. The pharmacodynamic analysis in vivo showed that Ang-Sal/Ica liposome could reverse neuronal and synaptic damage, inhibit neuroinflammation and oxidative stress and improve learning and cognitive function. Therefore, Ang-Sal/Ica liposome may be a promising therapeutic strategy for mitigating AD-related symptoms.
C1 [Zhang, Xinyue; Chen, Muhan; Liu, Mo; Liu, Yang; Kong, Liang; Yu, Yang; Li, Xuetao] Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian 116600, Peoples R China.
   [Shi, Ningning] Shanxi Univ Tradit Chinese Med, Shanxi Key Lab Innovat Drug Treatment Serious Dis, Jinzhong, Peoples R China.
   [Ju, Ruijun] 967Th Hosp PLA Joint Logist Support Force, Pharm Dept, Dalian, Peoples R China.
C3 Liaoning University of Traditional Chinese Medicine
RP Yu, Y; Li, XT (corresponding author), Liaoning Univ Tradit Chinese Med, Sch Pharm, Dalian 116600, Peoples R China.
EM yuqn0702@163.com; lixuetao1979@163.com
RI Li, Xuetao/AAH-2890-2020; Yu, Yang/IVH-2833-2023
OI Li, Xuetao/0000-0002-0608-4669; 
FU National Natural Science Foundation of China [82204629, 81903813,
   81874347]; Program for Major Scientific and Medical Technology Problems
   of China Medicine Education Association [2020KTS004]; China Postdoctoral
   Science Foundation [2019M653973]
FX This work was supported by the National Natural Science Foundation of
   China (Grant Nos. 82204629, 81903813 and 81874347), Program for Major
   Scientific and Medical Technology Problems of China Medicine Education
   Association in 2020 (No. 2020KTS004) and China Postdoctoral Science
   Foundation (No. 2019M653973).
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NR 59
TC 24
Z9 26
U1 9
U2 58
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1061-186X
EI 1029-2330
J9 J DRUG TARGET
JI J. Drug Target.
PD JUL 3
PY 2023
VL 31
IS 6
BP 634
EP 645
DI 10.1080/1061186X.2023.2216405
EA MAY 2023
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA J8MS7
UT WOS:000995260800001
PM 37203195
DA 2026-05-27
ER

PT J
AU Zhong, DN
   Pan, YP
   Fan, H
   Lv, JL
AF Zhong, Dan-ni
   Pan, Yun-ping
   Fan, Heng
   Lv, Jie-li
TI Protective Effect of Salidroside on Acute Kidney Injury in Sepsis by
   Inhibiting Oxidative Stress, Mitochondrial Damage, and Cell Apoptosis
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE salidroside; acute kidney injury; sepsis; oxidative stress;
   mitochondrial damage; apoptosis
ID SEPTIC RATS
AB Acute kidney injury (AKI) is one of the common complications in patients with sepsis. We aimed to investigate the protective mechanism of salidroside (SLDS) on AKI induced by cecal ligation and perforation (CLP). We established a sepsis model using the CLP, and pretreated the mice with SLDS. We used biochemical methods to measure renal function, inflammatory factors and oxidase levels. We used transmission electron microscopy to observe mitochondrial damage, terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) to detect apoptosis in renal tubular epithelial cells (TECs), and RT-quantitative PCR (qPCR) to detect the expression of apoptotic genes. CLP induced renal pathological damage and decreased renal function, activated inflammatory factors and oxidases, leading to mitochondrial damage and increased apoptosis of TECs. SLDS pretreatment improved renal pathological damage, reduced tumor necrosis factor (TNF)-alpha, interleukin (IL)-6 and malondialdehyde levels, and increased the levels of glutathione peroxidase, superoxide dismutase and catalase. Moreover, SLDS stabilized mitochondrial damage induced by CLP, inhibited TECs apoptosis, increased Bcl-2 mRNA level, and decreased Bax and Caspase-3 mRNA levels. SLDS protects CLP induced AKI by inhibiting oxidative stress, mitochondrial damage, and cell apoptosis in TECs.
C1 [Zhong, Dan-ni; Lv, Jie-li] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China.
   [Zhong, Dan-ni] Ningbo 6 Hosp, Dept Pharm, Ningbo 315040, Zhejiang, Peoples R China.
   [Pan, Yun-ping] Ningbo 6 Hosp, Dept Intens Care Unit, Ningbo 315040, Zhejiang, Peoples R China.
   [Fan, Heng] Ningbo Univ, Affiliated Hosp 1, Dept Intens Care Unit, Ningbo 315000, Zhejiang, Peoples R China.
C3 Henan Medical University; Ningbo University
RP Lv, JL (corresponding author), Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China.; Fan, H (corresponding author), Ningbo Univ, Affiliated Hosp 1, Dept Intens Care Unit, Ningbo 315000, Zhejiang, Peoples R China.
EM peterbenny@163.com; jielilv2009@xxmu.edu.cn
FU Huadong Medicine Joint Funds of the Zhejiang Provin-cial Natural Science
   Foundation of China [LHDMZ23H050001]; Zhejiang Province Traditional
   Chinese Medicine Science and Technology Project [2023ZL159]; Zhejiang
   Provincial Medical and Health Science Foundation of China [2023KY251,
   2024KY312]; Project of Ningbo Key R&D Plan and "Unveiling and Leading"
   [2023Z174]; Natural Science Foundation of Ningbo [2022J202]; Ningbo
   Clinical Research Center for Emergency and Critical Diseases [2024L003]
FX This research was supported by the Huadong Medicine Joint Funds of the
   Zhejiang Provincial Natural Science Foundation of China under Grant No.
   LHDMZ23H050001, the Zhejiang Province Traditional Chinese Medicine
   Science and Technology Project under Grant No. 2023ZL159, the Zhejiang
   Provincial Medical and Health Science Foundation of China under Grant
   No. 2023KY251 and 2024KY312, the Project of Ningbo Key R&D Plan and
   "Unveiling and Leading" under Grant No. 2023Z174, the Natural Science
   Foundation of Ningbo under Grant No. 2022J202, and Ningbo Clinical
   Research Center for Emergency and Critical Diseases under Grant No.
   2024L003.
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TC 7
Z9 7
U1 1
U2 4
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
EI 1347-5215
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD SEP
PY 2024
VL 47
IS 9
BP 1550
EP 1556
DI 10.1248/bpb.b24-00470
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA G8B2B
UT WOS:001318817800003
PM 39313391
OA gold
DA 2026-05-27
ER

PT J
AU Wang, SH
   He, H
   Chen, L
   Zhang, W
   Zhang, XJ
   Chen, JZ
AF Wang, Songhai
   He, Hong
   Chen, Lei
   Zhang, Wei
   Zhang, Xiaojun
   Chen, Jianzong
TI Protective Effects of Salidroside in the MPTP/MPP+-Induced
   Model of Parkinson's Disease through ROS-NO-Related Mitochondrion
   Pathway
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE Parkinson's disease; Salidroside; Apoptosis; Reactive oxygen species;
   Nitric oxide; Mitochondrion
ID NITRIC-OXIDE; ALPHA-SYNUCLEIN; NIGROSTRIATAL DEGENERATION; INDUCED
   APOPTOSIS; OXIDATIVE STRESS; NEURONAL DEATH; MOUSE MODEL; TIME-COURSE;
   MPTP; DOPAMINE
AB Parkinson's disease is a progressive neurodegenerative disease causing tremor, rigidity, bradykinesia, and gait impairment. Oxidative stress and mitochondrial dysfunction play important roles in the development of Parkinson disease. Salidroside (Sal), a phenylpropanoid glycoside isolated from Rhodiola rosea L., has potent antioxidant properties. Previous work from our group suggests that Sal might protect dopaminergic neurons through inhibition of reactive oxygen species (ROS) and nitric oxide (NO) generation. In the present study, we investigated the protective effects of Sal in MPTP/MPP+ models of Parkinson's disease in an attempt to elucidate the underlying mechanism of protection. We found that Sal pretreatment protected dopaminergic neurons against MPTP/MPP+-induced toxicity in a dose-dependent manner by: (1) reducing the production of ROS-NO, (2) regulating the ratio of Bcl-2/Bax, (3) decreasing cytochrome-c and Smac release, and inhibiting caspase-3, caspas-6, and caspas-9 activation, and (4) reducing alpha-synuclein aggregation. The present study supports the hypothesis that Sal may act as an effective neuroprotective agent through modulation of the ROS-NO-related mitochondrial pathway in vitro and in vivo.
C1 [Wang, Songhai; He, Hong; Zhang, Wei; Chen, Jianzong] Fourth Mil Med Univ, Xijing Hosp, Res Ctr Tradit Chinese Med, Xian 710032, Peoples R China.
   [Chen, Lei] Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian 710038, Peoples R China.
   [Zhang, Xiaojun] Fourth Mil Med Univ, Dept Math & Phys, Xian 710032, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Air Force
   Medical University
RP Chen, JZ (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Res Ctr Tradit Chinese Med, 169 West Changle Rd, Xian 710032, Peoples R China.
EM zy04310@fmmu.edu.cn; jzchen57@fmmu.edu.cn
OI Zhang, Xiaojun/0000-0002-0304-0003
FU Nature Science Foundation of China [81173590]
FX This work was supported by grants from the Nature Science Foundation of
   China (Project No. 81173590).
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NR 60
TC 87
Z9 101
U1 0
U2 64
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD APR
PY 2015
VL 51
IS 2
BP 718
EP 728
DI 10.1007/s12035-014-8755-0
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA CD7YL
UT WOS:000351311800023
PM 24913834
DA 2026-05-27
ER

PT J
AU Yu, S
   Wei, L
   Chi, XJ
   Xu, H
   Ding, F
AF Yu, Shu
   Wei, Li
   Chi, Xiaojing
   Xu, Hui
   Ding, Fei
TI 2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy--d-pyranoside, an analog of
   salidroside, contributes to neuroprotection in cerebral ischemic injury
   in vitro and in vivo
SO NEUROREPORT
LA English
DT Article
DE apoptosis; blood-brain barrier; cerebral ischemic injury; glucose
   metabolism; 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxy--d-pyranoside;
   pharmacokinetics; salidroside analog
ID APOPTOSIS; STROKE; CELL
AB 2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxyb-d-pyranoside (code-named SalA-4g), an analog of salidroside, has potent neuroprotective effects. In this study, the pharmacological properties of SalA-4g were evaluated in primary cortical neurons exposed to oxygen and glucose deprivation and in a rat model of transient middle cerebral artery occlusion. The results of pharmacokinetic and brain distribution studies indicated that SalA-4g could pass through the blood-brain barrier with a relatively short elimination time. 3-[4,5-Dimethyl-2-thiazolyl]-2,5-diphenyl tetrazolium bromide assay, terminal deoxynucleotidyl transferase dUTP nick-end labeling, and Annexin V staining collectively showed that SalA-4g inhibited neuronal viability loss and apoptosis in a concentration-dependent manner in an oxygen and glucose deprivation model. Fluorine-18-fluorodeoxyglucose PET/CT imaging indicated that SalA-4g improved metabolic recovery in the ischemic hemisphere in a rat middle cerebral artery occlusion model. Our findings provide further evidence of the potential therapeutic applications of SalA-4g for the treatment of cerebral ischemic injury.
C1 [Yu, Shu; Ding, Fei] Soochow Univ, Sch Biol & Basic Med Sci, Suzhou, Peoples R China.
   [Yu, Shu; Wei, Li; Chi, Xiaojing; Xu, Hui; Ding, Fei] Nantong Univ, Key Lab Neuroregenerat Jiangsu, Nantong, Jiangsu, Peoples R China.
   [Yu, Shu; Wei, Li; Chi, Xiaojing; Xu, Hui; Ding, Fei] Nantong Univ, Minist Educ, Coinnovat Ctr Neuroregenerat, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
C3 Soochow University - China; Nantong University; Nantong University
RP Ding, F (corresponding author), Nantong Univ, Minist Educ, Coinnovat Ctr Neuroregenerat, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.; Ding, F (corresponding author), Nantong Univ, Dept Key Lab Neuroregenerat Jiangsu, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
EM dingfei@ntu.edu.cn
RI DING, FEI/KLD-8925-2024
OI Yu, Shu/0000-0003-3771-267X
FU National Key Basic Research Program of China (973 program)
   [2014CB542203]; National Natural Science Foundation of China [81401094,
   81371389]; Priority Academic Program Development of Jiangsu Higher
   Education Institution (PAPD)
FX This work was supported by the National Key Basic Research Program of
   China (973 program, grant no. 2014CB542203), the National Natural
   Science Foundation of China (grant nos 81401094 and 81371389), and a
   project funded by the Priority Academic Program Development of Jiangsu
   Higher Education Institution (PAPD).
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NR 11
TC 5
Z9 5
U1 0
U2 10
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0959-4965
EI 1473-558X
J9 NEUROREPORT
JI Neuroreport
PD MAR 21
PY 2018
VL 29
IS 5
BP 426
EP 431
DI 10.1097/WNR.0000000000000987
PG 6
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GA2UM
UT WOS:000428181100014
PM 29461335
DA 2026-05-27
ER

PT J
AU Xie, YY
   Hou, XL
   Chen, ZH
   Aisa, HA
AF Xie Yu-yu
   Hou Xue-ling
   Chen Zhi-hui
   Aisa Haji Akber
TI Density Functional Theory Studies on Structure and Spectra of
   Salidroside Molecule
SO SPECTROSCOPY AND SPECTRAL ANALYSIS
LA Chinese
DT Article
DE Salidroside; IR; NMR; ESP; Density functional theory
AB At present, with the continuous development of science and technology, more and more new techniques emerge in quality control quality evaluation of Traditional Chinese Medicines (TCMs). In the standardization process of TCMs, modern pharmaceutical research has made many remarkable achievements. Detection methods and technologies have made great progress from single-index detection to multi-index detection. Rhodiola Rosea is a kind of minority nationality medicine that is an indispensable part of the development of traditional Chinese medicine. Salidroside is one of the main components of Rhodiola Rosea. There are many reports on its extraction, separation and purification. However, far few reports have been reported up to now on its molecular parameters, such as bond length, bond angle, dihedral angle, frontier orbital distribution and surface electrostatic charge Distributions, which are critical factors determining its chemical properties and reaction mechanism. The parameters of bond length, bond angle and dihedral angle of salidroside were obtained by DFT / B3LYP method and 6-31 (d) basis set from Gaussian09W software. As the result of optimization, the surface electrostatic charge (ESP), the lowest occupied orbit (LUMO), the highest occupied orbit ( HOMO). Infrared (IR) and nuclear magnetic resonance (NMR) data were calculated, and their peak positions were assigned and compared with the reported data. The results reveal that there is no imaginary frequency in the infrared absorption frequency, which indicates that the optimization result is reasonable and reliable; the highest occupied orbit energy E= - 5. 82 eV, the lowest orbit energy E= - 0. 000 42 eV, and the difference is 5. 81 eV. By drawing the electron cloud distribution map of the orbit, we can see that the HOMO orbit is the pi bonding orbital of electron mainly distributing on the benzene ring with a node ; the LUMO orbit is the pi antibonding orbital of electron mainly distributing on the benzene ring with two nodes. The drawing of surface electrostatic charge can directly determine which part of the molecule is prone to nucleophilic substitution reaction and which is prone to electrophilic reaction. The electron migration direction can be obtained directly by drawing the electron difference between the first excited state and the ground state. The theoretical study of salidroside molecular calculation in this dissertation can provide important references and new ideas for further exploring the chemical reaction mechanism, structural modification and identification of active sites.
C1 [Xie Yu-yu; Hou Xue-ling; Aisa Haji Akber] Chinese Acad Sci, Xinjiang Inst Phys & Chem Technol, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China.
   [Xie Yu-yu; Chen Zhi-hui] Chinese Acad Sci, Xinjiang Inst Phys & Chem Technol, Anal Ctr, Urumqi 830011, Peoples R China.
   [Xie Yu-yu; Aisa Haji Akber] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
C3 Chinese Academy of Sciences; Xinjiang Technical Institute of Physics &
   Chemistry, CAS; Chinese Academy of Sciences; Xinjiang Technical
   Institute of Physics & Chemistry, CAS; Chinese Academy of Sciences;
   University of Chinese Academy of Sciences, CAS
RP Aisa, HA (corresponding author), Chinese Acad Sci, Xinjiang Inst Phys & Chem Technol, Key Lab Plant Resources & Chem Arid Zone, Urumqi 830011, Peoples R China.; Aisa, HA (corresponding author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
EM xieyy@ms.xjb.ac.cn; haji@ms.xjb.ac.cn
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NR 15
TC 0
Z9 0
U1 0
U2 29
PU OFFICE SPECTROSCOPY & SPECTRAL ANALYSIS
PI BEIJING
PA NO 76 COLLAGE SOUTH RD BEIJING, BEIJING 100081, PEOPLES R CHINA
SN 1000-0593
J9 SPECTROSC SPECT ANAL
JI Spectrosc. Spectr. Anal.
PD JUN
PY 2022
VL 42
IS 6
BP 1786
EP 1791
DI 10.3964/j.issn.1000-0593(2022)06-1786-06
PG 6
WC Spectroscopy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Spectroscopy
GA 2U4AT
UT WOS:000823103200021
DA 2026-05-27
ER

PT J
AU Zheng, XY
   Zhang, HW
   Zhang, YH
   Ding, Z
   Huang, ZS
   Li, HR
   Yao, MJ
   Song, WT
   Liu, JX
AF Zheng, Xiaoyu
   Zhang, Hongwei
   Zhang, Yehao
   Ding, Zhao
   Huang, Zishan
   Li, Haoran
   Yao, Mingjiang
   Song, Wenting
   Liu, Jianxun
TI Salidroside ameliorates cerebral ischemic injury and regulates the
   glutamate metabolism pathway in astrocytes
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; cerebral ischemia; astrocyte; glutamate metabolism;
   glutamine synthetase; glutamate transporter 1
ID BRAIN; EXPRESSION; GLT-1
AB Background and Aim Salidroside (SA) is the main active component of Rhodiola rosea L., with potential in treating cardiovascular and cerebrovascular diseases and cerebral ischemia. However, its efficacy and mechanism in cerebral ischemia remain unclear, particularly regarding its effect on glutamate (Glu) metabolism. In this paper, we aimed to investigate the efficacy of SA in treating cerebral ischemia and its pharmacological mechanism.Experimental procedure We studied the effects of SA on SD rats with cerebral ischemia, evaluating neurobehavior, cerebral water content, infarct size, and brain microstructure. We also assessed its impact on glial fibrillary acidic protein (GFAP), glutamine synthetase (GS), and glutamate transporter 1 (GLT-1) proteins using immunohistochemistry and Western blot. Additionally, we used SVGp12 cells to simulate cerebral ischemia and measured Glu levels and used Western blot to observe the level of GS and GLT-1.Results SA improved neural function, reduced infarct size, and regulated GSH and Glu levels in rats. In cell experiments, SA increased cell viability and decreased Glu concentration after ischemia induction. It also regulated the expression of GFAP, GS, and GLT-1.Conclusion SA alleviates cerebral ischemia-induced injury by acting on astrocytes, possibly through regulating the glutamate metabolic pathway.
C1 [Zheng, Xiaoyu; Zhang, Hongwei; Zhang, Yehao; Ding, Zhao; Huang, Zishan; Li, Haoran; Yao, Mingjiang; Song, Wenting; Liu, Jianxun] Chinese Acad Tradit Chinese Med, Xiyuan Hosp, Natl Res Ctr Clin Med Cardiovasc Dis Tradit Chines, Beijing Key Lab Tradit Chinese Med Pharmacol, Beijing, Peoples R China.
   [Zhang, Hongwei] Chinese Acad Tradit Chinese Med, Xiyuan Hosp, Natl Clin Res Ctr Chinese Med Cardiol, Beijing, Peoples R China.
   [Huang, Zishan; Li, Haoran] Guangdong Pharmaceut Univ, Res Inst Tradit Chinese Med, Guangzhou, Peoples R China.
C3 China Academy of Chinese Medical Sciences; Xiyuan Hospital, CACMS; China
   Academy of Chinese Medical Sciences; Xiyuan Hospital, CACMS; Guangdong
   Pharmaceutical University
RP Song, WT; Liu, JX (corresponding author), Chinese Acad Tradit Chinese Med, Xiyuan Hosp, Natl Res Ctr Clin Med Cardiovasc Dis Tradit Chines, Beijing Key Lab Tradit Chinese Med Pharmacol, Beijing, Peoples R China.
EM wenting_song1@163.com; liujx0324@sina.com
RI zhang, yehao/JTT-1044-2023
FU National Natural Science Foundation of China10.13039/501100001809
FX The authors are grateful to Frontiers experts for their helpful
   suggestions.
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NR 45
TC 6
Z9 7
U1 2
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD NOV 12
PY 2024
VL 15
AR 1472100
DI 10.3389/fphar.2024.1472100
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA N2B8C
UT WOS:001362457000001
PM 39600364
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, HL
   Li, QQ
   Sun, SY
   Chen, SD
AF Wang, Hualong
   Li, Qiongqiong
   Sun, Suya
   Chen, Shengdi
TI Neuroprotective Effects of Salidroside in a Mouse Model of Alzheimer's
   Disease
SO CELLULAR AND MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE Alzheimer's disease; Amyloid-beta; Salidroside; Neuroprotection; PI3K;
   Akt
ID AMYLOID PRECURSOR PROTEIN; INDUCED RAT MODEL; COGNITIVE DEFICITS;
   RHODIOLA-ROSEA; BRAIN; EXPRESSION; BEHAVIOR; PATHWAY; NEUROGENESIS;
   ACCUMULATION
AB Alzheimer's disease (AD), the most common form of dementia worldwide, is characterized by pathological hallmarks like beta-amyloid peptide (A beta) and clinical manifestations including cognitive impairment, psychiatry disorders, and behavioral changes. Salidroside (Sal) extracted from Rhodiola rosea L. showed protective effects against A beta-induced neurotoxicity in a Drosophila AD model in our previous research. In the present study, daily doses of Sal were administered to APP/PS1 mice, a mouse model of AD, and several parameters were tested, including behavioral performance, A beta status, levels of synapse-related proteins, and levels of PI3K/Akt targets of mTOR cell signaling pathway proteins. The behavioral testing showed an improvement in locomotor activity in the APP/PS1 mice after the administration of Sal. Treatment with Sal decreased both the soluble and insoluble A beta levels and increased the expression of PSD95, NMDAR1, and calmodulin-dependent protein kinase II. The phosphatidylinositide PI3K/Akt/mTOR signaling was upregulated, which was in accordance with the above improvements from Sal treatment. Our findings suggested that Sal may protect the damaged synapses of the neurons in the APP/PS1 mice.
C1 [Wang, Hualong; Li, Qiongqiong; Sun, Suya; Chen, Shengdi] Shanghai Jiao Tong Univ, Sch Med, Dept Neurol, Ruijin Hosp, Shanghai 200025, Peoples R China.
   [Wang, Hualong] Hebei Med Univ, Dept Neurol, Hosp 1, Shijiazhuang, Hebei, Peoples R China.
   [Wang, Hualong] Brain Aging & Cognit Neurosci Lab Hebei Prov, Shijiazhuang, Hebei, Peoples R China.
C3 Shanghai Jiao Tong University; Hebei Medical University
RP Sun, SY; Chen, SD (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Dept Neurol, Ruijin Hosp, Shanghai 200025, Peoples R China.
EM sunsuya@shsmu.edu.cn; chensd@rjh.com.cn
FU Natural Science Fund of China [91332107]; Innovation Program of Shanghai
   Municipal Education Commission [2017-01-07-00-01-E00046]
FX This work was supported by Grants from the Natural Science Fund of China
   (No. 91332107) and the Innovation Program of Shanghai Municipal
   Education Commission (2017-01-07-00-01-E00046).
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NR 40
TC 49
Z9 57
U1 1
U2 42
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0272-4340
EI 1573-6830
J9 CELL MOL NEUROBIOL
JI Cell. Mol. Neurobiol.
PD OCT
PY 2020
VL 40
IS 7
BP 1133
EP 1142
DI 10.1007/s10571-020-00801-w
EA JAN 2020
PG 10
WC Cell Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Neurosciences & Neurology
GA NA4SR
UT WOS:000510285000001
PM 32002777
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Wang, XL
   Wang, X
   Xiong, LL
   Zhu, Y
   Chen, HL
   Chen, JX
   Wang, XX
   Li, RL
   Guo, ZY
   Li, P
   Jiang, W
AF Wang, Xu-Lei
   Wang, Xue
   Xiong, Li-Li
   Zhu, Ye
   Chen, Hua-Li
   Chen, Jia-Xiang
   Wang, Xiao-Xiao
   Li, Ru-Li
   Guo, Zhi-Yun
   Li, Ping
   Jiang, Wei
TI Salidroside Improves Doxorubicin-induced Cardiac Dysfunction by
   Suppression of Excessive Oxidative Stress and Cardiomyocyte Apoptosis
SO JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
LA English
DT Article
DE salidroside; doxorubicin; ROS; catalase; Mn-SOD; Bcl2/Bax
ID PEROXIDE-INDUCED INJURY; ANTHRACYCLINE CARDIOTOXICITY; H9C2 CELLS;
   ISCHEMIA-REPERFUSION; PROTECTS; INHIBITION; MECHANISMS; EXPRESSION;
   STRATEGIES; FAMILY
AB Doxorubicin (DOX) is a potent available antitumor drug; however, its clinical use is limited by the cardiotoxicity. Salidroside (SLD), with strong antioxidative and cytoprotective actions, is of particular interest in the development of antioxidative therapies for oxidative injury in cardiac diseases. Now, the protection and underlying mechanisms of SLD against DOX-induced cardiotoxicity are still unknown. In the present study, we revealed both antioxidative mechanism and Bcl2-dependent survival signaling involved in SLD's protection. We observed that DOX exposure induced mortality elevation, body weight loss, and cardiac dysfunction in mice, increased lactate dehydrogenase leakage and cardiomyocyte apoptosis, but decreased cell viability and size in cardiac tissues and cultured H9c2 cells, respectively, which were effectively antagonized by SLD supplement. We further observed that SLD significantly reduced the intercellular oxidative stress level, partly by inhibiting NOX1 expression and augmenting the expression and activities of the endogenous antioxidative enzymes, catalase, and manganese superoxide dismutase. In addition, SLD treatment upregulated the antiapoptotic Bcl2 and downregulated the proapoptotic Bax and inhibited a downstream pathway of Bcl2/Bax and caspase-3 activity. Our results indicated that SLD effectively protected the cardiomyocytes against DOX-induced cardiotoxicity by suppressing the excessive oxidative stress and activating a Bcl2-mediated survival signaling pathway.
C1 [Wang, Xu-Lei; Xiong, Li-Li; Guo, Zhi-Yun; Li, Ping] Southwest Jiaotong Univ, Sch Life Sci & Bioengn, Chengdu, Peoples R China.
   [Wang, Xue; Chen, Hua-Li; Chen, Jia-Xiang; Wang, Xiao-Xiao; Li, Ru-Li; Jiang, Wei] Sichuan Univ, Mol Med Res Ctr, State Key Lab Biotherapy, Chengdu 610041, Peoples R China.
   [Zhu, Ye] Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu 610041, Peoples R China.
C3 Southwest Jiaotong University; Sichuan University; Sichuan University
RP Jiang, W (corresponding author), Sichuan Univ, West China Hosp, Mol Med Res Ctr, State Key Lab Biotherapy, Chengdu 610041, Peoples R China.
EM wcumsjw72@hotmail.com
RI Guo, Zhiyun/H-3394-2017; Wang, Xulei/OHR-7477-2025
FU Key Projects in the Science and Technology Pillar Program of Sichuan
   Province [2009FZ0067]; National Natural Science Foundation of China
   [30871017, 31071001, 31271226, 31200999]; Fundamental Research Funds for
   the Central Universities [SWJTU12CX050]
FX Supported by the Key Projects in the Science and Technology Pillar
   Program of Sichuan Province (2009FZ0067 to Dr W. Jiang), the National
   Natural Science Foundation of China (30871017, 31071001, and 31271226 to
   Dr W. Jiang, and 31200999 to Dr L. L. Xiong), and the Fundamental
   Research Funds for the Central Universities (SWJTU12CX050 to Dr Z. Y.
   Guo).
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NR 35
TC 38
Z9 45
U1 0
U2 16
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA 530 WALNUT ST, PHILADELPHIA, PA 19106-3621 USA
SN 0160-2446
EI 1533-4023
J9 J CARDIOVASC PHARM
JI J. Cardiovasc. Pharmacol.
PD DEC
PY 2013
VL 62
IS 6
BP 512
EP 523
DI 10.1097/FJC.0000000000000009
PG 12
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA 274DR
UT WOS:000328586500003
PM 24072175
DA 2026-05-27
ER

PT J
AU Zhu, T
   Li, HQ
   Zheng, ZT
   Wang, T
   Zhou, YX
   Li, MH
   Wu, W
   Peng, XS
   Zhou, YF
AF Zhu, Tong
   Li, Hui-qin
   Zheng, Ze-tai
   Wang, Tao
   Zhou, Yan-xin
   Li, Ming-hua
   Wu, Wei
   Peng, Xin-sheng
   Zhou, Yan-fang
TI Bone marrow mesenchymal stem cells-laden salidroside-collagen hybrid
   scaffold (BMSCs-SCOL) accelerates full-thickness skin wound healing by
   reducing oxidative stress and upregulating transforming growth factor
   beta
SO JOURNAL OF MATERIALS SCIENCE
LA English
DT Article
ID TGF-BETA; HYDROGEL; SPONGE; RATS
AB Oxidative stress is widely recognized as a vital factor in the etiopathogenesis of non-healing wounds. In our study, we propose an effective strategy that combines bone marrow mesenchymal stem cells (BMSCs) with an anti-oxidative scaffold fabricated by integrating salidroside and collagen, namely, the BMSCs-laden salidroside-collagen hybrid scaffold (BMSCs-SCOL). The fabricated SCOL scaffold exhibited suitable porosity, good water vapor transmission rate, successful drug release system, perfect cell adhesion and excellent cell viability for BMSCs. Moreover, the natural anti-oxidative compound salidroside showed in vitro rejuvenation effect on BMSCs by reducing the intracellular reactive oxygen species, increasing the mitochondrial membrane potential, reducing the activity of senescence-associated beta-galactosidase (SA-beta-gal) and downregulating the expressions of senescence-associated proteins, such as P21 and P16 in the D-gal induced model. In addition, the effect of BMSCs-SCOL on non-healing wounds was researched in vivo in Sprague-Dawley (SD) rats induced by full-thickness skin excision. Results showed that BMSCs-SCOL significantly promoted skin wound healing in SD rats, showing more collagen deposition and thinner epidermal thickness. BMSCs-SCOL also reduced the oxidative stress by decreasing malondialdehyde (MDA) content, increasing superoxide dismutase (SOD) activity and upregulating the expressions of collagen type 1 (COL-1), transforming growth factor beta1 (TGF-beta 1) and TGF-beta 3 in the wound tissues of SD rats. Therefore, BMSCs-SCOL represents a promising strategy to accelerate skin wound healing owing to its pronounced anti-oxidative properties and its ability to upregulate TGF-beta expression.
C1 [Zhu, Tong; Li, Hui-qin; Zheng, Ze-tai; Zhou, Yan-fang] Guangdong Med Univ, Dept Pathophysiol, Dongguan 523808, Guangdong, Peoples R China.
   [Wang, Tao; Li, Ming-hua] Guangdong Med Univ, Peoples Hosp Shunde Dist 5, Foshan 528300, Guangdong, Peoples R China.
   [Zhou, Yan-xin] Guangdong Med Univ, Coll Med Technol, Dongguan 523808, Guangdong, Peoples R China.
   [Wu, Wei] Shunde Polytech, Dept Med Sci, Foshan 528300, Guangdong, Peoples R China.
   [Peng, Xin-sheng] Guangdong Med Univ, Sch Pharm, Dongguan 523808, Guangdong, Peoples R China.
   [Peng, Xin-sheng] Guangdong Med Univ, Affiliated Hosp, Zhanjiang 524001, Guangdong, Peoples R China.
C3 Guangdong Medical University; Guangdong Medical University; Guangdong
   Medical University; Shunde Polytechnic University; Guangdong Medical
   University; Guangdong Medical University
RP Zhou, YF (corresponding author), Guangdong Med Univ, Dept Pathophysiol, Dongguan 523808, Guangdong, Peoples R China.; Peng, XS (corresponding author), Guangdong Med Univ, Sch Pharm, Dongguan 523808, Guangdong, Peoples R China.; Peng, XS (corresponding author), Guangdong Med Univ, Affiliated Hosp, Zhanjiang 524001, Guangdong, Peoples R China.
EM ztong37@163.com; lihuiqin@gdmu.edu.cn; mizu990509@163.com;
   job1982@126.com; 84994175@qq.com; 1390728997@qq.com; 40261010@qq.com;
   xspeng@gdmu.edu.cn; yfzhou@gdmu.edu.cn
OI li, hui-qin/0009-0000-6213-7406
FU Guangdong Basic and Applied Basic Research Foundation [2021A1515012437];
   Featured Innovation Projects for General Colleges and Universities of
   Guangdong Province [2021KTSCX040]; Guangdong Provincial Bureau of
   Traditional Chinese Medicine [20231328]; Research project of Guangdong
   Medical University [2001/2XK22029]; Discipline construction project of
   Guangdong Medical University [1019K20220003]
FX This study was carried out with the support of Guangdong Basic and
   Applied Basic Research Foundation (2021A1515012437), Featured Innovation
   Projects for General Colleges and Universities of Guangdong Province
   (2021KTSCX040), Guangdong Provincial Bureau of Traditional Chinese
   Medicine (20231328), Research project of Guangdong Medical University
   (2001/2XK22029) and the Discipline construction project of Guangdong
   Medical University (1019K20220003).
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NR 53
TC 0
Z9 0
U1 6
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0022-2461
EI 1573-4803
J9 J MATER SCI
JI J. Mater. Sci.
PD JAN
PY 2026
VL 61
IS 1
BP 506
EP 525
DI 10.1007/s10853-025-11867-6
EA DEC 2025
PG 20
WC Materials Science, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Materials Science
GA AL6CK
UT WOS:001632369100001
DA 2026-05-27
ER

PT J
AU Fan, YB
   Wang, W
   Tian, LQ
   Yin, J
AF Fan, Yanbo
   Wang, Wei
   Tian, Liqun
   Yin, Jie
TI Salidroside induced repair of myocardial infarction through Nrf2/HO-1
SO BRAZILIAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Fibrosis; HO-1; Myocardial Infarction; Salidroside; PI3K; Akt
ID CELLS
AB Salidroside (SAL) has been confirmed to have some protective effects against inflammatory injury. However, little information was established as to the mechanism of these protective effects. To this effect, we designed this study to explore the protective effects and mechanisms of SAL against myocardial infarction (MI). A rat MI model was established and divided into five groups (n = 6): sham, MI, MI+SAL, MI+ LY294002 (PI3K inhibitor), and MI+SAL+ LY294002. The cardiac function and histological pathology were analyzed with a color Doppler ultrasonic diagnostic instrument. Anti-oxidative enzyme activities and the production of inflammatory media were assayed by biochemical kits and ELISA. MI size and fibrosis were assayed by Masson???s trichrome staining while Bax/Bcl-2 and PI3K/Akt/Nrf2/HO-1 were assayed by Western blotting and immunofluorescence. The results showed that SAL significantly improved the left ventricle ejection fraction and fractional shortening, decreased the MI size and fibrosis, inhibited apoptosis and promoted blood vessel formation. SAL promoted anti-oxidative and anti-inflammatory abilities. Moreover, SAL enhanced PI3K/ Akt/Nrf2/HO-1 expression. To this effect, we designed this study suggested that SAL induced repair of MI via PI3K/A kt/ Nrf2/HO-1.
C1 [Fan, Yanbo; Wang, Wei; Tian, Liqun] Wuhan Hosp Thadit Chinese Med, Dept Cardiol, Wuhan 430014, Hubei, Peoples R China.
   [Yin, Jie] Hubei Univ Chinese Med, Dept Cardiol, Wuhan 430065, Hubei, Peoples R China.
C3 Hubei University of Chinese Medicine
RP Yin, J (corresponding author), Hubei Univ Chinese Med, Dept Cardiol, Wuhan 430065, Hubei, Peoples R China.
EM fanyanbo66@outlook.com
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NR 17
TC 1
Z9 1
U1 0
U2 7
PU UNIV SAO PAULO, CONJUNTO QUIMICAS
PI SAO PAULO
PA SERVICO PUBLICACOES E CIRCULACAO, CAIXA POSTAL 66083, SAO PAULO, 00000,
   BRAZIL
SN 1984-8250
EI 2175-9790
J9 BRAZ J PHARM SCI
JI Braz. J. Pharm. Sci.
PY 2022
VL 58
AR e20218
DI 10.1590/s2175-97902022e20218
PG 9
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6F0PN
UT WOS:000883772500001
OA Green Submitted, Green Published, gold
DA 2026-05-27
ER

PT J
AU Wu, YC
   Lian, YZ
   Zhao, HW
   Wang, L
   Ning, DS
   Chao, JCJ
AF Wu, Yung-Chun
   Lian, Yu Zhi
   Zhao, Hongwei
   Wang, Lei
   Ning, Deshan
   Chao, Jane C. -J.
TI Ginsenosides, salidroside, and syringin complex exhibits anti-fatigue in
   exhaustive exercise rats
SO INTERNATIONAL JOURNAL OF MEDICAL SCIENCES
LA English
DT Article
DE Chinese herb; exercise performance; lactate clearance; antioxidation;
   anti-inflammation; rats
ID INDUCED OXIDATIVE STRESS; LIVER; SUPPLEMENTATION; ENDURANCE; DAMAGE;
   MODEL
AB Excessive exercise can lead to fatigue, consequently affect exercise performance, and further have an adverse impact to human health. The synergistic effects of ginsenosides, salidroside, and syringin on improving exercise performance remain unknown. Hence, the effects of Chinese herb powder (CHP) which consisted of bioactive compounds such as ginsenosides (Rg1, Re, and Rb1), salidroside, and syringin on exercise performance, energy metabolism, tissue damage, antioxidant activity, and inflammatory cytokine were investigated in exhaustive exercise rats. Male Sprague-Dawley rats aged of 8-week-old were randomly assigned into four groups: control (normal, N), low-dose (L, 310 mg/kg bw), medium-dose (M, 620 mg/kg bw), and high-dose (H, 1550 mg/kg bw) groups. The intervention groups were orally given CHP daily for successive 30 days. Abdominal arterial blood, liver, and gastrocnemius muscles were collected 4 hours after exhaustive exercise for further analysis. The high-dose CHP group increased the time to exhaustion, decreased serum lactate level, increased serum superoxide dismutase activity, and decreased liver interleukin-6 concentration. Therefore, CHP exhibits an anti-fatigue effect for prolonging the time to exhaustion through improving lactate clearance, and to a lesser extent, enhancing the capacity of antioxidation and anti-inflammation.
C1 [Wu, Yung-Chun; Lian, Yu Zhi; Chao, Jane C. -J.] Taipei Med Univ, Sch Nutr & Hlth Sci, 50 Wu-Hsing St, Taipei 110, Taiwan.
   [Zhao, Hongwei; Wang, Lei; Ning, Deshan] Infinitus China Co Ltd, 6F,Tower,Infinitus Plaza,1 Yuncheng South 1st Rd, Guangzhou 510405, Peoples R China.
   [Chao, Jane C. -J.] Taipei Med Univ, Master Program Global Hlth & Hlth Secur, Taipei 110, Taiwan.
   [Chao, Jane C. -J.] Taipei Med Univ, TMU Res Ctr Digest Med, Taipei 110, Taiwan.
   [Chao, Jane C. -J.] Taipei Med Univ Hosp, Nutr Res Ctr, Taipei 110, Taiwan.
C3 Taipei Medical University; Taipei Medical University; Taipei Medical
   University; Taipei Medical University; Taipei Medical University
   Hospital
RP Chao, JCJ (corresponding author), Taipei Med Univ, Sch Nutr & Hlth Sci, 50 Wu-Hsing St, Taipei 110, Taiwan.; Ning, DS (corresponding author), Infinitus China Co Ltd, 6F,Tower,Infinitus Plaza,1 Yuncheng South 1st Rd, Guangzhou 510405, Peoples R China.
EM Sam.Ning@infinitus-int.com; chenjui@tmu.edu.tw
FU Infinitus (China) Co. Ltd. (Guangzhou, China) [A-110-027]
FX The work was supported by Infinitus (China) Co. Ltd. (Guangzhou, China)
   (grant no. A-110-027) .
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NR 50
TC 7
Z9 7
U1 5
U2 21
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1449-1907
J9 INT J MED SCI
JI Int. J. Med. Sci.
PY 2025
VL 22
IS 1
BP 17
EP 26
DI 10.7150/ijms.99889
PG 10
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA X0N5E
UT WOS:001422425100002
PM 39744162
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhou, PN
   Dang, JJ
   Jiang, Z
   Dai, SL
   Qu, C
   Wu, QA
AF Zhou, Peina
   Dang, Jingjie
   Jiang, Zheng
   Dai, Shilin
   Qu, Cheng
   Wu, Qinan
TI Transcriptome and metabolome analysis revealed the dynamic change of
   bioactive compounds of Fructus Ligustri Lucidi
SO BMC PLANT BIOLOGY
LA English
DT Article
DE Fructus Ligustri Lucidi; Metabolome; Transcriptome; Secoiridoid
   biosynthesis; Salidroside biosynthesis
ID IDENTIFICATION; BIOSYNTHESIS; OLEUROPEIN
AB Background The Fructus Ligustri Lucidi, the fruit of Ligustrum lucidum, contains a variety of bioactive compounds, such as flavonoids, triterpenoids, and secoiridoids. The proportions of these compounds vary greatly during the different fruit development periods of Fructus Ligustri Lucidi. However, a clear understanding of how the proportions of the compounds and their regulatory biosynthetic mechanisms change across the different fruit development periods of Fructus Ligustri Lucidi is still lacking.Results In this study, metabolite profiling and transcriptome analysis of six fruit development periods (45 DAF, 75 DAF, 112 DAF, 135 DAF, 170 DAF, and 195 DAF) were performed. Seventy compounds were tentatively identified, of which secoiridoids were the most abundant. Eleven identified compounds were quantified by high performance liquid chromatography. A total of 103,058 unigenes were obtained from six periods of Fructus Ligustri Lucidi. Furthermore, candidate genes involved in triterpenoids, phenylethanols, and oleoside-type secoiridoid biosynthesis were identified and analyzed. The in vitro enzyme activities of nine glycosyltransferases involved in salidroside biosynthesis revealed that they can catalyze trysol and hydroxytyrosol to salidroside and hydroxylsalidroside.Conclusions These results provide valuable information to clarify the profile and molecular regulatory mechanisms of metabolite biosynthesis, and also in optimizing the harvest time of this fruit.
C1 [Zhou, Peina; Dang, Jingjie; Jiang, Zheng; Dai, Shilin; Qu, Cheng; Wu, Qinan] Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Peoples R China.
   [Zhou, Peina; Dang, Jingjie; Jiang, Zheng; Dai, Shilin; Qu, Cheng; Wu, Qinan] Collaborat Innovat Ctr Chinese Med Resources Indus, Nanjing 210023, Peoples R China.
   [Wu, Qinan] Natl & Local Collaborat Engn Ctr Chinese Med Resou, Nanjing 210023, Peoples R China.
C3 Nanjing University of Chinese Medicine
RP Qu, C; Wu, QA (corresponding author), Nanjing Univ Chinese Med, Coll Pharm, Nanjing 210023, Peoples R China.; Qu, C; Wu, QA (corresponding author), Collaborat Innovat Ctr Chinese Med Resources Indus, Nanjing 210023, Peoples R China.; Wu, QA (corresponding author), Natl & Local Collaborat Engn Ctr Chinese Med Resou, Nanjing 210023, Peoples R China.
EM qucheng@njucm.edu.cn; wuqn@njucm.edu.cn
RI Wu, Qinan/ACT-0899-2022; Zhou, Peina/KZU-3088-2024
OI Zhou, Peina/0000-0002-5475-3863
FU National Natural Science Foundation of China
FX Not applicable.
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NR 26
TC 6
Z9 6
U1 2
U2 21
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1471-2229
J9 BMC PLANT BIOL
JI BMC Plant Biol.
PD JUN 3
PY 2024
VL 24
IS 1
AR 489
DI 10.1186/s12870-024-05096-3
PG 16
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA SX0D7
UT WOS:001237620000004
PM 38825671
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Almohawes, ZN
   El-Kott, A
   Morsy, K
   Shati, AA
   El-Kenawy, AE
   Khalifa, HS
   Elsaid, FG
   Abd-Lateif, AM
   Abu-Zaiton, A
   Ebealy, ER
   Abdel-Daim, MM
   Ghanem, RA
   Abd-Ella, EM
AF Almohawes, Zakiah N.
   El-Kott, Attalla
   Morsy, Kareem
   Shati, Ali A.
   El-Kenawy, Ayman E.
   Khalifa, Heba S.
   Elsaid, Fahmy G.
   Abd-Lateif, Abd-El-Karim M.
   Abu-Zaiton, Ahmed
   Ebealy, Eman R.
   Abdel-Daim, Mohamed M.
   Ghanem, Reham A.
   Abd-Ella, Eman M.
TI Salidroside inhibits insulin resistance and hepatic steatosis by
   downregulating miR-21 and subsequent activation of AMPK and upregulation
   of PPARα in the liver and muscles of high fat diet-fed rats
SO ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE HFD; NAFLD; insulin resistance; miR-21; salidroside; SREBPs; steatosis;
   rats
ID OXIDATIVE STRESS; MOLECULAR-MECHANISM; SIGNALING PATHWAY;
   LIPID-METABOLISM; GENE-EXPRESSION; RECEPTOR-ALPHA; DISEASE; MICRORNA-21;
   PATHOGENESIS; HEPATOCYTES
AB This study evaluated if salidroside (SAL) alleviates high-fat diet (HFD)-induced non-alcoholic fatty liver disease (NAFLD) by downregulating miR-21. Rats (n = 8/group) were treated for 12 weeks as normal diet (control/ND), ND + agmoir negative control (NC) (150 mu g/kg), ND + SAL (300 mg/kg), HFD, HFD + SAL, HFD + compound C (an AMPK inhibitor) (200 ng/kg), HFD + SAL + NXT629 (a PPAR-alpha antagonist) (30 mg/kg), and HFD + SAL + miR-21 agomir (150 mu g/kg). SAL improved glucose and insulin tolerance and preserved livers in HFD-fed rats. In ND and HFD-fed rats, SAL reduced levels of serum and hepatic lipids and the hepatic expression of SREBP1, SREBP2, fatty acid (FA) synthase, and HMGCOAR. It also activated hepatic Nrf2 and increased hepatic/muscular activity of AMPK and levels of PPAR alpha. All effects afforded by SAL were prevented by CC, NXT629, and miR-21 agmoir. In conclusion, activation of AMPK and upregulation of PPAR alpha mediate the anti-steatotic effect of SAL.
C1 [Almohawes, Zakiah N.] Princess Nourah Bint Abdulrahman Univ, Biol Dept, Coll Sci, Riyadh, Saudi Arabia.
   [El-Kott, Attalla; Morsy, Kareem; Shati, Ali A.; Ebealy, Eman R.] King Khalid Univ, Biol Dept, Coll Sci, Abha, Saudi Arabia.
   [El-Kott, Attalla; Khalifa, Heba S.] Damanhour Univ, Zool Dept, Coll Sci, Damanhour, Egypt.
   [Morsy, Kareem] Cairo Univ, Zool Dept, Coll Sci, Cairo, Egypt.
   [El-Kenawy, Ayman E.] Taif Univ, Pathol Dept, Coll Med, At Taif, Saudi Arabia.
   [Elsaid, Fahmy G.] Mansoura Univ, Zool Dept, Fac Sci, Mansoura, Egypt.
   [Abd-Lateif, Abd-El-Karim M.; Abd-Ella, Eman M.] Fayoum Univ, Zool Dept, Coll Sci, Al Fayyum, Egypt.
   [Abu-Zaiton, Ahmed] Al al Bayt Univ, Biol Dept, Almafraq, Jordan.
   [Abdel-Daim, Mohamed M.] Batterjee Med Coll, Pharmaceut Sci Dept, Pharm Program, Jeddah, Saudi Arabia.
   [Abdel-Daim, Mohamed M.] Suez Canal Univ, Pharmacol Dept, Fac Vet Med, Ismailia, Egypt.
   [Ghanem, Reham A.] Delta Univ Sci & Technol, Fac Oral & Dent Med, Oral Biol Dept, Gamasa, Egypt.
   [Abd-Ella, Eman M.] Al Baha Univ, Coll Sci & Art, Biol Dept, Al Mandaq, Saudi Arabia.
C3 Princess Nourah bint Abdulrahman University; King Khalid University;
   Egyptian Knowledge Bank (EKB); Damanhour University; Egyptian Knowledge
   Bank (EKB); Cairo University; Taif University; Egyptian Knowledge Bank
   (EKB); Mansoura University; Egyptian Knowledge Bank (EKB); Fayoum
   University; Al al-Bayt University; Batterjee Medical College; Egyptian
   Knowledge Bank (EKB); Suez Canal University; Delta University for
   Science & Technology; Al Baha University
RP El-Kott, A (corresponding author), King Khalid Univ, Biol Dept, Coll Sci, Abha, Saudi Arabia.
EM elkottaf@yahoo.com
RI ; El-kott, Attalla/D-1971-2017; Elbealy, Eman/HGA-3375-2022; Abdel-Daim,
   Mohamed/B-2545-2013; Elsaid, Fahmy/I-3125-2014; Abu-zaiton,
   Ahmed/AAE-5616-2019; Almohawes, Zakiah/GVU-5852-2022; Morsy,
   Kareem/O-7820-2017; Shati, Ali/J-8491-2012
OI Khalifa, Heba/0000-0003-4351-336X; El-kott, Attalla/0000-0001-5060-0790;
   Elbealy, Eman/0000-0001-6196-5840; Ghanem, Reham/0009-0001-8970-1465;
   Abdel-Daim, Mohamed/0000-0002-4341-2713; Elsaid,
   Fahmy/0000-0002-7754-2524; Abu-zaiton, Ahmed/0000-0003-1677-4927; 
FU Taif University, Saudi Arabia [TURSP-2020/99]; King Khalid University,
   Abha, KSA [R.G.P0.1/62/42]
FX This work was supported by the Taif University Researchers Supporting
   Program (Project number: TURSP-2020/99), Taif University, Saudi Arabia.
   The authors would like to thank the Deanship of Scientific Research at
   King Khalid University, Abha, KSA for funding this work under Grant
   number (R.G.P0.1/62/42).
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NR 90
TC 23
Z9 25
U1 0
U2 41
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1381-3455
EI 1744-4160
J9 ARCH PHYSIOL BIOCHEM
JI Arch. Physiol. Biochem.
PD MAY 3
PY 2024
VL 130
IS 3
BP 257
EP 274
DI 10.1080/13813455.2021.2024578
EA JAN 2022
PG 18
WC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics; Endocrinology &
   Metabolism; Physiology
GA SE6X6
UT WOS:000745344200001
PM 35061559
DA 2026-05-27
ER

PT J
AU Fang, DL
   Chen, Y
   Xu, B
   Ren, K
   He, ZY
   He, LL
   Lei, Y
   Fan, CM
   Song, XR
AF Fang, Dai-Long
   Chen, Yan
   Xu, Bei
   Ren, Ke
   He, Zhi-Yao
   He, Li-Li
   Lei, Yi
   Fan, Chun-Mei
   Song, Xiang-Rong
TI Development of Lipid-Shell and Polymer Core Nanoparticles with
   Water-Soluble Salidroside for Anti-Cancer Therapy
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE salidroside; lipid-shell and polymer-core nanoparticles (LPNPs); PLGA;
   antitumor
ID PLGA NANOPARTICLES; PHYSICOCHEMICAL PROPERTIES; CONTROLLED-RELEASE;
   LOADED PLGA; H9C2 CELLS; IN-VITRO; BLOCK; PEG; APOPTOSIS; MICELLES
AB Salidroside (Sal) is a potent antitumor drug with high water-solubility. The clinic application of Sal in cancer therapy has been significantly restricted by poor oral absorption and low tumor cell uptake. To solve this problem, lipid-shell and polymer-core nanoparticles (Sal-LPNPs) loaded with Sal were developed by a double emulsification method. The processing parameters including the polymer types, organic phase, PVA types and amount were systemically investigated. The obtained optimal Sal-LPNPs, composed of PLGA-PEG-PLGA triblock copolymers and lipids, had high entrapment efficiency (65%), submicron size (150 nm) and negatively charged surface (-23 mV). DSC analysis demonstrated the successful encapsulation of Sal into LPNPs. The core-shell structure of Sal-LPNPs was verified by TEM. Sal released slowly from the LPNPs without apparent burst release. MTT assay revealed that 4T1 and PANC-1 cancer cell lines were sensitive to Sal treatment. Sal-LPNPs had significantly higher antitumor activities than free Sal in 4T1 and PANC-1 cells. The data indicate that LPNPs are a promising Sal vehicle for anti-cancer therapy and worthy of further investigation.
C1 [Fang, Dai-Long; Chen, Yan; Xu, Bei; He, Zhi-Yao; Lei, Yi; Fan, Chun-Mei; Song, Xiang-Rong] Sichuan Univ, State Key Lab Biotherapy, West China Hosp, Chengdu 610041, Sichuan, Peoples R China.
   [Ren, Ke] Univ Nebraska Med Ctr, Dept Pharmaceut Sci, Omaha, NE 68198 USA.
   [He, Li-Li] Southwest Univ Nationalities, Coll Chem & Environm Protect Engn, Chengdu 610041, Sichuan, Peoples R China.
C3 Sichuan University; University of Nebraska System; University of
   Nebraska Medical Center; Southwest Minzu University
RP Song, XR (corresponding author), Sichuan Univ, State Key Lab Biotherapy, West China Hosp, Chengdu 610041, Sichuan, Peoples R China.
EM fangdailongtwozero@126.com; yanzai1112@sina.com; xb1990625@126.com;
   renkemallee@gmail.com; heyaode@163.com; lilihes@163.com;
   13981836037@139.com; fanchunmeiok@163.com; songxr@scu.edu.cn
RI He, Zhi-Yao/ABE-3388-2021; /E-1252-2016
OI He, Zhi-Yao/0000-0001-7888-211X; Chen, Yan/0000-0003-1027-6054; 
FU National Natural Science Foundation of China [81302729, 81273471]; Major
   National S&T Program of China [2013ZX09301304-004]; Fundamental Research
   Funds for the Central Universities [2013SCU04A19]
FX This research has been received financial support from the National
   Natural Science Foundation of China (No. 81302729 and 81273471), the
   Major National S&T Program of China (No. 2013ZX09301304-004) and the
   Fundamental Research Funds for the Central Universities (No.
   2013SCU04A19).
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NR 46
TC 78
Z9 87
U1 0
U2 80
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2014
VL 15
IS 3
BP 3373
EP 3388
DI 10.3390/ijms15033373
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA AF0ZU
UT WOS:000334444700002
PM 24573250
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Jaskólski, M
   Paczkowska-Walendowska, M
   Rybarczyk, Z
   Rosiak, N
   Miklaszewski, A
   Cielecka-Piontek, J
AF Jaskolski, Maciej
   Paczkowska-Walendowska, Magdalena
   Rybarczyk, Zuzanna
   Rosiak, Natalia
   Miklaszewski, Andrzej
   Cielecka-Piontek, Judyta
TI Cyclodextrin/PVP-Based Nanofibers with Rhadiola rosea Extract as
   a New System for Increasing Bioavailability of Active Components
SO MOLECULES
LA English
DT Article
DE <italic>Rhodiola rosea</italic>; electrospun nanofibers; cyclodextrins;
   polyvinylpyrrolidone; bioavailability; salidroside; rosarin
AB The present study aimed to optimize the extraction process for Rhodiola rosea root, then develop and optimize electrospun nanofiber systems containing extract to enhance the bioavailability of its active compounds, salidroside and rosarin. Using a Design of Experiments (DoE) approach, nanofibers were prepared with varying ratios of polyvinylpyrrolidone (PVP) and hydroxypropyl-cyclodextrins (HP alpha CD, HP beta CD, HP gamma CD). The systems were comprehensively characterized in terms of morphology, content of active compounds, dissolution rate, permeability, mucoadhesion, antioxidant, and anti-inflammatory activities. The results showed that nanofiber formulations significantly improved the dissolution and permeability of salidroside and rosarin compared to the crude extract. The antioxidant properties were notably enhanced, while the anti-inflammatory activity varied depending on composition. The formulation containing 3 g HP beta CD and 2.5 g PVP demonstrated the most favorable balance of functional and technological properties. Principal Component Analysis (PCA) and correlation matrix analysis confirmed that system composition strongly influenced the interrelationships between technological parameters and bioactivity. These findings indicate that electrospun nanofibers based on cyclodextrin-PVP matrices are a promising preclinical strategy for improving the delivery of Rhodiola rosea bioactives.
C1 [Jaskolski, Maciej; Paczkowska-Walendowska, Magdalena; Rybarczyk, Zuzanna; Rosiak, Natalia; Cielecka-Piontek, Judyta] Poznan Univ Med Sci, Dept Pharmacognosy & Biomat, Rokietnicka 3, PL-60806 Poznan, Poland.
   [Miklaszewski, Andrzej] Poznan Univ Tech, Inst Mat Sci & Engn, Fac Mech Engn & Management, PL-60965 Poznan, Poland.
C3 Poznan University of Medical Sciences; Poznan University of Technology
RP Paczkowska-Walendowska, M (corresponding author), Poznan Univ Med Sci, Dept Pharmacognosy & Biomat, Rokietnicka 3, PL-60806 Poznan, Poland.
EM jaskolski.mj@gmail.com; mpaczkowska@ump.edu.pl;
   rybarczyk.zuzanna@gmail.com; nrosiak@ump.edu.pl;
   andrzej.miklaszewski@put.poznan.pl; jpiontek@ump.edu.pl
RI Rosiak, Natalia/KFR-7069-2024; Miklaszewski, Andrzej/H-4120-2012;
   Paczkowska, Magdalena/MGU-8055-2025; Jaskolski, Maciej/POU-5222-2026
OI Rosiak, Natalia/0000-0003-4722-6413; Paczkowska-Walendowska,
   Magdalena/0000-0002-0418-9336; Cielecka-Piontek,
   Judyta/0000-0003-0891-5419; Miklaszewski, Andrzej/0000-0001-6792-4281; 
FU National Science Center (Poland) under the Sonata grant; Ministry of
   Science and Higher Education in Poland [0513/SBAD/4828]; 
   [2020/39/D/NZ7/01824]
FX This research was funded by the National Science Center (Poland) under
   the Sonata grant (number 2020/39/D/NZ7/01824). Andrzej Miklaszewski
   wishes to acknowledge the funding support received from the Ministry of
   Science and Higher Education in Poland, executed under No.
   0513/SBAD/4828.
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NR 31
TC 3
Z9 3
U1 1
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD AUG 13
PY 2025
VL 30
IS 16
AR 3359
DI 10.3390/molecules30163359
PG 26
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 6OF0V
UT WOS:001558044200001
PM 40871512
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Qu, BZ
   Liu, XM
   Liang, YJ
   Zheng, KK
   Zhang, CL
   Lu, LL
AF Qu, Baozhen
   Liu, Xuemao
   Liang, Yanjiao
   Zheng, Keke
   Zhang, Chunling
   Lu, Linlin
TI Salidroside in the Treatment of NAFLD/NASH
SO CHEMISTRY & BIODIVERSITY
LA English
DT Review
DE NAFLD; NASH; salidroside; liver; lipid metabolism
ID NONALCOHOLIC FATTY LIVER; ENDOPLASMIC-RETICULUM STRESS; NF-KAPPA-B;
   OXIDATIVE STRESS; TGF-BETA; AMERICAN ASSOCIATION; INSULIN-RESISTANCE;
   TARGET GENES; CELL-DEATH; IN-VITRO
AB Non-alcoholic fatty liver disease (NAFLD) is the commonest reason for chronic liver diseases in the world and is commonly related to the hepatic manifestation of the metabolic syndrome. Non-alcoholic steatohepatitis (NASH) is a deteriorating form of NAFLD, which can eventually develop into fibrosis, cirrhosis, and liver cancer. The reason for NAFLD/NASH development is complicated, such as liver lipid metabolism, oxidative stress, inflammatory response, apoptosis and autophagy, liver fibrosis and gut microbiota. Apart from bariatric surgery and lifestyle changes, officially approved drug therapy for NAFLD/NASH treatment is lacking. Salidroside (SDS) is a phenolic compound extensively distributed in the tubers of Rhodiola plants, which possesses many significant biological activities. This review summarized the related targets regulated by SDS in treating NAFLD/NASH. It is indicated that SDS could improve the status of NAFLD/NASH by ameliorating abnormal lipid metabolism, inhibiting oxidative stress, regulating apoptosis and autophagy, reducing inflammatory response, alleviating fibrosis and regulating gut microbiota. In conclusion, although the multiple bioactivities of SDS have been confirmed, the clinical data are inadequate and need to become the focus of attention in the later study.
C1 [Qu, Baozhen; Liu, Xuemao; Zhang, Chunling; Lu, Linlin] Qingdao Univ, Qingdao Canc Prevent & Treatment Res Inst, Qingdao Cent Hosp, Affiliated Hosp 2,Med Coll, 127 Siliunan Rd, Qingdao 266042, Peoples R China.
   [Liang, Yanjiao; Zheng, Keke] Qingdao Univ, Dept Oncol Ctr, Qingdao Cent Hosp, Affiliated Hosp 2,Med Coll, Qingdao 266042, Shandong, Peoples R China.
C3 Qingdao University; Qingdao University
RP Zhang, CL; Lu, LL (corresponding author), Qingdao Univ, Qingdao Canc Prevent & Treatment Res Inst, Qingdao Cent Hosp, Affiliated Hosp 2,Med Coll, 127 Siliunan Rd, Qingdao 266042, Peoples R China.
EM lulinlin2007@hotmail.com; qdzcl2011@163.com
OI liu, xuemao/0009-0006-9736-5314; Lu, Linlin/0000-0002-2062-4887
FU National Natural Science Foundation of China [31800660]
FX This work was supported by National Natural Science Foundation of China
   (grant number 31800660).
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NR 164
TC 22
Z9 27
U1 2
U2 65
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1612-1872
EI 1612-1880
J9 CHEM BIODIVERS
JI Chem. Biodivers.
PD DEC
PY 2022
VL 19
IS 12
DI 10.1002/cbdv.202200401
EA NOV 2022
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 8I6QJ
UT WOS:000883115500001
PM 36210339
DA 2026-05-27
ER

PT J
AU Yang, RN
   Yan, C
   Zhou, YF
   Li, WY
   Wang, GX
   Li, H
   Lin, F
   Hao, GL
AF Yang, Ruoning
   Yan, Chi
   Zhou, Yifeng
   Li, Wenyuan
   Wang, Gongxin
   Li, Huan
   Lin, Fei
   Hao, Guoliang
TI Salidroside ameliorates abnormalities in electrophysiological indices
   induced by perfusion of the heart with low-potassium solutions
SO FRONTIERS IN CARDIOVASCULAR MEDICINE
LA English
DT Article
DE hypokalaemia; salidroside; transcriptomic analysis; cardiac
   electrophysiology; arrhythmia
ID HYPOKALEMIA; CHANNEL; RISK
AB Malignant arrhythmias related to hypokalemia are a key risk factor for cardiac arrest, but the specific mechanism remains unclear. In this study, using electrophysiological mapping and transcriptomics techniques, the effects of hypokalemia and paclitaxel (SAL) on isolated rat hearts were investigated. Hypokalemia (3.5-2.0 mmol/L) dose-dependently triggered abnormal arrhythmias and increased the incidence of arrhythmias, while SAL (5 ug/ml) improved this situation. Transcriptomics revealed that hypokalemia upregulated Mt-nd6 and disrupted the inflammatory/immune pathways, while SAL reversed these changes and activated PPAR-related genes. SAL improves the electrophysiological abnormalities caused by hypokalemia by regulating inflammation, immunity and energy metabolism, and has the potential to treat related arrhythmias.
C1 [Yang, Ruoning; Yan, Chi; Zhou, Yifeng; Li, Wenyuan; Wang, Gongxin; Li, Huan; Lin, Fei; Hao, Guoliang] Xinxiang Med Univ, Affiliated Hosp 1, Dept Cardiol, Xinxiang, Henan, Peoples R China.
   [Yang, Ruoning; Yan, Chi; Zhou, Yifeng; Li, Wenyuan; Wang, Gongxin; Li, Huan; Lin, Fei; Hao, Guoliang] Xinxiang Med Univ, Henan Engn Res Ctr Clin Treatment Coronary Heart D, Affiliated Hosp 1, Xinxiang, Peoples R China.
   [Yang, Ruoning; Yan, Chi; Zhou, Yifeng; Li, Wenyuan; Wang, Gongxin; Li, Huan; Lin, Fei; Hao, Guoliang] Xinxiang Med Univ, Affiliated Hosp 1, Henan Joint Int Res Lab Cardiovasc Injury & Repair, Xinxiang, Peoples R China.
   [Wang, Gongxin; Hao, Guoliang] Scope Res Inst Electrophysiol, Dept Res, Kaifeng, Henan, Peoples R China.
C3 Henan Medical University; Henan Medical University; Henan Medical
   University
RP Lin, F; Hao, GL (corresponding author), Xinxiang Med Univ, Affiliated Hosp 1, Dept Cardiol, Xinxiang, Henan, Peoples R China.; Lin, F; Hao, GL (corresponding author), Xinxiang Med Univ, Henan Engn Res Ctr Clin Treatment Coronary Heart D, Affiliated Hosp 1, Xinxiang, Peoples R China.; Lin, F; Hao, GL (corresponding author), Xinxiang Med Univ, Affiliated Hosp 1, Henan Joint Int Res Lab Cardiovasc Injury & Repair, Xinxiang, Peoples R China.; Hao, GL (corresponding author), Scope Res Inst Electrophysiol, Dept Res, Kaifeng, Henan, Peoples R China.
EM 1fy2015157@xxmu.edu.cn; guoliang.hao@epscopelab.com
RI 杨, 若凝/AAT-3209-2020
OI , Chi Yan/0009-0001-4025-0077
FU Science and Technology Department of Henan
FX We would like to thank every teacher in the hospital for their guidance
   and AJE (https://www.aje.cn) for English language editing.
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NR 38
TC 0
Z9 0
U1 1
U2 1
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2297-055X
J9 FRONT CARDIOVASC MED
JI Front. Cardiovasc. Med.
PD AUG 12
PY 2025
VL 12
AR 1628940
DI 10.3389/fcvm.2025.1628940
PG 18
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA 6LQ6Y
UT WOS:001556308100001
PM 40873624
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liao, Q
   Wang, YH
   Huang, R
   Deng, AL
   Xu, H
   Guo, W
   Wen, D
   Xia, TQ
   Bian, JJ
   Xu, ZM
   Zhou, CY
AF Liao, Qing
   Wang, Yihua
   Huang, Rong
   Deng, Ailu
   Xu, Han
   Guo, Wen
   Wen, Dan
   Xia, Tianqin
   Bian, Jiaojiao
   Xu, Zhengmin
   Zhou, Chunyang
TI Salidroside targeted cytosolic phospholipase A2 and regulated
   arachidonic acid metabolomics to attenuate atherosclerosis progression
SO ALL LIFE
LA English
DT Article
DE Salidroside; atherosclerosis; cPLA2; arachidonic acid
AB Lipid metabolism disturbances are linked to the development of atherosclerosis (AS), with arachidonic acid (AA) and other downstream metabolites being involved. Cytosolic phospholipase A2 (cPLA2) is a key restriction enzyme in AA metabolism. Salidroside (SAL) reportedly alleviates AS by inhibiting inflammation and slowing cholesterol accumulation; however, its pharmacological action on lipid metabolism remains unclear. We investigated the effects of SAL on AA metabolism and its interaction with cPLA2 in in vivo and in vitro AS models. SAL inhibited lipid accumulation and atherosclerotic plaque formation, reduced M1 macrophage enrichment in the aortic arch, and decreased cPLA2 expression in both models. Interestingly, the prediction and molecular dynamics (MD) analysis of small molecules indicated that SAL may bind to the cPLA2 protein with high affinity, enhancing its stability and flexibility, and inhibiting its activity. The AA metabolome was disordered in PBS-treated AS mice; with 27 metabolites being significantly different from those in SAL-treated mice, including 15-HETE produced by 15-Lox-2. Moreover, knockdown of 15-Lox-2 in macrophages increased lipid accumulation and cPLA2 expression, which were inhibited by SAL. In summary, SAL affects AS by regulating the disordered metabolism of AA in AS, directly binding to cPLA2, and modulating the function of downstream enzymes of AA.
C1 [Liao, Qing; Wang, Yihua; Huang, Rong; Deng, Ailu; Xu, Han; Guo, Wen; Bian, Jiaojiao; Xu, Zhengmin; Zhou, Chunyang] North Sichuan Med Coll, Inst Mat Med, 234 Fujiang Rd, Nanchong 637000, Sichuan, Peoples R China.
   [Wen, Dan; Xia, Tianqin] North Sichuan Med Coll, Affiliated Hosp, Pharm Dept, Nucl Med Dept, Nanchong, Peoples R China.
   [Xu, Zhengmin] Key Lab Tradit Chinese Med Prevent & Treatment Ske, Nanchong, Peoples R China.
C3 North Sichuan Medical University; North Sichuan Medical University
RP Xu, ZM; Zhou, CY (corresponding author), North Sichuan Med Coll, Inst Mat Med, 234 Fujiang Rd, Nanchong 637000, Sichuan, Peoples R China.
EM xuzhengmin@nsmc.edu.cn; zhouchunyang@nsmc.edu.cn
RI ; /AAO-7524-2020
OI qing, liao/0009-0005-8567-1982; 
FU Project for First-Class Pharmaceutical Sciences of North Sichuan Medical
   College [CBY21-YLXK03]; Affiliated Hospital of North Sichuan Medical
   College Science and Technology Development Plan [2020ZD002, 2020ZD004];
   Scientific Research Project of North Sichuan Medical College
   [CBY21-ZD04, CBY21-QA31]; National College Student Innovation and
   Entrepreneurship Training Program Project [202210634031]
FX This work was supported by funds from the Project for First-Class
   Pharmaceutical Sciences of North Sichuan Medical College (CBY21-YLXK03),
   Affiliated Hospital of North Sichuan Medical College Science and
   Technology Development Plan (2020ZD002, 2020ZD004), Scientific Research
   Project of North Sichuan Medical College (CBY21-ZD04, CBY21-QA31), and
   National College Student Innovation and Entrepreneurship Training
   Program Project (202210634031).
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NR 35
TC 0
Z9 0
U1 3
U2 7
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2689-5293
EI 2689-5307
J9 ALL LIFE
JI All Life
PD DEC 31
PY 2025
VL 18
IS 1
AR 2515449
DI 10.1080/26895293.2025.2515449
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 3NK2X
UT WOS:001504492500001
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Klancnik, A
   Kuncic, A
   Mozina, SS
   Bucar, F
AF Klancnik, Anja
   Kuncic, Ajda
   Mozina, Sonja Smole
   Bucar, Franz
TI The antibacterial potential and effects of Rhodiola sp. on gut
   microbiota
SO PHYTOCHEMISTRY REVIEWS
LA English
DT Review
DE Rhodiola sp.; Phytochemicals; Antimicrobial activity; Antimicrobial
   resistance; Gut microbiota; Herbal medicine
ID ROSEA L.; EPIGALLOCATECHIN GALLATE; CHEMICAL-COMPOSITION; ANTIOXIDANT
   ACTIVITY; BIOFILM FORMATION; ESSENTIAL OILS; SALIDROSIDE; CAMPYLOBACTER;
   MICE; INFLAMMATION
AB The challenge of antimicrobial resistance requires new solutions, and Rhodiola sp. is a promising candidate due to its rich medicinal history. This review focuses on Rhodiola sp., especially R. rosea, highlighting its phytochemical constituents, such as salidroside, rosavins, and other phenolics, and their antimicrobial potential. We investigate the efficacy of Rhodiola sp. against various pathogenic bacteria, suggesting their value in combating antimicrobial resistance. Additionally, Rhodiola compounds are being investigated both as direct antimicrobials and as resistance modifiers that increase the efficacy of antibiotics. Rhodiola extracts and salidroside modulate gut microbiota, thereby affecting health and physiological and metabolic disorders. This illustrates the comprehensive therapeutic potential of Rhodiola sp. We emphasize the importance of understanding the complex interactions between Rhodiola phytochemicals, their antimicrobial effects, and their effects on gut microbiota as well as the need for in-depth research. Further studies will be crucial for the development of holistic treatment approaches. Finally, Rhodiola sp. is highlighted as an important natural resource in the fight against microbial pathogens and antibiotic resistance. Research on Rhodiola sp. should continue to further unravel pharmacological and health-promoting potential and thus address an important public health challenge.
C1 [Klancnik, Anja; Mozina, Sonja Smole] Univ Ljubljana, Biotech Fac, Dept Food Sci & Technol, Jamnikarjeva 101, Ljubljana 1000, Slovenia.
   [Kuncic, Ajda] Univ Ljubljana, Inst Biochem & Mol Genet, Fac Med, Med Ctr Mol Biol, Vrazov Trg 2, Ljubljana 1000, Slovenia.
   [Bucar, Franz] Graz Univ, Inst Pharmaceut Sci, Dept Pharmacognosy, Beethovenstr 8, A-8010 Graz, Austria.
C3 University of Ljubljana; University of Ljubljana; University of Graz
RP Bucar, F (corresponding author), Graz Univ, Inst Pharmaceut Sci, Dept Pharmacognosy, Beethovenstr 8, A-8010 Graz, Austria.
EM franz.bucar@uni-graz.at
RI Klančnik, Anja/I-4571-2012
OI Bucar, Franz/0000-0002-7417-616X
FU Slovenian Agency for Research and Innovation; University of Graz; 
   [P4-0116];  [J4-4548];  [J4-3088];  [J2-50064]
FX We thank dr. Eva Lasic for reviewing a draft of this manuscript. The
   authors would like to thank the Slovenian Agency for Research and
   Innovation for funding research projects no. P4-0116, J4-4548, J4-3088
   and J2-50064. The authors acknowledge the financial support by the
   University of Graz.
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NR 109
TC 2
Z9 3
U1 2
U2 25
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1568-7767
EI 1572-980X
J9 PHYTOCHEM REV
JI Phytochem. Rev.
PD JUN
PY 2025
VL 24
IS 3
BP 2309
EP 2328
DI 10.1007/s11101-024-09965-5
EA APR 2024
PG 20
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA 3YR8Z
UT WOS:001208963800001
OA hybrid
DA 2026-05-27
ER

PT J
AU Feng, TH
   Shi, J
   Zhao, JH
   Zhao, Q
   Wang, T
   Wan, S
   Fan, C
   Wang, SJ
   Lai, CY
   Yao, YT
AF Feng, Tianhang
   Shi, Jing
   Zhao, Jinghua
   Zhao, Qin
   Wang, Tao
   Wan, Sha
   Fan, Chen
   Wang, Sijia
   Lai, Chunyou
   Yao, Yutong
TI Salidroside can protect against ferroptosis in cardiomyocytes and may be
   related to the regulation of GGT1
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; ferroptosis; myocardial injury; Ggt1; cell death
ID GAMMA-GLUTAMYL-TRANSFERASE; METABOLISM; FAILURE; DAMAGE
AB Indroduction Ferroptosis, an iron-dependent cell death mechanism driven by lipid peroxidation, represents a novel therapeutic target for myocardial injury. Salidroside (SAL), a natural bioactive compound derived from Rhodiola rosea, exhibits cardioprotective effects through multi-target mechanisms with minimal adverse effects, yet its precise role in ferroptosis regulation remains unclear.Methods This study systematically investigated SAL's anti-ferroptotic effects using in vitro (RSL3-induced H9C2 cardiomyocytes) and in vivo (DOX-induced myocardial injury mouse model) approaches.Results SAL treatment significantly enhanced cardiomyocyte viability by attenuating ferroptotic hallmarks, including lipid ROS accumulation, iron overload, lipid peroxidation, and mitochondrial dysfunction. Transcriptomic analysis revealed SAL-mediated modulation of DNA replication/repair, cell cycle regulation, protein autophosphorylation, drug ADME processes, and glutathione metabolism-a critical pathway in ferroptosis. Molecular docking identified gamma-glutamyltransferase 1 (GGT1) as a high-affinity SAL target, linking drug metabolism and glutathione homeostasis. In MI mice, SAL downregulated GGT1 expression while restoring ferroptosis-related biomarkers: upregulating GPX4 and reducing SLC7A11/LC3II levels. Mechanistically, SAL suppresses ferroptosis through dual regulation of GGT1: (1) enhancing glutathione synthesis via GGT1 inhibition and (2) potentiating GPX4-mediated antioxidant defense.Discussion These findings establish GGT1 as a pivotal therapeutic target for SAL's cardioprotection, providing a mechanistic basis for its clinical application in ferroptosis-associated cardiovascular diseases.
C1 [Feng, Tianhang; Wang, Sijia; Lai, Chunyou; Yao, Yutong] Univ Elect Sci & Technol China, Sichuan Prov Hosp, Dept Int Med, Chengdu, Peoples R China.
   [Shi, Jing; Wan, Sha; Fan, Chen] Hosp Chengdu Off Peoples Govt Xizang Autonomous R, Hosp CX, Sci & Educ Sect, Chengdu, Peoples R China.
   [Zhao, Jinghua] Hosp Chengdu Off Peoples Govt Xizang Autonomous R, Hosp CX, Dept Biol Sample Bank, Chengdu, Peoples R China.
   [Zhao, Qin] Hosp Chengdu Off Peoples Govt Xizang Autonomous R, Hosp CX, Dept Cardiol, Chengdu, Peoples R China.
   [Wang, Tao] Univ Elect Sci & Technol China, Med Coll, Chengdu, Sichuan, Peoples R China.
C3 University of Electronic Science & Technology of China; University of
   Electronic Science & Technology of China
RP Wang, SJ; Lai, CY; Yao, YT (corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Hosp, Dept Int Med, Chengdu, Peoples R China.
EM 17760531859@126.com; laichunyou2025@126.comor;
   yaoyutong@med.uestc.edu.cn
FU Science and Technology Project of Tibet Autonomous Region, China
   [XZ202301YD0027C, XZ202501ZR0134]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was financially
   supported by the Science and Technology Project of Tibet Autonomous
   Region, China (JS, Grant No. XZ202301YD0027C) and (JS, Grant No.
   XZ202501ZR0134).
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U2 9
PU FRONTIERS MEDIA SA
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PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
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PD MAY 14
PY 2025
VL 16
AR 1580506
DI 10.3389/fphar.2025.1580506
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 3CP6K
UT WOS:001497138200001
PM 40438595
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Tang, Z
   Wang, Y
   Liu, Y
   Li, CL
AF Tang, Zhe
   Wang, Yong
   Liu, Yan
   Li, Chenglong
TI Salidroside inhibits renal ischemia/reperfusion injury-induced
   ferroptosis by the PI3K/AKT signaling pathway
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE Salidroside; renal ischemia/reperfusion injury; oxidative stress;
   ferroptosis; PI3K/AKT
ID ISCHEMIA-REPERFUSION INJURY
AB Renal ischemia/reperfusion injury (RIRI) represents the principal factor underlying acute kidney injury (AKI), which primarily stems from cellular injuries and ferroptosis caused by reactive oxygen species (ROS). Salidroside (SA), an antioxidant natural ester, has been attributed with the potential to protect against RIRI. In the present study, rats received daily SA doses (1, 10, or 100 mg/kg) by gavage for 7 consecutive days before surgery. The results revealed aggravated renal injury in the RIRI group, which was effectively prevented by SA pretreatment (10 and 100 mg/kg), with the 1 mg/kg dosage demonstrating lesser efficacy. Additionally, the results indicated that SA pretreatment mitigated the RIRI-related upregulation of antioxidative superoxide dismutase. In vitro studies corroborated SA's ability to maintain hypoxia/reoxygenation-treated NRK cell viability, with the protective effect being observed at SA concentrations >= 1 mu M and peaking at 100 mu M. Furthermore, the results showed that SA safeguarded renal tubular epithelial cells from oxidative damage, reduced ROS accumulation, and inhibited ferroptosis via activation of the PI3K/AKT signaling pathway. Therefore, the results of the present study highlight the promising therapeutic potential of SA as an effective intervention for RIRI via targeting of PI3K/AKT signaling pathway-mediated anti-oxidative and anti-ferroptotic mechanisms.
C1 [Tang, Zhe] Yangtze Univ, Peoples Hosp Jing Zhou 1, Affiliated Hosp 1, Dept Urol, Jingzhou 434000, Hubei, Peoples R China.
   [Wang, Yong] Ying Shan Hosp Tradit Chinese Med, Dept Urol, Ying Shan 438700, Hubei, Peoples R China.
   [Liu, Yan; Li, Chenglong] Wuhan Univ, Renmin Hosp, Dept Urol, Wuhan 430060, Hubei, Peoples R China.
   [Li, Chenglong] Wuhan Univ, Renmin Hosp, Dept Urol, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China.
C3 Yangtze University; Wuhan University; Wuhan University
RP Li, CL (corresponding author), Wuhan Univ, Renmin Hosp, Dept Urol, 238 Jiefang Rd, Wuhan 430060, Hubei, Peoples R China.
EM 492847537@qq.com
FU Not applicable.
FX Not applicable.
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IS 5
AR 507
DI 10.3892/etm.2023.12206
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA T6EI0
UT WOS:001078895100001
PM 37822587
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Guo, XQ
   Qi, L
   Yang, J
   Wang, Y
   Wang, C
   Li, ZM
   Li, L
   Qu, Y
   Wang, D
   Han, ZM
AF Guo, Xiao Qin
   Qi, Lin
   Yang, Jing
   Wang, Yue
   Wang, Chuan
   Li, Zong Min
   Li, Ling
   Qu, Ye
   Wang, Dan
   Han, Ze Min
TI Salidroside accelerates fracture healing through cell-autonomous and
   non-autonomous effects on osteoblasts
SO CELL AND TISSUE RESEARCH
LA English
DT Article
DE Salidroside; Osteoblast; Hypoxia-inducible factor-1 alpha (HIF-1 alpha);
   Vascular endothelial growth factor (VEGF); Fracture
ID HYPOXIA-INDUCIBLE FACTOR; HIPPEL-LINDAU PROTEIN; BONE-FORMATION;
   FUTURE-DIRECTIONS; NONUNION MODEL; DIFFERENTIATION; ANGIOGENESIS;
   EXPRESSION; OSTERIX; FACTOR-1-ALPHA
AB Salidroside (SAL), a major active component of Rhodiola rosea L., exhibits diverse pharmacological effects. However, the direct roles of SAL in fracture healing remain largely unknown. Here, we demonstrate that SAL significantly promotes proliferation by altering the cell-cycle distribution of osteoblastic cells. SAL also greatly stimulates osteoblast differentiation and mineralization by inducing the expression of Runx2 and Osterix. In addition to its osteoblast-autonomous effects, SAL can activate the HIF-1 alpha pathway coupling of angiogenesis and osteogenesis through cell-non-autonomous effects. Our in vitro results suggest that SAL significantly up-regulates HIF-1 alpha expression at the mRNA and protein levels. Furthermore, the nuclear translocation and transcriptional activity of HIF-1 alpha and the HIF-responsive gene VEGF increase following SAL treatment. Our mechanistic study revealed that the regulation of osteoblastic proliferation and HIF-1 alpha expression partly involves MAPK/ERK and PI3K/Akt signaling. Our in vivo analysis also demonstrated that SAL can promote angiogenesis within the callus and accelerate fracture healing. Thus, SAL promotes skeletal regeneration in cell-autonomous and cell-non-autonomous ways and might be a potential therapy for accelerating fracture healing.
C1 [Guo, Xiao Qin; Wang, Yue] Tianjin Key Lab Prevent & Control Occupat & Envir, Tianjin, Peoples R China.
   [Guo, Xiao Qin; Qi, Lin; Yang, Jing; Wang, Yue; Li, Zong Min; Qu, Ye; Wang, Dan] Logist Coll Chinese Peoples Armed Police Forces, Dept Pathogen Biol & Immunol, Huizhi Ring Rd 1, Tianjin 300309, Peoples R China.
   [Wang, Chuan; Han, Ze Min] Logist Coll Chinese Peoples Armed Police Forces, Dept Stomatol, Affiliated Hosp, Tianjin, Peoples R China.
   [Li, Ling] Logist Coll Chinese Peoples Armed Police Forces, Dept Pharmacol, Tianjin, Peoples R China.
RP Wang, Y (corresponding author), Tianjin Key Lab Prevent & Control Occupat & Envir, Tianjin, Peoples R China.; Wang, Y (corresponding author), Logist Coll Chinese Peoples Armed Police Forces, Dept Pathogen Biol & Immunol, Huizhi Ring Rd 1, Tianjin 300309, Peoples R China.; Han, ZM (corresponding author), Logist Coll Chinese Peoples Armed Police Forces, Dept Stomatol, Affiliated Hosp, Tianjin, Peoples R China.
EM wangyue6808@126.com; 6666665901@sina.com
RI Guo, Xiaoqin/OHU-6833-2025
FU National Natural Science Foundation of China [81273520, 81572852,
   81502256]; Great Program of the Science Foundation of Tianjin
   [12JCZDJC26300, 15JCYBJC28900]; Great Program for Science and Technology
   in Logistics College of Chinese People's Armed Police Forces [WHZ201202,
   WHB201404, WHB201405, WHB201406]
FX This work was supported by grants from the National Natural Science
   Foundation of China (nos. 81273520, 81572852, and 81502256), the Great
   Program of the Science Foundation of Tianjin (nos. 12JCZDJC26300 and
   15JCYBJC28900) and the Great Program for Science and Technology in
   Logistics College of Chinese People's Armed Police Forces (nos.
   WHZ201202, WHB201404, WHB201405 and WHB201406).
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NR 42
TC 21
Z9 29
U1 1
U2 27
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0302-766X
EI 1432-0878
J9 CELL TISSUE RES
JI Cell Tissue Res.
PD FEB
PY 2017
VL 367
IS 2
BP 197
EP 211
DI 10.1007/s00441-016-2535-2
PG 15
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EK0TZ
UT WOS:000393641300004
PM 27942852
DA 2026-05-27
ER

PT J
AU Ou, CY
   Gao, X
   Wang, JJ
   Chen, XL
   Cao, L
   Wang, ZZ
   Zhang, CF
   Xiao, W
AF Ou, Chun-Yan
   Gao, Xia
   Wang, Jia-Jia
   Chen, Xia-Lin
   Cao, Liang
   Wang, Zhen-Zhong
   Zhang, Chen-Feng
   Xiao, Wei
TI Characterization of metabolic profile of Dazhu Hongjingtian and
   evaluation of its anti-hypoxic constituents
SO JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
LA English
DT Article
DE Dazhu Hongjingtian extract; metabolic profile; anti-hypoxic
   constituents; UPLC/Q-TOF-MS/MS; RSC96 cells
ID FLIGHT MASS-SPECTROMETRY; RAT PLASMA; SALIDROSIDE; CAPSULE; ROOT
AB Dazhu Hongjingtian (DZ) is renowned for its diverse pharmacological activities, yet its metabolic pathways remain to be fully elucidated. In this study, the metabolic profile after oral administration of DZ extract (DZE) in rats was systematically identified by the UPLC/Q-TOF-MS/MS method for the first time. A total of 94 components, including 32 prototypes and 62 metabolites, were tentatively characterized in rat plasma and various tissues samples. Furthermore, 6 constituents (salidroside, quercetin, 4-hydroxycinnamic acid, 5-hydroxymethylfurfural, p-tyrosol, and gallic acid) derived from plasma prototypes were identified as bioactive by assessing cell viabilities of OGD-injured RSC96 cells.
C1 [Ou, Chun-Yan] Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Peoples R China.
   [Ou, Chun-Yan; Gao, Xia; Wang, Jia-Jia; Chen, Xia-Lin; Cao, Liang; Wang, Zhen-Zhong; Zhang, Chen-Feng; Xiao, Wei] Jiangsu Kanion Pharmaceut Co Ltd, Lianyungang 222001, Peoples R China.
C3 Nanjing University of Chinese Medicine
RP Xiao, W (corresponding author), Jiangsu Kanion Pharmaceut Co Ltd, Lianyungang 222001, Peoples R China.
EM xw_kanion@163.com
RI xiao, wei/KCK-6954-2024
FU Jiangsu Kanion Pharmaceutical Co., Ltd.
FX The authors are grateful to Jiangsu Kanion Pharmaceutical Co., Ltd. for
   the grant.
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NR 42
TC 0
Z9 0
U1 3
U2 11
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1028-6020
EI 1477-2213
J9 J ASIAN NAT PROD RES
JI J. Asian Nat. Prod. Res.
PD MAY 4
PY 2025
VL 27
IS 5
BP 690
EP 708
DI 10.1080/10286020.2024.2434550
EA DEC 2024
PG 19
WC Plant Sciences; Chemistry, Applied; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Pharmacology & Pharmacy
GA 2DZ5I
UT WOS:001375884000001
PM 39665404
DA 2026-05-27
ER

PT J
AU Wang, MJ
   Tu, T
   Wang, YXY
   Tian, LM
   Yang, YN
AF Wang, Mengjie
   Tu, Tuyagaer
   Wang, Yangxingyun
   Tian, Limin
   Yang, Yuenan
TI Salidroside alleviates imiquimod-induced psoriasis by inhibiting
   GSDMD-driven keratinocyte pyroptosis
SO BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
LA English
DT Article
DE GSDMD; macrophage; psoriasis; pyroptosis; salidroside
ID SKIN INFLAMMATION; MACROPHAGES
AB Psoriasis is a common immune-related polygenic inflammatory skin disease. Salidroside (SAL) exerts anti-inflammatory and antioxidant effects and is used to treat skin diseases. However, the specific effects of SAL on psoriasis remain unclear. In this study, we aimed to investigate the efficacy of SAL for psoriasis treatment. Mice were treated with imiquimod (IMQ) to establish an in vivo psoriasis model. Histological analysis was conducted via hematoxylin and eosin staining. Cytokine release was determined via enzyme-linked immunosorbent assay. Additionally, mRNA levels were determined via reverse transcription-quantitative polymerase chain reaction. Protein expression was assessed via Western blotting. Gasdermin D (GSDMD) and Ki-67 expression levels were determined via immunohistochemistry. Caspase 1 and GSDMD expression levels were determined via immunofluorescence assay. Furthermore, macrophage function and keratinocyte pyroptosis were also analyzed via flow cytometry. Cell proliferation was determined using 5-ethynyl-2 ' deoxyuridine assay. SAL alleviated IMQ-induced psoriasis. IMQ-mediated GSDMD-driven pyroptosis and keratinocyte hyperproliferation promoted M1 macrophage polarization. However, SAL treatment suppressed GSDMD expression, thereby inhibiting keratinocyte proliferation and pyroptosis and promoting M2 macrophage polarization. GSDMD deficiency further promoted the effects of SAL and suppressed psoriasis progression. Overall, our findings suggest that SAL exerts protective effects against psoriasis. Specifically, it exerts anti-inflammatory effects by regulating M2 macrophage polarization and inhibiting keratinocyte pyroptosis-driven proliferation induced by the immune microenvironment in psoriasis.
C1 [Wang, Mengjie; Tu, Tuyagaer; Wang, Yangxingyun] Inner Mongolia Univ Sci & Technol, Baotou Med Coll, Dept Dermatol & Surg, Baotou, Peoples R China.
   [Tian, Limin; Yang, Yuenan] Inner Mongolia Univ Sci & Technol, Affiliated Hosp 1, Baotou Med Coll, Dept Dermatol, 41 Linyin Rd, Baotou 014010, Inner Mongolia, Peoples R China.
C3 Inner Mongolia University of Science & Technology; Baotou Medical
   College; Baotou Medical College; Inner Mongolia University of Science &
   Technology
RP Yang, YN (corresponding author), Inner Mongolia Univ Sci & Technol, Affiliated Hosp 1, Baotou Med Coll, Dept Dermatol, 41 Linyin Rd, Baotou 014010, Inner Mongolia, Peoples R China.
EM yangyuenandr@yeah.net
RI Wang, xiaoxiao/GQQ-2846-2022
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NR 48
TC 3
Z9 3
U1 2
U2 9
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-4513
EI 1470-8744
J9 BIOTECHNOL APPL BIOC
JI Biotechnol. Appl. Biochem.
PD APR
PY 2025
VL 72
IS 2
BP 355
EP 368
DI 10.1002/bab.2668
EA SEP 2024
PG 14
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA EM9JR
UT WOS:001312608900001
PM 39279255
DA 2026-05-27
ER

PT J
AU Hu, GS
   Jia, JM
   Doh Hoon, K
AF Hu Gao-Sheng
   Jia Jing-Ming
   Doh Hoon Kim
TI Effects of feeding tyrosine and phenylalanine on the accumulation of
   phenylethanoid glycosides to Cistanche deserticola cell
   suspension culture
SO CHINESE JOURNAL OF NATURAL MEDICINES
LA English
DT Article
DE Cistanche deserticola; Cell suspension culture; Phenylalanine; Tyrosine;
   Precursor feeding; RP-HPLC; Salidroside; Biosynthesis; Phenylethanoid
   glycosides
ID 1-METHYL-4-PHENYLPYRIDINIUM ION; SALIDROSIDE PRODUCTION; SALSA;
   IMPROVEMENT; APOPTOSIS; BIOSYNTHESIS
AB AIM: To investigate the effects of feeding phenylalanine (Phe) and tyrosine (Tyr) on the accumulation of total phenolic compounds and four phenylethanoid glycosides (PeGs) to a cell suspension culture of the parasitic plant Cistanche deserticola.
   METHOD: A cell suspension culture of C. deserticola was established and precursors of different concentrations were fed. In each group, the cell was sampled at the 24th day after inoculation. The content of total phenolic compounds and four PeGs compounds were determined using the Folin-Ciocalteu method and an HPLC method, respectively.
   RESULTS: In the Phe fed cells, the maximum PeGs yield was achieved when Phe was fed at 1.5 mmol.L-1 and the yield reached 1.13 times the control cell concentration. hi the Tyr fed cells, the maximum yield of PeGs was 1.60 times of control when 0.75 mmol.L-1:1 Tyr was fed to the cells. Furthermore, it was found that the salidroside yield was 4.01 times of control group when 5 mmol.L-1 Tyr was fed.
   CONCLUSION: Tyr is a better precursor for PeGs accumulation compared with Phe, and the rate limiting enzymes might be involved in the Tyr branch.
C1 [Hu Gao-Sheng; Jia Jing-Ming] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang 110016, South Korea.
   [Hu Gao-Sheng; Jia Jing-Ming; Doh Hoon Kim] Shenyang Pharmaceut Univ, Joint Lab, Shenyang 110016, South Korea.
   [Hu Gao-Sheng; Jia Jing-Ming; Doh Hoon Kim] Dong A Univ, Shenyang 110016, South Korea.
   [Doh Hoon Kim] Dong A Univ, Coll Life Sci & Nat Resources, Busan 604714, South Korea.
C3 Dong A University; Dong A University
RP Doh Hoon, K (corresponding author), Shenyang Pharmaceut Univ, Joint Lab, Shenyang 110016, South Korea.
EM dhkim@dau.ac.kr
FU Dong A University
FX This experiment was funded by Dong A University. The authors also would
   like to express appreciation to Dr. Nobuhisa Ezaki at Yomeishu Seizo
   Company for providing the standard compounds echinacoside, acteoside,
   and cistanoside A.
CR Cheng XY, 2006, J BIOTECHNOL, V121, P253, DOI 10.1016/j.jbiotec.2005.07.012
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NR 18
TC 19
Z9 21
U1 0
U2 26
PU CHINESE JOURNAL NATURAL MEDICINES
PI NANJING
PA 24, TONGJIA XIANG, NANJING, 210009, PEOPLES R CHINA
SN 2095-6975
EI 1875-5364
J9 CHIN J NAT MEDICINES
JI Chin. J. Nat. Med.
PD MAY
PY 2014
VL 12
IS 5
BP 367
EP 372
DI 10.1016/S1875-5364(14)60045-5
PG 6
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA AJ3FQ
UT WOS:000337552300006
PM 24856760
DA 2026-05-27
ER

PT J
AU Li, FY
   Mao, QQ
   Wang, JY
   Zhang, XY
   Lv, XY
   Wu, B
   Yan, TX
   Jia, Y
AF Li, Fuyuan
   Mao, Qianqian
   Wang, Jinyu
   Zhang, Xiaoying
   Lv, Xinyan
   Wu, Bo
   Yan, Tingxu
   Jia, Ying
TI Salidroside inhibited cerebral ischemia/reperfusion-induced oxidative
   stress and apoptosis via Nrf2/Trx1 signaling pathway
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Cerebral ischemia; reperfusion; Salidroside; Nrf2; Trx1; Oxidative
   stress; Apoptosis
ID THIOREDOXIN-1; INJURY; BRAIN
AB Cerebral ischemia reperfusion injury (CIRI) is still a serious problem threatening human health. Salidroside (SAL) is a natural phenylpropanoid glycoside compound with antioxidant, anti-inflammatory, and anti-ischemic properties. This study investigated the protective mechanism of SAL on middle cerebral artery occlusion (MCAO)- and oxygen-glucose deprivation/reoxygenation (OGD/R) model-induced CIRI via regulating the nuclear factor erythroid 2-related factor 2 (Nrf2)/thioredoxin 1 (Trx1) axis. The results indicated that SAL (50 mg/kg or 100 mg/kg, intraperitoneal injection) not only effectively alleviated infarction rate, improved histopathological changes, relieved apoptosis by strengthening the suppression of cleaved caspase-3 and Bax/Bcl-2 proteins and decreased malondialdehyde (MDA) formation, but also increased superoxide dismutase (SOD) and catalase (CAT) activities and upregulated the expressions of Nrf2 and Trx1 on MCAO-induced CIRI rats. SAL also efficiently inhibited apoptosis and decreased oxidative stress in OGD/R-stimulated PC12 cells. Furthermore, blocking the Nrf2/Trx1 pathway using tretinoin, an Nrf2 inhibitor, significantly reversed the protective effect of SAL on OGD/R-induced oxidative stress. Moreover, SAL reduced the expression of apoptosis signal-regulating kinase-1 (ASK1) and mitogen-activated protein kinase (MAPK) family proteins. These results demonstrated that SAL inhibited oxidative stress through Nrf2/Trx1 signaling pathway, and subsequently reduced CIRI-induced apoptosis by inhibiting ASK1/MAPK.
C1 [Li, Fuyuan; Mao, Qianqian; Zhang, Xiaoying; Lv, Xinyan] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang, Peoples R China.
   [Wang, Jinyu; Wu, Bo; Yan, Tingxu; Jia, Ying] Shenyang Pharmaceut Univ, Sch Funct Food & Wine, 103 Wenhua Rd, Shenyang, Peoples R China.
C3 Shenyang Pharmaceutical University; Shenyang Pharmaceutical University
RP Yan, TX; Jia, Y (corresponding author), Shenyang Pharmaceut Univ, Sch Funct Food & Wine, 103 Wenhua Rd, Shenyang, Peoples R China.
EM yantingxu@126.com; jiayingsyphu@126.com
OI Zhang, Xiaoying/0000-0001-8057-0764
FU National Natural Science Foundation of China [82173961]; Key Laboratory
   of polysaccharide bioactivity evaluation of TCM of Liaoning Province,
   Liaoning Distinguished Professor Project for Ying Jia; Highlevel
   innovation and entrepreneurship team of Liaoning Province [XLYC2008029];
   Liaoning Provincial Department of Education Fund [LJKZ0911, LJKZ0950]
FX This research was supported by National Natural Science Foundation of
   China (No. 82173961), Key Laboratory of polysaccharide bioactivity
   evaluation of TCM of Liaoning Province, Liaoning Distinguished Professor
   Project for Ying Jia (2017), Highlevel innovation and entrepreneurship
   team of Liaoning Province (XLYC2008029), Liaoning Provincial Department
   of Education Fund (LJKZ0911, LJKZ0950).
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NR 33
TC 36
Z9 42
U1 0
U2 19
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD DEC
PY 2022
VL 37
IS 8
BP 2965
EP 2978
DI 10.1007/s11011-022-01061-x
EA AUG 2022
PG 14
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA 6G5AQ
UT WOS:000843619800001
PM 35976554
DA 2026-05-27
ER

PT J
AU Hao, YJ
   Ye, WQ
   Wang, M
   Liu, LL
   Yu, S
   Piao, XC
   Lian, ML
AF Hao, Yue-Jun
   Ye, Wei-Qi
   Wang, Miao
   Liu, Liang-Liang
   Yu, Shuo
   Piao, Xuan-Chun
   Lian, Mei-Lan
TI Selection of initial culture medium in fed-batch bioreactor culture of
   Rhodiola sachalinensis cells
SO JOURNAL OF BIOTECHNOLOGY
LA English
DT Article
DE Initial medium; Medium volume; Medium strength; Sucrose concentration;
   AHP-TOPSIS
ID SUSPENSION-CULTURES; ADVENTITIOUS ROOT; SALIDROSIDE; TOPSIS; AHP
AB In fed-batch culture, numerous factors, such as initial culture conditions and feeding strategies, affect the culture efficiency. Among the factors, the effect of initial culture medium is rarely investigated. In this work, Rhodiola sachalinensis cells were cultured in the fed-batch bioreactor system and the effects of volume, medium strength, and sucrose concentration of initial culture medium on biomass and accumulation of salidroside, polysaccharides, flavonoids, and phenolics were investigated. The results showed that an initial medium volume of 3 L significantly (p < 0.05) increased biomass and the four bioactive compound contents. The maximum biomass and the highest contents of different bioactive compounds were determined at various MS medium strengths. Therefore, analytic hierarchy process (AHP) - technique for order preference by similarity to ideal solution (TOPSIS) was implemented and half-strength MS medium was selected. Furthermore, the effect of sucrose concentration was examined and 30 g/L sucrose in the initial medium was optimal, at which concentration, 39.45 mg/g DW of salidroside, 531.25 mg/g DW of total polysaccharides, 3.89 mg/g DW of total flavonoids, and 10.84 mg/g DW of total phenolics were produced. The findings of the present study provided a reference for further establishing the fed-batch culture system of R. sachalinensis cells.
C1 [Hao, Yue-Jun; Ye, Wei-Qi; Wang, Miao; Liu, Liang-Liang; Yu, Shuo; Piao, Xuan-Chun; Lian, Mei-Lan] Yanbian Univ, Key Lab Nat Med Changbai Mt, Minist Educ, Pk Rd 977, Yanji 133002, Jilin, Peoples R China.
C3 Yanbian University
RP Piao, XC; Lian, ML (corresponding author), Yanbian Univ, Key Lab Nat Med Changbai Mt, Minist Educ, Pk Rd 977, Yanji 133002, Jilin, Peoples R China.
EM nyypxc@ybu.edu.cn; lianmeilan2001@163.com
FU National Natural Science Foundation of China [81960685, 81160497]
FX This work was supported by National Natural Science Foundation of China
   (81960685 and 81160497).
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NR 33
TC 10
Z9 10
U1 1
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0168-1656
EI 1873-4863
J9 J BIOTECHNOL
JI J. Biotechnol.
PD FEB 20
PY 2022
VL 346
BP 15
EP 22
DI 10.1016/j.jbiotec.2022.01.005
EA FEB 2022
PG 8
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA ZO8JP
UT WOS:000765973500003
PM 35093491
DA 2026-05-27
ER

PT J
AU Ju, HY
   Chen, SC
   Wu, KJ
   Kuo, HC
   Hseu, YC
   Ching, H
   Wu, CR
AF Ju, Heng-Yin
   Chen, Shiu Ching
   Wu, Kuo-Jen
   Kuo, Hui-Chun
   Hseu, You-Cheng
   Ching, Hui
   Wu, Chi-Rei
TI Antioxidant phenolic profile from ethyl acetate fraction of Fructus
   Ligustri Lucidi with protection against hydrogen peroxide-induced
   oxidative damage in SH-SY5Y cells
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Fructus Ligustri Lucidi; Hydroxytyrosol; Salidroside; Antioxidant
   activity; Oxidative stress; Antioxidant enzymes
ID VASCULAR ENDOTHELIAL-CELLS; NEURODEGENERATIVE DISEASES; OLEANOLIC ACID;
   OLIVE OIL; STRESS; HYDROXYTYROSOL; SALIDROSIDE; SUPEROXIDE; ACTIVATION;
   APOPTOSIS
AB In this study, we demonstrated the antioxidant and protective properties of crude extract and fractions from Fructus Ligustri Lucidi (FLL) against hydrogen peroxide (H2O2)-induced oxidative damage in SH-SY5Y cells. The contents of their phytochemical profiles were determined by spectrophotometric methods and high performance liquid chromatography using a photodiode array detector. FLL crude extract possessed appreciable scavenging capacity against 1,1-diphenyl-2-picrylhydrazyl and H2O2. The ethyl acetate (EtOAc) fraction was the most active fraction in scavenging free radicals and H2O2. Following exposure of cells to H2O2, there was a marked decrease in cell survival and intracellular antioxidant enzymes, and then intracellular oxidative stress, the level of lipid peroxidation, and caspase-3 activity were increased. Simultaneous treatment with the EtOAc fraction blocked these H2O2-induced cellular events. Hydroxytyrosol and salidroside are major components of the EtOAc fraction. These results show that the phenolic-enriched EtOAc fraction of FLL contains tyrosol-related derivatives and exerts the protective effects against H2O2 toxicity via its free radical scavenging activity and ability to elevate the levels of antioxidant enzymes. (C) 2011 Elsevier Ltd. All rights reserved.
C1 [Ju, Heng-Yin; Wu, Kuo-Jen; Kuo, Hui-Chun; Wu, Chi-Rei] China Med Univ, Coll Pharm, Sch Chinese Pharmaceut Sci & Chinese Med Resource, Taichung 40402, Taiwan.
   [Chen, Shiu Ching; Ching, Hui] Taichung Hosp, Execut Yuan, Dept Hlth, Taichung 40403, Taiwan.
   [Hseu, You-Cheng] China Med Univ, Coll Pharm, Dept Cosmeceut, Taichung 40402, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan
RP Wu, CR (corresponding author), China Med Univ, Coll Pharm, Sch Chinese Pharmaceut Sci & Chinese Med Resource, 91 Hsueh Shih Rd, Taichung 40402, Taiwan.
EM crw@mail.cmu.edu.tw
RI Wu, Chi-Rei/X-9546-2019
OI Wu, Chi-Rei/0000-0002-7036-5035
FU China Medical University [CMU94-019, CMU95-PH-02]; Chinese Medicine
   Committee [CCMP94-RD-013]; National Sciences Council
   [NSC97-2320-B-039-041, NSC98-2320-B-039-041 MY3]
FX We thank the financial support of the China Medical University CMU94-019
   and CMU95-PH-02, Chinese Medicine Committee CCMP94-RD-013, and National
   Sciences Council NSC97-2320-B-039-041 and NSC98-2320-B-039-041 MY3.
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NR 32
TC 67
Z9 81
U1 1
U2 26
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD MAR-APR
PY 2012
VL 50
IS 3-4
BP 492
EP 502
DI 10.1016/j.fct.2011.11.036
PG 11
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA 932IR
UT WOS:000303284600008
PM 22142696
DA 2026-05-27
ER

PT J
AU Wang, X
   Cao, SX
   Huang, Y
   Li, LC
   Xu, DY
   Liu, L
AF Wang, Xin
   Cao, Shuxia
   Huang, Yuan
   Li, Liangchang
   Xu, Dongyuan
   Liu, Lan
TI Salidroside alleviates cholestasis-induced liver fibrosis by inhibiting
   hepatic stellate cells via activation of the PI3K/AKT/GSK-3β signaling
   pathway and regulating intestinal flora distribution
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; cholestatic liver fibrosis; hepatic stellate cells;
   intestinal flora; PI3K/Akt/GSK-3 beta pathway
ID OXIDATIVE STRESS; INJURY; INFLAMMATION; RATS
AB Salidroside (SAL), a phenylpropanoid bioactive compound, has various pharmacological properties, including antioxidant, anti-inflammatory, and hepatoprotective effects. However, the pharmacological effects and mechanisms of action of SAL on cholestatic liver injury are unclear. This study investigated the mechanism and effects of salidroside (SAL) on intestinal flora distribution and hepatic stellate cell (HSC) activation in cholestatic hepatic fibrosis. Bile duct ligation was used to cause cholestasis BALB/c mice. The therapeutic efficacy of SAL in liver fibrosis was assessed via serum/tissue biochemical analyses and liver tissue hematoxylin and eosin and Masson staining. Inflammation and oxidative stress were analyzed using enzyme-linked immunosorbent assay and western blotting. HSC were activated in vitro using lipopolysaccharide, and the effects of SAL on HSC migration and inflammatory factor expression were detected via scratch, transwell, and western blotting assays. The effects of SAL on the PI3K/AKT/GSK-3 beta pathway in vivo and in vitro were detected using western blotting. 16sRNA sequencing was used to detect the effect of SAL on the diversity of the intestinal flora. Ileal histopathology and western blotting were used to detect the protective effect of SAL on the intestinal mucosal barrier. SAL reduces liver inflammation and oxidative stress and protects against liver fibrosis with cholestasis. It inhibits HSC activation and activates the PI3K/AKT/GSK-3 beta pathway in vitro and in vivo. Additionally, SAL restores the abundance of intestinal flora, which contributes to the repair of the intestinal mucosal barrier, inhibits endotoxin translocation, and indirectly inhibits HSC activation, reversing the course of cholestatic liver fibrosis. SAL inhibits HSC activation through the PI3K/AKT/GSK-3 beta pathway and improves intestinal flora distribution, thereby protecting and reversing the progression of hepatic fibrosis.
C1 [Wang, Xin; Cao, Shuxia; Huang, Yuan; Li, Liangchang; Xu, Dongyuan; Liu, Lan] Yanbian Univ, Key Lab Cellular Funct & Pharmacol Jilin Prov, Yanji, Peoples R China.
   [Liu, Lan] Yanbian Univ Hosp, Dept Pathol, Yanji, Peoples R China.
C3 Yanbian University; Yanbian University
RP Xu, DY; Liu, L (corresponding author), Yanbian Univ, Key Lab Cellular Funct & Pharmacol Jilin Prov, Yanji, Peoples R China.; Liu, L (corresponding author), Yanbian Univ Hosp, Dept Pathol, Yanji, Peoples R China.
EM dyxu@ybu.edu.cn; lliu@ybu.edu.cn
OI Li, Liangchang/0000-0003-1931-6673
FU National Natural Science Foundation of China [31860321]; Natural Science
   Research Foundation of Jilin Province for Sciences and Technology
   [YDZJ202301ZYTS173]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This study was
   supported by the National Natural Science Foundation of China (31860321,
   LaL) and The Natural Science Research Foundation of Jilin Province for
   Sciences and Technology (YDZJ202301ZYTS173, LaL; 20220101355JC DX).
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NR 35
TC 10
Z9 12
U1 1
U2 22
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAY 14
PY 2024
VL 15
AR 1396023
DI 10.3389/fphar.2024.1396023
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SB1Z6
UT WOS:001231921800001
PM 38808258
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Fan, Y
   Bi, YJ
   Chen, HX
AF Fan, Yang
   Bi, Yajuan
   Chen, Haixia
TI Salidroside Improves Chronic Stress Induced Depressive Symptoms Through
   Microglial Activation Suppression
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; neuroinflammation; microglia; depressive behavior; LPS
ID CLINICAL-PRACTICE GUIDELINES; COGNITIVE IMPAIRMENT; ALZHEIMERS-DISEASE;
   MODEL; MICE; HIPPOCAMPUS; EXPRESSION; CELLS; BRAIN; INFLAMMATION
AB Depression is a severe neurological disorder highly associated with chronic mental stress stimulation, which involves chronic inflammation and microglial activation in the central nervous system (CNS). Salidroside (SLDS) has been reported to exhibit anti-neuroinflammatory and protective properties on neurological diseases. However, the mechanism underlying the effect of SLDS on depressive symptoms has not been well elaborated. In the present study, the effects of SLDS on depressive behaviors and microglia activation in mice CNS were investigated. Behavioral tests, including Forced swimming test (FST), Open field test (OFT) and Morris water maze (MWM) revealed that SLDS treatment attenuated the depressive behaviors in stress mice. SLDS treatment significantly reduced the microglial immunoreactivity for both Iba-1 and CD68, characteristic of deleterious M1 phenotype in hippocampus of stress mice. Additionally, SLDS inhibited microglial activation involving the suppression of ERK1/2, P38 MAPK and p65 NF-kappa B activation and thus reduced the expression and release of neuroinflammatory cytokines in stress mice as well as in lipopolysaccharide (LPS)-induced primary microglia. Also, SLDS changed microglial morphology, attachment and reduced the phagocytic ability in LPS-induced primary microglia. The results demonstrated that SLDS treatment could improve the depressive symptoms caused by unpredictable chronic stress, indicating a potential therapeutic application of SLDS in depression treatment by interfering microglia-mediated neuroinflammation.
C1 [Fan, Yang; Bi, Yajuan; Chen, Haixia] Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin, Peoples R China.
C3 Tianjin University
RP Chen, HX (corresponding author), Tianjin Univ, Sch Pharmaceut Sci & Technol, Tianjin, Peoples R China.
EM chenhx@tju.edu.cn
RI Chen, Haixia/K-1661-2015
OI Chen, Haixia/0000-0002-2596-9622
FU Double First Plan of Tianjin University [2900903075103]
FX This work was supported by a grant from Double First Plan of Tianjin
   University (No. 2900903075103)
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NR 76
TC 24
Z9 26
U1 1
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUN 8
PY 2021
VL 12
AR 635762
DI 10.3389/fphar.2021.635762
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Social Science Citation Index (SSCI)
SC Pharmacology & Pharmacy
GA SW5TE
UT WOS:000664576800001
PM 34168556
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Ding, XR
   Wang, WL
   Chen, JW
   Zhao, QQ
   Lu, PH
   Lu, LJ
AF Ding, Xuerui
   Wang, Weilong
   Chen, Jiawei
   Zhao, Qianqian
   Lu, Peiheng
   Lu, Lianjun
TI Salidroside protects inner ear hair cells and spiral ganglion neurons
   from manganese exposure by regulating ROS levels and inhibiting
   apoptosis
SO TOXICOLOGY LETTERS
LA English
DT Article
DE Manganese; Hair cells; Spiral ganglion neurons; Salidroside; Apoptosis
ID OXIDATIVE STRESS; RHODIOLA-ROSEA; INDUCED OTOTOXICITY; LIFE-SPAN;
   IN-VITRO; COCHLEAR; DEATH; NEUROTOXICITY; RESISTANCE
AB Manganese (Mn) is an essential cofactor for many enzymes and thus plays an important role in normal growth and development. However, persistent exposure to high Mn concentrations can result in deleterious effects on not only the central nervous system but also peripheral nerves, including nerves associated with the auditory system. Our initial research on cochlear organotypic cultures in vitro showed that N-acetylcysteine (NAC) clearly decreases Mn-induced losses in hair cells (HCs), auditory nerve fibers (ANFs) and spiral ganglion neurons (SGNs) in a concentration-dependent manner. Salidroside (SAL) (p-hydroxyphenethyl-b-D-glucoside; C14H20O7), which is extracted from Rhodiola rosea L, has many pharmacological actions and antioxidative, antiaging, neuroprotective and anticancer effects. We hypothesized that SAL could also protect HCs, ANFs and SGNs from Mn injury. Cochlear organotypic cultures were treated with 1mM Mn alone or combined with SAL (1-1000 mu M). The neurofilament staining results showed that HCs, ANFs and SGNs were seriously damaged at high concentrations (100-1000 mu M) but less damaged at low concentrations (1-10 mu M). SAL may protect against 1mM Mn-induced HC loss and axonal degeneration, suggesting that SAL could be a promising drug for clinical applications.
C1 [Ding, Xuerui; Wang, Weilong; Chen, Jiawei; Zhao, Qianqian; Lu, Peiheng; Lu, Lianjun] Air Force Med Univ, Tangdu Hosp, Dept Otolaryngol Head & Neck Surg, Xian 710038, Shaanxi, Peoples R China.
C3 Air Force Medical University
RP Lu, LJ (corresponding author), Air Force Med Univ, Tangdu Hosp, Dept Otolaryngol Head & Neck Surg, Xian 710038, Shaanxi, Peoples R China.
EM lianj@fmmu.edu.cn
RI ; zhao, qianqian/AEF-4159-2022
OI Lu, Lianjun/0000-0002-1460-1961; 
FU Shanxi Province Science and Technology Research and Development Program
   Project [S2016YFSF0547]
FX This work was supported by grants from the Shanxi Province Science and
   Technology Research and Development Program Project (No. S2016YFSF0547)
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Z9 19
U1 0
U2 30
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-4274
EI 1879-3169
J9 TOXICOL LETT
JI Toxicol. Lett.
PD AUG
PY 2019
VL 310
BP 51
EP 60
DI 10.1016/j.toxlet.2019.04.016
PG 10
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA HW7CN
UT WOS:000466847600007
PM 30991096
DA 2026-05-27
ER

PT J
AU He, K
   Cheng, LS
   Yang, HY
   Zhang, CX
   Shen, LF
   Liu, Q
   Yan, HX
   Zhao, LL
   Yang, S
AF He, Kuo
   Cheng, Liangshun
   Yang, Hangyu
   Zhang, Chengxian
   Shen, Lianfeng
   Liu, Qiao
   Yan, Haoxiao
   Zhao, Liulan
   Yang, Song
TI Salidroside Promotes Fatty Acid β-Oxidation and Reduces Hepatic Lipid
   Deposition in Largemouth Bass by Activating Autophagy via the AMPK/mTOR
   Pathway
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE Micropterus salmoides; salidroside; high-carbohydratediet; lipid
   deposition; AMPK/mTOR pathway
ID LIVER-DISEASE; METABOLISM; LIPOPHAGY; STRESS; CELLS
AB Replacing expensive fishmeal with economically viable plant-derived carbohydrates in aquafeeds holds significant promise. However, excess dietary carbohydrates can induce hepatosteatosis in fish. This study investigated the effects of salidroside (Sal) supplementation of high-carbohydrate (HC) diets on the growth, hepatic fatty acid oxidation, and lipid metabolism of largemouth bass, Micropterus salmoides. Sal did not enhance growth performance but significantly ameliorated morphological indices in HC-fed fish and markedly reduced hepatic triglycerides (TGs), enhanced lipolysis, and stimulated beta-oxidation of fatty acids. Furthermore, Sal significantly upregulated AMPK alpha phosphorylation while downregulating mTOR phosphorylation, thereby activating autophagy-related gene expression. Pearson correlation analysis indicated a strong association between reduced lipid deposition and the AMPK/mTOR-mediated activation of autophagy. In vitro experiments confirmed that Sal activates autophagy via the AMPK/mTOR pathway, thereby mitigating the high-glucose-induced accumulation of TGs. Thus, Sal alleviates hepatic lipid deposition in largemouth bass by activating the AMPK/mTOR signaling pathway, inducing autophagy, and promoting beta-oxidation of fatty acids. This study provides evidence for Sal's therapeutic potential against piscine fatty liver disease and identifies novel targets for managing pathological lipid deposition in aquaculture species.
C1 [He, Kuo; Cheng, Liangshun; Yang, Hangyu; Zhang, Chengxian; Shen, Lianfeng; Liu, Qiao; Yan, Haoxiao; Zhao, Liulan; Yang, Song] Sichuan Agr Univ, Coll Anim Sci & Technol, Chengdu 611130, Sichuan, Peoples R China.
C3 Sichuan Agricultural University
RP Zhao, LL; Yang, S (corresponding author), Sichuan Agr Univ, Coll Anim Sci & Technol, Chengdu 611130, Sichuan, Peoples R China.
EM zhaoliulan2007@163.com; ysys210@hotmail.com
OI Yang, Song/0000-0003-3209-5641
FU Freshwater Fish Innovation [SCCXTD-2025-15]; Natural Science Foundation
   of Sichuan Province [2024NSFSC2069]
FX <STRONG> </STRONG>This study was supported by the Freshwater Fish
   Innovation (NO. SCCXTD-2025-15), also supported by the Natural Science
   Foundation of Sichuan Province (NO: 2024NSFSC2069).
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NR 72
TC 0
Z9 0
U1 12
U2 29
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD SEP 10
PY 2025
VL 73
IS 36
BP 22466
EP 22484
DI 10.1021/acs.jafc.5c09096
EA AUG 2025
PG 19
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 7DA6N
UT WOS:001560072700001
PM 40866319
DA 2026-05-27
ER

PT J
AU Ji, WW
   Zhang, ZY
   Jin, TY
   Meng, DY
   Zhou, XY
   Hu, J
   Wang, Y
AF Ji, Weiwei
   Zhang, Zengyu
   Jin, Tingyu
   Meng, Danyang
   Zhou, Xuyou
   Hu, Jin
   Wang, Yong
TI Salidroside attenuates cognitive deficits induced by chronic cerebral
   hypoperfusion via modulating microglial phenotypic transformation in
   mice
SO JOURNAL OF NEUROIMMUNOLOGY
LA English
DT Article
DE Salidroside (SLDS); Chronic cerebral hypoperfusion (CCH); Microglial
   polarization; Neuroinflammation; Neuroprotection
ID SEX-DIFFERENCES; INFLAMMATION; STROKE
AB Background: Chronic cerebral hypoperfusion (CCH) is a significant contributor to vascular cognitive impairment (VCI), often linked to cortical and hippocampal damage. This study investigates the therapeutic potential of salidroside (SLDS) in mitigating CCH-induced brain injury by modulating microglial activation and inflammatory responses. Methods: We established a CCH model in mice using the 0.16/0.18 mm bilateral common carotid artery stenosis (BCAS) procedure. We assessed cerebral blood flow (CBF) via laser speckle contrast imaging, while neuropathology was evaluated through Nissl staining and immunofluorescence (IF) experiments. Cognitive deficits were measured using the Morris water maze test. Neuronal apoptosis and neuroinflammation were examined through IF, ELISA, and qRT-PCR. Results: BCAS-induced hypoperfusion resulted in a marked reduction in CBF, increased neuronal apoptosis, and significant cognitive deficits. SLDS treatment effectively countered these effects by shifting microglial polarization from a pro-inflammatory M1 phenotype to an anti-inflammatory M2 phenotype, reducing pro- inflammatory cytokine levels, and enhancing neuronal survival. Conclusion: SLDS demonstrates strong neuroprotective potential against CCH-induced brain injury by reducing inflammation and preventing neuronal apoptosis. These findings highlight the promise of SLDS as a therapeutic agent for chronic cerebrovascular disorders, warranting further investigation into its molecular mechanisms and clinical applicability.
C1 [Ji, Weiwei; Jin, Tingyu; Meng, Danyang; Zhou, Xuyou; Hu, Jin] Jiaxing Univ, Affiliated Hosp, Hosp Jiaxing 1, Dept Neurol, Jiaxing 314000, Peoples R China.
   [Zhang, Zengyu] Fudan Univ, Minhang Hosp, Dept Neurol, Shanghai 201199, Peoples R China.
   [Wang, Yong] Fudan Univ, Zhongshan Hosp, Dept Neurol, Shanghai 200030, Peoples R China.
C3 Jiaxing University; Fudan University; Fudan University
RP Hu, J (corresponding author), Jiaxing Univ, Affiliated Hosp, Hosp Jiaxing 1, Dept Neurol, Jiaxing 314000, Peoples R China.; Wang, Y (corresponding author), Fudan Univ, Zhongshan Hosp, Dept Neurol, Shanghai 200030, Peoples R China.
EM hujin19771110@163.com; yong_wang@fudan.edu.cn
RI Zhang, Zengyu/LJL-3632-2024
OI Zhang, Zengyu/0000-0002-2751-3901
FU Jiaxing Livelihood Science and Technology Innovation Research Fund
   [2023AD31069]; Jiaxing City Supporting Discipline Program in Neurology
   [2023-ZC-006]
FX This work was supported by grants from the Jiaxing Livelihood Science
   and Technology Innovation Research Fund (2023AD31069) , and the Jiaxing
   City Supporting Discipline Program in Neurology (Grant No. 2023-ZC-006)
   .
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NR 33
TC 3
Z9 3
U1 2
U2 8
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0165-5728
EI 1872-8421
J9 J NEUROIMMUNOL
JI J. Neuroimmunol.
PD MAR 15
PY 2025
VL 400
AR 578544
DI 10.1016/j.jneuroim.2025.578544
EA FEB 2025
PG 10
WC Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology
GA X0U5N
UT WOS:001422608200001
PM 39908941
OA hybrid
DA 2026-05-27
ER

PT J
AU Chiang, HM
   Chen, HC
   Wu, CS
   Wu, PY
   Wen, KC
AF Chiang, Hsiu-Mei
   Chen, Hsin-Chun
   Wu, Chin-Sheng
   Wu, Po-Yuan
   Wen, Kuo-Ching
TI Rhodiola plants: Chemistry and biological activity
SO JOURNAL OF FOOD AND DRUG ANALYSIS
LA English
DT Review
DE bioactivity; Rhodiola; salidroside; tyrosol
ID INDUCED OXIDATIVE STRESS; ROSEA L. EXTRACT; FACTOR-KAPPA-B; AQUEOUS
   EXTRACT; IMBRICATA-RHIZOME; ANTIOXIDANT ACTIVITY; CELLULAR-IMMUNITY;
   IXORA-PARVIFLORA; HERBAL MEDICINES; PROTECTIVE ROLE
AB Rhodiola is a genus of medicinal plants that originated in Asia and Europe and are used traditionally as adaptogens, antidepressants, and anti-inflammatory remedies. Rhodiola plants are rich in polyphenols, and salidroside and tyrosol are the primary bioactive marker compounds in the standardized extracts of Rhodiola rosea. This review article summarizes the bioactivities, including adaptogenic, antifatigue, antidepressant, antioxidant, anti-inflammatory, antinoception, and anticancer activities, and the modulation of immune function of Rhodiola plants and its two constituents, as well as their potential to prevent cardiovascular, neuronal, liver, and skin disorders. Copyright (C) 2015, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC. All rights reserved.
C1 [Chiang, Hsiu-Mei; Chen, Hsin-Chun; Wu, Chin-Sheng; Wen, Kuo-Ching] China Med Univ, Dept Cosmeceut, Taichung 404, Taiwan.
   [Wu, Po-Yuan] China Med Univ Hosp, Dept Dermatol, Taichung 404, Taiwan.
   [Wu, Po-Yuan] China Med Univ, Sch Med, Taichung 404, Taiwan.
C3 China Medical University Taiwan; China Medical University Taiwan; China
   Medical University Hospital - Taiwan; China Medical University Taiwan
RP Wen, KC (corresponding author), China Med Univ, Dept Cosmeceut, 91 Hsueh Shih Rd, Taichung 404, Taiwan.
EM kcwen0412@gmail.com
RI Chiang, Hsiu-Mei/L-8150-2013
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NR 100
TC 155
Z9 186
U1 5
U2 186
PU DIGITAL COMMONS BEPRESS
PI BERKELEY
PA 2100 MILVIA ST, STE 300, BERKELEY, CA 94704 USA
SN 1021-9498
J9 J FOOD DRUG ANAL
JI J. Food Drug Anal.
PD SEP
PY 2015
VL 23
IS 3
BP 359
EP 369
DI 10.1016/j.jfda.2015.04.007
PG 11
WC Food Science & Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Pharmacology & Pharmacy
GA CR3TV
UT WOS:000361256900003
PM 28911692
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Li, WH
   Liu, Q
   Chen, SY
   Zhi, MF
   Yang, P
   Zhang, YX
   Wu, ZY
   Zhang, J
   Feng, Q
AF Li, Wanheng
   Liu, Qing
   Chen, Siyu
   Zhi, Mengfan
   Yang, Peng
   Zhang, Yuxing
   Wu, Zhaoyan
   Zhang, Jun
   Feng, Qiang
TI Salidroside Improves Periodontitis by Mitigating Inflammatory Reactions
   and Enhancing Osteogenic Differentiation of Human Periodontal Ligament
   Stem Cells
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Article
DE periodontitis; salidroside; osteogenesis; the human periodontal ligament
   stem cells
AB Purpose: Salidroside (Sal), a significant bioactive compound found in Rhodiola rosea, is documented to possess various pharmacological properties. This study investigated the effects of Sal in alleviating periodontitis. Methods: The rat periodontitis model was utilized to assess the therapeutic impact of Sal on periodontitis. Human periodontal ligament stem cells (hPDLSCs) were used to investigate the effect of Sal on lipopolysaccharide (LPS)-inhibited osteogenic differentiation. RNA sequencing (RNA-seq), and Western blot were employed to analyze the genes and proteins impacted by Sal treatment. Results: Sal significantly alleviated the alveolar bone loss and gingival inflammation in rats periodontitis model. Sal demonstrated a dose-dependent pattern of promoting osteogenesis on hPDLSCs. A concentration of 0.5 mu M Sal could effectively counteract the impact of LPS on osteogenic differentiation. Mechanically, Sal inhibited the ratios of phospho-I kappa B alpha(p-I kappa B alpha)/I kappa B alpha and phospho-p65 (p-p65)/p65 in Nuclear Factor kappa-B (NF-kappa B) pathway and reduced the expressions of interleukin-6 (IL-6) and interleukin-8 (IL-8). Sal increased the expression of lymphoid enhancer-binding factor 1 (LEF1). Conclusion: Sal promoted the osteogenic differentiation by inhibiting the activation of the NF-kappa B pathway and increasing the expression of LEF1.
C1 [Li, Wanheng; Chen, Siyu; Yang, Peng; Zhang, Yuxing; Wu, Zhaoyan; Zhang, Jun] Shandong Univ, Sch & Hosp Stomatol, Cheeloo Coll Med, Dept Orthodont, 44-1 Wenhua Rd West, Jinan 250012, Shandong, Peoples R China.
   [Li, Wanheng; Chen, Siyu; Zhi, Mengfan; Yang, Peng; Zhang, Yuxing; Wu, Zhaoyan; Zhang, Jun; Feng, Qiang] Shandong Key Lab Oral Tissue Regenerat, 44-1 Wenhua Rd West, Jinan 250012, Shandong, Peoples R China.
   [Li, Wanheng; Chen, Siyu; Zhi, Mengfan; Yang, Peng; Zhang, Yuxing; Wu, Zhaoyan; Zhang, Jun; Feng, Qiang] Shandong Engn Res Ctr Dent Mat & Oral Tissue Regen, 44-1 Wenhua Rd West, Jinan 250012, Shandong, Peoples R China.
   [Li, Wanheng; Chen, Siyu; Zhi, Mengfan; Yang, Peng; Zhang, Yuxing; Wu, Zhaoyan; Zhang, Jun; Feng, Qiang] Shandong Prov Clin Res Ctr Oral Dis, 44-1 Wenhua Rd West, Jinan 250012, Shandong, Peoples R China.
   [Liu, Qing] Taian Matern & Child Care Hosp, Dept Stomatol, Tai An, Peoples R China.
   [Zhi, Mengfan; Feng, Qiang] Shandong Univ, Sch & Hosp Stomatol, Cheeloo Coll Med, Dept Human Microbiome, 44-1 Wenhua Rd West, Jinan 250012, Shandong, Peoples R China.
C3 Shandong University; Shandong University
RP Zhang, J (corresponding author), Shandong Univ, Sch & Hosp Stomatol, Cheeloo Coll Med, Dept Orthodont, 44-1 Wenhua Rd West, Jinan 250012, Shandong, Peoples R China.; Zhang, J; Feng, Q (corresponding author), Shandong Key Lab Oral Tissue Regenerat, 44-1 Wenhua Rd West, Jinan 250012, Shandong, Peoples R China.; Zhang, J; Feng, Q (corresponding author), Shandong Engn Res Ctr Dent Mat & Oral Tissue Regen, 44-1 Wenhua Rd West, Jinan 250012, Shandong, Peoples R China.; Zhang, J; Feng, Q (corresponding author), Shandong Prov Clin Res Ctr Oral Dis, 44-1 Wenhua Rd West, Jinan 250012, Shandong, Peoples R China.; Feng, Q (corresponding author), Shandong Univ, Sch & Hosp Stomatol, Cheeloo Coll Med, Dept Human Microbiome, 44-1 Wenhua Rd West, Jinan 250012, Shandong, Peoples R China.
EM zhangj@sdu.edu.cn; fengqiangsdu@163.com
RI Wu, Zhaoyan/A-1045-2013
OI Chen, Siyu/0009-0009-1592-8112
FU Province Natural Science Foundation of Shandong Province [ZR2021QH340]
FX The study has been supported by the Province Natural Science Foundation
   of Shandong Province, grant numbers ZR2021QH340.
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NR 51
TC 0
Z9 0
U1 4
U2 10
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2025
VL 19
BP 8097
EP 8114
DI 10.2147/DDDT.S530311
PG 18
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 7CB2Q
UT WOS:001567461500001
PM 40955307
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, YX
   Dan, LW
   Tang, JM
   Yin, ZT
   Yang, LZ
   Zhang, DD
   Song, XM
   Wang, W
   Li, YZ
AF Liu, Yaxiao
   Dan, Linwei
   Tang, Jiamei
   Yin, Zitong
   Yang, Longzhu
   Zhang, Dongdong
   Song, Xiaomei
   Wang, Wei
   Li, Yuze
TI Extraction and purification, pharmacological action, synthesis and
   product development of salidroside: a review
SO MEDICINAL CHEMISTRY RESEARCH
LA English
DT Review
DE Salidroside; Extraction and purification; Pharmacological activity;
   Synthesis; Product development
ID RHODIOLA; TYROSOL; ROSEA
AB Salidroside (Sal), a natural phenolic glycoside ubiquitous across all species of the Rhodiola genus, has garnered considerable attention in contemporary pharmacological research. Its multifaceted pharmacological profile encompasses anti-tumor, anti-hypoxia, anti-inflammatory, and anti-atherosclerotic properties, among others. Notably, its pharmacological repertoire extends to safeguarding against hypoxic injury, particularly in high-altitude environments. Furthermore, Sal serves as a key indicator for assessing the quality of Rhodiola. It is capable of exerting biological activity on the nervous system, cardiovascular system and internal organs of the body through various pathways and mechanisms, and thus has the potential to be therapeutically effective in the treatment of diseases associated with these systems. In order to optimize the effectiveness and safety of Sal's application and ensure the isolation of highly pure and stable monomer components, its extraction and purification processes were refined. In addition, it is important to protect wild plant resources and meet market demand, as well as to explore Sal and its synthetic products, in consideration of its anti-altitude anoxia biological characteristics. Therefore, this paper reviewed the source, extraction and purification, pharmacological effects, biological activity, synthesis and product application of Sal, updated and deepened the understanding of Sal, and provided theoretical basis for the further research of Sal.
C1 [Liu, Yaxiao; Dan, Linwei; Tang, Jiamei; Yin, Zitong; Yang, Longzhu; Zhang, Dongdong; Song, Xiaomei; Wang, Wei; Li, Yuze] Shaanxi Univ Chinese Med, Sch Pharm, Shaanxi Key Lab Res & Applicat Taibai Qi Yao, Xianyang, Peoples R China.
C3 Shaanxi University of Chinese Medicine
RP Li, YZ (corresponding author), Shaanxi Univ Chinese Med, Sch Pharm, Shaanxi Key Lab Res & Applicat Taibai Qi Yao, Xianyang, Peoples R China.
EM lyz1990yeah@163.com
FU Shaanxi Provincial Science and Technology Department Project
   [2024JC-YBQN-0860]; Program project for Shaanxi University of Chinese
   Medicine [2021GP27]; Shaanxi University of Chinese Medicine Science and
   Technology Innovation Team Project [2019-YL12]; Sci-Tech Innovation
   Talent System Construction Program of Shaanxi University of Chinese
   Medicine [2023-CXTD-05]; Department of Education of Shaanxi Province
   [22JK0344]
FX The authors are grateful for the Shaanxi Provincial Science and
   Technology Department Project (2024JC-YBQN-0860), Program project for
   Shaanxi University of Chinese Medicine (grant number 2021GP27), Shaanxi
   University of Chinese Medicine Science and Technology Innovation Team
   Project (2019-YL12), Sci-Tech Innovation Talent System Construction
   Program of Shaanxi University of Chinese Medicine (No. 2023-CXTD-05),
   and Department of Education of Shaanxi Province (grant number 22JK0344).
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NR 207
TC 2
Z9 3
U1 14
U2 48
PU SPRINGER BIRKHAUSER
PI NEW YORK
PA 233 SPRING STREET, 6TH FLOOR, NEW YORK, NY 10013 USA
SN 1054-2523
EI 1554-8120
J9 MED CHEM RES
JI Med. Chem. Res.
PD OCT
PY 2024
VL 33
IS 10
BP 1804
EP 1828
DI 10.1007/s00044-024-03306-z
EA SEP 2024
PG 25
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA I2J1R
UT WOS:001307299300001
DA 2026-05-27
ER

PT J
AU Ma, J
   Li, YJ
   Ji, XD
   Wang, AQ
   Lan, Y
   Ma, LH
AF Ma, Jie
   Li, Yujie
   Ji, Xiaodi
   Wang, Anqi
   Lan, Yue
   Ma, Lihong
TI Integrating network pharmacology and experimental verification to
   explore the mechanisms of salidroside against myocardial fibrosis
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Salidroside; Myocardial fibrosis; Network pharmacology; TGF-beta 1/Smad3
   signaling pathway; Wnt/beta-catenin signaling pathway
ID NF-KAPPA-B; TGF-BETA; ACTIVATION; HEART
AB Myocardial fibrosis (MF) is the manifestation of a variety of cardiovascular diseases. Salidroside (SAL) has been proved to have a certain effect on anti-fibrosis in various organs. However, the mechanism of SAL in the treatment of MF remains unclear. Network pharmacology showed that there were 1228 SAL-related target genes and 2793 MF-related target genes. The intersection of these genes resulted in 271 drug-disease interactions, and 15 core active targets were filtered from protein-protein interaction mapping. The top 20 Gene ontology biological processes analysis showed that the involved processes were close to the pathogenesis of MF. Among the top 20 enriched KEGG pathways, Wnt/beta-catenin and TGF-beta 1/Smad3 signaling pathways were identified. In vivo, MI rats exhibited thinning of the myocardial region and the formation of fibrous scars, the expression of smad3 and beta-catenin were increased. After SAL treatment, there was a significant reduction in collagen area and a decrease in the ratio of collagen type I to type III. The expression of smad3 and beta-catenin was suppressed and positively correlated with the dosage of SAL. SAL may contribute to the progression of MF through the TGF-beta 1/Smad3 and Wnt/beta-catenin signaling pathways.
C1 [Ma, Jie; Ji, Xiaodi; Wang, Anqi; Lan, Yue; Ma, Lihong] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing, Peoples R China.
   [Li, Yujie] Changping Dist Hosp Tradit Chinese Med, Beijing, Peoples R China.
   [Li, Yujie] Grad Sch China Acad Chinese Med Sci, Beijing, Peoples R China.
   [Ma, Lihong] Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, State Key Lab Cardiovasc Dis, 167 North Lishi Rd, Beijing 100037, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College; Fu Wai Hospital - CAMS; Chinese Academy of
   Medical Sciences - Peking Union Medical College; Fu Wai Hospital - CAMS;
   Peking Union Medical College
RP Ma, LH (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Fuwai Hosp, State Key Lab Cardiovasc Dis, 167 North Lishi Rd, Beijing 100037, Peoples R China.
EM mlh4463@163.com
OI Ma, Lihong/0009-0004-5497-8845; Lan, Yue/0000-0003-2499-812X; MA,
   Jie/0000-0003-3471-2738
FU National High-Level Hospital Clinical Research Funding [2022-GSP-TS-2]
FX Funding This study was supported by National High-Level Hospital
   Clinical Research Funding (2022-GSP-TS-2) .
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TC 9
Z9 10
U1 0
U2 14
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD OCT 15
PY 2023
VL 677
BP 38
EP 44
DI 10.1016/j.bbrc.2023.07.059
EA AUG 2023
PG 7
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA P7GY3
UT WOS:001052333800001
PM 37544102
DA 2026-05-27
ER

PT J
AU Lv, P
   Zuo, ZF
   Liu, WQ
   Zhao, LP
   Wang, YF
   Wang, XB
   Yu, SX
   Yu, HD
   Zhang, TY
   Bi, J
   Liu, XZ
AF Lv, Pan
   Zuo, Zhongfu
   Liu, Wenqiang
   Zhao, Lipan
   Wang, Yufei
   Wang, Xiaobai
   Yu, Shengxue
   Yu, Hongdan
   Zhang, Tianyi
   Bi, Jing
   Liu, Xuezheng
TI Salidroside Alleviates Diabetic Cognitive Dysfunction Via
   B3galt2/F3/Contactin Signaling Pathway in Mice
SO NEUROSCIENCE
LA English
DT Article
DE salidroside; b-1; 3-galactosyltransferase 2; F3; Contactin; cognitive
   dysfunction; diabetes; apoptosis
ID SYNAPTIC PLASTICITY; F3/CONTACTIN; MEMORY; APOPTOSIS;
   GLYCOSYLTRANSFERASES; INFLAMMATION; ASSOCIATION; HIPPOCAMPUS;
   ACTIVATION; EXPRESSION
AB Diabetes is frequently accompanied by cognitive impairment with insidious onset, and progressive cognitive and behavioral changes. b-1, 3-galactosyltransferase 2 (B3galt2) contributes to glycosylation, showing a clue for neuronal apoptosis, proliferation and differentiation. However, the role of B3galt2 in diabetic cognitive dysfunction (DCD) has not been investigated. In the present study, we aimed to explore the role of B3galt2 in DCD. Additionally, the potential therapeutic effects of salidroside on DCD was also explored. Diabetic C57BL/6J mice showed cognitive dysfunction together with down-regulated B3galt2. Overexpression of B3galt2 reversed the cognitive decline of diabetic C57BL/6J. Moreover, cognitive impairment was aggravated in B3galt2+/- diabetic mice compared with C57BL/6J diabetic mice. Immunohistochemistry fluorescence indicated that B3galt2 and F3/Contactin were co-localized in the hippocampal regions. Importantly, the expression of F3/Contactin can be regulated by the manipulation of B3galt2, overexpression of which assuaged hippocampal neuronal damage, pro-tected the synapsin, and reduced neuronal apoptosis in diabetic mice. Interestingly, SAL alleviated DCD and reversed the expression of B3galt2 in diabetic C57BL/6J mice. These findings indicate that inhibition of B3-galt2/F3/Contactin pathway contributes to DCD, and participates in SAL reversed DCD.(c) 2023 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Lv, Pan; Zuo, Zhongfu; Liu, Wenqiang; Zhao, Lipan; Wang, Yufei; Wang, Xiaobai; Zhang, Tianyi; Liu, Xuezheng] Jinzhou Med Univ, Dept Anat Histol & Embryol, Jinzhou, Peoples R China.
   [Zuo, Zhongfu; Yu, Shengxue; Yu, Hongdan; Liu, Xuezheng] Jinzhou Med Univ, Dept Anat Histol & Embryol, Liaoning Key Lab Diabetic Cognit & Percept Dysfunc, Jinzhou, Peoples R China.
   [Zuo, Zhongfu] Guangxi Med Univ, Dept Anat Histol & Embryol, Postdoctoral Res Stn, Nanning, Peoples R China.
   [Bi, Jing] Jinzhou Med Univ, Dept Neurobiol, Jinzhou, Liaoning, Peoples R China.
   [Bi, Jing] Jinzhou Med Univ, Key Lab Neurodegenerat Dis Liaoning Prov, Jinzhou, Liaoning, Peoples R China.
C3 Jinzhou Medical University; Jinzhou Medical University; Guangxi Medical
   University; Jinzhou Medical University; Jinzhou Medical University
RP Liu, XZ (corresponding author), Jinzhou Med Univ, Dept Anat Histol & Embryol, Jinzhou, Peoples R China.; Bi, J (corresponding author), Jinzhou Med Univ, Dept Neurobiol, Jinzhou, Liaoning, Peoples R China.; Bi, J (corresponding author), Jinzhou Med Univ, Key Lab Neurodegenerat Dis Liaoning Prov, Jinzhou, Liaoning, Peoples R China.
EM jing_b@jzmu.edu.cn; liuxuezheng168@vip.sina.com
RI ZHANG, TIANYI/HTN-9050-2023
FU China Postdoctoral Science Foundation [2017M612870]; Natural Science
   Foundation of Liaoning Province [2019-ZD-0807]
FX Funding This work was supported by grants from China Postdoctoral
   Science Foundation (No. 2017M612870) and Natural Science Foundation of
   Liaoning Province (No. 2019-ZD-0807) .
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NR 50
TC 10
Z9 13
U1 1
U2 24
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD FEB 21
PY 2023
VL 512
BP 47
EP 58
DI 10.1016/j.neuroscience.2022.12.008
EA JAN 2023
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 8N6VP
UT WOS:000925287500001
PM 36509381
DA 2026-05-27
ER

PT J
AU You, SX
   Ma, ZY
   Zhang, P
   Xu, WW
   Zhan, CS
   Sang, NA
   Xu, JZ
   Wang, FY
   Zhang, JE
AF You, Suxin
   Ma, Zhouyun
   Zhang, Pei
   Xu, Wenwen
   Zhan, Changsen
   Sang, Nina
   Xu, Jiazhen
   Wang, Feiyun
   Zhang, Jiange
TI Neuroprotective effects of the salidroside derivative SHPL-49 via the
   BDNF/TrkB/Gap43 pathway in rats with cerebral ischemia
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Salidroside derivative; BDNF; Microglia; Polarization; Neuroprotection
ID NEUROTROPHIC FACTORS; SYNAPSE FORMATION; STROKE; BRAIN; POLARIZATION;
   RECOVERY; EXPANSION; INJURY
AB Ischemic stroke is a common intravascular disease and one of the leading causes of death and disability. The salidroside derivative SHPL-49, which we previously synthesized, significantly attenuates cerebral ischemic injury in a rat model of permanent middle cerebral artery occlusion. To explore the neuroprotective mechanism of SHPL-49, the effects of SHPL-49 on the expression levels of neurotrophic factors in neurons and microglia and the polarization of microglia were investigated in the present study. SHPL-49 activated the brain-derived neurotrophic factor (BDNF) pathway, decreased the number of degenerated neurons, and accelerated neurogenesis in rats with cerebral ischemia. In addition, SHPL-49 promoted the polarization of microglia toward the M2 phenotype to alleviate neuroinflammation. In BV2 cells, SHPL-49 upregulated CD206 mRNA and protein levels and inhibited CD86 mRNA and protein levels. SHPL-49 also increased neurotrophic factor secretion in BV2 cells, which indirectly promoted the survival of primary neurons after oxygen-glucose deprivation (OGD). Proteomics analysis revealed that SHPL-49 promoted growth-associated protein 43 (Gap43) expression. SHPL-49 enhanced synaptic plasticity and increased Gap43 protein levels via activation of the BDNF pathway in the OGD primary neuron model. These results indicate that SHPL-49 prevents cerebral ischemic injury by activating neurotrophic factor pathways and altering microglial polarization. Thus, SHPL-49 is a potential neuroprotective agent.
C1 [You, Suxin; Ma, Zhouyun; Zhang, Pei; Sang, Nina; Xu, Jiazhen; Wang, Feiyun; Zhang, Jiange] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit, Res Ctr Chiral Drugs, Chinese Med IRI, Shanghai 201203, Peoples R China.
   [Xu, Wenwen; Zhan, Changsen] Shanghai Hutchison Pharmaceut Co Ltd, Shanghai 201203, Peoples R China.
   [Zhang, Jiange] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med IRI, Shanghai 201203, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Zhang, JE (corresponding author), Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med IRI, Shanghai 201203, Peoples R China.
EM jgzhang@shutcm.edu.cn
RI Xu, Wenwen/AAD-9116-2019
FU Shanghai Frontiers Science Center for Traditional Chinese Medicine
   Chemical Biology; Shanghai Science and Technology Development Fund from
   Central Leading Local Government [YDZX20223100001004]; The "2020
   Shanghai science and technology innovation action plan" biomedical
   science and technology support for special projects [20S11904400];
   Traditional Chinese and Western Medicine Collaborative Guidance Project
   of Integrated Hospital from Shanghai Municipal Health
   Commission/Shanghai Municipal Administration of Traditional Chinese
   Medicine [ZXXT-202303]; Open Project of National Major Scientific and
   Technological Infrastructure for Translational Medicine (Shanghai)
   [TMSK-2021-405]
FX <STRONG> </STRONG>This work was supported by grants from Shanghai
   Frontiers Science Center for Traditional Chinese Medicine Chemical
   Biology, Shanghai Science and Technology Development Fund from Central
   Leading Local Government (YDZX20223100001004) , "2020 Shanghai science
   and technology innovation action plan" biomedical science and technology
   support for special projects (20S11904400) , Traditional Chinese and
   Western Medicine Collaborative Guidance Project of Integrated Hospital
   from Shanghai Municipal Health Commission/Shanghai Municipal
   Administration of Traditional Chinese Medicine (ZXXT-202303) and Open
   Project of National Major Scientific and Technological Infrastructure
   for Translational Medicine (Shanghai) (TMSK-2021-405) .
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NR 59
TC 21
Z9 23
U1 3
U2 17
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAY
PY 2024
VL 174
AR 116460
DI 10.1016/j.biopha.2024.116460
EA MAR 2024
PG 14
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA PT6H1
UT WOS:001216369500001
PM 38520864
OA gold
DA 2026-05-27
ER

PT J
AU Yang, L
   Mao, BY
   Liu, N
AF Yang, Lei
   Mao, Bingyu
   Liu, Nuan
TI Angiogenesis function of salidroside in myocardium of rats with
   myocardial ischemia
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Article
DE Salidroside; myocardial infarction; angiogenesis; vascular endothelial
   growth factors; CD34
ID INFARCTION; EXPRESSION; THERAPY; CELLS; STEM
AB This study is to determine the effect of salidroside (SAL) on myocardium of rats with myocardial infarction (MI) and to analyze its possible mechanism. Left coronary artery of Sprague-Dawley rats was ligated to establish MI model. The rats were randomly divided into model group, SAL groups (10, 20, and 40 mg/(kg/d) groups), and the sham-operated group, with 8 rats per group. Hemodynamic changes in rats were determined, and the segmental heart samples were used for H&E or Masson staining. Expression of vascular endothelial growth factors (VEGF) and cluster of differentiation 34 (CD34) were analyzed by semi-quantitative PCR and Western blot. Compared with the sham-operated group, myocardial tissue was damaged and the collagen volume fraction was significantly increased (P<0.01). Compared with the model group, the number of angiogenesis in all the SAL treatment groups was significantly increased while the collagen volume fraction was significantly decreased (P<0.01). In addition, mRNA and protein levels of VEGF and CD34 in the cytoplasm of SAL treated myocardial tissues were significantly increased compared with the model group (P<0.01). SAL can obviously promote angiogenesis in myocardial tissue of rats after MI.
C1 [Yang, Lei; Mao, Bingyu; Liu, Nuan] Nanyang Inst Technol, Ctr Med Expt, 80 Changjiang Rd, Nanyang 473004, Henan Province, Peoples R China.
C3 Nanyang Institute of Technology
RP Mao, BY (corresponding author), Nanyang Inst Technol, Ctr Med Expt, 80 Changjiang Rd, Nanyang 473004, Henan Province, Peoples R China.
EM Bingyumao2014@126.com
FU National Natural Science Foundation of China [81473438, U160411421,
   81202791]; Science and Technology Project of Henan Province
   [162102310011]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81473438, No. U160411421, and No. 81202791), and the Science
   and Technology Project of Henan Province (No. 162102310011).
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NR 17
TC 0
Z9 2
U1 0
U2 5
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2017
VL 10
IS 3
BP 4957
EP 4962
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA ET8MG
UT WOS:000400552900079
DA 2026-05-27
ER

PT J
AU Feng, J
   Zhang, QH
   Mo, WH
   Wu, LW
   Li, SN
   Li, JJ
   Liu, T
   Xu, SZ
   Fan, XM
   Guo, CY
AF Feng, Jiao
   Zhang, Qinghui
   Mo, Wenhui
   Wu, Liwei
   Li, Sainan
   Li, Jingjing
   Liu, Tong
   Xu, Shizan
   Fan, Xiaoming
   Guo, Chuanyong
TI Salidroside pretreatment attenuates apoptosis and autophagy during
   hepatic ischemia-reperfusion injury by inhibiting the mitogen-activated
   protein kinase pathway in mice
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Article
DE liver injury; salidroside; apoptosis; autophagy; JNK; P38
ID ISCHEMIA/REPERFUSION INJURY; MOLECULAR-MECHANISMS; CELL-DEATH; LIVER;
   BCL-2; NECROPTOSIS; ALPHA; MAPK; RATS; JNK
AB Ischemia-reperfusion injury (IRI) contributes to liver damage in many clinical situations, such as liver resection and liver transplantation. In the present study, we investigated the effects of the antioxidant, anti-inflammatory, and anticancer agent salidroside (Sal) on hepatic IRI in mice. The mice were randomly divided into six groups: normal control, Sham, Sal (20 mg/kg), IRI, IRI + Sal (10 mg/kg), and IRI + Sal (20 mg/kg). We measured liver enzymes, proinflammatory cytokines, TNF-alpha and interleukin-6, and apoptosis- and autophagy-related marker proteins at 2, 8, and 24 hours after reperfusion. Components of mitogen-activated protein kinase (MAPK) signaling, including P-38, jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK), were also measured using an MAPK activator anisomycin to deduce their roles in hepatic IRI. Our results show that Sal safely protects hepatocytes from IRI by reducing levels of liver enzymes in the serum. These findings were confirmed by histopathology. We concluded that Sal protects hepatocytes from IRI partly by inhibiting the activation of MAPK signaling, including the phosphorylation of P38, JNK, and ERK. This ameliorates inflammatory reactions, apoptosis, and autophagy in the mouse liver.
C1 [Feng, Jiao; Wu, Liwei; Li, Sainan; Li, Jingjing; Liu, Tong; Guo, Chuanyong] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Gastroenterol, 301 Middle Yanchang Rd, Shanghai 200072, Peoples R China.
   [Zhang, Qinghui] Jiangsu Univ, Kunshan Peoples Hosp 1, Dept Clin Lab, Kunshan, Jiangsu, Peoples R China.
   [Mo, Wenhui] Fudan Univ, Minhang Hosp, Dept Gastroenterol, Shanghai, Peoples R China.
   [Xu, Shizan] Nanjing Med Univ, Sch Clin Med, Shanghai Peoples Hosp 10, Dept Gastroenterol, Shanghai, Peoples R China.
   [Fan, Xiaoming] Fudan Univ, Jinshan Hosp, Depat Gastroenterol, 1508 Longhang Rd, Shanghai 201508, Peoples R China.
C3 Tongji University; Jiangsu University; Fudan University; Nanjing Medical
   University; Fudan University
RP Guo, CY (corresponding author), Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Gastroenterol, 301 Middle Yanchang Rd, Shanghai 200072, Peoples R China.; Fan, XM (corresponding author), Fudan Univ, Jinshan Hosp, Depat Gastroenterol, 1508 Longhang Rd, Shanghai 201508, Peoples R China.
EM xiaomingfan57@hotmail.com; guochuanyong@hotmail.com
RI Feng, Jiao/AFS-6380-2022
OI Feng, Jiao/0000-0001-5344-7242; Guo, Chuanyong/0000-0002-6527-4673; ,
   Liwei/0000-0003-0322-722X; Li, Sainan/0000-0002-1880-6294
FU National Natural Science Foundation of China [81670472]
FX This work was supported by the National Natural Science Foundation of
   China (grant numbers 81670472). We are grateful to Dr Wenwen Wang, Xiya
   Lu, Qiang Yu, Kan Chen, Yujing Xia, Jie Lu, Ling Xu, and Yingqun Zhou.
   They helped us a lot in the experiment process and data collection. Jiao
   Feng, Qinghui Zhang and Wenhui Mo shared first authorship for this
   study.
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NR 48
TC 55
Z9 62
U1 1
U2 14
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2017
VL 11
BP 1989
EP 2006
DI 10.2147/DDDT.S136792
PG 18
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA EZ7EL
UT WOS:000404884000001
PM 28721018
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yang, RL
   Li, N
   Zong, MH
AF Yang, Rong-Ling
   Li, Ning
   Zong, Min-Hua
TI Using ionic liquid cosolvents to improve enzymatic synthesis of
   arylalkyl β-D-glucopyranosides
SO JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC
LA English
DT Article
DE Ethylene glycol diacetate; beta-Glucosidase; Glycosides; Ionic liquids;
   Reverse hydrolysis; Salidroside
ID APPLE SEED MEAL; CATALYZED SYNTHESIS; REVERSE HYDROLYSIS; BIOCATALYSIS;
   GLYCOSIDES; SYSTEMS; GREEN; GLUCOSIDASE; ALCOHOLS; YIELD
AB Enzymatic synthesis of various arylalkyl beta-D-glucopyranosides catalyzed by prune (Prunus domestica) seed meal via reverse hydrolysis in the mixture of organic solvent, ionic liquid (IL) and phosphate buffer was described. Among four hydrophilic organic solvents tested, ethylene glycol diacetate (EGDA) was found to be the most suitable for enzymatic synthesis of salidroside, a bioactive compound of commercial interest, from D-glucose and tyrosol. The effects of the nature of ionic liquids and their contents on the enzymatic glucosylation were studied. The addition of a suitable amount of ILs including denaturing ones was favorable to shift the reaction equilibrium toward the synthesis, thus improving the yields. Among the examined ILs, the novel IL [BMIm]I proved to be the best. And this IL was applied as the solvent in biocatalysis for the first time. The yields were found to be enhanced between 0.2-fold and 0.5-fold after the addition of 10% (v/v) [BMIm]I. In 10% (v/v) [BMIm]I-containing system, the desired arylalkyl beta-D-glucopyranosides were synthesized with 15-28% yields, among which salidroside was obtained with a yield of 22%. (C) 2011 Elsevier B.V. All rights reserved.
C1 [Yang, Rong-Ling; Li, Ning; Zong, Min-Hua] S China Univ Technol, State Key Lab Pulp & Paper Engn, Coll Light Ind & Food Sci, Guangzhou 510640, Guangdong, Peoples R China.
C3 South China University of Technology
RP Li, N (corresponding author), S China Univ Technol, State Key Lab Pulp & Paper Engn, Coll Light Ind & Food Sci, Guangzhou 510640, Guangdong, Peoples R China.
EM lining@scut.edu.cn; btmhzong@scut.edu.cn
RI Li, Ning/I-3417-2012
OI Li, Ning/0000-0003-1684-4454
FU National Natural Science Foundation of China [20906032, 20876059,
   21072065]; SCUT [2009zz0018, 2009zz0026, 2009zm0199]; State Key
   Laboratory of Pulp and Paper Engineering, SCUT [200913]; Academy of
   Finland (AKA) [200913] Funding Source: Academy of Finland (AKA)
FX This work was financially supported by the National Natural Science
   Foundation of China (Grant no. 20906032, 20876059 and 21072065), the
   Fundamental Research Funds for the Central Universities, SCUT (Grant no.
   2009zz0018, 2009zz0026 and 2009zm0199), and the Open Project Program of
   State Key Laboratory of Pulp and Paper Engineering, SCUT (Grant no.
   200913).
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NR 29
TC 26
Z9 30
U1 1
U2 39
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1381-1177
J9 J MOL CATAL B-ENZYM
JI J. Mol. Catal. B-Enzym.
PD JAN
PY 2012
VL 74
IS 1-2
BP 24
EP 28
DI 10.1016/j.molcatb.2011.08.009
PG 5
WC Biochemistry & Molecular Biology; Chemistry, Physical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 856AZ
UT WOS:000297609900005
DA 2026-05-27
ER

PT J
AU Ni, SY
   Wang, N
   Luo, DY
   Hou, YS
   Li, QY
   Chai, T
   Zheng, YD
   Bu, XS
   Zhu, EJ
   Shi, XF
   Meng, XH
   Wang, XR
   Yang, JL
AF Ni, Shu-Yang
   Wang, Nan
   Luo, De-Yi
   Hou, Yong-Sheng
   Li, Qiu-Yang
   Chai, Tian
   Zheng, Yi-Dan
   Bu, Xing-Sheng
   Zhu, En-Jie
   Shi, Xiao-Feng
   Meng, Xian-Hua
   Wang, Xing-Rong
   Yang, Jun-Li
TI Discovery of novel salidroside derivatives as potent hypoxia inducible
   factor 1α (HIF-1α) signaling inhibitors to treat high altitude cerebral
   edema
SO EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
LA English
DT Article
DE Hypoxia-inducible factor-1 alpha; Salidroside; High altitude cerebral
   edema; Anti-inflammation; o rtho -fluorophenyl
AB High altitude cerebral edema (HACE) represents a potentially lethal manifestation of acute mountain sickness, associated with abnormal activation of hypoxia-inducible factor-1 alpha (HIF-1 alpha) and NF-kappa B inflammation pathway. Based on ortho-fluorophenyl pharmacophore and scaffold-hopping strategy, we designed and synthesized fortythree salidroside derivatives as HIF-1 alpha inhibitors. Dual-luciferase reporter assay demonstrated that compound N41 exhibited the strongest HIF-1 alpha inhibitory activity in HEK293T cells with an IC50 value of 2.02 +/- 0.76 mu M. Meanwhile, N41 significantly suppressed the expression of inflammation factors of IL-6 and NO, as well as the accumulation of ROS without obvious cytotoxicity in C8-D1A cells. The in vivo study revealed that compound N41 could reduce brain water content and oxidative stress level in MDA/SOD measurements. In immunofluorescence assay, N41 suppressed inflammatory expression of IL-6, TNF-alpha, and blood-brain barrier permeability protein AQP-4. Furthermore, the western blotting assay and HE staining demonstrated that N41 regulated the inflammation process in a dose-dependent manner to alleviate cerebral edema in the HACE mouse model. These findings highlighted that compound N41 could effectively target HIF-1 alpha/IKK alpha/NF-kappa B signaling pathway to mitigate pathological inflammation in vivo, providing a new strategy for anti-HACE drug research.
C1 [Ni, Shu-Yang; Hou, Yong-Sheng; Chai, Tian; Zheng, Yi-Dan; Zhu, En-Jie; Meng, Xian-Hua; Wang, Xing-Rong; Yang, Jun-Li] Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China.
   [Ni, Shu-Yang; Hou, Yong-Sheng; Chai, Tian; Zheng, Yi-Dan; Zhu, En-Jie; Meng, Xian-Hua; Wang, Xing-Rong; Yang, Jun-Li] Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China.
   [Ni, Shu-Yang; Zhu, En-Jie] Chinese Acad Sci, Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
   [Wang, Nan; Li, Qiu-Yang; Bu, Xing-Sheng] Gansu Univ Tradit Chinese Med, Coll Pharm, Lanzhou 730000, Peoples R China.
   [Luo, De-Yi] Lanzhou Univ Technol, Sch Life Sci & Engn, Lanzhou 730000, Peoples R China.
   [Shi, Xiao-Feng] Gansu Prov Acad Med Sci & Gansu Prov Canc Hosp, Inst Mat Med, Lanzhou 730000, Peoples R China.
C3 Chinese Academy of Sciences; Lanzhou Institute of Chemical Physics, CAS;
   Chinese Academy of Sciences; Lanzhou Institute of Chemical Physics, CAS;
   Chinese Academy of Sciences; University of Chinese Academy of Sciences,
   CAS; Gansu University of Chinese Medicine; Lanzhou University of
   Technology
RP Wang, XR; Yang, JL (corresponding author), Chinese Acad Sci, Lanzhou Inst Chem Phys, CAS Key Lab Chem Northwestern Plant Resources, Lanzhou 730000, Peoples R China.; Wang, XR; Yang, JL (corresponding author), Chinese Acad Sci, Lanzhou Inst Chem Phys, Key Lab Nat Med Gansu Prov, Lanzhou 730000, Peoples R China.
EM wangxr@licp.cas.cn; yangjl@licp.cas.cn
OI hou, yongsheng/0009-0006-3943-4481; wang, xing-rong/0000-0001-9838-1902
FU National Natural Science Foundation of China [32270419, 2023ZD0505300];
   National Key Research and Development Program [2024YFC3505603]; Lanzhou
   Youth Science and Technology Talent Innovation Project [2024-QN-52];
   Major Program of the Lanzhou Institute of Chemical Physics, CAS
   [ZYFZFX-6]; International Partnership Program of Chinese Academy of
   Sciences [037GJHZ2023043FN]
FX <STRONG>The work was supported by National Natural Science Foundation of
   China (32270419) , the Science and Technology Innovation 2030 Major
   Program (2023ZD0505300) , National Key Research and Development
   </STRONG>Program (2024YFC3505603) , Lanzhou Youth Science and Technology
   Talent Innovation Project (2024-QN-52) , Major Program of the Lanzhou
   Institute of Chemical Physics, CAS (ZYFZFX-6) , and International
   Partnership Program of Chinese Academy of Sciences, Grant No.
   037GJHZ2023043FN.
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NR 46
TC 2
Z9 2
U1 10
U2 25
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0223-5234
EI 1768-3254
J9 EUR J MED CHEM
JI Eur. J. Med. Chem.
PD NOV 5
PY 2025
VL 297
AR 117982
DI 10.1016/j.ejmech.2025.117982
EA JUL 2025
PG 22
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy
GA 5OL0Y
UT WOS:001540517000001
PM 40706447
DA 2026-05-27
ER

PT J
AU Liu, JX
   Cai, JP
   Zhang, NS
   Tai, JD
   Fan, P
   Dong, X
   Cao, YG
AF Liu, Jiuxi
   Cai, Jiapei
   Zhang, Naisheng
   Tai, Jiandong
   Fan, Peng
   Dong, Xue
   Cao, Yongguo
TI Salidroside protects mice from high-fat diet-induced obesity by
   modulating the gut microbiota
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Salidroside; Obesity; Fecal microbiota transplantation; Gut microbiota
ID INSULIN-RESISTANCE; INFLAMMATION; INJURY; CELLS
AB Obesity is a systemic disease with multisystem inflammation associated with gut dysbiosis. Salidroside (SAL) which is a major glycoside extracted from Rhodiola rosea L. has a wide range of pharmacological effects, but the role of gut microbiota in the protective effects of SAL on obesity has not been studied. Herein, we aim to explore whether SAL could ameliorate high-fat diet (HFD)-induced obesity in mice by modulating microbiota. Results showed that oral treatment with SAL alleviated HFD-induced obesity in mice as evidenced by body weight and fat weight. SAL supplementation effectively attenuated fat accumulation, lipid synthesis genes expression, liver inflammation, and metabolic endotoxemia. In addition, SAL treatment alleviated intestinal damage and increased the expression of mucin protein (Mucin-2) and tight junction (TJ) proteins (Occludin and Zonula Occludens-1). 16S rRNA sequencing analysis revealed that the gut microbiota of obese mice was also partly improved by SAL via restoring the microbial community structure and diversity. A fecal microbiota trans-plantation (FMT) study was designed to verify the causality. Compared with fecal transplantation (FM) from the HFD-treated mice, FM from the SAL-treated mice significantly mitigate the symptoms of obese mice, including decreasing body weight, fat accumulation, and attenuating pathological damage in the gut. Thus, SAL could be a remarkable candidate to prevent obesity.
C1 [Liu, Jiuxi; Cai, Jiapei; Zhang, Naisheng; Fan, Peng; Dong, Xue; Cao, Yongguo] Jilin Univ, Coll Vet Med, Dept Clin Vet Med, Changchun 130062, Peoples R China.
   [Liu, Jiuxi] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, Guangzhou 510530, Peoples R China.
   [Tai, Jiandong] First Hosp Jilin Univ, Dept Colorectal & Anal Surg, Changchun 130021, Peoples R China.
   [Cao, Yongguo] Jilin Univ, Coll Vet Med, Key Lab Zoonosis Res, Minist Educ, Changchun 130062, Peoples R China.
C3 Jilin University; Chinese Academy of Sciences; Guangzhou Institute of
   Biomedicine & Health, CAS; Jilin University; Jilin University
RP Cao, YG (corresponding author), Jilin Univ, Coll Vet Med, Dept Clin Vet Med, Changchun 130062, Peoples R China.; Tai, JD (corresponding author), First Hosp Jilin Univ, Dept Colorectal & Anal Surg, Changchun 130021, Peoples R China.
EM taijd@jlu.edu.cn; ygcao82@jlu.edu.cn
RI Fan, Peng/OIS-5642-2025
OI yongguo, Cao/0000-0002-9533-7516
FU Ministry of Science and Technology of the People's Republic of China
   [2016YFD0501009]
FX Funding This study was supported by the Ministry of Science and
   Technology of the People's Republic of China (Grant Number
   2016YFD0501009) .
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NR 45
TC 17
Z9 18
U1 2
U2 39
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD JUL
PY 2023
VL 120
AR 110278
DI 10.1016/j.intimp.2023.110278
EA MAY 2023
PG 12
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA I9EG7
UT WOS:001005733900001
PM 37192552
DA 2026-05-27
ER

PT J
AU Pi, GL
   Cheng, LH
   Li, BF
   Ming, F
AF Pi, Guo-liang
   Cheng, Liang-hao
   Li, Bin-feng
   Ming, Fei
TI Salidroside Enhances the Sensitivity of Lung Cancer Cells to Paclitaxel
   by Regulating the Wnt/β-catenin Signaling Pathway
SO CURRENT MEDICAL SCIENCE
LA English
DT Article
DE Lung cancer; Salidroside; Drug resistance; Paclitaxel; Wnt/beta-catenin
ID PROLIFERATION; MIGRATION
AB ObjectiveChemoresistance, such as paclitaxel (PTX) resistance, has become a great obstacle in non-small cell lung cancer (NSCLC) treatment. The natural agent salidroside (SAL) has been shown to exert an antitumor effect on NSCLC. Nonetheless, it is unclear whether SAL can decrease the resistance of NSCLC to PTX.MethodsPTX-resistant NSCLC cells (H1299/PTX and A549/PTX) were generated. Cell Counting Kit-8 (CCK-8) assay was used to detect cell viability. Colony formation assay and flow cytometry were utilized to assess cell proliferation and apoptosis, respectively. Immunofluorescence staining and TOP/FOP flash luciferase assay were employed to estimate beta-catenin activation. Western blotting was implemented to estimate the protein levels of apoptosis-, proliferation-, and Wnt/beta-catenin signaling-associated markers. A xenograft mouse model was established to investigate the impact of SAL on PTX resistance in vivo.ResultsSAL increased PTX-induced suppression of proliferation and promoted apoptosis in PTX-resistant NSCLC cells. SAL blocked the Wnt/beta-catenin signaling in A549/PTX cells and in tumor-bearing mice. Activating Wnt/beta-catenin signaling reversed the SAL-mediated increase in the sensitivity of NSCLC cells to PTX. SAL attenuated PTX resistance in NSCLC in the xenograft mouse model.ConclusionSAL enhances the sensitivity of NSCLC cells to PTX by blocking the Wnt/beta-catenin signal transduction.
C1 [Pi, Guo-liang] Huazhong Univ Sci & Technol, Hubei Canc Hosp, Tongji Med Coll, Dept Radiat Oncol, Wuhan 430079, Peoples R China.
   [Cheng, Liang-hao; Li, Bin-feng; Ming, Fei] Huazhong Univ Sci & Technol, Hubei Canc Hosp, Tongji Med Coll, Dept Thorac Surg, Wuhan 430079, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Li, BF; Ming, F (corresponding author), Huazhong Univ Sci & Technol, Hubei Canc Hosp, Tongji Med Coll, Dept Thorac Surg, Wuhan 430079, Peoples R China.
EM piguoliang_2004@163.com; libinfengdr@hotmail.com;
   blackpaul2000@hotmail.com
FU Scientific Research Project of Hubei Cancer Hospital [2024HBCHYN08];
   Natural Science Foundation of Hubei Province [2023AFB988]; Scientific
   Research Project in the Field of Oncology [FB2024025225]; Talent Project
   of Hubei Cancer Hospital [2025HBCHHHRC007]
FX The study was supported by the Scientific Research Project of Hubei
   Cancer Hospital (No. 2024HBCHYN08); the Natural Science Foundation of
   Hubei Province (No. 2023AFB988); the Scientific Research Project in the
   Field of Oncology (No. FB2024025225); the Talent Project of Hubei Cancer
   Hospital (No. 2025HBCHHHRC007).
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NR 27
TC 1
Z9 1
U1 2
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2096-5230
EI 2523-899X
J9 CURR MED SCI
JI Curr. Med. Sci.
PD FEB
PY 2025
VL 45
IS 1
BP 104
EP 113
DI 10.1007/s11596-025-00005-7
EA FEB 2025
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA 0CX5B
UT WOS:001433459100001
PM 40014194
DA 2026-05-27
ER

PT J
AU Lyu, X
   Song, WH
   Yu, CQ
   Wang, DW
   Wang, B
   Di, GH
AF Lyu, Xue
   Song, Wenhui
   Yu, Chaoqun
   Wang, Daiwei
   Wang, Bin
   Di, Guohu
TI Salidroside alleviates acute liver injury through mitochondrial
   protection and anti-oxidative effects
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
LA English
DT Review
DE Salidroside; acute liver injury; oxidative injury; hydrogen peroxide;
   carbon tetrachloride; hepatoprotective; L-02 cells
ID OXIDATIVE STRESS; DAMAGE; ACTIVATION; CANCER; ROS
AB Accumulating evidence has indicated the anti-oxidative and anti-inflammatory effect of salidroside (SAL) on acute liver injury; however, the cytoprotection and underlying mechanisms of SAL remained elusive. The aim of our present research was to evaluate the hepatoprotective effect of SAL through carbon tetrachloride (CCl4)induced hepatic injury model and H2O2-induced oxidative injury model in a normal human liver cell line L-02. In vivo, the results revealed that SAL reduced serum alanine aminotransferase (ALT) and alanine aminotransferase (AST) levels, accompanied with ameliorated histopathological changes. In vitro, SAL increased cell viability, inhibited cell apoptosis, reduced reactive oxygen species (ROS) production and recovered mitochondrial membrane potential when compared to the H2O2, group. In addition, SAL treatment up-regulated the expressions of antioxidant-related genes including hemeoxygenase-1 (HO-1), nuclear factor erythroid 2 related factor (Nrf2), manganese superoxide dismutase (Mn-SOD) and catalase (CAT), and down-regulated NADPH oxidase isoform 2 (NOX-2). Taken together, these results demonstrated that SAL could relieve CCl4-induced liver damage and H2O2-induced oxidative injury by mitochondrial protection and oxidative stress suppression, suggesting that SAL could be a potential agent for treating or preventing acute liver injury.
C1 [Lyu, Xue; Yu, Chaoqun; Wang, Bin; Di, Guohu] Qingdao Univ, Sch Basic Med, Dept Special Med, 308 Ningxia Rd, Qingdao 266071, Shandong, Peoples R China.
   [Song, Wenhui; Wang, Daiwei] Qingdao Univ, Sch Med, Qingdao, Shandong, Peoples R China.
C3 Qingdao University; Qingdao University
RP Wang, B; Di, GH (corresponding author), Qingdao Univ, Sch Basic Med, Dept Special Med, 308 Ningxia Rd, Qingdao 266071, Shandong, Peoples R China.
EM wangbin532@126.com; guohu_di@163.com
FU National Key R&D Program of China [2018YFA0109800]; National Natural
   Science Foundation of China [81601754]
FX This work was supported by National Key R&D Program of China (grant no.
   2018YFA0109800) and National Natural Science Foundation of China (grant
   no. 81601754).
CR [Anonymous], 2014, OXID MED CELL LONGEV
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NR 29
TC 0
Z9 0
U1 0
U2 10
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1940-5901
J9 INT J CLIN EXP MED
JI Int. J. Clin. Exp. Med.
PY 2020
VL 13
IS 4
BP 2104
EP 2113
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA LJ3BE
UT WOS:000530042400002
DA 2026-05-27
ER

PT J
AU Rakhmatullaeva, MM
   Aminov, SN
AF Rakhmatullaeva, M. M.
   Aminov, S. N.
TI DEVELOPMENT OF COMPOSITION AND TECHNOLOGY FOR IMMUNSTIFIN CAPSULES
SO PHARMACEUTICAL CHEMISTRY JOURNAL
LA English
DT Article
DE immunstifin; salidroside; aerosil; capsules; calcium stearate; magnesium
   stearate; starch; dry extract
AB The physicochemical and technological properties of immunstifin parent substance (salidroside obtained from the dry extract of Rhodiola rosea) have been studied in order to select the composition and optimize the technology of the drug in capsules. The results showed the necessity of introducing excipients into the capsule composition. The best characteristics were obtained with the addition of starch, aerosil, and magnesium stearate in the following amounts: immunstifin substance, 0.1 g; potato starch, 0.098; aerosil, 0.0002; magnesium stearate, 0.0018. The average mass of a capsule is about 0.2000 g. This mixture was used to fill capsules soluble in the acidic media of gastric juice. Tests with immunstifin capsules in 0.1% solution met the pharmacopoeial quality requirements with respect to disintegration, dissolution, appearance, and all other indices.
C1 [Rakhmatullaeva, M. M.; Aminov, S. N.] Tashkent Pharmaceut Inst, Tashkent 700015, Uzbekistan.
C3 Tashkent Pharmaceutical Institute
RP Rakhmatullaeva, MM (corresponding author), Tashkent Pharmaceut Inst, Tashkent 700015, Uzbekistan.
OI Mavjuda, Rahmatullayeva/0000-0001-8074-5368
CR ALEKSEEVA VA, 1998, FARMATSIYA, P76
   ARIPOVA TU, 2007, TEORET MED TASHKENT, P6
   RAKHMATULLAEVA MM, 2007, THESIS TASHKENT
   RAKHMATULLAEVA MM, 2007, 2 INT SCI C CHEM TEC
   1990, STATE PHARMACOPOEIA, P143
NR 5
TC 0
Z9 0
U1 0
U2 6
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0091-150X
J9 PHARM CHEM J+
JI Pharm. Chem. J.
PD NOV
PY 2011
VL 45
IS 9
BP 575
EP 578
DI 10.1007/s11094-011-0682-z
PG 4
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 865SC
UT WOS:000298329600013
DA 2026-05-27
ER

PT J
AU Zhao, CC
   Wu, XY
   Yi, H
   Chen, R
   Fan, G
AF Zhao, Cheng-Cheng
   Wu, Xin-Yue
   Yi, Huan
   Chen, Rong
   Fan, Gang
TI The Therapeutic Effects and Mechanisms of Salidroside on Cardiovascular
   and Metabolic Diseases: An Updated Review
SO CHEMISTRY & BIODIVERSITY
LA English
DT Review
DE salidroside; metabolic disease; diabetes; cardiovascular disease;
   atherosclerosis
ID ISCHEMIA-REPERFUSION INJURY; TYPE-2 DIABETES-MELLITUS; FATTY
   LIVER-DISEASE; OLIVE OIL; LIPID-METABOLISM; MEDITERRANEAN DIET;
   RHODIOLA-CRENULATA; PHENOLIC-COMPOUNDS; ENDOTHELIAL-CELLS; OXIDATIVE
   STRESS
AB The increasing incidence of metabolic and cardiovascular diseases has severely affected global human health and life safety. In recent years, some effective drugs with remarkable curative effects and few side effects found in natural compounds have attracted attention. Salidroside (SAL), a phenylpropane glycoside, is the main active ingredient of the plateau plant Rhodiola. So far, many animal experiments proved that SAL has good biological activity against some metabolic and cardiovascular diseases. However, most of these reports are scattered. This review systematically summarizes the pharmacological progress of SAL in the treatment of several metabolic (e. g., diabetes and non-alcoholic fatty liver disease) and cardiovascular (e. g., atherosclerosis) diseases in a timely manner to promote the clinical application and basic research of SAL. Accumulating evidence proves that SAL has beneficial effects on these diseases. It can improve glucose tolerance, insulin sensitivity, and beta-cell and liver functions, and inhibit adipogenesis, inflammation and oxidative stress. Overall, SAL may be a valuable and potential drug candidate for the treatment of metabolic and cardiovascular diseases. However, more studies especially clinical trials are needed to further confirm its therapeutic effects and molecular mechanisms.
C1 [Zhao, Cheng-Cheng; Wu, Xin-Yue; Yi, Huan] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Peoples R China.
   [Chen, Rong; Fan, Gang] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu 611137, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Chen, R; Fan, G (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu 611137, Peoples R China.
EM chenrong@cdutcm.edu.cn; fangang1111@163.com
RI Fan, Gang/AGG-2500-2022
OI Fan, Gang/0000-0002-3023-9472
FU National Key Research and Development Program of China [2019YFC1712302];
   Xinglin Scholar Research Promotion Project of Chengdu University of TCM
   [XSGG2018013, QNXZ2018043]
FX The authors gratefully acknowledge the financial support from the
   National Key Research and Development Program of China (No.
   2019YFC1712302) and the Xinglin Scholar Research Promotion Project of
   Chengdu University of TCM (Nos. XSGG2018013 and QNXZ2018043).
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NR 104
TC 39
Z9 47
U1 4
U2 77
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1612-1872
EI 1612-1880
J9 CHEM BIODIVERS
JI Chem. Biodivers.
PD JUL
PY 2021
VL 18
IS 7
DI 10.1002/cbdv.202100033
EA JUN 2021
PG 12
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA TQ2AV
UT WOS:000658906100001
PM 33991395
DA 2026-05-27
ER

PT J
AU Xing, SS
   Li, J
   Chen, L
   Yang, YF
   He, PL
   Li, J
   Yang, J
AF Xing, Sha-Sha
   Li, Jian
   Chen, Lin
   Yang, Ya-Fei
   He, Ping-Lin
   Li, Jun
   Yang, Jin
TI Salidroside attenuates endothelial cellular senescence via decreasing
   the expression of inflammatory cytokines and increasing the expression
   of SIRT3
SO MECHANISMS OF AGEING AND DEVELOPMENT
LA English
DT Article
DE Salidroside; Inflammatory cytokines; SIRT3; Endothelial cellular
   senescence
ID OXIDATIVE STRESS; HOMOCYSTEINE; CELLS; HYPERHOMOCYSTEINEMIA; AORTA;
   DYSFUNCTION; MECHANISMS; PATHWAY; GROWTH; MICE
AB Objective: Endothelial cellular senescence is an important contributor to the endothelial dysfunction and atherosclerosis. Our previous studies suggested that salidroside (SAL) can alleviate atherosclerosis and protect endothelial cells against oxidative stress induced damage. However, the effect and mechanism of SAL on endothelial cellular senescence is still unclear. Here, we investigated the underlying mechanisms of SAL on preventing endothelial cellular premature senescence.
   Methods and results: We established a hyperhomocysteinemia (HHcy)mouse model via high methionine diet (HMD) to explore the protective effect of SAL. According to our results, the HMD elevated the concentration of serum homocysteine. HHcy induced the collagen deposition and the up-regulation of senescence markers, i.e. p16(INK4A) and p21(CIP1), in intima-medial of aorta. In addition, SAL also inhibited the expression of CD68 and intercellular adhesion molecule 1 (ICAM1) in aorta. In senescent human umbilical vein endothelial cells (HUVECs) induced by H2O2, SAL treatment alleviated the expression of p16(INK4A) and p21(CI)(P1) and reduced the activity of senescence-associated (SA)-beta-gal.
   Conclusion: our data suggested that SAL decreased the expression of inflammatory cytokines and up-regulated the expression of SIRT3, which might be the underlying mechanism of SAL on preventing endothelial cells from premature senescence.
C1 [Xing, Sha-Sha; Li, Jun; Yang, Jin] Chengdu Univ, Affiliated Hosp, Clin Drug Trial Ctr, Chengdu 610081, Sichuan, Peoples R China.
   [Li, Jian] Chengdu Univ, Sch Med, Dept Basic Med, Chengdu 610106, Sichuan, Peoples R China.
   [Chen, Lin; Yang, Ya-Fei; He, Ping-Lin; Yang, Jin] Chengdu Univ, Affiliated Hosp, Dept Urol, Chengdu 610081, Sichuan, Peoples R China.
   [Li, Jun] Chengdu Univ, Affiliated Hosp, Dept Gen Surg, Chengdu 610081, Sichuan, Peoples R China.
C3 Chengdu University; Chengdu University; Chengdu University; Chengdu
   University
RP Li, J; Yang, J (corresponding author), Chengdu Univ, Affiliated Hosp, Clin Drug Trial Ctr, Chengdu 610081, Sichuan, Peoples R China.
EM junl_paper@sina.com; dr.jinyang@163.com
RI xing, shasha/JFB-2393-2023; Li, Junshan/K-7564-2019
FU Technology Bureau of Chengdu [2015-HM01-00434-SF, 2015-HM01-00580-SF]
FX This work was supported by The Technology Bureau of Chengdu
   [2015-HM01-00434-SF, 2015-HM01-00580-SF].
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NR 34
TC 45
Z9 48
U1 1
U2 53
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0047-6374
J9 MECH AGEING DEV
JI Mech. Ageing Dev.
PD OCT
PY 2018
VL 175
BP 1
EP 6
DI 10.1016/j.mad.2017.12.005
PG 6
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA GU0IA
UT WOS:000444931800001
PM 29289557
DA 2026-05-27
ER

PT J
AU Shi, J
   Teng, YJ
   Li, D
   He, J
   Midgley, AC
   Guo, XQ
   Wang, XD
   Yang, XR
   Wang, SF
   Feng, YK
   Lv, Q
   Hou, SK
AF Shi, Jie
   Teng, Yanjiao
   Li, Duo
   He, Ju
   Midgley, Adam C.
   Guo, Xiaoqin
   Wang, Xiudan
   Yang, Xinran
   Wang, Shufang
   Feng, Yakai
   Lv, Qi
   Hou, Shike
TI Biomimetic tri-layered small-diameter vascular grafts with
   decellularized extracellular matrix promoting vascular regeneration and
   inhibiting thrombosis with the salidroside
SO MATERIALS TODAY BIO
LA English
DT Article
DE Small -diameter vascular graft; Biomimetic; Decellularized extracellular
   matrix; Antithrombosis; Tissue regeneration
ID CELL-ADHESION; IN-VIVO; ENDOTHELIALIZATION; SCAFFOLDS; DEPOSITION
AB Small-diameter vascular grafts (SDVGs) are urgently required for clinical applications. Constructing vascular grafts mimicking the defining features of native arteries is a promising strategy. Here, we constructed a tri-layered vascular graft with a native artery decellularized extracellular matrix (dECM) mimicking the component of arteries. The porcine thoracic aorta was decellularized and milled into dECM powders from the differential layers. The intima and media dECM powders were blended with poly (L-lactide-co-caprolactone) (PLCL) as the inner and middle layers of electrospun vascular grafts, respectively. Pure PLCL was electrospun as a strengthening sheath for the outer layer. Salidroside was loaded into the inner layer of vascular grafts to inhibit thrombus formation. In vitro studies demonstrated that dECM provided a bioactive milieu for human umbilical vein endothelial cell (HUVEC) extension adhesion, proliferation, migration, and tube-forming. The in vivo studies showed that the addition of dECM could promote endothelialization, smooth muscle regeneration, and extracellular matrix deposition. The salidroside could inhibit thrombosis. Our study mimicked the component of the native artery and combined it with the advantages of synthetic polymer and dECM which provided a promising strategy for the design and construction of SDVGs.
C1 [Shi, Jie; Teng, Yanjiao; Li, Duo; Guo, Xiaoqin; Wang, Xiudan; Yang, Xinran; Lv, Qi; Hou, Shike] Wenzhou Safety Emergency Inst Tianjin Univ, Wenzhou 325026, Peoples R China.
   [Shi, Jie; Teng, Yanjiao; Li, Duo; Guo, Xiaoqin; Wang, Xiudan; Yang, Xinran; Lv, Qi; Hou, Shike] Tianjin Univ, Inst Disaster & Emergency Med, Tianjin 300072, Peoples R China.
   [Shi, Jie; Teng, Yanjiao; Li, Duo; Guo, Xiaoqin; Wang, Xiudan; Yang, Xinran; Lv, Qi; Hou, Shike] Key Lab Disaster Med Technol, Tianjin 300072, Peoples R China.
   [He, Ju] Tianjin First Cent Hosp, Vasc Surg, Tianjin 300192, Peoples R China.
   [Midgley, Adam C.; Wang, Shufang] Nankai Univ, Coll Life Sci, Key Lab Bioact Mat, Minist Educ, Tianjin 300071, Peoples R China.
   [Feng, Yakai] Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China.
   [Feng, Yakai] Tianjin Univ, Frontiers Sci Ctr Synthet Biol, Tianjin 30072, Peoples R China.
   [Feng, Yakai] Tianjin Univ, Key Lab Syst Bioengn MOE, Tianjin 30072, Peoples R China.
C3 Tianjin University; Tianjin University; Tianjin Medical University;
   Nankai University; Tianjin University; Tianjin University; Tianjin
   University
RP Lv, Q; Hou, SK (corresponding author), Wenzhou Safety Emergency Inst Tianjin Univ, Wenzhou 325026, Peoples R China.
EM lvqi68@163.com; housk86@163.com
RI Teng, Yanjiao/MYQ-9941-2025; Midgley, Adam/P-8108-2019; Lv,
   Qi/KOZ-7439-2024; feng, yakai/F-3854-2015; Yang, Xinran/HNC-5812-2023;
   Guo, Xiaoqin/OHU-6833-2025
OI Teng, Yanjiao/0000-0002-2792-1219; Midgley, Adam/0000-0002-7622-0275;
   Li, Duo/0000-0001-8278-8011; 
FU Scienti fi c Research Translational Foundation of Wenzhou Safety
   (Emergency) Institute of Tianjin Univer-sity [TJUWYY2022008,
   TJUWYY2022020]; instrument analytical center of the School of
   Pharma-ceutical Science and Technology at Tianjin University; Scientific
   Research Translational Foundation of Wenzhou Safety (Emergency)
   Institute of Tianjin University [TJUWYY2022008, TJUWYY2022020]; Tianjin
   Natural Science Foundation [20JCYBJC01240]; National Natural Science
   Foundation of China [31870966]; Tianjin University Independent
   Innovation Fund of China [2021XZS-0025]
FX This work was supported by the Scientific Research Translational
   Foundation of Wenzhou Safety (Emergency) Institute of Tianjin University
   (TJUWYY2022008, TJUWYY2022020) , the Tianjin Natural Science Foundation
   (20JCYBJC01240) , the National Natural Science Foundation of China
   (31870966) , Tianjin University Independent Innovation Fund of China
   (2021XZS-0025) . Furthermore, the authors would like to acknowledge the
   instrument analytical center of the School of Pharmaceutical Science and
   Technology at Tianjin University.
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NR 55
TC 43
Z9 49
U1 10
U2 104
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2590-0064
J9 MATER TODAY BIO
JI Mater. Today Bio
PD AUG
PY 2023
VL 21
AR 100709
DI 10.1016/j.mtbio.2023.100709
EA JUL 2023
PG 13
WC Engineering, Biomedical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Materials Science
GA O1RM8
UT WOS:001041661700001
PM 37455822
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, X
   Kuang, G
   Wan, JY
   Jiang, R
   Ma, L
   Gong, X
   Liu, X
AF Zhang, Xue
   Kuang, Ge
   Wan, Jingyuan
   Jiang, Rong
   Ma, Li
   Gong, Xia
   Liu, Xing
TI Salidroside protects mice against CCl4-induced acute liver injury via
   down-regulating CYP2E1 expression and inhibiting NLRP3 inflammasome
   activation
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Acute liver injury; Salidroside; CYP2E1; NLRP3; Inflammatory response;
   Oxidative stress
ID OXIDATIVE STRESS; MECHANISM; APOPTOSIS; DISEASE; BURDEN; CANCER; ACID
AB Salidroside (Sal), a natural phenolic compound isolated from Rhodiola sachalinensis, has been utilized as anti-inflammatory and antioxidant for centuries, however, its effects against liver injury and the underlying mechanisms are unclear. This study was designed to evaluate the protective effects and underlying mechanisms of Sal on carbon tetrachloride (CCl4)-induced acute liver injury (ALI) in mice. C57BL/6 mice were pretreated with Sal before CCl4 injection, the serum and liver tissue were collected to evaluate liver damage and molecular indices. The results showed that Sal pretreatment dose-dependently attenuated CCl4-induced acute liver injury, as indicated by lowering the activities of serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT), and inhibiting hepatic pathological damage and apoptosis. In addition, Sal alleviated CCl4-primed oxidative stress and inflammatory response by restoring hepatic glutathione (GSH), superoxide dismutase (SOD), catalase (CAT), malondialdehyde (MDA), and inhibiting cytokines. Finally, Sal also down-regulated the expression of cytochrome P4502E1 (CYP2E1), and Nod-like receptor protein 3 (NLRP3) inflammasome activation in the liver of mice by CCl4. Our study demonstrates that Sal exerts its hepatoprotective effects on ALI through its antioxidant and anti-inflammatory effects, which might be mediated by down-regulating CYP2E1 expression and inhibiting NLRP3 inflammasome activation.
C1 [Zhang, Xue; Liu, Xing] Chongqing Med Univ, Childrens Hosp, Dept Orthoped,Chongqing Engn Res Ctr Stem Cell Th, Minist Educ,Key Lab Child Dev & Disorders,China I, Chongqing 400014, Peoples R China.
   [Zhang, Xue; Gong, Xia] Chongqing Med Univ, Dept Anat, Chongqing 400016, Peoples R China.
   [Kuang, Ge; Wan, Jingyuan; Ma, Li] Chongqing Med Univ, Dept Pharmacol, Chongqing 400016, Peoples R China.
   [Jiang, Rong] Chongqing Med Univ, Lab Stem Cell & Tissue Engn, Chongqing 400016, Peoples R China.
C3 Chongqing Medical University; Chongqing Medical University; Chongqing
   Medical University; Chongqing Medical University
RP Liu, X (corresponding author), Chongqing Med Univ, Childrens Hosp, Dept Orthoped,Chongqing Engn Res Ctr Stem Cell Th, Minist Educ,Key Lab Child Dev & Disorders,China I, Chongqing 400014, Peoples R China.; Gong, X (corresponding author), Chongqing Med Univ, Dept Anat, Chongqing 400016, Peoples R China.
EM xiagong@cqmu.edu.cn; liuxingda@126.com
RI ma, limei/B-6535-2008
FU science and technology innovation project of social undertakings and
   people's livelihood security of Chongqing Science and Technology
   Commission [cstc2016shmszx130079]
FX This research was funded by the science and technology innovation
   project of social undertakings and people's livelihood security of
   Chongqing Science and Technology Commission (No. cstc2016shmszx130079).
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NR 38
TC 75
Z9 82
U1 2
U2 35
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD AUG
PY 2020
VL 85
AR 106662
DI 10.1016/j.intimp.2020.106662
PG 8
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA MJ5QA
UT WOS:000548143500041
PM 32544869
DA 2026-05-27
ER

PT J
AU Chen, JJ
   Zhang, NF
   Mao, GX
   He, XB
   Zhan, YC
   Deng, HB
   Song, DQ
   Li, DD
   Li, ZR
   Si, SY
   Qiu, Q
   Wang, Z
AF Chen, Jin-Jing
   Zhang, Nian-Fei
   Mao, Gen-Xiang
   He, Xiao-Bo
   Zhan, Yue-Chen
   Deng, Hong-Bin
   Song, Dan-Qing
   Li, Dian-Dong
   Li, Zhuo-Rong
   Si, Shu-Yi
   Qiu, Qiang
   Wang, Zhen
TI Salidroside stimulates osteoblast differentiation through BMP signaling
   pathway
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Salidroside; Osteoblast differentiation; Bone Morphogenetic Proteins
   (BMP); Bone metabolism
ID BONE-FORMATION; IN-VITRO; OSTEOGENIC DIFFERENTIATION; MORPHOGENETIC
   PROTEINS; CELLS; EXPRESSION; INVOLVEMENT; ACTIVATION; C3H10T1/2; OSTERIX
AB Salidroside (SAL) is one of main active components of Rhodiola rosea L and possesses diverse pharmacological effects. However, the direct role of SAL in bone metabolism remains elusive. In this study, effects of SAL on osteoblast differentiation of murine pluripotent mesenchymal cell line C3H10T1/2 and osteoblastic cell line MC3T3-E1 were examined. We first identified SAL as a potential BMP2 activator in a cell-based screening assay. SAL (0.5-10 mu M) could slightly promote the proliferation and greatly increase the alkaline phosphatase (ALP) activity in both cells. Furthermore, SAL increased the mRNA expressions of osteoblast marker genes in either C3H10T1/2 or MC3T3-E1 cells after treatment for different time. Moreover, the mineralization of C3H10T1/2 cells assayed by Alizarin red S staining was dose-dependently increased by SAL Mechanistically, SAL increased the mRNA level of genes involved in the regulation of BMP signaling pathway, including BMP2, BMP6 and BMP7 and enhanced the phosphorylation of Smad1/5/8 and ERK1/2. The osteogenic effect of SAL was abolished by BMP antagonist noggin or by BMP receptor kinase inhibitor dorsomorphin. Further in vivo study demonstrated that SAL reversed bone loss in ovariectomized rats. Collectively, our findings indicate that SAL regulates bone metabolism through BMP signaling pathway. (C) 2013 Elsevier Ltd. All rights reserved.
C1 [Chen, Jin-Jing; Mao, Gen-Xiang; He, Xiao-Bo; Zhan, Yue-Chen; Deng, Hong-Bin; Song, Dan-Qing; Li, Dian-Dong; Li, Zhuo-Rong; Si, Shu-Yi; Wang, Zhen] Chinese Acad Med Sci, Inst Med Biotechnol, Beijing 100050, Peoples R China.
   [Chen, Jin-Jing; Mao, Gen-Xiang; He, Xiao-Bo; Zhan, Yue-Chen; Deng, Hong-Bin; Song, Dan-Qing; Li, Dian-Dong; Li, Zhuo-Rong; Si, Shu-Yi; Wang, Zhen] Peking Union Med Coll, Beijing 100050, Peoples R China.
   [Zhang, Nian-Fei] China Japan Friendship Hosp, Dept Orthoped, Beijing 100029, Peoples R China.
   [Mao, Gen-Xiang] Zhejiang Hosp, Geriatr Inst Zhejiang Prov, Hangzhou 310013, Zhejiang, Peoples R China.
   [Qiu, Qiang] Gen Hosp Peoples Liberat Army, Beijing 100853, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Institute of Medicinal Biotechnology - CAMS; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College;
   China-Japan Friendship Hospital
RP Qiu, Q (corresponding author), Gen Hosp Peoples Liberat Army, Beijing 100853, Peoples R China.
EM medsage@126.com; wangzhen@imb.pumc.edu.cn
RI Wang, Zhen/HKF-3829-2023
OI Wang, Zhen/0000-0002-6377-3890
FU National Science Foundation of China [81072645, 81328024]; National
   Mega-project for Innovative Drugs; Ministry of Science and Technology of
   China [2012ZX09301002-001-015, 2012ZX09301002-003]; PUMC Youth Project
FX This work is supported by grants from the National Science Foundation of
   China (81072645, 81328024), National Mega-project for Innovative Drugs
   by the Ministry of Science and Technology of China
   (2012ZX09301002-001-015; 2012ZX09301002-003) and PUMC Youth Project (to
   J Chen). We thank Prof. Patricia Ducy (The University of Texas M.D.
   Anderson Cancer Center, Houston, TX) for providing the plasmid of
   p6OSE2-luc, and thank Prof. Linfeng Chen (The University of Illinois at
   Urbana-Champaign, Urbana, IL) for helpful comments during the manuscript
   preparation.
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NR 43
TC 44
Z9 48
U1 0
U2 40
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD DEC
PY 2013
VL 62
BP 499
EP 505
DI 10.1016/j.fct.2013.09.019
PG 7
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA 293GW
UT WOS:000329960400066
PM 24055767
DA 2026-05-27
ER

PT J
AU Bernatoniene, J
   Jakstas, V
   Kopustinskiene, DM
AF Bernatoniene, Jurga
   Jakstas, Valdas
   Kopustinskiene, Dalia M.
TI Phenolic Compounds of Rhodiola rosea L. as the Potential
   Alternative Therapy in the Treatment of Chronic Diseases
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Review
DE Rhodiola rosea L; phenolic compounds; salidroside; chronic diseases;
   cancer
ID CANCER-CELLS; ALZHEIMERS-DISEASE; OXIDATIVE STRESS; SALIDROSIDE;
   EXTRACT; APOPTOSIS; GLYCOSIDES; CARDIOLIPIN; ANTIOXIDANT; MECHANISMS
AB The roots and rhizomes of Rhodiola rosea L. (Crassulaceae), which is widely growing in Northern Europe, North America, and Siberia, have been used since ancient times to alleviate stress, fatigue, and mental and physical disorders. Phenolic compounds: phenylpropanoids rosavin, rosarin, and rosin, tyrosol glucoside salidroside, and tyrosol, are responsible for the biological action of R. rosea, exerting antioxidant, immunomodulatory, anti-aging, anti-fatigue activities. R. rosea extract formulations are used as alternative remedies to enhance mental and cognitive functions and protect the central nervous system and heart during stress. Recent studies indicate that R. rosea may be used to treat diabetes, cancer, and a variety of cardiovascular and neurological disorders such as Alzheimer's and Parkinson's diseases. This paper reviews the beneficial effects of the extract of R. rosea, its key active components, and their possible use in the treatment of chronic diseases. R. rosea represents an excellent natural remedy to address situations involving decreased performance, such as fatigue and a sense of weakness, particularly in the context of chronic diseases. Given the significance of mitochondria in cellular energy metabolism and their vulnerability to reactive oxygen species, future research should prioritize investigating the potential effects of R. rosea main bioactive phenolic compounds on mitochondria, thus targeting cellular energy supply and countering oxidative stress-related effects.
C1 [Bernatoniene, Jurga; Jakstas, Valdas; Kopustinskiene, Dalia M.] Lithuanian Univ Hlth Sci, Inst Pharmaceut Technol, Med Acad, Fac Pharm, Sukileliu pr 13, LT-50161 Kaunas, Lithuania.
   [Bernatoniene, Jurga] Lithuanian Univ Hlth Sci, Med Acad, Fac Pharm, Dept Drug Technol & Social Pharm, Sukileliu pr 13, LT-50161 Kaunas, Lithuania.
   [Jakstas, Valdas] Lithuanian Univ Hlth Sci, Med Acad, Dept Pharmacognosy, Sukileliu pr 13, LT-50161 Kaunas, Lithuania.
C3 Lithuanian University of Health Sciences; Lithuanian University of
   Health Sciences; Lithuanian University of Health Sciences
RP Kopustinskiene, DM (corresponding author), Lithuanian Univ Hlth Sci, Inst Pharmaceut Technol, Med Acad, Fac Pharm, Sukileliu pr 13, LT-50161 Kaunas, Lithuania.
EM jurga.bernatoniene@lsmuni.lt; valdas.jakstas@lsmuni.lt;
   daliamarija.kopustinskiene@lsmuni.lt
RI Kopustinskiene, Dalia Marija/OGN-4626-2025; Bernatoniene,
   Jurga/JUV-0714-2023
OI Kopustinskiene, Dalia Marija/0000-0002-3399-2849; Jakštas,
   Valdas/0000-0001-7627-6263; Bernatoniene, Jurga/0000-0003-1744-2932
FU Pharmaceutical and Health Technology OpenAccess Center
FX The authors wish to thank the Pharmaceutical and Health Technology
   OpenAccess Center for support of this study.
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NR 140
TC 48
Z9 63
U1 9
U2 51
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD AUG
PY 2023
VL 24
IS 15
AR 12293
DI 10.3390/ijms241512293
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA O8NF8
UT WOS:001046317900001
PM 37569669
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Shi, SH
   Huang, DM
   Wu, YC
   Pei, CX
   Wang, YL
   Shen, ZR
   Zhao, SJ
   Jia, N
   Wang, XM
   Chen, BN
   Pan, J
   Wang, F
   Wang, ZX
AF Shi, Shihua
   Huang, Demei
   Wu, Yongcan
   Pei, Caixia
   Wang, Yilan
   Shen, Zherui
   Zhao, Sijing
   Jia, Nan
   Wang, Xiaomin
   Chen, Bonan
   Pan, Jie
   Wang, Fei
   Wang, Zhenxing
TI Salidroside pretreatment alleviates PM2.5 caused lung injury via
   inhibition of apoptosis and pyroptosis through regulating NLRP3
   Inflammasome
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Salidroside; PM2; 5 caused lung injury; Apoptosis; Pyroptosis; NLRP3
   inflammasome
ID CELL-DEATH; ACTIVATION; SALMONELLA; EXPOSURE; STRESS
AB Ambient fine particulate matter (PM2.5) is considered a leading cause of pathogenic particulate matter induced lung injury. And Salidroside (Sal), the major bioactive constituent isolated from Rhodiola rosea L., has been shown to ameliorate lung injury in various conditions. To uncover the possible therapy for PM2.5 related pulmonary dis-ease, we evaluated the protective role of Sal pre-treatment on PM2.5 induced lung injury in mice by utilizing the survival analysis, hematoxylin and eosin (H & E) staining, lung injury score, lung wet-to-dry weight ratio, enzyme -linked immunosorbent assay (ELISA) kits, immunoblot, immunofluorescence, and transmission electron micro-scopy (TEM). Impressively, our findings strongly indicated Sal as an effective precaution against PM2.5 induced lung injury. Pre-administration of Sal before PM2.5 treatment reduced the mortality within 120 h and alleviated inflammatory responses by reducing the release of proinflammatory cytokines, including TNF-& alpha;, IL-1 & beta;, and IL-18. Meanwhile, Sal pretreatment blocked apoptosis and pyroptosis that introduced the tissue damage under PM2.5 treatment via regulating Bax/Bcl-2/caspase-3 and NF-cB/NLRP3/caspase-1 signal pathways. In summary, our research demonstrated that Sal could be a potential preventative therapy for PM2.5 caused lung injury by inhibiting the initiation and development of apoptosis and pyroptosis through down-regulating NLRP3 inflam-masome pathway.
C1 [Shi, Shihua; Huang, Demei; Pei, Caixia; Wang, Yilan; Shen, Zherui; Zhao, Sijing; Jia, Nan; Wang, Xiaomin; Wang, Fei; Wang, Zhenxing] Hosp Chengdu Univ Tradit Chinese Med, Chengdu 610072, Peoples R China.
   [Shi, Shihua] Swiss Trop & Publ Hlth Inst, Dept Epidemiol & Publ Hlth, CH-4123 Basel, Switzerland.
   [Shi, Shihua] Univ Basel, Fac Sci, CH-4058 Basel, Switzerland.
   [Wu, Yongcan] Chongqing Key Lab Tradit Chinese Med Prevent & Cur, Chongqing 400016, Peoples R China.
   [Wu, Yongcan] Chongqing Med Univ, Coll Tradit Chinese Med, Chongqing 400016, Peoples R China.
   [Chen, Bonan] Chinese Univ Hong Kong, Prince Wales Hosp, Dept Anat & Cellular Pathol, State Key Lab Translat Oncol, Hong Kong 99907, Peoples R China.
   [Pan, Jie] Stanford Univ, Dept Pathol, Sch Med, Palo Alto, CA 94305 USA.
C3 Chengdu University of Traditional Chinese Medicine; University of Basel;
   Swiss Tropical & Public Health Institute; Swiss School of Public Health
   (SSPH+); University of Basel; Chongqing Medical University; Prince of
   Wales Hospital Hong Kong; Chinese University of Hong Kong; Stanford
   University
RP Wang, F; Wang, ZX (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, Chengdu 610072, Peoples R China.
EM wangfei@cdutcm.edu.cn; wangzhenxing@cdutcm.edu.cn
RI ; Shi, Shihua/AAT-7041-2021; Chen, Bonan/GQB-3701-2022; Zhao,
   Sijing/GSO-2862-2022
OI Pan, Jie/0000-0002-1973-8019; Shi, Shihua/0000-0001-6475-2349; Wang,
   Yilan/0000-0002-8230-4176; Chen, Bonan/0000-0002-2430-7934; Zhao,
   Sijing/0000-0002-4768-6527; Wu, Yongcan/0000-0002-0936-0737
FU China Postdoctoral Science Foundation [2020M683645XB]
FX This research was funded by the China Postdoctoral Science Foundation
   (No. 2020M683645XB). We greatly appreciate the pioneer of "WE" medicine,
   Prof. Yung-Chi Cheng of Yale School of Medicine. We thank him for the
   help and support for Shihua Shi's study.
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NR 62
TC 30
Z9 33
U1 3
U2 19
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD JUL
PY 2023
VL 177
AR 113858
DI 10.1016/j.fct.2023.113858
EA MAY 2023
PG 11
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA K0JK6
UT WOS:001013395600001
PM 37236293
DA 2026-05-27
ER

PT J
AU Su, YJ
   Zong, SH
   Wei, CM
   Song, FM
   Feng, HT
   Qin, A
   Lian, Z
   Fu, FS
   Shao, SY
   Fang, F
   Wu, TL
   Xu, JK
   Liu, Q
   Zhao, JM
AF Su, Yiji
   Zong, Shaohui
   Wei, Chengming
   Song, Fangming
   Feng, Haotian
   Qin, An
   Lian, Zhen
   Fu, Fangsheng
   Shao, Siyuan
   Fang, Fang
   Wu, Tailai
   Xu, Jiake
   Liu, Qian
   Zhao, Jinmin
TI Salidroside promotes rat spinal cord injury recovery by inhibiting
   inflammatory cytokine expression and NF-B and MAPK signaling pathways
SO JOURNAL OF CELLULAR PHYSIOLOGY
LA English
DT Article
DE astrocyte; inflammatory cytokines; lipopolysaccharide; salidroside;
   spinal cord injury
ID ISCHEMIA-REPERFUSION INJURY; KAPPA-B; FUNCTIONAL RECOVERY; ACTIVATION;
   APOPTOSIS; PRETREATMENT; PERMEABILITY; PROTECTION; AUTOPHAGY; STRESS
AB Spinal cord injury (SCI) is a public health problem in the world. The SCI usually triggers an excessive inflammatory response that brings about a secondary tissue wreck leading to further cellular and organ dysfunction. Hence, there is great potential of reducing inflammation for therapeutic strategies of SCI. In this study, we aim to investigate if Salidroside (SAD) exerts an anti-inflammatory effect and promotes recovery of motor function on SCI through suppressing nuclear factor-B (NF-B) and the mitogen-activated protein kinase (MAPK) pathways. In vitro, real-time polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA) were used to examine the inhibitory effect of SAD on the expression and release of interleukin-1 (IL-1), interleukin-6 (IL-6) and tumor necrosis factor- (TNF-) activated by lipopolysaccharide (LPS) in astrocytes. In addition, SAD was found to inhibit NF-B, p38 and extracellular-regulated protein kinases (ERK) signaling pathways by western blot analysis. Further, in vivo study showed that SAD was able to improve hind limb motor function and reduce tissue damage accompanied by the suppressed expression of inflammatory cytokines IL-1, IL-6, and TNF-. Overall, SAD could reduce the inflammatory response and promote motor function recovery in rats after SCI by inhibiting NF-B, p38, and ERK signaling pathways.
C1 [Su, Yiji; Wei, Chengming; Song, Fangming; Feng, Haotian; Qin, An; Fu, Fangsheng; Shao, Siyuan; Xu, Jiake; Liu, Qian; Zhao, Jinmin] Guangxi Med Univ, Affiliated Hosp 1, Guangxi Key Lab Regenerat Med, Res Ctr Regenerat Med, Nanning 530022, Guangxi, Peoples R China.
   [Zong, Shaohui] Guangxi Med Univ, Affiliated Hosp 1, Dept Spine Osteopathia, Nanning, Guangxi, Peoples R China.
   [Lian, Zhen] Shantou Univ, Med Coll, Affiliated Hosp 2, Dept Orthoped, Shantou, Guangdong, Peoples R China.
   [Fang, Fang] Eighth Peoples Hosp Nanning, Dept Neurol, Nanning, Guangxi, Peoples R China.
   [Wu, Tailai] Guangpo Town Cent Hosp, Gen Dept, Fangchenggang, Guangxi, Peoples R China.
   [Xu, Jiake; Liu, Qian] Univ Western Australia, Sch Biomed Sci, Perth, WA, Australia.
C3 Guangxi Medical University; Guangxi Medical University; Shantou
   University; University of Western Australia
RP Xu, JK; Liu, Q; Zhao, JM (corresponding author), Guangxi Med Univ, Affiliated Hosp 1, Guangxi Key Lab Regenerat Med, Res Ctr Regenerat Med, Nanning 530022, Guangxi, Peoples R China.
EM jiake.xu@uwa.edu.au; luoboqian@hotmail.com; zhaojinmin@126.com
RI Xu, Jiake/H-6129-2014; Zhao, Jinmin/LBH-0351-2024; Shao,
   Siyuan/JRY-4509-2023; Zhao, Jinmin/LBH-0351-2024
OI Xu, Jiake/0000-0003-2021-8309; Zhao, Jinmin/0000-0002-1047-8820; Zhao,
   Jinmin/0000-0001-8423-0425
FU 2016 "Talents Highland of Emergency and Medical Rescue of Guangxi
   Province in China" [GXJZ201610]; Guangxi key clinical specialist
   construction Programs of China; Research Project of Guangxi Health and
   Family Planning Commission [Z20170565]; National Natural Science
   Foundation of China [81501910]; Natural Science Foundation of Guangxi
   Province [2015GXNSFCA414001, 2015GXNSFDA139019]; Open Project of Guangxi
   Key Laboratory of Regenerative Medicine [Guizaizhongkai201705]
FX 2016 "Talents Highland of Emergency and Medical Rescue of Guangxi
   Province in China", Grant/Award Number: GXJZ201610; The Guangxi key
   clinical specialist construction Programs of China; The Research Project
   of Guangxi Health and Family Planning Commission, Grant/Award Number:
   Z20170565; National Natural Science Foundation of China, Grant/Award
   Number: 81501910; The Natural Science Foundation of Guangxi Province,
   Grant/Award Numbers: 2015GXNSFCA414001, 2015GXNSFDA139019; Open Project
   of Guangxi Key Laboratory of Regenerative Medicine, Grant/Award Number:
   Guizaizhongkai201705
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NR 47
TC 55
Z9 68
U1 3
U2 47
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0021-9541
EI 1097-4652
J9 J CELL PHYSIOL
JI J. Cell. Physiol.
PD AUG
PY 2019
VL 234
IS 8
BP 14259
EP 14269
DI 10.1002/jcp.28124
PG 11
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA HX2SA
UT WOS:000467240800188
PM 30656690
DA 2026-05-27
ER

PT J
AU Yuan, Y
   Wu, X
   Hong, YL
   Zhang, X
   Wang, ZY
   Yan, HY
AF Yuan, Yuan
   Wu, Xuan
   Hong, Yilin
   Zhang, Xu
   Wang, Ziyue
   Yan, Haiyang
TI Salidroside ameliorates liver metabonomics in relation to modified
   gut-liver FXR signaling in furan-induced mice
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Furan; Salidroside; Liver metabonomics; Gut barrier function; FXR
   signaling
ID BILE-SALT BIOTRANSFORMATIONS; NUCLEAR RECEPTOR; PROTECTIVE ROLE; ACID;
   INHIBITION; DAMAGE; METABOLOMICS; EXPRESSION; GROWTH; CELLS
AB The study aimed to investigate the ameliorative effect of salidroside (SAL) on the crosstalk among liver metabonomics, gut barrier function and bile acids in furan-induced mice. Forty male mice were randomly divided into the following five groups: CON, FUR 8 (8 mg/kg/day furan), SAL 10 (8 mg/kg/day furan+10 mg/kg/day SAL), SAL 20 (8 mg/kg/day furan+20 mg/kg/day SAL), and SAL 40 (8 mg/kg/day+40 mg/kg/day SAL). Mice were administered with furan for 30 days and SAL was administered for 15 days from day 16. Principal components analysis (PCA) and heatmap were employed to probe metabonomics profile alterations in liver tissues and select thirty-eight potential biomarkers. Pathway analysis revealed primary bile acids were largely changed in the biosynthesis pathway. Moreover, SAL regulated the activation of farnesoid X receptor (FXR), downregulating hepatic heterodimer partner (SHP), upregulating cholesterol 7a-hydroxylase (CYP7A1) as well as decreasing the expression of portal fibroblast growth factor 15 (FGF15), compared to the furan-treated group. Importantly, SAL dramatically increased the level of tight junction proteins, as immunohistochemistry results show. In conclusion, the ameliorative effects of SAL on liver damage induced by furan might be due to altered gut barrier function, while FXR signaling acted a significant role in the function of SAL.
C1 [Yuan, Yuan; Wu, Xuan; Hong, Yilin; Zhang, Xu; Wang, Ziyue; Yan, Haiyang] Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Peoples R China.
C3 Jilin University
RP Yan, HY (corresponding author), Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Peoples R China.
EM yanhyjlu@163.com
RI Zhang, Xu/NWH-4318-2025; wang, ziyue/IQT-0730-2023; yuan,
   Yuan/ISA-0923-2023
FU National Natural Science Foundation of China [31972181, 31571939]
FX This work was supported by funds from the National Natural Science
   Foundation of China (No. 31972181, 31571939). The authors gratefully
   acknowledge the funds supports.
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NR 48
TC 19
Z9 20
U1 0
U2 96
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD JUN
PY 2020
VL 140
AR 111311
DI 10.1016/j.fct.2020.111311
PG 10
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA LR7SA
UT WOS:000535895100023
PM 32251705
DA 2026-05-27
ER

PT J
AU Shi, TY
   Feng, SF
   Xing, JH
   Wu, YM
   Li, XQ
   Zhang, N
   Tian, Z
   Liu, SB
   Zhao, MG
AF Shi, Tian-yao
   Feng, Shu-fang
   Xing, Jiang-hao
   Wu, Yu-mei
   Li, Xiao-qiang
   Zhang, Nan
   Tian, Zhen
   Liu, Shui-bing
   Zhao, Ming-gao
TI Neuroprotective Effects of Salidroside and its Analogue Tyrosol
   Galactoside Against Focal Cerebral Ischemia In Vivo and
   H2O2-Induced Neurotoxicity In Vitro
SO NEUROTOXICITY RESEARCH
LA English
DT Article
DE Salidroside; Tyrosol galactoside; Apoptosis; Neuron; Middle cerebral
   artery occlusion
ID CULTURED HIPPOCAMPAL-NEURONS; OXIDATIVE STRESS; INDUCED APOPTOSIS;
   BRAIN; RATS; DISEASES; DAMAGE; ACTIVATION; MECHANISMS; GLUTAMATE
AB Salidroside (Sal) is a natural antioxidant extracted from the root of Rhodiola rosea L. that elicits neuroprotective effects in vivo and in vitro. Tyrosol galactoside (Tyr), an analog of Sal, was recently synthesized in our laboratory. The purpose of the current study was to investigate and compare the neuroprotective effects of Sal and Tyr against focal cerebral ischemia in vivo and H2O2-induced neurotoxicity in vitro. Sal and Tyr significantly prevented a cerebral ischemic injury induced by a 2 h middle cerebral artery occlusion and a 24 h reperfusion in rats in vivo. Furthermore, the oxidative insult was markedly attenuated by treatments of Sal and Tyr in the cultured rat cortical neurons after a 30 min exposure to 50 mu M of H2O2. Western blot analysis revealed that Sal and Tyr decreased the expression of Bax and restored the balance of pro- and anti-apoptotic proteins. The neuroprotective effects of these two analogues show that Tyr has a better antioxidative action compared with Sal both in vivo and in vitro, and suggest that the antioxidant activity of Sal and Tyr may be partly due to their different substituents in their glycosyl groups. This gives a new insight into the development of therapeutic natural antioxidants against oxidative stress.
C1 [Shi, Tian-yao; Xing, Jiang-hao; Wu, Yu-mei; Li, Xiao-qiang; Zhang, Nan; Tian, Zhen; Liu, Shui-bing; Zhao, Ming-gao] Fourth Mil Med Univ, Dept Pharmacol, Sch Pharm, Xian 710032, Peoples R China.
   [Feng, Shu-fang] Fourth Mil Med Univ, Dept Psychosomat, Xijing Hosp, Xian 710032, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Liu, SB (corresponding author), Fourth Mil Med Univ, Dept Pharmacol, Sch Pharm, Xian 710032, Peoples R China.
EM liushb1974@yahoo.com.cn; minggao@fmmu.edu.cn
RI Liu, Shuibing/NWH-3287-2025; Li, Xiao-Qiang/AAA-5094-2019; xing,
   jianghao/MGT-8314-2025; Wu, Yu-Mei/JXL-3940-2024
OI Li, Xiao-Qiang/0000-0003-2463-8298; Zhao, Ming-gao/0000-0002-7539-3887;
   Feng, Shufang/0000-0002-1681-7096; Wu, Yu-Mei/0000-0002-8524-1254
FU National Natural Science Foundation of China [31070923, 2008
   ZXJ09004-023, 2009ZX09103-111]; Program for New Century Excellent
   Talents in University
FX This study was supported by the National Natural Science Foundation of
   China No. 31070923, 2008 ZXJ09004-023, 2009ZX09103-111, and Program for
   New Century Excellent Talents in University.
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NR 44
TC 97
Z9 107
U1 0
U2 43
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1029-8428
EI 1476-3524
J9 NEUROTOX RES
JI Neurotox. Res.
PD MAY
PY 2012
VL 21
IS 4
BP 358
EP 367
DI 10.1007/s12640-011-9290-7
PG 10
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 909UE
UT WOS:000301589900002
PM 22095090
DA 2026-05-27
ER

PT J
AU Zhu, ZS
   Li, LY
   Zhang, XR
AF Zhu, Zhongsheng
   Li, Linyu
   Zhang, Xiaorong
TI Salidroside protects against ox-LDL-induced endothelial injury by
   enhancing autophagy mediated by SIRT1-FoxO1 pathway
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Atherosclerosis; Salidroside (SAL); Oxidized low-density lipoprotein
   (ox-LDL); Endothelial cell; Oxidative stress; Autophagy
ID OXIDATIVE STRESS; APOPTOSIS; FOXO1; ATHEROSCLEROSIS; SENESCENCE; CELLS;
   SIRT1
AB Background: Atherosclerosis is a condition with the vascular accumulation of lipid plaques, and its main major contributing factor is endothelial injury induced by oxidized low-density lipoprotein (ox-LDL). Salidroside (SAL) is the primary active ingredient of Rhodiola rosea, and exhibits antioxidant properties on endothelial cells and alleviates atherosclerosis. However, the effect of SAL on autophagy in ox-LDL-induced vascular endothelial injury remains unclear. Here, we investigated the effect and underlying mechanisms of SAL on autophagy in human umbilical vein endothelial cells (HUVECs).
   Methods: HUVECs were incubated with ox-LDL to induce in vitro atherosclerosis model. The cell viability and injury were evaluated by cell counting kit-8 (CCK-8) assay and lactate dehydrogenase (LDH) release assay. The oxidative stress was evaluated by NADPH oxidase, malondialdehyde (MDA) and superoxide dismutase (SOD) activities. Immunofluorescence was performed to detect autophagy using LC3 beta antibody. Quantitative real-time PCR (qRT-PCR) and western blot were performed to measure the mRNA expressions of SIRT1 and Forkhead box O1 (FOXO1). Nicotinamide (NAM) and AS1842856 were used to inhibit activities of SIRT1 and FOXO1, respectively.
   Results: Exposure of HUVECs to ox-LDL (100 mu g/mL) reduced cell viability, increased cellular MDA, and reduced SOD in a concentration-dependent manner. The pretreatment with SAL (20, 50 and 100 mu M) significantly enhanced the cell viability and decreased LDH release in HUVECs exposed to ox-LDL (100 mu g/mL). ox-LDL induced autophagy in HUVECs, which was further enhanced by pretreatment with SAL. However, SAL attenuated increase in oxidative stress in HUVECs induced by ox-LDL. ox-LDL reduced mRNA and protein expressions of SIRT1 and FOXO1, which could be reversed by SAL. The protective, anti-oxidative and pro-autophagic effects of SAL could be obviously abolished by cotreatment with SIRT1 inhibitor or FOXO1 inhibitor.
   Conclusion: Salidroside shows protective effect on endothelial cell induced by ox-LDL, and the mechanisms might be related to autophagy induction via increasing SIRT1 and FoxO1 expressions.
C1 [Zhu, Zhongsheng; Li, Linyu; Zhang, Xiaorong] Fudan Univ, Shanghai Pudong Hosp, Dept Cardiol, Pudong Med Ctr, 2800 Gongwei Rd, Shanghai 201399, Peoples R China.
C3 Fudan University
RP Zhu, ZS (corresponding author), Fudan Univ, Shanghai Pudong Hosp, Dept Cardiol, Pudong Med Ctr, 2800 Gongwei Rd, Shanghai 201399, Peoples R China.
EM zhuzssh@163.com
FU Key Specialty Construction Project of Pudong New District of Shanghai
   [PWZzk2017-17]
FX This study was supported by Key Specialty Construction Project of Pudong
   New District of Shanghai (Grant No: PWZzk2017-17). The funder provided
   financial support for our experiment.
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NR 30
TC 76
Z9 89
U1 1
U2 23
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD MAY 30
PY 2019
VL 19
AR 111
DI 10.1186/s12906-019-2526-4
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA IA7WS
UT WOS:000469769600001
PM 31146723
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xia, Y
   Tian, ZY
   Guo, YL
   Qian, XL
   Jiang, HS
   Tao, D
   Xie, C
AF Xia, Ya
   Tian, Zhiyuan
   Guo, Yalan
   Qian, Xiaoling
   Jiang, Hongshuang
   Tao, Dan
   Xie, Chun
TI Salidroside Alleviates Fluoride-Induced Pyroptosis and Developmental
   Neurotoxicity Through P2X7R/NF-κB/NLRP3 Pathway
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Fluoride; Striatum; Pyroptosis; Developmental neurotoxicity; Salidroside
ID NF-KAPPA-B; NLRP3; ACTIVATION
AB Fluoride can cause damage to neurons, but the specific mechanisms remain unclear. Neuronal pyroptosis is associated with cognitive dysfunction, but previous studies mainly focused on hippocampal impairments. This study aimed to whether the P2X7R/NF-kappa B/NLRP3 pathway would trigger pyroptosis in striatal neurons, thereby mediating neurotoxicity of fluoride, and to evaluate the therapeutic potential of salidroside (Sal). Sal, a key bioactive compound derived from Rhodiola rosea, has been reported that it mainly reduces cell pyroptosis by inhibiting the P2X7R/NF-kappa B/NLRP3 regulatory axis, thereby improving the neurological function in the brain injury models. Therefore, this study explored, this study investigated its potential protective effects against fluoride-induced neurotoxicity. Therefore, an in vivo model of the second-generation (F2) SD rats and an in vitro model of NG108-15 cells exposed to fluoride with Sal intervention were established. The radial arm maze (RAM) was used to measure neurobehavioral changes. Hematoxylin-Eosin (HE) and transmission electron microscopy (TEM) were used to observe histopathological and ultrastructural changes in the striatum of F2 rats. Cell viability and the expressions of pyroptosis-related proteins were measured using biochemical methods. HE staining demonstrated striatal neuronal degeneration in fluoride-exposed groups, the RAM test indicated neurobehavioral defects, and TEM identified ultrastructural neuronal damage. Fluoride activated the P2X7R/NF-kappa B/NLRP3 pathway, promoting pyroptosis and impairing the memory ability in F2 rats. Mechanistically, Sal mitigated fluoride-induced neuronal loss by blocking P2X7R/NF-kappa B/NLRP3 signaling and pyroptotic cell death. In summary, these findings suggest the P2X7R/NF-kappa B/NLRP3 axis mediates fluoride-induced striatal pyroptosis and neurotoxicity, positioning salidroside as a promising therapeutic candidate.Graphical AbstractA proposed model for the role of pyroptosis in fluoride neurotoxicity and neuroprotective effect of Sal. P2X7R/NF-kappa B/NLRP3 pathway conducted pyroptosis plays a vital role in fluoride neurotoxicity. Specifically, inhibiting P2X7R/NF-kappa B/NLRP3 pathway by the Sal alleviated fluoride-induced pyroptosis, prevented the resultant apoptosis, and promoted neuronal survival
C1 [Xia, Ya; Tian, Zhiyuan; Guo, Yalan; Qian, Xiaoling; Jiang, Hongshuang; Tao, Dan; Xie, Chun] Guizhou Med Univ, Minist Educ, Sch Publ Hlth, Key Lab Environm Pollut Monitoring & Dis Control, Guiyang 561113, Peoples R China.
   [Tian, Zhiyuan; Tao, Dan; Xie, Chun] Guizhou Med Univ, Collaborat Innovat Ctr Prevent & Control Endem & E, Guiyang 561113, Peoples R China.
C3 Guizhou Medical University; Guizhou Medical University
RP Xie, C (corresponding author), Guizhou Med Univ, Minist Educ, Sch Publ Hlth, Key Lab Environm Pollut Monitoring & Dis Control, Guiyang 561113, Peoples R China.; Xie, C (corresponding author), Guizhou Med Univ, Collaborat Innovat Ctr Prevent & Control Endem & E, Guiyang 561113, Peoples R China.
EM 1009207189@qq.com
FU National Key R&D Program of China [2022YFC2503002]; Guizhou Provincial
   Basic Research Program (Natural Science) [No. ZK[2024] 122]
FX Funding for this project was provided by the National Key R&D Program of
   China (2022YFC2503002) and Guizhou Provincial Basic Research Program
   (Natural Science) (No. ZK[2024] 122).
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NR 59
TC 0
Z9 0
U1 1
U2 1
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD APR
PY 2026
VL 204
IS 4
BP 2726
EP 2740
DI 10.1007/s12011-025-04852-2
EA NOV 2025
PG 15
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA HI0NB
UT WOS:001619072700001
PM 41264175
DA 2026-05-27
ER

PT J
AU Wang, HW
   Wu, T
   Qi, JY
   Wang, YQ
   Luo, XP
   Ning, Q
AF Wang, Hong-wu
   Wu, Ting
   Qi, Jun-ying
   Wang, Ya-qi
   Luo, Xiao-ping
   Ning, Qin
TI Salidroside Attenuates LPS-stimulated Activation of THP-1 Cell-derived
   Macrophages through Down-regulation of MAPK/NF-kB Signaling Pathways
SO JOURNAL OF HUAZHONG UNIVERSITY OF SCIENCE AND TECHNOLOGY-MEDICAL
   SCIENCES
LA English
DT Article
DE salidroside; THP-1; MAPK; LPS; NF-kappa B
ID FACTOR-KAPPA-B; NITRIC-OXIDE SYNTHASE; TNF-ALPHA; MOUSE MACROPHAGES;
   COX-2 EXPRESSION; LIPOPOLYSACCHARIDE; INFLAMMATION; INHIBITION;
   RECEPTORS; INDUCTION
AB Excessive activation of macrophages is implicated in various inflammatory injuries. Salidroside (Sal), one of the main bioactive components of Rhodiola Sachalinensis, has been reported to possess anti-inflammatory activities. This study aimed to examine the effect of Sal on the activation of macrophages and the possible mechanism. The lipopolysaccharide (LPS)-stimulated phrobol 12-myristate 13-acetate (PMA)-differentiated THP-1 macrophage models were established. The changes in the inflammatory profiles of THP-1-derived macrophages were determined. The results showed that Sal significantly decreased the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX2), interleukin-1beta (IL-1 beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) at both mRNA and protein levels in THP-1-derived macrophages, and the effect was dose-depedent. Moreover, NF-kappa B activation was significantly suppressed and the phosphorylation of ERK, p38 and JNK was substantially down-regulated after Sal treatment. The findings suggested that Sal can suppress the activation of LPS-stimulated PMA-differetiated THP-1 cells, as evidenced by the decreased expression of iNOS, COX2, IL-1 beta, IL-6 and TNF-alpha, and the mechanism involves the inhibition of NF-kappa B activation and the phosphorylation of the MAPK signal pathway.
C1 [Wang, Hong-wu; Wu, Ting; Qi, Jun-ying; Wang, Ya-qi; Ning, Qin] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Infect Dis, Wuhan 430030, Peoples R China.
   [Luo, Xiao-ping] Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Pediat, Wuhan 430030, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Ning, Q (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Tongji Hosp, Dept Infect Dis, Wuhan 430030, Peoples R China.
EM hongwuwang@126.com; qning@vip.sina.com
FU National Natural Science Foundation of China [81100282, 81030007,
   81171558, 81271808]; Program for Changjiang Scholars and Innovative
   Research Team in University [PCSIRT1131]; China Postdoctoral Science
   Foundation [2013M531700]
FX This project was supported by grants from the National Natural Science
   Foundation of China (Nos. 81100282, 81030007, 81171558, 81271808),
   Program for Changjiang Scholars and Innovative Research Team in
   University (No. PCSIRT1131), and China Postdoctoral Science Foundation
   (No. 2013M531700).
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NR 43
TC 29
Z9 30
U1 0
U2 38
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 1672-0733
EI 1993-1352
J9 J HUAZHONG U SCI-MED
JI J. Huazhong Univ. Sci. Tech.-Med.
PD AUG
PY 2013
VL 33
IS 4
BP 463
EP 469
DI 10.1007/s11596-013-1143-6
PG 7
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 211LC
UT WOS:000323907700002
PM 23904362
DA 2026-05-27
ER

PT J
AU Wang, Y
   Xu, CF
   Liu, YJ
   Mao, YF
   Lv, Z
   Li, SY
   Zhu, XY
   Jiang, L
AF Wang, Yan
   Xu, Chu-Fan
   Liu, Yu-Jian
   Mao, Yan-Fei
   Lv, Zhou
   Li, Si-Yuan
   Zhu, Xiao-Yan
   Jiang, Lai
TI Salidroside Attenuates Ventilation Induced Lung Injury via
   SIRT1-Dependent Inhibition of NLRP3 Inflammasome
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article
DE Salidroside; Ventilation; induced lung injury; NLRP3 inflammasome;
   SIRT1; Cyclic stretch
ID INDUCED CARDIOTOXICITY; OXIDATIVE STRESS; ACTIVATION; SIRT1;
   RESVERATROL; APOPTOSIS; PROTECTS; CELLS; PATHWAY; ALPHA
AB Background: Salidroside (SDS) is the main effective ingredient of Rhodiola rosea L with a variety of pharmacologic properties. We aim to investigate the effects of SDS on ventilation induced lung injury (VILI) and explore the possible underlying molecular mechanism. Methods: Lung injury was induced in male ICR mice via mechanical ventilation (30 ml/ kg) for 4h. The mice were divided in four groups:(1) Control group; (2) Ventilation group; (3) SDS group; (4) Ventilation with SDS group. SDS (50 mg/ kg) was injected intraperitoneally 1h before operation. Mouse lung vascular endothelial cells (MLVECs) were subjected to cyclic stretch for 4h. Results: It was found that SDS attenuated VILI as shown in HE staining, cell count and protein content levels in BAL fluid, W/ D and Evans blue dye leakage into the lung tissue. SDS treatment inhibited the activation of NLRP3 inflammasome and subsequent caspase- 1 cleavage as well as interleukin (IL)- 1 beta secretion both in vivo and in vitro. Moreover, SDS administration up- regulated SIRT1 expression. Importantly, knockdown of SIRT1 reversed the inhibitory effect of SDS on NLRP3 inflammasome activation. Conclusions: Taken together, these findings indicate that SDS may confer protection against ventilation induced lung injury via SIRT1- dependent inhibition of NLRP3 inflammasome activation. (C)2017 The Author(s) Published by S. Karger AG, Basel
C1 [Wang, Yan; Xu, Chu-Fan; Mao, Yan-Fei; Lv, Zhou; Li, Si-Yuan; Jiang, Lai] Shanghai Jiao Tong Univ, Sch Med, Dept Anesthesiol, Xinhua Hosp, Shanghai 200092, Peoples R China.
   [Wang, Yan; Xu, Chu-Fan; Mao, Yan-Fei; Lv, Zhou; Li, Si-Yuan; Jiang, Lai] Shanghai Jiao Tong Univ, Sch Med, Surg Intens Care Unit, Xinhua Hosp, Shanghai 200092, Peoples R China.
   [Zhu, Xiao-Yan] Second Mil Med Univ, Minist Educ, Dept Physiol, Shanghai, Peoples R China.
   [Zhu, Xiao-Yan] Second Mil Med Univ, Minist Educ, Key Lab Mol Neurobiol, Shanghai, Peoples R China.
   [Wang, Yan; Xu, Chu-Fan; Liu, Yu-Jian] Shanghai Univ Sport, Key Lab Exercise & Hlth Sci, Minist Educ, Sch Kinesiol, Shanghai, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University; Naval
   Medical University; Naval Medical University; Shanghai University of
   Sport
RP Jiang, L (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Dept Anesthesiol, Xinhua Hosp, Shanghai 200092, Peoples R China.; Jiang, L (corresponding author), Shanghai Jiao Tong Univ, Sch Med, Surg Intens Care Unit, Xinhua Hosp, Shanghai 200092, Peoples R China.; Zhu, XY (corresponding author), Second Mil Med Univ, Dept Physiol, 800 Xiangyin Rd, Shanghai 200433, Peoples R China.
EM xiaoyanzhu@smmu.edu.cn; jianglaimz@126.com
RI Li, Siyuan/JQW-0126-2023; zhu, xiaoyan/AAQ-6601-2021
FU National Natural Science Foundation of China [81571929, 81272144,
   31671213, 31271270, 81372100, 81672266, 31371164]
FX The authors of this article have no conflict of interest. This work was
   supported by grants from the National Natural Science Foundation of
   China to Dr. Jiang (No. 81571929, No. 81272144), Dr. Zhu (No. 31671213,
   No. 31271270), Dr. Mao (No. 81372100) and Dr. Liu (No. 81672266, No.
   31371164).
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NR 34
TC 49
Z9 54
U1 1
U2 44
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2017
VL 42
IS 1
BP 34
EP 43
DI 10.1159/000477112
PG 10
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA FA8YZ
UT WOS:000405734000004
PM 28490015
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, JS
   Fan, LY
   Yuan, MD
   Xing, MY
AF Li, Jian-sha
   Fan, Lu-yao
   Yuan, Meng-dan
   Xing, Ming-you
TI Salidroside Inhibits Lipopolysaccharide-ethanol-induced Activation of
   Proinflammatory Macrophages via Notch Signaling Pathway
SO CURRENT MEDICAL SCIENCE
LA English
DT Article
DE THP-1 macrophages; Salidroside; Notch; tumor necrosis factor-alpha;
   monocyte chemoattractant protein-1
ID NF-KAPPA-B; INFLAMMATORY RESPONSES; DEACTIVATION; ALCOHOL
AB Activation of macrophages is a key event for the pathogenesis of various inflammatory diseases. Notch signaling pathway recently has been found to be a critical pathway in the activation of proinflammatory macrophages. Salidroside (Sal), one of main bioactive components in Rhodiola crenulata (Hook. F. et Thoms) H. ohba, reportedly possesses anti-inflammatory activity and ameliorates inflammation in alcohol-induced hepatic injury. However, whether Sal regulates the activation of proinflammatory macrophages through Notch signaling pathway remains unknown. The present study investigated the effects of Sal on macrophage activation and its possible mechanisms by using both alcohol and lipopolysaccharide (LPS) to mimic the microenvironment of alcoholic liver. Detection of THP-1-derived macrophages exhibited that Sal could significantly decrease the expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta) and IL-6 in the macrophages at both mRNA and protein levels. Furthermore, Sal significantly suppressed NF-kappa B activation via Notch-Hes signaling pathway in a dose-dependent manner. Moreover, in the microenvironment of alcoholic liver, the expression of Notch-dependent pyruvate dehydrogenase phosphatase 1 (PDP1) was elevated, and that of M1 gene expression [inducible NO synthase (NOS2)] was up-regulated. These changes could all be effectively ameliorated by Sal. The aforementioned findings demonstrated that Sal could inhibit LPS-ethanol-induced activation of proinflammatory macrophages via Notch signaling pathway.
C1 [Li, Jian-sha; Fan, Lu-yao; Yuan, Meng-dan] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Inst Pathol, Wuhan 430030, Hubei, Peoples R China.
   [Li, Jian-sha; Fan, Lu-yao; Yuan, Meng-dan] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med Sci, Dept Pathol, Wuhan 430030, Hubei, Peoples R China.
   [Xing, Ming-you] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Infect Dis, Wuhan 430030, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology; Huazhong University of Science & Technology
RP Xing, MY (corresponding author), Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Infect Dis, Wuhan 430030, Hubei, Peoples R China.
EM lijiansha@163.com; xingmingyou@126.com
FU National Natural Science Foundation of China [81572274]
FX This study was supported by the National Natural Science Foundation of
   China (No. 81572274).
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Z9 28
U1 1
U2 32
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 2096-5230
EI 2523-899X
J9 CURR MED SCI
JI Curr. Med. Sci.
PD AUG
PY 2019
VL 39
IS 4
BP 526
EP 533
DI 10.1007/s11596-019-2069-4
PG 8
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA IL8ZV
UT WOS:000477575900003
PM 31346986
DA 2026-05-27
ER

PT J
AU Jiang, B
   Feng, LF
   Yang, T
   Guo, WJ
   Li, YY
   Wang, T
   Liu, CG
   Su, HX
AF Jiang, Bing
   Feng, Longfei
   Yang, Tao
   Guo, Wenjing
   Li, Yangyang
   Wang, Tao
   Liu, Chengguang
   Su, Haixiang
TI Combination of chloroquine diphosphate and salidroside induces human
   liver cell apoptosis via regulation of mitochondrial dysfunction and
   autophagy
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE salidroside; chloroquine diphosphate; liver cancer; apoptosis;
   autophagy; PI3K; Akt; mTOR
ID HEPATOCELLULAR-CARCINOMA CURRENT; CANCER; CASPASE; PI3K/AKT/MTOR;
   INHIBITION; ACTIVATION; INTERPLAY; PATHWAY; GROWTH; DEATH
AB Hepatocellular carcinoma (HCC) is the leading cause of cancer-associated death in the world. Chemotherapy remains the primary treatment method for HCC. Despite advances in chemotherapy and modalities, recurrence and resistance limit therapeutic success. Salidroside (Sal), a bioactive component extracted from the rhizome of Rhodiola rosea L, exhibits a spectrum of biological activities including antitumor effects. In the present study, it was demonstrated that Sal could induce apoptosis and autophagy of 97H cells by using CCK-8 assay, transmission electron microscopy (TEM), Hoechst33342 staining, MDC staining, western blotting. Pretreatment with Sal enhanced apoptosis and autophagy via upregulation of expression levels of Bax, Caspase-3, Caspase-9, light chain (LC)3-II and Beclin-1 proteins and downregulation of expression levels of Bcl-2, LC3-I and p62 protein in 97H cells. Furthermore, Sal was demonstrated to inhibit activation of the PI3K/Akt/mTOR signaling pathway and, when combined with autophagy inhibitor chloroquine diphosphate (CQ), increased phosphorylation of PI3K, Akt and mTOR proteins. The combined treatment with Sal and CQ not only decreased Sal-induced autophagy, but also accelerated Sal-induced apoptosis. Therefore, Sal-induced autophagy might serve a role as a defense mechanism in human liver cancer cells and its inhibition may be a promising strategy for the adjuvant chemotherapy of liver cancer.
C1 [Jiang, Bing; Feng, Longfei; Yang, Tao; Guo, Wenjing; Li, Yangyang; Su, Haixiang] Gansu Univ Tradit Chinese Med, Sch Basic Med, Lanzhou 730000, Gansu, Peoples R China.
   [Wang, Tao; Su, Haixiang] Gansu Prov Canc Hosp, Gansu Prov Acad Inst Med Res, Translat Med Res Ctr, Lanzhou 730050, Gansu, Peoples R China.
   [Liu, Chengguang] Guangxi Univ Tradit Chinese Med, Clin Coll Integrated Chinese & Western Med, Nanning 530200, Guangxi, Peoples R China.
   [Su, Haixiang] Gansu Prov Canc Hosp, Gansu Prov Acad Inst Med Res, Translat Med Res Ctr, 2 Xiaoxihu East St, Lanzhou 730050, Gansu, Peoples R China.
C3 Gansu University of Chinese Medicine; Gansu Provincial Cancer Hospital
   (Gansu Provincial Academic Institute for Medical Research); Guangxi
   University of Chinese Medicine; Gansu Provincial Cancer Hospital (Gansu
   Provincial Academic Institute for Medical Research)
RP Su, HX (corresponding author), Gansu Prov Canc Hosp, Gansu Prov Acad Inst Med Res, Translat Med Res Ctr, 2 Xiaoxihu East St, Lanzhou 730050, Gansu, Peoples R China.
EM shxsuhaixiang54120@163.com
RI SU, HAIXIANG/B-7347-2018
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U2 30
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD FEB
PY 2023
VL 27
IS 2
AR 37
DI 10.3892/mmr.2022.12924
PG 12
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA 7Q6ZS
UT WOS:000909537900001
PM 36579660
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Feng, J
   Niu, PQ
   Chen, K
   Wu, LW
   Liu, T
   Xu, SZ
   Li, JJ
   Li, SN
   Wang, WW
   Lu, XY
   Yu, Q
   Liu, N
   Xu, L
   Wang, F
   Dai, WQ
   Xia, YJ
   Fan, XM
   Guo, CY
AF Feng, Jiao
   Niu, Peiqin
   Chen, Kan
   Wu, Liwei
   Liu, Tong
   Xu, Shizan
   Li, Jingjing
   Li, Sainan
   Wang, Wenwen
   Lu, Xiya
   Yu, Qiang
   Liu, Ning
   Xu, Ling
   Wang, Fan
   Dai, Weiqi
   Xia, Yujing
   Fan, Xiaoming
   Guo, Chuanyong
TI Salidroside mediates apoptosis and autophagy inhibition in concanavalin
   A-induced liver injury
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE salidroside; concanavalin A; liver injury; apoptosis; autophagy;
   phosphoinositide 3-kinase/Akt; LY294002
ID ISCHEMIA-REPERFUSION INJURY; TUMOR-NECROSIS-FACTOR; AUTOIMMUNE
   HEPATITIS; PI3K/AKT PATHWAY; RHODIOLA-ROSEA; BREAST-CANCER; CELL-DEATH;
   MICE; ACTIVATION; PHOSPHORYLATION
AB Salidroside (Sal) is a glycoside extract from Rhodiola rosea L. with anti-inflammatory, antioxidant, anticancer and cardioprotective properties. The present study explored the protective effects and the possible mechanisms of Sal on concanavalin A (ConA)-induced liver injury in mice. Balb/C mice were divided into five groups: Normal control (injected with normal saline), ConA (25 mg/kg), Sal (10 mg/kg) + ConA, Sal (20 mg/kg) + ConA (Sal injected 2 h prior to ConA injection) and Sal (20 mg/kg) only. The serum levels of liver enzymes, pro-inflammatory cytokines, and apoptosis-and autophagy-associated marker proteins were determined at 2, 8 and 24 h after ConA injection. LY294002 was further used to verify whether the phosphoinositide 3-kinase (PI3K)/Akt pathway was activated. Primary hepatocytes were isolated to verify the effect of Sal in vitro. The results indicated that Sal was a safe agent to reduce pathological damage and serum liver enzymes in ConA-induced liver injury. Sal suppressed inflammatory reactions in serum and liver tissues, and activated the PI3K/Akt signaling pathway to inhibit apoptosis and autophagy in vivo and in vitro, which could be reversed by LY294002. In conclusion, Sal attenuated ConA-induced liver injury by modulating PI3K/Akt pathway-mediated apoptosis and autophagy in mice.
C1 [Feng, Jiao; Chen, Kan; Wu, Liwei; Liu, Tong; Li, Jingjing; Li, Sainan; Wang, Wenwen; Lu, Xiya; Xia, Yujing; Guo, Chuanyong] Tongji Univ, Shanghai Peoples Hosp Affiliated 10, Sch Med, Dept Gastroenterol, 301 Middle Yanchang Rd, Shanghai 200072, Peoples R China.
   [Niu, Peiqin] Tongji Univ, Shanghai Peoples Hosp 10, Sch Med, Dept Gastroenterol,Chongming Branch, Shanghai 202157, Peoples R China.
   [Xu, Shizan; Yu, Qiang; Liu, Ning] Nanjing Med Univ, Shanghai Peoples Hosp 10, Sch Clin Med, Shanghai 200072, Peoples R China.
   [Xu, Ling] Shanghai Jiao Tong Univ, Shanghai Tongren Hosp, Sch Med, Dept Gastroenterol, Shanghai 200336, Peoples R China.
   [Wang, Fan] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Sch Med, Dept Oncol, Shanghai 200080, Peoples R China.
   [Dai, Weiqi] Fudan Univ, Zhongshan Hosp, Dept Gastroenterol, Shanghai 200032, Peoples R China.
   [Dai, Weiqi] Fudan Univ, Zhongshan Hosp, Shanghai Inst Liver Dis, Shanghai 200032, Peoples R China.
   [Fan, Xiaoming] Fudan Univ, Jinshan Hosp, Dept Gastroenterol, 1508 Longhang Rd, Shanghai 201508, Peoples R China.
C3 Tongji University; Tongji University; Nanjing Medical University;
   Shanghai Jiao Tong University; Shanghai Jiao Tong University; Fudan
   University; Fudan University; Fudan University
RP Guo, CY (corresponding author), Tongji Univ, Shanghai Peoples Hosp Affiliated 10, Sch Med, Dept Gastroenterol, 301 Middle Yanchang Rd, Shanghai 200072, Peoples R China.; Fan, XM (corresponding author), Fudan Univ, Jinshan Hosp, Dept Gastroenterol, 1508 Longhang Rd, Shanghai 201508, Peoples R China.
EM xiaomingfan57@hotmail.com; guochuanyong@hotmail.com
RI ; Wang, Fan/HGC-0461-2022; Dai, Weiqi/L-7545-2019; Feng,
   Jiao/AFS-6380-2022
OI , Liwei/0000-0003-0322-722X; Feng, Jiao/0000-0001-5344-7242; Li,
   Sainan/0000-0002-1880-6294; Guo, Chuanyong/0000-0002-6527-4673
FU National Natural Science Foundation of China [81670472, 81700502,
   81500466]
FX This study was supported by the National Natural Science Foundation of
   China (grant nos. 81670472, 81700502 and 81500466).
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NR 58
TC 37
Z9 45
U1 0
U2 33
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JUN
PY 2018
VL 15
IS 6
BP 4599
EP 4614
DI 10.3892/etm.2018.6053
PG 16
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GJ3FB
UT WOS:000435174400001
PM 29805476
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, C
   Lin, BB
   Qi, SS
   He, J
   Zheng, HX
AF Chen, Chen
   Lin, Beibei
   Qi, Shanshan
   He, Jia
   Zheng, Hongxing
TI Protective Effects of Salidroside on Lead Acetate-induced Oxidative
   Stress and Hepatotoxicity in Sprague-Dawley Rats
SO BIOLOGICAL TRACE ELEMENT RESEARCH
LA English
DT Article
DE Salidroside; Lead; Hepatotoxicity; Oxidative stress
ID INDUCED LIVER-INJURY; EXTRACT; GLUTATHIONE; DAMAGE; HYPERLIPIDEMIA;
   ANTIOXIDANTS; SYSTEM
AB Lead has heavy metal toxicity which endangers human and animal health. Salidroside (SDS) is a natural antioxidant that has extensive pharmacological usage. However, its protective effects on lead-induced oxidative stress and hepatotoxicity has not been reported. In this study, we established an animal model to evaluate the protective effects of SDS on chronic lead exposure induced oxidative stress and hepatotoxicity. Forty healthy Sprague-Dawley (SD) rats were assigned to control group (control, animals were provided with distilled water, n = 10); lead acetate-exposed group (PbAc, animals received lead acetate solution of 500 ppm for 60 days, n = 10); low dosage of SDS-treated group (PbAc-SDS-L, lead acetate exposed animals were given intragastric SDS 150 mg/kg body weight for 60 days, n = 10); and high dosage of SDS-treated group (PbAc-SDS-H, lead acetate exposed animals were given intragastric SDS 300 mg/kg body weight for 60 days, n = 10). The results showed that lead exposure caused a significant increase in serum ALP, AST, ALT, and TB (P < 0.01), and these were reversed after treatment with salidroside for 60 days. Compared to the control, the liver GSH, SOD, and GSH-Px were decreased significantly after lead acetate exposure (P < 0.01). However, after treatment with SDS for 60 days, those were dose-dependently reversed. Similarly, MDA was significantly increased in the PbAc group (P < 0.01), and it was significantly decreased in SDS treatment group. Moreover, SDS ameliorated lead-induced congestion and necrosis of hepatocytes. In addition, the RT-PCR and immunohistochemistry results revealed that the PbAc group showed a significant increase in the protein and mRNA of cytochrome P450 2E1 (CYP2E1) and NADPH oxidase 2 (NOX2) in rat liver. Treatment with SDS significantly reversed CYP2E1 and NOX2 expressions in the liver of lead-exposed rats. The results above indicated that SDS has obvious antioxidant activity; it can cure liver injury caused by lead acetate by inhibiting oxidative stress and increasing the antioxidant stress activity, thus improving the liver tissue structure.
C1 [Chen, Chen; Lin, Beibei; Zheng, Hongxing] Shaanxi Univ Technol, Coll Biol Sci & Engn, Chinese German Joint Lab Nat Prod Res, Chaoyang Rd, Hanzhong 723000, Shaanxi, Peoples R China.
   [Qi, Shanshan; He, Jia] Shaanxi Univ Technol, Vitamin D Res Inst, Chaoyang Rd, Hanzhong 723000, Shaanxi, Peoples R China.
   [Qi, Shanshan; He, Jia] Collaborat Innovat Ctr, Qinling Bashan Mt Bioresources Comprehens Dev, Hanzhong 723000, Shaanxi, Peoples R China.
C3 Shaanxi University of Technology; Shaanxi University of Technology
RP Zheng, HX (corresponding author), Shaanxi Univ Technol, Coll Biol Sci & Engn, Chinese German Joint Lab Nat Prod Res, Chaoyang Rd, Hanzhong 723000, Shaanxi, Peoples R China.; Qi, SS (corresponding author), Shaanxi Univ Technol, Vitamin D Res Inst, Chaoyang Rd, Hanzhong 723000, Shaanxi, Peoples R China.; Qi, SS (corresponding author), Collaborat Innovat Ctr, Qinling Bashan Mt Bioresources Comprehens Dev, Hanzhong 723000, Shaanxi, Peoples R China.
EM qishanshan101@126.com; zhenghongxing100@126.com
RI /D-7472-2011
OI Shanshan, Qi/0000-0003-1636-3060
FU High-end Foreign Experts Recruitment Programme of State Administration
   of Foreign Experts Affairs [GDT20186100426]; Shaanxi Province Key
   Research and Development Plan [2017SF-074]; Qinling-Bashan Mountains
   Bioresources Comprehensive Development Collaborative Innovation Center
   Research Funds [QBXT-17-9]; key Project of Agricultural Science and
   Technology of Shaanxi Province [2017NY-082]; Postdoctoral Program in
   Shaanxi University of Technology [SLGBH16-03]
FX The authors received funding from the High-end Foreign Experts
   Recruitment Programme of State Administration of Foreign Experts Affairs
   (GDT20186100426), Shaanxi Province Key Research and Development Plan
   (2017SF-074), Qinling-Bashan Mountains Bioresources Comprehensive
   Development Collaborative Innovation Center Research Funds (QBXT-17-9),
   the key Project of Agricultural Science and Technology of Shaanxi
   Province (2017NY-082), and Postdoctoral Program in Shaanxi University of
   Technology (SLGBH16-03).
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NR 40
TC 45
Z9 53
U1 0
U2 31
PU HUMANA PRESS INC
PI TOTOWA
PA 999 RIVERVIEW DRIVE SUITE 208, TOTOWA, NJ 07512 USA
SN 0163-4984
EI 1559-0720
J9 BIOL TRACE ELEM RES
JI Biol. Trace Elem. Res.
PD OCT
PY 2019
VL 191
IS 2
BP 426
EP 434
DI 10.1007/s12011-019-1635-8
PG 9
WC Biochemistry & Molecular Biology; Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Endocrinology & Metabolism
GA IS9SB
UT WOS:000482487100020
PM 30666592
DA 2026-05-27
ER

PT J
AU Shan, H
   Li, XH
   Ouyang, C
   Ke, HY
   Yu, XL
   Tan, JF
   Chen, JH
   Wang, CP
   Zhang, LP
   Tang, YF
   Yu, L
   Li, WW
AF Shan, Hui
   Li, Xiaohong
   Ouyang, Chuan
   Ke, Hongyang
   Yu, Xiaoli
   Tan, Jinfeng
   Chen, Junhao
   Wang, Chunping
   Zhang, Liping
   Tang, Yunfeng
   Yu, Li
   Li, Wanwei
TI Salidroside prevents PM2.5-induced BEAS-2B cell apoptosis via
   SIRT1-dependent regulation of ROS and mitochondrial function
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Article
DE Salidroside; PM2; 5; Apoptosis; MPP; ROS; SIRT1-PGC-1 alpha
ID FINE PARTICULATE MATTER; OXIDATIVE STRESS; AIR-POLLUTION; IN-VITRO;
   PROTECTS; PM2.5; AUTOPHAGY; PATHWAY; INJURY; EXPOSURE
AB PM2.5 is a harmful air pollutant currently threatening public health. It has been closely linked to increased morbidity of bronchial asthma and lung cancer worldwide. Salidroside (Sal), an active component extracted from Rhodiola rosea, has been reported to ameliorate the progression of asthma. However, there are few studies on the protective effect of salidroside on PM2.5-induced bronchial epithelial cell injury, and the related molecular mechanism is not clear. Here, we aimed to explore the protective effect and related mechanism of Sal on PM2.5 bronchial injury. We chose 50 mu g/mL PM2.5 for 24 h as a PM2.5-induced cell damage model. After that BEAS-2B cells were pretreated with 40, 80, 160 mu M Sal for 24 h and then exposed to 50 mu g/mL PM2.5 for 24 h. We found that Sal pretreatment significantly inhibited the decrease of cell viability induced by PM2.5. Sal was effective in preventing PM2.5-induced apoptotic features, including Ca2+ overload, the cleavages of caspase 3, and the increases in levels of caspase 9 and Bcl-2-associated X protein (Bax), ultimately, Sal significantly inhibited PM2.5 induced apoptosis. Sal improved mitochondrial membrane potential, inhibited the release of cytochrome c from the mitochondria to cytoplasm. Sal alleviated ROS production, decreased the level of MDA, prevented the reduction of CAT, SOD and GSH-Px and increased the expression of NF-E2-related factor 2 (Nrf2), HO-1 and superoxide dismutase 1 (SOD1) in cells exposed to PM2.5. Furthermore, Sal improved the decrease of SIRT1 and PGC-1 alpha expression levels caused by PM2.5. In addition, inhibition of SIRT1 by EX527 (SIRT1 inhibitor) reversed the protective effects of Sal, including the decrease of ROS level, the increase of membrane potential level and the decrease of apoptosis level. Thus, Sal may be regarded as a potential drug to prevent PM2.5-induced apoptosis of bronchial epithelial cells and other diseases with similar pathological mechanisms.
C1 [Shan, Hui; Ouyang, Chuan; Ke, Hongyang; Wang, Chunping; Zhang, Liping; Tang, Yunfeng; Li, Wanwei] Weifang Med Coll, Sch Publ Hlth, Dept Environm Hyg, Weifang, Peoples R China.
   [Yu, Xiaoli; Chen, Junhao] Key Lab Hlth Inspect & Quarantine, Weifang, Peoples R China.
   [Li, Xiaohong; Yu, Xiaoli; Chen, Junhao; Wang, Chunping; Zhang, Liping; Tang, Yunfeng; Li, Wanwei] Weifang Med Coll, Sch Publ Hlth, Publ Hlth Demonstrat Ctr, Weifang, Peoples R China.
   [Li, Xiaohong] Weifang Med Coll, Sch Publ Hlth, Dept Nutr & Food Hyg, Weifang, Peoples R China.
   [Tan, Jinfeng] Weifang Environm Monitoring Stn, Weifang, Peoples R China.
   [Yu, Li] Weifang Med Univ, Sch Basic Med, Weifang, Peoples R China.
C3 Shandong Second Medical University; Shandong Second Medical University;
   Shandong Second Medical University; Shandong Second Medical University
RP Li, WW (corresponding author), Weifang Med Coll, Sch Publ Hlth, Dept Environm Hyg, Weifang, Peoples R China.
EM lilili127@163.com
RI Chen, Junhao/LCD-2351-2024
FU Shandong science and technology project of traditional Chinese medicine
   [2020M077]; Shandong Provincial Natural Science Foundation, China
   [ZR2020MH336]; Shandong Medical and Health Science and Technology
   Development Plan Project [2019WS592]; Shandong Sino US sports economic
   and Health Engineering Cooperation Research Center Project
   [SDCA20191017]
FX Acknowledgments This study was supported by Shandong science and
   technology project of traditional Chinese medicine (No. 2020M077) ,
   Shandong Provincial Natural Science Foundation, China (No. ZR2020MH336)
   , Shandong Medical and Health Science and Technology Development Plan
   Project (No. 2019WS592) , Shandong Sino US sports economic and Health
   Engineering Cooperation Research Center Project (No. SDCA20191017) .
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NR 62
TC 92
Z9 106
U1 4
U2 57
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD FEB
PY 2022
VL 231
AR 113170
DI 10.1016/j.ecoenv.2022.113170
EA JAN 2022
PG 16
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA 0O6GB
UT WOS:000783621200003
PM 35026589
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Mei, HH
   Yan, N
AF Mei, Haohao
   Yan, Ni
TI Salidroside alleviates palmitic acid-induced hepatocyte injury by
   regulating the LILRB2-mediated autophagy pathway
SO IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL
LA English
DT Article
DE NASH; Salidroside; LILRB2; Autophagy
ID NASH
AB Non-alcoholic steatohepatitis (NASH) is a progressive form of non-alcoholic fatty liver disease (NAFLD), characterized by hepatic steatosis, inflammation, and fibrosis, which may advance to cirrhosis and hepatocellular carcinoma. Treatment options remain limited, underscoring the need to elucidate its mechanisms and develop effective therapeutics. Salidroside (Sal), a primary active compound of Rhodiola rosea, has shown potential in alleviating NASH, yet its underlying mechanisms are not fully understood. This study investigates whether Sal mitigates palmitic acid (PA)-induced hepatocyte injury by regulating the leukocyte immunoglobulin-like receptor B2 (LILRB2)-mediated autophagy pathway. In vitro NASH model were established by inducing AML-12 cells with PA. Cells were divided into control, PA, and PA + Sal groups. To validate the role of LILRB2, an LILRB2 overexpression group was included. Cell proliferation, apoptosis, inflammatory factors (TNF-alpha, IL-1 beta, IL-6), and autophagy-related proteins were detected. Autophagic flux was evaluated using mCherry-GFP-LC3B transfection. PA treatment significantly suppressed proliferation, promoted apoptosis and inflammation, and inhibited autophagy, indicated by decreased LC3B-II/Beclin-1 and accumulated p62. Sal reversed these effects. Mechanistically, Sal downregulated LILRB2 expression, which was upregulated by PA. Overexpressing LILRB2 counteracted Sal's beneficial effects. These findings reveal that Sal attenuates PA-induced injury by inhibiting LILRB2, enhancing autophagy, and reducing apoptosis and inflammation, suggesting LILRB2 as a potential therapeutic target for NASH.
C1 [Mei, Haohao] Jiaxing Univ, Dept Infect Dis, Affiliated Hosp 2, Jiaxing 314000, Zhejiang, Peoples R China.
   [Yan, Ni] China Coast Guard Hosp, Dept Internal Med, Jiaxing 314000, Zhejiang, Peoples R China.
C3 Jiaxing University
RP Mei, HH (corresponding author), Jiaxing Univ, Dept Infect Dis, Affiliated Hosp 2, Jiaxing 314000, Zhejiang, Peoples R China.
EM mhh757703994@163.com
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NR 31
TC 0
Z9 0
U1 6
U2 6
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1071-2690
EI 1543-706X
J9 IN VITRO CELL DEV-AN
JI In Vitro Cell. Dev. Biol.-Anim.
PD JAN
PY 2026
VL 62
IS 1
BP 33
EP 44
DI 10.1007/s11626-025-01139-7
EA DEC 2025
PG 12
WC Cell Biology; Developmental Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Developmental Biology
GA FB2DO
UT WOS:001638849100001
PM 41398524
OA Bronze
DA 2026-05-27
ER

PT J
AU Kumar, S
   Das, A
AF Kumar, Sunil
   Das, Asmita
TI A Cocktail of Natural Compounds Holds Promise for New Immunotherapeutic
   Potential in Head and Neck Cancer
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Article
DE natural compounds; chemopreventive; gene expression; head and neck
   cancer; immunomodulator; salidroside; ginsenoside Rd; oridonin;
   britanin; scutellarein
ID IN-VITRO; GINSENOSIDE RD; SALIDROSIDE; MECHANISMS; ORIDONIN;
   CHEMOPREVENTION; ACTIVATION; PROTEIN; SAFETY
AB ObjectiveTo obtain detailed understanding on the gene regulation of natural compounds in altering prognosis of head and neck squamous cell carcinomas (HNSC).MethodsGene expression data of HNSC samples and peripheral blood mononuclear cells (PBMCs) of HNSC patients were collected from Gene Expression Omnibus (GEO). Differential gene expression analysis of GEO datasets were achieved by the GEO2R tool. Common differentially expressed gerres (DEGs) were screened by comparing DEGs of HNSC with those of PBMCs. The combination was further analyzed for regulating pathways and biological processes that were affected.ResultsTotally 110 DEGs were retrieved and identified to be involved in biological processes related to tumor regulation. Then 102 natural compounds were screened for a combination such that the expression of all 110 commonly DEGs was altered. A combination of salidroside, ginsenoside Rd, oridonin, britanin, and scutellarein was chosen. A multifaceted, multi-dimensional tumor regression was showed by altering autophagy, apoptosis, inhibiting cell proliferation, angiogenesis, metastasis and inflammatory cytokines production.ConclusionsThis study has helped develop a unique combination of natural compounds that will markedly reduce the propensity of development of drug resistance in tumors and immune evasion by tumors. The result is crucial to developing a combinatorial natural therapeutic cocktail with accentuated immunotherapeutic potential.
C1 [Kumar, Sunil; Das, Asmita] Delhi Technol Univ, Dept Biotechnol, Delhi 110042, India.
C3 Delhi Technological University
RP Das, A (corresponding author), Delhi Technol Univ, Dept Biotechnol, Delhi 110042, India.
EM asmita1710@gmail.com
RI kumar, sunil/KQU-5914-2024
OI kumar, sunil/0009-0004-6579-6019
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NR 61
TC 5
Z9 6
U1 0
U2 8
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1672-0415
EI 1993-0402
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD JAN
PY 2024
VL 30
IS 1
BP 42
EP 51
DI 10.1007/s11655-023-3694-0
EA APR 2023
PG 10
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA DB3N7
UT WOS:000980554800002
PM 37118529
DA 2026-05-27
ER

PT J
AU Xu, ZW
   Chen, X
   Jin, XH
   Meng, XY
   Zhou, X
   Fan, FX
   Mao, SY
   Wang, Y
   Zhang, WC
   Shan, NN
   Li, YM
   Xu, RC
AF Xu, Zhong-Wei
   Chen, Xi
   Jin, Xiao-Han
   Meng, Xiang-Yan
   Zhou, Xin
   Fan, Feng-Xu
   Mao, Shi-Yun
   Wang, Yue
   Zhang, Wen-Cheng
   Shan, Na-Na
   Li, Yu-Ming
   Xu, Rui-Cheng
TI SILAC-based proteomic analysis reveals that salidroside antagonizes
   cobalt chloride-induced hypoxic effects by restoring the tricarboxylic
   acid cycle in cardiomyocytes
SO JOURNAL OF PROTEOMICS
LA English
DT Article
DE Cobalt chloride; Salidroside; Hypoxic; SILAC; Quantitative proteomics
ID OXIDATIVE STRESS; MUSCLE-CELLS; EXPRESSION; PATHWAY; ROS;
   PHOSPHORYLATION; ACCUMULATION; METABOLISM; INDUCTION; APOPTOSIS
AB Hypoxic status alters the energy metabolism and induces cell injury in cardiomyocytes, and it further triggers the occurrence and development of cardiovascular diseases. Our previous studies have shown that salidroside (SAL) exhibits anti-hypoxic activity. However, the mechanisms remain obscure. In the present study, we successfully screened 92 different expression proteins in CoCl2-induced hypoxic conditions, 106 different expression proteins in the SAL-mediated anti-hypoxic group were compared with the hypoxic group using quantitative proteomics strategy, respectively. We confirmed that SAL showed a positive protective function involving the acetyl-CoA metabolic, tricarboxylic acid (TCA) cycle using bioinformatics analysis. We also demonstrated that SAL plays a critical role in restoring the TCA cycle and in protecting cardiomyocytes from oxidative injury via up-regulation expressions of PDHE1-B, ACO2, SUCLG1, SUCLG2 and down-regulation of MDH2. SAL also inhibited H9c2 cell apoptosis by inhibiting the activation of pro-apoptotic molecules caspase 3 and caspase 9 as well as activation of the anti-apoptotic molecular Bcl-2. Additionally, SAL also improved mitochondrial membrane potential (Delta Psi m), reduced reactive oxygen species (ROS) and intercellular Ca2+ concentration ([Ca2+]i) accumulation and inhibited the excessive consumption of ATP in H9c2 cells. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Xu, Zhong-Wei; Fan, Feng-Xu; Shan, Na-Na] Logist Univ Chinese Peoples Armed Police Force, Cent Lab, Beijing 300309, Peoples R China.
   [Chen, Xi; Mao, Shi-Yun; Wang, Yue; Xu, Rui-Cheng] Tianjin Key Lab Biomarkers Occupat & Environm Haz, Tianjin 300309, Peoples R China.
   [Jin, Xiao-Han; Zhou, Xin; Zhang, Wen-Cheng; Li, Yu-Ming] Tianjin Key Lab Cardiovasc Remodeling & Target Or, Tianjin 300162, Peoples R China.
   [Meng, Xiang-Yan] Logist Univ Chinese Peoples Armed Police Force, Dept Physiol & Pathophysiol, Tianjin 300309, Peoples R China.
RP Li, YM (corresponding author), Tianjin Key Lab Cardiovasc Remodeling & Target Or, Tianjin 300162, Peoples R China.
EM cardiolab@live.com; xu_rc@sohu.com
RI Zhou, Xin/AAH-7351-2019
OI Zhou, Xin/0000-0003-1395-7103
FU National Natural Science Foundation of China [81273552]; Tianjin Natural
   Science Foundation [12JCYBJC15900]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No.81273552) and Tianjin Natural Science
   Foundation12JCYBJC15900.
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NR 45
TC 46
Z9 53
U1 2
U2 68
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1874-3919
EI 1876-7737
J9 J PROTEOMICS
JI J. Proteomics
PD JAN 1
PY 2016
VL 130
BP 211
EP 220
DI 10.1016/j.jprot.2015.09.028
PG 10
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA CX0BS
UT WOS:000365362500021
PM 26435418
DA 2026-05-27
ER

PT J
AU Deng, WJ
   Lu, H
   Ren, XW
   Teng, JF
AF Deng, Wenjing
   Lu, Hong
   Ren, Xinwei
   Teng, Junfang
TI Effect of salidroside on learning and memory ability of vascular
   dementia rats
SO AFRICAN JOURNAL OF PHARMACY AND PHARMACOLOGY
LA English
DT Article
DE Salidroside; vascular dementia; rats
ID RHODIOLA-ROSEA EXTRACT; IN-VITRO; DYSFUNCTION; IMPAIRMENT; PLACEBO
AB The effect of salidroside (SD) on learning and memory ability of vascular dementia (VaD) rats were studied. The Wistar rats were randomly divided into six groups: Sham-operation group, VaD group, positive control (PC) group, SD high dose (SD-HD) treatment group, SD moderate dose (SD-MD) treatment group and SD low dose (SD-LD) treatment group. The bilateral common carotid arteries of Wistar rats were permanently ligated to established VaD models. The special study and memory were observed by Y-maze test. At postoperative 4, 8 and 12 weeks, error number (EN) and total reaction time (TRT) in the VaD, PC, SD-HD, SD-MD and SD-LD group were significantly more than those in the sham-operation group (P< 0.05 or 0.01), while EN and TRT in the PC, SD-HD, SD-MD and SD-LD groups were significantly less than those in the VaD group (P< 0.05 or 0.01). Compared with PC group, EN and TRT in SD-MD and SD-LD groups were also higher (P< 0.05 or 0.01). However, there were no significant differences in EN and TRT between PC and SD-HD groups (P> 0.05). These results suggested that SD could improve the learning and memory ability of VaD rats by different dosages.
C1 [Deng, Wenjing; Lu, Hong; Teng, Junfang] Zhengzhou Univ, Dept Neurol, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China.
   [Ren, Xinwei] Zhengzhou Univ, Dept Pharm, Affiliated Hosp 2, Zhengzhou 450014, Henan, Peoples R China.
C3 Zhengzhou University; Zhengzhou University
RP Teng, JF (corresponding author), Zhengzhou Univ, Dept Neurol, Affiliated Hosp 1, Zhengzhou 450052, Henan, Peoples R China.
EM teng450052@126.com
RI 邓, 文静/IAN-3615-2023
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NR 31
TC 0
Z9 0
U1 0
U2 11
PU ACADEMIC JOURNALS
PI VICTORIA ISLAND
PA P O BOX 5170-00200 NAIROBI, VICTORIA ISLAND, LAGOS 73023, NIGERIA
SN 1996-0816
J9 AFR J PHARM PHARMACO
JI Afr. J. Pharm. Pharmacol.
PD JAN
PY 2012
VL 6
IS 4
BP 264
EP 268
DI 10.5897/AJPP11.825
PG 5
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 938VG
UT WOS:000303760700007
OA gold
DA 2026-05-27
ER

PT J
AU Zhang, N
   Nao, J
   Dong, XY
AF Zhang, Nan
   Nao, Jianfei
   Dong, Xiaoyu
TI Neuroprotective Mechanisms of Salidroside in Alzheimer's Disease: A
   Systematic Review and Meta-analysis of Preclinical Studies
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Review
DE salidroside; Alzheimer's disease; neuroprotection; animal models;
   systematic review; meta-analysis
ID INDUCED COGNITIVE IMPAIRMENT; INDUCED RAT MODEL; OXIDATIVE STRESS;
   AMYLOID-BETA; CELL-DEATH; NEUROINFLAMMATION; TAU; MICROGLIA; NEURONS;
   TARGET
AB Alzheimer's disease (AD) is a neurodegenerative disease of the central nervous system that occurs in old age and pre-aging, characterized by progressive cognitive dysfunction and behavioral impairment. Salidroside (Sal) is a phenylpropanoid mainly isolated from Rhodiola species with various pharmacological effects. However, the exact anti-AD mechanism of Sal has not been clearly elucidated. This meta-analysis aims to investigate the possible mechanisms by which Sal exerts its anti-AD effects by evaluating behavioral indicators and biochemical characteristics. A total of 20 studies were included, and the results showed that the Sal treatment significantly improved behavior abnormalities in AD animal models. With regard to neurobiochemical indicators, Sal treatment could effectively increase the antioxidant enzyme superoxide dismutase, decrease the oxidative stress indicator malondialdehyde, and decrease the inflammatory indicators interleukin 1 beta, interleukin 6, and tumor necrosis factor alpha. Sal treatment was effective in reducing neuropathological indicators, such as amyloid-beta levels and the number of apoptotic cells. When the relevant literature on the treatment of rodent AD models is combined with Sal, the therapeutic potential of Sal through multiple mechanisms was confirmed. However, further confirmation by higher quality studies, larger sample sizes, and more comprehensive outcome evaluations in clinical trials is needed in the future.
C1 [Zhang, Nan] China Med Univ, Clin Coll 7, Dept Neurol, Fushun 113000, Liaoning, Peoples R China.
   [Nao, Jianfei; Dong, Xiaoyu] China Med Univ, Shengjing Hosp, Dept Neurol, Shenyang 110000, Liaoning, Peoples R China.
C3 China Medical University; China Medical University
RP Dong, XY (corresponding author), China Med Univ, Shengjing Hosp, Dept Neurol, Shenyang 110000, Liaoning, Peoples R China.
EM dongxy@sj-hospital.org
RI Zhang, Nan/B-2532-2016
OI Dong, Xiao Yu/0000-0003-3951-8037; Nao, Jianfei/0000-0002-9668-7032
FU Liaoning Province Livelihood Science and Technology Program
   [2021JH2/10300103]; Joint Plan of the Liaoning Province Livelihood
   Science and Technology Program
FX This study was supported by the Joint Plan of the Liaoning Province
   Livelihood Science and Technology Program (2021JH2/10300103).
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NR 97
TC 15
Z9 15
U1 3
U2 27
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD NOV 7
PY 2023
VL 71
IS 46
BP 17597
EP 17614
DI 10.1021/acs.jafc.3c06672
PG 18
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA Y9ND6
UT WOS:001108446200001
PM 37934032
DA 2026-05-27
ER

PT J
AU Ping, Z
   Zhang, LF
   Cui, YJ
   Chang, YM
   Jiang, CW
   Meng, ZZ
   Xu, P
   Liu, HY
   Wang, DY
   Cao, XB
AF Ping, Zheng
   Zhang, Long-fei
   Cui, Yu-juan
   Chang, Yu-mei
   Jiang, Cai-wu
   Meng, Zhen-zhi
   Xu, Peng
   Liu, Hai-yan
   Wang, Dong-ying
   Cao, Xue-bin
TI The Protective Effects of Salidroside from Exhaustive Exercise-Induced
   Heart Injury by Enhancing the
   PGC-1α-NRF1/NRF2 Pathway and Mitochondrial
   Respiratory Function in Rats
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID OXIDATIVE STRESS; BIOGENESIS; BIOPSIES; FIBERS; MUSCLE
AB Objective. To test the hypothesis that salidroside (SAL) can protect heart from exhaustive exercise-induced injury by enhancing mitochondrial respiratory function and mitochondrial biogenesis key signaling pathway PGC-1 alpha-NRF1/NRF2 in rats. Methods. Male Sprague-Dawley rats were divided into 4 groups: sedentary (C), exhaustive exercise (EE), low-dose SAL (LS), and high-dose SAL (HS). After one-time exhaustive swimming exercise, we measured the changes in cardiomyocyte ultrastructure and cardiac marker enzymes and mitochondrial electron transport system (ETS) complexes activities in situ. We also measured mitochondrial biogenesis master regulator PGC-1 alpha and its downstream transcription factors, NRF1 and NRF2, expression at gene and protein levels. Results. Compared to C group, the EE group showed marked myocardium ultrastructure injury and decrease of mitochondrial respiratory function (P < 0.05) and protein levels of PGC-1 alpha, NRF1, and NRF2 (P < 0.05) but a significant increase of PGC-1 alpha, NRF1, and NRF2 genes levels (P < 0.05); compared to EE group, SAL ameliorated myocardium injury, increased mitochondrial respiratory function (P < 0.05), and elevated both gene and protein levels of PGC-1 alpha, NRF-1, and NRF-2. Conclusion. Salidroside can protect the heart from exhaustive exercise-induced injury. It might act by improving myocardial mitochondrial respiratory function by stimulating the expression of PGC-1 alpha-NRF1/NRF2 pathway.
C1 [Ping, Zheng; Zhang, Long-fei; Cui, Yu-juan; Chang, Yu-mei; Xu, Peng; Liu, Hai-yan; Wang, Dong-ying; Cao, Xue-bin] 252 Hosp PLA, Dept Cardiol, Geriatr Cardiovasc Dis Res & Treatment Ctr, Baoding 071000, Peoples R China.
   [Jiang, Cai-wu] Guangxi Univ Chinese Med, Inst Chinese Mat Med, Nanning 530200, Peoples R China.
   [Meng, Zhen-zhi] Youjiang Med Univ Nationalities, Sch Preclin Med, Baise 533000, Guangxi, Peoples R China.
C3 Guangxi University of Chinese Medicine; Youjiang Medical University for
   Nationalities
RP Cao, XB (corresponding author), 252 Hosp PLA, Dept Cardiol, Geriatr Cardiovasc Dis Res & Treatment Ctr, Baoding 071000, Peoples R China.
EM caoxb252@163.com
RI jiang, caiwu/K-7173-2013; 常, 玉梅/K-6285-2015
OI jiang, caiwu/0000-0003-4930-8658; 
FU Natural Science Foundation of China [81173585]; Hebei Province Natural
   Science Foundation of China [C2014104010]
FX This research was supported by grants from the Natural Science
   Foundation of China (no. 81173585) and the Hebei Province Natural
   Science Foundation of China (no. C2014104010).
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NR 20
TC 82
Z9 94
U1 1
U2 30
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2015
VL 2015
AR 876825
DI 10.1155/2015/876825
PG 9
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA CM6TH
UT WOS:000357822400001
PM 26167242
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Mirmazloum, I
   Gyorgy, Z
AF Mirmazloum, I.
   Gyorgy, Z.
TI REVIEW OF THE MOLECULAR GENETICS IN HIGHER PLANTS TOWARDS SALIDROSID AND
   CINNAMYL ALCOHOL GLYCOSIDES BIOSYNTHESIS IN RHODIOLA ROSEA L.
SO ACTA ALIMENTARIA
LA English
DT Review
DE salidroside; cinnamyl alcohol glycosides; biosynthesis; molecular
   genetics; roseroot; Rhodiola rosea
ID PHENYLALANINE AMMONIA-LYASE; DOUBLE-BLIND; IN-VITRO; EXTRACT;
   BIOTRANSFORMATION; CLONING; PURIFICATION; EXPRESSION; CULTURES; PATHWAY
AB Rhodiola rosea L. (roseroot) has been categorized as an adaptogen and currently is one of the most studied medicinal plants for its enormous pharmaceutical significance and more reputably for its bioactive secondary metabolites, namely (rosin, rosavin, rosarin and salidroside). Roseroot is difficult to cultivate and develops very slowly in its natural environment, justifying development of new methods for production of its bioactive compounds. Different methods such as in vitro cell, tissue, and callus culture accompanied by some biotransformation trials have been carried out in the last two decades, but no feasible example has been developed for a large scale and industrial production of roseroot glycosides. To achieve a clear understanding of how to design any of roseroot in vitro culture systems to maximize the content of its specific natural products, the knowledge of a real biosynthetic pathway of these glycosides is necessary and indispensible. In this review article we are going to summarize the attainments and scientific results from molecular genetics of shikimate pathway in higher plants to give further clarification of salidroside and cinnamyl alcohol glycosides biosynthetic pathway. Considering all possibilities for these metabolites synthesis will help to think of alternative biotechnological methods for enhancing the biosynthesis of desired compounds in plants and more specifically in Rhodiola rosea L.
C1 [Mirmazloum, I.; Gyorgy, Z.] Corvinus Univ Budapest, Dept Genet & Plant Breeding, H-1118 Budapest, Hungary.
C3 Corvinus University Budapest
RP Mirmazloum, I (corresponding author), Corvinus Univ Budapest, Dept Genet & Plant Breeding, Menesi Ut 44, H-1118 Budapest, Hungary.
EM Iman.Mirmazloum@uni-corvinus.hu
RI György, Zsuzsanna/L-7105-2016; Mirmazloum, Iman/AAJ-5673-2020
OI György, Zsuzsanna/0000-0002-7803-5487; Mirmazloum,
   Iman/0000-0002-1461-0382
FU OTKA [PD83728];  [TAMOP-4.2.1/B-09/-KMR-2010-0005]
FX This work was co-financed by the TAMOP-4.2.1/B-09/-KMR-2010-0005 and
   OTKA PD83728 grants.
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NR 89
TC 13
Z9 13
U1 3
U2 87
PU AKADEMIAI KIADO ZRT
PI BUDAPEST
PA BUDAFOKI UT 187-189-A-3, H-1117 BUDAPEST, HUNGARY
SN 0139-3006
EI 1588-2535
J9 ACTA ALIMENT HUNG
JI Acta Aliment.
PD SEP
PY 2012
VL 41
SU 1
BP 133
EP 146
DI 10.1556/AAlim.41.2012.Suppl.13
PG 14
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 018RM
UT WOS:000309679800014
DA 2026-05-27
ER

PT J
AU Hu, TT
   Sun, QY
   Gou, Y
   Zhang, YR
   Ding, YM
   Ma, YR
   Liu, J
   Chen, W
   Lan, T
   Wang, PP
   Li, Q
   Yang, F
AF Hu, Tingting
   Sun, Qingyu
   Gou, Yu
   Zhang, Yurui
   Ding, Yumeng
   Ma, Yiran
   Liu, Jing
   Chen, Wen
   Lan, Ting
   Wang, Peipei
   Li, Qian
   Yang, Fei
TI Salidroside Alleviates Chronic Constriction Injury-Induced Neuropathic
   Pain and Inhibits of TXNIP/NLRP3 Pathway
SO NEUROCHEMICAL RESEARCH
LA English
DT Article
DE Salidroside; NLRP3 inflammasome; Neuropathic pain; TXNIP; Spinal cord
ID NLRP3 INFLAMMASOME; MECHANISMS; ACTIVATION; RATS
AB Neuropathic pain is one of the most common conditions requiring treatment worldwide. Salidroside (SAL), a phenylpropanoid glucoside extracted from Rhodiola, has been suggested to produce an analgesic effect in chronic pain. However, whether SAL could alleviate pain hypersensitivity after peripheral nerve injury and its mode of action remains unclear. Several studies suggest that activation of the spinal NOD-like receptor protein 3 (NLRP3) inflammasome and its related proteins contribute to neuropathic pain's pathogenesis. This study investigates the time course of activation of spinal NLRP3 inflammasome axis in the development of neuropathic pain and also whether SAL could be an effective treatment for this type of pain by modulating NLRP3 inflammasome. In the chronic constriction injury (CCI) mice model, spinal NLRP3 inflammasome-related proteins and TXNIP, the mediator of NLRP3, were upregulated from the 14th to the 28th day after injury. The TXNIP and NLRP3 inflammasome-related proteins were mainly present in neurons and microglial cells in the spinal dorsal horn after CCI. Intraperitoneal injection of SAL at 200 mg/kg for 14 consecutive days starting from the 7th day of CCI injury could ameliorate mechanical and thermal hypersensitivity in the CCI model. Moreover, SAL inhibited the activation of the TXNIP/NLRP3 inflammasome axis and mitigated the neuronal loss of spinal dorsal horn induced by nerve injury. These results indicate that SAL could produce analgesic and neuroprotective effects in the CCI model of neuropathic pain.
C1 [Hu, Tingting; Sun, Qingyu; Zhang, Yurui; Ding, Yumeng; Ma, Yiran; Liu, Jing; Chen, Wen; Wang, Peipei; Yang, Fei] Capital Med Univ, Dept Neurobiol, Sch Basic Med Sci, Adv Innovat Ctr Human Brain Protect,Beijing Key L, 10 You An Men Wai Xi Tou Tiao, Beijing 100069, Peoples R China.
   [Lan, Ting; Li, Qian] Capital Med Univ, Beijing Key Lab Neural Regenerat & Repair, Adv Innovat Ctr Human Brain Protect, Dept Biochem & Mol Biol,Sch Basic Med Sci, Beijing, Peoples R China.
   [Gou, Yu] Tianjin Univ, Tianjin Hosp, Dept Orthopaed Surg, Tianjin, Peoples R China.
C3 Capital Medical University; Capital Medical University; Tianjin
   University
RP Yang, F (corresponding author), Capital Med Univ, Dept Neurobiol, Sch Basic Med Sci, Adv Innovat Ctr Human Brain Protect,Beijing Key L, 10 You An Men Wai Xi Tou Tiao, Beijing 100069, Peoples R China.
EM feiyang@ccmu.edu.cn
RI ; Li, Qian/KIE-2130-2024; sun, qingyu/PAV-3475-2025
OI , Gou Yu/0000-0002-4110-5736; Li, Qian/0000-0003-0359-5604; Liu,
   Jing/0000-0001-7843-3883; 
FU National Natural Science Foundation of China [81971037]; Scientific
   Research Key Program of Beijing Municipal Commission of Education
   [KZ201910025026]; High-level Teachers in Beijing Municipal Universities
   in the Period of 13th Five-year Plan [CITTCD201904092]; Beijing Natural
   Science Foundation Program
FX This work was supported by National Natural Science Foundation of China
   (Grant No. 81971037 to F. Yang) the Beijing Natural Science Foundation
   Program and Scientific Research Key Program of Beijing Municipal
   Commission of Education (KZ201910025026 to F. Yang) and Support Project
   of High-level Teachers in Beijing Municipal Universities in the Period
   of 13th Five-year Plan CIT&TCD201904092 (QL).
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NR 37
TC 17
Z9 19
U1 0
U2 16
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD FEB
PY 2022
VL 47
IS 2
BP 493
EP 502
DI 10.1007/s11064-021-03459-y
EA OCT 2021
PG 10
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA YW5ZS
UT WOS:000705807200002
PM 34626306
DA 2026-05-27
ER

PT J
AU Li, FJ
   Yuan, Y
   Li, H
   Zhan, ZL
   Kang, LP
   Li, M
   Yang, B
   Huang, LQ
AF Li, Fajie
   Yuan, Yuan
   Li, Hua
   Zhan, Zhilai
   Kang, Liping
   Li, Man
   Yang, Bin
   Huang, Luqi
TI Infrared-assisted extraction of salidroside from the root of Rhodiola
   crenulata with a novel ionic liquid that dissolves cellulose
SO RSC ADVANCES
LA English
DT Article
ID WHEAT-STRAW; DISSOLUTION; OPTIMIZATION; LEAVES; POLYSACCHARIDES;
   ALKALOIDS; BIOMASS; RUTIN
AB Tetrabutylphosphonium hydroxide (TBPH) aqueous solution, a novel ionic liquid that could dissolve cellulose rapidly at ambient temperature (25 degrees C), was used for the first time to develop an extraction method for salidroside from Rhodiola crenulata, used as the model sample, with infrared-assisted extraction (IRAE) in this paper. IRAE-TBPH procedures were optimized using a series of single-factor experiments and under optimal conditions, the IRAE-TBPH technique not only took a shorter time (from 1.0 h to 8 min) but also afforded a higher extraction rate of salidroside from the herbs (increased by 15.41-38.65%) compared with other extraction techniques, such as TBPH-based heat reflux extraction (HRE-TBPH), ultrasound-assisted extraction (UAE-TBPH) and conventional solvent (methanol, ethanol and pure water) based IRAE. The results indicated IRAE-TBPH to be a fast and efficient extraction technique. Furthermore, the mechanism of IRAE-TBPH was preliminarily studied by means of the surface structures and chemical compositions of the samples before and after different extraction techniques. On the basis of the destruction of herb surface microstructures, the cellulose dissolving property of TBPH and high efficiency heating of infrared irradiation in the IRAE-TBPH process, the IRAE-TBPH technique eventually achieved the maximum yield value. Therefore, TBPH solution as a novel, effective and alternative solvent with higher extraction efficiency in the IRAE of active compounds from medicinal plants showed a great promising prospect.
C1 [Li, Fajie; Yuan, Yuan; Zhan, Zhilai; Kang, Liping; Li, Man; Huang, Luqi] China Acad Chinese Med Sci, Natl Resource Ctr Chinese Mat Med, State Key Lab Dao Di Herbs, Beijing 100700, Peoples R China.
   [Li, Hua; Yang, Bin] China Acad Chinese Med Sci, Inst Chinese Mat Med, Beijing 100700, Peoples R China.
C3 China Academy of Chinese Medical Sciences; National Resource Center for
   Chinese Materia Medica, CACMS; China Academy of Chinese Medical
   Sciences; Institute of Chinese Materia Medica, CACMS
RP Huang, LQ (corresponding author), China Acad Chinese Med Sci, Natl Resource Ctr Chinese Mat Med, State Key Lab Dao Di Herbs, 16 Nanxiaojie, Beijing 100700, Peoples R China.
EM ybinmm@hotmail.com; huangluqi@263.net
RI Kang, Liping/NTQ-3522-2025
FU Specific funds of TCM industry [201407003]; National High-tech Research
   and Development Program [SS2014AA022201]; National Science Fund for
   Distinguished Young Scholars [81325023]; central level significant
   increase or decrease support project; key project of the National
   Natural Science Foundation; Jiangsu university collaborative innovation
   project
FX This work was supported by the Specific funds of TCM industry (Grant no.
   201407003), National High-tech Research and Development Program (no.
   SS2014AA022201), National Science Fund for Distinguished Young Scholars
   (81325023), the central level significant increase or decrease support
   project, the key project of the National Natural Science Foundation and
   Jiangsu university collaborative innovation project.
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NR 43
TC 14
Z9 18
U1 5
U2 61
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
EI 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2015
VL 5
IS 59
BP 47326
EP 47333
DI 10.1039/c5ra07969a
PG 8
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA CJ7TX
UT WOS:000355703700008
DA 2026-05-27
ER

PT J
AU Duan, JY
   Zhao, Q
   Li, CB
   Nian, YQ
AF Duan, Jiaying
   Zhao, Qing
   Li, Chunbao
   Nian, Yingqun
TI Effects of salidroside on structural and functional properties of
   myofibrillar proteins in the Fenton system
SO MEAT SCIENCE
LA English
DT Article
DE Myofibrillar proteins; Salidroside; Protein oxidation; Fenton reaction;
   Structural characterization; Functional properties
ID CHLOROGENIC ACID; OXIDATION; GEL; CONFORMATION; GELATION
AB This study used the Fenton reaction to simulate the oxidation process of porcine myofibrillar proteins (MPs), aiming to explore the regulatory effect of salidroside (SAL) on the structure and functional properties of MPs under oxidative conditions. Systematic characterization of MPs-SAL interactions through biochemical assays, physicochemical measurements, and multispectral structural analysis. The results demonstrated that SAL boosted the antioxidant prowess of MPs in a dose-dependent fashion. Oxidative stress caused a reduction in sulfhydryl levels and absolute Zeta potential values, while simultaneously increasing dimeric tyrosine formation. Compared to the control group, sulfhydryl and dimerized tyrosine levels decreased with increasing SAL concentration, while the absolute Zeta potential values exhibited a progressive augmentation. Furthermore, oxidation resulted in elevated surface hydrophobicity and reduced solubility, and SAL further promoted the exposure of hydrophobic residues, and SAL caused changes in both the secondary and tertiary structures of MPs. SDS-PAGE revealed no notable band variations in oxidized groups following SAL treatment. Scanning electron microscopy revealed that the pores of MPs became larger and the surface rough after oxidation, while the protein surface became less wrinkled and smoother after the addition of SAL. In summary, the interaction between MPs and SAL affects the structural and functional properties of proteins.
C1 [Duan, Jiaying; Zhao, Qing; Li, Chunbao; Nian, Yingqun] Nanjing Agr Univ, State Key Lab Meat Qual Control & Cultured Meat De, Jiangsu Collaborat Innovat Ctr Meat Prod Proc & Qu, Coll Food Sci & Technol,MOST,MARA,Key Lab Meat Pro, Nanjing 210095, Peoples R China.
C3 Nanjing Agricultural University
RP Nian, YQ (corresponding author), Nanjing Agr Univ, Coll Food Sci & Technol, Binjiang Campus,Binjiang Ave 666, Nanjing 211800, Peoples R China.
EM nianyingqun@njau.edu.cn
RI wang, wangtianhao/OGQ-6441-2025
FU National Pig Industry Technology System [CARS35]
FX This work was supported by the National Pig Industry Technology System
   [grant no. CARS35] .
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NR 38
TC 0
Z9 0
U1 7
U2 9
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0309-1740
EI 1873-4138
J9 MEAT SCI
JI Meat Sci.
PD JAN
PY 2026
VL 231
AR 109976
DI 10.1016/j.meatsci.2025.109976
EA OCT 2025
PG 9
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 9JY5P
UT WOS:001608153600001
PM 41161030
DA 2026-05-27
ER

PT J
AU Zhao, SY
   Fang, L
   Yan, CX
   Wei, JH
   Song, D
   Xu, CY
   Luo, YH
   Fan, YC
   Guo, L
   Sun, H
   Guo, T
AF Zhao, Siyu
   Fang, Li
   Yan, Chenxi
   Wei, Jiahong
   Song, Dan
   Xu, Chenyu
   Luo, Yanhong
   Fan, Yuchen
   Guo, Li
   Sun, Hao
   Guo, Tao
TI MicroRNA-210-3p mediates trabecular meshwork extracellular matrix
   accumulation and ocular hypertension-Implication for novel glaucoma
   therapy
SO EXPERIMENTAL EYE RESEARCH
LA English
DT Article
DE Primary open -angle glaucoma; Extracellular matrix; Intraocular
   pressure; Salidroside; MicroRNA-210-3p
ID OPEN-ANGLE GLAUCOMA; INTRAOCULAR-PRESSURE; AQUEOUS-HUMOR; SALIDROSIDE;
   TGF-BETA-2; BLINDNESS
AB Elevation of intraocular pressure (IOP) is a major, controllable risk factor of primary open-angle glaucoma (POAG). Transforming growth factor-I32 (TGF-I32)-induced excessive accumulation of extracellular matrix (ECM) in the trabecular meshwork (TM) has been demonstrated to contribute significantly to the development of high IOP. We previously showed that treatment with salidroside (Sal), a plant-derived glucoside, can ameliorate the TGF-I32-induced ECM expression in cultured human TM cells and reduce TGF-I32-induced ocular hypertension in mice. In the current study, its underlying molecular mechanism associated with microRNA-210-3p (miR210-3p) was characterized. We discovered that, in TM tissues of POAG patients, there was an increase in miR210-3p. And miR-210-3p mediated a portion of the pathological effects of TGF-I32 in vitro (excessive accumulation of ECM in cultured human TM cells) and in vivo (mouse ocular hypertension and ECM accumulation in the TM). Most interestingly, miR-210-3p was down-regulated by Sal, which appeared to mediate a significant portion of its IOP-lowering effect. Thus, these results shed light on the probable molecular mechanisms of TGF-I32 and Sal and indicate that manipulation of miR-210-3p level/activity represents a potential new therapeutic strategy for POAG.
C1 [Zhao, Siyu; Fang, Li; Yan, Chenxi; Sun, Hao; Guo, Tao] Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Dept Ophthalmol, Shanghai 200011, Peoples R China.
   [Zhao, Siyu; Fang, Li; Yan, Chenxi; Sun, Hao; Guo, Tao] Shanghai Key Lab Orbital Dis & Ocular Oncol, Shanghai 200023, Peoples R China.
   [Zhao, Siyu; Song, Dan; Xu, Chenyu; Luo, Yanhong] Bengbu Med Coll, Bengbu 233030, Anhui, Peoples R China.
   [Wei, Jiahong] Tongji Hosp, Shanghai 200065, Peoples R China.
   [Fan, Yuchen] Bengbu Med Coll, Affiliated Hosp 1, Dept Ophthalmol, Bengbu 233000, Anhui, Peoples R China.
   [Guo, Li] Anhui Med Univ, Luan Hosp, Hefei 237000, Anhui, Peoples R China.
   [Guo, Li] Luan Peoples Hosp, Hefei 237000, Anhui, Peoples R China.
C3 Shanghai Jiao Tong University; Bengbu Medical University; Bengbu Medical
   University; Anhui Medical University
RP Sun, H; Guo, T (corresponding author), Shanghai Jiao Tong Univ, Peoples Hosp 9, Sch Med, Dept Ophthalmol, Shanghai 200011, Peoples R China.
EM Sunhao6666@126.com; guotao9@hotmail.com
RI Sun, Hao/AAX-1653-2020
FU Shanghai Industrial Collaborative Technology Innovation Project
   [XTCX-KJ-2022-35]; Science and Technology Commission of Shanghai
   [19411961500]; Clinical Research Program of 9th People's Hospital
   affiliated to Shanghai Jiao Tong University School of Medicine
   [JYLJ201804]; Fundamental Research Program Funding of Ninth People's
   Hospital affiliated to Shanghai Jiao Tong University School of Medicine
   [JYZZ121]; Innovative research team of high-level local universities in
   Shanghai [SHSMU-ZDCX20210902]; Natural Science Research Project of Anhui
   Educational Committee [KJ2021A0766]
FX This work was supported by Shanghai Industrial Collaborative Technology
   Innovation Project (# XTCX-KJ-2022-35) , the Science and Technology
   Commission of Shanghai (# 19411961500) , the Clinical Research Program
   of 9th People's Hospital affiliated to Shanghai Jiao Tong University
   School of Medicine (# JYLJ201804) , the Fundamental Research Program
   Funding of Ninth People's Hospital affiliated to Shanghai Jiao Tong
   University School of Medicine (# JYZZ121) , the innovative research team
   of high-level local universities in Shanghai (SHSMU-ZDCX20210902) and
   the Natural Science Research Project of Anhui Educational Committee (#
   KJ2021A0766) .
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NR 44
TC 8
Z9 8
U1 0
U2 18
PU ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
PI LONDON
PA 24-28 OVAL RD, LONDON NW1 7DX, ENGLAND
SN 0014-4835
EI 1096-0007
J9 EXP EYE RES
JI Exp. Eye Res.
PD FEB
PY 2023
VL 227
AR 109350
DI 10.1016/j.exer.2022.109350
EA DEC 2022
PG 15
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA A3RP1
UT WOS:000954339700001
PM 36566010
DA 2026-05-27
ER

PT J
AU Liu, WQ
   Liu, AQ
   Wang, YF
   Yu, SX
   Feng, C
   Liu, WP
   Fang, Y
   Li, J
   Yu, HD
   Liu, JY
   Wang, WJ
   Ding, JY
   Lü, P
   Zhao, LP
   Luo, LQ
   Liu, XZ
   Zuo, ZF
AF Liu, Wenqiang
   Liu, Anqi
   Wang, Yufei
   Yu, Shengxue
   Feng, Chuang
   Liu, Wanpeng
   Fang, Yan
   Li, Jing
   Yu, Hongdan
   Liu, Jiayou
   Wang, Wenjuan
   Ding, Jiayuan
   Lu, Pan
   Zhao, Lipan
   Luo, Linqin
   Liu, Xuezheng
   Zuo, Zhongfu
TI Salidroside alleviates ferroptosis of retinal ganglion cells in
   db/db mice
SO FOOD SCIENCE AND HUMAN WELLNESS
LA English
DT Article
DE Diabetic retinopathy; Retinal ganglion cells; Ferroptosis; Salidroside
ID INJURY; STRESS
AB Salidroside (Sal), is one of the important food supplements from the traditional Chinese medicine Integripetal rhodiola herb, encapsulating significant anti-oxidative stress, anti-ferroptosis, and neuroprotective attributes. Notwithstanding these latent virtues, the ramifications of Sal on retinal ganglion cells (RGCs) impairment during the incipient stages of diabetic retinopathy (DR) remain equivocal. The purpose of this study was to investigate inhibitory effect of Sal on ferroptosis of RGCs in db/db mice. Within the research conducted, Sal was administered via gavage, and observations were made 8 weeks post-treatment. Retinal samples were collected for analysis. The results evidenced that Sal ameliorated blood glucose levels, attenuated RGCs destruction, and augmented visual functionality in db/db mice. Additionally, Sal exerted an anti-ferroptosis impact on the RGCs in the db/db mice. Successive discoveries have outlined the involvement of the HIF-1 alpha/HO-1 signaling pathway in this protective mechanism. Ferroptosis of RGCs has a contributory effect on the development of DR, in part through the HIF-1 alpha/HO-1 pathway. Intriguingly, Sal reversed the alterations in the HIF-1 alpha/HO-1 pathway in db/db mice and displayed prospective advantageous effects on DR. Sal mitigated RGCs ferroptosis by reducing blood sugar and impeding the HIF-1 alpha/HO-1 signaling pathway, thereby improving DR. Thus, Sal shows potential for use as a pharmaceutical and nutraceutical for DR.
C1 [Liu, Wenqiang; Liu, Anqi; Wang, Yufei; Feng, Chuang; Fang, Yan; Ding, Jiayuan; Liu, Xuezheng; Zuo, Zhongfu] Jinzhou Med Univ, Sch Basic Med, Dept Anat, Jinzhou 121001, Peoples R China.
   [Liu, Wenqiang; Yu, Shengxue; Liu, Wanpeng; Li, Jing; Yu, Hongdan; Liu, Jiayou; Wang, Wenjuan; Liu, Xuezheng; Zuo, Zhongfu] Jinzhou Med Univ, Liaoning Key Lab Diabetic Cognit & Percept Dysfunc, Jinzhou 121001, Peoples R China.
   [Lu, Pan; Zhao, Lipan] Tianjin Med Univ Canc Inst & Hosp, Natl Clin Res Ctr Canc, Tianjin 300202, Peoples R China.
   [Luo, Linqin] Xi An Jiao Tong Univ, Hlth Sci Ctr, Xian 710061, Peoples R China.
C3 Jinzhou Medical University; Jinzhou Medical University; Tianjin Medical
   University; Xi'an Jiaotong University
RP Liu, XZ; Zuo, ZF (corresponding author), Jinzhou Med Univ, Sch Basic Med, Dept Anat, Jinzhou 121001, Peoples R China.
EM liuxuezheng@jzmu.edu.cn; zuozhongfu@jzmu.edu.cn
FU Basic Research Project for Higher Education Institutions of Liaoning
   Provincial Department of Education (Youth Project) [LJ212410160055];
   National Natural Science Foundation of China [81571383]; Foundation of
   Education Department of Liaoning Province of China [LJKMZ20221241];
   Natural Science Foundation of Liaoning Province of China [2023-MS-312]
FX This work was supported by the Basic Research Project for Higher
   Education Institutions of Liaoning Provincial Department of Education
   (Youth Project) (LJ212410160055); The National Natural Science
   Foundation of China (81571383); Foundation of Education Department of
   Liaoning Province of China (LJKMZ20221241); Natural Science Foundation
   of Liaoning Province of China (2023-MS-312).
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NR 43
TC 0
Z9 0
U1 7
U2 9
PU TSINGHUA UNIV PRESS
PI BEIJING
PA B605D, XUE YAN BUILDING, BEIJING, 100084, PEOPLES R CHINA
EI 2213-4530
J9 FOOD SCI HUM WELL
JI Food Sci. Human Wellness
PD JUN
PY 2025
VL 14
IS 6
AR 9250349
DI 10.26599/FSHW.2024.9250349
PG 16
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA 6WI2Z
UT WOS:001563568100002
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Pomari, E
   Stefanon, B
   Colitti, M
AF Pomari, Elena
   Stefanon, Bruno
   Colitti, Monica
TI Effects of Two Different Rhodiola rosea Extracts on Primary Human
   Visceral Adipocytes
SO MOLECULES
LA English
DT Article
DE human visceral adipocytes; differentiation; gene expression; Rhodiola
   rosea
ID TO-MODERATE DEPRESSION; PPAR-GAMMA; PROMOTES ADIPOGENESIS; TRANSCRIPTION
   FACTORS; METABOLIC SYNDROME; SIGNALING PATHWAY; ADIPOSE-TISSUE;
   YERBA-MATE; RAT MODEL; SALIDROSIDE
AB Rhodiola rosea (Rro) has been reported to have various pharmacological properties, including anti-fatigue, anti-stress and anti-inflammatory activity. It is also known to improve glucose and lipid metabolism, but the effects of Rhodiola rosea on adipocyte differentiation and metabolism are not still elucidated. In this study the anti-adipogenic and lipolytic activity of two extracts of Rhodiola rosea, containing 3% salidroside (RS) or 1% salidroside and 3% rosavines (RR) on primary human visceral adipocytes was investigated. Pre-adipocytes were analyzed after 10 and 20 days of treatment during differentiation and after 7 days of treatment when they reached mature shape. The RS extract significantly induced higher apoptosis and lipolysis in comparison to control cells and to RR extract. In contrast, RR extract significantly reduced triglyceride incorporation during maturation. Differentiation of pre-adipocytes in the presence of RS and RR extracts showed a significant decrease in expression of genes involved in adipocyte function such as SLC2A4 and the adipogenic factor FGF2 and significant increase in expression of genes involved in inhibition of adipogenesis, such as GATA3, WNT3A, WNT10B. Furthermore RR extract, in contrast to RS, significantly down-regulates PPARG, the master regulator of adipogenesis and FABP4. These data support the lipolytic and anti-adipogenetic activity of two different commercial extracts of Rhodiola rosea in primary human visceral pre-adipocytes during differentiation.
C1 [Pomari, Elena; Stefanon, Bruno; Colitti, Monica] Univ Udine, Dept Agr & Environm Sci, I-33100 Udine, Italy.
C3 University of Udine
RP Colitti, M (corresponding author), Univ Udine, Dept Agr & Environm Sci, Via Sci 206, I-33100 Udine, Italy.
EM elena.pomari@gmail.com; bruno.stefanon@uniud.it; monica.colitti@uniud.it
RI ; Pomari, Elena/J-8184-2018
OI colitti, monica/0000-0002-1775-3880; Pomari, Elena/0000-0002-5182-0231;
   stefanon, bruno/0000-0002-7414-5830
FU  [ART. 13 D.LGS 297/99]
FX This work was supported by Progetto ART. 13 D.LGS 297/99, Italy.
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NR 84
TC 28
Z9 32
U1 0
U2 36
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD MAY
PY 2015
VL 20
IS 5
BP 8409
EP 8428
DI 10.3390/molecules20058409
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA CL7NA
UT WOS:000357157600058
PM 25970041
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xu, ZW
   Fan, KY
   Li, H
   Wang, LL
   Zhu, WQ
   Zou, S
   Zhang, Y
   Liu, YN
   Wu, ZD
   Gong, Q
   Tan, MJ
   Wang, J
   Zhai, LH
AF Xu, Zhongwei
   Fan, Kaiyuan
   Li, Heng
   Wang, Lulu
   Zhu, Wenqing
   Zou, Shuang
   Zhang, Yan
   Liu, Yanan
   Wu, Zhidong
   Gong, Qian
   Tan, Minjia
   Wang, Jin
   Zhai, Linhui
TI The application of proteomics and phosphoproteomics to reveal the
   molecular mechanism of salidroside in ameliorating myocardial hypoxia
SO HELIYON
LA English
DT Article
DE Salidroside; Myocardial hypoxia; Proteome; Phosphoproteome; Aurora
   kinase
ID INJURY; PROTEINS; TARGET
AB Salidroside (SAL), belonging to a kind of the main active ingredient of Rhodiola rosea, is extensively utilized for anti-hypoxia and prevention of altitude sickness in the plateau region of China. However, the research on the systemic changes induced by SAL at intracellular protein level is still limited, especially at protein phosphorylation level. These limitations hinder a comprehensive understanding of the regulatory mechanisms of SAL. This study aimed to investigate the potential molecular mechanism of SAL in ameliorating the acute myocardial hypoxia induced by cobalt chloride using integrated proteomics and phosphoproteomics. We successfully identified 165 differentially expressed proteins and 266 differentially expressed phosphosites in H9c2 cells following SAL treatment under hypoxic conditions. Bioinformatics analysis and biological experiment validation revealed that SAL significantly antagonized CoCl2-mediated cell cycle arrest by downregulating CCND1 expression and upregulating AURKA, AURKAB, CCND3 and PLK1 expression. Additionally, SAL can stabilize the cytoskeleton through upregulating the Kinesin Family (KIF) members expression. Our study systematically revealed that SAL had the ability to protect myocardial cells against CoCl2-induced hypoxia through multiple biological pathways, including enhancing the spindle stability, maintaining the cell cycle, relieving DNA damage, and antagonizing cell apoptosis. This study supplies a comprehension perspective on the alterations at protein and protein phosphorylation levels induced by SAL treatment, thereby expanded our knowledge of the anti-hypoxic mechanisms of SAL. Moreover, this study provides a valuable resource for further investigating the effects of SAL.
C1 [Xu, Zhongwei; Fan, Kaiyuan; Li, Heng; Zhu, Wenqing; Zou, Shuang; Zhang, Yan; Liu, Yanan; Wu, Zhidong] Logist Univ Chinese Peoples Armed Police Force, Cent Lab, Tianjin 300309, Peoples R China.
   [Fan, Kaiyuan; Zhai, Linhui] Tongji Univ, Shanghai Peoples Hosp 4, Translat Res Inst Brain & Brain Like Intelligence, Sch Med, Shanghai 200434, Peoples R China.
   [Li, Heng; Gong, Qian; Wang, Jin] Tianjin Third Cent Hosp, Dept Clin Lab, Tianjin 300170, Peoples R China.
   [Wang, Lulu; Tan, Minjia; Zhai, Linhui] Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Pharmaceut Res, Shanghai 201203, Peoples R China.
   [Zhai, Linhui] Jiangsu Ocean Univ, Coll Pharm, Jiangsu Key Lab Marine Pharmaceut Cpd Screening, Lianyungang 222005, Peoples R China.
C3 Tongji University; Tianjin University; Chinese Academy of Sciences;
   Shanghai Institute of Materia Medica, CAS; Jiangsu Ocean University
RP Wang, J (corresponding author), Tianjin Third Cent Hosp, Dept Clin Lab, Tianjin 300170, Peoples R China.; Zhai, LH (corresponding author), Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Pharmaceut Res, Shanghai 201203, Peoples R China.
EM wangjane0917@126.com; zhailinhui@simm.ac.cn
RI Wu, Zond/KLZ-5129-2024; WANG, LULU/JDD-7125-2023; Fan,
   Kaiyuan/PNG-4024-2026; Tan, Minjia/C-4491-2014
FU National Natural Science Foundation of China [32171434]; PLA Medical
   Science and technology youth training program [18QNP044]; China People's
   Armed Regular Forces Personnel Project Plan [ZZKY20222308]; Science and
   Technology Commission of Qingpu District, Shanghai [QKY2021-02];
   Doctoral Fund of Qingpu Branch of Zhongshan Hospital Affiliated to Fudan
   University [IDQYBS2022-02]
FX This study was supported by grants from the National Natural Science
   Foundation of China (No.32171434) , the PLA Medical Science and
   technology youth training program (No.18QNP044) , the China People's
   Armed Regular Forces Personnel Project Plan (ZZKY20222308) , the Science
   and Technology Commission of Qingpu District, Shanghai (QKY2021-02) ,
   the Doctoral Fund of Qingpu Branch of Zhongshan Hospital Affiliated to
   Fudan University (IDQYBS2022-02) .
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NR 53
TC 2
Z9 4
U1 6
U2 21
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD MAY 15
PY 2024
VL 10
IS 9
AR e30433
DI 10.1016/j.heliyon.2024.e30433
EA MAY 2024
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA TC2N3
UT WOS:001238995000001
PM 38737233
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, SS
   Lu, YC
   Ding, DF
   Ma, ZZ
   Xing, XX
   Hua, XY
   Xu, JG
AF Li, Sisi
   Lu, Yechen
   Ding, Daofang
   Ma, Zhenzhen
   Xing, Xiangxin
   Hua, Xuyun
   Xu, Jianguang
TI Fibroblast growth factor 2 contributes to the effect of salidroside on
   dendritic and synaptic plasticity after cerebral ischemia/reperfusion
   injury
SO AGING-US
LA English
DT Article
DE salidroside; fibroblast growth factors; dendrite; synaptic plasticity;
   stroke
ID NEURITE OUTGROWTH; ISCHEMIA; INFLAMMATION; STROKE; PATHWAY; SPINES;
   NEUROGENESIS; THRESHOLDS; ACTIVATION; MECHANISMS
AB Ischemic stroke, a serious neurological disease, is associated with cell death, axonal and dendritic plasticity, and other activities. Anti-inflammatory, anti-apoptotic, promote dendritic and synaptic plasticity are critical therapeutic targets after ischemic stroke. Fibroblast growth factor-2 (FGF2), which is involved in the cyclic adenosine monophosphate (cAMP)/protein kinase A (PKA)/CAMP response element (CRE)-binding protein (CREB) pathway, has been shown to facilitate dendritic and synaptic plasticity. Salidroside (Sal) has been reported to have anti-inflammatory, anti-oxidative, and anti-apoptotic effects; however, the underlying mechanisms of Sal in promoting dendritic and synaptic plasticity remain unclear. Here, the anti-inflammatory, anti-apoptotic, dendritic and synaptic plasticity effects of Sal were investigated in vitro in PC12 cells under oxygen-glucose deprivation/reoxygenation (OGD/R) conditions and in vivo in rats with middle cerebral artery occlusion/reperfusion (MCAO/R). We investigated the role of Sal in promoting dendritic and synaptic plasticity in the ischemic penumbra and whether the FGF2-mediated cAMP/PKA/CREB pathway was involved in this process. The present study demonstrated that Sal could significantly inhibit inflammation and apoptosis, and promote dendritic and synaptic plasticity. Overall, our study suggests that Sal is an effective treatment for ischemic stroke that functions via the FGF2-mediated cAMP/PKA/CREB pathway to promote dendritic and synaptic plasticity.
C1 [Li, Sisi; Lu, Yechen; Ma, Zhenzhen; Xing, Xiangxin; Xu, Jianguang] Shanghai Univ Tradit Chinese Med, Sch Rehabil Sci, Shanghai 201203, Peoples R China.
   [Li, Sisi; Lu, Yechen; Ding, Daofang; Ma, Zhenzhen; Xing, Xiangxin; Hua, Xuyun; Xu, Jianguang] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Dept Rehabil Med, Shanghai 200437, Peoples R China.
   [Xu, Jianguang] Fudan Univ, Huashan Hosp, Dept Hand Surg, Shanghai 200040, Peoples R China.
   [Hua, Xuyun] Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Dept Trauma & Orthoped, Shanghai 200437, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Fudan University; Shanghai University
   of Traditional Chinese Medicine
RP Xu, JG (corresponding author), Shanghai Univ Tradit Chinese Med, Sch Rehabil Sci, Shanghai 201203, Peoples R China.; Xu, JG (corresponding author), Shanghai Univ Tradit Chinese Med, Yueyang Hosp Integrated Tradit Chinese & Western, Dept Rehabil Med, Shanghai 200437, Peoples R China.; Xu, JG (corresponding author), Fudan Univ, Huashan Hosp, Dept Hand Surg, Shanghai 200040, Peoples R China.
EM jianguangxu@fudan.edu.cn
RI ; Xing, Xiangxin/HGD-2599-2022
OI Ding, Dao-Fang/0000-0003-4056-142X; lu, ye-chen/0000-0001-9727-753X;
   Hua, Xu-Yun/0000-0002-2935-7551
FU National Key R&D Program of China [2018YFC2001600]
FX This work was financially supported by the National Key R&D Program of
   China (2018YFC2001600).
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U2 15
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD JUN 15
PY 2020
VL 12
IS 11
BP 10951
EP 10968
DI 10.18632/aging.103308
PG 18
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA LY5PF
UT WOS:000540580800064
PM 32518214
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Yao, F
   Jiang, XY
   Qiu, L
   Peng, ZX
   Zheng, W
   Ding, LX
   Xia, XB
AF Yao, Fei
   Jiang, Xinyi
   Qiu, Ling
   Peng, Zixuan
   Zheng, Wei
   Ding, Lexi
   Xia, Xiaobo
TI Long-Term Oral Administration of Salidroside Alleviates Diabetic
   Retinopathy in db/db Mice
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE salidroside; diabetes; retinopathy; oxidative stress; vascular barrier;
   transcriptome
ID CELLS
AB Diabetic retinopathy (DR), a microvascular complication of diabetes mellitus, is the leading cause of vision loss in the working-age population worldwide. Unfortunately, current clinical treatments cannot completely prevent the occurrence and development of DR. Salidroside (Sal) is a medicinal supplement that has antioxidative and cytoprotective properties. This study aimed to investigate the therapeutic effect of Sal on DR. Briefly, Sal treatment was applied to wide-type mice and db/db mice (a widely used diabetic mice) at 25 mg/kg by oral gavage once daily from 8 weeks to 20 weeks. Mice's bodyweight, blood glucose, total cholesterol, triglyceride, high density lipoprotein and low density lipoprotein were recorded and analyzed. Retinal trypsin digestion and evans blue dye assay were used to detect retinal microvessel changes and function. Retinal glutathione and malondialdehyde content measurements were applied to assess retinal oxidative stress. Full-length transcriptome analysis was performed to explore the underlying mechanisms of Sal protection. Our results found that Sal treatment could successfully relieve blood glucose and blood lipid abnormalities, and reduce retinal oxidative stress level in diabetic mice. Also, Sal treatment repaired the abnormal transcriptome caused by diabetes, alleviated the microvascular lesion of the fundus in diabetic mice, and protected retinal normal barrier function. This study enriches the indications of Sal in the treatment of diabetic diseases, providing practical research ideas for the comprehensive preventions and treatments of DR.
C1 [Yao, Fei; Qiu, Ling; Peng, Zixuan; Zheng, Wei; Ding, Lexi; Xia, Xiaobo] Cent South Univ, Eye Ctr Xiangya Hosp, Changsha, Peoples R China.
   [Yao, Fei; Peng, Zixuan; Zheng, Wei; Ding, Lexi; Xia, Xiaobo] Hunan Key Lab Ophthalmol, Changsha, Peoples R China.
   [Yao, Fei; Qiu, Ling; Peng, Zixuan; Zheng, Wei; Ding, Lexi; Xia, Xiaobo] Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.
   [Jiang, Xinyi] Tsinghua Univ, Tsinghua Shenzhen Int Grad Sch, Biomfg Engn Lab, Shenzhen, Peoples R China.
C3 Central South University; Central South University; Tsinghua University;
   Tsinghua Shenzhen International Graduate School
RP Zheng, W; Ding, LX; Xia, XB (corresponding author), Cent South Univ, Eye Ctr Xiangya Hosp, Changsha, Peoples R China.; Zheng, W; Ding, LX; Xia, XB (corresponding author), Hunan Key Lab Ophthalmol, Changsha, Peoples R China.; Zheng, W; Ding, LX; Xia, XB (corresponding author), Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China.
EM zhengweiinxy@csu.edu.cn; lexiding@csu.edu.cn; xbxia21@csu.edu.cn
RI Xia, Xiaobo/KSL-6157-2024
OI Xia, Xiaobo/0000-0003-1720-7860; Yao, Fei/0000-0002-1769-9140
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PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD MAR 16
PY 2022
VL 13
AR 861452
DI 10.3389/fendo.2022.861452
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 0F8YO
UT WOS:000777642600001
PM 35370972
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhu, L
   Jia, F
   Wei, J
   Yu, Y
   Yu, TH
   Wang, YJ
   Sun, JH
   Luo, GH
AF Zhu, Lin
   Jia, Fang
   Wei, Jiang
   Yu, Yang
   Yu, Tianhong
   Wang, Yanjun
   Sun, Jianhui
   Luo, Guanghua
TI Salidroside protects against homocysteine-induced injury in human
   umbilical vein endothelial cells via the regulation of endoplasmic
   reticulum stress
SO CARDIOVASCULAR THERAPEUTICS
LA English
DT Article
DE Atherosclerosis; Endoplasmic reticulum stress; Endotheliocyte;
   Homocysteine; Salidroside
ID POLY(ADP-RIBOSE) POLYMERASE; APOPTOSIS; DISEASE; ATHEROSCLEROSIS;
   ACTIVATION; PROGRESSION; CLEAVAGE
AB IntroductionPrevious studies showed that homocysteine (Hcy) could injure vascular endothelial cells via several mechanisms, including its promotion of oxidative stress pathway and endoplasmic reticulum stress (ER stress) pathway. Salidroside (SAL) is an active component of Rhodiola rosea with documented antioxidative properties. Emerging evidence conformed that SAL attenuated Hcy-induced endothelial dysfunction by reducing oxidative stress. However, its role in ER stress pathway remains unclarified.
   AimsThe purpose of this study was to explore the mechanism of the protective effect of SAL on Hcy-induced endothelial dysfunction.
   ResultsPretreatment of the human umbilical vein endothelial cells (HUVECs) with SAL significantly reduced the cell damage effects brought by Hcy in a dose-dependent manner. Functional studies on the HUVECs found that SAL rescued the endoplasmic reticulum stress induced by Hcy. The underlying mechanisms involve the inhibition of Hcy-induced activation of binding protein (Bip) and C/EBP homologous protein (CHOP), as well as the phosphorylation of protein kinase RNA-like ER kinase (PERK) or inositol-requiring enzyme 1 alpha (IRE1).
   ConclusionsTaken together, these findings implicate that SAL could regulate ER stress pathway on the viability of endotheliocyte induced by Hcy in vitro. Our findings provide the first evidence that SAL plays an important role in endotheliocyte protection via suppressing ER stress pathway in HUVEC cells and that it may be a promising therapeutic target for atherosclerosis and cardiovascular disease.
C1 [Zhu, Lin; Jia, Fang; Yu, Tianhong; Wang, Yanjun; Sun, Jianhui] Soochow Univ, Dept Cardiol, Affiliated Hosp 3, Changzhou, Peoples R China.
   [Wei, Jiang; Yu, Yang; Luo, Guanghua] Soochow Univ, Comprehens Lab, Affiliated Hosp 3, Changzhou, Peoples R China.
C3 Soochow University - China; Soochow University - China
RP Sun, JH (corresponding author), Soochow Univ, Dept Cardiol, Affiliated Hosp 3, Changzhou, Peoples R China.; Luo, GH (corresponding author), Soochow Univ, Comprehens Lab, Affiliated Hosp 3, Changzhou, Peoples R China.
EM sunjianh@sohu.com; 13915898806@163.com
RI ; 贾, 方/KBD-3766-2024
OI Luo, Guanghua/0000-0001-8339-2828; 
FU National Science Foundation of China [81300220]; International Science
   and Technology Cooperation Program of Changzhou [CZ20160013]
FX National Science Foundation of China, Grant/Award Number: 81300220;
   International Science and Technology Cooperation Program of Changzhou,
   Grant/Award Number: CZ20160013
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NR 25
TC 31
Z9 36
U1 0
U2 83
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1755-5914
EI 1755-5922
J9 CARDIOVASC THER
JI Cardiovasc. Ther.
PD FEB
PY 2017
VL 35
IS 1
BP 33
EP 39
DI 10.1111/1755-5922.12234
PG 7
WC Cardiac & Cardiovascular Systems; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Pharmacology & Pharmacy
GA EG0AS
UT WOS:000390693500005
PM 27809414
OA Bronze
DA 2026-05-27
ER

PT J
AU Mastihubová, M
   Poláková, M
AF Mastihubova, Maria
   Polakova, Monika
TI A selective and mild glycosylation method of natural phenolic alcohols
SO BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
LA English
DT Article
DE diastereoselectivity; p-hydroxyphenylalkyl glycosides; mild promoters;
   natural products; 1,2-trans-glycosylation
ID BETA-D-GLUCOPYRANOSIDES; PHENYLPROPANOID GLYCOSIDES;
   CARBOHYDRATE-CHEMISTRY; ENZYMATIC-SYNTHESIS; SALIDROSIDE; CELLS;
   ANALOGS; ANTIOXIDANT; GLUCOSIDES; ACTIVATION
AB Several bioactive natural p-hydroxyphenylalkyl beta-D-glucopyranosides, such as vanillyl beta-D-glucopyranoside, salidroside and isoconiferin, and their glycosyl analogues were prepared by a simple reaction sequence. The highly efficient synthetic approach was achieved by utilizing acetylated glycosyl bromides as well as aromatic moieties and mild glycosylation promoters. The aglycones, p-O-acetylated arylalkyl alcohols, were prepared by the reduction of the corresponding acetylated aldehydes or acids. Various stereoselective 1,2-trans-O-glycosylation methods were studied, including the DDQ-iodine or ZnO-ZnCl2 catalyst combination. Among them, ZnO-iodine has been identified as a new glycosylation promoter and successfully applied to the stereoselective glycoside synthesis. The final products were obtained by conventional Zemplen deacetylation.
C1 [Mastihubova, Maria; Polakova, Monika] Slovak Acad Sci, Inst Chem, Dubravska Cesta 9, SK-84538 Bratislava, Slovakia.
C3 Slovak Academy of Sciences; Institute of Chemistry, SAS
RP Mastihubová, M (corresponding author), Slovak Acad Sci, Inst Chem, Dubravska Cesta 9, SK-84538 Bratislava, Slovakia.
EM chemjama@savba.sk
RI Mastihubova, Maria/OZG-0746-2025; Polakova, Monika/B-4637-2019
OI Mastihubova, Maria/0000-0003-3033-811X; Polakova,
   Monika/0000-0002-1125-4482
FU Slovak Research and Development Agency [APVV-846-12]; Scientific Grant
   Agency of the Ministry of Education of Slovak Republic; ERDF ("Centre of
   Excellence on Green Chemistry Methods and Processes", CEGreenI)
   [26240120001]; Slovak Academy of Sciences (VEGA) [2/0138/12]; ERDF
   ("Amplification of the Centre of Excellence on Green Chemistry Methods
   and Processes", CEGreenII) [2640120025]
FX This work was supported by the Slovak Research and Development Agency
   under the contract No. APVV-846-12, the Scientific Grant Agency of the
   Ministry of Education of Slovak Republic and Slovak Academy of Sciences
   (VEGA) under the project No. 2/0138/12 and the Research & Development
   Operational Programmes funded by the ERDF ("Centre of Excellence on
   Green Chemistry Methods and Processes", CEGreenI, Contract No.
   26240120001 as well as, Amplification of the Centre of Excellence on
   Green Chemistry Methods and Processes", CEGreenII, Contract No.
   2640120025). The authors thank I. Uhliarikova for NMR measurements, S.
   Bekesova and S. Vlckova for mass measurements.
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NR 40
TC 11
Z9 12
U1 0
U2 36
PU BEILSTEIN-INSTITUT
PI FRANKFURT AM MAIN
PA TRAKEHNER STRASSE 7-9, FRANKFURT AM MAIN, 60487, GERMANY
SN 1860-5397
J9 BEILSTEIN J ORG CHEM
JI Beilstein J. Org. Chem.
PD MAR 15
PY 2016
VL 12
BP 524
EP 530
DI 10.3762/bjoc.12.51
PG 7
WC Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA DH1HS
UT WOS:000372535600001
PM 27340444
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Jin, GL
   Ma, M
   Yang, CY
   Zhen, L
   Feng, MK
AF Jin, Guilin
   Ma, Mi
   Yang, Chunyan
   Zhen, Luo
   Feng, Mingke
TI Salidroside suppresses the multiple oncogenic activates and immune
   escape of lung adenocarcinoma through the circ_0009624-mediated PD-L1
   pathway
SO THORACIC CANCER
LA English
DT Article
DE Circ_0009624; LUAD; PD-L1; salidroside
ID CANCER CELLS; PROLIFERATION; MIGRATION; RNA
AB Background: Lung adenocarcinoma (LUAD) is a fatal malignancy all over the world. Salidroside (SAL) is an active component extracted from Rhodiola rosea that has been reported to exert antitumor activity against several human cancers, containing lung adenocarcinoma (LUAD). The purpose of this study was to explore the effect and underlying mechanism of SAL in LUAD.Methods: Cell viability, proliferation, migration, and invasion were measured using cell counting kit-8 (CCK-8), 5-ethynyl-2'-deoxyuridine (EdU), and transwell assays. Effects of LUAD cells on the cytotoxicity, percentage, and death of CD8(+) cells were detected using lactate dehydrogenase (LDH) and flow cytometry assays. Programmed cell death ligand 1 (PD-L1) protein level was examined using western blot. Circ_0009624, enolase 1 (ENO1), and PD-L1 levels were determined using real-time quantitative polymerase chain reaction (RT-qPCR). The biological role of SAL on LUAD tumor growth was assessed using the xenograft tumor model in vivo.Results: SAL restrained LUAD cell proliferation, migration, invasion, and immune escape in vitro via modulating PD-L1. Circ_0009624 expression was increased in LUAD. Applying SAL repressed circ_0009624 and PD-L1 expression in LUAD cells. SAL treatment hindered suppressed various oncogenic activates and immune escape of LUAD cells by regulating the circ_0009624/PD-L1 pathway. SAL blocked LUAD xenograft growth in vivo.Conclusion: Applying SAL might constrain malignant phenotypes and immune escape of LUAD cells partially through the circ_0009624-mediated PD-L1 pathway, providing a novel insight for LUAD treatment.
C1 [Jin, Guilin; Ma, Mi; Yang, Chunyan; Zhen, Luo; Feng, Mingke] Univ Tibetan Med, Lhasa, Peoples R China.
   [Feng, Mingke] Univ Tibetan Med, 10 Dangre Middle Rd, Lhasa City, Peoples R China.
C3 Xizang University of Tibetan Medicine; Xizang University of Tibetan
   Medicine
RP Feng, MK (corresponding author), Univ Tibetan Med, 10 Dangre Middle Rd, Lhasa City, Peoples R China.
EM 15002684034@163.com
FU study on Anti-hypoxia and Preparation Process Optimization of Rhodiola
   Rosea Compound Tablets [2022ZYYGH08]
FX study on Anti-hypoxia and Preparation Process Optimization of Rhodiola
   Rosea Compound Tablets, Grant/Award Number: 2022ZYYGH08
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NR 49
TC 5
Z9 7
U1 0
U2 21
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1759-7706
EI 1759-7714
J9 THORAC CANCER
JI Thorac. Cancer
PD AUG
PY 2023
VL 14
IS 24
BP 2493
EP 2503
DI 10.1111/1759-7714.15034
EA JUL 2023
PG 11
WC Oncology; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Respiratory System
GA Q6GG4
UT WOS:001025771800001
PM 37423604
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, QQ
   Chen, Q
   Xiao, SG
   Wang, SH
   Ge, XG
   Wang, Q
   Zheng, LT
   Wei, QQ
   Du, W
   Shen, WB
   Wu, Y
   Song, JB
AF Li, Qingqing
   Chen, Qing
   Xiao, Shenggan
   Wang, Shuhan
   Ge, Xiaoguang
   Wang, Qian
   Zheng, Liting
   Wei, Qiaoqiao
   Du, Wei
   Shen, Wenbin
   Wu, Ying
   Song, Jibin
TI A Salidroside-Based Radiosensitizer Regulates the Nrf2/ROS Pathway for
   X-Ray Activated Synergistic Cancer Precise Therapy
SO ADVANCED MATERIALS
LA English
DT Article
DE activatable probe; in vivo bioimaging; NIR-II fluorescence;
   radiotherapy; self-assembly
AB The hypoxic microenvironment and radioresistance of tumor cells, as well as the delay in efficacy evaluation, significantly limit the effect of clinical radiotherapy. Therefore, developing effective radiosensitizers with monitoring of tumor response is of great significance for precise radiotherapy. Herein, a novel radiosensitizer (term as: SCuFs) is developed, consisting of traditional Chinese medicine (TCM) compounds salidroside, Cu2+, and hydroxyl radical (center dot OH) activated second near-infrared window fluorescence (NIR-II FL) molecules, which make the radiosensitization effect and boosted chemodynamic therapy (CDT) efficacy. The overexpressed glutathione in the tumor induces the SCuFs dissociation, allowing deep penetration of the drug to the whole tumor region. After X-ray irradiation, salidroside inhibits the Nuclear factor erythroid 2-like 2 (Nrf2)protein expression and blocks cells in the G2/M phase with the highest radiosensitivity, which amplifies the reactive oxygen species (ROS) generation to exacerbate DNA damage, thus achieving radiosensitization. Meanwhile, the upregulated ROS provides sufficient chemical fuel for Cu+-mediated CDT to produce more center dot OH. NIR-II FL imaging can monitor the center dot OH changes during the therapy process, confirming the radiosensitization effect and CDT process related to center dot OH. This study not only achieves effective radiosensitization and cascaded ROS-mediated CDT efficacy, but also provides a useful tool for monitoring therapeutic efficacy, showing great prospects for clinical application.
C1 [Li, Qingqing; Xiao, Shenggan; Wang, Shuhan; Ge, Xiaoguang; Zheng, Liting; Du, Wei] Fuzhou Univ, Coll Chem, Fujian Sci & Technol Innovat Lab Optoelect Informa, Fuzhou 350108, Peoples R China.
   [Chen, Qing; Wang, Qian; Wei, Qiaoqiao; Wu, Ying; Song, Jibin] Beijing Univ Chem Technol, Coll Chem, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China.
   [Shen, Wenbin] Hebei Med Univ, Hosp 4, Dept Radiotherapy, Shijiazhuang 050011, Peoples R China.
C3 Fuzhou University; Fujian Science & Technology Innovation Laboratory for
   Optoelectronic Information of China; Beijing University of Chemical
   Technology; Hebei Medical University
RP Song, JB (corresponding author), Beijing Univ Chem Technol, Coll Chem, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China.
EM jibin.song@buct.edu.cn
RI Song, Jibin/AAF-7947-2021; Wu, Ying/H-7639-2017
FU Fujian Science & Technology Innovation Laboratory for Optoelectronic
   Information of China; Beijing Outstanding Young Scientist Program
   [JWZQ20240101010]; National key research and development plan
   [2023YFB3810002]; Fundamental Research Funds for the Central
   Universities [buctrc202235]; National Natural Science Foundation of
   China [U21A20377, 82202239, U22A20348];  [2021ZZ126]
FX Q.L. and Q.C. contributed equally to this work. The authors appreciate
   the efforts and assistance of all the partners. This study was supported
   by the Beijing Outstanding Young Scientist Program (JWZQ20240101010)
   National key research and development plan (No. 2023YFB3810002) Fujian
   Science & Technology Innovation Laboratory for Optoelectronic
   Information of China (2021ZZ126), the Fundamental Research Funds for the
   Central Universities (buctrc202235), National Natural Science Foundation
   of China (Nos. U21A20377, 82202239, U22A20348).
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NR 60
TC 19
Z9 20
U1 29
U2 103
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 0935-9648
EI 1521-4095
J9 ADV MATER
JI Adv. Mater.
PD JUN
PY 2025
VL 37
IS 24
DI 10.1002/adma.202413226
EA APR 2025
PG 15
WC Chemistry, Multidisciplinary; Chemistry, Physical; Nanoscience &
   Nanotechnology; Materials Science, Multidisciplinary; Physics, Applied;
   Physics, Condensed Matter
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Materials Science;
   Physics
GA 3XE5J
UT WOS:001461597400001
PM 40195850
OA Bronze
DA 2026-05-27
ER

PT J
AU Wang, ZY
   Li, L
   Yan, HY
   Li, WL
   Pang, Y
   Yuan, Y
AF Wang, Ziyue
   Li, Lu
   Yan, Haiyang
   Li, Wenliang
   Pang, Yong
   Yuan, Yuan
TI Salidroside Ameliorates Furan-Induced Testicular Inflammation in
   Relation to the Gut-Testis Axis and Intestinal Apoptosis
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE furan; salidroside (SAL); testicular inflammation; gut microbiota;
   intestinal apoptosis
ID ENDOPLASMIC-RETICULUM STRESS; REGULATING OXIDATIVE STRESS; PROTECTIVE
   ROLE; LIVER-INJURY; MICE; BARRIER; EXPOSURE; ACTIVATION; TOXICITY;
   DAMAGE
AB Furan is a heat-induced food contaminant, and it causes damage to visceral organs, including the testis. To determine the mechanism of the damage to the testis, a mouse model treated with furan (8 mg/kg bw/day) and salidroside (SAL, 10/20/40 mg/kg bw/day) was established, and levels of testicular functional markers and changes of morphology were investigated in furan-induced mice treated with SAL. The change in related proteins and genes suggested that SAL restored the furan-mediated leaky tight junction and triggered the TLR4/MyD88/NF-kappa B pathway and NLRP3 inflammasome together with inflammation. To find out the gut-testis axis, microbiota PICRUSt analysis and correlation analysis were conducted to investigate the core microbiota and metabolites. The endoplasmic reticulum stress (ERS)-related key protein levels and the result of transmission electron microscopy suggested that SAL inhibited the furan-induced intestinal ERS. The result of TUNEL and levels of apoptosis-related proteins suggested that furan-induced intestinal apoptosis was alleviated by SAL. Collectively, SAL inhibited furan-induced ERS-mediated intestinal apoptosis through modulation of intestinal flora and metabolites, thus strengthening the gut barrier. It inhibited LPS from entering the circulatory system and suppressed the testicular TLR4/MyD88/NF-kappa B pathway and NLRP3 inflammasome, which alleviated testicular inflammation.
C1 [Wang, Ziyue; Li, Lu; Yan, Haiyang; Li, Wenliang; Pang, Yong; Yuan, Yuan] Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Peoples R China.
C3 Jilin University
RP Yuan, Y (corresponding author), Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Peoples R China.
EM yuan_yuan@jlu.edu.cn
RI Li, Wenliang/F-2907-2014
FU Jilin University [31972181, 2023CX137]; National Natural Science
   Foundation of China
FX The authors are thankful to the National Natural Science Foundation of
   China (No. 31972181) and Jilin University Ph.D. Interdisciplinary
   Research Funding Project (No. 2023CX137) for the fund supporting.
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NR 67
TC 16
Z9 17
U1 4
U2 71
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD NOV 9
PY 2023
VL 71
IS 46
BP 17968
EP 17987
DI 10.1021/acs.jafc.3c06587
PG 20
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA Y9PG1
UT WOS:001108501000001
PM 37943949
DA 2026-05-27
ER

PT J
AU Pan, Y
   He, YC
   Zhao, X
   Pan, Y
   Meng, XL
   Lv, ZY
   Hu, ZM
   Mou, XZ
   Cai, Y
AF Pan, Yi
   He, Yichen
   Zhao, Xin
   Pan, Yue
   Meng, Xuli
   Lv, Zhenye
   Hu, Zhiming
   Mou, Xiaozhou
   Cai, Yu
TI Engineered Red Blood Cell Membrane-Coating Salidroside/Indocyanine Green
   Nanovesicles for High-Efficiency Hypoxic Targeting Phototherapy of
   Triple-Negative Breast Cancer
SO ADVANCED HEALTHCARE MATERIALS
LA English
DT Article
DE engineered red blood cell membranes; hypoxic targeted drug delivery;
   photoacoustic imaging; phototherapy; triple-negative breast cancer
ID THERAPY; EXPRESSION
AB Triple-negative breast cancer (TNBC) presents special biological behavior and clinicopathological characteristics and leads to a worse prognosis than other types of breast cancer. The development of an effective therapeutic method is significant to improve the survival rate of TNBC cancer patients. In this work, an engineered red blood cell membrane (RBCm)-coating salidroside/indocyanine green nanovesicle (ARISP) is successfully prepared for hypoxic targeting phototherapy of TNBC. Salidroside in ARISP effectively ameliorates hypoxia-induced tumorigenesis by downregulating the expression of hypoxia-inducible factor 1 alpha (HIF-1 alpha), which increases the killing effect of reactive oxygen species on tumor cells during photodynamic therapy (PDT) using the photosensitizer indocyanine green. Besides, ARISP has an anti-LDLR modified RBCm-coating that extends its circulation time in the blood and escapes from immune surveillance and enhances hypoxia-targeted cellular uptake via the overexpressed LDLR receptor in hypoxic tumor sites. Moreover, guided by near-infrared fluorescence imaging and photoacoustic imaging, ARISP can eliminate tumors via high-efficiency phototherapy and inhibit lung and liver metastasis in TNBC models. Cytotoxicity assay of ARISP indicates the excellent biocompatibility with normal cells and tissues. This study provides fulfilling insights into the anticancer mechanism of reducing HIF-1 alpha for enhanced PDT and has a promising therapeutic potential for TNBC treatment.
C1 [Pan, Yi; He, Yichen; Pan, Yue] Zhejiang Univ Technol, Coll Pharm, Hangzhou 310014, Zhejiang, Peoples R China.
   [Pan, Yi; He, Yichen; Zhao, Xin; Mou, Xiaozhou; Cai, Yu] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Ctr Rehabil Med,Dept Rehabil Med, Canc Ctr,Peoples Hosp,Rehabil & Sports Med Res In, Hangzhou 310014, Zhejiang, Peoples R China.
   [Pan, Yi; He, Yichen; Zhao, Xin; Mou, Xiaozhou; Cai, Yu] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Clin Res Inst, Peoples Hosp, Hangzhou 310014, Zhejiang, Peoples R China.
   [Zhao, Xin] Hangzhou Med Coll, Coll Pharm, Hangzhou 310059, Zhejiang, Peoples R China.
   [Meng, Xuli; Lv, Zhenye] Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Canc Ctr, Dept Breast Surg,Peoples Hosp,Gen Surg, Hangzhou 310014, Zhejiang, Peoples R China.
   [Hu, Zhiming] Zhejiang Prov Tongde Hosp, Dept Hepatobiliary Pancreat Surg, Hangzhou 310012, Zhejiang, Peoples R China.
C3 Zhejiang University of Technology; Hangzhou Medical College; Zhejiang
   Provincial People's Hospital; Hangzhou Medical College; Zhejiang
   Provincial People's Hospital; Hangzhou Medical College; Hangzhou Medical
   College; Zhejiang Provincial People's Hospital; Tongde Hospital of
   Zhejiang Province
RP Mou, XZ; Cai, Y (corresponding author), Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Ctr Rehabil Med,Dept Rehabil Med, Canc Ctr,Peoples Hosp,Rehabil & Sports Med Res In, Hangzhou 310014, Zhejiang, Peoples R China.; Mou, XZ; Cai, Y (corresponding author), Hangzhou Med Coll, Zhejiang Prov Peoples Hosp, Clin Res Inst, Peoples Hosp, Hangzhou 310014, Zhejiang, Peoples R China.; Hu, ZM (corresponding author), Zhejiang Prov Tongde Hosp, Dept Hepatobiliary Pancreat Surg, Hangzhou 310012, Zhejiang, Peoples R China.
EM huzhiming@hmc.edu.cn; mouxz@zju.edu.cn; caiyu@hmc.edu.cn
RI ; pan, yi/OZL-4510-2025
OI Cai, Yu/0000-0001-8669-4418; Meng, XuLi/0000-0002-5555-0232; 
FU Natural Science Foundation of Zhejiang Province [LQ22F050010]; Excellent
   research start-up fund of Zhejiang Provincial People's Hospital
FX The work was supported by the Natural Science Foundation of Zhejiang
   Province (LQ22F050010), Excellent research start-up fund of Zhejiang
   Provincial People's Hospital.
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NR 50
TC 46
Z9 55
U1 3
U2 92
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 2192-2640
EI 2192-2659
J9 ADV HEALTHC MATER
JI Adv. Healthc. Mater.
PD SEP
PY 2022
VL 11
IS 17
AR 2200962
DI 10.1002/adhm.202200962
EA JUL 2022
PG 20
WC Engineering, Biomedical; Nanoscience & Nanotechnology; Materials
   Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering; Science & Technology - Other Topics; Materials Science
GA 4I6NP
UT WOS:000819551900001
PM 35735086
DA 2026-05-27
ER

PT J
AU Zhu, LP
   Wei, TT
   Gao, J
   Chang, XY
   He, H
   Luo, F
   Zhou, R
   Ma, CH
   Liu, Y
   Yan, TH
AF Zhu, Lingpeng
   Wei, Tingting
   Gao, Jin
   Chang, Xiayun
   He, He
   Luo, Fen
   Zhou, Rui
   Ma, Chunhua
   Liu, Yu
   Yan, Tianhua
TI The cardioprotective effect of salidroside against myocardial ischemia
   reperfusion injury in rats by inhibiting apoptosis and inflammation
SO APOPTOSIS
LA English
DT Article
DE Salidroside; I/R injury; Apoptosis Inflammation; TLR4/NF-kappa B
ID CARDIAC MYOCYTES; PATHWAY; CELLS
AB The main purpose of this study was to investigate effect of salidroside (Sal) on myocardial ischemia reperfusion injury in rats and the underlying mechanism. Myocardial ischemia reperfusion injury (MI/RI) model was treated with 30 min of left anterior descending (LAD) occlusion followed by 24 h of reperfusion. The male Sprague-Dawley rats were randomly divided into 7 groups: (1) Sham; (2) Sham + diltiazem (Dit, 10 mg/kg); (3) Sham + Sal (40 mg/kg); (4) I/R; (5) I/R + diltiazem (Dit, 10 mg/kg); (6) I/R + Sal (20 mg/kg); (7) I/R + Sal (40 mg/kg). Sal could ameliorate myocardial ischemia reperfusion injury as evidenced by Histopathological examination and triphenyl tetrazolium chloride (TTC) staining. Moreover, terminal deoxynucleotidyl transferase dUTP nickend labeling (TUNEL) assay demonstrated that Sal suppressed myocardial apoptosis, which may be related to up-regulation of Bcl-2/Bax ratio and inhibition of caspase-3, caspase-9 activation. Pretreatment with Sal affected serum biochemical parameters and cardiac dysfunction compared with I/R group. Sal also attenuated the pro-inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-1 beta and IL-6 in serum by inhibiting TLR4/NF-kappa B signaling pathway. Sal exerts strong favorable cardioprotective function on myocardial I/R injury which may relate to the down-regulation of the TLR4/NF-kappa B signaling pathway and the inhibition of cell apoptosis.
C1 [Zhu, Lingpeng; Liu, Yu] China Pharmaceut Univ, Coll Life Sci, Nanjing 210009, Jiangsu, Peoples R China.
   [Wei, Tingting; Gao, Jin; Chang, Xiayun; He, He; Luo, Fen; Zhou, Rui; Ma, Chunhua; Yan, Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University
RP Ma, CH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China.
EM machunhuabest@126.com; liuyuyaoda@163.com; yantianhuabest@126.com
RI zhou, rui/KZT-9353-2024; Ma, Chunhua/NFS-9026-2025; 卫, 婷婷/IUQ-4456-2023;
   he, he/JPL-3505-2023; Su, Tianyuan/Y-7054-2019
FU National Scientific & Technological major special Project "significant
   creation of new drugs'' [2011ZX09102-002-01]
FX This work was supported by the National Scientific & Technological major
   special Project "significant creation of new drugs''
   (2011ZX09102-002-01).
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NR 31
TC 124
Z9 142
U1 0
U2 40
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1360-8185
EI 1573-675X
J9 APOPTOSIS
JI Apoptosis
PD NOV
PY 2015
VL 20
IS 11
BP 1433
EP 1443
DI 10.1007/s10495-015-1174-5
PG 11
WC Biochemistry & Molecular Biology; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Cell Biology
GA CS1IK
UT WOS:000361817200003
PM 26385354
DA 2026-05-27
ER

PT J
AU Rabert, C
   Hödar, M
   Bravo, L
   Quiroz, A
   Urzua, A
AF Rabert, Claudia
   Hoedar, Martin
   Bravo, Leon
   Quiroz, Andres
   Urzua, Alejandro
TI A rapid preparative-TLC/GC-MS methodology for discriminating between two
   filmy ferns (Hymenophyllaceae) native from the temperate rain
   forest of Southern Chile based on their soluble carbohydrates
SO BOLETIN LATINOAMERICANO Y DEL CARIBE DE PLANTAS MEDICINALES Y AROMATICAS
LA English
DT Article
DE Hymenophyllum; Chilean native filmy ferns; carbohydrates; desiccation;
   GC-MS
ID PROTECTION MECHANISMS; DESICCATION TOLERANCE; CRATEROSTIGMA-WILMSII;
   RESURRECTION PLANTS; LIGHT; REHYDRATION
AB Filmy ferns are a conspicuous epiphytic component of the temperate rain forest of southern Chile and the more abundant genus is Hymenophyllum represented by 19 species, they are a primitive fern family sharing their limited water lost control (poikilohydricity) with lower non-vascular plants, such as bryophytes and lichens. Because, carbohydrate accumulation is a desiccation tolerance mechanism proposed for desiccation-tolerant vascularized plants, the aim of this investigation was to propose a methodology for soluble carbohydrate analysis in native ferns. Preparative-TLC showed to be a simple and rapid technique for separating Hymenophyllum sugars. GC-MS analysis allowed identifying glucitol (2.0%), sucrose (2.0%),. or alpha-melibiose (5.0%) and salidroside (4.4%) in H. cruentum carbohydrate profile from H. dentatum showed significant differences presenting only two sugars sucrose (1.4%) and. or beta-melibiose (3.2%). Furthermore, salidroside, an antioxidant compound, was identified only in H. cruentum. Our results suggest that H. cruentum, has higher preventive mechanisms than H. dentatum; that would allow delay the effects of desiccation (prevent a rapid dehydration) and thus survive to short periods of drought present in the study area. Due to the presence of salidroside in H. cruentum this species should be more resistant to oxidative stress that H. dentatum.
C1 [Rabert, Claudia; Bravo, Leon] Univ La Frontera, Dept Ciencias Agron & Recursos Nat, Fac Ciencias Agr & Forestales, Sci & Technol Bioresource Nucleus, Temuco, Chile.
   [Rabert, Claudia; Bravo, Leon] Univ La Frontera, Ctr Plant Soil Interact & Nat Resources Biotechno, Sci & Technol Bioresource Nucleus, Temuco, Chile.
   [Hoedar, Martin; Quiroz, Andres] Univ La Frontera, Dept Ciencias Quim & Recursos Nat, Temuco, Chile.
   [Urzua, Alejandro] Univ Santiago Chile, Dept Environm Sci, Fac Chem & Biol, Santiago, Chile.
C3 Universidad de La Frontera; Universidad de La Frontera; Universidad de
   La Frontera; Universidad de Santiago de Chile
RP Quiroz, A (corresponding author), Univ La Frontera, Dept Ciencias Quim & Recursos Nat, Temuco, Chile.
EM andres.quiroz@ufrontera.cl
RI ; Rabert, Claudia/MGB-5765-2025; Quiroz, Andres/I-2748-2018; Bravo,
   León/H-9251-2018
OI Urzua, Alejano/0000-0003-2638-0921; Rabert, Claudia/0000-0001-8179-9245;
   Bravo, León/0000-0003-4705-4842
FU FONDECYT [1120964]
FX Authors thanks FONDECYT project 1120964 for financial support and
   Katalapi Park for sample collection and logistic support; A. Urzua
   thanks to Proyectos Basales & Vicerrectoria de Investigacion, Desarrollo
   e Innovacion, Universidad de Santiago de Chile.
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NR 40
TC 2
Z9 6
U1 0
U2 13
PU UNIV SANTIAGO CHILE CASA
PI SANTIAGO
PA CENTRAL-OFICINA 110, AVENIDA LIBERTADOR BERNARDO O HIGGINS N 3 363,
   ESTACION CENTRAL, SANTIAGO, REGION METROPOLITANA 00000, CHILE
SN 0717-7917
J9 B LATINOAM CARIBE PL
JI Bol. Latinoam. Caribe Plantas M.
PD SEP
PY 2015
VL 14
IS 5
BP 364
EP 373
PG 10
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA CV8HI
UT WOS:000364522800003
DA 2026-05-27
ER

PT J
AU Ouyang, Q
   Zhou, H
   Yu, ZX
   Jiang, H
   Ji, CH
   Sun, YJ
   Zhou, F
   Xiang, SL
   Hu, X
AF Ouyang, Qi
   Zhou, Hao
   Yu, Zixuan
   Jiang, Hong
   Ji, Chenhao
   Sun, Yijia
   Zhou, Fang
   Xiang, Shuanglin
   Hu, Xiang
TI IKK/NF-κB Inactivation by Salidroside via Targeting TNF-α for the
   Treatment of LPS-Induced Colitis
SO CURRENT ISSUES IN MOLECULAR BIOLOGY
LA English
DT Article
DE salidroside; network pharmacology; TNF-alpha; IKK/NF-kappa B
AB Background: Tumor necrosis factor-alpha (TNF-alpha) serves as a central mediator of inflammation and represents key therapeutic target in inflammatory bowel disease (IBD). This study investigates the protective effects of salidroside (Sal) against inflammation and explores its underlying molecular mechanisms. Methods: We employed network pharmacology to identify potential targets of Sal. The anti-inflammatory effects of Sal were evaluated in LPS-Induced cellular models using NCM460 colonic epithelial cells and RAW264.7 macrophages, as well as in a murine model of acute colonic inflammation. Direct target engagement was confirmed through cellular thermal shift assay (CETSA) and co-immunoprecipitation (Co-IP). The mechanism was further elucidated via site-directed mutagenesis and analysis of the IKK/NF-kappa B signaling pathway. Results: Network pharmacology predicted TNF-alpha as a key target. Sal significantly attenuated LPS-Induced inflammation in vitro and ameliorated colitis symptoms in vivo. Notably, CETSA and Co-IP assays confirmed direct interaction between Sal and TNF-alpha. Mutagenesis studies identified Arg179, Lys188, and Tyr191 as critical residues for this binding. Mechanistically, Sal inhibited TNF-alpha-mediated activation of the IKK/NF-kappa B pathway and the subsequent production of pro-inflammatory cytokines. Conclusion: Our findings demonstrate that Sal alleviates inflammation by directly binding to TNF-alpha and suppressing the downstream NF-kappa B signaling cascade, thereby positioning it as a promising therapeutic candidate for TNF-alpha-driven inflammatory diseases.
C1 [Ouyang, Qi; Zhou, Hao; Yu, Zixuan; Jiang, Hong; Ji, Chenhao; Sun, Yijia; Hu, Xiang] Hunan Normal Univ, Coll Life Sci, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Changsha 410081, Peoples R China.
   [Zhou, Hao] Changsha Med Univ, Coll Clin Lab, Changsha 410219, Peoples R China.
   [Zhou, Fang; Xiang, Shuanglin] Hunan Normal Univ, Coll Life Sci, Engn Res Ctr Antibodies Expt Anim Hunan Prov, Changsha 410081, Peoples R China.
C3 Hunan Normal University; Changsha Medical University; Hunan Normal
   University
RP Hu, X (corresponding author), Hunan Normal Univ, Coll Life Sci, Natl & Local Joint Engn Lab Anim Peptide Drug Dev, Changsha 410081, Peoples R China.; Xiang, SL (corresponding author), Hunan Normal Univ, Coll Life Sci, Engn Res Ctr Antibodies Expt Anim Hunan Prov, Changsha 410081, Peoples R China.
EM oyq@hunnu.edu.cn; zhouhao1995@csmu.edu.cn; 202330233002@hunnu.edu.cn;
   202520143051@hunnu.edu.cn; 202330233030@hunnu.edu.cn;
   202530151171@hunnu.edu.cn; zhoufang@promab.cn; xshlin@hunnu.edu.cn;
   huxiang@hunnu.edu.cn
RI Hu, Xiang/OUH-7089-2025
OI hu, xiang/0000-0002-3751-430X
FU Key Research and Development Program of Hunan Province [2024DK2002];
   Hunan Provincial Key Laboratory of Regional Hereditary Birth Defects
   Prevention and Control [HPKL2023005]; Innovation and entrepreneurship
   fund for college students of Hunan Normal University [2024054]
FX This work was supported by the open research fund of Hunan Provincial
   Key Laboratory of Regional Hereditary Birth Defects Prevention and
   Control (HPKL2023005), Key Research and Development Program of Hunan
   Province (2024DK2002) and Innovation and entrepreneurship fund for
   college students of Hunan Normal University (2024054).
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NR 36
TC 2
Z9 2
U1 2
U2 2
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1467-3037
EI 1467-3045
J9 CURR ISSUES MOL BIOL
JI Curr. Issues Mol. Biol.
PD OCT 28
PY 2025
VL 47
IS 11
AR 896
DI 10.3390/cimb47110896
PG 16
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA F4724
UT WOS:001623575900001
PM 41296400
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhou, F
   Ju, J
   Fang, YJ
   Fan, XX
   Yan, SG
   Wang, Q
   Wei, PF
   Duan, FL
   Miao, F
   Hu, ZY
   Wang, MD
AF Zhou, Feng
   Ju, Jing
   Fang, Yongjun
   Fan, Xiaoxuan
   Yan, Shuguang
   Wang, Qiang
   Wei, Pengfang
   Duan, Fuliang
   Miao, Feng
   Hu, Zhenyuan
   Wang, Maode
TI Salidroside protected against MPP+-induced Parkinson's
   disease in PC12 cells by inhibiting inflammation, oxidative stress and
   cell apoptosis
SO BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
LA English
DT Article
DE apoptosis; inflammation; oxidative stress; Parkinson disease;
   salidroside
ID MODEL
AB The present study aimed to investigate the protective effects of salidroside (SAL) on 1-methyl-4-phenylpyridinium (MPP+)-induced PC12 cell model for Parkinson's disease. PC12 cells were pretreated with SAL in different concentrations and then exposed to MPP+. To evaluate the effects of SAL on cytotoxicity, the survival rate was tested by the 3-(4,5-dimethylthiazol-2-yl)-2,5-dimethyltetrazolium bromide (MTT) assay and the apoptosis was tested via flow cytometry and Western blot. Reactive oxygen species (ROS), glutathione (GSH), and malondialdehyde (MDA) were detected to analyze the effects of SAL on oxidative stress. The mRNA and protein levels of inflammatory factors TNF-alpha and IL-1 beta were also determined by real-time quantitative polymerase chain reaction and Western blot. Pretreatment with SAL effectively relieved the MPP+ cytotoxic effects and decreased the release of ROS production and inflammatory cytokines. SAL also inhibited apoptosis, suppressed MDA activity, and increased GSH levels in MPP+-treated PC12 cells. Moreover, the expression levels of caspase-9, caspase-3, and Bax were significantly decreased in the SAL treatment groups compared with the MPP+ group, whereas Bcl-2 expression was significantly increased in the SAL treatment groups. In summary, the overall results suggested that SAL have neuroprotective effects on the MPP+-induced PC12 cell model by inhibiting inflammation, oxidative stress, and cell apoptosis. SAL may be a potential active product to protect against Parkinson's disease.
C1 [Zhou, Feng; Fang, Yongjun; Fan, Xiaoxuan; Yan, Shuguang; Wei, Pengfang; Hu, Zhenyuan] Shaanxi Univ Chinese Med, Affiliated Hosp, Dept Neurosurg, Xianyang, Peoples R China.
   [Zhou, Feng; Wang, Maode] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Neurosurg, Xian 710061, Shaanxi, Peoples R China.
   [Ju, Jing] Xianyang IRICO Hosp, Operat Room, Xianyang, Peoples R China.
   [Wang, Qiang] Shaanxi Univ Chinese Med, Combinat Acupuncture & Med Innovat Res Ctr, Xianyang, Peoples R China.
   [Duan, Fuliang] Shaanxi Univ Chinese Med, Dept Chinese & Western Med, Xianyang, Peoples R China.
   [Miao, Feng] Shaanxi Univ Chinese Med, Affiliated Hosp, Dept Cerebropathy, Xianyang, Peoples R China.
C3 Shaanxi University of Chinese Medicine; Xi'an Jiaotong University;
   Shaanxi University of Chinese Medicine; Shaanxi University of Chinese
   Medicine; Shaanxi University of Chinese Medicine
RP Wang, MD (corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Neurosurg, Xian 710061, Shaanxi, Peoples R China.
EM maodewang@163.com
RI Zhou, Feng/E-6948-2019
OI Zhou, Feng/0000-0003-2252-7981
FU National Science Foundation of China [81674086]
FX This study was sponsored by National Science Foundation of China
   (81674086). The authors declare that they have no competing interests.
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NR 24
TC 32
Z9 39
U1 0
U2 27
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0885-4513
EI 1470-8744
J9 BIOTECHNOL APPL BIOC
JI Biotechnol. Appl. Biochem.
PD MAR-APR
PY 2019
VL 66
IS 2
BP 247
EP 253
DI 10.1002/bab.1719
PG 7
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA HW0OT
UT WOS:000466381400013
PM 30548933
DA 2026-05-27
ER

PT J
AU Feng, T
   Wang, LB
   Zhou, N
   Liu, C
   Cui, JH
   Wu, RX
   Jing, J
   Zhang, SY
   Chen, H
   Wang, SW
AF Feng, Tian
   Wang, Libin
   Zhou, Nan
   Liu, Chang
   Cui, Jiahui
   Wu, Rangxin
   Jing, Juan
   Zhang, Shengyong
   Chen, Hui
   Wang, Siwang
TI Salidroside, a scavenger of ROS, enhances the radioprotective effect of
   Ex-RAD® via a p53-dependent apoptotic pathway
SO ONCOLOGY REPORTS
LA English
DT Article
DE salidroside; Ex-RAD; radioprotection; ROS; apoptosis; DNA repair
ID DNA-DAMAGE; OXIDATIVE STRESS; IN-VITRO; RADIATION; BCL-2; MITOCHONDRIA;
   MECHANISMS; AMIFOSTINE; MELATONIN; FAMILY
AB Salidroside (Sal), the predominant component of a Chinese medicinal herb, Rhodiola rosea L., has become an attractive bioagent due to its significant anti-radiation, antioxidant and immune adjustment effects. We explored the radioprotective effect of Sal to ascertain whether it could enhance the anti-radiation effect of ON 01210. Na (Ex-RAD (R)) in vivo and in vitro, and elucidate its underlying mechanism. Our data demonstrated that Sal inhibited radiation-induced apoptosis, scavenged reactive oxygen species (ROS), and decreased the DNA damage of human umbilical vein endothelial cells (HUVECs). Sal downregulated the expression of Bax and p53 and increased the ratio of Bcl-2/Bax, which indicated that Sal inhibited the radiation-induced apoptosis through p53-dependent pathways. The radioprotection of the Sal pretreatment was also evidenced by an increasing survival rate of the mice, maintaining antioxidant enzyme levels in the liver, and accelerating hematopoietic recovery. The results suggest that Sal exhibits an excellent radioprotective effect with powerful antioxidant activity in vitro and in vivo. Sal enhanced the radioprotective effect of Ex-RAD by improving the antioxidant effect, the scavenging of ROS, by accelerating hematopoietic recovery and DNA repair as well as by regulating apoptotic and repair signaling pathways. Combined modality treatments were more effective than single-agent treatments, demonstrating the value of multiple-agent radioprotectants.
C1 [Feng, Tian; Wang, Libin; Zhou, Nan; Liu, Chang; Cui, Jiahui; Wu, Rangxin; Jing, Juan; Zhang, Shengyong; Chen, Hui] Fourth Mil Med Univ, Dept Med Chem, Sch Pharm, 169 Changlexi St, Xian 710032, Shaanxi, Peoples R China.
   [Feng, Tian; Wang, Siwang] Fourth Mil Med Univ, Inst Mat Med, Sch Pharm, 169 Changlexi St, Xian 710032, Shaanxi, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Chen, H (corresponding author), Fourth Mil Med Univ, Dept Med Chem, Sch Pharm, 169 Changlexi St, Xian 710032, Shaanxi, Peoples R China.; Wang, SW (corresponding author), Fourth Mil Med Univ, Inst Mat Med, Sch Pharm, 169 Changlexi St, Xian 710032, Shaanxi, Peoples R China.
EM cchenhui@fmmu.edu.cn; wangsiw@fmmu.edu.cn
OI Wang, Siwang/0000-0003-1888-4716
FU National Natural Science Foundation of China [81573343, 21503272]; Major
   Science and Technology Projects in Shanxi Province (Xianyang China)
   [2015SF2-08-01, 2017ZDJC-05]
FX We thank the National Natural Science Foundation of China (nos. 81573343
   and 21503272) and the Major Science and Technology Projects in Shanxi
   Province (Xianyang China) (2015SF2-08-01 and 2017ZDJC-05).
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NR 43
TC 19
Z9 21
U1 0
U2 39
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1021-335X
EI 1791-2431
J9 ONCOL REP
JI Oncol. Rep.
PD NOV
PY 2017
VL 38
IS 5
BP 3094
EP 3102
DI 10.3892/or.2017.5940
PG 9
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA FL2CG
UT WOS:000414021300057
PM 28901519
OA Bronze
DA 2026-05-27
ER

PT J
AU Zhao, HB
   Qi, SN
   Dong, JZ
   Ha, XQ
   Li, XY
   Zhang, QW
   Yang, YS
   Bai, J
   Zhao, L
AF Zhao, Hong-Bin
   Qi, She-Ning
   Dong, Ju-Zi
   Ha, Xiao-Qin
   Li, Xiao-Yun
   Zhang, Quan-Wei
   Yang, Yin-Shu
   Bai, Jie
   Zhao, Ling
TI Salidroside induces neuronal differentiation of mouse mesenchymal stem
   cells through Notch and BMP signaling pathways
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article
DE Salidroside; Mesenchymal stem cells; Differentiation; Notch signaling
   pathway; Bone morphogenetic proteins (BMP); signaling pathway
ID NEURAL DIFFERENTIATION; TRANSLATION; APOPTOSIS; CANCER
AB Salidroside (p-hydroxyphenethyl-beta-D-glucoside, SAL), a phenylpropanoid glycoside isolated from a popular traditional Chinese medicinal plant Rhodiola rosea L., possesses multiple pharmacological actions. Previous study showed that SAL could induce rat mesenchymal stem cells (MSCs) to differentiate into dopaminergic neurons and induce mouse MSCs D1 to differentiate into neuronal cells. However, the mechanisms of SAL-induced neuronal differentiation of MSCs still need investigation. In this study, we observed the effects of SAL on neuronal differentiation of D1 cells and the possible involvement of Notch and BMP signaling pathways. SAL inhibited the proliferation, induced neuronal phenotypes, and upregulated the expressions of neuronal-specific marker molecules, such as neuronal enolase 2 (Eno2/NSE), microtubule-associated protein 2 (MAP2), and beta 3 class III tubulin (Tubb3/beta-tubulin III) in D1 cells. SAL not only downregulated the expressions of Notch1 and hairy enhancer of split I (Drosophila) (Hes1) but also upregulated the expression of Smad1/5/8 and its phosphorylation (p-Smad 1/5/8). The neuronal differentiation effects of SAL on D1 cells were promoted by a Notch signaling antagonist, DAFT, but attenuated by a BMP signaling pathway antagonist, Noggin. Our findings suggest that SAL might be promising in inducing neuronal differentiation of mouse MSCs mediated by both Notch signaling pathway and BMP signaling pathway. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Zhao, Hong-Bin; Dong, Ju-Zi; Ha, Xiao-Qin; Li, Xiao-Yun; Zhang, Quan-Wei; Yang, Yin-Shu; Bai, Jie; Zhao, Ling] Gen Hosp Lanzhou Mil Command PLA, Inst Orthoped, Key Lab Stem Cells & Gene Med Gansu Prov, Lanzhou 730050, Gansu, Peoples R China.
   [Qi, She-Ning] Lanzhou Univ, Sch Basic Med, Dept Histol & Embryol, Key Lab Preclin Study New Drugs Gansu Prov, Lanzhou 730000, Gansu, Peoples R China.
C3 Lanzhou University
RP Zhao, HB (corresponding author), Gen Hosp Lanzhou Mil Command PLA, Inst Orthoped, Key Lab Stem Cells & Gene Med Gansu Prov, Lanzhou 730050, Gansu, Peoples R China.
EM zhao6703@aliyun.com; qishn@lzu.edu.cn
RI zhao, ling/AAC-9806-2020
FU National Natural Science Foundation of China [81073156]; Natural Science
   Foundation of Gansu Province, China [0710RJZA067]
FX This study was supported by the National Natural Science Foundation of
   China (No. 81073156) and the Natural Science Foundation of Gansu
   Province, China (No. 0710RJZA067).
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NR 35
TC 25
Z9 31
U1 0
U2 31
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD SEP
PY 2014
VL 71
BP 60
EP 67
DI 10.1016/j.fct.2014.05.031
PG 8
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Toxicology
GA AO6MR
UT WOS:000341466700008
PM 24929042
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Zhou, YX
   Wang, JY
   Zhao, Y
   Zhao, Y
   Yang, JY
   Wang, K
   Liu, X
   Qu, WJ
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   Gu, XL
AF Zhou, Yaxiong
   Wang, Juyu
   Zhao, Yu
   Zhao, Yang
   Yang, Jieyan
   Wang, Kuan
   Liu, Xiang
   Qu, Weijie
   Zhang, Limei
   Gu, Xiaolong
TI Salidroside Inhibits α-Amanitin-Induced AML-12 Cell Apoptosis via the
   Regulation of PINK1/Parkin-Mediated Mitophagy and Mitochondrial Function
SO CHEMICAL RESEARCH IN TOXICOLOGY
LA English
DT Article
AB Poisoning caused by the mushroom Amanita phalloides, due to the toxin alpha-amanitin, accounts for approximately 90% of food poisoning deaths in China with no specific antidotes. To investigate the role of salidroside (Sal) in alpha-amanitin (alpha-AMA)-induced mitophagy, mouse liver cells AML-12 were exposed to alpha-AMA in the presence of Sal or not. Intracellular reactive oxygen species (ROS) levels were measured using a ROS detection kit, mitochondrial activity was evaluated using a mitochondrial red fluorescent probe kit or JC-1 dye, and protein expression levels of PINK1, Parkin, LC3 II, P62, Bax, Bcl-2, Caspase 3, Cleaved-Caspase 3, PARP I, and Cleaved-PARP I were detected through Western blot. Results demonstrated that alpha-AMA led to increased intracellular ROS levels, cell apoptosis, and decreased mitochondrial membrane potential. Notably, expression levels of mitophagy-related proteins PINK1, Parkin, and LC3 increased significantly while the P62 protein expression decreased remarkably. Furthermore, Sal reversed the alpha-AMA-induced decrease in cell viability and mitochondrial membrane potential and increase in intracellular ROS level. In addition, Sal promoted expression levels of PINK1, Parkin, and LC3 II while suppressing the Bax/Bcl-2 ratio, Cleaved-Caspase 3, and Cleaved-PARP I as well as P62. The results above proved that salidroside alleviates alpha-AMA-induced mouse liver cells damage via promoting PINK1/Parkin-mediated mitophagy and reducing cell apoptosis.
C1 [Zhou, Yaxiong; Wang, Juyu; Zhao, Yu; Zhao, Yang; Yang, Jieyan; Wang, Kuan; Liu, Xiang; Qu, Weijie; Zhang, Limei; Gu, Xiaolong] Yunnan Agr Univ, Coll Vet Med, Dept Clin Vet Med, Kunming 650051, Peoples R China.
C3 Yunnan Agricultural University
RP Zhang, LM; Gu, XL (corresponding author), Yunnan Agr Univ, Coll Vet Med, Dept Clin Vet Med, Kunming 650051, Peoples R China.
EM 20073175@163.com; xuewu24588@126.com
RI ; Zhang, Limei/POU-2674-2026
OI Xiaolong, Gu/0000-0001-7111-2681; 
FU National Natural Science Foundation of China [31902335]; National
   Natural Science Foundation of China [202301BD070001-017]; Yunnan
   Revitalization Talent Support Program in Yunnan Province, Yunnan
   Province Agricultural Joint Key Project [202304BI090007]; Rural
   Vitalization Science and Technology Project-Gejiu Cattle Industry
   Science and Technology Mission in Yunnan Province
FX This work was supported by the National Natural Science Foundation of
   China (31902335), Yunnan Revitalization Talent Support Program in Yunnan
   Province, Yunnan Province Agricultural Joint Key Project
   (202301BD070001-017), and Rural Vitalization Science and Technology
   Project-Gejiu Cattle Industry Science and Technology Mission in Yunnan
   Province (202304BI090007).
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NR 21
TC 7
Z9 8
U1 1
U2 12
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0893-228X
EI 1520-5010
J9 CHEM RES TOXICOL
JI Chem. Res. Toxicol.
PD JUN 7
PY 2024
VL 37
IS 6
BP 1053
EP 1061
DI 10.1021/acs.chemrestox.4c00139
EA JUN 2024
PG 9
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Chemistry; Toxicology
GA UN2Q4
UT WOS:001242693300001
PM 38847154
DA 2026-05-27
ER

PT J
AU Shu, XM
   Hu, Y
   Fang, X
   Wang, J
   Qin, XY
   Lan, RF
AF Shu, Xing-Mei
   Hu, Yang
   Fang, Xin
   Wang, Jing
   Qin, Xiao-Yan
   Lan, Rongfeng
TI Salidroside alleviates cadmium-induced toxicity in mice by restoring the
   notch/HES-1 and RIP1-driven inflammatory signaling axis
SO INFLAMMATION RESEARCH
LA English
DT Article
DE Cd; HES-1; GL261; RIP1; Salidroside
ID RHODIOLA-ROSEA L.; APOPTOSIS; DISEASE; BDNF; FGF2
AB Objective Salidroside (SAL) is a marker glycoside of Rhodiola rosea with significant antioxidant, anti-inflammatory, and other health benefits. In this study, we determined its neuroprotective effects against Cd-induced toxicity in cultured cells and mice. Materials and methods GL261 cell and Cd-intoxicated mouse model were used. ICP-MS and MWM were performed to measure Cd content and Cd-induced cognitive impairment in mice, respectively. Results SAL attenuated Cd toxicity in GL261 cells as well as protected mice from substantial organic damage and cognitive deficits. SAL treatment alleviated Cd-induced oxidative stress, glial cell activation, and elevation of pro-inflammatory factors including TNF-alpha, IL-1 beta, and IL-6. Cd-induced cognitive deficits observed in the Morris water maze in mice were rescued by SAL. At the mechanistic level, SAL maintained the activity of antioxidant enzymes such as SOD and GSH-Px in the serum and brain, and scavenged the peroxidation product MDA, thereby restoring redox homeostasis in vivo, attenuating neuronal damage, and ultimately antagonized Cd-induced toxicity. Furthermore, Cd activated the RIP1-driven inflammatory signaling pathway and Notch/HES-1 signaling axis in the brain, leading to inflammation and neuronal loss, which could be attenuated by SAL. Conclusion SAL is a natural product with good anti-Cd effects, indicating that Rhodiola rosea is promising plant that is worthy of cultivation for health and economic benefits.
C1 [Shu, Xing-Mei; Hu, Yang; Fang, Xin; Wang, Jing; Qin, Xiao-Yan] Minzu Univ China, Key Lab Ecol & Environm Minor Areas Natl Ethn Aff, Ctr Translat Neurosci, Coll Life & Environm Sci, Beijing 100081, Peoples R China.
   [Lan, Rongfeng] Shenzhen Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol & Med Genet, Shenzhen 518060, Peoples R China.
C3 Shenzhen University
RP Qin, XY (corresponding author), Minzu Univ China, Key Lab Ecol & Environm Minor Areas Natl Ethn Aff, Ctr Translat Neurosci, Coll Life & Environm Sci, Beijing 100081, Peoples R China.; Lan, RF (corresponding author), Shenzhen Univ, Hlth Sci Ctr, Sch Basic Med Sci, Dept Cell Biol & Med Genet, Shenzhen 518060, Peoples R China.
EM bjqinxiaoyan@muc.edu.cn; lan@szu.edu.cn
RI HU, Yang/JDM-9952-2023
OI HU, Yang/0000-0001-8539-7534; Lan, Rongfeng/0000-0003-2124-7232
FU National Natural Science Foundation of China [81873088, 21778038];
   Top-Ranking Project of Shenzhen University [860000210]
FX We acknowledge financial support from the National Natural Science
   Foundation of China (81873088, 21778038) and the Top-Ranking Project of
   Shenzhen University (860000210).
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NR 34
TC 11
Z9 11
U1 2
U2 10
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 1023-3830
EI 1420-908X
J9 INFLAMM RES
JI Inflamm. Res.
PD JUN
PY 2022
VL 71
IS 5-6
BP 615
EP 626
DI 10.1007/s00011-022-01580-4
EA MAY 2022
PG 12
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA 1V1BB
UT WOS:000797273500001
PM 35583558
DA 2026-05-27
ER

PT J
AU Morimura, KI
   Gatayama, A
   Tsukimata, R
   Matsunami, K
   Otsuka, H
   Hirata, E
   Shinzato, T
   Aramoto, M
   Takeda, Y
AF Morimura, Ken-Ichi
   Gatayama, Asuka
   Tsukimata, Reiki
   Matsunami, Katsuyoshi
   Otsuka, Hideaki
   Hirata, Eiji
   Shinzato, Takakazu
   Aramoto, Mitsunori
   Takeda, Yoshio
TI 5-O-glucosyldihydroflavones from the leaves of Helicia
   cochinchinensis
SO PHYTOCHEMISTRY
LA English
DT Article
DE Helicia cochinchinensis; proteaceae; flavanonol glucoside; heliciosides
   A and B; helicidol; alloside
ID GLYCOSIDES; CONSTITUENTS; RHAMNOSIDE
AB From the leaves of Helicia cochinchinensis, collected on Okinawa Island, seven phenolic glucosides and two terpenic glucosides were isolated. Five of the phenolic glucosides were previously known, being identified with p-coumaric and ferulic acids glucosyl esters, rhodioloside, helicidiol, and naringenin 5-O-beta-D-glueopyranoside. The structures of two other phenolic glucosides, named heliciosides A and B, were elucidated to be 5-O-beta-D-glucosides of 3-hydroxyflavanone, namely aromadendrin and taxifolin, by means of spectroscopic analyses. The two terpenic glucosides were identified with ampelopsisionoside and icariside C-1. (c) 2006 Elsevier Ltd. All rights reserved.
C1 Hiroshima Univ, Grad Sch Biomed Sci, Dept Pharmacognosy, Minami Ku, Hiroshima 7348553, Japan.
   Univ Ryukyus, Fac Agr, Okinawa 9030129, Japan.
   Univ Ryukyus, Trop Biosphere Res Ctr, Iriomot Stn, Okinawa 9071541, Japan.
   Univ Tokushima, Fac Integrated Arts & Sci, Tokushima 7708502, Japan.
C3 Hiroshima University; University of the Ryukyus; University of the
   Ryukyus; Tokushima University
RP Otsuka, H (corresponding author), Hiroshima Univ, Grad Sch Biomed Sci, Dept Pharmacognosy, Minami Ku, 1-2-3 Kasumi, Hiroshima 7348553, Japan.
EM hotsuka@hiroshima-u.ac.jp
RI Matsunami, Katsuyoshi/AHC-4234-2022
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NR 15
TC 22
Z9 31
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0031-9422
J9 PHYTOCHEMISTRY
JI Phytochemistry
PD DEC
PY 2006
VL 67
IS 24
BP 2681
EP 2685
DI 10.1016/j.phytochem.2006.08.001
PG 5
WC Biochemistry & Molecular Biology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Plant Sciences
GA 118PS
UT WOS:000242954800012
PM 16973192
DA 2026-05-27
ER

PT J
AU Liu, KX
   Zhang, LY
   Xu, XL
   Xiao, LL
   Wen, JH
   Zhang, HB
   Zhao, SX
   Qiao, DL
   Bai, JH
   Liu, Y
AF Liu, Kexiong
   Zhang, Luyao
   Xu, Xiaoling
   Xiao, Linli
   Wen, Junhui
   Zhang, Hanbing
   Zhao, Shuxin
   Qiao, Dongliang
   Bai, Jiahua
   Liu, Yan
TI The Antioxidant Salidroside Ameliorates the Quality of Postovulatory
   Aged Oocyte and Embryo Development in Mice
SO ANTIOXIDANTS
LA English
DT Article
DE salidroside; postovulatory aging; oocyte; autophagy; oxidative stress;
   MAPK
ID IN-VITRO MATURATION; OXIDATIVE STRESS; MOLECULAR-CHANGES; CELL
   APOPTOSIS; MOUSE OOCYTES; CUMULUS CELLS; FERTILIZATION; MITOCHONDRIA;
   AUTOPHAGY; PROTECTS
AB Postovulatory aging is known to impair the oocyte quality and embryo development due to oxidative stress in many different animal models, which reduces the success rate or pregnancy rate in human assisted reproductive technology (ART) and livestock timed artificial insemination (TAI), respectively. Salidroside (SAL), a phenylpropanoid glycoside, has been shown to exert antioxidant and antitumor effects. This study aimed to investigate whether SAL supplementation could delay the postovulatory oocyte aging process by alleviating oxidative stress. Here, we show that SAL supplementation decreases the malformation rate and recovers mitochondrial dysfunction including mitochondrial distribution, mitochondrial membrane potential (Delta psi) and ATP content in aged oocytes. In addition, SAL treatment alleviates postovulatory aging-caused oxidative stress such as higher reactive oxygen species (ROS) level, lower glutathione (GSH) content and a reduced expression of antioxidant-related genes. Moreover, the cytoplasmic calcium ([Ca2+]c) and mitochondrial calcium ([Ca2+]mt) of SAL-treated oocytes return to normal levels. Notably, SAL suppresses the aging-induced DNA damage, early apoptosis and improves spindle assembly in aged oocytes, ultimately elevating the embryo developmental rates and embryo quality. Finally, the RNA-seq and confirmatory experience showed that SAL promotes protective autophagy in aged oocytes by activating the MAPK pathway. Taken together, our research suggests that supplementing SAL is an effective and feasible method for preventing postovulatory aging and preserving the oocyte quality, which potentially contributes to improving the successful rate of ART or TAI.
C1 [Liu, Kexiong; Xu, Xiaoling; Xiao, Linli; Wen, Junhui; Zhang, Hanbing; Zhao, Shuxin; Bai, Jiahua; Liu, Yan] Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing 100097, Peoples R China.
   [Zhang, Luyao] Chinese Acad Sci, Northwest Inst Plateau Biol, Key Lab Adaptat & Evolut Plateau Biota, Xining 810001, Peoples R China.
   [Qiao, Dongliang] Minist Agr & Rural Affairs, Dev Ctr Sci & Technol, Beijing 100176, Peoples R China.
C3 Beijing Academy of Agriculture & Forestry Sciences (BAAFS); Chinese
   Academy of Sciences
RP Bai, JH; Liu, Y (corresponding author), Beijing Acad Agr & Forestry Sci, Inst Anim Husb & Vet Med, Beijing 100097, Peoples R China.
EM liukexiong2023@163.com; zhangluyao@nwipb.cas.cn; bai_jiahua@126.com;
   liuyanxms@163.com
RI 小鹿, 斑比/GYJ-7316-2022; LIU, kexiong/GRR-9180-2022; Zhang,
   Hanbing/AFF-2769-2022
FU National Key Research and Development Program, China [2022YFD1300302];
   Scientific & Technological Innovation Ability Construction Project of
   the Beijing Academy of Agriculture and Forestry Sciences [KJCX20230218];
   Beijing Innovation Consortium of Livestock Research System [BAIC05-2024]
FX This work was supported by the National Key Research and Development
   Program, China[grant number 2022YFD1300302]; the Scientific &
   Technological Innovation Ability Construction Project of the Beijing
   Academy of Agriculture and Forestry Sciences [grant number
   KJCX20230218]and the Beijing Innovation Consortium of Livestock Research
   System [grant number BAIC05-2024].
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NR 63
TC 15
Z9 17
U1 1
U2 14
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2076-3921
J9 ANTIOXIDANTS-BASEL
JI Antioxidants
PD FEB
PY 2024
VL 13
IS 2
AR 248
DI 10.3390/antiox13020248
PG 19
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science
   & Technology
GA IS2B2
UT WOS:001168244300001
PM 38397846
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, XY
   Fang, CJ
AF Chen, Xiaoyan
   Fang, Chunjuan
TI Effect of salidroside on bone marrow haematopoiesis in a mouse model of
   myelosuppressed anaemia
SO JOURNAL OF RADIATION RESEARCH
LA English
DT Article
DE salidroside; bone marrow haematopoiesis; myelosuppressed anemia;
   hematopoietic progenitors
ID INJURY; CELLS; MICE
AB This study was designed to investigate the effect of salidroside (SAL) on bone marrow haematopoiesis in a mouse model of myelosuppressed anemia. After the mouse model was established by Co-60 gamma irradiation and cyclophosphamide, pancytopenia and a sharp reduction in bone marrow stromal cells and bone marrow haematopoietic stem cells (lineage(-)Scal(+)c-kit(+)) were observed. This was greatly alleviated by SAL (25 mg/kg, 50 mg/kg, 100 mg/ kg) in a dose-dependent manner (50% effective dose value of 35.7 mg/kg and 61.2 mg/kg, respectively), followed by a distinct increment in anti-apoptotic protein Bcl-2. For cell culture in vitro, treatment with SAL resulted in a significant recovery of burst-forming unit-erythroids, and colony-forming unit-granulocyte macrophages on Day 7, and colony-forming unit-erythroids on Day 3, dose-dependently, but not of colony-forming unit-megakaryocyte macrophages. Inoculation of bone marrow cells derived from SAL-administrated donor mice resulted in a 60% survival of recipient mice at the high dose of 100 mg/kg SAL at 2 months after surgery. SAL appeared to be able to stimulate the restoration of bone marrow haemopoietic regulation in myelosuppressed anemia. Based on the downregulation of Fas ligand associated with the expression of Caspase-3 at the protein level, it was suggested that SAL might have an anti-apoptotic effect on bone marrow cells in the Fas-apoptotic pathway of Fas/FasL-caspase-3.
C1 [Chen, Xiaoyan; Fang, Chunjuan] Jiangxi Univ Technol, Sch Nursing, Campus Ctr Univ, Nanchang 330098, Jiangxi, Peoples R China.
C3 Jiangxi University of Technology
RP Chen, XY (corresponding author), Jiangxi Univ Technol, Sch Nursing, Campus Ctr Univ, Nanchang 330098, Jiangxi, Peoples R China.
EM chenxyan5@126.com
FU Jiangxi Provincial Science Foundation for Young Scholars
   [20171BAB215082]; Natural Science Project of Jiangxi Science and
   Technology College [16ZRYB02, 16ZRYB03]
FX This work was supported by Jiangxi Provincial Science Foundation for
   Young Scholars (Project No.: 20171BAB215082); Natural Science Project of
   Jiangxi Science and Technology College (Project No.: 16ZRYB02 &
   16ZRYB03).
CR Alotaibi NAS, 2016, PLOS ONE, V11, DOI 10.1371/journal.pone.0162748
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NR 17
TC 6
Z9 8
U1 0
U2 11
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0449-3060
EI 1349-9157
J9 J RADIAT RES
JI J. Radiat. Res.
PD MAR
PY 2019
VL 60
IS 2
BP 197
EP 203
DI 10.1093/jrr/rry093
PG 7
WC Biology; Oncology; Radiology, Nuclear Medicine & Medical Imaging
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics; Oncology; Radiology, Nuclear
   Medicine & Medical Imaging
GA HQ8ZW
UT WOS:000462716900005
PM 30462331
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Sun, LW
   Isaak, CK
   Zhou, YL
   Petkau, JC
   Karmin, O
   Liu, YJ
   Siow, YL
AF Sun, Liwei
   Isaak, Cara K.
   Zhou, Yaling
   Petkau, Jay C.
   Karmin, O.
   Liu, Yujun
   Siow, Yaw L.
TI Salidroside and tyrosol from Rhodiola protect H9c2 cells from
   ischemia/reperfusion-induced apoptosis
SO LIFE SCIENCES
LA English
DT Article
DE Rhodiola; Salidroside; Tyrosol; Ischemia-reperfusion; JNK signaling
   pathway; Apoptosis
ID TOTAL PHENOLIC CONTENT; ISCHEMIA-REPERFUSION INJURY; MAGNESIUM
   TANSHINOATE-B; ANTIOXIDANT PROPERTIES; ENDOTHELIAL-CELLS; SIGNALING
   PATHWAY; CARDIAC MYOCYTES; OXIDATIVE STRESS; ACTIVATION; KINASE
AB Aims: Heart disease is the leading cause of death worldwide. Ischemia-reperfusion injury can lead to apoptotic death of heart cells and subsequently heart failure. Rhodiola is an herbal medicine with two main bioactive compounds salidroside (SAL) and tyrosol (TYR). This study aimed to investigate whether these two compounds can prevent ischemia/reperfusion-induced apoptosis in H9c2 cells.
   Main methods: Assays for total phenolics assay and Oxygen Radical Absorbance Capacity showed high antioxidant capacity of SAL and TYR. H9c2 cells were subjected to simulated ischemia/reperfusion (IR) in the presence and absence of SAL and/or TYR, and nuclei condensation, caspase-3 activity, cytochrome c release and JNK phosphorylation were determined.
   Key findings: In H9c2 cells, IR can lead to a 5-fold increase in p-JNK level. Apoptotic nuclei condensation, caspase-3 activity and cytochrome c release were markedly elevated, indicating the occurrence of apoptosis. SAL and TYR caused a dose-dependent inhibition of nuclear condensation. Furthermore, SAL and TYR, separately and in combination, significantly reduced caspase-3 activity, cytochrome c release and JNK activation. The anti-apoptotic effect of the combination was markedly higher than that of SAL or TYR alone.
   Significance: The inhibition of the JNK signaling pathway is the key mechanism for the cytoprotective effect of SAL and TYR in IR-induced apoptosis. Crown Copyright (C) 2012 Published by Elsevier Inc. All rights reserved.
C1 [Siow, Yaw L.] Agr & Agri Food Canada, St Boniface Hosp, Res Ctr, Canadian Ctr Agri Food Res Hlth & Med, Winnipeg, MB R2H 2A6, Canada.
   [Sun, Liwei; Liu, Yujun] Beijing Forestry Univ, Coll Biol Sci & Biotechnol, Beijing 100083, Peoples R China.
   [Isaak, Cara K.; Karmin, O.; Siow, Yaw L.] Univ Manitoba, Dept Physiol, Winnipeg, MB R3E 0W3, Canada.
   [Karmin, O.] Univ Manitoba, Dept Anim Sci, Winnipeg, MB R3T 2N2, Canada.
C3 University of Manitoba; Children's Hospital Research Institute of
   Manitoba (CHRIM); Agriculture & Agri Food Canada; Saint Boniface
   Hospital; Beijing Forestry University; University of Manitoba;
   University of Manitoba
RP Siow, YL (corresponding author), Agr & Agri Food Canada, St Boniface Hosp, Res Ctr, Canadian Ctr Agri Food Res Hlth & Med, 351 Tache Ave,R2010, Winnipeg, MB R2H 2A6, Canada.
EM YawChris.Siow@agr.gc.ca
RI ; Siow, Yaw/AGE-1903-2022; Liu, Yujun/H-3661-2015
OI O, Karmin/0000-0002-2163-9458; Siow, Yaw/0000-0001-6623-2881; Liu,
   Yujun/0000-0001-6588-3359
FU Heart and Stroke Foundation of Manitoba; Canadian Foundation of
   Innovation; Manitoba Research Innovation Fund; China Ministry of
   Education (MOE)-AAFC PhD Research Program; Manitoba Health Research
   Council; estate of Margurite Germaine Jerome
FX This study is funded in part by the Heart and Stroke Foundation of
   Manitoba, the Canadian Foundation of Innovation and the Manitoba
   Research Innovation Fund. Liwei Sun is supported by the China Ministry
   of Education (MOE)-AAFC PhD Research Program and is jointly supervised
   by Yujun Liu and YL Slow. Cara Isaak is a recipient of a studentship
   from the Manitoba Health Research Council and was supported by the
   estate of Margurite Germaine Jerome.
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NR 42
TC 80
Z9 93
U1 1
U2 30
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
J9 LIFE SCI
JI Life Sci.
PD SEP 4
PY 2012
VL 91
IS 5-6
BP 151
EP 158
DI 10.1016/j.lfs.2012.06.026
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA 996VQ
UT WOS:000308123300001
PM 22771701
DA 2026-05-27
ER

PT J
AU Lu, RF
   Wu, YG
   Guo, HG
   Huang, XM
AF Lu, Rufeng
   Wu, Yueguo
   Guo, Honggang
   Huang, Xiaomin
TI Salidroside Protects Lipopolysaccharide-Induced Acute Lung Injury in
   Mice
SO DOSE-RESPONSE
LA English
DT Article
DE salidroside; lipopolysaccharide; acute lung injury; nuclear factor-kappa
   B; Toll-like receptor 4
ID NF-KAPPA-B; ACTIVATION; CELLS
AB Salidroside (SDS) has been reported to have anti-inflammatory properties. The objective of this study was to investigate the protective effect of SDS on lipopolysaccharide (LPS)-induced acute lung injury (ALI) in mice. BALB/c mice were pretreated with SDS 1 hour before intranasal instillation of LPS. Seven hours after LPS administration, the myeloperoxidase in histology of lungs, lung wet/dry ratio, and inflammatory cells in the bronchoalveolar lavage fluid (BALF) were determined. The levels of proinflammatory cytokines, tumor necrosis factor a (TNF-alpha), interleukin-1 beta (IL 1 beta), and IL-6 in the BALF were measured by enzyme-linked immunosorbent assay. The expression of Toll-like receptor 4 (TLR4), inhibitor of nuclear factor-kappa B (I kappa B-alpha), and nuclear factor-kappa B (NF-kappa B) p65 was detected by Western blot. The SDS reduced the inflammatory cells in BALF, decreased the wet/dry ratio of lungs, attenuated the LPS-induced histological alterations in the lung, and inhibited the production of TNF-alpha, IL-l beta, and IL-6. Western blot showed that SDS efficiently inhibited the phosphorylation of I kappa B-alpha, p65 NF-kappa B, and the expression of TLR4. These data show that the anti-inflammatory effects of SDS (at least 20 mg/kg) against LPS-induced ALI due to its ability to inhibit TLR4 mediated the NF-kappa B signaling pathways. The SDS may represent a novel strategy for treating LPS-induced ALI.
C1 [Lu, Rufeng; Huang, Xiaomin] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Emergency, Hangzhou 310006, Zhejiang, Peoples R China.
   [Wu, Yueguo] Zhejiang Acad Med Sci, Inst Mat Med, Hangzhou, Zhejiang, Peoples R China.
   [Guo, Honggang] Zhejiang Acad Med Sci, Key Lab Expt Anim & Safety Evaluat, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Academy of Medical
   Sciences; Zhejiang Academy of Medical Sciences
RP Huang, XM (corresponding author), Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Emergency, Hangzhou 310006, Zhejiang, Peoples R China.
EM mxh251770@aliyun.com
RI Huang, Xiaomin/GYJ-5985-2022
FU Scientific Research Fund of Zhejiang Province Chinese Medicine
   [2012ZB039]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the Scientific Research Fund of Zhejiang Province
   Chinese Medicine (2012ZB039).
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NR 18
TC 17
Z9 20
U1 0
U2 7
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-3258
J9 DOSE-RESPONSE
JI Dose-Response
PD OCT-DEC
PY 2016
VL 14
IS 4
AR 5
DI 10.1177/1559325816678492
PG 5
WC Pharmacology & Pharmacy; Radiology, Nuclear Medicine & Medical Imaging;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Radiology, Nuclear Medicine & Medical Imaging;
   Toxicology
GA EG3LI
UT WOS:000390944900005
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, T
   Tian, SW
   Gao, Z
   Li, Y
   Jia, HH
AF Zhang, Ting
   Tian, Shaowei
   Gao, Zhen
   Li, Yan
   Jia, Honghua
TI Engineering an Ancestral Glycosyltransferase for Biosynthesis of
   2-Phenylethyl-β-d-Glucopyranoside and Salidroside
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE ancestral sequence reconstruction; phenylethanoid glycosides;
   UDP-glycosyltransferase; 2-phenylethyl-beta-d-glucopyranoside;
   salidroside
ID MOLECULAR-DYNAMICS; LIFE
AB Phenylethanoid glycosides (PhGs) are naturally occurring glycosides derived from plants with various biological activities. Glycosyltransferases catalyze the production of PhGs from phenylethanols via a transglycosylation reaction. The low activity and stability of glycosyltransferase limit its industrial application. An ancestral glycosyltransferase, UGTAn85, with heat resistance, alkali resistance, and high stability was resurrected using ancestral sequence reconstruction technology. This enzyme can efficiently convert phenylethanols to PhGs. The optimal reaction temperature and pH for UGTAn85 were found to be 70 degrees C and pH 10.0, respectively. This study employed a combination of structure-guided rational design and co-evolution analysis to enhance its catalytic activity. Potential mutation sites were identified through computer-aided design, including homology modeling, molecular docking, Rosetta dock design, molecular dynamics simulation, and co-evolution analysis. By targeted mutagenesis, the UGTAn85 mutant Q23E/N65D exhibited a 2.2-fold increase in enzyme activity (11.85 U/mg) and elevated affinity (K (m) = 0.11 mM) for 2-phenylethanol compared to UGTAn85. Following a fed-batch reaction, 36.16 g/L 2-phenylethyl-beta-d-glucopyranoside and 51.49 g/L salidroside could be produced within 24 h, respectively. The findings in this study provide a new perspective on enhancing the stability and activity of glycosyltransferases, as well as a potential biocatalyst for the industrial production of PhGs.
C1 [Zhang, Ting; Tian, Shaowei; Gao, Zhen; Li, Yan; Jia, Honghua] Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, Nanjing 211816, Peoples R China.
C3 Nanjing Tech University
RP Li, Y; Jia, HH (corresponding author), Nanjing Tech Univ, Coll Biotechnol & Pharmaceut Engn, Nanjing 211816, Peoples R China.
EM liyan@njtech.edu.cn; hhjia@njtech.edu.cn
FU National Key R&D Program of China [2021YFC2101500]; Jiangsu Synergetic
   Innovation Center; PAPD
FX This work was financial supported by the National Key R&D Program of
   China (2021YFC2101500), the Jiangsu Synergetic Innovation Center for
   Advanced Bio-manufacture, and PAPD. The graphical abstract was drawn
   using Figdraw 2.0 (www.figdraw.com).
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NR 52
TC 17
Z9 18
U1 15
U2 94
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD AUG 27
PY 2024
VL 72
IS 36
BP 19966
EP 19976
DI 10.1021/acs.jafc.4c04381
EA AUG 2024
PG 11
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA F5F0O
UT WOS:001300235900001
PM 39189841
DA 2026-05-27
ER

PT J
AU Yang, SJ
   Yu, HY
   Kang, DY
   Ma, ZQ
   Qu, R
   Fu, Q
   Ma, SP
AF Yang, Shui-Jin
   Yu, Hai-Yang
   Kang, Dan-Yu
   Ma, Zhan-Qiang
   Qu, Rong
   Fu, Qiang
   Ma, Shi-Ping
TI Antidepressant-like effects of salidroside on olfactory
   bulbectomy-induced pro-inflammatory cytokine production and
   hyperactivity of HPA axis in rats
SO PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
LA English
DT Article
DE Salidroside; Olfactory bulbectomy; Antidepressant; Inflammation; GR; HPA
   axis
ID MAJOR DEPRESSIVE DISORDER; GLUCOCORTICOID RESISTANCE; STRESS; MODEL;
   MICE; PATHOPHYSIOLOGY; CORTICOSTERONE; EXPRESSION; DYSREGULATION;
   COMORBIDITY
AB Salidroside (SA) is the primary bioactive marker compound in the standardized extracts from Rhodiola rosea. Although it has potential antidepressant activity in a rat behavioral despair model, the mechanisms of antidepressant effect for SA remain unclear. The objective of this study was to evaluate the antidepressant effects of SA and to discuss the potential mechanisms in olfactory bulbectomized (OBX) rats. SA of 20, 40 mg/kg (p.o.) for 2 weeks notably alleviated OBX-induced hyperactivity in open field test, decreased immobility time in TST and FST. Chronic treatment with SA could remarkably reduce TNF-alpha and IL-1 beta, levels in hippocampus. Western blot showed that SA could markedly increase glucocorticoid receptor (GR) and brain-derived neurotrophic factor (BDNF) expression in the hippocampus. Besides, SA could also attenuate corticotropin-releasing hormone (CRH) expression in hypothalamus, as well as reducing significantly the levels of serum corticosterone. In conclusion, this study demonstrated that OBX rats treated with SA could significantly improve the depressive-like,behaviors. The antidepressant mechanisms of SA might be associated with its anti-inflammatory effects and the regulation of HPA axis activity. Reversal of abnormalities of GR may be partly responsible for those effects. These findings suggested that SA might become a beneficial agent to prevent and treat the depression. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Yang, Shui-Jin; Yu, Hai-Yang; Kang, Dan-Yu; Ma, Zhan-Qiang; Fu, Qiang; Ma, Shi-Ping] China Pharmaceut Univ, Dept Pharmacol Chinese Mat Med, Nanjing 210009, Jiangsu, Peoples R China.
   [Qu, Rong] Nanjing Univ Chinese Med, Discipline Chinese & Western Integrat Med, Nanjing 210046, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; Nanjing University of Chinese Medicine
RP Fu, Q (corresponding author), China Pharmaceut Univ, Dept Pharmacol Chinese Mat Med, Tongjiaxiang 24, Nanjing 210009, Jiangsu, Peoples R China.
EM fuqiang@cpu.edu.cn; spma@cpu.edu.cn
FU Natural Science Foundation of Jiangsu Province of China [BK2011630];
   Fundamental Research Funds for the Central Universities [JKZD2013009];
   Priority Academic Program Development of Jiangsu Higher Education
   Institutions and Research Innovation Program Project for Graduate
   Students in Jiangsu Province [CXZZ13_03]
FX This research was funded by grants from the Natural Science Foundation
   of Jiangsu Province of China (Grant No. BK2011630), the Fundamental
   Research Funds for the Central Universities (Program No. JKZD2013009)
   and the Priority Academic Program Development of Jiangsu Higher
   Education Institutions and Research Innovation Program Project for
   Graduate Students in Jiangsu Province (CXZZ13_03).
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NR 52
TC 68
Z9 79
U1 1
U2 39
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0091-3057
J9 PHARMACOL BIOCHEM BE
JI Pharmacol. Biochem. Behav.
PD SEP
PY 2014
VL 124
BP 451
EP 457
DI 10.1016/j.pbb.2014.07.015
PG 7
WC Behavioral Sciences; Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology; Pharmacology & Pharmacy
GA AR5JT
UT WOS:000343621900063
PM 25101546
DA 2026-05-27
ER

PT J
AU Shi, J
   Zhao, Q
   Hao, DD
   Miao, HX
   Wan, S
   Zhou, CH
   Wang, SY
   Chen, SY
   Shang, J
   Feng, TH
AF Shi, Jing
   Zhao, Qin
   Hao, Dou Dou
   Miao, Hong Xia
   Wan, Sha
   Zhou, Chao Hua
   Wang, Si Yu
   Chen, Si Yuan
   Shang, Jin
   Feng, Tian Hang
TI Gut microbiota profiling revealed the regulating effects of salidroside
   on iron metabolism in diabetic mice
SO FRONTIERS IN ENDOCRINOLOGY
LA English
DT Article
DE salidroside; diabetes; gut microbiota; iron metabolism; lactobacillus
ID RHODIOLA
AB BackgroundDiabetes is a common metabolic disease that is associated with gut microbiota dysbiosis and iron metabolism. Salidroside (SAL) is the main ingredient of the traditional Chinese herb Rhodiola, previous studies have shown that SAL could reshape the gut microbiota and limit iron accumulation. Therefore, it is possible that SAL can act as an alternative therapy for diabetes, and its underlying mechanism is worth exploring. MethodsSAL was used to treat diabetic db/db mice. Serum glucose and iron levels and the histopathology of myocardial fibres were evaluated. The gut microbiota composition was determined by 16S rRNA Illumina sequencing technology. ResultsTreatment with SAL significantly reduced blood glucose and ameliorated diabetic cardiomyopathy in diabetic db/db mice, which was accompanied by inhibited ferroptosis and iron accumulation. Furthermore, the 16S rRNA sequencing results showed that SAL induced a change in the gut microbiota composition. Overall, SAL could increase the proportion of probiotic bacteria and decrease Lactobacillus to improve gut microbiota. Specifically, SAL increased the ratio of Bacteroidetes to Firmicutes in diabetic mice. The most significant biomarker was the genus Lactobacillus between the MD group and the SAL group. In addition, COG and KEGG analyses suggested that SAL mainly participated in nutrient metabolism, among them iron metabolism was associated with the abundance of Lactobacillus. ConclusionsSAL could reduce the glucose level and protect against diabetic cardiomyopathy in diabetic mice, which might be mediated by the change in the gut microbiota and the regulation of iron metabolism. The findings suggested that SAL was a promising complementary option for diabetes therapy.
C1 [Shi, Jing; Zhao, Qin; Hao, Dou Dou; Wan, Sha; Zhou, Chao Hua; Wang, Si Yu; Chen, Si Yuan] Hosp CT, Hosp Chengdu Off Peoples Govt Tibetan Autonomous R, Chengdu, Peoples R China.
   [Miao, Hong Xia] Qingdao Cent Hosp, Dept Lab Med, Qingdao, Peoples R China.
   [Shang, Jin; Feng, Tian Hang] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Chengdu, Peoples R China.
C3 Sichuan Provincial People's Hospital; University of Electronic Science &
   Technology of China
RP Shang, J; Feng, TH (corresponding author), Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Chengdu, Peoples R China.
EM 935516165@qq.com; f_tianhang@163.com
RI Zhao, Qin/AAP-9101-2020; CHEN, SIYUAN/GVT-4628-2022
OI Zhao, Qin/0000-0002-3519-9190; 
FU Natural Science Foundation of Tibet Autonomous Region [XZ202101ZR0101G];
   Key Research Projects of the Hospital of Chengdu Office of People's
   Government of Tibetan Autonomous Region (Hospital.C.T.) [QH-1(2019)-03];
   Research Project of Sichuan Medical Association [S19072]
FX This work was supported by the Natural Science Foundation of Tibet
   Autonomous Region (XZ202101ZR0101G); the Key Research Projects of the
   Hospital of Chengdu Office of People's Government of Tibetan Autonomous
   Region (Hospital.C.T.) (QH-1(2019)-03); and the Research Project of
   Sichuan Medical Association (S19072).
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NR 36
TC 30
Z9 32
U1 1
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-2392
J9 FRONT ENDOCRINOL
JI Front. Endocrinol.
PD SEP 23
PY 2022
VL 13
AR 1014577
DI 10.3389/fendo.2022.1014577
PG 10
WC Endocrinology & Metabolism
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism
GA 5Q7IS
UT WOS:000874001000001
PM 36213297
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Su, ZX
   Kang, YQ
AF Su, Zhenxing
   Kang, Yunqin
TI Protective effect and regulatory mechanism of salidroside on skin
   inflammation induced by imiquimod in psoriasis mice
SO JOURNAL OF PHARMACOLOGICAL SCIENCES
LA English
DT Article
DE Psoriasis; Imiquimod; Salidroside; miR-369-3p; SMAD2
ID SMAD2; EXPRESSION
AB Salidroside (SAL) is a glucoside of tyrosol commonly existing in the roots of Rhodiola rosea. This study unveils the protective effect of SAL on skin inflammation in imiquimod (IMQ)-induced psoriasis. The mouse model of psoriasis was established by local application of IMQ, and SAL efficacy was evaluated through PASI scoring, H&E staining, and skin tissue pathology observation. The HaCaT cell model was established by interferon (IFN)-gamma induction, followed by MTT assay detection of cell viability, detection of ROS, SOD, MDA, and CAT levels in skin tissues and cells using reagent kits, ELISA detection of inflammatory factors (TNF-alpha, IL-6, IL-1 beta), and qRT-PCR detection of psoriasis-related genes (S100a9, Cxcl1, Cxcl2) as well as miR-369-3p and SMAD2 expressions. The binding relationship between miR-369-3p and SMAD2 was validated using dual-luciferase reporter assay. SAL treatment reduced PASI scores and alleviated psoriasis symptoms of IMQ-induced mice, and also augmented the viability and subsided the oxidative stress and inflammation of IFN-gamma-treated HaCaT cells. SAL treatment restrained miR-369-3p expression but elevated SMAD2 expression. Mechanistically, miR-369-3p targeted SMAD2 expression. miR-369-3p overexpression or SMAD2 inhibition partially offset the alleviating effect of SAL on psoriasis skin inflammation. In conclusion, SAL alleviates skin inflammation in IMQ-induced psoriasis mice via the miR-369-3p/SMAD2 axis.
C1 [Su, Zhenxing] Shanxi Med Univ, Hosp 1, Dept Dermatol, Taiyuan, Peoples R China.
   [Kang, Yunqin] Shanxi Med Univ, Hosp 1, Dept Thyroid Surg, Taiyuan, Peoples R China.
C3 Shanxi Medical University; Shanxi Medical University
RP Su, ZX (corresponding author), Shanxi Med Univ, Hosp 1, Dept Dermatol, Taiyuan, Peoples R China.
EM zhenxing_su@163.com
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NR 41
TC 9
Z9 10
U1 2
U2 10
PU JAPANESE PHARMACOLOGICAL SOC
PI KYOTO
PA EDITORIAL OFF, KANTOHYA BLDG GOKOMACHI-EBISUGAWA NAKAGYO-KU, KYOTO, 604,
   JAPAN
SN 1347-8613
EI 1347-8648
J9 J PHARMACOL SCI
JI J. Pharmacol. Sci.
PD MAR
PY 2024
VL 154
IS 3
BP 192
EP 202
DI 10.1016/j.jphs.2023.12.007
EA FEB 2024
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IR1N8
UT WOS:001167966200001
PM 38395520
OA gold
DA 2026-05-27
ER

PT J
AU Zhang, YT
   Jing, Q
   Hu, HM
   He, ZH
   Wu, T
   Guo, T
   Feng, NP
AF Zhang, Yongtai
   Jing, Qian
   Hu, Hongmei
   He, Zehui
   Wu, Tong
   Guo, Teng
   Feng, Nianping
TI Sodium dodecyl sulfate improved stability and transdermal delivery of
   salidroside-encapsulated niosomes via effects on zeta potential
SO INTERNATIONAL JOURNAL OF PHARMACEUTICS
LA English
DT Article
DE Liposome; Nanocarrier; Percutaneous; Permeation; Topical
ID CUTANEOUS DELIVERY; FORMULATION; PERMEATION; TRETINOIN; CARRIERS
AB Niosomes are novel carriers that show superior transdermal permeation enhancement but require the addition of charged stabilizers. In this study, niosomes were prepared using Span 40, cholesterol, and sodium dodecyl sulfate (SDS) as stabilizers for transdermal delivery of salidroside. At concentrations of 0.05-0.40% (w/v), SDS significantly increased the zeta potential of the nanovesicles from -18.5 +/- 3.2 to -157.0 +/- 5.2 mV and improved the stability of the niosomal formulations. Niosomes prepared with a Span 40:cholesterol molar ratio of 4:3 and 0.1% SDS showed good stability and the highest transdermal drug delivery among all tested formulations, with 2.75-fold higher transdermal flux of 20.26 +/- 1.05 mu g/(cm(2).h) than that of aqueous salidroside solution. However, excess SDS increased the negative charge on the vesicle surface and hence repulsion with skin cells, leading to reduced drug entrapment efficiency and cellular uptake of niosomes. Although SDS in the niosomes dose-dependently increased the in vitro cytotoxicity of the formulation in skin cells, HaCaT and CCC-ESF-1 cell viability was >= 80% for formulations containing <= 0.1% SDS. No significant irritation was observed on rat skin with once-a-day topical application of the niosomal formulations for 7 consecutive days. Thus, SDS is a promising stabilizer for nanomedicines, including niosomes, for transdermal administration.
C1 [Zhang, Yongtai; Jing, Qian; Hu, Hongmei; He, Zehui; Wu, Tong; Guo, Teng; Feng, Nianping] Shanghai Univ Tradit Chinese Med, Dept Pharmaceut Sci, Shanghai 201203, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Feng, NP (corresponding author), Shanghai Univ Tradit Chinese Med, Dept Pharmaceut Sci, Shanghai 201203, Peoples R China.
EM npfeng@shutcm.edu.cn
RI Feng, Nianping/ABG-5415-2021; Zhang, Yongtai/AEH-9113-2022
OI Guo, Teng/0000-0002-9213-7068; Zhang, Yongtai/0000-0002-1427-4868
FU National Natural Science Foundation of China [81673612]; Shanghai Talent
   Development Fund [2018099]
FX This work was financially supported by the National Natural Science
   Foundation of China [grant number 81673612] and Shanghai Talent
   Development Fund [grant number 2018099]. Yongtai Zhang, Qian Jing, and
   Hongmei Hu contributed equally to this work.
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NR 27
TC 75
Z9 82
U1 0
U2 57
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0378-5173
EI 1873-3476
J9 INT J PHARMACEUT
JI Int. J. Pharm.
PD APR 30
PY 2020
VL 580
AR 119183
DI 10.1016/j.ijpharm.2020.119183
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LH5DQ
UT WOS:000528806100041
PM 32112930
DA 2026-05-27
ER

PT J
AU Grech-Baran, M
   Syklowska-Baranek, K
   Pietrosiuk, A
AF Grech-Baran, Marta
   Syklowska-Baranek, Katarzyna
   Pietrosiuk, Agnieszka
TI Approaches of Rhodiola kirilowii and Rhodiola rosea field
   cultivation in Poland and their potential health benefits
SO ANNALS OF AGRICULTURAL AND ENVIRONMENTAL MEDICINE
LA English
DT Review
DE Rhodiola kirilowii; Rhodiola rosea; cultivation; salidroside; rosavins
ID TUMOR-INDUCED ANGIOGENESIS; DOUBLE-BLIND; IN-VITRO; SALIDROSIDE;
   EXTRACT; STRESS; L.; FATIGUE; SHR-5; PERFORMANCE
AB Numerous researches have been carried out on plants of the Rhodiola species, especially Rhodiola kirilowii (Regel) Maxim. and Rhodiola rosea. Various compounds have been reported to be isolated from R. kirilowii and R. rosea, including cyanogenic glycosides, monoterpene alcohols and their glycosides, aryl glycosides, phenylethanoids, phenylpropanoids and their glycosides (salidroside and rosavins respectively), as well as flavonoids, flavonlignans, proanthocyanidins and gallic acid derivatives and the latter have free radical scavenging capacity. The benefits claimed for Rhodiola include adapogenic, neuroprotective, anti-depresive anti-tumour and cardioprotective activities. Currently, the adaptogenic activity of Rhodiola compounds are properties evaluated mainly in human clinical trials. The mechanism of the action of Rhodiola extracts include affecting the levels of cortisol and NO by interactions with glucocorticoid receptors directly or via the c-Jun N-terminal protein kinase (JNK) pathway. However, the natural populations of R. rosea in Poland are threatened; therefore, the cultivation of R. rosea and alternative species R. kirilowii might be a possible solution for producing these kinds of plants in Poland in sufficient quantities and quality for pharmaceutical purposes. Lack of proven interaction with other drugs and no confirmed adverse effects during clinical trials encourages further investigation. These herb preparations ought to be studied extensively to establish their position as potential drugs for a variety of diseases.
C1 [Grech-Baran, Marta; Syklowska-Baranek, Katarzyna; Pietrosiuk, Agnieszka] Fac Pharm, Dept Pharmaceut Biol & Med Plant Biotechnol, PL-02097 Warsaw, Poland.
RP Syklowska-Baranek, K (corresponding author), Fac Pharm, Dept Pharmaceut Biol & Med Plant Biotechnol, Banacha 1, PL-02097 Warsaw, Poland.
EM ksyklowska@yahoo.com
RI Sykłowska-Baranek, Katarzyna/U-4650-2018; Pietrosiuk,
   Agnieszka/A-1320-2012
OI Sykłowska-Baranek, Katarzyna/0000-0002-9150-7872; Pietrosiuk,
   Agnieszka/0000-0001-7165-5336
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NR 50
TC 17
Z9 21
U1 3
U2 59
PU INST AGRICULTURAL MEDICINE
PI LUBLIN
PA JACZEWSKIEGO 2, PO BOX 185, 20-950 LUBLIN, POLAND
SN 1232-1966
EI 1898-2263
J9 ANN AGR ENV MED
JI Ann. Agr. Env. Med.
PY 2015
VL 22
IS 2
BP 281
EP 285
DI 10.5604/12321966.1152081
PG 5
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA CL0MC
UT WOS:000356635800019
PM 26094524
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Sun, P
   Song, SZ
   Jiang, S
   Li, X
   Yao, YL
   Wu, YL
   Lian, LH
   Nan, JX
AF Sun, Peng
   Song, Shun-Zong
   Jiang, Shuang
   Li, Xia
   Yao, You-Li
   Wu, Yan-Ling
   Lian, Li-Hua
   Nan, Ji-Xing
TI Salidroside Regulates Inflammatory Response in Raw 264.7 Macrophages via
   TLR4/TAK1 and Ameliorates Inflammation in Alcohol Binge Drinking-Induced
   Liver Injury
SO MOLECULES
LA English
DT Article
DE salidroside; inflammation; alcoholic liver injury; TLR4; TAK1
ID NITRIC-OXIDE SYNTHASE; I-KAPPA-B; LIPOPOLYSACCHARIDE; ACTIVATION;
   ENDOTOXEMIA; EXPRESSION; MEDIATORS; DISEASE; CELLS; TAK1
AB The current study was designed to investigate the anti-inflammatory effect of salidroside (SDS) and the underlying mechanism by using lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages in vitro and a mouse model of binge drinking-induced liver injury in vivo. SDS downregulated protein expression of toll-like receptor 4 (TLR4) and CD14. SDS inhibited LPS-triggered phosphorylation of LPS-activated kinase 1 (TAK1), p38, c-Jun terminal kinase (JNK), and extracellular signal-regulated kinase (ERK). Degradation of I kappa B-alpha and nuclear translocation of nuclear factor (NF)-kappa B were effectively blocked by SDS. SDS concentration-dependently suppressed LPS mediated inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) protein levels, as well as their downstream products, NO. SDS significantly inhibited protein secretion and mRNA expression of of interleukin (IL)-1 beta and tumor necrosis factor (TNF)-alpha. Additionally C57BL/6 mice were orally administrated SDS for continuous 5 days, followed by three gavages of ethanol every 30 min. Alcohol binge drinking caused the increasing of hepatic lipid accumulation and serum transaminases levels. SDS pretreatment significantly alleviated liver inflammatory changes and serum transaminases levels. Further investigation indicated that SDS markedly decreased protein level of IL-1 beta in serum. Taken together, these data implied that SDS inhibits liver inflammation both in vitro and in vivo, and may be a promising candidate for the treatment of inflammatory liver injury.
C1 [Sun, Peng; Song, Shun-Zong; Jiang, Shuang; Li, Xia; Yao, You-Li; Wu, Yan-Ling; Lian, Li-Hua; Nan, Ji-Xing] Yanbian Univ, Coll Pharm, Minist Educ, Key Lab Nat Resource ChangBai Mt & Funct Mol, Yanji 133002, Peoples R China.
   [Sun, Peng; Nan, Ji-Xing] Yanbian Univ Hosp, Clin Res Ctr, Yanji 133002, Peoples R China.
C3 Yanbian University; Yanbian University
RP Lian, LH; Nan, JX (corresponding author), Yanbian Univ, Coll Pharm, Minist Educ, Key Lab Nat Resource ChangBai Mt & Funct Mol, Yanji 133002, Peoples R China.; Nan, JX (corresponding author), Yanbian Univ Hosp, Clin Res Ctr, Yanji 133002, Peoples R China.
EM sunpeng3001@aliyun.com; szsong@ybu.edu.cn; 2014001052@ybu.edu.cn;
   lixiawo@163.com; 2015001055@ybu.edu.cn; ylwu@ybu.edu.cn;
   lhlian@ybu.edu.cn; jxnan@ybu.edu.cn
RI nan, ji-xing/H-5604-2018; Lian, Li-Hua/AEQ-0832-2022; Wu,
   Yan-Ling/ADR-0106-2022
OI nan, ji-xing/0000-0002-6221-4309; Lian, Li-Hua/0000-0002-6957-1317; Wu,
   Yan-Ling/0000-0001-9014-3264
FU National Natural Science Foundation of China [81260664, 81560597,
   81360658, 81660689]; Science and Technology Department of Jilin Province
   [20150520145JH, 20160101205JC]; Educational Commission of Jilin Province
   of China; Medical Scientific Research Foundation of Jilin Province of
   China [20142090]; Innovative Research Team Project of Key Laboratory at
   Yanbian University; Outstanding Young Talent Cultivation Project of Key
   Laboratory at Yanbian University [NRFM-YF201602]
FX This work was supported by the grants from the National Natural Science
   Foundation of China (81260664 and 81560597 to L.-H. Lian; 81360658 and
   81660689 to J.-X. Nan) and partially by Science and Technology Planning
   Projects from the Science and Technology Department of Jilin Province
   (20150520145JH and 20160101205JC L.-H. Lian), "Double Ten" Cultivation
   Project from the Educational Commission of Jilin Province of China
   (2014, to J.-X. Nan) and Medical Scientific Research Foundation of Jilin
   Province of China (20142090, to J.-X. Nan). This work was also supported
   in part by the Innovative Research Team Project (to J.-X. Nan) and
   Outstanding Young Talent Cultivation Project (NRFM-YF201602, to L.-H.
   Lian) of Key Laboratory at Yanbian University.
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NR 39
TC 46
Z9 53
U1 3
U2 28
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD NOV
PY 2016
VL 21
IS 11
AR 1490
DI 10.3390/molecules21111490
PG 13
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EE9AO
UT WOS:000389918200072
PM 27834881
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhu, LP
   Wei, TT
   Chang, XY
   He, H
   Gao, J
   Wen, ZL
   Yan, TH
AF Zhu, Lingpeng
   Wei, Tingting
   Chang, Xiayun
   He, He
   Gao, Jin
   Wen, Zhengli
   Yan, Tianhua
TI Effects of Salidroside on Myocardial Injury In Vivo In Vitro via
   Regulation of Nox/NF-κB/AP1 Pathway
SO INFLAMMATION
LA English
DT Article
DE salidroside; myocardial injury; NADPH oxidases 2 and 4; NF-kappa B;
   isoproterenol
ID DISEASE; CELLS; RATS
AB Salidroside (Sal), a phenylpropanoid glycoside isolated from a popular traditional Chinese medicinal plant Rhodiola rosea L., possesses multiple pharmacological actions. This aim of this study is to investigate the effects of Sal against isoproterenol (ISO)-induced myocardial ischemia. Fifty male Sprague-Dawley rats were randomized equally to five groups: control group, ISO group, Sal (20 mg/kg; 40 mg/kg) treatments groups, and propranolol (Pro, 15 mg/kg) group. Rats were treated for 14 days and then given ISO (80 mg/kg) for 2 consecutive days by subcutaneous injection. In vitro, we used H9C2 cells to investigate the effects of Sal against hypoxia-reoxygenation. ST-segment elevation was measured after the last administration. Serum levels of creatine kinase (CK), lactate dehydrogenase (LDH), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), superoxide dismutase (SOD), and malondialdehyde (MDA); levels of NADPH oxidases 2 and 4 (Nox2 and Nox4), NF-kappa BP65, and AP1 in heart, and H9C2 cells were measured by Western blot. The hearts were excised for determining microscopic examination, SOD, and MDA measurements. Sal decreased the ST elevation induced by ISO, decreased serum levels of CK-MB, LDH, TNF-alpha, IL-6, SOD, and MDA. In addition, Sal increased SOD activity and decreased MDA content in myocardial tissue. Sal also decreased Nox2 and 4, NF-kappa BP65, P-NF-kappa BP65, and AP1 protein levels in the heart. The results support a further study of Sal as potential treatments for ischemic heart disease.
C1 [Zhu, Lingpeng; Wei, Tingting; Chang, Xiayun; He, He; Gao, Jin; Yan, Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Jiangsu, Peoples R China.
C3 China Pharmaceutical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Tongjiaxiang 24, Nanjing, Jiangsu, Peoples R China.
EM yantianhuabest@126.com
RI he, he/JPL-3505-2023; Su, Tianyuan/Y-7054-2019
FU National twelve five major drug discovery project [2011ZX09102-002-01]
FX This work was supported by National twelve five major drug discovery
   project (2011ZX09102-002-01).
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NR 9
TC 71
Z9 79
U1 0
U2 30
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD AUG
PY 2015
VL 38
IS 4
BP 1589
EP 1598
DI 10.1007/s10753-015-0134-0
PG 10
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA CM4PD
UT WOS:000357666000024
PM 25682470
DA 2026-05-27
ER

PT J
AU He, SM
   Fan, HY
   Sun, B
   Yang, MP
   Liu, HX
   Yang, JW
   Liu, JX
   Luo, SZ
   Chen, ZH
   Zhou, J
   Xia, L
   Zhang, SL
   Yan, B
AF He, Shumei
   Fan, Hongyan
   Sun, Bin
   Yang, Meipan
   Liu, Hongxu
   Yang, Jianwei
   Liu, Jianxin
   Luo, Sizhu
   Chen, Zihan
   Zhou, Jing
   Xia, Lu
   Zhang, Shulin
   Yan, Bo
TI Tibetan medicine salidroside improves host anti-mycobacterial response
   by boosting inflammatory cytokine production in zebrafish
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE mycobacterium; salidroside; zebrafish; innate immunity; neutrophil;
   macrophage; Tnfa
ID MEDIATES RESISTANCE; DISEASE RESISTANCE; IMMUNE-RESPONSE; TUBERCULOSIS;
   SUSCEPTIBILITY; MYCOBACTERIA; INFECTION; INSIGHTS; MODEL
AB The treatment for tuberculosis (TB), especially multidrug-resistant TB (MDR-TB), has a prolonged cycle which can last up to a year. This is partially due to the lack of effective therapies. The development of novel anti-TB drugs from the perspective of host immune regulation can provide an important supplement for conventional treatment strategies. Salidroside (SAL), a bioactive component from the Tibetan medicine Rhodiola rosea, has been used in the treatment of TB, although its mechanism remains unclear. Here, the bacteriostatic effect of SAL in vivo was first demonstrated using a zebrafish-M. marinum infection model. To further investigate the underlying mechanism, we then examined the impact of SAL on immune cell recruitment during wound and infection. Increased macrophage and neutrophil infiltrations were found both in the vicinity of the wound and infection sites after SAL treatment compared with control, which might be due to the elevated chemokine expression levels after SAL treatment. SAL treatment alone was also demonstrated to improve the survival of infected zebrafish larvae, an effect that was amplified when combining SAL treatment with isoniazid or rifampicin. Interestingly, the reduced bacterial burden and improved survival rate under SAL treatment were compromised in tnf alpha-deficient embryos which suggests a requirement of Tnf alpha signaling on the anti-mycobacterial effects of SAL. In summary, this study provides not only the cellular and molecular mechanisms for the host anti-mycobacterial effects of the Tibetan medicine SAL but also proof of concept that combined application of SAL with traditional first-line anti-TB drugs could be a novel strategy to improve treatment efficacy.
C1 [He, Shumei; Fan, Hongyan; Yang, Meipan; Liu, Hongxu; Yang, Jianwei; Liu, Jianxin; Luo, Sizhu] Xizang Minzu Univ, Sch Med, Key Lab Mol Mechanist & Intervent Res Plateau Dis, Key Lab High Altitude Hypoxia Environm & Life Hlth, Xianyang, Peoples R China.
   [Fan, Hongyan; Liu, Hongxu; Yang, Jianwei; Liu, Jianxin; Luo, Sizhu; Chen, Zihan; Zhou, Jing; Xia, Lu; Zhang, Shulin; Yan, Bo] Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China.
   [Sun, Bin] Shihezi Univ, Dept Stomatol, Affiliated Hosp 1, Med Coll, Shihezi, Peoples R China.
   [Chen, Zihan; Zhou, Jing] China Three Gorges Univ, Med Coll, Yichang, Peoples R China.
   [Zhang, Shulin] Shanghai Jiao Tong Univ, Dept Immunol & Microbiol, Sch Med, Shanghai, Peoples R China.
C3 Xizang Minzu University; Fudan University; Shihezi University; China
   Three Gorges University; Shanghai Jiao Tong University
RP He, SM (corresponding author), Xizang Minzu Univ, Sch Med, Key Lab Mol Mechanist & Intervent Res Plateau Dis, Key Lab High Altitude Hypoxia Environm & Life Hlth, Xianyang, Peoples R China.; Zhang, SL; Yan, B (corresponding author), Fudan Univ, Shanghai Publ Hlth Clin Ctr, Shanghai, Peoples R China.; Zhang, SL (corresponding author), Shanghai Jiao Tong Univ, Dept Immunol & Microbiol, Sch Med, Shanghai, Peoples R China.
EM shumeihe2021@sina.com; shulinzhang@sjtu.edu.cn; bo.yan@shphc.org.cn
RI lu, xia/LIF-7200-2024; Chen, Zi-Han/U-1530-2019
FU National Natural Science Foundation of China; Shanghai "Science and
   Technology Innovation Action Plan" Medical Innovation Research Special
   Project [81801977, 81871613]; Outstanding Youth Training Program of
   Shanghai Municipal Health Commission [22Y11920500]; Shanghai Sailing
   Program [2018YQ54]; Natural Science Foundation of Xizang (Tibet)
   Autonomous Region [18YF1420400];  [XZ2019ZR G-37(z)]
FX This work was supported by the National Natural Science Foundation of
   China (81801977 to BY; 81871613 to SZ), the Shanghai "Science and
   Technology Innovation Action Plan" Medical Innovation Research Special
   Project (22Y11920500 to BY), the Outstanding Youth Training Program of
   Shanghai Municipal Health Commission (2018YQ54 to BY), the Shanghai
   Sailing Program (18YF1420400 to BY), and the Natural Science Foundation
   of Xizang (Tibet) Autonomous Region [No. XZ2019ZR G-37(z)].
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NR 53
TC 5
Z9 9
U1 2
U2 26
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD AUG 31
PY 2022
VL 13
AR 936295
DI 10.3389/fphar.2022.936295
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 4O4SU
UT WOS:000854690600001
PM 36120339
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wei, XL
   Li, JY
   Liu, H
   Niu, CG
   Chen, D
AF Wei, Xiaoling
   Li, Jiayang
   Liu, Hui
   Niu, Chenguang
   Chen, Dong
TI Salidroside promotes the osteogenic and odontogenic differentiation of
   human dental pulp stem cells through the BMP signaling pathway
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE salidroside; human dental pulp stem cells; osteogenic differentiation;
   odontogenic differentiation
ID ODONTOBLAST DIFFERENTIATION; BONE REGENERATION; RUNX2; TISSUE
AB Regenerative endodontics, as an alternative approach, aims to regenerate dental pulp-like tissues and is garnering the attention of clinical dentists. This is due to its reported biological benefits for dental therapeutics. Stem cells and their microenvironment serve an important role in the process of pulp regeneration. Regulation of the stem cell microenvironment and the directed differentiation of stem cells is becoming a topic of intensive research. Salidroside (SAL) is extracted from the root of Rhodiola rosea and it has been reported that SAL exerts antiaging, neuroprotective, hepatoprotective, cardioprotective and anticancer effects. However, the ability of SAL to regulate the osteo/odontogenic differentiation of hDPSCs remains to be elucidated. In the present study, the effect of SAL on the proliferation and osteogenic/odontogenic differentiation of human dental pulp stem cells (hDPSCs) was investigated. This was achieved by performing CCK-8 ARS staining assay, reverse transcription-quantitative PCR to detect mRNA of ALP, OSX, RUNX2, OCN, DSPP and BSP, western blotting to detect the protein of MAPK, Smad1/5/8, OSX, RUNX2, BSP and GAPDH and immunofluorescence assays to detect DSPP. The results indicated that SAL promoted the cell viability and the osteogenic/odontogenic differentiation of hDPSCs whilst increasing the expression of genes associated with osteogenic/odontogenic differentiation by ARS staining assay. In addition, SAL promoted osteogenic and odontogenic differentiation by activating the phosphorylation of Smad1/5/8. Collectively, these findings suggest that SAL promoted the osteogenic and odontogenic differentiation of hDPSCs activating the BMP signaling pathway.
C1 [Wei, Xiaoling; Li, Jiayang; Liu, Hui; Chen, Dong] Fudan Univ, Dept Endodont, Shanghai Stomatol Hosp, 356 Beijing Rd, Shanghai 200001, Peoples R China.
   [Wei, Xiaoling; Li, Jiayang; Liu, Hui; Niu, Chenguang; Chen, Dong] Fudan Univ, Shanghai Key Lab Craniomaxillofacial Dev & Dis, Shanghai Stomatol Hosp, Shanghai 200001, Peoples R China.
   [Niu, Chenguang] Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Endodont, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
   [Niu, Chenguang] Shanghai Jiao Tong Univ, Coll Stomatol, Shanghai 200011, Peoples R China.
C3 Fudan University; Fudan University; Shanghai Jiao Tong University;
   Shanghai Jiao Tong University
RP Chen, D (corresponding author), Fudan Univ, Dept Endodont, Shanghai Stomatol Hosp, 356 Beijing Rd, Shanghai 200001, Peoples R China.; Niu, CG (corresponding author), Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 9, Dept Endodont, Sch Med, 639 Zhizaoju Rd, Shanghai 200011, Peoples R China.
EM niuchg09@alumni.sjtu.edu.cn; chendong19690124@126.com
RI Chenguang, Niu/PSL-5271-2026
OI Chenguang, Niu/0000-0002-3153-3892
FU Project of the Shanghai Municipal Commission of Health and Family
   Planning [201740051]
FX The present study was supported by a grant from the Project of the
   Shanghai Municipal Commission of Health and Family Planning (grant no.
   201740051).
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NR 47
TC 11
Z9 11
U1 1
U2 20
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JAN
PY 2022
VL 23
IS 1
AR 55
DI 10.3892/etm.2021.10977
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA XF6NN
UT WOS:000724186600001
PM 34917181
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, SY
   Zhao, XX
   Yang, SX
   Chen, BP
   Shi, J
AF Wang, Shiying
   Zhao, Xinxin
   Yang, Suxia
   Chen, Baoping
   Shi, Jun
TI Salidroside alleviates high glucose-induced oxidative stress and
   extracellular matrix accumulation in rat glomerular mesangial cells by
   the TXNIP-NLRP3 inflammasome pathway
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Diabetic nephropathy; Extracellular matrix accumulation; TXNIP
   inflammasome; Oxidative stress; Salidroside
ID PROLIFERATION; NEPHROPATHY; INHIBITION; ACTIVATION; INJURY
AB Diabetic nephropathy (DN) is a metabolic disease characterized by mesangial cell proliferation and extracellular matrix (ECM) accumulation. Salidroside (SAL) is the major ingredient in Rhodiola rosea and possesses beneficial effects on DN. This study aimed to evaluate the effect of SAL on high glucose (HG)-induced oxidative stress and ECM accumulation and the underlying mechanism. Rat glomerular mesangial cells HBZY-1 were induced by high glucose (HG) in the presence or absence of SAL. Cell proliferation was measured by CCK-8 assay. The reactive oxygen species (ROS) level, malondialdehyde (MDA) level and superoxide dismutase (SOD) activity were detected to evaluate oxidative stress. The expression levels of ECM proteins including fibronectin (FN) and type IV collagen (Coll IV) were detected by qRT-PCR and western blot analysis. The expressions of thioredoxin-interacting protein (TXNIP), nod-like receptor protein 3 (NLRP3), apoptosis-associated speck-like protein containing CARD (ASC), and caspase-1 were assessed by western blot. Si-TXNIP or si-NC was transfected into HBZY-1 cells to inhibit TXNIP-NLRP3 inflammasome pathway. The results showed that SAL treatment alleviated HG-induced cell proliferation. SAL reduced the levels of ROS and MDA, and induced the SOD activity. Besides, the mRNA and protein expressions of FN and Coll IV were decreased by SAL. The expression levels of TXNIP, NLRP3, ASC, and caspase-1 were reduced in the SAL treated cells. In addition, TXNIP knockdown inhibited TXNIP-NLRP3 inflammasome activation and suppressed HG-induced cell proliferation, oxidative stress, and ECM accumulation. In conclusion, SAL alleviated HG-induced oxidative stress and ECM accumulation in rat glomerular mesangial cells by the TXNIP-NLRP3 inflammasome pathway.
C1 [Wang, Shiying; Zhao, Xinxin; Yang, Suxia; Chen, Baoping; Shi, Jun] Henan Univ, Huaihe Hosp, Nephrol Dept, 115 Ximen St, Kaifeng 475000, Henan, Peoples R China.
C3 Henan University
RP Shi, J (corresponding author), Henan Univ, Huaihe Hosp, Nephrol Dept, 115 Ximen St, Kaifeng 475000, Henan, Peoples R China.
EM shijun_hh@163.com
FU Scientific and technological Key Project of Henan Province [201003089]
FX This work was financially supported by Scientific and technological Key
   Project of Henan Province (No. 201003089).
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NR 25
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U1 2
U2 41
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD DEC 25
PY 2017
VL 278
BP 48
EP 53
DI 10.1016/j.cbi.2017.10.012
PG 6
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA FQ4BG
UT WOS:000418302000007
PM 29031534
DA 2026-05-27
ER

PT J
AU Shi, SM
   Geng, ZJ
   Yu, XF
   Hu, B
   Liu, LY
   Chi, ZC
   Qu, LY
   Zhang, MJ
   Jin, YX
AF Shi, Shuming
   Geng, Zhaojun
   Yu, Xianfeng
   Hu, Bing
   Liu, Liying
   Chi, Zhichao
   Qu, Linyi
   Zhang, Mingjun
   Jin, Yongxun
TI Salidroside Supplementation Affects In Vitro Maturation and
   Preimplantation Embryonic Development by Promoting Meiotic Resumption
SO GENES
LA English
DT Article
DE embryos; MAPK; maturation; mitochondria; oocytes; Sal; ROS
ID OXIDATIVE STRESS; PORCINE OOCYTES; CELLS; ACTIVATION; APOPTOSIS;
   PROLIFERATION; COMPETENCE; PROTECTION; MAPK; DNA
AB Simple Summary The in vitro maturation (IVM) of oocytes is often delayed due to oxidative stress and mitochondrial function, resulting in a decrease in oocyte quality. We used a porcine oocyte model to check the effects of salidroside supplementation during IVM on the quality and developmental competence of oocytes. Using a variety of experimental methods, the efficiency of salidroside in protecting mature oocytes, apoptosis, and mitochondrial function was observed.Abstract Salidroside (Sal) possesses several pharmacological activities, such as antiaging, and anti-inflammatory, antioxidant, anticancer activities, and proliferation-promoting activities, but the effects of Sal on oocytes have rarely been reported. In the present study, we evaluated the beneficial effects of Sal, which is mainly found in the roots of Rhodiola. Porcine cumulus oocyte complexes were cultured in IVM medium supplemented (with 250 mu mol/L) with Sal or not supplemented with Sal. The maturation rate in the Sal group increased from 88.34 +/- 4.32% to 94.12 +/- 2.29%, and the blastocyst rate in the Sal group increased from 30.35 +/- 3.20% to 52.14 +/- 7.32% compared with that in the control group. The experimental groups showed significant improvements in the cumulus expansion area. Sal reduced oocyte levels of reactive oxygen species (ROS) and enhanced intracellular GSH levels. Sal supplementation enhanced the mitochondrial membrane potential (MMP), ATP level, and mtDNA copy number, which shows that Sal enhances the cytoplasmic maturation of oocytes. Oocytes in the Sal group exhibited slowed apoptosis and reduced DNA breakage. Cell cycle signals and oocyte meiosis play important roles in oocyte maturation. The mRNA expressions of the MAPK pathway and MAPK phosphorylation increased significantly in the Sal group. The mRNA expression of the oocyte meiosis gene also increased significantly. These results show that Sal enhances the nuclear maturation of oocytes. Moreover, Sal increased the number of blastocyst cells, the proliferation of blastocysts, and the expressions of pluripotency genes. Sal down-regulated apoptosis-related genes and the apoptotic cell rate of blastocysts. In summary, our results demonstrate that Sal is helpful to improving the quality of porcine oocytes in vitro, and their subsequent embryonic development.
C1 [Shi, Shuming; Geng, Zhaojun; Yu, Xianfeng; Liu, Liying; Chi, Zhichao; Qu, Linyi; Jin, Yongxun] Jilin Univ, Coll Anim Sci, Jilin Prov Key Lab Anim Model, Changchun 130062, Peoples R China.
   [Hu, Bing; Zhang, Mingjun] Jilin Univ, Coll Anim Sci, Anim Genome Editing Technol Innovat Ctr, Changchun 130062, Peoples R China.
C3 Jilin University; Jilin University
RP Jin, YX (corresponding author), Jilin Univ, Coll Anim Sci, Jilin Prov Key Lab Anim Model, Changchun 130062, Peoples R China.; Zhang, MJ (corresponding author), Jilin Univ, Coll Anim Sci, Anim Genome Editing Technol Innovat Ctr, Changchun 130062, Peoples R China.
EM shism20@mails.jlu.edu.cn; gengzj20@mails.jlu.edu.cn;
   xianfeng79@jlu.edu.cn; hubing21@mails.jlu.edu.cn;
   liuliying22@mails.jlu.edu.cn; chizc9919@mails.jlu.edu.cn;
   quly9919@mails.jlu.edu.cn; mjzhang@jlu.edu.cn; jyx0429@126.com
RI ; Liu, Liying/T-4397-2019
OI Yu, Xianfeng/0000-0003-0589-2178; Geng, Zhaojun/0009-0005-8318-9367; 史,
   书铭/0009-0007-0594-8000; 
FU Jilin Provincial Natural Science Foundation of China [20210101014JC];
   international cooperation project [3D5205987203]
FX This research was funded by the earmarked fund for the Jilin Provincial
   Natural Science Foundation of China (20210101014JC), and an
   international cooperation project (3D5205987203).
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NR 62
TC 10
Z9 11
U1 0
U2 11
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4425
J9 GENES-BASEL
JI Genes
PD SEP
PY 2023
VL 14
IS 9
AR 1729
DI 10.3390/genes14091729
PG 16
WC Genetics & Heredity
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Genetics & Heredity
GA T6MR3
UT WOS:001079112500001
PM 37761869
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Jin, YT
   Wang, Y
   Wang, C
   Zhang, LL
   Gao, DD
   Liu, HZ
   Cao, QW
   Tian, CC
   Bian, YH
   Wang, Y
AF Jin, Yutong
   Wang, Yao
   Wang, Chuan
   Zhang, Lingling
   Gao, Dandan
   Liu, Haizhao
   Cao, Qingwen
   Tian, Chenchen
   Bian, Yuhong
   Wang, Yue
TI Salidroside inhibits osteoclast differentiation based on
   osteoblast-osteoclast interaction via HIF-1α pathway
SO CHINESE JOURNAL OF NATURAL MEDICINES
LA English
DT Article
DE Salidroside; Hypoxia-inducible factor-1 alpha; Osteoblast; Osteoclast;
   Osteoclastogenesis
ID HYPOXIA-INDUCIBLE FACTOR; BONE-RESORPTION; CELLS; OSTEOPOROSIS;
   ANGIOGENESIS; ACTIVATION
AB This study investigated the regulatory potential of salidroside (SAL), a primary active compound in Rhodiola rosea L., on osteoclast differentiation by modulating the hypoxia-inducible factor 1-alpha (HIF-1 alpha) pathway in osteoblasts. Luciferase reporter assay and chromatin immunoprecipitation (ChIP) assay were employed to validate whether the receptor activator of nuclear factor-kappa B ligand (RANKL) is the downstream target gene of HIF-1 alpha in osteoblasts. The study also utilized lipopolysaccharide (LPS)-induced mouse osteolysis to examine the impact of SAL on osteolysis in vivo. Furthermore, conditioned medium (CM) from SAL-pretreated osteoblasts was used to investigate the paracrine effects on osteoclastogenesis through the HIF-1 alpha pathway. Hypoxic condition-induced overexpression of HIF-1 alpha upregulated RANKL levels by binding to the RANKL promoter and enhancing transcription in osteoblastic cells. In vivo, SAL significantly alleviated bone tissue hypoxia and decreased the expression of HIF-1 alpha by downregulating the expression of RANKL, vascular endothelial growth factor (VEGF), interleukin 6 (IL-6), and angiopoietin-like 4 (ANGPTL4). In the paracrine experiment, conditioned media from SAL-pretreated osteoblasts inhibited differentiation through the HIF-1 alpha/RANKL, VEGF, IL-6, and ANGPTL4 pathways. RANKL emerges as the downstream target gene regulated by HIF-1 alpha in osteoblasts. SAL significantly alleviates bone tissue hypoxia and bone loss in LPS-induced osteolysis through the HIF-1 alpha/RANKL, VEGF, IL-6, and ANGPTL4 pathways. SAL inhibits osteoclast differentiation by regulating osteoblast paracrine secretion.
C1 [Jin, Yutong; Wang, Yao; Zhang, Lingling; Gao, Dandan; Liu, Haizhao; Cao, Qingwen; Tian, Chenchen; Bian, Yuhong; Wang, Yue] Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 301617, Peoples R China.
   [Jin, Yutong; Bian, Yuhong] Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Dept Oncol, Tianjin 300193, Peoples R China.
   [Wang, Chuan] Tianjin Med Univ, Chu Hsien I Mem Hosp, NHC Key Lab Hormones & Dev, Dept Stomatol, Tianjin 300134, Peoples R China.
   [Wang, Chuan] Tianjin Med Univ, Tianjin Inst Endocrinol, Tianjin 300134, Peoples R China.
   [Wang, Chuan] Tianjin Med Univ, Dept Stomatol, Tianjin Key Lab Metab Dis, Tianjin 300134, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine; Tianjin Medical University; Tianjin
   Medical University; Tianjin Medical University
RP Bian, YH; Wang, Y (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 301617, Peoples R China.; Bian, YH (corresponding author), Tianjin Univ Tradit Chinese Med, Teaching Hosp 1, Dept Oncol, Tianjin 300193, Peoples R China.
EM bianyuhong_2012@163.com; wangyue6808@126.com
FU National Natural Science Foundation of China [81572852, 82104671]; Great
   Program of the Science Foundation of Tianjin [18JCZDJC 33200];
   Heilongjiang Province Fund [LH2020H102]; Tianjin Key Medical Discipline
   (Specialty) Construction Project [TJYXZDXK-032A]
FX This research was supported by grants from the National Natural Science
   Foundation of China (Nos. 81572852 and 82104671) , the Great Program of
   the Science Foundation of Tianjin (No. 18JCZDJC 33200) , Heilongjiang
   Province Fund (No. LH2020H102) , and Tianjin Key Medical Discipline
   (Specialty) Construction Project (No.TJYXZDXK-032A) .
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NR 49
TC 6
Z9 6
U1 2
U2 7
PU CHINESE JOURNAL NATURAL MEDICINES
PI NANJING
PA 24, TONGJIA XIANG, NANJING, 210009, PEOPLES R CHINA
SN 2095-6975
EI 1875-5364
J9 CHIN J NAT MEDICINES
JI Chin. J. Nat. Med.
PD MAY
PY 2025
VL 23
IS 5
BP 572
EP 584
DI 10.1016/S1875-5364(25)60864-8
EA MAY 2025
PG 13
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA 2ZR3W
UT WOS:001495145600001
PM 40383613
DA 2026-05-27
ER

PT J
AU Si, PP
   Zhen, JL
   Cai, YL
   Wang, WJ
   Wang, WP
AF Si, Pei-Pei
   Zhen, Jun-Li
   Cai, Yun-Lei
   Wang, Wen-Jing
   Wang, Wei-Ping
TI Salidroside protects against kainic acid-induced status epilepticus
   via suppressing oxidative stress
SO NEUROSCIENCE LETTERS
LA English
DT Article
DE Salidroside; Protection; Kainic acid; Status epilepticus; Oxidative
   stress
ID ALZHEIMERS-DISEASE; DIABETIC-RATS; NITRIC-OXIDE; PATHWAY; ACTIVATION;
   MEMORY; DYSFUNCTION; AUTOPHAGY; DEFICITS; KAINATE
AB There are numerous mechanisms by which the brain generates seizures. It is well known that oxidative stress plays a pivotal role in status epilepticus (SE). Salidroside (SDS) extracted from Rhodiola rosea L. shows multiple bioactive properties, such as neuroprotection and antioxidant activity in vitro and in vivo. This study explored the role of SDS in kainic acid (KA)-induced SE and investigated the underlying mechanism. Latency to SE increased in the SDS-pretreated mice compared to the KA group, while the percentage of incidence of SE was significantly reduced. These results suggested that pretreatment with SDS not only delayed SE, but it also decreased the incidence of SE induced by KA. KA increased MDA level and reduced the production of SOD and GSH at multiple timepoints after KA administration. SDS inhibited the change of MDA, SOD and GSH induced by KA prior to SE onset, indicating that SDS protects against KA-induced SE via suppressing oxidative stress. Based on these results, we investigated the possible molecular mechanism of SDS. Pretreatment with SDS reversed the KA-induced decrease in AMP -activated protein kinase (AMPK); increased the sirtuin I (SIRT1) deacetylase activity in KA-treated mice, which had no demonstrable effect on SIRT1 mRNA and protein; and suppressed the KA-induced increase in Ace-FoxO1. These results showed that AMPKISIRT1/FoxO1 signaling is possibly the molecular mechanism of neuroprotection by SDS. (C) 2016 Elsevier Ireland Ltd. All rights reserved.
C1 [Si, Pei-Pei; Zhen, Jun-Li; Cai, Yun-Lei; Wang, Wen-Jing; Wang, Wei-Ping] Hebei Med Univ, Key Lab Neurol Hebei Prov, Hosp 2, Shijiazhuang 050071, Hebei, Peoples R China.
C3 Hebei Medical University
RP Wang, WP (corresponding author), Hebei Med Univ, Key Lab Neurol Hebei Prov, Hosp 2, Shijiazhuang 050071, Hebei, Peoples R China.
EM wpwang203@163.com
FU Natural Science Foundation of Hebei Province, China [C2014206400]
FX We thank Xiaorong Yang for her assistance in the preparation of the
   manuscript. This study was financially supported by the Natural Science
   Foundation of Hebei Province (No.C2014206400), China.
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NR 31
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Z9 46
U1 0
U2 21
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0304-3940
EI 1872-7972
J9 NEUROSCI LETT
JI Neurosci. Lett.
PD APR 8
PY 2016
VL 618
BP 19
EP 24
DI 10.1016/j.neulet.2016.02.056
PG 6
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DK0NS
UT WOS:000374610100004
PM 26940236
DA 2026-05-27
ER

PT J
AU Nguyen, PA
   Won, JS
   Cho, MK
AF Nguyen, Phuc Anh
   Won, Jong Soon
   Cho, Min Kyung
TI Acer tegmentosum Maxim and Bacillus subtilis-fermented
   products inhibit TNF-α-induced endothelial inflammation and vascular
   dysfunction of the retina: the role of tyrosol moiety in active
   compounds targeting Glu230 in SIRT1
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE <italic>Acer tegmentosum</italic> Maxim; anti-inflammation; NF-kappa B;
   SIRT1; tyrosol
ID NF-KAPPA-B; IN-VITRO; EXPRESSION; EXTRACT; METABOLISM; MODULATION;
   ACTIVATION; RELEASE; CELLS
AB Acer tegmentosum Maxim (AT) is a medicinal plant used to treat hepatic, neurological diseases, and cancer. However, the beneficial effects of AT on endothelial dysfunction have not been reported yet. In this study, we evaluated the effects of AT and the main compounds against TNF-alpha-mediated inflammatory responses and their possible mechanism of action. The anti-inflammatory effect and its molecular mechanism were analyzed by adhesion assay, immunoblotting, promoter-luciferase assay, ELISA, RT-PCR, immunocytochemistry, immunoprecipitation, siRNA gene knockdown, docking, and molecular dynamics simulation. AT and its compounds salidroside and tyrosol reduced TNF-alpha-induced adhesion between monocytes and endothelial cells. Fermentation of AT with Bacillus subtilis converted salidroside to tyrosol, which is salidroside's aglycone. The fermented AT product (ATF) potently inhibited TNF-alpha-mediated monocyte adhesion with higher potency than AT. AT or ATF abrogated TNF-alpha-induced expression of adhesion molecules (VCAM-1 and ICAM-1) and production of MCP-1 with the inhibition of phosphorylated MAP kinases. TNF-alpha-mediated NF-kappa B transactivation and RelA/p65 acetylation were suppressed by AT and ATF through the interaction of NF-kappa B with sirtuin-1 (SIRT1), an NAD+-dependent histone deacetylase. Sirt1 gene knockdown diminished the protective effects of AT and ATF against TNF-alpha-mediated signaling and inflammatory response. Interestingly, SIRT1 protein expression was significantly increased by ATF and tyrosol rather than by AT and salidroside, respectively. Molecular docking showed that the tyrosol moiety is critical for the interaction with Glu230 of SIRT1 (PDB ID: 4ZZH and 4ZZJ) for the deacetylase activity. Molecular dynamics revealed that tyrosol can induce the movement of the N-terminal domain toward the catalytic domain of SIRT1. This study demonstrates the potential of AT and ATF to prevent endothelial inflammation and vascular dysfunction of the retina by the MAPK/NF-kappa B/SIRT1 signaling pathways and targeting of the tyrosol moiety to Glu230 in SIRT1.
C1 [Nguyen, Phuc Anh; Won, Jong Soon; Cho, Min Kyung] Dongguk Univ, Coll Oriental Med, Dept Pharmacol, Gyeongju, South Korea.
C3 Dongguk University
RP Cho, MK (corresponding author), Dongguk Univ, Coll Oriental Med, Dept Pharmacol, Gyeongju, South Korea.
EM mkcho@dongguk.ac.kr
FU National Research Foundation of Korea (NRF) grant - Korean government
   (Ministry of Science and ICT) [2020R1A2C1012313]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   supported by the National Research Foundation of Korea (NRF) grant
   funded by the Korean government (Ministry of Science and ICT)
   (2020R1A2C1012313).
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NR 54
TC 2
Z9 2
U1 2
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD NOV 20
PY 2024
VL 15
AR 1392179
DI 10.3389/fphar.2024.1392179
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA O1K5K
UT WOS:001368801900001
PM 39635433
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liang, X
   Wu, Y
   Feng, Q
   Zhu, DY
   Huang, Q
   Wei, ZZ
   Ma, P
   Yang, X
   Bao, CY
   Bao, XY
AF Liang, Xiao
   Wu, Yang
   Feng, Qing
   Zhu, Deyu
   Huang, Qi
   Wei, Zhuangzhuang
   Ma, Ping
   Yang, Xu
   Bao, Cuiyu
   Bao, Xinyu
TI Synergies of dibutyl phthalate on high-fat diet can aggravate cardiac
   fibrosis/dysfunction and the protective effects of vitamin E and
   salidroside: A molecular toxicological study in Sprague-Dawley rats
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Article
DE Plastic-pollution derivative; Dibutyl phthalate; High fat diet; Cardiac
   fibrosis; Cardiac dysfunction; Pyroptosis; Hepatic lipid metabolism
   disorders; Salidroside
ID HEART-FAILURE; FIBROSIS; PATHWAYS; DISEASE; STRESS; UPDATE
AB Background: Dibutyl phthalate (DBP) is a pollutant associated with plastic contamination and is commonly used as a plasticizer. It is linked to various adverse health effects, including cardiovascular disease (CVD). There is an association between DBP and high-fat diet (HFD), with HFD also contributing to the development of CVD, including cardiac fibrosis. Cardiac fibrosis is characterized by chronic inflammation of myocardial tissue and is a significant contributor to CVD pathogenesis. Recent research provides evidence suggesting a potential link between environmental exposure to DBP and cardiac damage. However, it remains unclear whether DBP has a synergistic effect on HFD and whether the interaction between the two exacerbates cardiac fibrosis and dysfunction. Objectives: The aim of this study was to investigate the synergistic effects of DBP on cardiac fibrosis induced by HFD. Specifically, we elucidated the mechanisms underlying the synergistic effect of DBP on HFD-induced cardiac fibrosis, with a focus on oxidative stress, pyroptosis, and the disruption of hepatic lipid metabolism. Furthermore, we explored the protective effects of two antioxidants, salidroside (Sal) and vitamin E (VitE), against the exacerbation of cardiac fibrosis caused by the synergistic action of DBP and HFD. Methods: Male Sprague-Dawley (SD) rats were divided into ten groups: a blank control group (Saline); separate groups exposed to low, medium, and high doses of DBP (DBP0.01, DBP1, DBP50 mg/kg/day); a high-fat diet group (HFD); a synergy group combining high concentrations of DBP and a high-fat diet (DBP50 +HFD); and treatment groups with Vitamin E and salidroside (DBP50 +VitE, DBP50 +Sal, DBP50 +HFD+VitE, DBP50 +HFD+Sal). The entire experimental period lasted for 12 weeks. We assessed the effects of DBP and HFD on cardiac function using echocardiography, as well as their impact on the development of cardiac fibrosis through histopathological analysis of the heart. Additionally, we examined the histopathology of liver tissue, lipid levels (Total cholesterol, Triglycerides, High-density lipoprotein, Low-density lipoprotein, Very low-density lipoprotein, Oxidized low-density lipoprotein), oxidative stress biomarkers (Reactive oxygen species, Malondialdehyde, Glutathione), pyroptosis-related proteins (NLRP3, Caspase-1, GSDMD, Interleukin-1R, Interleukin 18), and serum metabolomics (Data Credibility Analysis, Metabolite Differential Analysis, Metabolic Pathway Analysis and Metabolism-related analysis). Results: Our findings revealed that, compared to the saline group, both the high-dose DBP group and the HFD group exhibited significant cardiotoxic effects, inducing alterations in oxidative stress markers (ROS, MDA, and GSH) and levels of pyroptosis-related proteins (NLRP3, Caspase-1, and GSDMD) in myocardial tissue. Concurrently, the high-dose DBP and HFD groups demonstrated notable endocrine-disrupting effects, triggering hepatic steatosis (H&E and Oil Red O) and hyperlipidemia (TC, TG, HDL, LDL, VLDL, and ox-LDL). Ultimately, the combined action of DBP and HFD exacerbated the progression of cardiac fibrosis (H&E and Masson) and dysfunction (Echocardiography). Furthermore, metabolomics results suggest that the relevant pathways and metabolites involved in the citrate cycle (TCA cycle), arginine biosynthesis, tryptophan metabolism, and linoleic acid metabolism may also play significant roles. However, intervention with the inhibitors vitamin E and salidroside demonstrated protective effects against these adverse outcomes.
   Notably, salidroside exhibited superior efficacy compared to vitamin E in ameliorating lipid metabolism disorders, indicating its potential for preventing and treating cardiac fibrosis and dysfunction exacerbated by the synergistic effects of DBP and HFD. Conclusion: This study reveals, for the first time, the synergistic effect of DBP on HFD-induced cardiac fibrosis and dysfunction, suggesting that salidroside has a protective effect against cardiac fibrosis. These findings provide new insights into the multifaceted mechanisms involved in the pathology of cardiac fibrosis induced by DBP and HFD, and offer potential intervention targets for the prevention and treatment of cardiac fibrosis and dysfunction exacerbated by the synergistic effects of DBP and HFD.
C1 [Liang, Xiao; Wu, Yang; Feng, Qing; Zhu, Deyu; Huang, Qi; Wei, Zhuangzhuang; Ma, Ping; Yang, Xu; Bao, Cuiyu; Bao, Xinyu] Hubei Univ Sci & Technol, Xianning Med Coll, Key Lab Environm Related Dis & One Hlth, Xianning 437100, Peoples R China.
   [Liang, Xiao; Bao, Xinyu] Hubei Univ Sci & Technol, Sch Publ Hlth & Nursing, Xianning 437100, Peoples R China.
   [Yang, Xu] Dali Univ, Inst Nat Antioxidants & Antioxidant Inflammat, Dali 671003, Peoples R China.
C3 Hubei University of Science & Technology; Hubei University of Science &
   Technology; Dali University
RP Bao, XY (corresponding author), Univ Sci & Technol, 88 Xianning Ave, Xianning 437100, Peoples R China.
EM bcy@hbust.edu.cn
FU National Natural Science Foundation of China [42177416, 42477452]; Hubei
   Provincial Natural Science Foundation and Xianning-of China
   [2025AFD389]; Key Special Project for Social Development R & D of
   Xianning City Science and Technology Program [2023SFYF095]; Scientific
   Research Innovative Team of Hubei University of Science and Technology
   [2023T08]
FX This work was supported by the National Natural Science Foundation of
   China (42177416, 42477452) , Joint supported by Hubei Provincial Natural
   Science Foundation and Xianning-of China (2025AFD389) , Key Special
   Project for Social Development R & D of Xianning City Science and
   Technology Program (2023SFYF095) , and Scientific Research Innovative
   Team of Hubei University of Science and Technology (2023T08) .
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NR 80
TC 3
Z9 3
U1 13
U2 18
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD SEP 1
PY 2025
VL 302
AR 118708
DI 10.1016/j.ecoenv.2025.118708
EA JUL 2025
PG 18
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA 6JD6I
UT WOS:001554608000003
PM 40684633
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Cheng, S
   Xin, JL
   Zhang, TR
   Zhang, YL
   Ji, CX
   Kang, LL
   Zhu, XY
   Zhang, H
   Wang, W
   Liao, XF
AF Cheng, Sheng
   Xin, Jialiang
   Zhang, Tianran
   Zhang, Yulin
   Ji, Chengxi
   Kang, Lulu
   Zhu, Xiangyu
   Zhang, He
   Wang, Wei
   Liao, Xinfei
TI Assessing the potential impact of salidroside on Chikungunya
   virus-induced acute interstitial nephritis via network pharmacology,
   molecular docking and in vitro experiments
SO FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
LA English
DT Article
DE CHIKV; salidroside; network pharmacology; molecular docking;
   ferroptosis; apoptosis
ID EPIDEMIOLOGY; REPLICATION; DISEASE; FEVER
AB Chikungunya virus (CHIKV) infection is often linked to acute interstitial nephritis (AIN) in fatal cases. Given the global spread of CHIKV and the lack of targeted antiviral treatments, there is an urgent need for effective therapeutic strategies against CHIKV-induced AIN. This study explored the therapeutic potential of salidroside (Sal) using an integrative approach involving network pharmacology, molecular docking and in vitro validation. Network pharmacology analysis identified 18 overlapping targets between Sal and AIN, including TNF, IL6 and AKT1. Molecular docking revealed strong binding affinities between Sal and key pathway proteins (Vina scores < -6), notably TNF, IL6 and BCL2. In vitro assays using CHIKV-infected 293T cells demonstrated that Sal (7.8125-2000 mu M) enhanced cell viability by 8.9-25.9%, with the greatest effect observed at 1000 mu M, without significantly altering viral replication. Mechanism analysis using the KEGG and FerrDB databases implicated apoptosis and ferroptosis in CHIKV-induced AIN pathogenesis. RT-qPCR analysis confirmed that Sal significantly downregulated ferroptosis-related genes (IL-6, IL-1 beta, SIRT1, PARP1, HMOX1) and apoptosis-associated markers (Bax, TNF-alpha, PARP1) in infected cells. Consistent with these findings, molecular docking demonstrated that Sal binds strongly to the ferroptosis-related protein GPX4 (Vina score: -6.3) and the apoptosis regulator NFKB1 (Vina score: -6.0). These results suggest that Sal is a promising therapeutic candidate for the treatment of CHIKV-induced AIN.
C1 [Cheng, Sheng; Xin, Jialiang] Sichuan Agr Univ, Coll Vet Med, Key Lab Anim Dis & Human Hlth Sichuan Prov, Chengdu, Peoples R China.
   [Xin, Jialiang; Zhang, Yulin; Ji, Chengxi; Kang, Lulu; Zhu, Xiangyu; Wang, Wei] Wenzhou Univ, Inst Virol, Humanities Lab Ecol Civilizat & Environm Governanc, Wenzhou, Peoples R China.
   [Xin, Jialiang; Zhang, Yulin; Ji, Chengxi; Kang, Lulu; Zhang, He; Wang, Wei] Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun, Peoples R China.
   [Zhang, Tianran] Wenzhou Municipal Ctr Dis Control & Prevent, Wenzhou Municipal Inst Hlth Supervis, Wenzhou, Peoples R China.
   [Liao, Xinfei] Wenzhou Polytech, Wenzhou, Peoples R China.
C3 Sichuan Agricultural University; Key Laboratory of Animal Disease &
   Human Health of Sichuan Province; Wenzhou University; Chinese Academy of
   Agricultural Sciences; Wenzhou Polytechnic
RP Zhu, XY; Wang, W (corresponding author), Wenzhou Univ, Inst Virol, Humanities Lab Ecol Civilizat & Environm Governanc, Wenzhou, Peoples R China.; Zhang, H; Wang, W (corresponding author), Chinese Acad Agr Sci, Changchun Vet Res Inst, Changchun, Peoples R China.; Liao, XF (corresponding author), Wenzhou Polytech, Wenzhou, Peoples R China.
EM zhuxiangyu00@126.com; hezhangvs@126.com; wwky1101@126.com;
   xinfei_liao@126.com
RI Zhu, Xiangyu/NBY-2483-2025
OI Zhu, Xiangyu/0009-0003-0203-0342; Zhang, Tianran/0009-0005-5376-472X
FU Wenzhou Scientific Research Project [S20240001]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. This work was supported by
   the Wenzhou Scientific Research Project (S20240001).
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NR 23
TC 6
Z9 6
U1 10
U2 14
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 2235-2988
J9 FRONT CELL INFECT MI
JI Front. Cell. Infect. Microbiol.
PD JUL 22
PY 2025
VL 15
AR 1623860
DI 10.3389/fcimb.2025.1623860
PG 8
WC Immunology; Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Microbiology
GA 5UD4C
UT WOS:001544394400001
PM 40766840
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zheng, KS
   Yang, CW
   Han, MM
   Kang, F
   Li, J
AF Zheng, Kesong
   Yang, Chengwei
   Han, Mingming
   Kang, Fang
   Li, Juan
TI Salidroside alleviates bone cancer pain by inhibiting Th17/Treg
   imbalance through the AMPK/SIRT1 pathway
SO PHYTOMEDICINE
LA English
DT Article
DE Bone cancer pain; Salidroside; Th17; Treg; AMPK/SIRT1 signal pathway
ID SPINAL-CORD; ACTIVATION; SIRTUIN-1
AB Background Bone cancer pain (BCP) remains a significant clinical challenge with poorly understood mechanisms. While Th17 and Treg cells have been implicated in pain pathways, their specific roles in BCP pathogenesis require further investigation. Salidroside (SAL), a natural compound with anti-inflammatory properties, shows potential for pain management but its mechanism in BCP is unclear. Purpose This study aimed to investigate SAL's analgesic effects in BCP and elucidate its mechanism of action through the AMPK/SIRT1 pathway and Th17/Treg cell regulation. Study design Experimental animal study using a well-established BCP mouse model with pharmacological interventions and cellular/molecular analyses. Methods C57BL/6 mice were used to establish a BCP model via tumor cell implantation. Behavioral tests assessed mechanical allodynia and thermal hyperalgesia. Flow cytometry analyzed spinal cord Th17/Treg populations, while Western blotting evaluated AMPK/SIRT1 pathway proteins. Pharmacological interventions included SAL administration, IL-17 neutralization, and AMPK/SIRT1 pathway modulation. Results SAL treatment significantly alleviated pain behaviors in BCP mice (p < 0.01). Cellular analyses revealed SAL restored Th17/Treg balance by reducing Th17 markers (IL-17, ROR gamma t, p-STAT3) and increasing Treg markers (FOXP3, p-STAT5). SAL activated the AMPK/SIRT1 pathway, while pathway inhibitors reversed SAL's therapeutic effects, confirming the mechanism. Conclusion SAL effectively alleviates BCP by modulating Th17/Treg cell differentiation through AMPK/SIRT1 pathway activation. These findings suggest SAL's potential as a novel immunomodulatory therapy for BCP management.
C1 [Zheng, Kesong] Shandong Univ, Cheeloo Coll Med, Jinan, Shandong Provin, Peoples R China.
   [Zheng, Kesong; Yang, Chengwei; Han, Mingming; Kang, Fang; Li, Juan] Univ Sci & Technol China, Affiliated Hosp USTC 1, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China.
C3 Shandong University; Chinese Academy of Sciences; University of Science
   & Technology of China, CAS
RP Li, J (corresponding author), Univ Sci & Technol China, Affiliated Hosp USTC 1, Div Life Sci & Med, Hefei 230001, Anhui, Peoples R China.
EM huamuzi1999@163.com
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NR 35
TC 3
Z9 4
U1 3
U2 7
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD SEP
PY 2025
VL 145
AR 157000
DI 10.1016/j.phymed.2025.157000
EA JUL 2025
PG 13
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 4UL7G
UT WOS:001526947900001
PM 40609386
DA 2026-05-27
ER

PT J
AU Yan, TX
   Li, X
   Wang, X
   He, BS
   Jia, Y
   Xiao, W
AF Yan, Tingxu
   Li, Xu
   Wang, Xin
   He, Bosai
   Jia, Ying
   Xiao, Wei
TI Salidroside Alleviates Myocardial Ischemia Reperfusion by Balancing
   Mitochondrial Homeostasis via Nrf2
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article
ID DYSFUNCTION; MECHANISMS; AUTOPHAGY; DYNAMICS
AB Salidroside (SAL), a phenylpropanoid glycoside compound mainly from Rhodiola rosea, showed potential effects on myocardial ischemia reperfusion (MIRI) in our previous studies. The primary objective of this investigation was to study the mechanism by which SAL preserves mitochondrial homeostasis in order to provide protection against MIRI. The impact of SAL on the hypoxia/reoxygenation (H/R)-induced H9c2 cells was detected by using CCK-8, LDH, and AST. The number, function, and morphology of mitochondria were examined by TEM, RT-qPCR, and western blot. The binding ability between SAL and Nrf2 was explored through molecular docking and the cell thermal shift assay. Combined with the Nrf2 inhibitor ML385, our results demonstrated that SAL promotes mitochondrial protection by activating Nrf2, decreasing oxidative stress, and altering the AMPK/PGC-1 alpha/PPAR alpha pathway. In addition, SAL elevates ATP levels and improves mitochondrial dynamics imbalance by inducing both autophagy and mitophagy. These findings highlight the potential therapeutic benefits of SAL for cardiac health and the mitigation of MIRI.
C1 [Yan, Tingxu; Li, Xu; Wang, Xin; Xiao, Wei] Jiangsu Kan Pharmaceut Co Ltd, Lianyungang 222047, Peoples R China.
   [Yan, Tingxu; He, Bosai; Jia, Ying] Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Wenhua Rd 103, Shenyang 110016, Peoples R China.
C3 Shenyang Pharmaceutical University
RP Xiao, W (corresponding author), Jiangsu Kan Pharmaceut Co Ltd, Lianyungang 222047, Peoples R China.; Jia, Y (corresponding author), Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Wenhua Rd 103, Shenyang 110016, Peoples R China.
EM ytxsyphu@163.com; lixu19900611@163.com; 793796283@qq.com;
   hbspharma@163.com; jysyphu@163.com; xw_kanion@163.com
RI He, Bosai/OML-7628-2025; xiao, wei/KCK-6954-2024
OI He, Bosai/0000-0003-0956-9546; 
FU Special Funds for Transformation and Upgrading of Industrial
   Informatization of Industry and Information Technology Department of
   Jiangsu (2020): Key Technologies of Multi-Component Traditional Chinese
   Medicines; Special Funds for Transformation and Upgrading of Industrial
   Informatization of Industry and Information Technology Department of
   Jiangsu; Key Technologies of Multi-Component Traditional Chinese
   Medicines [82173961]; National Natural Science Foundation of China
FX This research was supported by Special Funds for Transformation and
   Upgrading of Industrial Informatization of Industry and Information
   Technology Department of Jiangsu (2020): Key Technologies of
   Multi-Component Traditional Chinese Medicines and the National Natural
   Science Foundation of China (No. 82173961).
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NR 44
TC 2
Z9 2
U1 2
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD FEB 14
PY 2024
VL 2024
AR 9971510
DI 10.1155/2024/9971510
PG 15
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA IU2W7
UT WOS:001168795100001
OA hybrid
DA 2026-05-27
ER

PT J
AU Ma, YC
   Wang, XQ
   Hou, FF
   Ma, J
   Luo, M
   Lu, S
   Jin, P
   Terevsky, N
   Chen, A
   Xu, I
   Patel, AV
   Gorecki, D
AF Ma, Yuan-Chun
   Wang, Xiao-Qiang
   Hou, Fei Fei
   Ma, Jie
   Luo, Mai
   Lu, Shane
   Jin, Peter
   Terevsky, Nelly
   Chen, Alice
   Xu, Iris
   Patel, Asmita V.
   Gorecki, Dariusz
TI Rapid Resolution Liquid Chromatography (RRLC) Analysis for Quality
   Control of Rhodiola rosea Roots and Commercial Standardized
   Products
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Article
DE Rhodiola rosea L.; rapid resolution liquid chromatography (RRLC); HPLC
   profile; salidroside; rosavin; rosavin
ID IDENTIFICATION; FLAVONOIDS; L.
AB A simple, sensitive and reliable reversed phase Rapid Resolution Liquid Chromatography (RRLC) method was developed and validated for six biologically active compounds (salidroside, tyrosol, rosarin, rosavin, rosin and rosiridin) in Rhodiola rosea L. roots and powder extracts. The method uses a Phenomenex C18 (2)-HST column at 40 degrees C with a neutral gradient system mobile phase (H2O and acetonitrile), a flow rate of 1.0 mL/min, and UV detection wavelengths set at 205 and 254 run, simultaneously. Baseline separation of the six active compounds was achieved within 8 minutes. The average percentages of rosavins (rosarin, rosavin, and rosin) in authentic R. rosea roots and root powder extracts were quantitatively determined and a characteristic R. rosea roots RRLC profile was established. The RRLC method is accurate and sensitive; in addition, it effectively increases the sample analysis throughput compared with conventional HPLC.
C1 [Ma, Yuan-Chun; Wang, Xiao-Qiang; Hou, Fei Fei; Ma, Jie; Luo, Mai; Lu, Shane; Jin, Peter; Terevsky, Nelly; Chen, Alice; Xu, Iris] Canadian Phytopharmaceut Corp, Richmond, BC V6W 1K8, Canada.
   [Ma, Yuan-Chun; Wang, Xiao-Qiang; Ma, Jie] Canadian Inst Med Plants, Richmond, BC V6W 1K8, Canada.
   [Ma, Jie; Patel, Asmita V.; Gorecki, Dariusz] Univ Portsmouth, Sch Pharm & Biomed Sci, Portsmouth PO1 2DT, Hants, England.
C3 University of Portsmouth
RP Ma, J (corresponding author), Canadian Phytopharmaceut Corp, 12233 Riverside Way, Richmond, BC V6W 1K8, Canada.
EM jiem@canphyto.com
OI Gorecki, Dariusz/0000-0003-3584-1654; Sautreau, Asmita
   Vithaldas/0000-0002-0376-8643
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NR 22
TC 18
Z9 18
U1 0
U2 23
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD MAY
PY 2011
VL 6
IS 5
BP 645
EP 650
PG 6
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA 762UF
UT WOS:000290506200019
PM 21615025
DA 2026-05-27
ER

PT J
AU Cheng, SH
   Meng, XY
   Wang, ZX
   Lan, TF
   Zhou, Z
   Wang, ZH
   Abliz, Z
AF Cheng, Shuohan
   Meng, Xianyue
   Wang, Zixuan
   Lan, Tianfang
   Zhou, Zhi
   Wang, Zhonghua
   Abliz, Zeper
TI Mass Spectrometry Imaging Reveals Spatial Metabolic Alterations and
   Salidroside's Effects in Diabetic Encephalopathy
SO METABOLITES
LA English
DT Article
DE mass spectrometry imaging; diabetic encephalopathy; AFADESI-MSI;
   salidroside; metabolic alterations
ID BRAIN; CARNITINE; GLUTAMATE; GABA
AB Background: Diabetic encephalopathy (DE) is a neurological complication of diabetes marked by cognitive decline and complex metabolic disturbances. Salidroside (SAL), a natural compound with antioxidant and neuroprotective properties, has shown promise in alleviating diabetic complications. Exploring the spatial metabolic reprogramming in DE and elucidating SAL's metabolic effects are critical for deepening our understanding of its pathogenesis and developing effective therapeutic strategies. Methods: Air-flow-assisted desorption electrospray ionization-mass spectrometry imaging (AFADESI-MSI) was employed to investigate spatial metabolic alterations in the brains of db/db mice, a spontaneous DE model. The mice were treated with SAL (30 and 150 mg/kg, orally) for 12 weeks. Differential metabolites were identified and characterized using high-resolution mass spectrometry and validated against public databases. Results: Our AFADESI-MSI analysis revealed significant changes in 26 metabolites in the brains of DE mice compared to the controls. These metabolic changes indicated disruptions in glucose, glutamate-glutamine, nucleotide, lipid, choline, aspartate, and L-carnitine metabolism. Notably, glucose 6-phosphate (G6P), glutamine, adenosine, L-carnitine, and choline exhibited similar trends in both db/db mice and STZ-induced rat models of DE, suggesting their potential as reliable biomarkers. Twelve weeks of SAL treatment demonstrated a positive regulatory effect on glucose metabolism, the glutamate-glutamine cycle, and lipid metabolism. Conclusions: This study identifies key metabolic alterations in DE and demonstrates the therapeutic potential of SAL in modulating these disturbances, offering valuable insights for targeted interventions in diabetic complications.
C1 [Cheng, Shuohan; Meng, Xianyue; Wang, Zixuan; Lan, Tianfang; Zhou, Zhi; Wang, Zhonghua; Abliz, Zeper] Minzu Univ China, Key Lab Mass Spectrometry Imaging & Metabol, Natl Ethn Affairs Commiss, Beijing 100081, Peoples R China.
   [Cheng, Shuohan; Abliz, Zeper] Minzu Univ China, Sch Pharm, Key Lab Ethnomed, Minist Educ, Beijing 100081, Peoples R China.
   [Meng, Xianyue; Wang, Zixuan; Lan, Tianfang; Zhou, Zhi; Wang, Zhonghua; Abliz, Zeper] Minzu Univ China, Coll Life & Environm Sci, Ctr Imaging & Syst Biol, 27 Zhongguancun South Ave, Beijing 100081, Peoples R China.
C3 Ministry of Education - China
RP Wang, ZH (corresponding author), Minzu Univ China, Key Lab Mass Spectrometry Imaging & Metabol, Natl Ethn Affairs Commiss, Beijing 100081, Peoples R China.; Wang, ZH (corresponding author), Minzu Univ China, Coll Life & Environm Sci, Ctr Imaging & Syst Biol, 27 Zhongguancun South Ave, Beijing 100081, Peoples R China.
EM shuohan_cheng@163.com; massi6893@163.com; wangzixuan1874@163.com;
   23302551@muc.edu.cn; zhouzhi@muc.edu.cn; wangzhonghua@muc.edu.cn;
   zeper@muc.edu.cn
RI Cheng, Shuohan/OJU-2120-2025
FU National Natural Science Foundation of China; National Key Research and
   Development Program of China [2023YFC3504401];  [21927808]
FX This study was funded by the National Natural Science Foundation of
   China (21927808) and the National Key Research and Development Program
   of China (no. 2023YFC3504401).
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NR 52
TC 2
Z9 2
U1 3
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2218-1989
J9 METABOLITES
JI Metabolites
PD DEC
PY 2024
VL 14
IS 12
AR 670
DI 10.3390/metabo14120670
PG 15
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA Q5A7M
UT WOS:001384812800001
PM 39728451
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, XH
   Liu, YM
   Shan, H
   Tan, JF
   Zhou, J
   Song, YJ
   Li, SQ
   Liu, C
   Xu, DQ
   Yu, L
   Li, WW
AF Li, Xiao Hong
   Liu, Yu Mei
   Shan, Hui
   Tan, Jin Feng
   Zhou, Jian
   Song, Yuan Jin
   Li, Si Qi
   Liu, Chen
   Xu, Dong Qun
   Yu, Li
   Li, Wan Wei
TI Salidroside Ameliorates Lung Injury Induced by PM2.5 by
   Regulating SIRT1-PGC-1α in Mice
SO BIOMEDICAL AND ENVIRONMENTAL SCIENCES
LA English
DT Article
DE PM 2.5; Salidroside; Oxidative stress; Inflammation; Apoptosis;
   SIRT1-PGC-1 alpha
ID AIR-POLLUTION; EXPOSURE; ACTIVATION; APOPTOSIS; PROTECTS; PATHWAY;
   STRESS; CELLS
AB Objective This study aimed to clarify the intervention effect of salidroside (SAL) on lung injury caused by PM2.5 in mice and illuminate the function of SIRT1-PGC-1 alpha axis. Methods Specific pathogen-free (SPF) grade male C57BL/6 mice were randomly assigned to the following groups: control group, SAL group, PM2.5 group, SAL+PM2.5 group. On the first day, SAL was given by gavage, and on the second day, PM2.5 suspension was given by intratracheal instillation. The whole experiment consist of a total of 10 cycles, lasting 20 days. At the end of treatment, blood samples and lung tissues were collected and analyzed. Observation of pathological changes in lung tissue using inverted microscopy and transmission electron microscopy. The expression of inflammatory, antioxidants, apoptosis, and SIRT1-PGC-1 alpha proteins were detected by Western blotting. Results Exposure to PM2.5 leads to obvious morphological and pathologica changes in the lung of mice. PM2.5 caused a decline in levels of antioxidant-related enzymes and protein expressions of HO-1, Nrf2, SOD2, SIRT1 and PGC-1 alpha, and an increase in the protein expressions of IL-6, IL-1 beta, Bax, caspase-9 and cleaved caspase-3. However, SAL reversed the aforementioned changes caused by PM2.5 by activating the SIRT1-PGC-1 alpha pathway. Conclusion SAL can activate SIRT1-PGC-1 alpha to ameliorate PM2.5-induced lung injury.
C1 [Li, Xiao Hong; Liu, Yu Mei; Shan, Hui; Zhou, Jian; Li, Si Qi; Liu, Chen; Li, Wan Wei] Shandong Second Med Univ, Sch Publ Hlth, Weifang 261053, Shandong, Peoples R China.
   [Li, Xiao Hong; Liu, Yu Mei; Li, Wan Wei] Key Lab Hlth Inspect & Quarantine, Weifang 261053, Shandong, Peoples R China.
   [Tan, Jin Feng] Weifang Environm Monitoring Stn, Weifang 261042, Shandong, Peoples R China.
   [Song, Yuan Jin] 80th Army Hosp PLA, Dept Orthoped, Weifang 261000, Shandong, Peoples R China.
   [Xu, Dong Qun] Chinese Ctr Dis Control & Prevent, Environm & Hlth Related Prod Safety Inst, Beijing 100021, Peoples R China.
   [Yu, Li] Shandong Second Med Univ, Sch Basic Med, Weifang 261053, Shandong, Peoples R China.
C3 Shandong Second Medical University; Chinese Center for Disease Control &
   Prevention; Shandong Second Medical University
RP Li, WW (corresponding author), Shandong Second Med Univ, Sch Publ Hlth, Weifang 261053, Shandong, Peoples R China.; Li, WW (corresponding author), Key Lab Hlth Inspect & Quarantine, Weifang 261053, Shandong, Peoples R China.
EM lilili127@163.com
FU Shandong Provincial Natural Science Foundation, China [ZR2020MH336];
   Weifang Science and Technology Development Plan Project [2022GX015,
   2022GX010]
FX * This study was supported by Shandong Provincial Natural Science
   Foundation, China (No. ZR2020MH336) ; and Weifang Science and Technology
   Development Plan Project (NO. 2022GX015, NO. 2022GX010) .
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NR 35
TC 1
Z9 4
U1 2
U2 8
PU CHINESE CENTER DISEASE CONTROL & PREVENTION
PI BEIJING
PA 155 CHANGBAI RD, CHANGPING DISTRICT, BEIJING, 102206, PEOPLES R CHINA
SN 0895-3988
EI 2214-0190
J9 BIOMED ENVIRON SCI
JI Biomed. Environ. Sci.
PD APR
PY 2024
VL 37
IS 4
BP 367
EP 376
DI 10.3967/bes2024.041
EA MAY 2024
PG 10
WC Environmental Sciences; Public, Environmental & Occupational Health
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Public, Environmental & Occupational
   Health
GA YB4L6
UT WOS:001266011900001
PM 38727159
DA 2026-05-27
ER

PT J
AU Chai, YH
   Cai, YW
   Fu, Y
   Wang, YD
   Zhang, YM
   Zhang, X
   Zhu, LP
   Miao, MX
   Yan, TH
AF Chai, Yuhui
   Cai, Yawen
   Fu, Yu
   Wang, Yingdi
   Zhang, Yiming
   Zhang, Xue
   Zhu, Lingpeng
   Miao, Mingxing
   Yan, Tianhua
TI Salidroside Ameliorates Depression by Suppressing NLRP3-Mediated
   Pyroptosis via P2X7/NF-κB/NLRP3 Signaling Pathway
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; depression; pyroptosis; NLRP3
ID NF-KAPPA-B; MILD STRESS MODEL; NLRP3 INFLAMMASOME; PARKINSONS-DISEASE;
   ISCHEMIC-STROKE; P2X7 RECEPTOR; MOUSE MODEL; CELL-DEATH; RAT MODEL;
   ACTIVATION
AB Depression is a common and serious mental disorder. Data on its pathogenesis remain unclear and the options of drug treatments are limited. Here, we explored the role of pyroptosis, a novel pro-inflammatory programmed cell death process, in depression as well as the anti-depression effects and mechanisms of salidroside (Sal), a bioactive extract from Rhodiola rosea L. We established a corticosterone (CORT)-induced or lipopolysaccharide (LPS)-induced mice in vivo, and CORT, or nigericin (NLRP3 agonist)-induced PC12 cells in vitro. Our findings demonstrated that Sal profoundly mediated CORT or LPS-induced depressive behavior and improved synaptic plasticity by upregulating the expression of brain-derived neurotrophic factor (BDNF) gene. The data showed upregulation of proteins associated with NLRP3-mediated pyroptosis, including NLRP3, cleaved Caspase-1, IL-1 beta, IL-18, and cleaved GSDMD. The molecular docking simulation predicted that Sal would interact with P2X7 of the P2X7/NF-kappa B/NLRP3 signaling pathway. In addition, our findings showed that the NLRP3-mediated pyroptosis was regulated by P2X7/NF-kappa B/NLRP3 signaling pathway. Interestingly, Sal was shown to ameliorate depression via suppression of the P2X7/NF-kappa B/NLRP3 mediated pyroptosis, and rescued nigericin-induced pyroptosis in the PC12 cells. Besides, knock down of the NLRP3 gene by siRNA markedly increased the inhibitory effects of Sal on pyroptosis and proinflammatory responses. Taken together, our findings demonstrated that pyroptosis plays a crucial role in depression, and Sal ameliorates depression by suppressing the P2X7/NF-kappa B/NLRP3-mediated pyroptosis. Thus, our study provides new insights into the potential treatment options for depression.
C1 [Chai, Yuhui; Cai, Yawen; Fu, Yu; Wang, Yingdi; Zhang, Yiming; Zhang, Xue; Yan, Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Peoples R China.
   [Zhu, Lingpeng] Nanjing Med Univ, Ctr Clin Res, Affiliated Wuxi Peoples Hosp, Wuxi, Jiangsu, Peoples R China.
   [Miao, Mingxing] China Pharmaceut Univ, Ctr Natl Pharmaceut Expt Teaching Demonstrat, Nanjing, Peoples R China.
C3 China Pharmaceutical University; Nanjing Medical University; China
   Pharmaceutical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Peoples R China.; Zhu, LP (corresponding author), Nanjing Med Univ, Ctr Clin Res, Affiliated Wuxi Peoples Hosp, Wuxi, Jiangsu, Peoples R China.; Miao, MX (corresponding author), China Pharmaceut Univ, Ctr Natl Pharmaceut Expt Teaching Demonstrat, Nanjing, Peoples R China.
EM zhulingpeng@njmu.edu.cn; mmx0224@163.com; 1020050806@cpu.edu.cn
RI ; Cai, Yawen/OKR-6198-2025; yingdi, Wang/OEN-1592-2025; Su,
   Tianyuan/Y-7054-2019
OI Yan, Tianhua/0000-0001-6124-8630; Zhu, Lingpeng/0000-0003-0762-4038; 
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NR 94
TC 85
Z9 99
U1 5
U2 101
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 12
PY 2022
VL 13
AR 812362
DI 10.3389/fphar.2022.812362
PG 21
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1B5JF
UT WOS:000792472300001
PM 35496273
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Niu, YN
   Zeng, Y
   Zhong, FF
   Long, SL
   Ren, DW
   Qin, X
   Liu, WJ
AF Niu, Ya-Na
   Zeng, Yan
   Zhong, Fang-Fang
   Long, Si-Li
   Ren, Dan-Wei
   Qin, Xiang
   Liu, Wen-Jun
TI Salidroside overcomes dexamethasone resistance in T-acute lymphoblastic
   leukemia cells
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE salidroside; acute lymphoblastic leukemia; dexamethasone; drug
   resistance
ID C-MYC; CANCER; AUTOPHAGY; APOPTOSIS; INHIBITION; GLUCOCORTICOIDS
AB The aim of the present study was to analyze whether the use of salidroside (SAL) could overcome dexamethasone (DEX) resistance in T-acute lymphocytic leukemia cells. The human T-ALL DEX-resistant cell line, CEM-C1 and the DEX-sensitive cell line, CEM-C7 were used in the current study. The proliferation inhibition rates in these cells, treated with SAL and DEX alone, and in combination were detected using a Cell Counting Kit-8 assay, while the morphological changes of the cells were observed using an inverted microscope. Reverse transcription-quantitative PCR was used to detect the mRNA expression levels of the c-Myc and LC3 genes, while flow cytometry was used to detect the cell cycle distribution and the rate of apoptosis. In addition, western blot analysis was used to detect the protein expression levels of c-Myc, BCL-2, Bax, cleaved PARP and LC3. and acridine orange staining was used to detect the changes in acidic autophagy vesicles. It was found that SAL could effectively inhibit cell proliferation and induce apoptosis in the CEM-C1 and CEM-C7 cells. In addition, SAL promoted the induction of autophagy. The protein expression levels of c-Myc in the CEM-C1 cells were significantly higher compared with that in the CEM-C7 cells. SAL downregulated the mRNA expression levels of the c-Myc gene and protein in a dose-dependent manner. This suggested that SAL could inhibit the proliferation of the CEM-C1 and CEM-C7 cells, induce apoptosis and autophagy and overcome DEX resistance in the CEM-C1 cells. The mechanism may be associated with the downregulation of c-Myc.
C1 [Niu, Ya-Na; Zeng, Yan; Zhong, Fang-Fang; Long, Si-Li; Ren, Dan-Wei; Qin, Xiang; Liu, Wen-Jun] Southwest Med Univ, Affiliated Hosp, Dept Pediat Hematol, 25 Taiping St, Luzhou 646000, Sichuan, Peoples R China.
   [Liu, Wen-Jun] Birth Defects Clin Med Res Ctr Sichuan Prov, 25 Taiping St, Luzhou 646000, Sichuan, Peoples R China.
C3 Southwest Medical University
RP Liu, WJ (corresponding author), Southwest Med Univ, Affiliated Hosp, Dept Pediat Hematol, 25 Taiping St, Luzhou 646000, Sichuan, Peoples R China.; Liu, WJ (corresponding author), Birth Defects Clin Med Res Ctr Sichuan Prov, 25 Taiping St, Luzhou 646000, Sichuan, Peoples R China.
EM liuwenjun_1@163.com
RI Zeng, Yan/HMP-0997-2023; Liu, Wen-Jun/AED-1828-2022
OI Liu, Wen-Jun/0000-0002-7205-0598
FU Basic Research Project of Sichuan Province [2019YJ0690]; Luzhou Science
   and Technology Plan Project [2019-RCW-96, 2019-RCM-98]; Major Science
   and Technology Projects in Sichuan Province [2019YFS0531]
FX This study was supported by the Basic Research Project of Sichuan
   Province (grant no. 2019YJ0690), Luzhou Science and Technology Plan
   Project (grant nos. 2019-RCW-96 and 2019-RCM-98) and the Major Science
   and Technology Projects in Sichuan Province (grant no. 2019YFS0531).
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NR 53
TC 3
Z9 3
U1 0
U2 11
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JUN
PY 2021
VL 21
IS 6
AR 636
DI 10.3892/etm.2021.10068
PG 13
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA RZ4LT
UT WOS:000648569400001
PM 33968167
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Guo, QY
   Yang, J
   Chen, YM
   Jin, X
   Li, ZM
   Wen, XC
   Xia, Q
   Wang, Y
AF Guo, Qiaoyun
   Yang, Jing
   Chen, Yumeng
   Jin, Xin
   Li, Zongmin
   Wen, Xiaochang
   Xia, Qun
   Wang, Yue
TI Salidroside improves angiogenesis-osteogenesis coupling by regulating
   the HIF-1α/VEGF signalling pathway in the bone environment
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Salidroside; Angiogenesis; Osteogenesis; Endothelial cells;
   Hypoxia-inducible factor-1 alpha (HIF-1 alpha); Vascular endothelial
   growth factor (VEGF)
ID HYPOXIA-INDUCIBLE FACTOR; OSTEOBLAST; VEGF; ACTIVATION; MODEL
AB Angiogenesis is essential for bone formation during skeletal development. HIF-1 alpha and the HIF-responsive gene VEGF (vascular endothelial growth factor) are reported to be a key mechanism for coupling osteogenesis and angiogenesis. Salidroside (SAL), a major biologically active compound of Rhodiola rosea L., possesses diverse pharmacological effects. However, whether SAL can protect against bone loss via the HIF-1 alpha/VEGF pathway, specifically by inducing angiogenesis-osteogenesis coupling in vivo, remains unknown. Therefore, in the present study, we employed primary human umbilical vein endothelial cells (HUVECs) and the permanent EA.hy926 human endothelial cell line to determine the cellular and molecular effects of SAL on vascular endothelial cells and the HIF-1 alpha-VEGF signalling pathway in the coupling of angiogenesis-osteogenesis. The in vitro study revealed that the HUVECs and EA.hy926 cells treated with conditioned medium from osteoblast cells (MG-63 cells) treated with SAL or treated directly with SAL showed enhanced proliferation, migration and capillary structure formation. However, supplementation with an anti-VEGF antibody during the treatment of endothelial cells (ECs) significantly reversed the pro-angiogenic effect of SAL. Moreover, SAL upregulated HIF-1 alpha expression and increased its transcriptional activity, consequently upregulating VEGF expression at the mRNA and protein levels. In addition, our in vivo analysis demonstrated that SAL can stimulate endothelial sprouting from metatarsal bones. Thus, our mechanistic study demonstrated that the pro-angiogenic effects of SAL involve HIF-1 alpha-VEGF signalling by coordinating the coupling of angiogenesis-osteogenesis in the bone environment. Therefore, we have discovered an ideal molecule that simultaneously enhances angiogenesis and osteogenesis and thereby accelerates bone healing.
C1 [Guo, Qiaoyun; Wang, Yue] Tianjin Univ Tradit Chinese Med, Sch Integrat Med, 10 Poyang Lake Rd, Tianjin 301617, Peoples R China.
   [Guo, Qiaoyun; Yang, Jing; Li, Zongmin; Wen, Xiaochang; Wang, Yue] Chinese Peoples Armed Police Forces, Dept Pathogen Biol & Immunol, Logist Coll, Tianjin 300309, Peoples R China.
   [Chen, Yumeng] Tianjin Med Univ, Coll Pharm, Tianjin 300070, Peoples R China.
   [Jin, Xin] Chinese Peoples Armed Police Forces, Dept Pharmacol, Logist Coll, Tianjin 300309, Peoples R China.
   [Li, Zongmin] Chinese Peoples Armed Police Forces, Dept Clin Lab, Shanghai Crops Hosp, Shanghai, Peoples R China.
   [Xia, Qun] Chinese Peoples Armed Police Force, Dept Orthopaed, Characterist Med Ctr, 222 Chenglin Rd, Tianjin 300162, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin Medical
   University
RP Wang, Y (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Integrat Med, 10 Poyang Lake Rd, Tianjin 301617, Peoples R China.; Xia, Q (corresponding author), Chinese Peoples Armed Police Force, Dept Orthopaed, Characterist Med Ctr, 222 Chenglin Rd, Tianjin 300162, Peoples R China.
EM xiaqun6@163.com; wangyue6808@126.com
RI guo, qiaoyun/HGD-2206-2022; jin, xin/KWU-0198-2024
FU National Natural Science Foundation of China [81572852, 81273520,
   81572199]; Program of Science Foundation of Tianjin [18JCZDJC33200,
   19JCYBJC25300]; Program for Science and Technology of Logistics
   University of Chinese People's Armed Police Force [WHB202002, WHJ202013]
FX We thank Andrew L Kung (Dana-Farber Cancer Institute, USA) for providing
   pCMVh-HA-ssHIF-1 alpha and the control pCMVh-HA plasmids. This research
   was supported by grants from the National Natural Science Foundation of
   China (grant numbers 81572852, 81273520, and 81572199), the Program of
   Science Foundation of Tianjin (grant numbers 18JCZDJC33200 and
   19JCYBJC25300) and the Program for Science and Technology of Logistics
   University of Chinese People's Armed Police Force (grant numbers
   WHB202002 and WHJ202013).
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NR 39
TC 49
Z9 61
U1 1
U2 52
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD OCT 5
PY 2020
VL 884
AR 173394
DI 10.1016/j.ejphar.2020.173394
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA NR9AZ
UT WOS:000571856400005
PM 32730833
DA 2026-05-27
ER

PT J
AU Kim, KJ
   Jung, YS
   You, DM
   Lee, SH
   Lee, G
   Kwon, KB
   Kim, DO
AF Kim, Kwan Joong
   Jung, Young Sung
   You, Dong Min
   Lee, Seung Hyun
   Lee, Guemsan
   Kwon, Kang-Beom
   Kim, Dae-Ok
TI Neuroprotective effects of ethanolic extract from dry Rhodiola
   rosea L. rhizomes
SO FOOD SCIENCE AND BIOTECHNOLOGY
LA English
DT Article
DE Acetylcholinesterase; DNA barcoding; Oxidative stress; Salidroside;
   Tyrosol
AB Rhodiola rosea L. rhizome has been used as a traditional medicine to treat fatigue, depression, and cognitive dysfunction. We aimed to authenticate R. rosea L. rhizome using the DNA barcoding technique and to quantify its main compounds, total phenolics, total flavonoids, and antioxidant capacity, and then to investigate their neuroprotective effects. The sequences of internal transcribed spacer and trnH-psbA of R. rosea L. rhizomes showed a 99% identity with those of NCBI GenBank database according to BLAST searches. Analysis using reversed-phase HPLC revealed five main compounds in R. rosea L. rhizome. Rhodiola rosea L. rhizome and two bioactive compounds, salidroside and tyrosol, showed free radical scavenging activity. Rhodiola rosea L. rhizome and its identified compounds protected neuronal PC-12 cells against oxidative stress and showed moderate acetylcholinesterase inhibition. Taken together, these results suggest that R. rosea L. rhizomes with bioactives can be used as a functional ingredient with potential for neuroprotection.
   [GRAPHICS]
   .
C1 [Kim, Kwan Joong; Kim, Dae-Ok] Kyung Hee Univ, Dept Food Sci & Biotechnol, Yongin 17104, South Korea.
   [Jung, Young Sung] Korea Food Res Inst, Wonju 55365, South Korea.
   [You, Dong Min; Lee, Seung Hyun] SK Bioland Co Ltd, Food R&D Ctr, Ansan 15407, South Korea.
   [Lee, Guemsan] Wonkwang Univ, Coll Korean Med, Dept Herbol, Iksan 54538, South Korea.
   [Kwon, Kang-Beom] Wonkwang Univ, Coll Korean Med, Dept Korean Physiol, Iksan 54538, South Korea.
   [Kim, Dae-Ok] Kyung Hee Univ, Skin Biotechnol Ctr, Suwon 16229, South Korea.
C3 Kyung Hee University; Korea Food Research Institute (KFRI); Wonkwang
   University; Wonkwang University; Kyung Hee University
RP Kim, DO (corresponding author), Kyung Hee Univ, Dept Food Sci & Biotechnol, Yongin 17104, South Korea.
EM Joong@khu.ac.kr; chembio@khu.ac.kr; dongmin84@sk.com; shleel@sk.com;
   rasfin@wku.ac.kr; desson@wku.ac.kr; DOKIM05@khu.ac.kr
RI Kim, Dae-Ok/AAK-7252-2020
OI Kim, Dae-Ok/0000-0001-9262-1354
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NR 36
TC 16
Z9 21
U1 3
U2 53
PU KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
PI SEOUL
PA #605, KOREA SCI TECHNOL CENT, 635-4 YEOKSAM-DONG, KANGNAM-GU, SEOUL,
   135-703, SOUTH KOREA
SN 1226-7708
EI 2092-6456
J9 FOOD SCI BIOTECHNOL
JI Food Sci. Biotechnol.
PD FEB
PY 2021
VL 30
IS 2
BP 287
EP 297
DI 10.1007/s10068-020-00868-7
EA FEB 2021
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA QN9AN
UT WOS:000615157900001
PM 33732519
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Zhang, YJ
   Lin, F
   Yan, ZG
   Chen, ZG
   Chen, YE
   Zhao, YL
   Zhao, GA
AF Zhang, Yongjie
   Lin, Fei
   Yan, Zhigang
   Chen, Zhigang
   Chen, Yingen
   Zhao, Yilin
   Zhao, Guoan
TI Salidroside downregulates microRNA-133a and inhibits endothelial cell
   apoptosis induced by oxidized low-density lipoprotein
SO INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
LA English
DT Article
DE salidroside; oxidized low-density lipoprotein; microRNA-133a; Bcl-xL;
   endothelial cell
ID BCL-XL EXPRESSION; INDUCED INJURY; ATHEROSCLEROSIS; PROLIFERATION;
   DYSFUNCTION; PROTECTS
AB Vascular endothelial cell apoptosis is regulated by microRNA-133a (miR-133a), which participates in the formation of atherosclerotic (AS) plaques, leading to the development of several cardiovascular diseases. Salidroside (SAL), the main component of Rhodiola, is considered to exert anti-AS effect; however, its mode of action remains unclear. Thus, the present study aimed to determine whether SAL inhibits endothelial cell apoptosis through the miR-133a pathway. Cultured human coronary artery endothelial cells (HCAECs) were exposed to oxidized low-density lipoprotein (ox-LDL). Cell viability and cytotoxicity were monitored by MTT assay. In parallel, the mRNA expression levels of miR-133a and Bcl-xL, and the protein levels of anti-apoptotic Bcl-xL and activated caspase-3 were measured. The apoptotic levels were examined by flow cytometry. Furthermore, the effects of silencing and overexpressing miR-133a on the parameters mentioned above were evaluated. Exposure to ox-LDL induced an increase in the expression of miR-133a, with a concomitant decrease in the level of Bcl-xL in the HCAECs; these effects were reversed by treatment with SAL. Importantly, the effects of SAL were impaired upon the silencing of miR-133a, whereas the overexpression of miR-133a partly restored the effects of SAL. On the whole, the findings of the present study demonstrate that SAL inhibits the ox-LDL-induced upregulation of miR-133a expression, while promoting the expression of Bcl-xL, thereby preventing endothelial cell apoptosis.
C1 [Zhang, Yongjie; Lin, Fei; Yan, Zhigang; Chen, Zhigang; Chen, Yingen; Zhao, Yilin; Zhao, Guoan] Xinxiang Med Univ, Affiliated Hosp 1, Henan Engn Res Ctr Mitochondr Biomed Heart, Ctr Heart, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China.
C3 Henan Medical University
RP Zhao, GA (corresponding author), Xinxiang Med Univ, Affiliated Hosp 1, Henan Engn Res Ctr Mitochondr Biomed Heart, Ctr Heart, 88 Jiankang Rd, Xinxiang 453100, Henan, Peoples R China.
EM guoanzhao@xxmu.edu.cn
FU Foundation of Key Scientific Research Projects of Higher Education
   Institutions in Henan Province [18A320005, 19A360032]
FX The present study was supported by the Foundation of Key Scientific
   Research Projects of Higher Education Institutions in Henan Province
   (grant nos. 18A320005 and 19A360032).
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NR 49
TC 7
Z9 10
U1 1
U2 11
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1107-3756
EI 1791-244X
J9 INT J MOL MED
JI Int. J. Mol. Med.
PD OCT
PY 2020
VL 46
IS 4
BP 1433
EP 1442
DI 10.3892/ijmm.2020.4691
PG 10
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA NO3BQ
UT WOS:000569359700017
PM 32945356
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Liu, LY
   Yu, XF
   Chi, ZC
   Shi, SM
   Lan, T
   Leng, JH
   Li, JH
   He, YY
   Qu, LY
   Jia, GL
   Kong, IL
   Zhang, MJ
   Jin, YX
AF Liu, Li-Ying
   Yu, Xian-Feng
   Chi, Zhi-Chao
   Shi, Shu-Ming
   Lan, Tian
   Leng, Jia-Hui
   Li, Jing-hang
   He, Yu-Yan
   Qu, Lin-Yi
   Jia, Guan-Lin
   Kong, Ilkeun
   Zhang, Ming-Jun
   Jin, Yong-Xun
TI Salidroside improves bovine embryo quality by mitigating oxidative
   stress and regulating mitochondrial lipid metabolism
SO THERIOGENOLOGY
LA English
DT Article
DE Salidroside; Bovine embryo; Oxidative stress; Lipid metabolism;
   Mitochondria
ID PALMITOYLTRANSFERASE I GENE; FATTY-ACIDS; PPAR-ALPHA; DEVELOPMENTAL
   COMPETENCE; OOCYTE MATURATION; TRANSCRIPTION; FERTILIZATION;
   PEROXIDATION; DYSFUNCTION; DROPLETS
AB In vitro production techniques for bovine embryos can improve reproductive efficiency and expand quality breeding stock, but lipid metabolism disturbances during in vitro embryo culture can decrease embryo quality. Salidroside (SAL) is a glycoside extracted from the rhizome of the medicinal plant Rhodiola rosea that has antioxidant, antiaging, anti-inflammatory, and lipid metabolism-regulating effects. This study demonstrated that the addition of SAL to the culture medium of bovine embryos during in vitro culture increased the blastocyst rate and number of blastocyst cells and improved bovine blastocyst totipotency and proliferation. SAL reduced the lipid droplet content in bovine blastocysts and increased the levels of lipolysis-related genes (PNPLA2, LIPE, and MGLL). Fatty acids serve as ligands to activate PPAR alpha and promote the transcription and expression of downstream fatty acid beta-oxidation-related genes (CPT1A, CPT2, ACOX1, and ACOX2). SAL reduced the ROS level, increased the GSH level, increased the expression of antioxidant-related proteins (Nrf2 and downstream HO-1), and increased the levels of antioxidant enzyme-related genes (GPx1, SOD1, SOD2, and CAT) in bovine embryos. SAL increased the mitochondrial membrane potential and mitochondrial function, number, and distribution; facilitated mitochondria-lipid droplet interactions; increased fatty acid availability to mitochondria; and further enhanced fatty acid beta-oxidation. In conclusion, SAL not only acts as an antioxidant to reduce oxidative stress generated during in vitro bovine embryo culture but also promotes lipolysis to produce free fatty acids (FFA) to activate PPAR alpha, enhances fatty acid beta-oxidation, regulates lipid metabolism, and reduces the lipid content in blastocysts, thereby improving embryo developmental competence.
C1 [Liu, Li-Ying; Yu, Xian-Feng; Chi, Zhi-Chao; Shi, Shu-Ming; Lan, Tian; Leng, Jia-Hui; Li, Jing-hang; Qu, Lin-Yi; Jin, Yong-Xun] Jilin Univ, Coll Anim Sci, Jilin Prov Key Lab Anim Model, Changchun 130062, Peoples R China.
   [He, Yu-Yan; Jia, Guan-Lin; Zhang, Ming-Jun] Jilin Univ, Coll Anim Sci, Anim Genome Editing Technol Innovat Ctr, Changchun 130062, Jilin, Peoples R China.
   [Kong, Ilkeun] Gyeongsang Natl Univ, Dept Anim Sci, Div Appl Life Sci BK21 Four, Jinju 52828, South Korea.
C3 Jilin University; Jilin University; Gyeongsang National University
RP Jin, YX (corresponding author), Jilin Univ, Coll Anim Sci, Jilin Prov Key Lab Anim Model, Changchun 130062, Peoples R China.; Zhang, MJ (corresponding author), Jilin Univ, Coll Anim Sci, Anim Genome Editing Technol Innovat Ctr, Changchun 130062, Jilin, Peoples R China.
EM jyx0429@jlu.edu.cn
RI Liu, Liying/T-4397-2019
FU Earmarked fund for the Jilin Provincial Natural Science Foundation of
   China [20250205022 GH]
FX This research was funded by the earmarked fund for the Jilin Provincial
   Natural Science Foundation of China (20250205022 GH).
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NR 60
TC 1
Z9 3
U1 2
U2 10
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0093-691X
EI 1879-3231
J9 THERIOGENOLOGY
JI Theriogenology
PD NOV
PY 2025
VL 247
AR 117570
DI 10.1016/j.theriogenology.2025.117570
EA JUL 2025
PG 12
WC Reproductive Biology; Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Reproductive Biology; Veterinary Sciences
GA 5KA9N
UT WOS:001537538400001
PM 40652734
OA hybrid
DA 2026-05-27
ER

PT J
AU Chen, MH
   Liu, XZ
   Qu, XW
   Guo, RB
   Zhang, L
   Kong, L
   Yu, Y
   Liu, Y
   Zang, J
   Li, XY
   Li, XT
AF Chen, Mu-Han
   Liu, Xin-Ze
   Qu, Xiu-Wu
   Guo, Rui-Bo
   Zhang, Lu
   Kong, Liang
   Yu, Yang
   Liu, Yang
   Zang, Juan
   Li, Xiu-Ying
   Li, Xue-Tao
TI ApoE-modified liposomes encapsulating resveratrol and salidroside
   alleviate manifestations of Alzheimer's disease in APP/PS-1 mice
SO DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
LA English
DT Article
DE ApoE; resveratrol; salidroside; liposomes; blood-brain barrier;
   Alzheimer's disease
ID BLOOD-BRAIN-BARRIER; NEUROLOGICAL DISEASES; OXIDATIVE STRESS; MOUSE
   MODEL; NEUROINFLAMMATION; MICROGLIA; DELIVERY; BETA; INVOLVEMENT;
   STRATEGIES
AB ObjectiveAlzheimer's disease (AD) is a neurodegenerative disease that is associated with aging and is influenced by both genetic and environmental factors. Several studies and clinical trials have demonstrated that resveratrol (Res) and salidroside (Sal) are not only biologically safe but also influence AD biomarker trajectories. However, their clinical applications have been quite limited due to poor specificity, low solubility, and insufficient blood-brain barrier (BBB) penetration. Therefore, we developed a nano-drug delivery system in which Res and Sal were encapsulated in liposomes, which were surface-modified with ApoE (ApoE-Res/Sal-Lips) to compensate for these deficiencies.MethodIn this study, ApoE-Res/Sal-Lips were prepared using a standard thin-film hydration method for liposomes. Then, cellular uptake of the loaded liposomes was assessed in vitro using fluorescent staining assays. A BBB model was constructed to investigate the capacity of the liposomes to cross the BBB in vitro, and the ability of liposomes to target the brain was observed by in vivo imaging. In addition, the neuroprotective effects of the different liposome formulations in APP/PS-1 mice were evaluated by measuring the changes in levels of oxidative, anti-inflammatory, and anti-apoptotic factors in the mice brains.ResultsIn vitro, ApoE-Res/Sal-Lips increased the uptake of Res and Sal by bEnd.3 and N2a cells, enhanced BBB penetration, and improved transport efficiency. In vivo, the ApoE-Res/Sal-Lips were found to alleviate AD pathological symptoms, reduce learning and memory impairments, and improve brain function.ConclusionApoE-Res/Sal-Lips provide a new method for the treatment of AD.
C1 [Chen, Mu-Han; Liu, Xin-Ze; Guo, Rui-Bo; Zhang, Lu; Kong, Liang; Yu, Yang; Liu, Yang; Zang, Juan; Li, Xue-Tao] Liaoning Univ Tradit Chinese Med, Sch Pharm, Shengming 1 Rd 77, Dalian 116600, Peoples R China.
   [Qu, Xiu-Wu; Li, Xiu-Ying] Shanxi Univ Chinese Med, Shanxi Key Lab Innovat Drug Treatment Serious Dis, Jinzhong 030619, Peoples R China.
C3 Liaoning University of Traditional Chinese Medicine; Shanxi University
   of Chinese Medicine
RP Li, XT (corresponding author), Liaoning Univ Tradit Chinese Med, Sch Pharm, Shengming 1 Rd 77, Dalian 116600, Peoples R China.; Li, XY (corresponding author), Shanxi Univ Chinese Med, Shanxi Key Lab Innovat Drug Treatment Serious Dis, Jinzhong 030619, Peoples R China.
EM lixiuying@sxtcm.edu.cn; lixuetao1979@163.com
RI Li, Xuetao/AAH-2890-2020
OI Li, Xuetao/0000-0002-0608-4669
FU China Postdoctoral Science Foundation [2022MD723796]; Doctoral Startup
   Foundation of Liaoning Province [2023-BS-139]
FX China Postdoctoral Science Foundation (2022MD723796), the Doctoral
   Startup Foundation of Liaoning Province (2023-BS-139).
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PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0363-9045
EI 1520-5762
J9 DRUG DEV IND PHARM
JI Drug Dev. Ind. Pharm.
PD SEP 2
PY 2023
VL 49
IS 9
BP 559
EP 571
DI 10.1080/03639045.2023.2252062
EA SEP 2023
PG 13
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA T8FM0
UT WOS:001058202100001
PM 37649422
DA 2026-05-27
ER

PT J
AU Zhang, DQ
   Liu, XY
   Qiu, LF
   Liu, ZR
   Yang, YP
   Huang, L
   Wang, SY
   Zhang, JQ
AF Zhang, Dan-Qing
   Liu, Xiao-Ying
   Qiu, Lin-Feng
   Liu, Zhao-Rui
   Yang, Ya-Peng
   Huang, Long
   Wang, Shi-Yu
   Zhang, Jian-Qiang
TI Two chromosome-level genome assemblies of Rhodiola shed new light
   on genome evolution in rapid radiation and evolution of the biosynthetic
   pathway of salidroside
SO PLANT JOURNAL
LA English
DT Article
DE chromosome structural variation; comparative genomics; high-altitude
   adaptation; Rhodiola chrysanthemifolia; R. kirilowii; salidroside
   biosynthesis; whole-genome duplication
ID HIGH-ALTITUDE ADAPTATION; PHYLOGENETIC ANALYSIS; PLANT; ACCURATE; GENE;
   PROGRAM; ARABIDOPSIS; ALIGNMENT; DATABASE; ACID
AB Rhodiola L. is a genus that has undergone rapid radiation in the mid-Miocene and may represent a typic case of adaptive radiation. Many species of Rhodiola have also been widely used as an important adaptogen in traditional medicines for centuries. However, a lack of high-quality chromosome-level genomes hinders in-depth study of its evolution and biosynthetic pathway of secondary metabolites. Here, we assembled two chromosome-level genomes for two Rhodiola species with different chromosome number and sexual system. The assembled genome size of R. chrysanthemifolia (2n = 14; hermaphrodite) and R. kirilowii (2n = 22; dioecious) were of 402.67 and 653.62 Mb, respectively, with approximately 57.60% and 69.22% of transposable elements (TEs). The size difference between the two genomes was mostly due to proliferation of long terminal repeat-retrotransposons (LTR-RTs) in the R. kirilowii genome. Comparative genomic analysis revealed possible gene families responsible for high-altitude adaptation of Rhodiola, including a homolog of plant cysteine oxidase 2 gene of Arabidopsis thaliana (AtPCO2), which is part of the core molecular reaction to hypoxia and contributes to the stability of Group VII ethylene response factors (ERF-VII). We found extensive chromosome fusion/fission events and structural variations between the two genomes, which might have facilitated the initial rapid radiation of Rhodiola. We also identified candidate genes in the biosynthetic pathway of salidroside. Overall, our results provide important insights into genome evolution in plant rapid radiations, and possible roles of chromosome fusion/fission and structure variation played in rapid speciation.
C1 [Zhang, Dan-Qing; Liu, Xiao-Ying; Qiu, Lin-Feng; Liu, Zhao-Rui; Yang, Ya-Peng; Huang, Long; Wang, Shi-Yu; Zhang, Jian-Qiang] Shaanxi Normal Univ, Coll Life Sci, Natl Engn Lab Resource Dev Endangered Crude Drugs, Xian 710119, Peoples R China.
   [Zhang, Dan-Qing; Liu, Xiao-Ying; Qiu, Lin-Feng; Liu, Zhao-Rui; Yang, Ya-Peng; Huang, Long; Wang, Shi-Yu; Zhang, Jian-Qiang] Shaanxi Normal Univ, Key Lab Med Plant Resource & Nat Pharmaceut Chem, Minist Educ, Xian 710119, Peoples R China.
C3 Shaanxi Normal University; Shaanxi Normal University
RP Zhang, JQ (corresponding author), Shaanxi Normal Univ, Coll Life Sci, Natl Engn Lab Resource Dev Endangered Crude Drugs, Xian 710119, Peoples R China.; Zhang, JQ (corresponding author), Shaanxi Normal Univ, Key Lab Med Plant Resource & Nat Pharmaceut Chem, Minist Educ, Xian 710119, Peoples R China.
EM jqzhang@snnu.edu.cn
RI ; Qiu, Linfeng/HKF-1321-2023
OI Zhang, Jian-Qiang/0000-0003-2019-1185; 
FU We thank the editor and two anonymous reviewers for their constructive
   suggestions. We also thank Mr. Guo-Tian Zhang, Chun-Qian Ren, and Ying
   Li for their help in the field collection. This work was supported by
   the National Natural Science Foundation of C [31870194, 32070236,
   32370226]; National Natural Science Foundation of China [2023KJXX-019];
   Innovation Capability Support Program of Shaanxi [GK202301008];
   Fundamental Research Funds for the Central Universities
FX We thank the editor and two anonymous reviewers for their constructive
   suggestions. We also thank Mr. Guo-Tian Zhang, Chun-Qian Ren, and Ying
   Li for their help in the field collection. This work was supported by
   the National Natural Science Foundation of China (grant nos.: 31870194,
   32070236, 32370226), the Innovation Capability Support Program of
   Shaanxi (No. 2023KJXX-019), and the Fundamental Research Funds for the
   Central Universities (No. GK202301008 to J.Q. Zhang).
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NR 133
TC 11
Z9 12
U1 3
U2 47
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0960-7412
EI 1365-313X
J9 PLANT J
JI Plant J.
PD JAN
PY 2024
VL 117
IS 2
BP 464
EP 482
DI 10.1111/tpj.16501
EA OCT 2023
PG 19
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA GN4L1
UT WOS:001093782400001
PM 37872890
OA Bronze
DA 2026-05-27
ER

PT J
AU Jiang, SN
   Fan, FF
   Yang, L
   Chen, K
   Sun, ZH
   Zhang, Y
   Cairang, N
   Wang, XB
   Meng, XL
AF Jiang, Shengnan
   Fan, Fangfang
   Yang, Lu
   Chen, Ke
   Sun, Zhihao
   Zhang, Yi
   Cairang, Nanjia
   Wang, Xiaobo
   Meng, Xianli
TI Salidroside attenuates high altitude hypobaric hypoxia-induced brain
   injury in mice via inhibiting NF-?B/NLRP3 pathway
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Salidroside; Hypobaric hypoxia; Inflammation; NLRP3
ID ACUTE MOUNTAIN-SICKNESS; CEREBRAL EDEMA; INFLAMMATION
AB Salidroside (Sal), an active ingredient from Rhodiola crenulate, has been reported to exert neuroprotection in cerebral injury from hypobaric hypoxia (HH) at high altitude. However, it remains to be understood whether its protective effects are related to inflammation suppression. In the present work, we aimed to reveal the mechanism of Sal attenuating HH-induced brain injury in mice caused by an animal hypobaric and hypoxic chamber. Our results provided that Sal could attenuate HH-evoked pathological injury and oxidative stress response by decreasing the content of ROS and MDA, and elevating the activities of SOD and GSH-Px. Sal treatment could partly enhance the energy metabolism, evidenced by increasing the activities of Na+-K+-ATPase, Ca2+-Mg2+- ATPase, ATP, SDH, HK and PK, while decreasing the release of LDH and LD. Meanwhile, Sal administration reversed the degradation of tight junction proteins ZO-1, Occludin and Claudin-5. Further, the increased levels of TNF-alpha, IL-1 beta and IL-6 were confined with Sal administration under the HH condition. Importantly, Sal could downregulate the proteins expression of p-NF-kappa B-p65, NLRP3, cleaved-Caspase-1 and ASC. Sal also decreased the protein expression of iNOS and COX2 with the increased CD206 and Arg1 expression. Taken together, these data provided that the inhibited NF-kappa B/NLRP3 pathway by Sal could attenuate HH-induced cerebral oxidative stress injury, inflammatory responses and the blood brain barrier (BBB) damage, attributing to the improved energy metabolism and the microglial phenotype of anti-inflammatory M2. The findings suggested that Sal was expected to be a promising anti-inflammatory agent for high altitude HH-induced brain injury.
C1 [Jiang, Shengnan; Yang, Lu; Chen, Ke; Wang, Xiaobo; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Sichuan, Peoples R China.
   [Jiang, Shengnan; Yang, Lu; Chen, Ke; Wang, Xiaobo; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Res Inst Integrated TCM & Western Med, Chengdu 611137, Sichuan, Peoples R China.
   [Fan, Fangfang; Zhang, Yi] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu 611137, Sichuan, Peoples R China.
   [Sun, Zhihao] Chengdu Univ Tradit Chinese Med, Sch Basic Med, Chengdu 611137, Sichuan, Peoples R China.
   [Zhang, Yi] Chengdu Univ Tradit Chinese Med, Ethn Med Acad Heritage Innovat Res Ctr, Chengdu 611137, Sichuan, Peoples R China.
   [Cairang, Nanjia] Univ Tibetan Med, Lasa 850000, Tibet, Peoples R China.
   [Wang, Xiaobo; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine; Chengdu University of Traditional Chinese Medicine;
   Chengdu University of Traditional Chinese Medicine; Xizang University of
   Tibetan Medicine; Chengdu University of Traditional Chinese Medicine
RP Wang, XB; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu 611137, Sichuan, Peoples R China.; Wang, XB; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Res Inst Integrated TCM & Western Med, Chengdu 611137, Sichuan, Peoples R China.; Cairang, N (corresponding author), Univ Tibetan Med, Lasa 850000, Tibet, Peoples R China.; Wang, XB; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Sichuan, Peoples R China.
EM cnanjia@hotmail.com; VitaDrwang@cdutcm.edu.cn; xlm999@cdutcm.edu.cn
FU National Natural Science Foundation of China [81973569, 82104533]; China
   Postdoctoral Science Foundation [2020M683273]; Science & Technology
   Department of Sichuan Province [2021YJ0175, 2020YFQ0032]; Technology
   Project of Sichuan Science and Technology Department [2019YFSY0046];
   National Key R&D Program of China [2017YFC1703904]; Key R&D and
   Transformation Program of the Science & Technology Department of Qinghai
   Province [2020-SF-C33]; Jiayi Sun at Innovative Institute of Chinese
   Medicine and Pharmacy, Chengdu University of Traditional Chinese
   Medicine; Research Project of Doctoral Program of Traditional Chinese
   Medicine of University of Tibetan Medicine [BSDJS-20-02]
FX This work was supported by the National Natural Science Foundation of
   China (81973569 and 82104533) , the China Postdoctoral Science
   Foundation (2020M683273) , the Science & Technology Department of
   Sichuan Province (2021YJ0175) , the Major Science and Technology Project
   of Sichuan Science and Technology Department (2019YFSY0046) , the
   National Key R & D Program of China (2017YFC1703904) , the Regional
   Innovation and Cooperation Project of the Science & Technology
   Department of Sichuan Province (2020YFQ0032) , the Key R & D and
   Transformation Program of the Science & Technology Department of Qinghai
   Province (2020-SF-C33) , and the Research Project of Doctoral Program of
   Traditional Chinese Medicine of University of Tibetan Medicine
   (BSDJS-20-02) . We also expressour great appreciation to Jiayi Sun at
   Innovative Institute of Chinese Medicine and Pharmacy, Chengdu
   University of Traditional Chinese Medicine, for the assistance with
   molecular biology experiment.
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NR 63
TC 37
Z9 45
U1 9
U2 70
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JUN 15
PY 2022
VL 925
AR 175015
DI 10.1016/j.ejphar.2022.175015
EA MAY 2022
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1W6IP
UT WOS:000806876700002
PM 35561751
DA 2026-05-27
ER

PT J
AU Yu, G
   Feng, XL
AF Yu, Ge
   Feng, Xiaoling
TI Salidroside exerts anti-tumor effects in ovarian cancer by inhibiting
   STAT3/c-Myc pathway-mediated glycolysis
SO BIOMOLECULES AND BIOMEDICINE
LA English
DT Article
DE Ovarian cancer (OC); salidroside (SAL); signal transducer and activator
   of transcription 3 (STAT3)/c-Myc pathway; glycolysis
ID MESENCHYMAL TRANSITION
AB Salidroside (SAL) is a bioactive substance extracted from the traditional Chinese medicine Rhodiola rosea, which exhibits multiple pharmacological effects, such as anti-inflammatory, antioxidant, and anti-tumor properties. Currently, the effects of SAL on the malignant progression of ovarian cancer (OC) and its specific mechanism of action are not clear. Cell counting kit 8 (CCK-8), clone formation, Hoechst 33258 staining, flow cytometry, Transwell, western blotting, and immunofluorescence assays were performed to determine the impacts of SAL on the biological properties of OC cells (CAOV3 and SKOV3) and human normal ovarian epithelial cells (IOSE80). The binding activity of SAL and proteins was evaluated. Glucose consumption, lactate and ATP production, extracellular acidification rate (ECAR), and related proteins were measured to assess glycolysis. Animal models were established to evaluate the impact of SAL treatment in vivo and the expression levels of signal transducer and activator of transcription 3 (STAT3)/c-Myc pathway-related proteins were determined to explore the relationship between SAL and OC. The results showed that SAL reduced the viability, clone formation, migration, and invasion ability of CAOV3 and SKOV3 cells, and induced apoptosis. SAL inhibited epithelial-mesenchymal transition (EMT) and decreased glucose consumption, lactate and ATP production, and ECAR. SAL exhibited good binding activity with STAT3 and c-Myc and reduced the expression levels of STAT3/c-Myc pathway and glycolysis-related proteins in vitro and in vivo. In conclusion, SAL exerted anti-tumor effects by interfering with the malignant biological progression of OC cells by inhibiting STAT3/c-Myc pathway-mediated glycolysis.
C1 [Yu, Ge] Harbin Med Univ, Gynecol Dept, Canc Hosp, Harbin, Heilongjiang, Peoples R China.
   [Feng, Xiaoling] Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Gynecol Dept, Harbin, Heilongjiang, Peoples R China.
C3 Harbin Medical University; Heilongjiang University of Chinese Medicine
RP Feng, XL (corresponding author), Heilongjiang Univ Chinese Med, Affiliated Hosp 1, Gynecol Dept, Harbin, Heilongjiang, Peoples R China.
EM xiao1543902@163.com
FU BeiJing Heart To Heart Foundation [HXXT2022-ktyj002]
FX BeiJing Heart To Heart Foundation HXXT2022-ktyj002.
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NR 45
TC 9
Z9 12
U1 2
U2 12
PU ASSOC BASIC MEDICAL SCI FEDERATION BOSNIA & HERZEGOVINA SARAJEVO
PI CEKALUSA
PA UNIV SARAJEVO, MEDICAL FAC, CEKALUSA, SARAJEVO 90, BOSNIA & HERCEG
SN 2831-0896
EI 2831-090X
J9 BIOMOL BIOMED
JI Biomol. Biomed.
PY 2024
VL 25
IS 1
BP 82
EP 93
DI 10.17305/bb.2024.10867
EA AUG 2024
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA Q9U2V
UT WOS:001283720000001
PM 39097833
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Tang, YB
   Vater, C
   Jacobi, A
   Liebers, C
   Zou, XN
   Stiehler, M
AF Tang, Yubo
   Vater, Corina
   Jacobi, Angela
   Liebers, Cornelia
   Zou, Xuenong
   Stiehler, Maik
TI Salidroside exerts angiogenic and cytoprotective effects on human bone
   marrowderived endothelial progenitor cells via Akt/mTOR/p70S6K and MAPK
   signalling pathways
SO BRITISH JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE endothelial progenitor cell; salidroside; angiogenesis; reactive oxygen
   species; apoptosis; Akt; mTOR; p70S6K; MAPK
ID RHODIOLA-ROSEA; NITRIC-OXIDE; PROTEIN-KINASE; DOUBLE-BLIND; GROWTH;
   PROLIFERATION; EXPRESSION; EXTRACT; SHR-5; PERMEABILITY
AB Background and PurposeWith the increase of age, increased susceptibility to apoptosis and senescence may contribute to proliferative and functional impairment of endothelial progenitor cells (EPCs). The aim of this study was to investigate whether salidroside (SAL) can induce angiogenic differentiation and inhibit oxidative stress-induced apoptosis in bone marrow-derived EPCs (BM-EPCs), and if so, through what mechanism.
   Experimental ApproachBM-EPCs were isolated and treated with different concentrations of SAL for up to 4 days. Cell proliferation, migration and tube formation ability were detected by DNA content quantification, transwell assay and Matrigel-based angiogenesis assay. Gene and protein expression were assessed by qRT-PCR and Western blot respectively.
   Key ResultsTreatment with SAL promoted cellular proliferation and angiogenic differentiation of BM-EPCs, and increased VEGF and NO secretion, which in turn mediated the enhanced angiogenic differentiation of BM-EPCs. Furthermore, SAL significantly attenuated hydrogen peroxide (H2O2)-induced cell apoptosis, reduced the intracellular level of reactive oxygen species and restored the mitochondrial membrane potential of BM-EPCs. Moreover, SAL stimulated the phosphorylation of Akt, mammalian target of rapamycin and p70 S6 kinase, as well as ERK1/2, which is associated with cell migration and capillary tube formation. Additionally, SAL reversed the phosphorylation of JNK and p38 MAPK induced by H2O2 and suppressed the changes in the Bax/Bcl-xL ratio observed after stimulation with H2O2.
   Conclusions and ImplicationsThese findings identify novel mechanisms that regulate EPC function and suggest that SAL has therapeutic potential as a new agent to enhance vasculogenesis as well as protect against oxidative endothelial injury.
C1 [Tang, Yubo; Vater, Corina; Jacobi, Angela; Liebers, Cornelia; Stiehler, Maik] Tech Univ Dresden, Fac Med, Ctr Translat Bone Joint & Soft Tissue Res, D-01307 Dresden, Germany.
   [Tang, Yubo; Vater, Corina; Jacobi, Angela; Liebers, Cornelia; Stiehler, Maik] Tech Univ Dresden, Univ Hosp Carl Gustav Carus, Univ Ctr Orthopaed & Trauma Surg, D-01307 Dresden, Germany.
   [Tang, Yubo] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Pharm, Guangzhou 510275, Guangdong, Peoples R China.
   [Zou, Xuenong] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Spinal Surg, Guangzhou 510080, Guangdong, Peoples R China.
C3 Technische Universitat Dresden; Technische Universitat Dresden; Sun Yat
   Sen University; Sun Yat Sen University
RP Stiehler, M (corresponding author), Tech Univ Dresden, Fac Med, Ctr Translat Bone Joint & Soft Tissue Res, Fetscherstr 74, D-01307 Dresden, Germany.
EM zxnong@hotmail.com; Maik.stiehler@uniklinikum-dresden.de
FU German Academic Exchange Service; Federal Ministry of Education and
   Research [D/09/04774]; Chinese National Program on Key Basic Research
   (973 Program) [2012CB619100]
FX The authors wish to express their gratitude to Prof. Dr. Martin
   Bornhauser, Dr. Manja Wobus and Katrin Muller for providing bone marrow
   samples. This study was supported by the German Academic Exchange
   Service and Federal Ministry of Education and Research (D/09/04774), and
   Chinese National Program on Key Basic Research (973 Program, No.
   2012CB619100).
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U1 1
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PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0007-1188
EI 1476-5381
J9 BRIT J PHARMACOL
JI Br. J. Pharmacol.
PD MAY
PY 2014
VL 171
IS 9
BP 2440
EP 2456
DI 10.1111/bph.12611
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AE7DE
UT WOS:000334156100015
PM 24471788
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU Chen, XD
   Wei, JX
   Wang, HY
   Peng, YY
   Tang, C
   Ding, Y
   Li, S
   Long, ZY
   Lu, XM
   Wang, YT
AF Chen, Xing-Dong
   Wei, Jing-Xiang
   Wang, Hai-Yan
   Peng, Yu-Yuan
   Tang, Can
   Ding, Yang
   Li, Sen
   Long, Zai-Yun
   Lu, Xiu-Min
   Wang, Yong-Tang
TI Effects and mechanisms of salidroside on the behavior of SPS-induced
   PTSD rats
SO NEUROPHARMACOLOGY
LA English
DT Article
DE Salidroside; Post-traumatic stress disorder; Neuroinflammation; Single
   prolonged stress; Anxiety-like behavior; Learning and memory
ID NF-KAPPA-B; POSTTRAUMATIC-STRESS-DISORDER; REVERSES ANXIETY; MODEL;
   INFLAMMATION; DEFICITS; DISEASE
AB Post-traumatic stress disorder (PTSD) is a complex mental disorder, closely associated with stress and traumatic events. Salidroside (Sal) has been reported to possess neuroprotective effects. However, the behavioral effects and mechanisms of Sal on PTSD remain unknown. In this study, we utilized a rat model of PTSD induced by single prolonged stress (SPS) and administered Sal intraperitoneally (25, 50, 75 mg/kg/d) for 14 days. We then examined the behavioral effects and underlying mechanisms of Sal on SPS-induced PTSD rats. Our findings demonstrated that Sal alleviated anxiety-like behavior and spatial learning and memory impairment in SPSinduced PTSD rats. Furthermore, Sal treatment preserved the histomorphology of the hippocampal region. It was observed that Sal protected against hippocampal neuronal apoptosis in PTSD rats by reducing the number of TUNEL-positive cells and modulating apoptosis-related proteins (Bcl-2 and Bax). Additionally, Sal inhibited the activation of the NF-kappa B/iNOS/COX-2 signaling pathway in the hippocampus of PTSD rats, thereby suppressing the release of inflammatory factors (TNF-alpha and IL-1 beta) and the activation of microglia. Notably, Sal increased the expression of synapse-associated proteins PSD95 and Synapsin I in the hippocampus, while also enhancing dendritic density in the region. In conclusion, our results demonstrated that Sal could attenuate SPS-induced PTSD-like behaviors by inhibiting hippocampal neuronal apoptosis, enhancing hippocampal synaptic plasticity, and reducing neuroinflammatory responses. These findings may provide a foundation for the potential clinical application of Sal in the treatment of PTSD.
C1 [Chen, Xing-Dong; Wang, Hai-Yan; Li, Sen; Long, Zai-Yun; Wang, Yong-Tang] Army Med Univ, Daping Hosp, State Key Lab Trauma & Chem Poisoning, Chongqing 400042, Peoples R China.
   [Chen, Xing-Dong; Wei, Jing-Xiang; Peng, Yu-Yuan; Tang, Can; Ding, Yang; Lu, Xiu-Min] Chongqing Univ Technol, Coll Pharm & Bioengn, Chongqing 400054, Peoples R China.
C3 Army Medical University; Chongqing University of Technology
RP Wang, YT (corresponding author), Army Med Univ, Daping Hosp, State Key Lab Trauma & Chem Poisoning, Chongqing 400042, Peoples R China.; Lu, XM (corresponding author), Chongqing Univ Technol, Coll Pharm & Bioengn, Chongqing 400054, Peoples R China.
EM luxm@cqut.edu.cn; wangytlu@163.com
RI , haiyan/PNG-0073-2026
FU National Natural Science Founda-tion of China [82172194, 81971831];
   Personnel Innovation Ability Training Program of Army Medical Center of
   PLA [2019CXJSC007]; Scientific and Technological Research Pro-gram of
   Chongqing Municipal Education Commission [KJZD-K202001102]
FX This study was supported by the National Natural Science Founda-tion of
   China (82172194 and 81971831) , the Personnel Innovation Ability
   Training Program of Army Medical Center of PLA (2019CXJSC007) , and the
   Scientific and Technological Research Pro-gram of Chongqing Municipal
   Education Commission (KJZD-K202001102) .
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NR 65
TC 16
Z9 16
U1 0
U2 7
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0028-3908
EI 1873-7064
J9 NEUROPHARMACOLOGY
JI Neuropharmacology
PD DEC 1
PY 2023
VL 240
AR 109728
DI 10.1016/j.neuropharm.2023.109728
EA SEP 2023
PG 12
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA W0HJ0
UT WOS:001088523000001
PM 37742716
DA 2026-05-27
ER

PT J
AU Ye, RH
   Wang, Z
   Ren, Z
   Mao, YJ
   Xu, X
   Lv, X
AF Ye, Rui-Hai
   Wang, Zhen
   Ren, Zhe
   Mao, Ya-Jun
   Xu, Xue
   Lv, Xin
TI Integrative therapy for lower limb venous thrombosis in patients with
   COPD: a trial of Rhodiola rosea polyglucoside and pulmonary
   rehabilitation as a synergistic combination
SO RESPIRATORY MEDICINE
LA English
DT Article
DE Integrated Chinese and western medicine; treatment; COPD; Lower
   extremity venous thrombosis; Salidrosides; Pulmonary rehabilitation
   exercise
ID DISEASE; EXACERBATION; EMBOLISM; RISK
AB Background: This study aimed to evaluate the synergistic effect of salidroside and pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD) complicated by lower extremity deep vein thrombosis (LEDVT).<br /> Methods: Eighty-two patients with COPD and LEDVT were randomly assigned to a control group (n = 41; lowmolecular-weight heparin calcium plus pulmonary rehabilitation) or a combined group (n = 41; pulmonary rehabilitation plus salidroside). Clinical efficacy, hemorheological parameters, and serum hypoxia-inducible factor-1 alpha (HIF-1 alpha) and vascular endothelial growth factor (VEGF) levels were compared.<br /> Results: The total effective rate was higher in the combined group (95.12 %) than in the control group (75.61 %; P = 0.045), with no difference in adverse event incidence (17.07 % vs 9.76 %; P = 0.331). After 14 days, the combined group showed greater improvement in swelling, pain, skin temperature, and Homans's sign (all P < 0.05). Hemorheological parameters improved more significantly, including plasma viscosity (0.70 f 0.08 vs 1.25 f 0.30 mPa s), high-shear viscosity (4.10 f 0.22 vs 5.00 f 0.45 mPa s), and low-shear viscosity (7.84 f 0.20 vs 10.93 f 0.43 mPa s; all P < 0.001). HIF-1 alpha levels were lower and VEGF levels higher in the combined group (both P < 0.001).<br /> Conclusion: Salidroside combined with pulmonary rehabilitation significantly improved clinical outcomes, oxygenation, and endothelial repair in COPD with LEDVT, likely via modulation of the HIF-1 alpha/VEGF pathway, without increasing adverse effects.
C1 [Ye, Rui-Hai; Wang, Zhen; Lv, Xin] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, 54 Youdian Rd, Hangzhou, Peoples R China.
   [Ren, Zhe] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Thorac Surg Dept, Hangzhou, Peoples R China.
   [Mao, Ya-Jun; Xu, Xue] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Rehabil, Hangzhou, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical
   University; Zhejiang Chinese Medical University
RP Lv, X (corresponding author), Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Resp & Crit Care Med, 54 Youdian Rd, Hangzhou, Peoples R China.
EM XinLu652@yeah.net
FU Administration of Traditional Chinese Medicine of Zhejiang Province
   [2022ZB146]
FX This project was funded by Administration of Traditional Chinese
   Medicine of Zhejiang Province (2022ZB146) .
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NR 37
TC 0
Z9 0
U1 0
U2 0
PU W B SAUNDERS CO LTD
PI LONDON
PA 32 JAMESTOWN RD, LONDON NW1 7BY, ENGLAND
SN 0954-6111
EI 1532-3064
J9 RESP MED
JI Respir. Med.
PD NOV-DEC
PY 2025
VL 249
AR 108466
DI 10.1016/j.rmed.2025.108466
EA NOV 2025
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System
GA 9QU9D
UT WOS:001612829000001
PM 41167495
DA 2026-05-27
ER

PT J
AU Gao, H
   Peng, L
   Li, C
   Ji, QL
   Li, P
AF Gao, Hui
   Peng, Lu
   Li, Chao
   Ji, Qinlong
   Li, Ping
TI Salidroside Alleviates Cartilage Degeneration Through NF-κB Pathway in
   Osteoarthritis Rats
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Article
DE osteoarthritis; salidroside; cartilage degeneration; collagen fibrosis;
   inflammation; immune responses; NF-kappa B
ID CELLS; PROLIFERATION
AB Introduction: Osteoarthritis (OA) is the most common disease, which seriously affects the daily life of the elderly. Currently, no traditional or drug therapy has been shown to explicitly block the progression of OA. Salidroside (Sal) is a bioactive component of Rhodiola rosea, which has many beneficial effects on human health. However, the role and mechanism of Sal in OA have not been reported.
   Methods: We established an anterior cruciate ligament transection (ACLT)-induced OA Rat model. The rats were divided into five groups (n = 10): Control group; ACLT group; ACLT + Sal (12.5 mg/kg) group; ACLT + Sal (25 mg/kg) group; ACLT + Sal (50 mg/kg) group.
   Results: The study showed that Sal could significantly promote the proliferation of chondrocytes in OA rats induced by ACLT and restore the histological alteration of cartilage. Besides, Sal upregulated the levels of Collagen II and Aggrecan, and downregulated the level of MMP-13. Furthermore, Sal could reduce the number of CD4+IL-17(+) cells and decrease the levels of IL-17, IKB alpha and p65, while elevating the number of CD4+IL-10(+) cells and the level of IL-10. The decrease of IL-17 further inhibited the dissociation of IKB alpha to p65, thus reducing the release of TNF-alpha and VCAM-1. Taken together, Sal alleviates cartilage degeneration through promoting chondrocytes proliferation, inhibiting collagen fibrosis, and regulating inflammation and immune responses via NF-kappa B pathway in ACLT-induced OA Rats.
   Discussion: Collectively, our study investigates the role and mechanism of Sal in OA, which lays a foundation for the application of Sal in OA.
C1 [Gao, Hui; Li, Chao; Ji, Qinlong] Tinglin Hosp, Dept Orthopaed, Shanghai 201505, Peoples R China.
   [Peng, Lu] Hosp Tradit Chinese Med, Edong Healthcare Grp, Dept Orthopaed, Huangshi 435000, Hubei, Peoples R China.
   [Li, Ping] Hanchuan Peoples Hosp, Dept Rehabil, 1 Renmin Ave, Hanchuan 431600, Hubei, Peoples R China.
RP Li, P (corresponding author), Hanchuan Peoples Hosp, Dept Rehabil, 1 Renmin Ave, Hanchuan 431600, Hubei, Peoples R China.
EM kezzajps2jf@sina.com
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NR 44
TC 23
Z9 31
U1 3
U2 19
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2020
VL 14
BP 1445
EP 1454
DI 10.2147/DDDT.S242862
PG 10
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LC7KN
UT WOS:000525511600001
PM 32341638
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Ma, G
   Li, W
   Dou, DQ
   Chang, XL
   Bai, H
   Satou, T
   Li, J
   Sun, DJ
   Kang, TG
   Nikaido, T
   Koike, K
AF Ma, Guizhi
   Li, Wei
   Dou, Deqiang
   Chang, Xiaolong
   Bai, Hong
   Satou, Tadaaki
   Li, Jun
   Sun, Dianjia
   Kang, Tingguo
   Nikaido, Tamotsu
   Koike, Kazuo
TI Rhodiolosides A-E, monoterpene glycosides from Rhodiola rosea
SO CHEMICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE Rhodiola rosea; Crassulaceae; monoterpene; glycoside; rhodioloside
ID UNDERGROUND PART; INHIBITORS
AB Five new monoterpene glycosides, rhodiolosides A-E (1-5), were isolated from the roots of Rhodiola rosea (Crassulaceae). Their structures were elucidated as (2E,6E,4R)-4,8-dihydroxy-3,7-dimethyl-2,6-octadienyl beta-D-glueopyranoside (1), (2E,4R)-4-hydroxy-3,7-dimethyl-2,6-octadienyl beta-D-glueopyranosyl(1 -> 6)-beta-D-glucopyranoside (2), (2E,4R)-4-hydroxy-3,7-dimethyl-2,6-octadienyl beta-D-glueopyranosyl(1 -> 3)-beta-D-glucopyranoside (3), (2E,4R)-4,7-dihydroxy-3,7-dimethyl-2-octenyl beta-D-glucopyranoside (4), and (2E)-7-hydroxy-3,7-dimethyl-2-octenyl alpha-L-arabinopyranosyl(1 -> 6)-beta-D-glucopyranoside (5), on the basis of various spectroscopic analyses and chemical degradation.
C1 Toho Univ, Fac Pharmaceut Sci, Funabashi, Chiba 2748510, Japan.
   Xinjiang Med Univ, Coll Pharm, Urumki 830054, Peoples R China.
   Liaoning Univ Tradit Chinese Med, Coll Pharm, Shenyang 110032, Peoples R China.
C3 Toho University; Xinjiang Medical University; Liaoning University of
   Traditional Chinese Medicine
RP Koike, K (corresponding author), Toho Univ, Fac Pharmaceut Sci, 2-2-1 Miyama, Funabashi, Chiba 2748510, Japan.
EM koike@phar.toho-u.ac.jp
RI Dou, Deqiang/GLR-4592-2022; Li, Wei/Y-1312-2018
OI Satou, Tadaaki/0000-0002-0963-8487; Li, Wei/0000-0003-4143-8597
CR Akgul Y, 2004, FITOTERAPIA, V75, P612, DOI 10.1016/j.fitote.2004.06.002
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NR 16
TC 46
Z9 58
U1 1
U2 31
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0009-2363
J9 CHEM PHARM BULL
JI Chem. Pharm. Bull.
PD AUG
PY 2006
VL 54
IS 8
BP 1229
EP 1233
DI 10.1248/cpb.54.1229
PG 5
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA 077UM
UT WOS:000240056200035
PM 16880679
OA Bronze
DA 2026-05-27
ER

PT J
AU Xing, WM
   Gao, WY
   Su, HL
   Wang, SY
   Zhang, J
   Mao, GX
   Yan, J
AF Xing, Wenmin
   Gao, Wenyan
   Su, Huili
   Wang, Sanying
   Zhang, Jing
   Mao, Genxiang
   Yan, Jing
TI Salidroside influences the cellular cross-talk of human fetal lung
   diploid fibroblasts: A proteomic approach
SO ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
LA English
DT Article
DE Senescence; Salidroside; Human fetal lung diploid fibroblast cell;
   Proteomics
ID HUMAN DERMAL FIBROBLASTS; HEAT-SHOCK PROTEINS; SKIN IN-VIVO; OXIDATIVE
   STRESS; OVARIAN-CANCER; GROWTH-FACTOR; SENESCENCE; CELLS; EXPRESSION;
   IDENTIFICATION
AB Senescence is a complex multiple factor proces, which is still poorly understood. The purpose of this study was to find the proteome of cultured human fetal lung diploid fibroblasts (2BS) of different population doubling (PD), as well as the altered proteome induced by salidroside (SAL) in 2BS cells. Proteins were identified by two-dimensional electrophoresis (2-DE) combining matrix-assisted laser desorption/ionization-time and flight mass spectrometry (MAL DI-TOF/MS). As a result, we found 16 proteins with two-fold variations in senescent cells or after SAL treatment, some being reduced such as reticulocalbin-1, heat shock protein beta-6, elongation factor 1 delta, F-actin-capping protein subunit alpha-1, and chloride intracellular channel 1. In contrast, 40S ribosomal protein SA, proteasome subunit alpha type-5, and zinc finger BED domain-containing protein 5 increased with cell age. Furthermore, heat shock protein beta-6, Zinc finger BED domain-containing protein 5 was increased in PD30 cells after 10 mu M SAL treatment, whereas, elongation factor 1-delta, 6-phosphogluconolactonase, Nucleoside diphosphate kinase A, F-actin-capping protein subunit alpha-1, Probable ATP-dependent RNA helicase DDX41, Chloride intracellular channel 1, and Peroxiredoxin-6 were increased in PD50 cells after 10 mu M SAL treatment. Some of these proteins were involved in the protein synthetic and degradative pathways, which emphasizes the metabolic disorder or functional impairment of cell senescence. Moreover, these proteins could be candidate biomarkers for evaluating the SAL anti-senescence effect.
C1 [Xing, Wenmin; Su, Huili; Wang, Sanying; Zhang, Jing; Mao, Genxiang; Yan, Jing] Zhejiang Hosp, Dept Geriatr, Zhejiang Prov Key Lab Geriatr, Hangzhou 310013, Zhejiang, Peoples R China.
   [Gao, Wenyan] Zhejiang Acad Med Sci, Inst Mat Med, Hangzhou 310013, Zhejiang, Peoples R China.
C3 Zhejiang Academy of Medical Sciences
RP Mao, GX; Yan, J (corresponding author), Zhejiang Hosp, Dept Geriatr, Zhejiang Prov Key Lab Geriatr, Hangzhou 310013, Zhejiang, Peoples R China.
EM maogenxiang@163.com; zjicu@vip.163.com
RI wang, sanying/HIZ-7552-2022
OI wang, sanying/0000-0002-8172-876X
FU National Natural Science Foundation of China [81771520, 31201040]; funds
   from the Science Technology Department of Zhejiang Province
   [2016C34002]; Health Bureau of Zhejiang Province [2017KY189, 2015DTA001,
   2013KY A003]; Chinese traditional medicine science and technology
   projects of Zhejiang Province [2017 ZB002]; Ministry of Health of China
   [WKJ2011-2-014]
FX This study was supported by the National Natural Science Foundation of
   China (81771520 &31201040), and funds from the Science Technology
   Department of Zhejiang Province (2016C34002), the Health Bureau of
   Zhejiang Province (2017KY189, 2015DTA001& 2013KY A003), Chinese
   traditional medicine science and technology projects of Zhejiang
   Province (2017 ZB002), and Ministry of Health of China (WKJ2011-2-014).
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NR 63
TC 3
Z9 3
U1 0
U2 16
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1382-6689
EI 1872-7077
J9 ENVIRON TOXICOL PHAR
JI Environ. Toxicol. Pharmacol.
PD MAR
PY 2018
VL 58
BP 114
EP 121
DI 10.1016/j.etap.2018.01.001
PG 8
WC Environmental Sciences; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Pharmacology & Pharmacy; Toxicology
GA FZ1KC
UT WOS:000427334500014
PM 29329019
DA 2026-05-27
ER

PT J
AU Xing, S
   Xu, SY
   Wang, LJ
   Guo, LY
   Zhou, X
   Wu, HX
   Wang, W
   Liu, LY
AF Xing, Shan
   Xu, Shuyi
   Wang, Linjiao
   Guo, Liyuan
   Zhou, Xin
   Wu, Haoxin
   Wang, Wei
   Liu, Lanying
TI Salidroside exerts antidepressant-like action by promoting adult
   hippocampal neurogenesis through SIRT1/PGC-1α signalling
SO ACTA NEUROPSYCHIATRICA
LA English
DT Article
DE Salidroside; depression; hippocampal; Sirtuin1; neurogenesis
ID DEPRESSION; STRESS; ACTIVATION; SIRT1
AB Depression is one of the major mental disorders, which seriously endangers human health, brings a serious burden to patients' families. In this study, we intended to further explore the antidepressant-like effect and possible molecular mechanisms of Salidroside (SAL). We built corticosterone (CORT)-induced depressive mice model and used behavioural tests to evaluate depression behaviour. To explore the molecular mechanisms of SAL, we employed a variety of methods such as immunofluorescence, western blot, pharmacological interference, etc. The results demonstrated that SAL both at 25 mg/kg and 50 mg/kg can reduce immobility time in the tail suspension test (TST). At the same time, SAL treatment could restore the reduced sugar water intake preference in the sucrose preference test (SPT) in CORT-induced depressive mice and reduce the immobility time in TST and forced swimming experiments (FST). In addition, SAL treatment reversed the reduction in the number of Ki-67, BrdU, and NeuN in the hippocampus due to CORT treatment. SAL treatment also restored the expression of SIRT1, PGC-1 alpha, brain-derived neurotrophic factor (BDNF) and other proteins in the hippocampus. In addition, after blocking SIRT1 signalling with EX527, we found that the treatment with SAL failed to reduce the immobility time in TST and FST, the level of SIRT1 and PGC-1 alpha activity were correspondingly downregulated, and the expression of DCX and Ki-67 in the hippocampus failed to be activated. These findings suggested that SAL exerts antidepressant-like effects by promoting hippocampal neurogenesis through the SIRT1/PGC-1 alpha signalling pathway.
C1 [Xing, Shan; Xu, Shuyi; Wang, Linjiao; Zhou, Xin; Wu, Haoxin] Nanjing Univ Chinese Med, Sch Chinese Med, Nanjing, Peoples R China.
   [Guo, Liyuan] Zhejiang Chinese Med Univ, Hangzhou, Peoples R China.
   [Wang, Wei] Nanjing Univ Chinese Med, Sch Med, Nanjing, Peoples R China.
   [Liu, Lanying] Shanghai Mental Hlth Ctr, Dept Psychiat, Shanghai, Peoples R China.
   [Liu, Lanying] Shanghai Jiao Tong Univ, Dept Psychiat, Sch Med, Shanghai, Peoples R China.
   [Liu, Lanying] Shanghai Inst Mental Dis Tradit Chinese Med, Shanghai, Peoples R China.
C3 Nanjing University of Chinese Medicine; Zhejiang Chinese Medical
   University; Nanjing University of Chinese Medicine; Shanghai Jiao Tong
   University; Shanghai Jiao Tong University
RP Wu, HX (corresponding author), Nanjing Univ Chinese Med, Sch Chinese Med, Nanjing, Peoples R China.; Wang, W (corresponding author), Nanjing Univ Chinese Med, Sch Med, Nanjing, Peoples R China.; Liu, LY (corresponding author), Shanghai Mental Hlth Ctr, Dept Psychiat, Shanghai, Peoples R China.; Liu, LY (corresponding author), Shanghai Jiao Tong Univ, Dept Psychiat, Sch Med, Shanghai, Peoples R China.; Liu, LY (corresponding author), Shanghai Inst Mental Dis Tradit Chinese Med, Shanghai, Peoples R China.
EM balindaliu@163.com; wangw@njucm.edu.cn; wuhaoxin@sohu.com
RI Guo, Liyuan/OUJ-2425-2025; liu, lanying/ODL-0836-2025; Xu,
   Shuyi/PWG-1377-2026
FU Shanghai Traditional Chinese Medicine Science and Technology Plan
   [2022CX004]; Shanghai Technical Standardization Management and Promotion
   Project [SHDC22023212]; National Natural Science Foundation of China
   [81803748]; Traditional Chinese Medicine Science and Technology
   Development Plan Project of Jiangsu Province [YB2020002]
FX The study was supported by Shanghai Traditional Chinese Medicine Science
   and Technology Plan (Grant No. 2022CX004), Shanghai Technical
   Standardization Management and Promotion Project (Project Number:
   SHDC22023212), the National Natural Science Foundation of China (grant
   numbers 81803748) and it was also supported by the Traditional Chinese
   Medicine Science and Technology Development Plan Project of Jiangsu
   Province (No. YB2020002).
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NR 55
TC 10
Z9 11
U1 2
U2 11
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0924-2708
EI 1601-5215
J9 ACTA NEUROPSYCHIATR
JI Acta Neuropsychiatr.
PD DEC
PY 2024
VL 36
IS 6
BP 446
EP 456
DI 10.1017/neu.2024.28
EA SEP 2024
PG 11
WC Neurosciences; Psychiatry
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Psychiatry
GA Q3F3X
UT WOS:001324095600001
PM 39344773
DA 2026-05-27
ER

PT J
AU Teng, L
   Gao, JF
   Zhou, L
   Xian, QY
   Li, JK
   Yang, SJ
AF Teng, L.
   Gao, J. F.
   Zhou, L.
   Xian, Q. Y.
   Li, J. K.
   Yang, S. J.
TI Influence of Salidroside on Expression Level of Endothelin-1 and Its
   Receptors under Hypoxic Conditions in Chicken Embryonic Pulmonary Artery
   Smooth Muscle Cells
SO PAKISTAN VETERINARY JOURNAL
LA English
DT Article
DE Broiler chicken; Endothelin-1; Hypoxia; Pulmonary artery smooth muscle
   cells; Salidroside
ID HYPERTENSION; APOPTOSIS; LUNGS; MODEL
AB Salidroside (SDS), a traditional Chinese medicine, possesses many important functional activities such as anti-hypoxia, anti-fatigue, enhancing work performance, and is especially famous in the treatment of mountain mal-hypoxia in Tibet. Here we designed the study to evaluate the pharmacological effect of SDS on expression of ET-1 and its receptors in hypoxia-treated pulmonary artery smooth muscle cells (PASMCs). Chicken embryonic PASMCs incubated with or without SDS for lh were then subjected to the hypoxic exposure for 24h. We evaluated the expression levels of ET-1 and its receptors mRNA in treated PASMCs. Compared with the hypoxia-treated group, the levels of ET-1 gene expression were notably decreased in both the moderate dose group (80 mu g/ml) and the high dose group (120 mu g/ml) (P<0.01, P<0.05) respectively, but no obvious decrease was found in the low dose group (40ng/m1). Meanwhile, pretreatment with SDS (40, 80, 120 mu g/ml) was found to be effective in reducing (P<0.01, P<0.01, P<0.05) the expression levels of ETA in avian PASMCs exposed to hypoxic conditions in vitro. Moreover, pretreatment with SDS markedly attenuated (P<0.01) ETB mRNA expression levels in the low-dose group (40ng/m1) and the moderate-dose group (80ng/m1), while in high dose group (120ng/m1), there was no obvious decrease. Collectively, our findings showed that SDS has a significant influence on the expression of ET-1 and its receptors in hypoxia-treated avian PASMCs. (C) 2016 PVJ. All rights reserved
C1 [Teng, L.; Gao, J. F.; Zhou, L.; Xian, Q. Y.; Yang, S. J.] Wuhan Univ, Ctr Expt Anim, Wuhan 430071, Peoples R China.
   [Gao, J. F.; Li, J. K.] Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Peoples R China.
   [Teng, L.] Wuhan Med Care Ctr Women & Children, Dept Pathol, Wuhan 430016, Peoples R China.
C3 Wuhan University; Huazhong Agricultural University
RP Yang, SJ (corresponding author), Wuhan Univ, Ctr Expt Anim, Wuhan 430071, Peoples R China.; Li, JK (corresponding author), Huazhong Agr Univ, Coll Vet Med, Wuhan 430070, Peoples R China.
EM lijk210@sina.com; 00030941@whu.edu.cn
RI Li, Jiakui/HDN-1674-2022
OI Li, Jiakui/0000-0002-6065-6648
FU Natural Science Foundation of Hubei Province [2015CFB164, 2015CFA075];
   China Postdoctoral Science Foundation [2015M572199, 2013M531745];
   National Natural Science Foundation of China [30972222, 81301428];
   Fundamental Research Funds for the Central Universities [2042015kf0017,
   2042015kf0188]
FX The research presented in this paper was supported by the Natural
   Science Foundation of Hubei Province (No: 2015CFB164, 2015CFA075), the
   China Postdoctoral Science Foundation (No: 2015M572199, 2013M531745),
   the National Natural Science Foundation of China (No. 30972222,
   81301428) and the Fundamental Research Funds for the Central
   Universities (2042015kf0017, 2042015kf0188).
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NR 29
TC 5
Z9 5
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PU UNIV AGRICULTURE, FAC VETERINARY SCIENCE
PI FAISALABAD
PA UNIV AGRICULTURE, FAC VETERINARY SCIENCE, FAISALABAD, 00000, PAKISTAN
SN 0253-8318
EI 2074-7764
J9 PAK VET J
JI Pak. Vet. J.
PY 2016
VL 36
IS 2
BP 214
EP 218
PG 5
WC Veterinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Veterinary Sciences
GA DK2MR
UT WOS:000374749300018
DA 2026-05-27
ER

PT J
AU Huang, YX
   He, YJ
   Zhao, XL
   Zou, YJ
   Ding, WJ
   Wei, LJ
AF Huang, Yuxing
   He, Yijia
   Zhao, Xiaolong
   Zou, Yongjie
   Ding, Weijun
   Wei, Linjie
TI Salidroside Exerts Neuroprotective Effects via Inhibiting Ferroptosis in
   Mice with Traumatic Brain Injury
SO NEUROCHEMICAL RESEARCH
LA English
DT Article
DE Salidroside; Traumatic brain injury; Lipid peroxidation; Ferroptosis;
   Neuroprotection
ID NEUROINFLAMMATION
AB Traumatic brain injury (TBI) carries a high incidence of morbidity and mortality worldwide. We aim to explore the neuroprotective effects of Salidroside (Sal) on TBI and the specific mechanisms involved. The controlled cortical impact (CCI) was adopted to induce TBI in mice. Mice were randomly divided into the following groups: Sham group, TBI group, low-dose Sal (Sal-L) group, High-dose Sal (Sal-H) group and the Ferrostatin-1 (Fer) group. Neurological function of mice was assessed by Neurological Severity Score and behavioral tests, with Hematoxylin-eosin and Nissl staining for histological analysis. Terminal deoxynucleotidyl transferase mediated dUTP nick end labeling assay was employed to detect neuronal apoptosis. Evans blue extravasation was observed to assess blood-brain barrier (BBB) permeability. Immunohistochemistry detected the astrocyte and microglial markers. Remyelination was evaluated by immunofluorescent labeling of myelin basic protein and Luxol Fast Blue staining. Reactive oxygen species (ROS), malondialdehyde, and glutathione levels were detected to assess lipid peroxidation. Ferroptosis was accessed by Prussian blue staining and western blot. Sal improved neurological deficits, reduced histopathological damage, inhibited neuronal apoptosis, and maintained neuronal structural stability in TBI mice. Sal downregulated the expression of Glial Fibrillary Acidic Protein (GFAP) and Iba1, indicating the suppression of astrocyte and microglia activation. Additionally, Sal alleviated BBB damage and promoted myelin regeneration. Sal treatment caused a decrease in ROS and malondialdehyde (MDA), while an increase in glutathione. Notably, Sal exhibited inhibitory effects on ferroptosis, as evidenced by reduced iron deposits, decreased iron ion levels, and modulated expression of key proteins involved in the ferroptosis, including upregulation of ferroptosis-inhibitory proteins and downregulation of ferroptosis-promoting proteins. Sal inhibits lipid peroxidation to suppress ferroptosis, thus exerting a neuroprotective effect on TBI mice.
C1 [He, Yijia; Ding, Weijun] Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China.
   [Huang, Yuxing] Hosp Chengdu Univ Tradit Chinese Med, Dept Neurosurg, Chengdu, Peoples R China.
   [Zhao, Xiaolong; Wei, Linjie] PLA 956 Hosp, Army Clin Key Cultivat Specialty, Dept Neurosurg, 6 Shuangyong West Rd,Bayi Town, Linzhi 860000, Xizang, Peoples R China.
   [Zou, Yongjie] 908th Hosp Joint Logist Support Forces Chinese PLA, Dept Orthoped, Nanchang 330002, Jiangxi, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Ding, WJ (corresponding author), Chengdu Univ Tradit Chinese Med, Chengdu, Peoples R China.; Wei, LJ (corresponding author), PLA 956 Hosp, Army Clin Key Cultivat Specialty, Dept Neurosurg, 6 Shuangyong West Rd,Bayi Town, Linzhi 860000, Xizang, Peoples R China.
EM dingweijun@cdutcm.edu.cn; weilinjie8888@163.com
FU Xizang Autonomous Region Science and Technology Program [XZ202201YD0028
   C]
FX This work was supported by Grant No. XZ202201YD0028 C (Linjie Wei) from
   Xizang Autonomous Region Science and Technology Program (Central
   government funds for guiding local scientific and technological
   development).
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NR 41
TC 0
Z9 0
U1 6
U2 14
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD JUN 21
PY 2025
VL 50
IS 4
AR 204
DI 10.1007/s11064-025-04430-x
PG 16
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 3ZB8R
UT WOS:001512430800001
PM 40542883
DA 2026-05-27
ER

PT J
AU Shi, XL
   Dong, N
   Qiu, Q
   Li, SH
   Zhang, JX
AF Shi, Xiaoling
   Dong, Nuo
   Qiu, Qi
   Li, Shanhua
   Zhang, Jiaxing
TI Salidroside Prevents Hypoxia-Induced Human Retinal Microvascular
   Endothelial Cell Damage Via miR-138/ROBO4 Axis
SO INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
LA English
DT Article
DE retinal microvascular endothelial cell; salidroside; hypoxia; miR-138;
   ROBO4
ID UP-REGULATION; EXPRESSION; PROTECTS; APOPTOSIS; STRESS; INJURY
AB PURPOSE. Retinopathies are associated with the injury of retinal microvascular endothelial cells. Salidroside (SAL) is a medicinal supplement that has antioxidative and cytoprotective properties. We hypothesized that SAL might have a protective function in retinopathies. This research aims to explore the function and mechanism of SAL in hypoxia-induced retinal microvascular endothelial cell injury.
   METHODS. Human retinal microvascular endothelial cells (HRMECs) injury was induced by culturing under hypoxic condition. The function of SAL on HRMECs injury was investigated using cell counting kit-8, 5-ethynyl-2'-deoxyuridine (EdU) staining, flow cytometry, Western blotting, and enzyme linked immunosorbent assay. MicroRNA (miR)-138, roundabout 4 (ROBO4), and proteins in the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways were examined using quantitative reverse transcription polymerase chain reaction or Western blotting. The target correlation was determined by dual-luciferase reporter analysis and RNA immunoprecipitation.
   RESULTS. Hypoxia resulted in proliferation inhibition, cycle arrest, apoptosis, inflammatory reaction, and oxidative stress in HRMECs. SAL attenuated hypoxia-induced HRMECs injury via increasing cell proliferation, and mitigating cycle arrest, apoptosis, inflammatory reaction, and oxidative stress. MiR-138 expression was enhanced by hypoxia, and decreased via SAL stimulation. MiR-138 upregulation reversed the influence of SAL on hypoxia-induced HRMECs injury. ROBO4 was targeted via miR-138. ROBO4 overexpression weakened the role of miR-138 in HRMECs injury. The PI3K/AKT/mTOR pathway was inactivated under hypoxic condition, and SAL increased the activation of PI3K/AKT/mTOR pathways by decreasing miR-138.
   CONCLUSIONS. SAL protected against hypoxia-induced HRMECs injury through regulating miR-138/ROBO4 axis, indicating the protective potential of SAL in retinopathies.
C1 [Shi, Xiaoling; Qiu, Qi; Li, Shanhua; Zhang, Jiaxing] Xiamen Univ, Med Coll, Inst Brain Dis & Cognit, Xiangan Nan Rd, Xiamen 361102, Fujian, Peoples R China.
   [Shi, Xiaoling; Dong, Nuo] Xiamen Univ, Med Coll, Affiliated Xiamen Eye Ctr, Xiamen, Fujian, Peoples R China.
C3 Xiamen University; Xiamen University
RP Zhang, JX (corresponding author), Xiamen Univ, Med Coll, Inst Brain Dis & Cognit, Xiangan Nan Rd, Xiamen 361102, Fujian, Peoples R China.; Dong, N (corresponding author), Xiamen Univ, Med Coll, Affiliated Xiamen Eye Ctr, Xiamen, Fujian, Peoples R China.
EM profeye@163.com; zhangjiaxing@xmu.edu.cn
FU National Natural Science Foundation of China (NSFC) [81970771,
   81871519]; Natural Science Foundation of Fujian [2020D027]; Xiamen Key
   Medical and Health Project [3502Z20191101]
FX Supported by grants from the National Natural Science Foundation of
   China (NSFC no. 81970771, 81871519), Natural Science Foundation of
   Fujian (2020D027), Xiamen Key Medical and Health Project (no.
   3502Z20191101).
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PU ASSOC RESEARCH VISION OPHTHALMOLOGY INC
PI ROCKVILLE
PA 12300 TWINBROOK PARKWAY, ROCKVILLE, MD 20852-1606 USA
SN 0146-0404
EI 1552-5783
J9 INVEST OPHTH VIS SCI
JI Invest. Ophthalmol. Vis. Sci.
PD JUL
PY 2021
VL 62
IS 9
AR 25
DI 10.1167/iovs.62.9.25
PG 10
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA UA5JS
UT WOS:000685198300018
PM 34269814
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, CG
   Wang, QQ
   Lou, YT
   Xu, JX
   Feng, ZH
   Chen, Y
   Tang, Q
   Zheng, G
   Zhang, ZJ
   Wu, YS
   Tian, NF
   Zhou, YF
   Xu, HZ
   Zhang, XL
AF Wang, Chenggui
   Wang, Qingqing
   Lou, Yiting
   Xu, Jianxiang
   Feng, Zhenhua
   Chen, Yu
   Tang, Qian
   Zheng, Gang
   Zhang, Zengjie
   Wu, Yaosen
   Tian, Naifeng
   Zhou, Yifei
   Xu, Huazi
   Zhang, Xiaolei
TI Salidroside attenuates neuroinflammation and improves functional
   recovery after spinal cord injury through microglia polarization
   regulation
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE salidroside; spinal cord injury; microglia; M1 polarization; M2
   polarization; autophagic flux; AMPK
ID PROMOTES LOCOMOTOR RECOVERY; OXIDATIVE STRESS; MACROPHAGE POLARIZATION;
   MEDIATED NEUROTOXICITY; INDUCED AUTOPHAGY; ADOPTIVE TRANSFER; M2
   MACROPHAGES; APOPTOSIS; ACTIVATION; RESPONSES
AB Spinal cord injury (SCI) is a severe neurological disease; however, few drugs have been proved to treat SCI effectively. Neuroinflammation is the major pathogenesis of SCI secondary injury and considered to be the therapeutic target of SCI. Salidroside (Sal) has been reported to exert anti-inflammatory effects in airway, adipose and myocardial tissue; however, the role of Sal in SCI therapeutics has not been clarified. In this study, we showed that Sal could improve the functional recovery of spinal cord in rats as revealed by increased BBB locomotor rating scale, angle of incline, and decreased cavity of spinal cord injury and apoptosis of neurons invivo. Immunofluorescence double staining of microglia marker and M1/M2 marker demonstrated that Sal could suppress M1 microglia polarization and activate M2 microglia polarization invivo. To verify how Sal exerts its effects on microglia polarization and neuron protection, we performed the mechanism study invitro in microglia cell line BV-2 and neuron cell line PC12. The results showed that Sal prevents apoptosis of PC12 cells in coculture with LPS-induced M1 BV-2 microglia, also the inflammatory secretion phenotype of M1 BV-2 microglia was suppressed by Sal, and further studies demonstrated that autophagic flux regulation through AMPK/mTOR pathway was involved in Sal regulated microglia polarization after SCI. Overall, our study illustrated that Sal could promote spinal cord injury functional recovery in rats, and the mechanism may relate to its microglia polarization modulation through AMPK-/mTOR-mediated autophagic flux stimulation.
C1 [Wang, Chenggui; Wang, Qingqing; Lou, Yiting; Xu, Jianxiang; Feng, Zhenhua; Chen, Yu; Tang, Qian; Zheng, Gang; Zhang, Zengjie; Wu, Yaosen; Tian, Naifeng; Zhou, Yifei; Xu, Huazi; Zhang, Xiaolei] Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed, Wenzhou, Zhejiang, Peoples R China.
   [Wang, Chenggui; Wang, Qingqing; Lou, Yiting; Xu, Jianxiang; Feng, Zhenhua; Chen, Yu; Tang, Qian; Zheng, Gang; Zhang, Zengjie; Wu, Yaosen; Tian, Naifeng; Zhou, Yifei; Xu, Huazi; Zhang, Xiaolei] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China.
   [Wang, Chenggui; Wang, Qingqing; Lou, Yiting; Xu, Jianxiang; Feng, Zhenhua; Chen, Yu; Tang, Qian; Zheng, Gang; Zhang, Zengjie; Wu, Yaosen; Tian, Naifeng; Zhou, Yifei; Xu, Huazi; Zhang, Xiaolei] Key Lab Orthopaed Zhejiang Prov, Wenzhou, Peoples R China.
   [Zhang, Xiaolei] Chinese Orthopaed Regenerat Med Soc, Hangzhou, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University
RP Xu, HZ; Zhang, XL (corresponding author), Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed, Wenzhou, Zhejiang, Peoples R China.; Xu, HZ; Zhang, XL (corresponding author), Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Zhejiang, Peoples R China.; Xu, HZ; Zhang, XL (corresponding author), Key Lab Orthopaed Zhejiang Prov, Wenzhou, Peoples R China.; Zhang, XL (corresponding author), Chinese Orthopaed Regenerat Med Soc, Hangzhou, Zhejiang, Peoples R China.
EM spinexu@163.com; zhangxiaolei@wmu.edu.cn
RI ; Wang, Chenggui/PMR-3500-2026; zheng, gang/KMX-5568-2024; XU,
   JIANXIANG/HCH-2510-2022; Zhang, Xiaolei/AFS-0882-2022
OI zhang, zengjie/0000-0002-1760-8827; Wang, Chenggui/0000-0002-0512-784X;
   Zhang, Xiaolei/0000-0003-0117-7599
FU National Natural Science Foundation of China [81401871, 81401162,
   81572227]; Zhejiang Provincial Natural Science Foundation of China
   [LY17H060010, LY14H170002]
FX This study was supported by National Natural Science Foundation of China
   (81401871, 81401162 and 81572227), Zhejiang Provincial Natural Science
   Foundation of China (LY17H060010 and LY14H170002).
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NR 80
TC 169
Z9 187
U1 0
U2 52
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD FEB
PY 2018
VL 22
IS 2
BP 1148
EP 1166
DI 10.1111/jcmm.13368
PG 19
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA FT7VO
UT WOS:000423361500041
PM 29148269
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Fan, FF
   Xu, N
   Sun, YC
   Li, XH
   Gao, XC
   Yi, XZ
   Zhang, Y
   Meng, XL
   Lin, JM
AF Fan, Fangfang
   Xu, Ning
   Sun, Yucheng
   Li, Xuanhao
   Gao, Xinchang
   Yi, Xizhen
   Zhang, Yi
   Meng, Xianli
   Lin, Jin-Ming
TI Uncovering the Metabolic Mechanism of Salidroside AlleviatingMicroglial
   Hypoxia Inflammation Based on Microfluidic Chip-MassSpectrometry
SO JOURNAL OF PROTEOME RESEARCH
LA English
DT Article
DE salidroside; metabolic mechanism; microglia; hypoxia inflammation;
   microfluidic chip-mass spectrometry
ID ANGELICA-SINENSIS; INDUCIBLE FACTOR; ALTITUDE; MITOCHONDRIA; SUCCINATE;
   IMMUNITY; NEURONS; INJURY; CELLS
AB Microglia are the main immune cells in the brain playing a critical rolein neuroinflammation, and numerous pieces of evidence have proved that energymetabolism is closely associated with inflammation in activated microglia. Salidroside(Sal) isolated from Tibetan medicineRhodiola crenulatecan inhibit microglialhypoxia inflammation (HI). However, whether the inhibition is due to theintervening energy metabolic process in microglia is not clear. In this work, thehypoxic microenvironment of BV2 microglial cells was simulated using deferoxamine(DFO)in vitroand the change of cell metabolites (lactate, succinate, malate, andfumarate) was real-time online investigated based on a cell microfluidic chip-massspectrometry (CM-MS) system. Meanwhile, for confirming the metabolic mechanismof BV2 cells under hypoxia, the level of HI-related factors (LDH, ROS, HIF-1 alpha, NF-Kappa B p65, TNF-alpha, IL-1 beta, and IL-6) was detected by molecular biotechnology.Integration of the detected results revealed that DFO-induced BV2 cell HI wasassociated with the process of energy metabolism, in which cell energy metabolismchanged from oxidative phosphorylation to glycolysis. Furthermore, administration of Sal treatment could effectively invert thischange, and two metabolites of Sal were identified: tyrosol and 4-hydroxyphenylacetic acid. In general, we illustrated a newmechanism of Sal for reducing BV2 cell HI injury and presented a novel analysis strategy that opened a way for real-time onlinemonitoring of the energy metabolic mechanism of the effect of drugs on cells and further provided a superior strategy to screennatural drug candidates for HI-related brain disease treatment.
C1 [Fan, Fangfang; Li, Xuanhao; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.
   [Fan, Fangfang; Zhang, Yi; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu 611137, Peoples R China.
   [Fan, Fangfang; Xu, Ning; Sun, Yucheng; Gao, Xinchang; Yi, Xizhen; Lin, Jin-Ming] Tsinghua Univ, Dept Chem, Beijing Key Lab Microanalyt Methods & Instrumenta, MOE Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China.
   [Xu, Ning] Chinese Acad Agr Sci, Inst Qual Stand & Testing Technol Agroprod, Beijing 100081, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Tsinghua University; Chinese Academy of
   Agricultural Sciences; Institute of Quality Standards & Testing
   Technology for Agro-Products, CAAS
RP Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu 611137, Peoples R China.; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu 611137, Peoples R China.; Lin, JM (corresponding author), Tsinghua Univ, Dept Chem, Beijing Key Lab Microanalyt Methods & Instrumenta, MOE Key Lab Bioorgan Phosphorus Chem & Chem Biol, Beijing 100084, Peoples R China.
EM xlm999@cdutcm.edu.cn; jmlin@mail.tsinghua.edu.cn
OI Lin, Jin-Ming/0000-0001-8891-0655; Xu, Ning/0009-0006-3543-736X
FU National Natural Science Foundation of China [81973569, 21727814,
   21621003]; National Key R&D Program of China [2017YFC1703904]; State
   Administration of Traditional Chinese Medicine of the People's Republic
   of China [201507002]; Major Science and Technology Project of Sichuan
   Science and Technology Department [2019YFSY0046]
FX This study was supported by the National Natural Science Foundation of
   China (81973569, 21727814, and 21621003), t h e Na t i o n a l Ke y R&D
   Pr o g r a m o f C h i n a (2017YFC1703904), State Administration of
   Traditional Chinese Medicine of the People's Republic of China
   (201507002), and the Major Science and Technology Project of Sichuan
   Science and Technology Department (2019YFSY0046).
NR 0
TC 30
Z9 34
U1 3
U2 44
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1535-3893
EI 1535-3907
J9 J PROTEOME RES
JI J. Proteome Res.
PD APR 1
PY 2022
VL 21
IS 4
BP 921
EP 929
DI 10.1021/acs.jproteome.1c00647
PG 9
WC Biochemical Research Methods
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 0P4MB
UT WOS:000784194300007
PM 34851127
DA 2026-05-27
ER

PT J
AU Qian, EW
   Ge, DT
   Kong, SK
AF Qian, Erin Wei
   Ge, Daniel Tianfang
   Kong, Siu-Kai
TI Salidroside promotes erythropoiesis and protects erythroblasts against
   oxidative stress by up-regulating glutathione peroxidase and thioredoxin
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Salidroside; Erythropoiesis; Reactive oxygen species; Oxidative stress;
   Thioredoxin; Glutathione peroxidase
ID RHODIOLA-ROSEA; ERYTHROID-DIFFERENTIATION; DOUBLE-BLIND; TF-1 CELLS;
   EXTRACT; GROWTH; SHR-5; INVOLVEMENT; APOPTOSIS; FATIGUE
AB Ethnopharmacological relevance: Rhodiola rosea is commonly used in China and Tibet folk medicine for the treatment of high altitude sickness, anoxia and mountain malhypoxia.
   Aim of study: Salidroside (SDS) is an active ingredient of Rhodiola rosea. This study attempted to examine the potential erythropoiesis-stimulating and anti-oxidative effect of SDS in TF-1 erythroblasts.
   Materials and methods: The erythropoiesis-promoting effect was determined by treating human TF-1 cells, one of the popular in vitro models for studying erythropoiesis, with SDS in the presence and absence of erythropoietin (EPO) through the measurement of the expression of a series of erythroid markers such as glycophorin A (GPA), transferrin receptor (CD71) and hemoglobin (Hb). The potential protective effect of SDS against H2O2-induced apoptosis and its underlying mechanism in TF-1 erythroblasts were examined by flow cytometry and Western blot analysis.
   Results: SDS promotes erythropoiesis in the EPO-treated cells and it also reduces the number of apoptotic cells in TF-1 erythroblasts after H2O2 treatment probably through the up-regulation of protective proteins thioredoxin-1 (Trx1) and glutathione peroxidase-1 (GPx1).
   Conclusion: Our study provides evidence to explain the ethnopharmacological role of SDS and Rhodiola rosea in Chinese medicine. Our findings also support the use of SDS as an erythropoiesis-adjuvant agent to correct anemia and malhypoxia. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
C1 [Qian, Erin Wei; Ge, Daniel Tianfang; Kong, Siu-Kai] Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China.
C3 Chinese University of Hong Kong
RP Kong, SK (corresponding author), Chinese Univ Hong Kong, Dept Biochem, Shatin, Hong Kong, Peoples R China.
EM weiqian2007@yahoo.com.cn; tianfang.ge@umassmed.edu; skkong@cuhk.edu.hk
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NR 30
TC 52
Z9 61
U1 0
U2 24
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0378-8741
EI 1872-7573
J9 J ETHNOPHARMACOL
JI J. Ethnopharmacol.
PD JAN 27
PY 2011
VL 133
IS 2
BP 308
EP 314
DI 10.1016/j.jep.2010.09.025
PG 7
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 756IE
UT WOS:000290004100006
PM 20920561
DA 2026-05-27
ER

PT J
AU Ge, YL
   Zhang, B
   Song, JB
   Cao, QL
   Bu, YR
   Li, PJ
   Bai, YA
   Yang, CB
   Xie, MJ
AF Ge, Yiling
   Zhang, Bin
   Song, Jibo
   Cao, Qinglin
   Bu, Yingrui
   Li, Peijie
   Bai, Yungang
   Yang, Changbin
   Xie, Manjiang
TI Discovery of Salidroside as a Novel Non-Coding RNA Modulator to Delay
   Cellular Senescence and Promote BK-Dependent Apoptosis in
   Cerebrovascular Smooth Muscle Cells of Simulated Microgravity Rats
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE microgravity; non-coding RNAs; salidroside; cellular senescence;
   BK-dependent apoptosis
ID SPACEFLIGHT; HYPERTENSION; GRAVITATION; RESISTANCE; STIFFNESS; ARTERIES;
   MODEL
AB Cardiovascular aging has been reported to accelerate in spaceflights, which is a great potential risk to astronauts' health and performance. However, current exercise routines are not sufficient to reverse the adverse effects of microgravity exposure. Recently, salidroside (SAL), a valuable medicinal herb, has been demonstrated to display an important role for prevention and treatment in cardiovascular and other diseases. In the present work, Sprague-Dawley rats with four-week tail-suspension hindlimb-unloading were used to simulate microgravity effects on the cardiovascular system. We found that intragastrical administration of SAL not only significantly decreased the expressions of senescence biomarkers, such as P65 and P16, but also obviously increased the expressions of BK-dependent apoptotic genes, including the large-conductance calcium-activated K+ channel (BK), Bax, Bcl-2, and cleaved caspase-3, in vascular smooth muscle cells (VSMCs) in vivo and in vitro. In addition, relative non-coding RNAs were screened, and a luciferase assay identified that SAL increased apoptosis by activating LncRNA-FLORPAR, inhibiting miR-193, and then triggering the activity of the BK-alpha subunit. Our work indicated that SAL is a novel non-coding RNA modulator for regulating the LncRNA-FLORPAR sponging miR-193 pathway, which significantly promoted BK-dependent apoptosis and delayed cerebrovascular aging-like remodeling during simulated microgravity exposure. Our findings may provide a new approach to prevent cardiovascular aging in future spaceflights.
C1 [Ge, Yiling; Zhang, Bin; Song, Jibo; Cao, Qinglin; Bu, Yingrui; Li, Peijie; Bai, Yungang; Xie, Manjiang] Fourth Mil Med Univ, Dept Aerosp Physiol, Key Lab Aerosp Med, Minist Educ, Xian 710032, Peoples R China.
   [Yang, Changbin] Fourth Mil Med Univ, Mil Med Innovat Ctr, Xian 710032, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Xie, MJ (corresponding author), Fourth Mil Med Univ, Dept Aerosp Physiol, Key Lab Aerosp Med, Minist Educ, Xian 710032, Peoples R China.; Yang, CB (corresponding author), Fourth Mil Med Univ, Mil Med Innovat Ctr, Xian 710032, Peoples R China.
EM 15339046217@163.com; fmmuzhangbin@yeah.net; ssongjibo@163.com;
   caoqinglin@126.com; b99961008411@163.com; lpj6467@163.com;
   baiyun_1123@163.com; xbbyang@fmmu.edu.cn; xiemanjiang@fmmu.edu.cn
OI Yang, Changbin/0009-0007-6172-057X
FU The authors gratefully acknowledge the Air Force Medical University
   Doctoral Sustentation Fund and the First-rate Discipline Construction of
   Aerospace Medicine Project for support for this work.; Air Force Medical
   University Doctoral Sustentation Fund; First-rate Discipline
   Construction of Aerospace Medicine Project
FX The authors gratefully acknowledge the Air Force Medical University
   Doctoral Sustentation Fund and the First-rate Discipline Construction of
   Aerospace Medicine Project for support for this work.
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NR 45
TC 3
Z9 6
U1 0
U2 7
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD OCT
PY 2023
VL 24
IS 19
AR 14531
DI 10.3390/ijms241914531
PG 20
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA U0CP7
UT WOS:001081575900001
PM 37833978
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, X
   Zhang, YM
   Li, R
   Zhu, LP
   Fu, BQ
   Yan, TH
AF Zhang, Xue
   Zhang, Yiming
   Li, Rui
   Zhu, Lingpeng
   Fu, Buqing
   Yan, Tianhua
TI Salidroside ameliorates Parkinson's disease by inhibiting
   NLRP3-dependent pyroptosis
SO AGING-US
LA English
DT Article
DE pyroptosis; NLRP3; salidroside; Parkinson's disease; MPTP
ID NLRP3 INFLAMMASOME ACTIVATION; CELL-DEATH; TYROSINE-HYDROXYLASE;
   GASDERMIN-D; NEURONS; IMMUNE; MITOCHONDRIAL; DYSFUNCTION; AUTOPHAGY;
   TARGETS
AB Parkinson's disease (PD) is a common age-related neurodegenerative movement disorder, which is mainly due to the loss of dopaminergic neurons. Pyroptosis is a new programmed cell death characterized by NLR Family Pyrin Domain Containing 3 (NLRP3)-dependent, IL-1 beta, IL-18 and Gasdermin D. Salidroside (Sal) has been reported to have neuro-protective effect. However, the roles of pyroptosis and Sal on anti-pyroptosis in PD have not been elucidated. In this study, we tested underlying mechanisms of pyroptosis in PD and neuroprotective effects of Sal. We established 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced C57BL/6J mice and C57BL/10ScNJ (TLR4-deficient mice) in vivo, MPTP-induced PC-12 and LPS-induced BV2 in vitro. We found that Sal could ameliorate MPTP-induced PD symptoms and reduce the levels of IL-1 beta, IL-18 and Gasdermin D, which are main hallmarks of pyroptosis. Further study indicated that Sal alleviated PD through inhibiting NLRP3-dependent pyroptosis. In conclusion, pyroptosis plays a key role in PD and Sal protects dopaminergic neurons by inhibiting NLRP3-dependent pyroptosis through: (1) indirectly reducing the production of NLRP3, pro-IL-1 beta and pro-IL-18 by inhibiting TLR4/MyD88/NF-kappa B signaling pathways, (2) directly suppressing pyroptosis through inhibiting TXNIP/ NLRP3/caspase-1 signaling pathways. These results indicated that inhibiting pyroptosis or administration of Sal could be a novel therapeutic strategy for PD.
C1 [Zhang, Xue; Zhang, Yiming; Li, Rui; Yan, Tianhua] China Pharmaceut Univ, Dept Physiol, Sch Basic Med & Clin Pharm, Nanjing 210009, Peoples R China.
   [Fu, Buqing] Nanjing Univ Chinese Med, Affiliated Jiangsu Prov Hosp Chinese Med, Dept Inspect, Nanjing 210009, Peoples R China.
   [Zhu, Lingpeng] Nanjing Med Univ, Affiliated Wuxi Peoples Hosp, Ctr Clin Res, Wuxi 214023, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; Nanjing University of Chinese Medicine;
   Nanjing Medical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, Dept Physiol, Sch Basic Med & Clin Pharm, Nanjing 210009, Peoples R China.; Fu, BQ (corresponding author), Nanjing Univ Chinese Med, Affiliated Jiangsu Prov Hosp Chinese Med, Dept Inspect, Nanjing 210009, Peoples R China.; Zhu, LP (corresponding author), Nanjing Med Univ, Affiliated Wuxi Peoples Hosp, Ctr Clin Res, Wuxi 214023, Jiangsu, Peoples R China.
EM zhulingpeng2008@126.com; fu.buqing@163.com; tianhuayan0822edu@163.com
RI ; Su, Tianyuan/Y-7054-2019
OI Zhu, Lingpeng/0000-0003-0762-4038; Yan, Tianhua/0000-0001-6124-8630; 
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NR 74
TC 144
Z9 165
U1 1
U2 70
PU IMPACT JOURNALS LLC
PI ORCHARD PARK
PA 6666 E QUAKER ST, STE 1, ORCHARD PARK, NY 14127 USA
SN 1945-4589
J9 AGING-US
JI Aging-US
PD MAY 31
PY 2020
VL 12
IS 10
BP 9405
EP 9426
DI 10.18632/aging.103215
PG 22
WC Cell Biology; Geriatrics & Gerontology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Geriatrics & Gerontology
GA LU4HS
UT WOS:000537718700039
PM 32432571
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Zhou, WJ
   Chen, KQ
   Lu, Q
   Luo, YJ
   Zhang, C
   Zheng, Y
   Zhuo, ZW
   Guo, KH
   Wang, JH
   Chen, H
   Sha, WH
AF Zhou, Weijie
   Chen, Kequan
   Lu, Quan
   Luo, Yujun
   Zhang, Chen
   Zheng, Yue
   Zhuo, Zewei
   Guo, Kehang
   Wang, Jinghua
   Chen, Hao
   Sha, Weihong
TI The Protective Effect of Rosavin from Rhodiola rosea on
   Radiation-Induced Intestinal Injury
SO CHEMISTRY & BIODIVERSITY
LA English
DT Article
DE Rosavin; radiation-induced intestinal injury; anti-inflammation;
   antioxidant reaction
ID OXIDATIVE STRESS; CELLS; ANTIOXIDANT; ENTERITIS; ROOT; L.
AB Bioactive constituents from Rhodiola rosea L. (RRL) exhibit multiple pharmacological effects on diverse diseases. However, whether they are suitable for the treatment of radiation-induced intestinal injury (RIII) remains unclear. This study aims to investigate their roles and mechanisms in the RIII rat model. The radioprotective effects of the four bioactive constituents of RRL (salidroside, herbacetin, rosavin and arbutin) were evaluated by the cell viability of irradiated IEC-6 cells. Intestinal tissues were collected for histological analysis, localized inflammation and oxidative stress assessments. Our work showed that salidroside, rosavin and arbutin improved the cell viability of the irradiated IEC-6 cells, with the highest improvement in 12.5 mu M rosavin group. The rosavin treatment significantly improved survival rate and intestinal damage in irradiated rats by modulating the inflammatory response and oxidative stress. Our work indicated that rosavin may be the optimal constituent of RRL for RIII treatment, providing an attractive candidate for radioprotection.
C1 [Zhou, Weijie; Sha, Weihong] South China Univ Technol, Sch Med, Guangzhou 510030, Peoples R China.
   [Zhou, Weijie; Lu, Quan; Luo, Yujun; Zhang, Chen; Zheng, Yue; Zhuo, Zewei; Guo, Kehang; Chen, Hao; Sha, Weihong] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Gastroenterol, Guangzhou 510030, Peoples R China.
   [Chen, Kequan] Guangzhou Med Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou 510030, Peoples R China.
   [Wang, Jinghua] Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Hematol, Guangzhou 510030, Peoples R China.
C3 South China University of Technology; Southern Medical University -
   China; Guangdong Academy of Medical Sciences & Guangdong General
   Hospital; Guangzhou Medical University; Southern Medical University -
   China; Guangdong Academy of Medical Sciences & Guangdong General
   Hospital
RP Sha, WH (corresponding author), South China Univ Technol, Sch Med, Guangzhou 510030, Peoples R China.; Chen, H; Sha, WH (corresponding author), Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Gastroenterol, Guangzhou 510030, Peoples R China.; Wang, JH (corresponding author), Guangdong Acad Med Sci, Guangdong Prov Peoples Hosp, Dept Hematol, Guangzhou 510030, Peoples R China.
EM wangjinghua@gdph.org.cn; chenhao@gdph.org.cn; shaweihong@gdph.org.cn
RI zheng, yue/AAA-4479-2021; Zhuo, Zewei/MTF-8166-2025; Wang,
   Jing-hua/AAO-2350-2020; Zhou, Weijie/U-1680-2019; chen,
   kequan/OUI-4916-2025; Chen, Hao/AAV-8078-2021; guo, kehang/LMP-0392-2024
OI Luo, YuJun/0000-0002-5149-6451; 
FU National Natural Science Foundation of China [81300279, 81741067];
   Guangdong Province Natural Science Foundation [2016A030313815,
   2017A030313464]; Science and Technology Planning Project of Guangdong
   Province [2015A020212029]; Science and Technology Program of Guangzhou
   [201707010419, 201804010050]; Medical Scientific Research Foundation of
   Guangdong Province [A2019063]; Special Fund for Science and Technology
   of Guangdong Provincial People's Hospital/Guangdong Academy of Medical
   Sciences [2018bq01]; Fundamental Research Funds for the Central
   Universities [D2180600]; Scientific Research Project of Traditional
   Chinese Medicine Bureau of Guangdong Province [20201010]; High-level
   Hospital Construction Project [DFJH201803, KJ012019099, DFJH201923]
FX This work was supported by the National Natural Science Foundation of
   China (Grant Nos. 81300279 and 81741067), Guangdong Province Natural
   Science Foundation (Grant Nos. 2016A030313815 and 2017A030313464), the
   Science and Technology Planning Project of Guangdong Province (Grant No.
   2015A020212029), the Science and Technology Program of Guangzhou (Grant
   Nos. 201707010419 and 201804010050), the Medical Scientific Research
   Foundation of Guangdong Province (Grant No. A2019063), the Special Fund
   for Science and Technology of Guangdong Provincial People's
   Hospital/Guangdong Academy of Medical Sciences (Grant No. 2018bq01), the
   Fundamental Research Funds for the Central Universities (Grant No.
   D2180600), the Scientific Research Project of Traditional Chinese
   Medicine Bureau of Guangdong Province (Grant No. 20201010), and the
   High-level Hospital Construction Project (Grant Nos. DFJH201803,
   KJ012019099 and DFJH201923).
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NR 37
TC 17
Z9 24
U1 0
U2 41
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1612-1872
EI 1612-1880
J9 CHEM BIODIVERS
JI Chem. Biodivers.
PD DEC
PY 2020
VL 17
IS 12
DI 10.1002/cbdv.202000652
EA NOV 2020
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA PG5XI
UT WOS:000592223300001
PM 33089958
DA 2026-05-27
ER

PT J
AU Yu, X
   Sun, LL
   Tan, LJ
   Wang, M
   Ren, XL
   Pi, JX
   Jiang, MM
   Li, N
AF Yu, Xuan
   Sun, Lili
   Tan, Lejun
   Wang, Meng
   Ren, Xiaoliang
   Pi, Jiaxin
   Jiang, Miaomiao
   Li, Nan
TI Preparation and Characterization of PLGA-PEG-PLGA Nanoparticles
   Containing Salidroside and Tamoxifen for Breast Cancer Therapy
SO AAPS PHARMSCITECH
LA English
DT Article
DE salidroside; tamoxifen; PLGA; co-delivery; breast cancer
ID CO-DELIVERY; CONTROLLED-RELEASE; IN-VITRO; DRUG; BIOAVAILABILITY;
   NANOCARRIERS; NARINGENIN; MICELLES; SYSTEMS
AB Nanoparticles (NPs) containing the hydrophilic drug salidroside (Sal) and the hydrophobic drug tamoxifen (Tam) were prepared using a triblock copolymer poly(lactic-co-glycolic acid) (PLGA)-poly(ethylene glycol) (PEG)-PLGA to achieve synergism in the treatment of breast cancer. The double emulsion (w/o/w) method was used to prepare Sal-Tam NPs with an average particle size of 275.3 +/- 44.0 nm, a polydispersity index of 0.302 +/- 0.102, and a zeta potential of - 6.98 +/- 2.99. The entrapment efficiency of the hydrophilic and hydrophobic components was 32.63% +/- 0.73% and 49.18% +/- 3.04%, respectively. On differential scanning calorimetry, the NPs showed the amorphous nature of both Sal and Tam. The sustained release of Sal and Tam from the NPs was significantly prolonged under physiological conditions (pH 7.4). The CCK-8 assay using the 4T1 cell line revealed a 1.7-fold decrease in the IC50 value for Sal-Tam NPs when compared with free Tam. The in vivo anti-tumor effect was assessed in BALB/c mice, and the results demonstrated that these NPs decreased the tumor volume compared with saline and showed high anti-tumor activity. A pharmacokinetic study showed significant enhancement of the bioavailability of Tam in Sal-Tam NPs compared with free Tam in suspension. The intracellular and mitochondrial anti-oxidative effect of Sal was thought to be attributed to the promising anti-tumor effect of drug co-delivery. This study confirmed that the use of Sal-Tam NPs may be a promising approach in breast cancer therapy.
C1 [Yu, Xuan; Tan, Lejun; Wang, Meng; Pi, Jiaxin; Jiang, Miaomiao; Li, Nan] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 301617, Peoples R China.
   [Sun, Lili; Ren, Xiaoliang] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine
RP Wang, M (corresponding author), Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin 301617, Peoples R China.; Ren, XL (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 301617, Peoples R China.
EM wangmeng@tjutcm.edu.cn; renxiaoliang@tjutcm.edu.cn
RI Yu, Xuan/O-3449-2014
FU National Natural Science Foundation of China [81873191]
FX This work was supported by the grant from the National Natural Science
   Foundation of China (No. 81873191).
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NR 41
TC 34
Z9 42
U1 1
U2 69
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1530-9932
J9 AAPS PHARMSCITECH
JI AAPS PharmSciTech
PD JAN 29
PY 2020
VL 21
IS 3
AR 85
DI 10.1208/s12249-019-1523-8
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA KW6QQ
UT WOS:000521293900001
PM 31997020
DA 2026-05-27
ER

PT J
AU Chen, T
   Ma, ZQ
   Zhu, LP
   Jiang, WJ
   Wei, TT
   Zhou, R
   Luo, F
   Zhang, K
   Fu, Q
   Ma, CH
   Yan, TH
AF Chen, Tong
   Ma, Zhanqiang
   Zhu, Lingpeng
   Jiang, Wenjiao
   Wei, Tingting
   Zhou, Rui
   Luo, Fen
   Zhang, Kai
   Fu, Qiang
   Ma, Chunhua
   Yan, Tianhua
TI Suppressing Receptor-Interacting Protein 140: a New Sight for
   Salidroside to Treat Cerebral Ischemia
SO MOLECULAR NEUROBIOLOGY
LA English
DT Article
DE Salidroside; Cerebral ischemia; RIP140; Inflammation
ID ACUTE LUNG INJURY; NF-KAPPA-B; IN-VITRO; FOCAL ISCHEMIA; BRAIN-INJURY;
   P65 SUBUNIT; RAT MODEL; INFLAMMATION; MICE; EXPRESSION
AB The purpose of the current study was to detect the effect of salidroside (Sal) on cerebral ischemia and explore its potential mechanism. Middle cerebral artery occlusion (MCAO) was performed to investigate the effects of Sal on cerebral ischemia. The rats were randomly divided into five groups: sham group, vehicle group, clopidogrel (7.5 mg/kg) group, Sal (20 mg/kg) group, and Sal (40 mg/kg) group. SH-SY5Y cells were exposed to ischemia-reperfusion (I/R) injury to verify the protective effect of Sal in vitro. We also built the stable receptor-interacting protein 140 (RIP140)-overexpressing SH-SY5Y cells. The results showed that Sal significantly reduces brain infarct size and cerebral edema. Sal could effectively decrease the levels of interleukin-6 (IL-6), interleukin-1 beta (IL-1 beta), and tumor necrosis factor-alpha (TNF-alpha) in serum of the MCAO rats and supernatant of I/R-induced SH-SY5Y cells. Immunohistochemical and Western blot results demonstrated that Sal inhibited RIP140-mediated inflammation and apoptosis in the MCAO rats and SH-SY5Y cells. In addition, we further confirmed that RIP140/NF-kappa B signaling plays a crucial role by evaluating the protein expression in RIP140-overexpressing SH-SY5Y cells. Our findings suggested that Sal could be used as an effective neuroprotective agent for cerebral ischemia due to its significant effect on preventing neuronal cell injury after cerebral ischemia both in vivo and in vitro by the inhibitions of RIP140-mediated inflammation and apoptosis.
C1 [Chen, Tong; Jiang, Wenjiao; Wei, Tingting; Yan, Tianhua] China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.
   [Ma, Zhanqiang; Zhang, Kai; Fu, Qiang] China Pharmaceut Univ, Dept Pharmacol Chinese Mat Med, Nanjing 210009, Jiangsu, Peoples R China.
   [Zhu, Lingpeng; Zhou, Rui; Luo, Fen; Ma, Chunhua; Yan, Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University; China
   Pharmaceutical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, Nanjing 210009, Jiangsu, Peoples R China.; Ma, CH; Yan, TH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Peoples R China.
EM machuanhua25@126.com; yantianhuabest@126.com
RI Su, Tianyuan/Y-7054-2019; zhou, rui/KZT-9353-2024
FU Foundation for Science of Chinese Medicine; Foundation for Science of
   Integrated Chinese and Western Medicine; National Natural Science
   Foundation of China [81403041]; Natural Science Foundation of Jiangsu
   Province [BK20140961]; Priority Academic Program Development of Jiangsu
   Higher Education Institutions (PAPD); National Twelve Five Major Drug
   Discovery Project [2011ZX09102-002-01]
FX The study was supported by the Foundation for Science of Chinese
   Medicine, the Foundation for Science of Integrated Chinese and Western
   Medicine, the National Natural Science Foundation of China (81403041),
   the Natural Science Foundation of Jiangsu Province (BK20140961), the
   Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD), and the National Twelve Five Major Drug Discovery
   Project (no. 2011ZX09102-002-01).
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NR 39
TC 40
Z9 49
U1 0
U2 19
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0893-7648
EI 1559-1182
J9 MOL NEUROBIOL
JI Mol. Neurobiol.
PD NOV
PY 2016
VL 53
IS 9
BP 6240
EP 6250
DI 10.1007/s12035-015-9521-7
PG 11
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA EB2ZO
UT WOS:000387231300037
PM 26563497
DA 2026-05-27
ER

PT J
AU Zhao, ZR
   Zhao, D
   Su, LY
   Ding, MZ
   Zhang, M
   He, H
   Li, CB
AF Zhao, Zerun
   Zhao, Di
   Su, Liuyu
   Ding, Mengzhen
   Zhang, Miao
   He, Hui
   Li, Chunbao
TI Encapsulation and release of salidroside in myofibrillar protein-sodium
   alginate gel: Effects of different M/G ratios of sodium alginate
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
AB Myofibrillar protein-sodium alginate (MP-SA) gels play a pivotal role in the development of functional food gels. Salidroside (SAL) is promising component but suffers from low bioavailability, necessitating effective delivery systems. This study introduces M/G ratio factor into classical theoretical MP-based gel models, and use for the SAL delivery. The findings indicate that SA significantly enhances gel properties and functions. Scanning electron microscopy, liquid chromatography, and low-field nuclear magnetic resonance confirmed that the addition of SA improved microstructure, water retention, and thus reduced SAL loss during processing. Digestion simulations revealed the influence of SA type on SAL release kinetics. Molecular docking showed that SA with lower M/G ratio binds more readily to MP, a key determinant of gel performance. These insights provide a novel theoretical basis for MP-SA gels and offer a new perspective on the delivery of bioactive compounds in functional foods.
C1 [Zhao, Zerun; Zhao, Di; Su, Liuyu; Ding, Mengzhen; Zhang, Miao; He, Hui; Li, Chunbao] Nanjing Agr Univ, Coll Food Sci & Technol, Jiangsu Innovat Ctr Meat Prod Proc & Quality Contr, Key Lab Meat Proc,State Key Lab Meat Qual Control, Nanjing 210095, Peoples R China.
C3 Nanjing Agricultural University
RP Li, CB (corresponding author), Nanjing Agr Univ, Coll Food Sci & Technol, Nanjing 210095, Peoples R China.
EM chunbao.li@njau.edu.cn
RI Zhang, Miao/NUQ-0968-2025; zhao, di/OJT-2117-2025; Li,
   chunbao/KHD-9616-2024; He, Hui/GXZ-7211-2022; Ding,
   Mengzhen/GSI-9599-2022
OI Zhang, Miao/0009-0000-7626-983X; 
FU Ministry of Finance; Ministry of Agriculture and Rural Affairs [CARS 35]
FX This work was financially supported by the Ministry of Finance and the
   Ministry of Agriculture and Rural Affairs (CARS 35) .
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NR 39
TC 12
Z9 12
U1 15
U2 48
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD DEC
PY 2024
VL 282
AR 136811
DI 10.1016/j.ijbiomac.2024.136811
EA OCT 2024
PN 2
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA L1F6X
UT WOS:001348255200001
PM 39461650
DA 2026-05-27
ER

PT J
AU Panossian, A
   Hamm, R
   Wikman, G
   Efferth, T
AF Panossian, Alexander
   Hamm, Rebecca
   Wikman, Georg
   Efferth, Thomas
TI Mechanism of action of Rhodiola, salidroside, tyrosol and
   triandrin in isolated neuroglial cells: An interactive pathway analysis
   of the downstream effects using RNA microarray data
SO PHYTOMEDICINE
LA English
DT Article
DE Pharmacogenomics; Rhodiola rosea; Salidroside; Triandrin; Tyrosol
ID GENERALIZED ANXIETY DISORDER; CENTRAL-NERVOUS-SYSTEM; ROSEA L. EXTRACT;
   ADAPTOGENS EXERT; NEUROPEPTIDE-Y; DOUBLE-BLIND; STRESS; INHIBITION;
   EXPRESSION; PLACEBO
AB Aim: The aim of this study was to identify the targets (genes, interactive signaling pathways, and molecular networks) of Rhodiola rosea extract in isolated neuroglia cells and to predict the effects of Rhodiola extract on cellular functions and diseases. In addition, the potential mechanism of action of Rhodiola rosea extract was elucidated, and the "active principle" among the three isolated constituents (salidroside, triandrin, and tyrosol) was identified.
   Methods: Gene expression profiling was performed using the T98G human neuroglia cell line after treatment with the Rhodiola rosea SHR-5 extract and several of its individual constituents (salidroside, triandrin and tyrosol). An interactive pathway analysis of the downstream effects was performed using datasets containing significantly up- and down-regulated genes, and the effects on cellular functions and diseases were predicted.
   Results: In total, the expression of 1062 genes was deregulated by the Rhodiola extract (631 analyzed, 336 up-regulated, 295 down-regulated), and 1052, 1062, and 1057 genes were deregulated by salidroside, triandrin, and tyrosol, respectively. The analysis of the downstream effects shows that the most significant effects of Rhodiola are associated with cardiovascular (72 deregulated genes), metabolic (63 genes), gastrointestinal (163 genes), neurological (95 genes), endocrine (60 genes), behavioral (50 genes), and psychological disorders (62 genes).
   The most significantly affected canonical pathways across the entire dataset, which contains the 1062 genes deregulated by Rhodiola, were the following: (a) communication between innate and adaptive immune cells, (b) eNOS signaling, (c) altered T and B cell signaling in rheumatoid arthritis, (d) axonal guidance signaling, (e) G-protein coupled receptor signaling, (f) glutamate receptor signaling, (g) ephrin receptor signaling, (h) cAMP-mediated, and (i) atherosclerosis signaling pathways.
   Genes associated with behavior and behavioral diseases were identified within intracellular signaling pathways (d) through (h). The analysis of the downstream effects predicted decreases in emotional and aggressive behavior, which corroborates the results from preclinical and clinical studies of the use of Rhodiola for the treatment of depression and anxiety. Of the 17 genes that regulate emotional behavior, nine exhibit expression patterns that are consistent with decreases in emotional behavior (z-score -2.529), and all five relevant genes are expressed in a manner consistent with decreases in aggressive behavior (z-score -2.197). A decrease in seizures and infarct sizes and an increase in the chemotaxis of cells were predicted to accompany the decrease in emotional and aggressive behaviors.
   Conclusions: Rhodiola exhibits a multi-targeted effect on transcription to regulate the cellular response, affecting the various signaling pathways and molecular networks associated with beneficial effects on emotional behavior, particularly aggressive behavior, and with psychological, neurological, cardiovascular, metabolic, endocrine, and gastrointestinal disorders. Each of the purified compounds has its own pharmacological profile, which is both similar to and different from that of the total Rhodiola extract. In general, several compounds contribute to the specific cellular or/and physiological function of the extract in various diseases. (C) 2014 Elsevier GmbH. All rights reserved.
C1 [Panossian, Alexander; Wikman, Georg] Swedish Herbal Inst Res & Dev, SE-41262 Gothenburg, Sweden.
   [Hamm, Rebecca; Efferth, Thomas] Johannes Gutenberg Univ Mainz, Dept Pharmaceut Biol, Inst Pharm & Biochem, D-55122 Mainz, Germany.
C3 Johannes Gutenberg University of Mainz
RP Panossian, A (corresponding author), Swedish Herbal Inst Res & Dev, Grondalsgatan 11 A, SE-41262 Gothenburg, Sweden.
EM alexander.panossian@shi.se
RI ; Panossian, Alexander/AAK-8720-2021
OI Efferth, Thomas/0000-0002-3096-3292; Panossian,
   Alexander/0000-0002-8467-4525; Efferth, Thomas/0000-0002-2637-1681
FU Swedish Herbal Institute
FX This work was supported in part by the Swedish Herbal Institute (A.P.,
   G.W.). We are indebted to Dr. Tolga Eichhorn (Department of
   Pharmaceutical Biology, Institute of Pharmacy and Biochemistry,
   University of Mainz, Mainz Germany) for his scientific discussions.
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NR 48
TC 67
Z9 76
U1 0
U2 57
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD SEP 25
PY 2014
VL 21
IS 11
BP 1325
EP 1348
DI 10.1016/j.phymed.2014.07.008
PG 24
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA AP0HK
UT WOS:000341741900015
PM 25172797
DA 2026-05-27
ER

PT J
AU Tinsley, GM
   Jagim, AR
   Potter, GDM
   Garner, D
   Galpin, AJ
AF Tinsley, Grant M.
   Jagim, Andrew R.
   Potter, Gregory D. M.
   Garner, Dan
   Galpin, Andrew J.
TI Rhodiola rosea as an adaptogen to enhance exercise performance: a
   review of the literature
SO BRITISH JOURNAL OF NUTRITION
LA English
DT Review
DE Arctic root; Dietary supplement; Golden root; Physical performance;
   Rosavin; Roseroot; Salidroside
ID OXIDATIVE STRESS; MUSCLE DAMAGE; DOUBLE-BLIND; SUPPLEMENTATION; EXTRACT;
   ENDURANCE; FATIGUE; MITOCHONDRIA; SALIDROSIDE; MECHANISMS
AB Rhodiola rosea (RR) is a plant whose bioactive components may function as adaptogens, thereby increasing resistance to stress and improving overall resilience. Some of these effects may influence exercise performance and adaptations. Based on studies of rodents, potential mechanisms for the ergogenic effects of RR include modulation of energy substrate stores and use, reductions in fatigue and muscle damage and altered antioxidant activity. At least sixteen investigations in humans have explored the potential ergogenicity of RR. These studies indicate acute RR supplementation (similar to 200 mg RR containing similar to 1 % salidroside and -3 % rosavin, provided 60 min before exercise) may prolong time-to-exhaustion and improve time trial performance in recreationally active males and females, with limited documented benefits of chronic supplementation. Recent trials providing higher doses (similar to 1500 to 2400 mg RR/d for 4-30 d) have demonstrated ergogenic effects during sprints on bicycle ergometers and resistance training in trained and untrained adults. The effects of RR on muscle damage, inflammation, energy system modulation, antioxidant activity and perceived exertion are presently equivocal. Collectively, it appears that adequately dosed RR enhances dimensions of exercise performance and related outcomes for select tasks. However, the current literature does not unanimously show that RR is ergogenic. Variability in supplementation dose and duration, concentration of bioactive compounds, participant characteristics, exercise tests and statistical considerations may help explain these disparate findings. Future research should build on the longstanding use of RR and contemporary clinical trials to establish the conditions in which supplementation facilitates exercise performance and adaptations.
C1 [Tinsley, Grant M.] Texas Tech Univ, Dept Kinesiol & Sport Management, Lubbock, TX 79409 USA.
   [Jagim, Andrew R.] Mayo Clin Hlth Syst, Sports Med, La Crosse, WI USA.
   [Potter, Gregory D. M.] Greg Potter PhD Ltd, Brighton, E Sussex, England.
   [Garner, Dan; Galpin, Andrew J.] Biomol Athlete LLC, Wilmington, DE USA.
   [Galpin, Andrew J.] Calif State Univ, Ctr Sport Performance, Dept Kinesiol, Fullerton, CA USA.
C3 Texas Tech University System; Texas Tech University; California State
   University System; California State University Fullerton
RP Tinsley, GM (corresponding author), Texas Tech Univ, Dept Kinesiol & Sport Management, Lubbock, TX 79409 USA.
EM grant.tinsley@ttu.edu
RI Tinsley, Grant/S-4582-2019; Jagim, Andrew/Y-2447-2019
FU BioMolecular Athlete, LLC.
FX This work was financially supported by BioMolecular Athlete, LLC.
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NR 50
TC 35
Z9 43
U1 5
U2 30
PU CAMBRIDGE UNIV PRESS
PI CAMBRIDGE
PA EDINBURGH BLDG, SHAFTESBURY RD, CB2 8RU CAMBRIDGE, ENGLAND
SN 0007-1145
EI 1475-2662
J9 BRIT J NUTR
JI Br. J. Nutr.
PD FEB 14
PY 2024
VL 131
IS 3
BP 461
EP 473
DI 10.1017/S0007114523001988
EA AUG 2023
PG 13
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA ES9H5
UT WOS:001067840200001
PM 37641937
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Wang, ZY
   Liu, H
   Li, L
   Li, YC
   Yan, HY
   Yuan, Y
AF Wang, Ziyue
   Liu, Hui
   Li, Lu
   Li, Yucai
   Yan, Haiyang
   Yuan, Yuan
TI Modulation of Disordered Bile Acid Homeostasis and Hepatic Tight
   Junctions Using Salidroside against Hepatocyte Apoptosis in
   Furan-Induced Mice
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article; Early Access
DE furan; salidroside (SAL); apoptosis; metabolomic; bile acid homeostasis
ID INHIBITING APOPTOSIS; OXIDATIVE STRESS; GENE-EXPRESSION; RATS;
   CHOLESTEROL; RESPONSES; TOXICITY; INJURY
AB Furan, a processing-induced food contaminant, has attracted great attention due to its hepatotoxicity. To further investigate the underlying mechanism of salidroside (SAL) alleviating furan-induced liver damage, we divided Balb/c mice into the control group, the furan (8 mg/kg/day) group, and three groups of three different doses of SAL (10/20/40 mg/kg/day) in the current research. The shifted serum profile was observed through untargeted metabonomics, to which the bile acid metabolism was related, and the alleviating effect of SAL against furan-induced apoptosis was caused by the metabolism. Target bile acid quantification for the liver and serum showed that SAL positively regulated the homeostasis of bile acids disturbed by furan. Meanwhile, SAL significantly upregulated the synthesis genes of bile acids (Cyp7a1, Cyp7b1, Cyp8b1, and Cyp27a1) and the uptake transport genes (Ntcp and Oatps) and downregulated the efflux transport genes (Bsep, Ost-alpha, Ost-beta, Mrp2, and Mrp4). Transmission electron microscopy of the bile canaliculi and tight junctions and the levels of tight junction marker proteins (ZO-1, occludin, and claudin-1) confirmed that the disruption of the hepatic tight junction was inhibited by SAL. The connection between the apoptosis- and tight junction-related proteins was observed through the construction of a protein-protein interaction network. SAL suppressed the furan-induced hepatocyte apoptosis evidenced by the detection of TUNEL and Bax, Bcl-2, and caspase-3 levels. Taken together, SAL alleviated furan-induced hepatocyte apoptosis via altering the disordered homeostasis of bile acids and hepatic tight junctions.
C1 [Wang, Ziyue; Liu, Hui; Li, Lu; Li, Yucai; Yan, Haiyang; Yuan, Yuan] Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Peoples R China.
C3 Jilin University
RP Yuan, Y (corresponding author), Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Peoples R China.
EM yuan_yuan@jlu.edu.cn
FU National Natural Science Foundation of China [31972181]
FX ? ACKNOWLEDGMENTS The authors are grateful to the National Natural
   Science Foundation of China for providing the funds for this study (No.
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NR 59
TC 8
Z9 10
U1 1
U2 79
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD 2022 AUG 8
PY 2022
DI 10.1021/acs.jafc.2c04654
EA AUG 2022
PG 13
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 4X0RQ
UT WOS:000860559900001
PM 35939816
DA 2026-05-27
ER

PT J
AU Yu, S
   Cheng, Q
   Li, L
   Liu, M
   Yang, YM
   Ding, F
AF Yu, Shu
   Cheng, Qiong
   Li, Lu
   Liu, Mei
   Yang, Yumin
   Ding, Fei
TI 2-(4-Methoxyphenyl) ethyl-2-acetamido-2-deoxy-β-D-pyranoside confers
   neuroprotection in cell and animal models of ischemic stroke through
   calpain1/PKA/CREB-mediated induction of neuronal glucose transporter 3
SO TOXICOLOGY AND APPLIED PHARMACOLOGY
LA English
DT Article
DE 2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-beta-D-pyranoside; Ischemic
   stroke models; Neuroprotection; CREB; PKA; Neuronal glucose transporter
   3
ID DEPENDENT PROTEIN-KINASE; CEREBRAL-ISCHEMIA; NMDA RECEPTOR;
   HIPPOCAMPAL-NEURONS; INDUCED APOPTOSIS; RAT-BRAIN; IN-VIVO; CREB;
   SALIDROSIDE; EXPRESSION
AB Salidroside is proven to be a neuroprotective agent of natural origin, and its analog, 2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-beta-D-pyranoside (named SalA-4 g), has been synthesized in our lab. In this study, we showed that SalA-4 g promoted neuronal survival and inhibited neuronal apoptosis in primary hippocampal neurons exposed to oxygen and glucose deprivation (OGD) and in rats subjected to ischemia by transient middle cerebral artery occlusion (MCAO), respectively, and that SalA-4 g was more neuroprotective than salidroside. We further found that SalA-4g elevated glucose uptake in OGD-injured primary hippocampal neurons and increased the expression and recruitment of glucose transporter 3 (GLUT3) in ischemic brain. Signaling analysis revealed that SalA-4 g triggered the phosphorylation of CREB, and increased the expression of PM Rh in primary hippocampal neurons exposed to OGD injury, while inhibition of PKA/CREB by H-89 alleviated the elevation in glucose uptake and GLUT3 expression, and blocked the protective effects of SalA-4 g. Moreover, SalA-4 g was noted to inhibit intracellular Ca2+ influx and calpain1 activation in OGD-injured primary hippocampal neurons. Our results suggest that SalA-4 g neuroprotection might be mediated by increased glucose uptake and elevated GLUT3 expression through calpain1/PKA/CREB pathway. (C) 2014 Elsevier Inc. All rights reserved.
C1 [Yu, Shu; Cheng, Qiong; Li, Lu; Liu, Mei; Yang, Yumin; Ding, Fei] Nantong Univ, Coinnovat Ctr Neuroregenerat, Jiangsu Key Lab Neuroregenerat, Nantong 226001, JS, Peoples R China.
C3 Nantong University
RP Ding, F (corresponding author), Nantong Univ, Coinnovat Ctr Neuroregenerat, Jiangsu Key Lab Neuroregenerat, 19 Qixiu Rd, Nantong 226001, JS, Peoples R China.
EM dingfei@ntu.edu.cn
RI DING, FEI/KLD-8925-2024; Liu, Mei/K-9005-2019
OI Yu, Shu/0000-0003-3771-267X
FU National Key Basic Research Program of China (973 program)
   [2014CB542202]; National Natural Science Foundation of China [81371389,
   81171180, 81171457, 81371687]; Nantong Science and Technology Innovation
   Project [HS2013003]; Priority Academic Program Development of Jiangsu
   Higher Education Institutions (PAPD)
FX The authors thank Professor Jie Liu for assistance in manuscript
   preparation. This work was supported by the National Key Basic Research
   Program of China (973 program, grant no. 2014CB542202), National Natural
   Science Foundation of China (grant nos. 81371389, 81171180, 81171457,
   and 81371687), Nantong Science and Technology Innovation Project (grant
   no. HS2013003), and a Project Funded by the Priority Academic Program
   Development of Jiangsu Higher Education Institutions (PAPD).
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NR 44
TC 31
Z9 32
U1 0
U2 25
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0041-008X
EI 1096-0333
J9 TOXICOL APPL PHARM
JI Toxicol. Appl. Pharmacol.
PD JUN 15
PY 2014
VL 277
IS 3
BP 259
EP 269
DI 10.1016/j.taap.2014.03.025
PG 11
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA AH7WZ
UT WOS:000336347400004
PM 24726522
DA 2026-05-27
ER

PT J
AU Xu, HY
   Tang, XL
   Li, PF
   Zhang, DM
   Ta, G
   Lu, J
   Wang, J
AF Xu, Han-Ying
   Tang, Xiao-Lei
   Li, Peng-Fei
   Zhang, Dong-Mei
   Ta, Guang
   Lu, Jing
   Wang, Jian
TI Evaluating Salidroside as a Therapeutic Agent for Vascular Calcification
   Using Network Pharmacology and Experimental Rat Models
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID INFLAMMATION
AB Vascular calcification (VC) is a critical pathological condition associated with significant morbidity and mortality. This study employs a hybrid approach of network pharmacology and molecular biology to delineate the therapeutic mechanisms of salidroside (SAL), an active compound from Rhodiola crenulata, against VC. Through database mining and network analysis, 388 SAL targets intersecting with 2871 VC-associated targets were identified, resulting in 208 common targets. A protein-protein interaction (PPI) network constructed via the String database and topological analysis in Cytoscape 3.9.1 pinpointed 10 key targets, including IL6, TNF, TP53, IL1B, HIF1A, CASP3, and STAT3, among others. The identified genes were concentrated in the lipid and atherosclerosis pathways, indicating that the improvement of VC by SAL may occur through the regulation of abnormal expression of lipid and inflammatory factors. It was also found that SAL inhibits the abnormal expression of inflammatory factors, thereby activating the JAK2/STAT3 pathway to intervene in the progression of VC. The JAK2/STAT3 pathway is a key molecular mechanism by which SAL prevents further deterioration of VC. Functional enrichment analyses revealed the involvement of these targets in inflammatory responses and lipid metabolism, pivotal pathways in VC. In vivo studies in rats demonstrated SAL's efficacy in mitigating dyslipidemia and vascular inflammation, with improved serum lipid profiles and reduced vascular calcium deposition. The mechanistic exploration, grounded in Western blot analysis, demonstrated salidroside's ability to regulate the JAK2/STAT3 signaling pathway, highlighting its potential as a modulator in this critical molecular mechanism and offering a potential therapeutic target for VC. The strength of this research lies in its methodological rigor, integrating computational predictions with in vivo validations. This comprehensive approach establishes a robust framework for exploring the therapeutic mechanisms of natural compounds in combating VC.
C1 [Xu, Han-Ying; Wang, Jian] Changchun Univ Chinese Med, Affiliated Hosp, Dept Encephalopathy, Changchun, Peoples R China.
   [Tang, Xiao-Lei; Lu, Jing] Changchun Univ Chinese Med, Res Ctr Tradit Chinese Med, Affiliated Hosp, Changchun, Peoples R China.
   [Li, Peng-Fei] Changchun Univ Chinese Med, Affiliated Hosp, Dept Nephrol, Changchun, Peoples R China.
   [Zhang, Dong-Mei] Changchun Univ Chinese Med, Affiliated Hosp, Sci Res Off, Changchun, Peoples R China.
   [Ta, Guang] Changchun Univ Chinese Med, Affiliated Hosp, Rehabil Dept, Changchun, Peoples R China.
C3 Changchun University of Chinese Medicine; Changchun University of
   Chinese Medicine; Changchun University of Chinese Medicine; Changchun
   University of Chinese Medicine; Changchun University of Chinese Medicine
RP Wang, J (corresponding author), Changchun Univ Chinese Med, Affiliated Hosp, Dept Encephalopathy, Changchun, Peoples R China.; Lu, J (corresponding author), Changchun Univ Chinese Med, Res Ctr Tradit Chinese Med, Affiliated Hosp, Changchun, Peoples R China.; Ta, G (corresponding author), Changchun Univ Chinese Med, Affiliated Hosp, Rehabil Dept, Changchun, Peoples R China.
EM ta_guang@126.com; Jinglu198904@163.com; Jian_w222@163.com
FU Jilin Provincial Department of Science and Technology Project
   [YDZJ202301ZYTS460]; Jilin Provincial Department of Education Project
   [JJKH20230991KJ]
FX This work was financially supported by the Jilin Provincial Department
   of Science and Technology Project (YDZJ202301ZYTS460) , and Jilin
   Provincial Department of Education Project (JJKH20230991KJ) .
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NR 40
TC 2
Z9 2
U1 3
U2 5
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD JAN
PY 2025
IS 215
AR e67728
DI 10.3791/67728
PG 25
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 1WR2H
UT WOS:001475431300004
PM 39960197
DA 2026-05-27
ER

PT J
AU Ke, J
   Wang, J
   Wu, X
   Yan, YH
AF Ke, Jin
   Wang, Jie
   Wu, Xing
   Yan, Yuehua
TI Salidroside Ameliorates Ultraviolet-Induced Keratinocyte Injury by
   Inducing SIRT1-Dependent Autophagy
SO CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
LA English
DT Article
DE keratinocytes; salidroside; ultraviolet radiation; oxidative stress;
   autophagy; SIRT1
ID OXIDATIVE STRESS; PROTECTS SKIN; SENESCENCE; RADIATION; ACTIVATION;
   CANCER; DAMAGE; UVB
AB Introduction: Autophagy is an important process for maintaining intracellular homeostasis and is deregulated in ultraviolet B (UVB)-induced skin injury. Salidroside (SAL) is an active ingredient extracted from Rhodiola rosea, which is a herbal medicine that has shown protection against ultraviolet (UV) radiation. Here, we investigated the functions and mechanisms of SAL on UVB-induced skin cell oxidative damage and autophagy.Methods: Human immortalized keratinocyte cell line HaCaT was used as a cell model of UV injury. HaCaT cells were exposed to UVB irradiation and then incubated with SAL to investigate cell viability, lactate dehydrogenase (LSD) in culture media, intracellular reactive oxygen species (ROS) level, oxidative stress, autophagy, and regulatory effects on SIRT1 protein.Results: SAL pretreatment (25, 50 and 100 mu M) increased cell viability and inhibited LDH release in UVB-challenged HaCaT cells. SAL (100 mu M) significantly reduced intracellular ROS level and suppressed oxidative stress, with increased MDA content and increased SOD activity. In addition, SAL pretreatment enhanced autophagy in UVB-irradiated HaCaT cells, increased protein expressions of Beclin-1 and ATG7, and decreased protein expression of P62. We also found that pretreatment with SAL increased the SIRT1 protein in irradiated HaCaT cells. SAL protected UVB-induced damage in a dependent manner on autophagy and SIRT1, as SAL-induced increase in viability was significantly attenuated by specific autophagy inhibitor Wortmannin (1 mu M) or SIRT1 inhibitor EX-527 (100 nM).Discussion: The present study results speculate that SAL suppresses UVB-induced injury and autophagy by enhancing SIRT1 expression.
C1 [Ke, Jin; Wang, Jie; Wu, Xing; Yan, Yuehua] Fudan Univ, Shanghai Pudong Hosp, Dept Dermatol, Pudong Med Ctr, Shanghai 201399, Peoples R China.
   [Yan, Yuehua] Fudan Univ, Shanghai Pudong Hosp, Dept Dermatol, Pudong Med Ctr, 2800 Gongwei Rd, Shanghai 201399, Peoples R China.
C3 Fudan University; Fudan University
RP Yan, YH (corresponding author), Fudan Univ, Shanghai Pudong Hosp, Dept Dermatol, Pudong Med Ctr, 2800 Gongwei Rd, Shanghai 201399, Peoples R China.
EM yanyuehuash@163.com
FU Research Initiation Fund for Introducing Talents of Shanghai Pudong
   Hospital [YJRCJJ201802]
FX Funding This study was supported by Research Initiation Fund for
   Introducing Talents of Shanghai Pudong Hospital (Grant No: YJRCJJ201802)
   .
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NR 46
TC 9
Z9 9
U1 3
U2 41
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-7015
J9 CLIN COSMET INV DERM
JI CLIN. COSMET. INVESTIG. DERMATOL.
PY 2022
VL 15
BP 1499
EP 1508
DI 10.2147/CCID.S367233
PG 10
WC Dermatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Dermatology
GA 3N0AB
UT WOS:000835816200001
PM 35941856
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Jiang, YP
   Ye, RJ
   Yang, JM
   Liu, N
   Zhang, WJ
   Ma, L
   Sun, T
   Niu, JG
   Zheng, P
   Yu, JQ
AF Jiang, Ya-Ping
   Ye, Rui-Juan
   Yang, Jia-Mei
   Liu, Ning
   Zhang, Wen-Jin
   Ma, Lin
   Sun, Tao
   Niu, Jian-Guo
   Zheng, Ping
   Yu, Jian-Qiang
TI Protective effects of Salidroside on spermatogenesis in streptozotocin
   induced type-1 diabetic male mice by inhibiting oxidative stress
   mediated blood-testis barrier damage
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Salidroside; Diabetic mice; Spermatogenic dysfunction; Blood testis
   barrier; Oxidative stress
ID LYCIUM-BARBARUM POLYSACCHARIDE; MALE REPRODUCTIVE FUNCTION; SEXUAL
   DYSFUNCTION; SPERM QUALITY; ANTIOXIDANT; MELLITUS; APOPTOSIS; RATS;
   PERMEABILITY; METABOLISM
AB Spermatogenic dysfunction is one of the major secondary complications of male diabetes. Salidroside (SAL) is the important active ingredients isolated from Herba Cistanche, which exhibits numerous pharmacological activities such as antioxidant, anti-diabetic, and anti-inflammatory effects. The present study was designed to determine whether SAL contributes to the recovery from spermatogenic dysfunction in streptozotocin (STZ) induced type-1 diabetic mice. SAL (25, 50, or 100 mg/kg) and Clomiphene citrate (CC, 5 mg/kg) were orally administered to male type-1 diabetic mice for 10 weeks. Testis tissues were collected for histopathological and biochemical analysis. Moreover, reproductive organ weight, sperm parameters, and testicular cell DNA damage were estimated. The results revealed that SAL significantly improved the weight of the reproductive organs, sperm parameters and testicular morphology to different degrees in type-1 diabetic mice. Furthermore, reactive oxygen species (ROS) and malondialdehyde (MDA) levels were significantly reduced, and the activities of superoxide dismutase (SOD), catalase (CAT), and glutathione (GSH), markedly increased in the testicular tissue after SAL treatment. In addition, our data also showed a marked downregulation the fluorescence expressions of p38 MAPK phosphorylation and upregulation the protein expressions of ZO-1, Occludin, Claudin-11 and N-cadherin after SAL administration (100 mg/kg) compared with the type-1 diabetic group. In conclusion, these results demonstrated that SAL exerts protective effects on type-1 diabetes-induced male spermatogenic dysfunction, which is likely mediated by inhibiting oxidative stress-mediated blood testis barrier damage.
C1 [Jiang, Ya-Ping; Ye, Rui-Juan; Yang, Jia-Mei; Liu, Ning; Zhang, Wen-Jin; Zheng, Ping; Yu, Jian-Qiang] Ningxia Med Univ, Dept Pharmacol, Yinchuan 750004, Ningxia Hui Aut, Peoples R China.
   [Ma, Lin; Sun, Tao; Niu, Jian-Guo] Ningxia Med Univ, Ningxia Key Lab Craniocerebral Dis Ningxia Hui Au, Yinchuan 750004, Ningxia Hui Aut, Peoples R China.
   [Yu, Jian-Qiang] Ningxia Med Univ, Ningxia Hui Med Modern Engn Res Ctr, Yinchuan 750004, Ningxia Hui Aut, Peoples R China.
   [Yu, Jian-Qiang] Ningxia Med Univ, Collaborat Innovat Ctr, Yinchuan 750004, Ningxia Hui Aut, Peoples R China.
C3 Ningxia Medical University; Ningxia Medical University; Ningxia Medical
   University; Ningxia Medical University
RP Zheng, P; Yu, JQ (corresponding author), Ningxia Med Univ, Dept Pharmacol, Yinchuan 750004, Ningxia Hui Aut, Peoples R China.; Niu, JG (corresponding author), Ningxia Med Univ, Ningxia Key Lab Craniocerebral Dis Ningxia Hui Au, Yinchuan 750004, Ningxia Hui Aut, Peoples R China.
EM YujqLab@163.com; zhengping2004@126.com; nxmcnjg@163.com
RI wenjin, zhang/AAD-8101-2019
OI wenjin, zhang/0000-0002-3541-7282; Sun, Tao/0000-0001-8062-3432; Ma,
   Lin/0009-0002-7947-9597
FU Natural Science Foundation of China [81660261]; Key Research &
   Development projects in Ningxia Hui Autonomous region [2018BEG03013];
   major research and construction programs of Ningxia Province [2017BY079]
FX This work was supported by the Natural Science Foundation of China
   (grant number 81660261); Key Research & Development projects in Ningxia
   Hui Autonomous region (grant number 2018BEG03013) and the major research
   and construction programs of Ningxia Province (2017BY079).
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PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD JAN 5
PY 2020
VL 315
AR 108869
DI 10.1016/j.cbi.2019.108869
PG 15
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA KN1AT
UT WOS:000514572800009
PM 31682803
DA 2026-05-27
ER

PT J
AU Chauhan, K
   Kaur, G
   Kaur, S
AF Chauhan, Kalpana
   Kaur, Gurpreet
   Kaur, Sukhbir
TI Evaluation of antileishmanial efficacy of Salidroside against the
   SSG-sensitive and resistant strain of Leishmania donovani
SO PARASITOLOGY INTERNATIONAL
LA English
DT Article
DE Salidroside; Leishmania donovani; Immunomodulatory; SSG-sensitive;
   SSG-resistant strain; iNOS; NF-kappa B
ID MURINE VISCERAL LEISHMANIASIS; IMMUNE-RESPONSE; NITRIC-OXIDE; KAPPA-B;
   ACTIVATION; ANTIMONIATE; PROTECTION; INFECTION; APOPTOSIS; CELLS
AB The successful control and eradication of leishmaniasis are still challenging in view of the lack of adequate chemotherapy and potential prophylaxis. Research is going on for finding an appropriate anti-leishmanial drug which should be acceptable in terms of cost and safety. In view of this, the current study investigated the anti-leishmanial efficacy of salidroside (SAL) which is a phenylpropanoid glycoside. The leishmanicidal capacity of SAL was verified in vitro as well as in vivo. The SAL exhibited leishmanicidal activity against the promastigotes of L. donovani which was further validated by propidium iodide staining and its ability to arrest the promastigotes at the sub G(0)/G(1) stage. SAL decreased and controlled the VL infection in mice as estimated by real-time PCR. Active immunomodulation was exhibited upon SAL treatment in BALB/c mice. The characteristic features like pronounced DTH reaction, polarization of immune status to Th1 type of immune response, increased the production of CD4(+) and CD8(+) T cells indicated the immune-stimulatory property of SAL. In addition to this the expression of NF-kappa B, iNOS genes along with the levels of leishmanicidal species, NO and ROS were found to be augmented in SAL treated infected animals. Moreover, SAL exhibited minimal toxicity to the THP-1 cells and it revealed no toxicity against liver and kidney. The capability of SAL in promoting the immune status in favor of host during VL infection without causing any side-effects may be used as an effective strategy to fight the disease.
C1 [Chauhan, Kalpana; Kaur, Gurpreet; Kaur, Sukhbir] Panjab Univ, Dept Zool, Chandigarh, India.
C3 Panjab University
RP Kaur, S (corresponding author), Panjab Univ, Dept Zool, Parasitol Lab, Chandigarh, India.
EM puzoology@yahoo.com
OI Kaur, Sukhbir/0000-0001-9071-7950; , Kalpana Chauhan/0009-0005-3025-994X
FU Department of Science and Technology, India under INSPIRE Fellowship
   programme [DST/INSPIRE Fellowship/2013/1158]; DST-PURSE-grant of Panjab
   University, Chandigarh
FX This work received financial assistance from Department of Science and
   Technology, India, (No, DST/INSPIRE Fellowship/2013/1158), under INSPIRE
   Fellowship programme and DST-PURSE-grant of Panjab University,
   Chandigarh.
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NR 51
TC 17
Z9 18
U1 0
U2 16
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 1383-5769
J9 PARASITOL INT
JI Parasitol. Int.
PD OCT
PY 2019
VL 72
AR 101928
DI 10.1016/j.parint.2019.101928
PG 13
WC Parasitology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Parasitology
GA IN9SC
UT WOS:000479017700002
PM 31108221
DA 2026-05-27
ER

PT J
AU Xue, XH
   Feng, ZH
   Li, ZX
   Pan, XY
AF Xue, Xing-He
   Feng, Zhen-Hua
   Li, Zhen-Xing
   Pan, Xiao-Yun
TI Salidroside inhibits steroid-induced avascular necrosis of the femoral
   head via the PI3K/Akt signaling pathway: In vitro and in
   vivo studies
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE steroid-induced avascular necrosis of the femoral head; osteoblast;
   apoptosis; salidroside; phosphoinositide 3-kinase; protein kinase B
   signaling pathway
ID INDUCED APOPTOSIS; CELL-DEATH; INDUCED OSTEONECROSIS; STEM-CELLS; BONE;
   OSTEOBLASTS; ACTIVATION; PROTECTS; GLUCOCORTICOIDS; PROLIFERATION
AB Dexamethasone (Dex) and other glucocorticoids are widely used to treat serious infections and immunological diseases, however they may cause steroid-induced avascular necrosis of the femoral head (SANFH). Salidroside (Sal) has demonstrated an anti-apoptotic effect on neurocytes by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (Akt) signaling pathway. In the present study, primary osteoblasts were used in vitro and in rats in vivo to determine the anti-apoptotic effect of Sal on SANFH. The result of the present study demonstrated that pretreatment with Sal increased the cell survival rate while decreasing the cell apoptosis and lactate dehydrogenase release rate. Additionally, Sal also caused the reduction of TUNEL positive cells in TUNEL staining assay. Sal decreased the expression of cleaved caspase-3, cleaved caspase-9, apoptosis regulator BAX and cytochrome C, while it increased the expression of B cell lymphoma-2 and phosphorylated-Akt in Dex-induced osteoblasts. In vivo Sal protected against SANFH in rats by decreasing the percentage of empty lacunae. The present study demonstrated that Sal alleviated Dex-induced osteoblast apoptosis by activating the PI3K/Akt signaling pathway and downregulating caspase-3 expression in osteoblasts. Sal also protected against SANFH in a rat model of SANFH by decreasing the percentage of empty lacunae. The inhibition of the mitochondrial apoptosis pathway was also involved. Further research is required to determine the full underlying mechanisms by which Sal has an effect.
C1 [Pan, Xiao-Yun] Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed, 109 Xueyuan Xi Rd, Wenzhou 325000, Zhejiang, Peoples R China.
   [Pan, Xiao-Yun] Wenzhou Med Univ, Yuying Childrens Hosp, 109 Xueyuan Xi Rd, Wenzhou 325000, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University
RP Pan, XY (corresponding author), Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed, 109 Xueyuan Xi Rd, Wenzhou 325000, Zhejiang, Peoples R China.; Pan, XY (corresponding author), Wenzhou Med Univ, Yuying Childrens Hosp, 109 Xueyuan Xi Rd, Wenzhou 325000, Zhejiang, Peoples R China.
EM starriver789@163.com
OI Xue, Xinghe/0000-0003-3300-7287
FU Zhejiang Province Public Welfare Technology Application Research
   Project, China [2015C33209]; Wenzhou Public Welfare Science and
   Technology Project, Zhejiang Province, China [Y20150243]
FX The authors thank the staff of the Laboratory of the Orthopaedic
   Research Institute and the Scientific Research Center of the Second
   Affiliated Hospital of Wenzhou Medical University. The present study was
   generously supported by grants from the Zhejiang Province Public Welfare
   Technology Application Research Project, China (2015C33209) and Wenzhou
   Public Welfare Science and Technology Project, Zhejiang Province, China
   (Y20150243).
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NR 42
TC 27
Z9 37
U1 1
U2 20
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD MAR
PY 2018
VL 17
IS 3
BP 3751
EP 3757
DI 10.3892/mmr.2017.8349
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA FV2MB
UT WOS:000424400000039
PM 29286130
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Wu, D
   Yang, XY
   Zheng, T
   Xing, SS
   Wang, JH
   Chi, JY
   Bian, F
   Li, WJ
   Xu, G
   Bai, XL
   Wu, GJ
   Jin, S
AF Wu, Dan
   Yang, Xiaoyan
   Zheng, Tao
   Xing, Shasha
   Wang, Jianghong
   Chi, Jiangyang
   Bian, Fang
   Li, Wenjing
   Xu, Gao
   Bai, Xiangli
   Wu, Guangjie
   Jin, Si
TI A novel mechanism of action for salidroside to alleviate diabetic
   albuminuria: effects on albumin transcytosis across glomerular
   endothelial cells
SO AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
LA English
DT Article
DE albumin; transcytosis; salidroside; glomerular endothelial cell;
   diabetic nephropathy
ID ACTIVATED PROTEIN-KINASE; LOW-DOSE REGIMEN; OXIDATIVE STRESS;
   KIDNEY-DISEASE; RHODIOLA-ROSEA; CANCER-CELLS; DOUBLE-BLIND; IN-VIVO;
   METFORMIN; NEPHROPATHY
AB Salidroside (SAL) is a phenylethanoid glycoside isolated from the medicinal plant Rhodiola rosea. R. rosea has been reported to have beneficial effects on diabetic nephropathy (DN) and high-glucose (HG)-induced mesangial cell proliferation. Given the importance of caveolin-1 (Cav-1) in transcytosis of albumin across the endothelial barrier, the present study was designed to elucidate whether SAL could inhibit Cav-1 phosphorylation and reduce the albumin transcytosis across glomerular endothelial cells (GECs) to alleviate diabetic albuminuria as well as to explore its upstream signaling pathway. To assess the therapeutic potential of SAL and the mechanisms involved in DN albuminuria, we orally administered SAL to db/db mice, and the effect of SAL on the albuminuria was measured. The albumin transcytosis across GECs was explored in a newly established in vitro cellular model. The ratio of albumin to creatinine was significantly reduced upon SAL treatment in db/db mice. SAL decreased the albumin transcytosis across GECs in both normoglycemic and hyperglycemic conditions. SAL reversed the HG-induced downregulation of AMP-activated protein kinase and upregulation of Src kinase and blocked the upregulation Cav-1 phosphorylation. Meanwhile, SAL decreased mitochondrial superoxide anion production and moderately depolarized mitochondrial membrane potential. We conclude that SAL exerts its proteinuria-alleviating effects by downregulation of Cav-1 phosphorylation and inhibition of albumin transcytosis across GECs. These studies provide the first evidence of interference with albumin transcytosis across GECs as a novel approach to the treatment of diabetic albuminuria.
C1 [Wu, Dan; Yang, Xiaoyan; Zheng, Tao; Xing, Shasha; Wang, Jianghong; Chi, Jiangyang; Bian, Fang; Li, Wenjing; Xu, Gao; Bai, Xiangli; Wu, Guangjie; Jin, Si] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pharmacol, Wuhan 430074, Hubei, Peoples R China.
   [Wu, Dan; Yang, Xiaoyan; Zheng, Tao; Xing, Shasha; Wang, Jianghong; Chi, Jiangyang; Bian, Fang; Li, Wenjing; Xu, Gao; Bai, Xiangli; Wu, Guangjie; Jin, Si] Key Lab Drug Target Res & Pharmacodynam Evaluat H, Wuhan, Hubei, Peoples R China.
   [Wu, Dan; Jin, Si] Huazhong Univ Sci & Technol, Tongji Med Coll, Liyuan Hosp, Inst Geriatr Med,Dept Endocrinol, Wuhan 430074, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Jin, S (corresponding author), Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pharmacol, Wuhan 430074, Hubei, Peoples R China.
EM Jinsi@mail.hust.edu.cn
RI jin, si/KGK-5977-2024; Zheng, Tao/JOZ-1467-2023; xing,
   shasha/JFB-2393-2023
OI jin, si/0000-0003-0727-6715; Zheng, Tao/0000-0003-1742-1357; 
FU National Natural Science Foundation of China [81373413, 81072634,
   81573432, 81470458, 81070190]; Ministry of Education of China
   [NCET-10-0409, 2015ZHYX006]
FX This study was funded by the National Natural Science Foundation of
   China (81373413, 81072634, 81573432, 81470458, and 81070190) and grants
   from the Ministry of Education of China (NCET-10-0409, 2015ZHYX006).
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NR 43
TC 42
Z9 45
U1 0
U2 40
PU AMER PHYSIOLOGICAL SOC
PI BETHESDA
PA 9650 ROCKVILLE PIKE, BETHESDA, MD 20814 USA
SN 0193-1849
EI 1522-1555
J9 AM J PHYSIOL-ENDOC M
JI Am. J. Physiol.-Endocrinol. Metab.
PD FEB 1
PY 2016
VL 310
IS 3
BP E225
EP E237
DI 10.1152/ajpendo.00391.2015
PG 13
WC Endocrinology & Metabolism; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Physiology
GA DC2ZN
UT WOS:000369088200005
PM 26646098
DA 2026-05-27
ER

PT J
AU Wang, XH
   Qian, J
   Meng, Y
   Wang, P
   Cheng, RZ
   Zhou, GX
   Zhu, SX
   Liu, C
AF Wang, Xiaohong
   Qian, Jing
   Meng, Yun
   Wang, Ping
   Cheng, Ruizhi
   Zhou, Guoxiong
   Zhu, Shunxing
   Liu, Chun
TI Salidroside ameliorates severe acute pancreatitis-induced cell injury
   and pyroptosis by inactivating Akt/NF-κB and caspase-3/GSDME pathways
SO HELIYON
LA English
DT Article
DE Salidroside; Severe acute pancreatitis; Pyroptosis; Inflammation; Akt;
   NF; B; Caspase-3; GSDME
ID INDUCED BRAIN-INJURY; PROTEASE ACTIVATION; ACINAR-CELL; INFLAMMATION;
   MODEL
AB Our previous studies showed that Salidroside (Sal), a glucoside of the phenylpropanoid tyrosol isolated from Rhodiola rosea L, alleviated severe acute pancreatitis (SAP) by inhibiting inflam-mation. However, the detailed mechanism remains unclear. Recent evidence has indicated a critical role of Sal in ameliorating inflammatory disorders by regulating pyroptosis. The present study aimed to explore the involvement of Sal and pyroptosis in the pathogenesis of SAP and investigate the potential mechanism. The effects of Sal on pyroptosis were first evaluated using SAP rat and cell model. Our results revealed that Sal treatment significantly decreased SAP -induced pancreatic cell damage and pyroptosis in vivo and in vitro, as well as reduced the release of lactate dehydrogenase (LDH), IL-1 beta and IL-18. Search Tool for Interacting Chemicals (STITCH) online tool identified 4 genes (CASP3, AKT1, HIF1A and IL10) as candidate targets of Sal in both rattus norvegicus and homo sapiens. Western blot and immunohistochemistry staining validated that Sal treatment decreased the phosphorylation levels of Akt and NF-kappa B p65, as well as cleaved caspase-3 and N-terminal fragments of GSDME (GSDME-N), suggesting that Sal might suppress pyroptosis through inactivating Akt/NF-kappa B and Caspase-3/GSDME pathways. Further-more, overexpression of AKT1 or CASP3 could partially reverse the inhibitory effects of Sal on cell injury and pyroptosis, while downregulation of AKT1 or CASP3 promoted the inhibitory effects of Sal. Taken together, our data indicate that Sal suppresses SAP-induced pyroptosis through inac-tivating Akt/NF-kappa B and Caspase-3/GSDME pathways.
C1 [Wang, Xiaohong; Meng, Yun; Wang, Ping; Cheng, Ruizhi] Nanjing Drum Tower Hosp Grp, Yizheng Hosp, Dept Gastroenterol, Yizheng 211900, Jiangsu, Peoples R China.
   [Qian, Jing] Nanjing Drum Tower Hosp Grp, Yizheng Hosp, Dept Gen Surg, Yizheng 211900, Jiangsu, Peoples R China.
   [Zhou, Guoxiong] Nantong Univ, Affiliated Hosp, Dept Gastroenterol, Nantong 226001, Jiangsu, Peoples R China.
   [Zhu, Shunxing; Liu, Chun] Nantong Univ, Lab Anim Ctr, Nantong 226001, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University
RP Wang, XH (corresponding author), Nanjing Drum Tower Hosp Grp, Yizheng Hosp, Dept Gastroenterol, Yizheng 211900, Jiangsu, Peoples R China.
EM wx102474wx@163.com
RI Wang, Xiaohong/JXL-8370-2024; Wang, Ping/GZB-2001-2022
FU Traditional Chinese Medicine Technology Development Plan Project of
   Jiangsu Province [YB2020088]; Key R&D Projects in Yangzhou City
   [YZ2021091]; Health Innovation Project of Lvyang Jinfeng Plan of
   Yangzhou City [YZLYJF2020WSCX037]
FX Dr. Xiaohong Wang was supported by the Traditional Chinese Medicine
   Technology Development Plan Project of Jiangsu Province in 2020
   [YB2020088] , the Key R&D Projects in Yangzhou City in 2021 (Social
   Development) [YZ2021091] , and the Health Innovation Project of Lvyang
   Jinfeng Plan of Yangzhou City in 2020 [YZLYJF2020WSCX037].
CR Cai YW, 2022, FRONT AGING NEUROSCI, V13, DOI 10.3389/fnagi.2021.809433
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NR 49
TC 21
Z9 23
U1 4
U2 29
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD FEB
PY 2023
VL 9
IS 2
AR e13225
DI 10.1016/j.heliyon.2023.e13225
EA FEB 2023
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA E1BX7
UT WOS:000972985300001
PM 36747537
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, T
   Zhang, W
   Kang, XG
   Yang, RX
   Li, RR
   Huang, L
   Chen, JZ
   Yang, Q
   Sun, XL
AF Li, Tao
   Zhang, Wei
   Kang, Xiaogang
   Yang, Ruixin
   Li, Ruru
   Huang, Lu
   Chen, Jianzong
   Yang, Qian
   Sun, Xiaolong
TI Salidroside protects dopaminergic neurons by regulating the
   mitochondrial MEF2D-ND6 pathway in the MPTP/MPP+-induced
   model of Parkinson's disease
SO JOURNAL OF NEUROCHEMISTRY
LA English
DT Article
DE MEF2D; mitochondria; ND6; Parkinson's disease; salidroside
ID SURVIVAL FACTOR MEF2D; COMPLEX-I; RESPIRATORY-CHAIN; OXIDATIVE STRESS;
   NEUROTOXIN; DYSFUNCTION; MORPHOLOGY; LIVE
AB Mitochondrial complex I damage and oxidative stress play critical roles in the degeneration of dopaminergic (DA) neurons during the progression of Parkinson's disease (PD). Our previous study showed that NADH dehydrogenase 6 (ND6), exclusively regulated by mitochondrial myocyte enhancer factor 2D (MEF2D), was critical for mitochondrial complex I assembly. Recently, we found that Salidroside (Sal), isolated from Rhodiola rosea L., protected DA neurons by regulating oxidative stress-related mitochondrial pathways. Here, we investigated whether the mitochondrial MEF2D-ND6 pathway was involved in the neuroprotective effects of Sal. Our results showed that in 1-methyl-4-phenylpyridinium (MPP+)-injured SN4741 cells, Sal pretreatment improved cellular viability, inhibited apoptosis, and restored both the mitochondrial membrane potential and complex I activity. Similarly, the protective effects of Sal on mitochondrial complex I activity, DA neurons, and behavior were also confirmed in 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP)-lesioned mice. Besides, Sal pretreatment restored the expression of mitochondrial MEF2D and ND6 in MPP+-injured SN4741 cells and MPTP-lesioned mice. Finally and interestingly, the protective effects of Sal were not observed in cells transfected with Mt2Ddn, a specific blocker of mitochondrial MEF2D function, suggesting that Sal protects DA neurons primarily by regulating the mitochondrial MEF2D-ND6 pathway. Our study sheds light upon the protective role of Sal through targeting the mitochondrial MEF2D-ND6 pathway in regulations of mitochondrial function and DA neuronal viability, providing novel mechanistic insights into the neuroprotective effects of Sal against PD.
C1 [Li, Tao; Zhang, Wei; Li, Ruru; Chen, Jianzong] Fourth Mil Med Univ, Res Ctr Tradit Chinese Med, Xijing Hosp, Xian, Shaanxi, Peoples R China.
   [Kang, Xiaogang] Fourth Mil Med Univ, Xijing Hosp, Dept Neurol, Xian, Shaanxi, Peoples R China.
   [Yang, Ruixin; Huang, Lu; Yang, Qian] Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian 710038, Shaanxi, Peoples R China.
   [Sun, Xiaolong] Fourth Mil Med Univ, Xijing Hosp, Dept Rehabil Med, Xian 710032, Shaanxi, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Air Force
   Medical University; Air Force Medical University
RP Yang, Q (corresponding author), Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian 710038, Shaanxi, Peoples R China.; Sun, XL (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Dept Rehabil Med, Xian 710032, Shaanxi, Peoples R China.
EM qia-nyang@fmmu.edu.cn; xlsun@fmmu.edu.cn
RI ; Li, Tao/LJM-1988-2024; yang, qian/HTS-5357-2023
OI Sun, Xiaolong/0000-0002-0467-8332; Li, Tao/0000-0003-4512-2215; 
FU National Natural Science Foundation of China [81173590, 81802229]; Young
   Elite Scientists Sponsorship Program by CAST [2018QNRC001]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81173590 and 81802229), and Young Elite Scientists
   Sponsorship Program by CAST (2018QNRC001). Qian Yang is an editor with
   Journal of Neurochemistry. The other authors declare no conflict of
   interest.
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NR 43
TC 28
Z9 31
U1 0
U2 25
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0022-3042
EI 1471-4159
J9 J NEUROCHEM
JI J. Neurochem.
PD APR
PY 2020
VL 153
IS 2
BP 276
EP 289
DI 10.1111/jnc.14868
EA OCT 2019
PG 14
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA LF1UD
UT WOS:000492685300001
PM 31520529
OA Bronze
DA 2026-05-27
ER

PT J
AU Zhu, J
   Li, L
   Luan, YT
   Zhang, ZQ
   Wang, Y
   Xu, ZY
AF Zhu, Jie
   Li, Liang
   Luan, Yuting
   Zhang, Ziqing
   Wang, Yi
   Xu, Zhenyu
TI Salidroside Pre-Treatment Inhibits Hypertensive Renal Injury and
   Fibrosis Through Inhibiting Wnt/β-Catenin Pathway
SO DOSE-RESPONSE
LA English
DT Article
DE hypertensive renal injury; salidroside; angiotensin II; pre-treatment;
   Wnt/beta-catenin; ROS
ID NF-KAPPA-B; OXIDATIVE STRESS; KIDNEY INJURY; ACTIVATION; MECHANISMS;
   APOPTOSIS; ROLES; WNT
AB Objectives This study aimed to explore the protective effects and underlying mechanisms of salidroside (SAL) in angiotensin II (Ang II)-induced hypertensive renal injury and fibrosis, using in vivo and in vitro models. Methods In this study, we generated Ang II-induced hypertensive renal injury and fibrosis in mice and the recombinant interferon-gamma (IFN-gamma)-stimulated murine podocyte clone 5 (MPC5) model in vitro. Histological and oxidative stress analyses were performed to evaluate the renal injury. Results SAL pre-treatment reduced systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), and attenuated serum creatinine (Scr), blood urea nitrogen (BUN), and serum cystatin C (Cys-C) levels in Ang II-infused mice (all, P < 0.001). SAL reduced renal fibrosis and related molecules expression, including Collagen I, Collagen III, and alpha-smooth muscle actin (alpha-SMA) (all, P < 0.001). SAL decreased the content of malondialdehyde (MDA) while increasing superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px) in Ang II-treated mice (all, P < 0.001). In addition, SAL pre-treatment inhibited AT1R, Wnt1, Wnt3a, and beta-catenin expressions (all, P < 0.001), both in vivo and in vitro. Conclusion Our experimental data demonstrate that SAL pre-treatment protects against Ang II-induced hypertensive renal injury and fibrosis by suppressing the Wnt/beta-catenin pathway in vivo and in vitro.
C1 [Zhu, Jie; Li, Liang; Zhang, Ziqing; Wang, Yi; Xu, Zhenyu] Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Dept Emergency Med, 358 Datong Rd, Shanghai 200137, Peoples R China.
   [Luan, Yuting] Shanghai Univ Tradit Chinese Med, Dept Infect Dis, Peoples Hosp 7, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Wang, Y; Xu, ZY (corresponding author), Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Dept Emergency Med, 358 Datong Rd, Shanghai 200137, Peoples R China.
EM Xzy2062@163.com
RI wang, yi/OVX-8970-2025
FU Key Specialty Construction Project of Pudong Health and Family Planning
   Commission of Shanghai [PWZzk2022-15]; Shanghai Seventh People's
   Hospital "Beidou Star" Talent Training Project [BDX2021-03]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This work
   was supported by the Key Specialty Construction Project of Pudong Health
   and Family Planning Commission of Shanghai (Grant No. PWZzk2022-15).
   Shanghai Seventh People's Hospital "Beidou Star" Talent Training Project
   (BDX2021-03).
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NR 44
TC 0
Z9 0
U1 0
U2 3
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1559-3258
J9 DOSE-RESPONSE
JI Dose-Response
PD OCT
PY 2024
VL 22
IS 4
AR 15593258241298045
DI 10.1177/15593258241298045
PG 13
WC Pharmacology & Pharmacy; Radiology, Nuclear Medicine & Medical Imaging;
   Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Radiology, Nuclear Medicine & Medical Imaging;
   Toxicology
GA L3Y1W
UT WOS:001350102600001
PM 39506979
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, JY
   Guo, YJ
   Yang, YM
   Zhu, LP
   Yan, TH
   Miao, MX
AF Liu Jingyan
   Guo Yujuan
   Yang Yiming
   Zhu Lingpeng
   Yan Tianhua
   Miao Mingxing
TI Salidroside Attenuates LPS-Induced Acute Lung Injury in Rats
SO INFLAMMATION
LA English
DT Article
DE salidroside; LPS; lung injury; caveolin-1; TLR/NF-kappa B
ID MOUSE MODEL; IN-VITRO; PATHWAY; INFLAMMATION; APOPTOSIS; CELLS;
   DYSFUNCTION; POLYDATIN; TARGET; ROLES
AB The purpose of the present study was to investigate the effects of salidroside (Sal) on lung injury in lipopolysaccharide (LPS)-induced endotoxemic in vitro and in vivo. SD rats were randomly divided into five groups: control group, LPS group (15 mg kg(-1)), LPS plus dexamethasone (2 mg kg(-1)), and LPS plus Sal groups with different Sal doses (20 mg kg(-1), 40 mg kg(-1)). Wet-to-dry weight (W/D) ratio was performed. Hematoxylin-eosin (HE) staining of lung was performed. Lung level of myeloperoxidase (MPO) was measured. Serum levels of the activities of the anti-oxidant superoxide dismutase (SOD), glutathione peroxidase (GSH-px), glutathione (GSH), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) were measured. Caveolin-1 and TLR/NF-kappa B pathway proteins were detected by Western blot. In vitro, we evaluated the protective effect of Sal on A549 cell line induced by LPS. The activities of the antioxidant SOD, CAT, GSH and GPX, TNF-alpha, IL-6, and IL-1 beta in cellular supernatant were measured. Caveolin-1 and TLR/NF-kappa B pathway was examined by Western blot. As a result, Sal significantly attenuated the above indices. In addition, Sal exerts pronounced protective effects in rats subjected to LPS possibly through inhibiting the caveolin-1 and TLR/NF-kappa B pathway in vivo. Our results indicated that Sal could be a potential therapeutic agent for the treatment of lung injury disease.
C1 [Liu Jingyan; Guo Yujuan; Yang Yiming; Zhu Lingpeng; Yan Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Jiangsu, Peoples R China.
   [Miao Mingxing] China Pharmaceut Univ, Natl Expt Teaching Demonstrat Ctr Pharm, Nanjing, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Jiangsu, Peoples R China.; Miao, MX (corresponding author), China Pharmaceut Univ, Natl Expt Teaching Demonstrat Ctr Pharm, Nanjing, Jiangsu, Peoples R China.
EM yantianhuabest@126.com; mmx0224@cpu.edu.cn
RI Su, Tianyuan/Y-7054-2019
OI Yan, Tianhua/0000-0001-6124-8630
FU National Twelve Five Major Drug Discovery Project [2011ZX09102-002-01]
FX This work was supported by the National Twelve Five Major Drug Discovery
   Project (2011ZX09102-002-01).
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NR 32
TC 24
Z9 26
U1 1
U2 28
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD OCT
PY 2017
VL 40
IS 5
BP 1520
EP 1531
DI 10.1007/s10753-017-0593-6
PG 12
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA FG0RA
UT WOS:000409472600005
PM 28526985
DA 2026-05-27
ER

PT J
AU Zhu, Y
   Zhang, YJ
   Liu, WW
   Shi, AW
   Gu, N
AF Zhu, Yao
   Zhang, Ya-Jie
   Liu, Wei-Wei
   Shi, Ai-Wu
   Gu, Ning
TI Salidroside Suppresses HUVECs Cell Injury Induced by Oxidative Stress
   through Activating the Nrf2 Signaling Pathway
SO MOLECULES
LA English
DT Article
DE salidroside; oxidative stress; nuclear factor E2-related factor 2; heme
   oxygenase-1; NAD(P)H dehydrogenase (quinone1); human umbilical vein
   endothelial cells
ID ENDOTHELIAL DYSFUNCTION; ANTIOXIDANT ENZYMES; KAPPA-B; EXPRESSION;
   GLUTATHIONE; MECHANISMS; PROTECTS; H2O2; MOLECULES; RESPONSES
AB Oxidative stress plays an important role in the pathogenesis of cardiovascular diseases. Salidroside (SAL), one of the main effective constituents of Rhodiola rosea, has been reported to suppress oxidative stress-induced cardiomyocyte injury and necrosis by promoting transcription of nuclear factor E2-related factor 2 (Nrf2)-regulated genes such as heme oxygenase-1 (HO-1) and NAD(P)H dehydrogenase (quinone1) (NQO1). However, it has not been indicated whether SAL might ameliorate endothelial injury induced by oxidative stress. Here, our study demonstrated that SAL might suppress HUVEC cell injury induced by oxidative stress through activating the Nrf2 signaling pathway. The results of our study indicated that SAL decreased the levels of intercellular reactive oxygen species (ROS) and malondialdehyde (MDA), and improved the activities of superoxide dismutase (SOD) and catalase (CAT), resulting in protective effects against oxidative stress-induced cell damage in HUVECs. It suppressed oxidative stress damage by inducing Nrf2 nuclear translocation and activating the expression of Nrf2-regulated antioxidant enzyme genes such as HO-1 and NQO1 in HUVECs. Knockdown of Nrf2 with siRNA abolished the cytoprotective effects against oxidative stress, decreased the expression of Nrf2, HO-1, and NQO1, and inhibited the nucleus translocation of Nrf2 in HUVECs. This study is the first to demonstrate that SAL suppresses HUVECs cell injury induced by oxidative stress through activating the Nrf2 signaling pathway.
C1 [Zhu, Yao; Liu, Wei-Wei] Nanjing Univ Tradit Chinese Med, Coll Clin Med 1, Nanjing 210023, Jiangsu, Peoples R China.
   [Zhang, Ya-Jie; Gu, Ning] Nanjing Hosp Tradit Chinese Med, Nanjing 210001, Jiangsu, Peoples R China.
   [Shi, Ai-Wu] Nanjing Matern & Child Hlth Care Hosp, Nanjing 210004, Jiangsu, Peoples R China.
C3 Nanjing University of Chinese Medicine
RP Gu, N (corresponding author), Nanjing Hosp Tradit Chinese Med, Nanjing 210001, Jiangsu, Peoples R China.; Shi, AW (corresponding author), Nanjing Matern & Child Hlth Care Hosp, Nanjing 210004, Jiangsu, Peoples R China.
EM zy_njtcm@126.com; zhangyajie_jack@126.com; cheeseweiweiliu@126.com;
   shiaiwu888@163.com; jsguning@163.com
RI 张, 亚杰/J-6726-2017; Liu, Weiwei/KGL-0142-2024; Zhang, Yajie/J-6726-2017
OI 张, 亚杰/0000-0003-2510-6015; 
FU National Natural Science Foundation of China [81173399]; Natural science
   foundation of JiangSu Province [BK20161115]; Nanjing' Key Projects of
   Medical Science and Technology [201405042, ZKX14042]
FX This work was supported by National Natural Science Foundation of China
   (No. 81173399), Natural science foundation of JiangSu Province (No.
   BK20161115), and Nanjing' Key Projects of Medical Science and Technology
   (No. 201405042, ZKX14042). We thank Wei-Na Zhu, Jie Ruan, and Hong-Yan
   Long, Department of Central Laboratory, Nanjing Hospital of Traditional
   Chinese Medicine, for their instructive advice and useful suggestions.
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NR 51
TC 62
Z9 69
U1 2
U2 44
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD AUG
PY 2016
VL 21
IS 8
AR 1033
DI 10.3390/molecules21081033
PG 15
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA DU6ON
UT WOS:000382334600072
PM 27517893
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Ren, WP
   Huang, YT
   Meng, S
   Cao, ZJ
   Qin, NN
   Zhao, JK
   Huang, T
   Guo, XD
   Chen, X
   Zhou, ZJ
   Zhu, Y
   Yu, LM
   Wang, HS
AF Ren, Wenpu
   Huang, Yuting
   Meng, Shan
   Cao, Zijun
   Qin, Nana
   Zhao, Jikai
   Huang, Tao
   Guo, Xiaodong
   Chen, Xin
   Zhou, Zijun
   Zhu, Yan
   Yu, Liming
   Wang, Huishan
TI Salidroside treatment decreases the susceptibility of atrial
   fibrillation in diabetic mice by reducing mTOR-STAT3-MCP-1 signaling and
   atrial inflammation
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Atrial fibrillation; Salidroside; mTOR; Type 2 diabetes mellitus; MCP-1
ID MONOCYTE CHEMOATTRACTANT PROTEIN-1; CHEMOKINE RECEPTOR; DOWN-REGULATION;
   PATHWAY; CELLS; ACTIVATION; EXPRESSION; INSULIN
AB Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in clinic, and type 2 diabetes mellitus (T2DM) is an independent risk factor for AF. Salidroside (Sal), the active ingredient of the Rhodiola rosea, has hypoglycemic, anti-inflammatory, anti-fibrotic and anti-arrhythmic effects. The aim of this study is to investigate the effects and underlying molecular mechanisms of Sal on T2DM associated atrial inflammation and the pathogenesis of AF. In the in vivo study, T2DM mice model was established by high-fat diet and intraperitoneal injection of streptozotocin (STZ). Sal (25 mg/kg/d, 50 mg/kg/d, and 100 mg/kg/d) was administered orally for 4 weeks. T2DM caused atrial electrical and structural remodeling and significantly increased the susceptibility of AF. Meanwhile, mTOR-STAT3-MCP-1 signaling and inflammatory markers were also significantly enhanced in diabetic atria. However, Sal dose-dependently ameliorated cardiac dysfunction, mitigated atrial structural and electrical remodeling, and reduced atrial inflammation. Moreover, Sal-treated group exhibited remarkably down-regulated activity of mTOR-STAT3-MCP-1 pathway, and decreased atrial monocyte/macrophage infiltration. In palmitic acid (PA)-challenged HL-1 cells, Sal attenuated cytotoxicity, downregulated the expressions of TNF-alpha, IL-6, MCP-1, and inhibited the activation of mTOR-STAT3 signaling. However, co-treatment with MHY1485 (a mTOR agonist) reversed these effects. Taken together, the present study demonstrates that Sal treatment decreases the susceptibility of AF in diabetic mice by reducing mTOR-STAT3-MCP-1 signaling and atrial monocyte/macrophage infiltration. Sal treatment may represent a novel preventive therapy for cardiac arrhythmia and atrial fibrillation in diabetic patients.
C1 [Ren, Wenpu; Huang, Yuting; Meng, Shan; Cao, Zijun; Qin, Nana; Zhao, Jikai; Huang, Tao; Guo, Xiaodong; Chen, Xin; Zhou, Zijun; Zhu, Yan; Yu, Liming; Wang, Huishan] Gen Hosp Northern Theater Command, Dept Cardiovasc Surg, State Key Lab Frigid Zone Cardiovasc Dis, 83 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.
   [Ren, Wenpu; Cao, Zijun; Qin, Nana] Liaoning Univ Tradit Chinese Med, Shenyang 110847, Liaoning, Peoples R China.
   [Meng, Shan; Chen, Xin] Jinzhou Med Univ, Jinzhou 121001, Liaoning, Peoples R China.
C3 Liaoning University of Traditional Chinese Medicine; Jinzhou Medical
   University
RP Zhu, Y; Yu, LM; Wang, HS (corresponding author), Gen Hosp Northern Theater Command, Dept Cardiovasc Surg, State Key Lab Frigid Zone Cardiovasc Dis, 83 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China.
EM medzhuyan@163.com; lmyu2012@163.com; huishanw@126.com
RI Zhou, Zijun/ABC-6760-2021; Zhao, Jikai/KYQ-4681-2024
OI , 秦娜娜/0009-0000-5757-6535
FU National Natural Science Foundation of China [82170328, 82070239,
   82300356]; LiaoNing Revitalization Talents Program [XLYC2203006];
   Shenyang Science and Technology Project [22-321-33-36]; Natural Science
   Foundation of Liaoning Province [2023-MSLH-349, 2023-MSLH-365]
FX This study is supported by the funds from the National Natural Science
   Foundation of China (82170328, 82070239, 82300356), the LiaoNing
   Revitalization Talents Program (XLYC2203006), Shenyang Science and
   Technology Project (22-321-33-36) and the Natural Science Foundation of
   Liaoning Province (2023-MSLH-349, 2023-MSLH-365) .
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PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD DEC 5
PY 2024
VL 142
AR 113196
DI 10.1016/j.intimp.2024.113196
EA SEP 2024
PN B
PG 15
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA H2G7K
UT WOS:001321680500001
PM 39306893
DA 2026-05-27
ER

PT J
AU Lu, SJ
   Ji, N
   Wang, W
   Lin, XQ
   Gao, DS
   Geng, DQ
AF Lu, Shujin
   Ji, Niu
   Wang, Wei
   Lin, Xiaoqian
   Gao, Dianshuai
   Geng, Deqin
TI Salidroside improves cognitive function in Parkinson's disease via
   Braf-mediated mitogen-activated - activated protein kinase signaling
   pathway
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Salidroside; Parkinson's disease; Cognitive function; RNA sequencing;
   Metabolites
ID NEUROTROPHIC FACTOR
AB Objective: To delve into the underlying mechanism of Salidroside (Sal) on the improvement of cognitive function in Parkinson's Disease (PD). Methods: The experimental mice were divided into Control group, Model group [injected with 1-methyl-4phenyl-1,2,3,6-tetrahydropyridine (MPTP)], and Model+Sal +Sal (low concentration, high concentration) group. Mouse hippocampal tissues were extracted for RNA sequencing to obtain the core pathway and core gene. Mouse plasma was prepared and analyzed by LC-MS to obtain differential metabolites. In vitro experiments were verified by immunofluorescence and lentiviral transduction. Results: ELISA signaled that Sal facilitated the reduction of neuronal damage and inflammatory reaction in mice. MPTP_Sal_Low and MPTP_Sal_High groups had high levels of glial cell derived neurotrophie factor (GDNF) expression. Differentially expressed genes (DEGs) in control group, MPTP group and MPTP_Sal_High group were identified by transcriptomic, which were classified to the mitogen-activated protein kinase (MAPK) signaling pathway, and the core gene Braf was obtained. Metabolomics manifested that the differential metabolites involved DL-tyrosine, adenosine, phosphoenolpyruvate, and L-tryptophan. In vitro experiments verified that treatment inhibited the up-regulation of p-p38, p-c-Jun N-terminal kinase (JNK), and p-extracellular signal regulated kinase (ERK) expression, and growth of neuronal protrusions. The OE-Braf group showed a significant up-regulation of the GDNF expression, a decrease in the expression of p-p38, p-JNK, and p-ERK, and significant growth of neuronal protrusions. Conclusion: Sal may exert its effects in PD through the Braf-mediated MAPK signaling pathway, which can crease GDNF expression and promote neuronal protrusion growth for the protection of neurological function and the improvement of cognitive function.
C1 [Lu, Shujin; Ji, Niu; Gao, Dianshuai; Geng, Deqin] Nanjing Med Univ, 101 Longmian Ave, Nanjing 211166, Jiangsu, Peoples R China.
   [Lu, Shujin; Lin, Xiaoqian; Geng, Deqin] Xuzhou Med Univ, Affiliated Hosp, Dept Neurol, Xuzhou 221002, Jiangsu, Peoples R China.
   [Ji, Niu] Lianyungang First Peoples Hosp, Dept Neurol, Lianyungang 222000, Jiangsu, Peoples R China.
   [Wang, Wei] Xuzhou Med Univ, Affiliated Hosp, Dept Radiol, Xuzhou 221002, Jiangsu, Peoples R China.
   [Gao, Dianshuai] Xuzhou Med Univ, Sch Basic Med Sci, Xuzhou 221004, Jiangsu, Peoples R China.
C3 Nanjing Medical University; Xuzhou Medical University; Xuzhou Medical
   University; Xuzhou Medical University
RP Gao, DS; Geng, DQ (corresponding author), Nanjing Med Univ, 101 Longmian Ave, Nanjing 211166, Jiangsu, Peoples R China.
EM DianshuaiGao@outlook.com; gengdeqin@126.com
RI /AAP-6308-2021
FX The authors declare that they have no known competing financial
   interests or personal relationships that could have appeared to
   influence the work reported in this paper.
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NR 43
TC 6
Z9 7
U1 3
U2 16
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD AUG
PY 2024
VL 177
AR 116968
DI 10.1016/j.biopha.2024.116968
EA JUN 2024
PG 15
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA I9R6M
UT WOS:001333555100001
PM 38901199
OA gold
DA 2026-05-27
ER

PT J
AU Tian, F
   Chen, ZH
   Zhang, Y
   Jiang, J
   Li, T
AF Tian, Fei
   Chen, Zhihong
   Zhang, Ying
   Jiang, Jian
   Li, Tang
TI RETRACTED: Salidroside protects LPS-induced injury in human thyroid
   follicular epithelial cells by upregulation of MiR-27a (Retracted
   article. See vol. 299, 2022)
SO LIFE SCIENCES
LA English
DT Article; Retracted Publication
DE Hypothyroidism; Salidroside; miR-27a; Notch; NF-kappa B
ID CYCLIN D1; INFLAMMATORY RESPONSE; DOWN-REGULATION; TNF-ALPHA; IN-VITRO;
   KAPPA-B; PATHWAY; PROGRESSION; ACTIVATION; APOPTOSIS
AB Aims: Hypothyroidism is a common endocrine disease without standard treatment. Salidroside (SAL) has various positive biological activities. In this study, experiments were performed to investigate whether SAL had protective effects on LPS-induced cell inflammatory injury.
   Main methods: The human thyroid follicular epithelial cells (Nthy-ori 3-1) stimulated by LPS were treated with SAL and/or transfected with miR-27a inhibitor. Cell viability and cell apoptosis were detect by Cell Counting Kit-8 assay and flow cytometry, respectively. The expression of Cyclin D1 and apoptosis-related proteins, Notch proteins and NF-kappa B pathways related proteins were all measured by western blot. The expression of miR-27a and inflammatory chemokines MCP-1, IL-6 and TNF-alpha was examined by qRT-PCR. The protein weight of MCP-1, IL-6 and TNF-alpha was detected by ELISA.
   Key findings: LPS treatment induced cell injury by decreasing cell viability, and inducing cell apoptosis and inflammatory chemokines MCP-1, IL-6 and TNF-alpha. In addition, SAL alleviated LPS-induced cell injury by increasing cell viability, and decreasing cell apoptosis and inflammatory chemokines MCP-1, IL-6 and TNF-alpha. SAL upregulated miR-27a expression and further study showed that miR-27a downregulation impaired the protective effects of SAL. SAL downregulated the expression of Notch1/2, and phosphorylation of p65 and I kappa B alpha.
   Significance: SAL protects against LPS-induced injury in human thyroid follicular epithelial cells by upregulation of miR-27a. This process might be via inactivating Notch and NF-kappa B pathways.
C1 [Tian, Fei; Chen, Zhihong; Zhang, Ying] Qingdao Univ, Affiliated Hosp, Dept Neuroendocrine Pediat, Qingdao 266003, Peoples R China.
   [Jiang, Jian] Qingdao Univ, Affiliated Hosp, Dept Pediat Hematol, Qingdao 266003, Peoples R China.
   [Li, Tang] Qingdao Women & Childrens Hosp, Dept Endocrinol Pediat, 6 Tongfu Rd, Qingdao 266034, Peoples R China.
C3 Qingdao University; Qingdao University
RP Li, T (corresponding author), Qingdao Women & Childrens Hosp, Dept Endocrinol Pediat, 6 Tongfu Rd, Qingdao 266034, Peoples R China.
EM litang213@sina.com
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NR 37
TC 10
Z9 11
U1 0
U2 18
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0024-3205
EI 1879-0631
J9 LIFE SCI
JI Life Sci.
PD NOV 15
PY 2018
VL 213
BP 1
EP 8
DI 10.1016/j.lfs.2018.10.006
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA GY2ZM
UT WOS:000448413900001
PM 30300656
DA 2026-05-27
ER

PT J
AU Liu, X
   Wen, SR
   Yan, F
   Liu, K
   Liu, LQ
   Wang, L
   Zhao, SF
   Ji, XM
AF Liu, Xiangrong
   Wen, Shaohong
   Yan, Feng
   Liu, Kuan
   Liu, Liqiang
   Wang, Lei
   Zhao, Shangfeng
   Ji, Xunming
TI Salidroside provides neuroprotection by modulating microglial
   polarization after cerebral ischemia
SO JOURNAL OF NEUROINFLAMMATION
LA English
DT Article
DE Salidroside; Inflammation; Microglia; Polarization; Neuron; Stroke;
   Oligodendrocyte
ID MICROGLIA/MACROPHAGE POLARIZATION; ARTERY OCCLUSION; M2 MICROGLIA;
   CELL-DEATH; INJURY; RAT; NEURONS; INFLAMMATION; DEFICITS; NEUROGENESIS
AB Background: Following stroke, microglia can be driven to the "classically activated" pro-inflammatory (M1) phenotype and the "alternatively activated" anti-inflammatory (M2) phenotype. Salidroside (SLDS) is known to inhibit inflammation and to possess protective effects in neurological diseases, but to date, the exact mechanisms involved in these processes after stroke have yet to be elucidated. The purpose of this study was to determine the effects of SLDS on neuroprotection and microglial polarization after stroke.
   Methods: Male adult C57/BL6 mice were subjected to focal transient cerebral ischemia followed by intravenous SLDS injection. The optimal dose was determined by evaluation of cerebral infarct volume and neurological functions. RT-PCR and immunostaining were performed to assess microglial polarization. A transwell system and a direct-contact coculture system were used to elucidate the effects of SLDS-induced microglial polarization on oligodendrocyte differentiation and neuronal survival.
   Results: SLDS significantly reduced cerebral infarction and improved neurological function after cerebral ischemia. SLDS treatment reduced the expression of M1 microglia/macrophage markers and increased the expression of M2 microglia/macrophage markers after stroke and induced primary microglia from M1 phenotype to M2 phenotype. Furthermore, SLDS treatment enhanced microglial phagocytosis and suppressed microglial-derived inflammatory cytokine release. Cocultures of oligodendrocytes and SLDS-treated M1 microglia resulted in increased oligodendrocyte differentiation. Moreover, SLDS protected neurons against oxygen glucose deprivation by promoting microglial M2 polarization.
   Conclusions: These data demonstrate that SLDS protects against cerebral ischemia by modulating microglial polarization. An understanding of the mechanisms involved in SLDS-mediated microglial polarization may lead to new therapeutic opportunities after stroke.
C1 [Liu, Xiangrong; Wen, Shaohong; Liu, Kuan; Liu, Liqiang; Wang, Lei; Ji, Xunming] Capital Med Univ, Xuanwu Hosp, China Amer Inst Neurosci, Beijing 100053, Peoples R China.
   [Liu, Xiangrong; Wen, Shaohong; Yan, Feng; Liu, Kuan; Liu, Liqiang; Wang, Lei; Ji, Xunming] Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing 100053, Peoples R China.
   [Yan, Feng; Liu, Kuan; Liu, Liqiang] Capital Med Univ, Cerebrovasc Dis Res Inst, Xuanwu Hosp, Beijing 100053, Peoples R China.
   [Zhao, Shangfeng] Capital Univ Med Sci, Dept Neurosurg, Beijing Tongren Hosp, Beijing 100073, Peoples R China.
   [Ji, Xunming] Capital Univ Med Sci, Xuanwu Hosp, Dept Neurosurg, Beijing 100053, Peoples R China.
   [Ji, Xunming] Capital Med Univ, Cerebrovasc Dis Res Inst, Xuanwu Hosp, 45 Changchun St, Beijing 100053, Peoples R China.
C3 Capital Medical University; Capital Medical University; Capital Medical
   University; Capital Medical University; Capital Medical University
RP Ji, XM (corresponding author), Capital Med Univ, Xuanwu Hosp, China Amer Inst Neurosci, Beijing 100053, Peoples R China.; Ji, XM (corresponding author), Beijing Key Lab Translat Med Cerebrovasc Dis, Beijing 100053, Peoples R China.; Ji, XM (corresponding author), Capital Univ Med Sci, Xuanwu Hosp, Dept Neurosurg, Beijing 100053, Peoples R China.; Ji, XM (corresponding author), Capital Med Univ, Cerebrovasc Dis Res Inst, Xuanwu Hosp, 45 Changchun St, Beijing 100053, Peoples R China.
EM jixm@ccmu.edu.cn
RI ; Zhao, Songfeng/JFJ-4645-2023; Ji, Xunming/AAN-3370-2021
OI yan, feng/0000-0001-8663-6859; 
FU National Natural Science Foundation of China [81471209, 81641055,
   81000504]; Beijing Natural Science Foundation [7132112]; Distinguished
   Professor of Cheung Kong Scholars Program [T2014251]
FX This work was supported by the National Natural Science Foundation of
   China (grant No. 81471209, 81641055, 81000504 to XL), Beijing Natural
   Science Foundation (grant No. 7132112 to XL), and Distinguished
   Professor of Cheung Kong Scholars Program (grant No. T2014251 to XJ).
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NR 40
TC 138
Z9 161
U1 1
U2 37
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1742-2094
J9 J NEUROINFLAMM
JI J. Neuroinflamm.
PD FEB 9
PY 2018
VL 15
AR 39
DI 10.1186/s12974-018-1081-0
PG 11
WC Immunology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Neurosciences & Neurology
GA FW2BQ
UT WOS:000425106600003
PM 29426336
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liang, CX
   Qi, DL
   Zhang, LN
   Lu, P
   Liu, ZD
AF Liang Chun-Xia
   Qi Dong-Li
   Zhang Li-Na
   Lu Peng
   Liu Zhi-Dong
TI Preparation and evaluation of a water-in-oil nanoemulsion drug delivery
   system loaded with salidroside
SO CHINESE JOURNAL OF NATURAL MEDICINES
LA English
DT Article
DE Salidroside; Water-in-oil nanoemulsion; Polyphenol; Drug release;
   Pharmacokinetics; Bioavailability
AB Salidroside (SAL) is a phenolic substance with high solubility and low permeability, which make it easy to cause the efflux effect of P-glycoprotein and degradation of intestinal flora, resulting in lower bioavailability. The aim of this study was to develop and optimize a water-in-oil nanoemulsion of SAL (w/o SAL-N) to explore its suitability in oral drug delivery systems. In this work, SAL-N was successfully prepared by water titration method at K-m = 1 to construct the pseudo-ternary phase diagrams. Physical characterization including the average viscosity, pH, refractive index, particle size, PDI, TEM, DSC, the content of SAL, and stability study were performed. It was evaluated for drug release in vitro and pharmacokinetic studies in vivo. The optimized nanoemulsion formulation consisted of Labrafil M 1944CS (63%), Span-80/Tween-80/EtOH (27%) and 200 mg.mL(-1) SAL solution (SAL-SOL) (10%). Low viscosity and suitable pH were expected for the nanoemulsion. The spherical morphology and nanoscale size of SAL-N enhanced the stability of the nanoemulsion system. In vitro drug release showed that SAL-N had a better controlled release property than SAL-SOL at earlier time points. The pharmacokinetic studies exhibited that SAL-N had significantly higher in t(1/2) (2.11-fold), AUC(0-48) (h) (1.75fold) and MRT0-48 (h) (2.63-fold) than SAL-SOL (P < 0.01). The w/o SAL-N prepared in this work can be effectively delivered via the oral route. It can be seen w/o nanoemulsion is a strategy for the drug with polyphenols to delay the release, enhance oral absorption and reduce metabolic rate.
C1 [Liang Chun-Xia; Qi Dong-Li; Zhang Li-Na; Lu Peng; Liu Zhi-Dong] Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin 301617, Peoples R China.
   [Liang Chun-Xia; Qi Dong-Li; Zhang Li-Na; Lu Peng; Liu Zhi-Dong] Tianjin Univ Tradit Chinese Med, Engn Res Ctr Modern Chinese Med Discovery & Prepa, Minist Educ, Tianjin 301617, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine
RP Qi, DL; Liu, ZD (corresponding author), Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin 301617, Peoples R China.; Qi, DL; Liu, ZD (corresponding author), Tianjin Univ Tradit Chinese Med, Engn Res Ctr Modern Chinese Med Discovery & Prepa, Minist Educ, Tianjin 301617, Peoples R China.
EM qidongli@tjutcm.edu.cn; liuzhidong@tjutcm.edu.cn
RI Lu, Peng/GQB-1706-2022
OI Lu, Peng/0000-0002-7654-013X
FU Tianjin City High School Science Technology Fund Planning Project
   [2017KJ134]
FX This work was supported by Tianjin City High School Science Technology
   Fund Planning Project (No. 2017KJ134).
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NR 44
TC 25
Z9 29
U1 3
U2 74
PU CHINESE JOURNAL NATURAL MEDICINES
PI NANJING
PA 24, TONGJIA XIANG, NANJING, 210009, PEOPLES R CHINA
SN 2095-6975
EI 1875-5364
J9 CHIN J NAT MEDICINES
JI Chin. J. Nat. Med.
PD MAR
PY 2021
VL 19
IS 3
BP 231
EP 240
DI 10.1016/S1875-5364(21)60025-0
EA MAR 2021
PG 10
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA RF4WB
UT WOS:000634839500009
PM 33781457
DA 2026-05-27
ER

PT J
AU Yin, Y
   Liu, DJ
   Tian, DH
AF Yin, Yan
   Liu, Dejie
   Tian, Donghua
TI Salidroside prevents hydroperoxide-induced oxidative stress and
   apoptosis in retinal pigment epithelium cells
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE salidroside; age-related macular degeneration; oxidative stress;
   apoptosis
ID PEROXIDE-INDUCED INJURY; HUMAN RPE CELLS; MACULAR DEGENERATION;
   AKT/GSK-3-BETA PATHWAY; H9C2 CELLS; PROTECTS; ACTIVATION; PROMOTES; MICE
AB Salidroside (SAL) is the major pharmacologically active constituent of Rhodiola rosea, which possesses a wide range of pharmacological functions, including anti-aging, anti-inflammatory, antioxidant, anticancer and neuroprotective activities. However, the effects and mechanisms of SAL on oxidative stress in retinal pigment epithelial (RPE) cells exposed to hydrogen peroxide (H2O2) remain unclear. The present study investigated the protective effects of SAL and the underlying mechanisms against H2O2-induced oxidative stress in human RPE cells. ARPE-19 cells were treated with various doses of SAL for 24 h and then exposed to 200 mu M H2O2 for 24 h. Cell viability was analyzed by a MTT assay, and the intracellular levels of reactive oxygen species were measured using CellROX orange reagent. Cell apoptosis was analyzed by annexin V/propidium iodide double staining, followed by flow cytometry. The levels of B-cell lymphoma 2 (Bcl-2), Bcl-2-associated X protein, phospho (p)-protein kinase B (Akt), Akt, p-glycogen synthase kinase (GSK)-3 and GSK-3 were evaluated using western blotting. The results demonstrated that SAL markedly attenuated H2O2-induced loss of cell viability. SAL also ameliorated H2O2-induced oxidative stress and cell apoptosis in RPE cells. In addition, pretreatment with SAL significantly increased the phosphorylation levels of Akt and GSK-3 in H2O2-treated ARPE-19 cells. In conclusion, the present study demonstrated that SAL protected RPE cells against H2O2-induced cell injury through the activation of the Akt/GSK-3 signaling pathway. This suggests that SAL may be a potential therapeutic strategy for the treatment of age-related macular degeneration.
C1 [Yin, Yan; Tian, Donghua] Jining 1 Peoples Hosp, Dept Ophthalmol, 6 Hlth Rd, Jining 272011, Shandong, Peoples R China.
   [Liu, Dejie] Yantai Yeda Hosp, Dept Ophthalmol, Yantai 264006, Shandong, Peoples R China.
RP Tian, DH (corresponding author), Jining 1 Peoples Hosp, Dept Ophthalmol, 6 Hlth Rd, Jining 272011, Shandong, Peoples R China.
EM tiandong_hua@126.com
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NR 29
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U1 0
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PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD SEP
PY 2018
VL 16
IS 3
BP 2363
EP 2368
DI 10.3892/etm.2018.6494
PG 6
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA GS5UZ
UT WOS:000443738300111
PM 30210588
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xiang, Q
   Zhang, Y
   Chen, SQ
   Zhang, Y
   Fu, XX
   Tang, HY
   Tan, LM
   Zhang, YL
   Li, XH
   Gao, YG
   Zhang, YH
   Chen, L
   Zheng, T
   Wang, QB
AF Xiang, Qin
   Zhang, Yue
   Chen, Shiqi
   Zhang, Yu
   Fu, Xiangxiang
   Tang, Huaiying
   Tan, Liming
   Zhang, Yongli
   Li, Xiaohan
   Gao, Yanguo
   Zhang, Yonghong
   Chen, Li
   Zheng, Tao
   Wang, Qibin
TI Salidroside alleviates ethanol exposure-exacerbated hepatic insulin
   resistance in diabetic mice
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Ethanol; Diabetes; Salidroside; Insulin resistance; NLRP3
ID ALCOHOL-CONSUMPTION; RISK; INFLAMMATION; ACTIVATION; DISEASE; SYSTEM;
   MODEL
AB Long-term excessive ethanol consumption is known to accelerate the progression of diabetes mellitus (DM). Our previous study indicated that salidroside (SAL) improves hepatic insulin resistance in DM mice. However, the underlying mechanisms of ethanol on this process and whether SAL can exert a therapeutic effect are not fully understood. The aim of this study is to investigate the effect of SAL on ethanol-exacerbated hepatic insulin resistance and its underlying mechanisms in DM conditions. Primary mouse hepatocytes were isolated and cultured to establish an insulin sensitivity impaired model. The effects of ethanol exposure at different concentrations or for different durations on intracellular lipid accumulation, the insulin signaling pathway of Akt/ glycogen synthase kinase 3(3 (GSK3(3), and the NACHT, LRR and PYD domains-containing protein 3 (NLRP3) inflammasome signaling were observed. An NLRP3 inhibitor was used to determine whether the effects of ethanol were dependent on the overactivation of the NLRP3 inflammasome signaling and to investigate the intervention effects of SAL. A DM model was established by feeding a high-fat diet combined with streptozotocin injection to observe the effects of ethanol exposure on blood glucose and body weight, biochemical and histopathological indicators, as well as the Akt/GSK3(3 and NLRP3 inflammasome signaling in liver tissue. In vitro, ethanol exposure exacerbated lipid accumulation and insulin sensitivity impairment in hepatocytes in a concentration-and time-dependent manner. This effect was dependent on the overactivation of the NLRP3 inflammasome, and co-incubation with SAL could effectively improve the above phenomena. In vivo, ethanol exposure also exacerbated liver insulin resistance, and SAL treatment could improve this condition. SAL has an ameliorative effect on the ethanol-exacerbated liver insulin resistance in diabetic mice.
C1 [Xiang, Qin; Zhang, Yue; Chen, Shiqi; Zhang, Yu; Fu, Xiangxiang; Tang, Huaiying; Tan, Liming; Zhang, Yongli; Li, Xiaohan; Gao, Yanguo; Chen, Li; Zheng, Tao; Wang, Qibin] Hubei Univ Med, Sch Pharmaceut Sci, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan, Hubei, Peoples R China.
   [Xiang, Qin; Zhang, Yue; Chen, Shiqi; Zhang, Yu; Fu, Xiangxiang; Tang, Huaiying; Tan, Liming; Zhang, Yongli; Li, Xiaohan; Gao, Yanguo; Zhang, Yonghong; Chen, Li; Zheng, Tao; Wang, Qibin] Hubei Univ Med, Taihe Hosp, Inst Wudang Tradit Chinese Med, Dept Pharm, Shiyan, Hubei, Peoples R China.
   [Zhang, Yu; Chen, Li; Zheng, Tao; Wang, Qibin] Hubei Univ Med, Taihe Hosp, Hubei Clin Res Ctr Precise Diag & Treatment Liver, Shiyan, Hubei, Peoples R China.
C3 Hubei University of Medicine; Hubei University of Medicine; Hubei
   University of Medicine
RP Zheng, T; Wang, QB (corresponding author), 32 Renmin Rd, Shiyan 442000, Hubei, Peoples R China.
EM ztice@foxmail.com; taihe321@163.com
FU National Natural Science Foundation of China [81703582]; Hubei
   Provincial Natural Science Foundation of China [2016CFB153, 2020CFB713];
   Health Commission of Hubei Province Scientific Research Project
   [WJ2019M057, WJ2021ZH0017]; Advantages Discipline Group (Biology and
   Medicine) Project in Higher Education of Hubei Province (2021-2025)
   [2022BMXKQT3, 2023BMXKQT3, 2024BMXKQT3, 2025BMXKQT3]; Innovative
   Research Program for Graduates of Hubei University of Medicine
   [YC2025024, YC2025033, YC2025037]; Wu Jieping Medical Foundation
   [320.6750.2023-25-7]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81703582) , the Hubei Provincial Natural Science
   Foundation of China (2016CFB153 and 2020CFB713) , the Health Commission
   of Hubei Province Scientific Research Project (WJ2019M057 and
   WJ2021ZH0017) , the Advantages Discipline Group (Biology and Medicine)
   Project in Higher Education of Hubei Province (2021-2025) (2022BMXKQT3,
   2023BMXKQT3, 2024BMXKQT3, and 2025BMXKQT3) , the Innovative Research
   Program for Graduates of Hubei University of Medicine (YC2025024,
   YC2025033, and YC2025037) , and the Wu Jieping Medical Foundation
   (320.6750.2023-25-7) .
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NR 53
TC 1
Z9 1
U1 1
U2 1
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD FEB 15
PY 2026
VL 171
AR 116101
DI 10.1016/j.intimp.2025.116101
EA DEC 2025
PG 12
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA AW4NY
UT WOS:001658389900001
PM 41477995
DA 2026-05-27
ER

PT J
AU Wen, ZX
   Liu, T
   Zhang, YL
   Yue, QJ
   Meng, H
   He, YJ
   Yang, Y
   Li, MH
   Zheng, JW
   Lin, W
AF Wen, Zexin
   Liu, Tong
   Zhang, Yanli
   Yue, Qiujuan
   Meng, Hang
   He, Yijie
   Yang, Yi
   Li, Minghao
   Zheng, Jianwen
   Lin, Wei
TI Salidroside regulates tumor microenvironment of non-small cell lung
   cancer via Hsp70/Stub1/Foxp3 pathway in Tregs
SO BMC CANCER
LA English
DT Article
DE Salidroside; Non-small cell lung cancer; Tumor microenvironment; Treg;
   Stub1
ID DENDRITIC CELLS; IMMUNOSUPPRESSIVE NETWORKS; PROLIFERATION; MIGRATION;
   RHODIOLA; SIGNALS; GROWTH; TISSUE
AB BackgroundThe treatment of non-small cell lung cancer (NSCLC) is challenging due to immune tolerance and evasion. Salidroside (SAL) is an extract in traditional Chinese medicine and has a potential antitumor effect. However, the mechanism of SAL in regulating the immunological microenvironment of NSCLC is yet to be clarified.MethodsThe mouse model with Lewis lung cancer cell line (3LL) in C57BL/6 mice was established. And then, the percentage of tumor-infiltrating T cell subsets including Treg was detected in tumor-bearing mice with or without SAL treatment. In vitro, the effect of SAL on the expression of IL-10, Foxp3 and Stub1 and the function of Treg were detected by flow cytometry. Network pharmacology prediction and molecular docking software were used to predict the target of SAL and intermolecular interaction. Furthermore, the effect of SAL on the expression of Hsp70 and the co-localization of Stub1-Foxp3 in Treg was confirmed by flow cytometry and confocal laser microscopy. Finally, Hsp70 inhibitor was used to verify the above molecular expression.ResultsWe discovered that SAL treatment inhibits the growth of tumor cells by decreasing the percentage of tumor-infiltrated CD4(+)Foxp3(+)T cells. SAL treatment downregulates the expression of Foxp3 in Tregs, but increases the expression of Stub1, an E3 ubiquitination ligase upstream of Foxp3, and the expression of Hsp70. Inhibiting the expression of Hsp70 reverses the inhibition of SAL on Foxp3 and disrupts the colocalization of Stub1 and Foxp3 in the nucleus of Tregs.ConclusionsSAL inhibits tumor growth by regulating the Hsp70/stub1/Foxp3 pathway in Treg to suppress the function of Treg. It is a new mechanism of SAL for antitumor therapy.
C1 [Wen, Zexin; Liu, Tong; Zhang, Yanli; Yue, Qiujuan; Meng, Hang; He, Yijie; Yang, Yi; Zheng, Jianwen] Xizang Minzu Univ, Dept Med, Xianyang, Shaanxi, Peoples R China.
   [Liu, Tong] Xinjiang Med Univ, Basic Med Coll, Urumqi, Peoples R China.
   [Li, Minghao; Lin, Wei] Shandong First Med Univ, Affiliated Hosp 1, Shandong Prov Qianfoshan Hosp, Dept Oncol, Jinan, Peoples R China.
   [Li, Minghao; Lin, Wei] Shandong First Med Univ, Sch Clin & Basic Med, Jinan, Peoples R China.
   [Li, Minghao; Lin, Wei] Shandong Acad Med Sci, Jinan, Peoples R China.
   [Li, Minghao; Lin, Wei] Shandong First Med Univ, Affiliated Hosp 1, Shandong Lung Canc Inst, Shandong Key Lab Rheumat Dis & Translat Med, Jinan, Peoples R China.
   [Lin, Wei] Shandong First Med Univ, Shandong Prov Hosp, Dept Crit care Med, Jinan, Peoples R China.
C3 Xizang Minzu University; Xinjiang Medical University; Shandong First
   Medical University & Shandong Academy of Medical Sciences; Shandong
   First Medical University & Shandong Academy of Medical Sciences;
   University of Jinan; Shandong First Medical University & Shandong
   Academy of Medical Sciences; Shandong First Medical University &
   Shandong Academy of Medical Sciences; Shandong First Medical University
   & Shandong Academy of Medical Sciences
RP Zheng, JW (corresponding author), Xizang Minzu Univ, Dept Med, Xianyang, Shaanxi, Peoples R China.; Lin, W (corresponding author), Shandong First Med Univ, Affiliated Hosp 1, Shandong Prov Qianfoshan Hosp, Dept Oncol, Jinan, Peoples R China.; Lin, W (corresponding author), Shandong First Med Univ, Sch Clin & Basic Med, Jinan, Peoples R China.; Lin, W (corresponding author), Shandong Acad Med Sci, Jinan, Peoples R China.; Lin, W (corresponding author), Shandong First Med Univ, Affiliated Hosp 1, Shandong Lung Canc Inst, Shandong Key Lab Rheumat Dis & Translat Med, Jinan, Peoples R China.; Lin, W (corresponding author), Shandong First Med Univ, Shandong Prov Hosp, Dept Crit care Med, Jinan, Peoples R China.
EM 1024559902@qq.com; linw1978@163.com
RI Liu, Tong/I-5798-2018; Li, Minghao/P-3228-2016
FU National Natural Science Foundation of China [81860719]
FX <STRONG>& nbsp;T</STRONG>his study was supported by the National Natural
   Science Foundation of China (81860719).
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Z9 32
U1 3
U2 24
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1471-2407
J9 BMC CANCER
JI BMC Cancer
PD AUG 1
PY 2023
VL 23
IS 1
AR 717
DI 10.1186/s12885-023-11036-5
PG 11
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA O0SD9
UT WOS:001040998000003
PM 37528345
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yan, TX
   Nian, TT
   Li, FY
   He, BS
   Jia, Y
   Bi, KS
   Wang, ZZ
AF Yan, Tingxu
   Nian, Tingting
   Li, Fuyuan
   He, Bosai
   Jia, Ying
   Bi, Kaishun
   Wang, Zhenzhong
TI RETRACTED: Salidroside fromRhodiola
   wallichianavar.cholaensisreverses insulin resistance and
   stimulates the GLP-1 secretion by alleviating ROS-mediated activation of
   MAPKs signaling pathway and mitigating apoptosis (Retracted Article)
SO JOURNAL OF FOOD BIOCHEMISTRY
LA English
DT Article; Retracted Publication
DE GLP-1; insulin resistance; MAPK; oxidative stress; salidroside
ID CHAIN FATTY-ACIDS; OXIDATIVE STRESS; BAX TRANSLOCATION; L-CELL;
   LIRAGLUTIDE; INHIBITION; MECHANISMS; OBESITY; P38
AB The present study was aimed to investigate the mechanisms of salidroside (SAL) fromRhodiola wallichianavar.cholaensison hypoglycemic and oxidative stress responses. The palmitate (PA)-induced GLUTag cells model and the glucosamine-induced insulin resistance model in HepG2 cells were built. SAL led to the up-regulation of the serum glucagon-like peptide 1 (GLP-1) level by facilitating the SCFAs production, the promotion of GLP-1 synthesis by improving p38 MAPK phosphorylation and regulating insulin resistance. Moreover, the production of reactive oxygen species (ROS) and the expression of MAPKs were down-regulated. Furthermore, SAL was found to be able to inhibit PA-induced apoptosis that down-regulates cleaved caspase-3 and Bax expressions, while up-regulating Bcl-2 expression and up-regulates the Bcl-2/Bax ratio in glucosamine induced insulin resistance model. Besides, SAL can also up-regulate the mTOR/p70S6k signaling pathway in the PA-induced GLUTag cells model. Our data demonstrated that SAL could reverse insulin resistance and stimulates the GLP-1 secretion by alleviating ROS-mediated activation of MAPKs signaling pathway and mitigating apoptosis. Practical applications Our data showed that SAL could increase the GLP-1 level by stimulating the SCFAs production and p38 phosphorylation and facilitate the IR and GLP-1 synthesis by alleviating ROS-mediated activation of MAPKs signaling pathway and mitigating apoptosis. Furthermore, the SAL has also stimulated the mTOR/p70S6k signaling pathway in PA-induced GLUTag cells model. The results provided a possibility to employ SAL for diabetes treatment.
C1 [Yan, Tingxu; Wang, Zhenzhong] Jiangsu Kangyuan Pharmaceut Co Ltd, Lianyungang 222047, Peoples R China.
   [Yan, Tingxu; He, Bosai; Jia, Ying] Shenyang Pharmaceut Univ, Sch Funct Food & Wine, Shenyang, Peoples R China.
   [Nian, Tingting; Li, Fuyuan] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Med, Shenyang, Peoples R China.
   [Bi, Kaishun] Shenyang Pharmaceut Univ, Sch Pharm, Wenhua Rd 103, Shenyang 110016, Peoples R China.
   [Wang, Zhenzhong] Jiangsu Kan Pharmaceut Co Ltd, State Key Lab New Tech Chinese Med Pharmaceut Pro, Lianyungang, Peoples R China.
C3 Shenyang Pharmaceutical University; Shenyang Pharmaceutical University;
   Shenyang Pharmaceutical University
RP Wang, ZZ (corresponding author), Jiangsu Kangyuan Pharmaceut Co Ltd, Lianyungang 222047, Peoples R China.; Bi, KS (corresponding author), Shenyang Pharmaceut Univ, Sch Pharm, Wenhua Rd 103, Shenyang 110016, Peoples R China.
EM bikaishun@126.com; wzhzh-nj@163.com
RI He, Bosai/OML-7628-2025
OI He, Bosai/0000-0003-0956-9546
FU Precise screening technology of Chinese traditional medicine
   anti-depressant active ingredients [2017LZD01]; Doctoral Scientific
   Research Foundation of Liaoning Province [2019-BS-233]
FX Key laboratory of polysaccharide bioactivity evaluation of TCM of
   Liaoning Province. Liaoning Distinguished Professor Project for Ying Jia
   (2017). Precise screening technology of Chinese traditional medicine
   anti-depressant active ingredients (2017LZD01). The Doctoral Scientific
   Research Foundation of Liaoning Province(2019-BS-233). GLUTag
   transfected cells were provided by Daniel J. Drucker M.D. (Mt. Sinai
   Hospital, Toronto, Ontario, Canada).
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TC 5
Z9 6
U1 1
U2 52
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0145-8884
EI 1745-4514
J9 J FOOD BIOCHEM
JI J. Food Biochem.
PD NOV
PY 2020
VL 44
IS 11
AR e13446
DI 10.1111/jfbc.13446
EA SEP 2020
PG 13
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA OY0PV
UT WOS:000567695800001
PM 32910486
DA 2026-05-27
ER

PT J
AU Li, DH
   Lv, YS
   Liu, JH
   Yang, L
   Wang, Y
   Zhang, SK
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AF Li, Di-Hua
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TI Simultaneous Determination of Four Active Ingredients in
   Sargentodoxa cuneata by HPLC Coupled with Evaporative
   Light Scattering Detection
SO INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY
LA English
DT Article
ID CHLOROGENIC ACID; IN-VITRO; HYDROXYTYROSOL; INHIBITION; CONSTITUENTS;
   SALIDROSIDE; TRITERPENE; ROOTS; STEM
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C3 Tianjin University of Traditional Chinese Medicine
RP Li, DH (corresponding author), Tianjin Inst Acute Abdominal Dis Integrated Tradi, Tianjin 300100, Peoples R China.
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NR 32
TC 10
Z9 12
U1 0
U2 13
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1687-8760
EI 1687-8779
J9 INT J ANAL CHEM
JI Int. J. Anal. Chem.
PY 2016
VL 2016
AR 8509858
DI 10.1155/2016/8509858
PG 7
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA DO6SR
UT WOS:000377914200001
PM 27313618
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Beretta, GL
AF Beretta, Giovanni Luca
TI Ferroptosis-induced Cardiotoxicity and Antitumor Drugs
SO CURRENT MEDICINAL CHEMISTRY
LA English
DT Review
DE Ferroptosis; iron; cardiotoxicity; cardiomyocytes; cardioprotective
   agents; reactive oxygen species
ID DOXORUBICIN-INDUCED CARDIOTOXICITY; CELL-DEATH; OXIDATIVE STRESS;
   DYSFUNCTION; IRON; CARDIOMYOCYTES; PEROXIDATION; SALIDROSIDE;
   METABOLISM; MECHANISMS
AB The induction of regulated cell death ferroptosis in tumors is emerging as an intriguing strategy for cancer treatment. Numerous antitumor drugs (e.g., doxorubicin, etoposide, tyrosine kinase inhibitors, trastuzumab, arsenic trioxide, 5-fluorouracil) induce ferroptosis. Although this mechanism of action is interesting for fighting tumors, the clinical use of drugs that induce ferroptosis is hampered by cardiotoxicity. Besides in cancer cells, ferroptosis induced by chemotherapeutics can occur in cardiomyocytes, and this feature represents an important drawback of antitumor therapy. This inconvenience has been tackled by developing less or no cardiotoxic antitumor drugs or by discovering cardioprotective agents (e.g., berberine, propofol, fisetin, salidroside, melatonin, epigallocatechin-3gallate, resveratrol) to use in combination with conventional chemotherapeutics. This review briefly summarizes the molecular mechanisms of ferroptosis and describes the ferroptosis dependent mechanisms responsible for cardiac toxicity developed by cancer-suffering patients following the administration of some chemotherapeutics. Additionally, the pharmacological strategies very recently proposed for potentially preventing this inconvenience are considered.
C1 [Beretta, Giovanni Luca] Fdn IRCCS Ist Nazl Tumori, Dept Expt Oncol, Mol Pharmacol Unit, I-20133 Milan, Italy.
C3 Fondazione IRCCS Istituto Nazionale Tumori Milan
RP Beretta, GL (corresponding author), Fdn IRCCS Ist Nazl Tumori, Dept Expt Oncol, Mol Pharmacol Unit, I-20133 Milan, Italy.
EM iovanni.beretta@istitutotumori.mi.it
RI Beretta, Giovanni/J-6041-2016
OI Beretta, Giovanni/0000-0002-5961-4109
FX Declared none.
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NR 125
TC 13
Z9 14
U1 2
U2 23
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 0929-8673
EI 1875-533X
J9 CURR MED CHEM
JI Curr. Med. Chem.
PY 2024
VL 31
IS 31
BP 4935
EP 4957
DI 10.2174/0929867331666230719124453
PG 23
WC Biochemistry & Molecular Biology; Chemistry, Medicinal; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy
GA A6B3K
UT WOS:001283362400003
PM 37469161
DA 2026-05-27
ER

PT J
AU Huang, QL
   Wang, ZT
   Xu, YQ
   Gao, L
   Hu, LF
   Ji, SY
   Lu, BY
AF Huang, Qinle
   Wang, Zhangtie
   Xu, Yongquan
   Gao, Liang
   Hu, Linfu
   Ji, Shengyang
   Lu, Baiyi
TI Multiscale Elucidation of Taste Interactions in Osmanthus Green Tea:
   Bitter Masking via EGCG and Phenylethanoid Glycoside Interplay
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE summer-autumngreen tea; <italic>Osmanthus fragrans</italic>; EGCG;
   catechins; phenylethanoid glycosides; bitterness masking; molecular
   dynamics
ID AROMA COMPOUNDS
AB This study revealed the molecular mechanism by which Osmanthus fragrans masks the bitterness of summer-autumn green tea infusion. Taste dilution analysis identified catechins such as EGCG in green tea as the primary bitter compounds. Phenylethanoid glycosides (PhGs), such as verbascoside and salidroside in Osmanthus fragrans exhibited significant bitter-masking effects. Molecular docking identified TAS2R31 as the primary bitter receptor for EGCG, with verbascoside or salidroside competitively disrupting the EGCG-TAS2R31 binding. Molecular dynamics simulations showed that PhGs altered the TAS2R31 conformation, reducing its alpha-helix content, increasing structural flexibility, and decreasing hydrogen bonding with EGCG. This conformational change correlated with a decrease in the binding affinity of TAS2R31 for EGCG. Spectroscopic analysis further demonstrated that PhGs efficiently quenched the intrinsic fluorescence of TAS2R31. Thus, the Osmanthus-derived PhGs were a key substance that reduces the bitterness of OSGT, which could affect the binding between EGCG and bitterness receptors by altering the conformation of bitterness receptors.
C1 [Huang, Qinle; Wang, Zhangtie; Ji, Shengyang; Lu, Baiyi] Zhejiang Univ, Coll Biosyst Engn & Food Sci, Hangzhou 310058, Peoples R China.
   [Xu, Yongquan] Chinese Acad Agr Sci, Key Lab Tea Biol & Resources Utilizat, Minist Agr & Rural Affairs, Tea Res Inst, Hangzhou 310008, Peoples R China.
   [Gao, Liang; Hu, Linfu] Zhejiang Shengshi Biotechnol Co Ltd, Hu Zhou 313000, Peoples R China.
C3 Zhejiang University; Chinese Academy of Agricultural Sciences; Tea
   Research Institute, CAAS
RP Ji, SY; Lu, BY (corresponding author), Zhejiang Univ, Coll Biosyst Engn & Food Sci, Hangzhou 310058, Peoples R China.
EM Shengyang_ji@163.com; bylu@zju.edu.cn
RI Yang, Bowen/KWV-0501-2024
FU Earmarked fund for Key Technologies Research and Development Program of
   China [2024YFD2100103]; San Nong Jiu Fang Science and Technology
   Cooperation Project of Zhejiang [2024SNJF028]
FX The authors gratefully acknowledge the financial support from the
   earmarked fund for Key Technologies Research and Development Program of
   China (2024YFD2100103 ) and the "San Nong Jiu Fang" Science and
   Technology Cooperation Project of Zhejiang (2024SNJF028).
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NR 71
TC 2
Z9 2
U1 46
U2 58
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD NOV 5
PY 2025
VL 73
IS 44
BP 28345
EP 28358
DI 10.1021/acs.jafc.5c11186
EA OCT 2025
PG 14
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA 9KH6F
UT WOS:001598322000001
PM 41123028
DA 2026-05-27
ER

PT J
AU Ming, X
   Yu, XZ
   Li, JJ
   Wang, JY
   Zheng, JL
   Xiong, L
AF Ming, Xi
   Yu, Xingzhu
   Li, Jijun
   Wang, Junyu
   Zheng, Jialin
   Xiong, Lei
TI Salidroside Attenuates Airway Inflammation and Remodeling via the
   miR-323-3p/SOCS5 Axis in Asthmatic Mice
SO INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
LA English
DT Article
DE Asthma; Salidroside; Airway inflammation; Airway remodeling; miR-323-3p;
   SOCS5
ID MICRORNA-323-3P
AB Introduction: Salidroside (Sal) a bioactive component extracted from Rhodiola rosea is remarkable for its anti-asthmatic effects. The study aimed to explore the molecular mechanism of Sal in airway inflammation and remodeling in asthmatic mice and provide a novel theoretical basis for asthma treatment. Methods: An asthmatic mouse model was established via ovalbumin (OVA) treatment, followed by injection of Sal and transfection of miR-323-3p-mimic and sh- suppressor of cytokine signaling 5 (SOCS5). Expressions of miR-323-3p, SOCS5 mRNA, collagen (COL)-I, and COL-III were detected via reverse transcription quantitative polymerase chain reaction. SOCS5 protein level was detected via Western blot. Levels of IgE, IL-13, IL-4, and IL-5 were detected via enzyme-linked immunosorbent assay. Inflammatory cell infiltration was observed via hematoxylin-eosin staining. Collagen disposition was observed via Masson staining. Resistance index (RI) of airway hyperresponsiveness, and the number of total cells, inflammatory cells (eosinophil, macrophage, neutrophil, and lymphocyte) in bronchoalveolar lavage fluid (BALF) were observed. The binding relationship between miR-323-3p and SOCS5 was predicted through the RNA22 website and verified via dual-luciferase reporter assay. Results: miR-323-3p was highly expressed in OVA-treated mice. Sal treatment reduced inflammatory cell infiltration, COL disposition, miR-323-3p expression, and IgE, IL-13, IL-4, IL-5, COL-I, and COL-III levels, RI value, and the number of total cells and inflammatory cells in BALF. miR-323-3p inhibited SOCS5 transcription. miR-323-3p overexpression or SOCS5 downregulation reversed the protecting role of Sal in asthmatic mice. Conclusion: Sal inhibited miR-323-3p expression to promote SOCS5 transcription, thereby attenuating airway inflammation and remodeling in asthmatic mice.
C1 [Ming, Xi] Yunnan Univ Chinese Med, Hosp Affiliated 1, Dept Pediat, Dept Integrat Med Pediat, Kunming, Yunnan, Peoples R China.
   [Ming, Xi; Yu, Xingzhu; Xiong, Lei] Yunnan Univ Chinese Med, Clin Med Coll 1, Kunming, Yunnan, Peoples R China.
   [Li, Jijun] Shanghai Jiao Tong Univ, Shanghai Childrens Ctr, Dept Integrat Med Pediat, Sch Med, Shanghai, Peoples R China.
   [Wang, Junyu] Kunming Med Univ, Dept Anesthesiol, Yanan Hosp, Kunming, Yunnan, Peoples R China.
   [Zheng, Jialin] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan, Peoples R China.
C3 Yunnan University of Chinese Medicine; Yunnan University of Chinese
   Medicine; Shanghai Jiao Tong University; Kunming Medical University;
   Shandong University of Traditional Chinese Medicine
RP Ming, X (corresponding author), Yunnan Univ Chinese Med, Hosp Affiliated 1, Dept Pediat, Dept Integrat Med Pediat, Kunming, Yunnan, Peoples R China.; Ming, X; Xiong, L (corresponding author), Yunnan Univ Chinese Med, Clin Med Coll 1, Kunming, Yunnan, Peoples R China.
EM ximing03106@163.com; wjg0jdq6jtn0ajgq@163.com
OI Xiong, Lei/0000-0003-3799-7679
FU National Natural Science Founda-tion of China
FX This work was supported by National Natural Science Founda-tion of China
   (No. 82060884).
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NR 38
TC 12
Z9 14
U1 1
U2 8
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-2438
EI 1423-0097
J9 INT ARCH ALLERGY IMM
JI Int. Arch. Allergy Immunol.
PD APR
PY 2022
VL 183
IS 4
BP 424
EP 434
DI 10.1159/000520444
EA DEC 2021
PG 11
WC Allergy; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Immunology
GA G5IO7
UT WOS:000729133300001
PM 34856542
DA 2026-05-27
ER

PT J
AU Li, T
   Feng, Y
   Yang, RX
   Wu, LT
   Li, RR
   Huang, L
   Yang, Q
   Chen, JZ
AF Li, Tao
   Feng, Yang
   Yang, Ruixin
   Wu, Leitao
   Li, Ruru
   Huang, Lu
   Yang, Qian
   Chen, Jianzong
TI Salidroside Promotes the Pathological α-Synuclein Clearance Through
   Ubiquitin-Proteasome System in SH-SY5Y Cells
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE Parkinson's disease; salidroside; alpha-synuclein; UPS; 6-OHDA
ID PARKINSONS-DISEASE; NEURODEGENERATIVE DISORDERS; PROTEIN-DEGRADATION;
   TRANSGENIC MICE; INDUCED MODEL; IN-VIVO; AUTOPHAGY; PHOSPHORYLATION;
   PATHWAY; GENE
AB Parkinson's disease (PD) is characterized by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNc) and the presence of Lewy bodies (LBs) in the surviving SNc neurons. LBs formation is caused by the accumulation of alpha-synuclein (alpha-syn) or phosphorylated alpha-syn at serine-129 (pSer129-alpha-syn), which is implicated in the pathological progression of PD. Salidroside (Sal), the main active ingredient of the root of Rhodiola rosea L., has been reported to have potent neuroprotective properties in our previous investigations. Here, we investigated the effects of Sal on 6-OHDA and overexpresssion of WT/A30P-alpha-syn-induced pathological alpha-syn increase and the mechanism behind it in SH-SY5Y cells. We found Sal displays neuroprotective effects against 6-hydroxydopamine (6-OHDA)-induced cytotoxicity. Sal decreased the pSer129-alpha-syn level mainly by maintaining the normal function of ubiquitin-proteasome system (UPS). Furthermore, Sal promoted the clearance of alpha-syn and protected the cell viability mainly through recovered the 20S proteasome activity in WT/A30P-alpha-syn-transfected cells. These data provide new mechanistic insights into the neuroprotective effects of Sal and Sal may be a promising therapy to slow neurodegeneration in PD.
   Highlights: Sal protects cells and decreases the pSer129-alpha-syn protein level in 6-OHDA-induced impairmental and dysfunctional SH-SY5Y cells.
   Sal promotes the clearance of alpha-syn and protects the cell viability mainly through recovering the 20S proteasome activity in WT/A30P-alpha-syn plasmids transfected cells.
   Maintaining the normal function of the UPS may be one of the important mechanisms of Sal in neuroprotective effects.
C1 [Li, Tao; Feng, Yang; Wu, Leitao; Li, Ruru; Chen, Jianzong] Fourth Mil Med Univ, Xijing Hosp, Res Ctr Tradit Chinese Med, Xian, Shaanxi, Peoples R China.
   [Yang, Ruixin; Huang, Lu; Yang, Qian] Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian, Shaanxi, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Chen, JZ (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Res Ctr Tradit Chinese Med, Xian, Shaanxi, Peoples R China.; Yang, Q (corresponding author), Fourth Mil Med Univ, Tangdu Hosp, Dept Neurosurg, Xian, Shaanxi, Peoples R China.
EM qianyang@fmmu.edu.cn; jzchen57@fmmu.edu.cn
RI yang, qian/HTS-5357-2023; Li, Tao/LJM-1988-2024
OI Li, Tao/0000-0003-4512-2215
FU National Natural Science Foundation of China [81173590]
FX This work was supported by the National Natural Science Foundation of
   China (Grant No. 81173590).
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NR 52
TC 33
Z9 37
U1 2
U2 17
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD APR 19
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VL 9
AR 377
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PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GD3KC
UT WOS:000430401800003
PM 29725300
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xiao, LL
   Li, L
   Huang, JC
   Luan, YT
   Pan, JY
   Gai, Y
   Xu, ZY
AF Xiao, Lingling
   Li, Liang
   Huang, Jingcong
   Luan, Yuting
   Pan, Jiaying
   Gai, Yun
   Xu, Zhenyu
TI Salidroside attenuates lipopolysaccharide-induced neuroinflammation and
   cognitive impairment in septic encephalopathy mice
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Salidroside; Lipopolysaccharide; Autophagy; Neuroinflammation; Cognitive
   impairment
ID ACUTE LUNG INJURY; ALZHEIMERS-DISEASE; MICROGLIA; SIRT1; HIPPOCAMPUS;
   INHIBITION; ACTIVATION; PROTECTS; MODEL
AB Salidroside (SAL) is a natural bioactive compound with anti-oxidative, anti-inflammatory, and neuroprotective properties. In the present study, we generate an experimental design to investigate SAL-mediated protective effect and underlying mechanism on lipopolysaccharide (LPS)-induced neuroinflammation and cognitive impairment in the septic encephalopathy mice model (SEMM). In SEMM, Open-Field Test (OFT) and Novel Object Recognition Test evaluated LPS-induced cognitive impairment, behavioural phenotypes, and memory impairment (NOR). Cytokines and protein expression were assessed using ELISA assay, RT-qPCR, and Western blotting. Our results showed cognitive dysfunction could be reversed when treated with SAL in SEMM. SAL treatment significantly reduced apoptotic TUNEL-positive cells and related gene expression (BAX and BCL-2) and considerably improved neuronal damage in SEMM. In addition, it markedly reduced the production of inflam-matory cytokines (TNF-alpha, IL-1 beta, and IL-6) and Iba-1-positive cells responsible for microglial activation in mice hippocampus (P < 0.05). The effects of SAL on ROS and oxidative stress markedly reduced malondialdehyde (MDA) content and increased superoxide dismutase (SOD) and catalase (CAT) in the hippocampal tissues of mice. Besides, SAL treatment enhanced LPS-induced autophagy in mice's hippocampus and increased autophagy-related protein expression (Beclin-1 and P62). In addition, the NLRP3 inflammasome pathway and its related proteins (NLRP3, ASC, and cleaved caspase-1) were suppressed by SAL treatment. However, SAL activated the SIRT1/Nrf2 pathway and exerts protection by enhanced expression of the proteins (SIRT1 and Nrf2) and downstream genes (HO-1 and NQO1). Our finding demonstrated that SAL employed neuroprotective effects in SEMM by promoting autophagy via activation of the SIRT1 pathway.
C1 [Xiao, Lingling; Li, Liang; Huang, Jingcong; Luan, Yuting; Pan, Jiaying; Gai, Yun; Xu, Zhenyu] Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Dept Emergency Med, 358 Datong Rd,Pudong New Area, Shanghai 200137, Peoples R China.
   [Gai, Yun] Shanghai Univ Tradit Chinese Med, Gen Practice Med, Peoples Hosp 7, 358 Datong Rd,Pudong New Area, Shanghai 200137, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Gai, Y; Xu, ZY (corresponding author), Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Dept Emergency Med, 358 Datong Rd,Pudong New Area, Shanghai 200137, Peoples R China.
EM gaiyunlucky@163.com; Xzy2062@163.com
FU Shanghai Pudong New Area Science and Technology Development Fund
   People's livelihood scientific research special fund medical and health
   project [PKJ2021-Y02]; Shanghai Pudong New Area Health System Key
   Specialty Construction Project [PWZzk2022-15]; "Big Dipper" talent
   training project of Shanghai Seventh People's Hospital [BDX2021-03]
FX This study was supported by (1) Shanghai Pudong New Area Science and
   Technology Development Fund People's livelihood scientific research
   special fund medical and health project (PKJ2021-Y02) . (2) Shanghai
   Pudong New Area Health System Key Specialty Construction Project
   (PWZzk2022-15) . (3) "Big Dipper" talent training project of Shanghai
   Seventh People's Hospital (BDX2021-03) .
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NR 33
TC 13
Z9 14
U1 1
U2 16
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD APR
PY 2023
VL 117
AR 109975
DI 10.1016/j.intimp.2023.109975
EA MAR 2023
PG 9
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA C1SI2
UT WOS:000959795300001
PM 36948107
OA hybrid
DA 2026-05-27
ER

PT J
AU Seczyk, LS
   Sugier, D
   Dervisoglu, G
   Özdemir, FA
   Kolodziej, B
AF Seczyk, Lukasz S.
   Sugier, Danuta
   Dervisoglu, Gokhan
   Ozdemir, Fethi Ahmet
   Kolodziej, Barbara
TI Phytochemical profile, in vitro bioaccessibility, and anticancer
   potential of golden root (Rhodiola rosea L.) extracts br
SO FOOD CHEMISTRY
LA English
DT Article
DE Cytotoxic activity; Food supplement; Herbal preparations; In vitro
   digestion; Rosavins; Roseroot
ID ACTIVE COMPOUNDS; SALIDROSIDE; PROLIFERATION; L.; INDUCTION; APOPTOSIS;
   DIGESTION; ROSEROOT; GROWTH
AB The effects of water and ethanolic (40 %, 70 %, and 96 %) extraction on the Rhodiola rosea L. phytochemical profile (HPLC analysis), stability during extract drying, potential bioaccessibility in simulated gastric and intestinal conditions, and cytotoxic activity against human colorectal adenocarcinoma cells (Caco-2 and HT-29 cell lines) were investigated. The phytochemical profile, extractability, and stability during extract processing depend on the solvent type. In general, compounds derived from dry extracts were characterized by higher bioaccessibility than those extracted from powdered plant material. In the case of salidroside, tyrosol, and rosavins, one of the highest bioaccessibilities (often about 100 %) were found for the 70 % ethanolic extract after gastric digestion. Furthermore, the 70 % ethanolic extract most effectively reduced the viability of Caco-2 cells (IC50 85.8 mu g center dot mL-1). The results suggest that golden root extracts, in particular 70 % ethanolic extract, seem to be promising supplements for the food industry.
C1 [Seczyk, Lukasz S.; Sugier, Danuta; Kolodziej, Barbara] Univ Life Sci Lublin, Dept Ind & Med Plants, 15 Akad Str, PL-20950 Lublin, Poland.
   [Dervisoglu, Gokhan; Ozdemir, Fethi Ahmet] Bingol Univ, Fac Sci & Art, Dept Mol Biol & Genet, TR-1200 Bingol, Turkiye.
C3 University of Life Sciences in Lublin; Bingol University
RP Seczyk, LS (corresponding author), Univ Life Sci Lublin, Dept Ind & Med Plants, 15 Akad Str, PL-20950 Lublin, Poland.
EM lukasz.seczyk@up.lublin.pl; danuta.sugier@up.lublin.pl;
   gdervisoglu@bingol.edu.tr; faozdemir@bingol.edu.tr;
   barbara.kolodziej@up.lublin.pl
RI Sęczyk, Łukasz/U-3358-2018; DERVİŞOĞLU, Gökhan/AAW-7494-2021
OI Sęczyk, Łukasz/0000-0002-3795-0566; DERVİŞOĞLU,
   Gökhan/0000-0001-7195-2031
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NR 35
TC 19
Z9 21
U1 5
U2 82
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD MAR 15
PY 2023
VL 404
AR 134779
DI 10.1016/j.foodchem.2022.134779
EA NOV 2022
PN B
PG 10
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA 6A7LS
UT WOS:000880833100003
PM 36332586
DA 2026-05-27
ER

PT J
AU Li, JF
   Zhang, ZY
   Zhu, CH
   Zheng, XR
   Wang, CL
   Jiang, JW
   Zhang, HY
AF Li, Junfei
   Zhang, Zengyu
   Zhu, Chenghui
   Zheng, Xiaorong
   Wang, Chunlei
   Jiang, Jianwei
   Zhang, Hongyan
TI Salidroside enhances NO bioavailability and modulates arginine
   metabolism to alleviate pulmonary arterial hypertension
SO EUROPEAN JOURNAL OF MEDICAL RESEARCH
LA English
DT Article
DE Salidroside; Pulmonary artery hypertension; Arginine metabolism; NO
   bioavailability
AB BackgroundSalidroside (SAL), derived from Rhodiola, shows protective effects in pulmonary arterial hypertension (PAH) models, but its mechanisms are not fully elucidated.ObjectivesInvestigate the therapeutic effects and the mechanism of SAL on PAH.MethodsMonocrotaline was used to establish a PAH rat model. SAL's impact on oxidative stress and inflammatory responses in lung tissues was analyzed using immunohistochemistry, ELISA, and Western blot. Untargeted metabolomics explored SAL's metabolic regulatory mechanisms.ResultsSAL significantly reduced mean pulmonary artery pressure, right ventricular hypertrophy, collagen deposition, and fibrosis in the PAH rats. It enhanced antioxidant enzyme levels, reduced inflammatory cytokines, and improved NO bioavailability by upregulating endothelial nitric oxide synthase (eNOS), soluble guanylate cyclase (sGC), cyclic guanosine monophosphate (cGMP), and protein kinase G (PKG) and decreases the expression of endothelin-1 (ET-1). Metabolomics indicated SAL restored metabolic balance in PAH rats, particularly in arginine metabolism.ConclusionsSAL alleviates PAH by modulating arginine metabolism, enhancing NO synthesis, and improving pulmonary vascular remodeling.
C1 [Li, Junfei; Zhang, Zengyu; Zheng, Xiaorong; Wang, Chunlei; Jiang, Jianwei; Zhang, Hongyan] Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med & Canc HIM, 1 Banshan East Rd,Gongshu Dist, Hangzhou 310022, Zhejiang, Peoples R China.
   [Zhu, Chenghui] Wannan Med Coll, Wuhu 241000, Anhui, Peoples R China.
C3 Zhejiang Cancer Hospital; Chinese Academy of Sciences; Wannan Medical
   College
RP Jiang, JW; Zhang, HY (corresponding author), Chinese Acad Sci, Zhejiang Canc Hosp, Hangzhou Inst Med & Canc HIM, 1 Banshan East Rd,Gongshu Dist, Hangzhou 310022, Zhejiang, Peoples R China.
EM jiangjw@zjcc.org.cn; zhanghy@zjcc.org.cn
RI ; Zhang, Hongyan/AAA-8335-2020; zhu, chenghui/JHT-5048-2023
OI Jiang, Jianwei/0000-0002-2509-7828; 
FU Zhejiang Pharmaceutical Association
FX Not applicable.
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NR 37
TC 8
Z9 9
U1 0
U2 8
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 0949-2321
EI 2047-783X
J9 EUR J MED RES
JI Eur. J. Med. Res.
PD AUG 17
PY 2024
VL 29
IS 1
AR 423
DI 10.1186/s40001-024-02016-x
PG 14
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA C9S4N
UT WOS:001292685000002
PM 39152472
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, T
   Jiang, KL
   Wu, DQ
   Zhou, L
   Shen, N
   Nan, BY
   Huang, XS
AF Wang, Tan
   Jiang, Kang-lun
   Wu, Da-quan
   Zhou, Lei
   Shen, Na
   Nan, Ben-yu
   Huang, Xin-sheng
TI Salidroside Protects Cochlear Hair Cells from Cisplatin-Induced Oxidate
   Stress through Activating PINK1/Parkin-Mediated Mitophagy
SO JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
LA English
DT Article
DE Salidroside; cisplatin; ototoxicity; PINK1; Parkin; mitophagy
AB Background: Cisplatin (Cis) is a common chemotherapy medication which is widely applied to treat various types of tumors. But ototoxicity caused by Cis is the major concern of its application. Salidroside (Sal) is the primary active component of Rhodiola rosea, which has multiple pharmacological effects, including anti-inflammatory and antioxidant. This study was performed to evaluate the protective effect and understand the potential mechanisms of Sal on Cis-induced ototoxicity. Methods: Neonatal cochlear explants and HEI-OC1 cells were adopted to construct the Cis damage model, and treated with Sal. The effects of Sal on HEI-OC1 cells viability were detected using Cell Counting Kit-8 (CCK-8) and Adenosine Triphosphate (ATP) assay. The mitochondrial membrane potentials (MMPs) and the cellular and mitochondrial reactive oxygen species (ROS) levels in HEI-OC1 cells were evaluated. The hair cells in neonatal cochlear explants were labeled using immunofluorescence. The protein related to phosphatase and tensin homolog deleted on chromosome ten (PTEN) induced putative kinase 1 (PINK1)/Parkin pathway was detected by western blot. The neonatal cochlear explants and HEI-OC1 cells were incubated with mitochondrial division inhibitor 1 (Mdivi-1). The changes in cell viability and ROS level in HEI-OC1 cells and the number of hair cells in neonatal cochlear explants were examined. Results: Sal increased the cell viability and MMPs, and inhibited the cellular and mitochondrial ROS levels in Cis-induced HEIOC1 cells. Besides, Sal increased the number of hair cells, and enhanced the PINK1/Parkin pathway-mediated mitophagy in neonatal cochlear explants induced by Cis. Mdivi-1 reversed the protective effect of Sal on ototoxicity caused by Cis. Conclusions: Sal promotes mitochondrial autophagy by activating the PINK1/Parkin pathway. It protects hair cells from Cisinduced ototoxicity by scavenging ROS accumulation.
C1 [Wang, Tan; Jiang, Kang-lun; Wu, Da-quan; Zhou, Lei; Shen, Na; Huang, Xin-sheng] Fudan Univ, Zhongshan Hosp, Dept Otorhinolaryngol Head & Neck Surg, Shanghai 200032, Peoples R China.
   [Nan, Ben-yu] Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Dept Otorhinolaryngol Head & Neck Surg, Wenzhou 325000, Zhejiang, Peoples R China.
C3 Fudan University; Wenzhou Medical University
RP Huang, XS (corresponding author), Fudan Univ, Zhongshan Hosp, Dept Otorhinolaryngol Head & Neck Surg, Shanghai 200032, Peoples R China.; Nan, BY (corresponding author), Wenzhou Med Univ, Affiliated Hosp & Yuying Childrens Hosp 2, Dept Otorhinolaryngol Head & Neck Surg, Wenzhou 325000, Zhejiang, Peoples R China.
EM Benyu2003@icloud.com; Huang.xinsheng@zs-hospital.sh.cn
RI Shen, Na/IUO-3617-2023; Nan, Benyu/B-6539-2012
OI Nan, Benyu/0000-0002-1824-8827
FU Shanghai Science and Technology Committee Foundation [21Y31900500];
   Medical Health Science and Technology Project of Zhejiang Provincial
   Health Commission [2023RC047]; Chinese National Natural Science
   Foundation [82000980]; Key Project of National Natural Science
   Foundation of China [11932010]
FX This study is supported by Shanghai Science and Technology Committee
   Foundation, grant number 21Y31900500; Medical Health Science and
   Technology Project of Zhejiang Provincial Health Commission, grant
   number 2023RC047; Chinese National Natural Science Foundation, grant
   number 82000980; Key Project of National Natural Science Foundation of
   China, grant number 11932010.
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NR 36
TC 0
Z9 0
U1 0
U2 5
PU BIOLIFE SAS
PI SILVA MARINA (TE)
PA VIA S STEFANO 39 BIS, 64029 SILVA MARINA (TE), ITALY
SN 0393-974X
EI 1724-6083
J9 J BIOL REG HOMEOS AG
JI J. Biol. Regul. Homeost. Agents
PY 2023
VL 37
IS 11
BP 6329
EP 6340
DI 10.23812/j.biol.regul.homeost.agents.20233711.601
PG 12
WC Endocrinology & Metabolism; Immunology; Medicine, Research &
   Experimental; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Research & Experimental
   Medicine; Physiology
GA Z6HL0
UT WOS:001113065700001
OA hybrid
DA 2026-05-27
ER

PT J
AU You, LJ
   Zhang, D
   Geng, H
   Sun, FY
   Lei, M
AF You, Lijiao
   Zhang, Di
   Geng, Huan
   Sun, Fangyuan
   Lei, Ming
TI Salidroside protects endothelial cells against LPS-induced inflammatory
   injury by inhibiting NLRP3 and enhancing autophagy
SO BMC COMPLEMENTARY MEDICINE AND THERAPIES
LA English
DT Article
DE Sepsis; Salidroside (SAL); Human umbilical vein endothelial cells
   (HUVECs); Lipopolysaccharide (LPS); Apoptosis; Inflammation; NOD-like
   receptor protein 3 (NLRP3); Autophagy
ID ACUTE LUNG INJURY; NF-KAPPA-B; SEPSIS; ACTIVATION; PATHWAYS
AB Background Salidroside (SAL) is a bioactive compound extracted from Rhodiola rosea with various biological properties. This study was designed to explore the functions of SAL on the endothelial damage induced by lipopolysaccharide (LPS) and its related mechanisms. Methods Human umbilical vein endothelial cells (HUVECs) were pretreated with SAL (0, 10, 25, 50, 100 mu M), and then incubated with LPS (10 mu g/mL). Cell viability was evaluated by MTT assay, cell injury by lactate dehydrogenase (LDH) release, and inflammatory cytokines release by ELISA assay. Oxidative stress was evaluated by malondialdehyde (MDA) and superoxide dismutase (SOD) in cell lysate. Apoptosis was detected by flow cytometry and caspase-3 activity. Western blot were performed to determine expression levels of autophagy and NOD-like receptor protein 3 (NLRP3) related proteins. Results SAL at 50 mu M concentration showed no toxicity on HUVECs, but attenuated LPS-induced injury, as evidenced by increased cell viability, reduction in LDH level and inflammatory cytokines in culture media. SAL also reduced MDA level and increased SOD activity in HUVECs, and inhibited apoptosis rate and caspase-3 activity. (P < 0.05). Moreover, LPS enhanced HUVECs autophagy, and SAL pretreatment further enhanced autophagy, with increased Beclin-1 protein and decreased P62 protein. SAL also attenuated LPS-induced activation of NLRP3 inflammasome, reduced the protein expression of NLRP3-related proteins, including ASC and caspase-1. Autophagy inhibition by 3-MA markedly reversed SAL-modulated changes in cell viability and NLRP3 expression in LPS-stimulated HUVECs. Conclusion SAL protects endothelial cells against LPS-induced injury through inhibition of NLRP3 pathways and enhancing autophagy.
C1 [You, Lijiao; Geng, Huan; Sun, Fangyuan; Lei, Ming] Shanghai Univ TCM, Peoples Hosp 7, Dept Crit Care Med, 358 Datong Rd, Shanghai 200137, Peoples R China.
   [Zhang, Di] Shanghai Univ TCM, Peoples Hosp 7, Dept Rehabil Med, Shanghai 200137, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine
RP Lei, M (corresponding author), Shanghai Univ TCM, Peoples Hosp 7, Dept Crit Care Med, 358 Datong Rd, Shanghai 200137, Peoples R China.
EM leimsh@163.com
FU National Natural Science Foundation of China [81973649]; Outstanding
   Clinical Discipline Project of Shanghai Pudong [PWYgy2018-01]; Leading
   Medical Talent Training Program of Pudong Health Bureau of Shanghai
   [PWR12019-02]; Talents Training Program of Seventh People's Hospital of
   Shanghai University of TCM [XX2020-15]
FX This study was financially supported by (1) National Natural Science
   Foundation of China (Grant No: 81973649); (2) The Outstanding Clinical
   Discipline Project of Shanghai Pudong (Grant No: PWYgy2018-01); (3)
   Leading Medical Talent Training Program of Pudong Health Bureau of
   Shanghai (Grant No: PWR12019-02); (4) Talents Training Program of
   Seventh People's Hospital of Shanghai University of TCM (Grant No:
   XX2020-15).
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NR 35
TC 34
Z9 40
U1 0
U2 28
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2662-7671
J9 BMC COMPLEMENT MED
JI BMC Complement. Med. Ther.
PD MAY 19
PY 2021
VL 21
IS 1
AR 146
DI 10.1186/s12906-021-03307-0
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA SL6WU
UT WOS:000657056800002
PM 34011327
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU He, Y
   Ma, MD
   Yan, YG
   Chen, C
   Luo, H
   Lei, W
AF He, Yuan
   Ma, Mudi
   Yan, Yiguang
   Chen, Can
   Luo, Hui
   Lei, Wei
TI Combined pre-conditioning with salidroside and hypoxia improves
   proliferation, migration and stress tolerance of adipose-derived stem
   cells
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE adipose-derived stem cells; hypoxia; oxidative stress; salidroside; stem
   cell function
ID ENHANCES SURVIVAL; AUTOPHAGY; DEATH; ERK; TISSUE; AKT; DIFFERENTIATION;
   INVOLVEMENT; ENGRAFTMENT; ACTIVATION
AB Oxidative stress after ischaemia impairs the function of transplanted stem cells. Increasing evidence has suggested that either salidroside (SAL) or hypoxia regulates growth of stem cells. However, the role of SAL in regulating function of hypoxia-pre-conditioned stem cells remains elusive. Thus, this study aimed to determine the effect of SAL and hypoxia pre-conditionings on the proliferation, migration and tolerance against oxidative stress in rat adipose-derived stem cells (rASCs). rASCs treated with SAL under normoxia (20% O-2) or hypoxia (5% O-2) were analysed for the cell viability, proliferation, migration and resistance against H2O2-induced oxidative stress. In addition, the activation of Akt, Erk1/2, LC3, NF-kappa B and apoptosis-associated pathways was assayed by Western blot. The results showed that SAL and hypoxia treatments synergistically enhanced the viability (fold) and proliferation of rASCs under non-stressed conditions in association with increased autophagic flux and activation of Akt, Erk1/2 and LC3. H2O2-induced oxidative stress, cytotoxicity, apoptosis, autophagic cell death and NF-kappa B activation were inhibited by SAL or hypoxia, and further attenuated by the combined SAL and hypoxia pre-treatment. The SAL and hypoxia pre-treatment also enhanced the proliferation and migration of rASCs under oxidative stress in association with Akt and Erk1/2 activation; however, the combined pre-treatment exhibited a more profound enhancement in the migration than proliferation. Our data suggest that SAL combined with hypoxia pre-conditioning may enhance the therapeutic capacity of ASCs in post-ischaemic repair.
C1 [He, Yuan; Ma, Mudi; Chen, Can; Lei, Wei] Guangdong Med Univ, Lab Cardiovasc Dis, 57 Renmin Southern Rd, Zhanjiang 524001, Guangdong, Peoples R China.
   [Ma, Mudi; Yan, Yiguang; Lei, Wei] Guangdong Med Univ, Affiliated Hosp, Cardiovasc Med Ctr, 57 Renmin Southern Rd, Zhanjiang 524001, Guangdong, Peoples R China.
   [Luo, Hui; Lei, Wei] Guangdong Med Univ, Marine Biomed Res Inst, Southern Marine Sci & Engn Guangdong Lab Zhanjian, 2 Wenming Eastern Rd, Zhanjiang 524001, Guangdong, Peoples R China.
C3 Guangdong Medical University; Guangdong Medical University; Southern
   Marine Science & Engineering Guangdong Laboratory; Southern Marine
   Science & Engineering Guangdong Laboratory (Zhanjiang); Guangdong
   Medical University
RP Lei, W (corresponding author), Guangdong Med Univ, Lab Cardiovasc Dis, 57 Renmin Southern Rd, Zhanjiang 524001, Guangdong, Peoples R China.; Chen, C (corresponding author), Guangdong Med Univ, Affiliated Hosp, Cardiovasc Med Ctr, 57 Renmin Southern Rd, Zhanjiang 524001, Guangdong, Peoples R China.; Luo, H (corresponding author), Guangdong Med Univ, Marine Biomed Res Inst, Southern Marine Sci & Engn Guangdong Lab Zhanjian, 2 Wenming Eastern Rd, Zhanjiang 524001, Guangdong, Peoples R China.
EM chencan-21@126.com; luohui@gdmu.edu.cn; leiwei2006@126.com
OI Lei, Wei/0000-0002-4033-4799
FU Natural Science Foundation of Guangdong Province [2019A1515011925];
   Competitive Key Scientific and Technological Program of Zhanjiang
   Municipal Financial Fund [2018A01023]; Southern Marine Science and
   Engineering Guangdong Laboratory Zhanjiang [ZJW-2019-07]; Stem Cell
   Preclinical Research Projects of the Affiliated Hospital of Guangdong
   Medical University [2018PSSC004]; Guangdong Provincial Bureau of
   Traditional Chinese Medicine [20182068]; National Natural Science
   Foundation of China [81700269, 81970056]
FX Natural Science Foundation of Guangdong Province, Grant/Award Number:
   2019A1515011925; Competitive Key Scientific and Technological Program of
   Zhanjiang Municipal Financial Fund, Grant/Award Number: 2018A01023;
   Southern Marine Science and Engineering Guangdong Laboratory Zhanjiang,
   Grant/Award Number: ZJW-2019-07; Stem Cell Preclinical Research Projects
   of the Affiliated Hospital of Guangdong Medical University, Grant/Award
   Number: 2018PSSC004; Project of Guangdong Provincial Bureau of
   Traditional Chinese Medicine, Grant/Award Number: 20182068; National
   Natural Science Foundation of China, Grant/Award Number: 81700269 and
   81970056
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NR 47
TC 5
Z9 6
U1 2
U2 16
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1582-1838
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD SEP
PY 2020
VL 24
IS 17
BP 9958
EP 9971
DI 10.1111/jcmm.15598
EA AUG 2020
PG 14
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA NT3AD
UT WOS:000556458400001
PM 32767741
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, JX
   Cai, JP
   Fan, P
   Zhang, NS
   Cao, YG
AF Liu, Jiuxi
   Cai, Jiapei
   Fan, Peng
   Zhang, Naisheng
   Cao, Yongguo
TI The Abilities of Salidroside on Ameliorating Inflammation, Skewing the
   Imbalanced Nucleotide Oligomerization Domain-Like Receptor Family Pyrin
   Domain Containing 3/Autophagy, and Maintaining Intestinal Barrier Are
   Profitable in Colitis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; colitis; NLRP3 inflammasome; autophagy; intestinal barrier;
   inflammation
ID SODIUM-INDUCED COLITIS; ULCERATIVE-COLITIS; INHIBITION; ACTIVATION;
   AUTOPHAGY; DISEASE; PROTEIN; INJURY; MICE
AB Salidroside (Sal), as a major glycoside extracted from Rhodiola rosea L., has exhibited its mighty anti-aging, anti-oxidant, anti-cancer, anti-inflammation, and neuroprotective effects in many diseases. Recently, it has showed its protective effect in colitis mice by activating the SIRT1/FoxOs pathway. Whereas, it is not known whether Sal has other protective mechanisms on dextran sulfate sodium (DSS)-induced colitis in mice. In this study, we investigated the protective effects and mechanisms of Sal on DSS-induced colitis in mice. The results demonstrated Sal was a competent candidate in the treatment of ulcerative colitis (UC). Sal remitted DSS-induced disease activity index (DAI), colon length shortening, and colonic pathological damage. Simultaneously, Sal alleviated excessive inflammation by reversing the IL-1 beta, TNF-alpha, and IL-10 protein levels in DSS-treated mice. Western blot analysis revealed that Sal inhibited p65 and p38 activation together with peroxisome proliferator-activated receptor (PPAR gamma) up-regulation. In addition, Sal skewed the imbalanced activation of nucleotide oligomerization domain-like receptor family pyrin domain containing 3 inflammasome and autophagy contributing to colitis recovery. The damaged intestinal barrier induced by DSS was also alleviated along with plasma lipopolysaccharides (LPS) reduction after Sal treatment. In vitro, Sal showed PPAR gamma-dependent anti-inflammatory effect in LPS-stimulated RAW264.7 cells. In summary, our results demonstrated that Sal might be an effective factor for UC treatment and its pharmacological value deserved further development.
C1 [Liu, Jiuxi; Cai, Jiapei; Fan, Peng; Zhang, Naisheng; Cao, Yongguo] Jilin Univ, Coll Vet Med, Dept Clin Vet Med, Changchun, Jilin, Peoples R China.
C3 Jilin University
RP Zhang, NS; Cao, YG (corresponding author), Jilin Univ, Coll Vet Med, Dept Clin Vet Med, Changchun, Jilin, Peoples R China.
EM zhangns@jlu.edu.cn; ygcao82@jlu.edu.cn
RI Fan, Peng/OIS-5642-2025
FU Key Project of Chinese National Programs for Research and Development
   [2016YFD0501009]; National Natural Science Foundation of China
   [31572582, 31472248]
FX This work was supported by the Key Project of Chinese National Programs
   for Research and Development (no. 2016YFD0501009) and National Natural
   Science Foundation of China (nos. 31572582 and 31472248).
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TC 34
Z9 40
U1 0
U2 30
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD DEC 2
PY 2019
VL 10
AR 1385
DI 10.3389/fphar.2019.01385
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA JW0JR
UT WOS:000502746200001
PM 31849652
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, HM
   Shen, L
   Lv, TL
   Wang, R
   Zhang, N
   Peng, H
   Diao, WX
AF Li, Huimin
   Shen, Lei
   Lv, Tingling
   Wang, Ru
   Zhang, Na
   Peng, Hao
   Diao, Wenxiu
TI Salidroside attenuates dextran sulfate sodium-induced colitis in mice
   via SIRT1/FoxOs signaling pathway
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Salidroside; SIRT1/FoxOs pathway; Colitis; Oxidative stress; Apoptosis
ID INFLAMMATORY-BOWEL-DISEASE; ULCERATIVE-COLITIS; OXIDATIVE STRESS;
   MECHANISMS; SIRTUINS; INSIGHTS; SIRT1
AB Salidroside (Sal), the active ingredient of Rhodiola rosea L, has various pharmacological activities, including antioxidant, anti-inflammatory and anti-tumor activities. Recently, studies have shown that oxidative stress and apoptosis are related to the pathogenesis of inflammatory bowel disease. Therefore, we evaluated the effects of Sal on oxidative stress and apoptosis in colitis mice through the SIRT1/FoxOs pathway. To induce the colitis model, mice continuously consumed water containing 3% DSS for 7 days; some mice were also treated with Sal and the SIRT1/FoxOs pathway blocker selisistat (Ex527). Changes in body weight, DAI, colon length and colon tissue histology as well as SOD, GSH-Px and CAT activities were measured. The expression of SIRT1, FoxO1, FoxO3a, FoxO4, caspase-3, cleaved-caspase-3, Bax and Bcl-2 in colorectal tissues was detected by RT-PCR and Western blotting. The study showed that Sal decreased the DAI score, weight loss, colon shortening and colon tissue damage in colitis mice. Sal inhibited oxidative stress by upregulating SOD, GSH-Px and CAT while suppressing colonic apoptosis by downregulating the expression of Bax, caspase-3, and cleaved-caspase-3 and upregulating the expression of Bcl-2. Sal also activated SIRT1/FoxOs signaling, which increased the expression of SIRT1, FoxO1, FoxO3a and FoxO4 in colon tissue. Furthermore, SIRT1/FoxOs pathway inhibition using Ex527 partially eliminated the effect of Sal on colitis mice. The study manifested that Sal may protect colitis mice by activating the SIRT1/FoxOs pathway, which is related to oxidative stress and apoptosis in colon tissues.
C1 [Li, Huimin; Shen, Lei] Wuhan Univ, Renmin Hosp, Hubei Key Lab Digest Syst Dis, Wuhan 430060, Hubei, Peoples R China.
   [Lv, Tingling; Wang, Ru; Zhang, Na; Peng, Hao; Diao, Wenxiu] Wuhan Univ, Renmin Hosp, Wuhan 430060, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University
RP Shen, L (corresponding author), Wuhan Univ, Renmin Hosp, Hubei Key Lab Digest Syst Dis, Wuhan 430060, Hubei, Peoples R China.
EM 15018530997@163.com
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NR 31
TC 33
Z9 39
U1 3
U2 68
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD OCT 15
PY 2019
VL 861
AR 172591
DI 10.1016/j.ejphar.2019.172591
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA IU9YM
UT WOS:000483936600020
PM 31401159
DA 2026-05-27
ER

PT J
AU Zhong, XY
   Lin, RH
   Li, ZF
   Mao, JJ
   Chen, LD
AF Zhong, Xiaoyong
   Lin, Ruhui
   Li, Zuanfang
   Mao, Jingjie
   Chen, Lidian
TI Effects of Salidroside on Cobalt Chloride-Induced Hypoxia Damage
   and mTOR Signaling Repression in PC12 Cells
SO BIOLOGICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE salidroside; ischemic; mammalian target of rapamycin (mTOR); hypoxia;
   cobalt chloride; PC12 cell
ID PEROXIDE-INDUCED INJURY; MAMMALIAN TARGET; INDUCED APOPTOSIS; RAPAMYCIN;
   PROTEIN; KINASE; INHIBITION; GROWTH; ROS; INDUCTION
AB Salidroside (SA), a phenylpropanoid glycoside isolated from Rhodiola rosea L., has been documented to exert a broad spectrum of pharmacological properties, including protective effects against neuronal death induced by various stresses. To provide further insights into the neuroprotective functions of SA, this study examined whether SA can attenuate cobalt chloride (CoCl2)-induced hypoxia damage and mammalian target of rapamycin (mTOR) signaling repression in PC12 differentiated cells. Differentiated PC12 cells were exposed to CoCl2 for 12 h to mimic hypoxic/ischemic conditions and treated with SA at the same time, followed by electron microscopy and analysis of cell viability, intracellular reactive oxygen species (ROS) level, hypoxia-inducible factor-1 alpha (HIF-1 alpha) level, and the regulated in development and DNA damage responses (REDD1)/mTOR/ p70 ribosomal S6 kinase (p70S6K) signaling pathway. Our data indicated that SA can dramatically attenuate the ultrastructural damage of mitochondria induced by CoCl2 and significantly decrease CoCl2-induced ROS production. Moreover, phosphorylated mammalian target of rapamycin (p-mTOR) was significantly reduced by CoCl2, and this inhibition was relieved by the treatment of SA in PC12 cells, as evidenced by immunoblot and quantitative reverse transcription-polymerase chain reaction (qRT-PCR) analyses. The SA effects were blocked by pretreatment of RAD001. The results indicate that SA can rescue CoCl2-induced repression of REDD1/mTOR/ p70S6K signal transduction in PC12 cells. Our data demonstrate that SA is able to attenuate CoCl2-induced hypoxia damage and mTOR signaling repression, suggesting that SA may protect brain neurons from ischemic injury through mTOR signaling, and provide new insights into the prevention and treatment of cerebral ischemic.
C1 [Zhong, Xiaoyong; Chen, Lidian] Fujian Univ Tradit Chinese Med, Coll Rehabil Med, Fuzhou 350122, Fujian, Peoples R China.
   [Zhong, Xiaoyong; Chen, Lidian] Fujian Univ Tradit Chinese Med, Key Lab TCM Rehabil State Adm Tradit Chinese Med, Fuzhou 350122, Fujian, Peoples R China.
   [Lin, Ruhui; Chen, Lidian] Fujian Univ Tradit Chinese Med, MOE Key Lab Tradit Chinese Med Osteol & Traumatol, Fuzhou 350122, Fujian, Peoples R China.
   [Zhong, Xiaoyong; Lin, Ruhui; Li, Zuanfang; Mao, Jingjie] Fujian Univ Tradit Chinese Med, Acad Integrat Med, Fuzhou 350122, Fujian, Peoples R China.
C3 Fujian University of Traditional Chinese Medicine; Fujian University of
   Traditional Chinese Medicine; Fujian University of Traditional Chinese
   Medicine; Fujian University of Traditional Chinese Medicine
RP Chen, LD (corresponding author), Fujian Univ Tradit Chinese Med, Coll Rehabil Med, 1 Huatuo Rd, Fuzhou 350122, Fujian, Peoples R China.
EM cld@fjtcm.edu.cn
RI Chen, Lidian/GSN-6461-2022; Chen, Lidian/GSN-6461-2022
OI Chen, Lidian/0000-0002-6454-7932; Chen, Lidian/0000-0002-8699-0839
FU National Natural Science Foundation of China [81273835]
FX This study was supported by Grants from the National Natural Science
   Foundation of China (No. 81273835). We thank Dr. Guangpu Li, University
   of Oklahoma Health Sciences Center, for critical reading of the
   manuscript.
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NR 50
TC 45
Z9 57
U1 0
U2 36
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0918-6158
J9 BIOL PHARM BULL
JI Biol. Pharm. Bull.
PD JUL
PY 2014
VL 37
IS 7
BP 1199
EP 1206
DI 10.1248/bpb.b14-00100
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AK2SM
UT WOS:000338269800017
PM 24989011
OA gold
DA 2026-05-27
ER

PT J
AU Zhang, ZY
   Ding, LM
   Wu, LQ
   Xu, LY
   Zheng, LZ
   Huang, XM
AF Zhang, Zhuoyi
   Ding, Limin
   Wu, Liqun
   Xu, Liying
   Zheng, Lanzhi
   Huang, Xiaomin
TI Salidroside alleviates paraquat-induced rat acute lung injury by
   repressing TGF-β1 expression
SO INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY
LA English
DT Article
DE Salidroside; paraquat; acute lung injury; transforming growth
   factor-beta 1
ID PULMONARY-FIBROSIS; RHODIOLA-ROSEA; GROWTH; MICE; MEDIATOR; PATHWAY;
   BETA; HPV
AB Objective: This study was designed to investigate the protective effects of salidroside (SDS) via suppressing the expression of transforming growth factor-beta 1 (TGF-beta 1) in rat acute lung injury (ALI) induced by paraquat (PQ) and to explore the potential molecular mechanisms. Methods: A total of 90 male rats (190-210 g) were randomly and evenly divided into 9 groups: control group, PQ groups (4 groups), and PQ + SDS groups (4 groups). The rats in control group were treated with equal volume of saline intraperitoneally. The rats in PQ groups were exposed to PQ solution (20 mg/kg) by gastric gavage for 1, 6, 24, and 72 hours, respectively. The rats in PQ + SDS groups were intraperitoneally injected once with SDS (10 mg/kg) every 12 hours after PQ perfusion. Pulmonary pathological changes were observed by hematoxylin and eosin (HE) staining. The expression of TGF-beta 1 and the mRNA were evaluated by immunohistochemical (IHC) scoring and real time quantitative reverse transcription polymerase chain reaction (real-time qRT-PCR), respectively. Results: SDS alleviated the symptoms of PQ induced ALI. Moreover, SDS reduced the expression of the inflammatory cytokine TGF-beta 1 including TGF-beta 1 IHC scores (at each time point from 6 to 72 hours after PQ perfusion) and mRNA level (at each time point from 1 to 72 hours after PQ perfusion) compared with PQ groups (P < 0.05). Conclusion: SDS alleviated the pulmonary symptoms of PQ-induced ALI, at least partially, by repressing inflammatory cell infiltration and the expression of TGF-beta 1 resulting in delayed lung fibrosis.
C1 [Zhang, Zhuoyi; Ding, Limin; Xu, Liying; Zheng, Lanzhi; Huang, Xiaomin] Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Emergency, Hangzhou 310006, Zhejiang, Peoples R China.
   [Wu, Liqun] Taizhou Cent Hosp, Dept Emergency, Taizhou 318000, Zhejiang, Peoples R China.
C3 Zhejiang Chinese Medical University; Taizhou University
RP Zhang, ZY (corresponding author), Zhejiang Chinese Med Univ, Affiliated Hosp 1, Dept Emergency, Youdian Rd 54, Hangzhou 310006, Zhejiang, Peoples R China.
EM ZhangZhuoyi123@hotmail.com
RI Huang, Xiaomin/GYJ-5985-2022
FU Scientific Research Fund of Zhejiang Province Chinese Medicine
   [2012ZB039, 2013ZA056]; Zhejiang Medicines and Health Sciences Research
   Foundation [2013KYA141]
FX We wish to express our warm thanks to all the authors who contributed to
   the research. The research was supported by the Scientific Research Fund
   of Zhejiang Province Chinese Medicine (2012ZB039, 2013ZA056) and
   Zhejiang Medicines and Health Sciences Research Foundation (2013KYA141).
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NR 34
TC 29
Z9 34
U1 0
U2 8
PU E-CENTURY PUBLISHING CORP
PI MADISON
PA 40 WHITE OAKS LN, MADISON, WI 53711 USA
SN 1936-2625
J9 INT J CLIN EXP PATHO
JI Int. J. Clin. Exp. Pathol.
PY 2014
VL 7
IS 12
BP 8841
EP 8847
PG 7
WC Oncology; Pathology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Pathology
GA AZ6RG
UT WOS:000348345900057
PM 25674253
DA 2026-05-27
ER

PT J
AU Ouyang, XL
   Wei, LX
   Wang, HS
   Pan, YM
AF Ouyang, X. -L
   Wei, L. -X.
   Wang, H. -S.
   Pan, Y. -M.
TI Antioxidant activity and phytochemical composition of Osmanthus
   fragrans' pulps
SO SOUTH AFRICAN JOURNAL OF BOTANY
LA English
DT Article
DE Osmanthus fragrans; Phytochemical constituents; Antioxidant activity
ID OLIVE OIL; JASMINUM-POLYANTHUM; NATURAL ANTIOXIDANT; HYDROXYTYROSOL;
   CHROMATOGRAPHY; GLUCOSIDES; SEEDS; L.
AB Purification of the ethanol extract of Osmanthus fragrans' pulps led to the isolation of eleven compounds, namely 5-hydroxymethylfurfural (1), hydroxytyrosol (2), pinoresinol (3), oleoside-7,11-dimethyl ester (4), oleoside-11-methyl ester (5), verbenalin (6), phillyrin (7), salidroside (8), beta-sitosterol (9), octadecanoic acid (10), and octane (11). Their structures were identified by mass and various nuclear magnetic resonance spectroscopic techniques. All compounds except for 5, 7, and 9 were isolated from O. fragrans for the first time. Ethanol extract and its fractions of O. fragrans' pulps were investigated for their antioxidant properties using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2',2'-azinobis (3-ethylbenzothiazline-6-sulfonic acid) (ABTS) radical scavenging capacity assay, and ferric reducing antioxidant potential (FRAP) assay. Based on the antioxidant experiments of crude ethanol extract and its fractions, n-butanol fraction shows the best antioxidant activity, salidroside and phillyrin may be the highest contributors and responsible for the antioxidant activity in the n-butanol fraction. (C) 2015 SAAB. Published ly Elsevier B.V. All rights reserved.
C1 [Ouyang, X. -L; Wei, L. -X.; Wang, H. -S.; Pan, Y. -M.] Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Cultivat Base Chem & Mol Engn Med R, Guilin 541004, Peoples R China.
   [Ouyang, X. -L] Youjiang Med Univ Nationalities, Baise 533000, Peoples R China.
C3 Guangxi Normal University; Youjiang Medical University for Nationalities
RP Wang, HS (corresponding author), Guangxi Normal Univ, Sch Chem & Pharmaceut Sci, State Key Lab Cultivat Base Chem & Mol Engn Med R, Guilin 541004, Peoples R China.
EM hengshan_wang@yahoo.com; panym2013@hotmail.com
RI Ouyang, Xi-Lin/S-1412-2019
FU National Natural Science Foundation of China [81260472, 21101035];
   Guangxi Natural Science Foundation of China [2012GXNSFAA053027]; Guangxi
   Key Laboratory of Functional Phytochemicals Research and Utilization
   [FPRU2013-7]
FX We thank Prof. Shaoqing Tang for the identification of O. fragrans'
   fruits. This project was supported by the grant from the National
   Natural Science Foundation of China (81260472 and 21101035), the Guangxi
   Natural Science Foundation of China (2012GXNSFAA053027), and the Fund of
   Guangxi Key Laboratory of Functional Phytochemicals Research and
   Utilization (FPRU2013-7).
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NR 21
TC 30
Z9 31
U1 3
U2 55
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0254-6299
EI 1727-9321
J9 S AFR J BOT
JI S. Afr. J. Bot.
PD MAY
PY 2015
VL 98
BP 162
EP 166
DI 10.1016/j.sajb.2015.03.180
PG 5
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA CG9CP
UT WOS:000353612300023
OA hybrid
DA 2026-05-27
ER

PT J
AU Huang, R
   Yong, X
   Li, TT
   Wen, HL
   Zhou, X
   Liao, YC
   You, J
   Yu, CL
   Xu, P
   Wang, YQ
   Wen, D
   Xia, TQ
   Yang, H
   Chen, YQ
   Xu, L
   Zhong, XR
   Li, XF
   Xu, ZM
   Zhou, CY
AF Huang, Rong
   Yong, Xi
   Li, Tingting
   Wen, Huling
   Zhou, Xing
   Liao, Yichen
   You, Jun
   Yu, Chunlei
   Xu, Peng
   Wang, Yuquan
   Wen, Dan
   Xia, Tianqin
   Yang, Hao
   Chen, Yanqin
   Xu, Lei
   Zhong, Xiaorong
   Li, Xianfu
   Xu, Zhengmin
   Zhou, Chunyang
TI 15-Lipoxygenase-2 deficiency induces foam cell formation that can
   be restored by salidroside through the inhibition of arachidonic acid
   effects
SO OPEN LIFE SCIENCES
LA English
DT Article
DE 15-lipoxygenase-2; foam cell formation; macrophages; arachidonic acid;
   salidroside
ID INFLAMMATION
AB 15-Lipoxygenase-2 (15-Lox-2) is one of the key enzymes in arachidonic acid (AA) metabolic pathway, which belongs to the unsaturated fatty acid metabolic pathway. This pathway is involved in the foam cell transformation of macrophages during the progression of atherosclerosis (AS). The role of salidroside (SAL) in cardiovascular diseases has been extensively studied, but its impact on macrophage foam cell formation has not yet been clearly clarified. We aimed to determine the effects of 15-Lox-2 deficiency on macrophage (Ana-1 cell) foam cell formation, and those of SAL on 15-Lox-2-deficient macrophages. 15-Lox-2-deficient macrophages were generated using short hairpin RNA. Results indicated that 15-Lox-2 expression in the aorta of atherosclerotic patients is lower than that of the normal group. Additionally, 15-Lox-2 deficiency dramatically promoted macrophage uptake of oxidized low-density lipoprotein (ox-LDL) and increased the Cyclin D1 level while dramatically decreasing caspase3 expression. Furthermore, inflammation, complement, and TNF-alpha signaling pathways, along with IL1 alpha, IL1 beta, IL18, and Cx3cl1, were activated in 15-Lox-2-deficient macrophages. These changes were alleviated by SAL through inhibiting AA effects, and the effects of AA on macrophages could be inhibited by SAL. Consistently, phospholipase A2-inhibitor arachidonyl trifluoromethyl ketone (AACOCF3) restored these changes. In summary, SAL reversed the effects of 15-Lox-2 deficiency on macrophages by inhibiting excessive AA and may be a promising therapeutic potential in treating atherosclerosis resulting from 15-Lox-2 deficiency.
C1 [Huang, Rong; Liao, Yichen; You, Jun; Yu, Chunlei; Xia, Tianqin; Xu, Zhengmin; Zhou, Chunyang] North Sichuan Med Coll, Inst Mat Med, Sch Pharm, 234 Fujiang Rd, Nanchong 637000, Sichuan, Peoples R China.
   [Yong, Xi; Wen, Huling; Xu, Peng; Wang, Yuquan; Wen, Dan; Li, Xianfu] North Sichuan Med Coll, Affiliated Hosp, Dept Oncol, Dept Vasc Surg,Dept Nucl Med,Radiotherapy Dept, Nanchong, Sichuan, Peoples R China.
   [Li, Tingting] North Sichuan Med Coll, Affiliated Hosp 2, Dept Pharm, Nanchong, Sichuan, Peoples R China.
   [Zhou, Xing; Yang, Hao; Chen, Yanqin; Xu, Lei; Zhong, Xiaorong] North Sichuan Med Coll, Inst Hepatobiliary Res, Translat Med Res Ctr, Sch Basic Med Sci, Nanchong, Sichuan, Peoples R China.
C3 North Sichuan Medical University; North Sichuan Medical University;
   North Sichuan Medical University; North Sichuan Medical University
RP Xu, ZM; Zhou, CY (corresponding author), North Sichuan Med Coll, Inst Mat Med, Sch Pharm, 234 Fujiang Rd, Nanchong 637000, Sichuan, Peoples R China.
EM xu.zhengmin@163.com; zhouchunyang@nsmc.edu.cn
RI /AAO-7524-2020
FU Key project of North Sichuan Medical College [CBY21-ZD05]; Doctoral
   initiation fund of North Sichuan Medical College [740/75001013];
   Scientific Research Project of Nanchong Municipal Science and Technology
   Bureau, Sichuan Province [19SXHZ0443]; National College Student
   Innovation and Entrepreneurship Training Program Project
   [XJ202310634319, S202410634100]
FX Tis work was supported by pro-jects for the key project of North Sichuan
   Medical College(CBY21-ZD05), the Doctoral initiation fund of North
   Sichuan Medical College (740/75001013), Scientific Research Project of
   Nanchong Municipal Science and Technology Bureau, Sichuan Province
   (19SXHZ0443), and National College Student Innovation and
   Entrepreneurship Training Program Project (XJ202310634319 and
   S202410634100)
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NR 52
TC 1
Z9 1
U1 0
U2 1
PU DE GRUYTER POLAND SP Z O O
PI WARSAW
PA BOGUMILA ZUGA 32A STR, 01-811 WARSAW, MAZOVIA, POLAND
SN 2391-5412
J9 OPEN LIFE SCI
JI Open Life Sci.
PD APR 29
PY 2025
VL 20
IS 1
AR 20251091
DI 10.1515/biol-2025-1091
PG 13
WC Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Life Sciences & Biomedicine - Other Topics
GA 2AQ6Z
UT WOS:001478127600001
PM 40321157
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zuo, W
   Yan, F
   Zhang, B
   Hu, XM
   Mei, D
AF Zuo, Wei
   Yan, Feng
   Zhang, Bo
   Hu, Xiaomin
   Mei, Dan
TI Salidroside improves brain ischemic injury by activating PI3K/Akt
   pathway and reduces complications induced by delayed tPA treatment
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Salidroside; Cerebral ischemia; Blood-brain barrier; tPA
ID TISSUE-PLASMINOGEN ACTIVATOR; FOCAL CEREBRAL-ISCHEMIA; PROTEIN-C ANALOG;
   RHODIOLA-ROSEA-L.; OCCLUDIN DEGRADATION; THERAPEUTIC WINDOW; ACUTE
   STROKE; RAT MODEL; IN-VITRO; BARRIER
AB Cerebral ischemia causes blood-brain barrier (BBB) injury and thus increases the risk of complications secondary to thrombolysis, which limited its clinical application. This study aims to clarify the role and mechanism of salidroside (SALD) in alleviating brain ischemic injury and whether pretreatment of it could improve prognosis of delayed treatment of tissue plasminogen activator (t-PA). Rats were subjected to 3 h of middle cerebral artery occlusion (MCAO) and were intraperitoneally administered with 10, 20 or 40 mg/kg SALD before ischemia. 1.5% 5-triphenyl-2H-tetrazolium chloride (TTC) staining and neurological studies were performed to observe the effectiveness of SALD. The expressions and the distribution of phosphoinositide-3-kinase/protein kinase B (PI3K/Akt) signaling were analyzed. Experiments were further conducted in isolated microvessels and human brain microvascular endothelial cells (HBMECs) to explore the protective mechanism of SALD. Finally, rats were subjected to 6 h of MCAO and 24 h of reperfusion. tPA was given with or without the pretreatment of SALD. Various approaches including gelatin zymography, western blot and immunofluorescence were used to evaluate the effect of this combination therapy. SALD could reduce cerebral ischemic injury and enhance HBMECs viability subjected to OGD. In vivo and in vitro studies showed the mechanism might be related to the activation of PI3K/Akt signaling by phosphorylating Akt on Ser473. Pretreatment of SALD could alleviate BBB injury and improve the outcome of delayed treatment of tPA. These results provide evidence that SALD might be an effective adjuvant to reduce the complications induced by delayed tPA treatment for brain ischemia.
C1 [Zuo, Wei; Zhang, Bo; Hu, Xiaomin; Mei, Dan] Chinese Acad Med Sci, Peking Union Med Coll Hosp, Beijing, Peoples R China.
   [Zuo, Wei; Zhang, Bo; Hu, Xiaomin; Mei, Dan] Peking Union Med Coll, Beijing, Peoples R China.
   [Yan, Feng] Capital Mex Univ, Ctr Brain Disorders Res, Beijing, Peoples R China.
   [Yan, Feng] Beijing Inst Brain Disorders, Beijing, Peoples R China.
   [Yan, Feng] Capital Med Univ, Xuanwu Hosp, Cerebrovasc Dis Res Inst, Beijing, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College Hospital; Chinese Academy of Medical
   Sciences - Peking Union Medical College; Peking Union Medical College;
   Capital Medical University
RP Mei, D (corresponding author), Chinese Acad Med Sci, Peking Union Med Coll Hosp, Beijing, Peoples R China.; Mei, D (corresponding author), Peking Union Med Coll, Beijing, Peoples R China.
EM meidanpumch@163.com
RI Hu, Xiaomin/GQH-5077-2022
OI yan, feng/0000-0001-8663-6859
FU Beijing Natural Science Foundation [7174342]; National Natural Science
   Foundation of China [81601033, 81601431]; CAMS Innovation Fund for
   Medical Science [CAMS-2017-I2M-1-011]
FX This work was supported by funding from by Beijing Natural Science
   Foundation No. 7174342, National Natural Science Foundation of China
   Grants nos. 81601033, 81601431 and CAMS Innovation Fund for Medical
   Science (CAMS-2017-I2M-1-011).
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Z9 39
U1 1
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PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JUL 5
PY 2018
VL 830
BP 128
EP 138
DI 10.1016/j.ejphar.2018.04.001
PG 11
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GG7PR
UT WOS:000432890900015
PM 29626425
DA 2026-05-27
ER

PT J
AU Ma, YG
   Wang, JW
   Zhang, YB
   Wang, BF
   Dai, ZJ
   Xie, MJ
   Kang, HF
AF Ma, Yu-Guang
   Wang, Jun-Wei
   Zhang, Yin-Bin
   Wang, Bao-Feng
   Dai, Zhi-Jun
   Xie, Man-Jiang
   Kang, Hua-Feng
TI Salidroside improved cerebrovascular vasodilation in
   streptozotocin-induced diabetic rats through restoring the function of
   BKCa channel in smooth muscle cells
SO CELL AND TISSUE RESEARCH
LA English
DT Article
DE Salidroside; Relaxation; Vascular smooth muscle cells (VSMCs); Large
   conductance calcium-activated K+ channel (BKCa); beta(1)-subunit
ID ACTIVATED POTASSIUM CHANNELS; SIMULATED MICROGRAVITY;
   PULMONARY-HYPERTENSION; VASCULAR DYSFUNCTION; HYPERGLYCEMIA; APOPTOSIS;
   IMPAIRMENT; EXPRESSION; BERBERINE; RHODIOLA
AB Vessel disease is a kind of severe complication in diabetic patients. However, few pharmacologic agents can directly recover diabetic vascular function. Salidroside (SAL), a major ingredient from Rhodiola rosea, has been found to have an obvious hypoglycemic effect and a beneficial protection on vascular function in diabetes. However, whether SAL is a suitable treatment for diabetes has not so far been evaluated and the underlying mechanisms remain unknown. The present work aims to (1) investigate the potential effects of SAL on cerebrovascular relaxation in streptozotocin-induced diabetic rats or when exposed to acute hyperglycemia condition and (2) examine whether function of the BKCa channel is involved in SAL treatment for diabetic vascular relaxation. Our results indicate that chronic administration of 100 mg/kg/day SAL not only improves cerebrovascular relaxation but also increases BKCa beta 1-subunit expressions at both protein and mRNA levels and enhances BKCa whole-cell and single-channel activities in cerebral VSMCs of diabetic rats. Correspondingly, acute application of 100 mu M SAL induces cerebrovascular relaxation by activation of the BKCa channel. Furthermore, SAL activated the BKCa channel mainly through acting on the beta 1-subunit in HEK293 cells transfected with hSlo alpha+beta 1 constructs. We concluded that SAL improved vasodilation in diabetic rats through restoring the function of the BKCa-beta 1 subunit in cerebrovascular smooth muscle cells, which may be the underlying mechanism responsible for the vascular protection of SAL in diabetes.
C1 [Ma, Yu-Guang; Zhang, Yin-Bin; Wang, Bao-Feng; Dai, Zhi-Jun; Kang, Hua-Feng] Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Oncol, Coll Med, Xian 710004, Shaanxi, Peoples R China.
   [Wang, Jun-Wei] Shaanxi Prov Peoples Hosp, Dept Cardiovasc Med, Xian 710068, Shaanxi, Peoples R China.
   [Xie, Man-Jiang] Fourth Mil Med Univ, Dept Aerosp Physiol, Key Lab Aerosp Med, Minist Educ, Xian 710032, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Medical University; Air Force Medical
   University
RP Kang, HF (corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 2, Dept Oncol, Coll Med, Xian 710004, Shaanxi, Peoples R China.; Xie, MJ (corresponding author), Fourth Mil Med Univ, Dept Aerosp Physiol, Key Lab Aerosp Med, Minist Educ, Xian 710032, Shaanxi, Peoples R China.
EM manjiangxie@hotmail.com; kanghuafeng1973@126.com
RI Zhang, Yingbin/J-2815-2013; Dai, Zhi-Jun/O-6826-2014
OI Dai, Zhi-Jun/0000-0001-5209-8626
FU National Natural Science Foundation of China [81471032, 31270904]
FX This work was supported by the National Natural Science Foundation of
   China (No. 81471032 and 31270904). The funders had no role in study
   design, data collection and analysis, decision to publish, or
   preparation of the manuscript.
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NR 42
TC 12
Z9 15
U1 0
U2 25
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0302-766X
EI 1432-0878
J9 CELL TISSUE RES
JI Cell Tissue Res.
PD DEC
PY 2017
VL 370
IS 3
BP 365
EP 377
DI 10.1007/s00441-017-2671-3
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA FN9LQ
UT WOS:000416358400003
PM 28803422
DA 2026-05-27
ER

PT J
AU Wang, CH
   Safwan, S
   Cheng, MC
   Liao, TY
   Cheng, LC
   Chen, TA
   Kuo, YH
   Lin, YF
   Lee, CK
AF Wang, Cheng-Hao
   Safwan, Safwan
   Cheng, Min-Chi
   Liao, Te-Yu
   Cheng, Lin-Chen
   Chen, Ting-An
   Kuo, Yueh-Hsiung
   Lin, Yung-Feng
   Lee, Ching-Kuo
TI Protective Evaluation of Compounds Extracted from Root ofRhodiola
   roseaL. against Methylglyoxal-Induced Toxicity in a Neuronal Cell
   Line
SO MOLECULES
LA English
DT Article
DE Rhodiola rosea; neuroprotective activity; acetylcholinesterase;
   methylglyoxal; neuro-2A
ID RHODIOLA-ROSEA; INDUCED APOPTOSIS; SALIDROSIDE; INHIBITION; COMPONENTS;
   GROWTH; DEATH; ARRAY
AB Rhodiola roseaL. (R. rosea) is one of the most beneficial medicinal plants and it is studied as an adaptogen. This study aims to evaluate the neuroprotective activity of compounds extracted from the root ofR. roseaagainst methylglyoxal (MG)-induced apoptosis in neuro-2A (N2A) cells. The root ofR. roseawas extracted with ethanol and partitioned with water, ethyl acetate, andn-butanol fractions to evaluate acetylcholinesterase (AChE) inhibitory activity and neuroprotective activity. The ethyl acetate fraction exhibited the highest values of AChE inhibitory activity (49.2% +/- 3%) and cell viability (50.7% +/- 4.8%) for neuroprotection. The structure identification of the most potential fraction (ethyl acetate fraction) revealed 15 compounds, consisting of three tannins, five flavonoids, and seven phenolics by infrared spectroscopy, nuclear magnetic resonance, and mass spectroscopy. All compounds were evaluated for their neuroprotective activity. Salidroside had the most potential neuroprotective activity. Gallic acid and methyl gallate had potential cytotoxicity in N2A cells. This study showed thatR. roseamight have potential neuroprotective activities.
C1 [Wang, Cheng-Hao; Lee, Ching-Kuo] Taipei Med Univ, Grad Inst Pharmacognosy, Taipei 11031, Taiwan.
   [Safwan, Safwan; Lee, Ching-Kuo] Taipei Med Univ, PhD Program Clin Drug Dev Herbal Med, Taipei 11031, Taiwan.
   [Safwan, Safwan] Univ Muhammadiyah Mataram, Fac Hlth Sci, Mataram 83127, Indonesia.
   [Cheng, Min-Chi; Liao, Te-Yu; Cheng, Lin-Chen; Chen, Ting-An; Lee, Ching-Kuo] Taipei Med Univ, Sch Pharm, Taipei 11031, Taiwan.
   [Kuo, Yueh-Hsiung] China Med Univ, Coll Pharm, Dept Chinese Pharmaceut Sci & Chinese Med Resourc, Taichung 40402, Taiwan.
   [Lin, Yung-Feng] Taipei Med Univ, Sch Med Lab Sci & Biotechnol, Coll Med Sci & Technol, Taipei 11031, Taiwan.
   [Lin, Yung-Feng] Taipei Med Univ, Coll Med Sci & Technol, PhD Program Med Biotechnol, Taipei 11031, Taiwan.
C3 Taipei Medical University; Taipei Medical University; Universitas
   Muhammadiyah Mataram; Taipei Medical University; China Medical
   University Taiwan; Taipei Medical University; Taipei Medical University
RP Lee, CK (corresponding author), Taipei Med Univ, Grad Inst Pharmacognosy, Taipei 11031, Taiwan.; Lee, CK (corresponding author), Taipei Med Univ, PhD Program Clin Drug Dev Herbal Med, Taipei 11031, Taiwan.; Lee, CK (corresponding author), Taipei Med Univ, Sch Pharm, Taipei 11031, Taiwan.; Lin, YF (corresponding author), Taipei Med Univ, Sch Med Lab Sci & Biotechnol, Coll Med Sci & Technol, Taipei 11031, Taiwan.; Lin, YF (corresponding author), Taipei Med Univ, Coll Med Sci & Technol, PhD Program Med Biotechnol, Taipei 11031, Taiwan.
EM tnssh31833@hotmail.com; safwan_afan@yahoo.com; d301100008@tmu.edu.tw;
   b313106079@tmu.edu.tw; b313106083@tmu.edu.tw; b313106068@tmu.edu.tw;
   kuoyh@mail.cmu.edu.tw; yflin@tmu.edu.tw; cklee@tmu.edu.tw
RI Chen, Ting-An/OTG-5036-2025; /B-8737-2011; safwan, safwan/GNP-8078-2022
OI yueh hsiung, kuo/0000-0001-5935-6755; safwan, safwan/0000-0002-8048-0301
FU Ministry of Science and Technology (Taiwan) [107-2320-B-038-019]
FX This research was funded by the Ministry of Science and Technology
   (Taiwan), grant number 107-2320-B-038-019.
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NR 52
TC 14
Z9 16
U1 1
U2 15
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JUN
PY 2020
VL 25
IS 12
AR 2801
DI 10.3390/molecules25122801
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA MM6FB
UT WOS:000550249000001
PM 32560471
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhao, MT
   Hong, XL
   Abdullah
   Yao, RL
   Xiao, Y
AF Zhao, Mingtao
   Hong, Xulin
   Abdullah
   Yao, Ruilian
   Xiao, Yi
TI Rapid biosynthesis of phenolic glycosides and their derivatives from
   biomass-derived hydroxycinnamates
SO GREEN CHEMISTRY
LA English
DT Article
ID DE-NOVO BIOSYNTHESIS; AROMATIC-ALDEHYDES; SALIDROSIDE; PATHWAY;
   HYDROXYTYROSOL; RECALCITRANCE; MONOOXYGENASE; INSIGHTS; BENZENE; ARBUTIN
AB Biomass-derived hydroxycinnamates (mainly including p-coumaric acid and ferulic acid), which are natural sources of aromatic compounds, are highly underutilized resources. There is a need to upgrade them to make them economically feasible. Value-added phenolic glycosides and their derivatives, both belonging to a class of plant aromatic natural products, are widely used in the nutraceutical, pharmaceutical, and cosmetic industries. However, their complex aromatic structures make their efficient biosynthesis a challenging process. To overcome this issue, we created three novel synthetic cascades for the biosynthesis of phenolic glycosides (gastrodin, arbutin, and salidroside) and their derivatives (hydroquinone, tyrosol, hydroxytyrosol, and homovanillyl alcohol) from p-coumaric acid and ferulic acid. Moreover, because the biomass-derived hydroxycinnamates directly provided aromatic units, the cascades enabled efficient biosynthesis. We achieved substantially high production rates (up to or above 100-fold enhancement) relative to the glucose-based biosynthesis. Given the ubiquity of the aromatic structure in natural products, the use of biomass-derived aromatics should facilitate the rapid biosynthesis of numerous aromatic natural products.
C1 [Zhao, Mingtao; Hong, Xulin; Abdullah; Yao, Ruilian; Xiao, Yi] Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, 800 Dongchuan RD Minhang Dist, Shanghai 200240, Peoples R China.
   [Yao, Ruilian; Xiao, Yi] Shanghai Jiao Tong Univ, Joint Int Res Lab Metab & Dev Sci, 800 Dongchuan RD Minhang Dist, Shanghai 200240, Peoples R China.
C3 Shanghai Jiao Tong University; Shanghai Jiao Tong University
RP Xiao, Y (corresponding author), Shanghai Jiao Tong Univ, Sch Life Sci & Biotechnol, State Key Lab Microbial Metab, 800 Dongchuan RD Minhang Dist, Shanghai 200240, Peoples R China.; Xiao, Y (corresponding author), Shanghai Jiao Tong Univ, Joint Int Res Lab Metab & Dev Sci, 800 Dongchuan RD Minhang Dist, Shanghai 200240, Peoples R China.
EM yi_xiao@sjtu.edu.cn
OI , Abdullah/0000-0003-3589-9653; Zhao, Mingtao/0000-0003-2761-673X; Xiao,
   Yi/0000-0002-5232-8513
FU National Key R&D Program of China [2019YFA0904800]; National Natural
   Science Foundation of China [31870071]; Science and Technology
   Commission of Shanghai Municipality [18JC1413600]
FX This work was sponsored by the National Key R&D Program of China
   (2019YFA0904800), the National Natural Science Foundation of China
   (31870071), and the Science and Technology Commission of Shanghai
   Municipality (18JC1413600). We thank the Instrumental Analysis Center,
   Shanghai Jiao Tong University, for help with LC-MS/MS analyses.
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NR 71
TC 28
Z9 31
U1 5
U2 103
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 1463-9262
EI 1463-9270
J9 GREEN CHEM
JI Green Chem.
PD JAN 21
PY 2021
VL 23
IS 2
BP 838
EP 847
DI 10.1039/d0gc03595e
PG 10
WC Chemistry, Multidisciplinary; Green & Sustainable Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics
GA QA5TP
UT WOS:000613508300019
DA 2026-05-27
ER

PT J
AU Hai, Z
   Wu, YB
   Ning, ZP
AF Hai, Zhen
   Wu, Yingbiao
   Ning, Zhongping
TI Salidroside attenuates atrial fibrosis and atrial fibrillation
   vulnerability induced by angiotensin-II through inhibition of
   LOXL2-TGF-β1-Smad2/3 pathway
SO HELIYON
LA English
DT Article
DE Salidroside; Atrial fibrillation; Atrial fibrosis; Angiotensin II; Lysyl
   oxidase-like 2
ID CARDIAC FIBROSIS; GROWTH-FACTOR; INJURY
AB Aims and objectives: Salidroside (SAL), an active component isolated from the Chinese plant Rose Rhodiola, has anti-inflammatory, antioxidant, anti-cancer, neuroprotective, and renal protective properties. Atrial fibrosis developed due to angiotensin II (Ang II) plays a crucial function in developing atrial fibrillation (AF). This research investigates the involvement of SAL in AF, its vulnerability to AF, and Ang II-induced inflammatory atrial fibrosis. Methods: Ang II (2 mg/kg/day) was infused underneath the skin into male C57BL/6 mice (8-10 weeks old, n = 40) for four weeks to create the AF model. SAL (50 mg/kg/day) was given intraperitoneally once per day for 28 days. Analyses of morphology, histology, and biochemical were carried out. Transesophageal burst pacing was used in vivo to induce AF. Results: Ang II injection increased mice's heart rate and systolic blood pressure (SBP), whereas SAL treatment was significantly reduced. Ang II infusion increased left atrial diameter (LAD) in mice, which was attenuated after SAL treatment. SAL alone did not affect AF inducibility, but SAL therapy markedly decreased Ang II-induced AF inducibility. Additionally, the expression levels of interleukin-1 beta (IL-1 beta), interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) were inhibited with SAL therapy in mice. Compared to the Ang II group, Ang II infusion raised malondialdehyde (MDA) levels and reduced superoxide dismutase (SOD) and catalase (CAT) activity, but SAL therapy altered all of these effects. SAL treatment significantly reduced LOXL2, TGF-beta 1, p-Smad2 and p-Smad3 protein expression than the Ang II group mice. Conclusion: SAL inhibits atrial fibrosis and potentially attenuates increased susceptibility to AF by suppressing the LOXL2-TGF-beta 1-Smad2/3 pathway.
C1 [Hai, Zhen] Shanghai Univ Tradit Chinese Med, Dept Cardiol, 1200 Cailun Rd Zhangjiang Hitech Pk,Pudong New Are, Shanghai 201203, Peoples R China.
   [Wu, Yingbiao; Ning, Zhongping] Shanghai Pudong New Area Zhoupu Hosp, Zhoupu Hosp, Dept Cardiol, Shanghai Med Coll Hlth, 1500 Zhouyuan Rd, Shanghai 201318, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Ning, ZP (corresponding author), Shanghai Pudong New Area Zhoupu Hosp, Zhoupu Hosp, Dept Cardiol, Shanghai Med Coll Hlth, 1500 Zhouyuan Rd, Shanghai 201318, Peoples R China.
EM ningzpsh@163.com
RI ; /E-9745-2017
OI Ning, Zhongping/0000-0001-5851-1223; 海, 海振/0000-0002-1854-6242; 
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NR 37
TC 20
Z9 22
U1 1
U2 12
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
EI 2405-8440
J9 HELIYON
JI Heliyon
PD NOV
PY 2023
VL 9
IS 11
AR e21220
DI 10.1016/j.heliyon.2023.e21220
EA OCT 2023
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA Z2PC7
UT WOS:001110538300001
PM 37920527
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Nugroho, A
   Choi, JS
   Hong, JP
   Park, HJ
AF Nugroho, Agung
   Choi, Jae Sue
   Hong, Joon-Pyo
   Park, Hee-Juhn
TI Anti-acetylcholinesterase activity of the aglycones of phenolic
   glycosides isolated from Leonurus japonicus
SO ASIAN PACIFIC JOURNAL OF TROPICAL BIOMEDICINE
LA English
DT Article
AB Objective: To find the genuine structure with anti-acetylcholinesterase (anti-AChE) from the phenolic glycosides abundant in Leonurus japonicus (Lamiaceae). The assay for anti-AChE activity is often used to lead anti-Alzheimer's drugs.
   Methods: The five phenolic glycosides, tiliroside, leonurusoside C, 2 '''-syringoylrutin, rutin, and lavanduliofolioside were isolated from L. japonicus. The activities of the glycosides were relatively low. Seven compounds including p-coumaric acid, caffeic acid, hydroxytyrosol, salidroside, syringic acid, kaempferol, and quercetin, which are produced by the hydrolysis of the five glycosides, were also assayed for anti-AChE activity.
   Results: Of those seven compounds, the five compounds other than salidroside and syringic acid exhibited potent anti-AChE activities. In particular, the IC(50)s of caffeic acid and quercetin were (1.05 +/- 0.19) and (3.58 +/- 0.02) mu g/mL, respectively. Rutin was the most abundant flavonoid in the extract (9.18 mg/g as measured by HPLC).
   Conclusion: The substances with potent anti-AChE were caffeic acid, quercetin, p-coumaric acid, kaempferol, and hydroxytyrosol that can be produced from their glycosides.
C1 [Nugroho, Agung] Lambung Mangkurat Univ, Dept Agroind Technol, Fac Agr, Banjarbaru 70714, Indonesia.
   [Choi, Jae Sue] Pukyong Natl Univ, Dept Food Sci & Nutr, Busan 48513, South Korea.
   [Hong, Joon-Pyo; Park, Hee-Juhn] Sangji Univ, Dept Pharmaceut Engn, Wonju 26339, South Korea.
C3 Universitas Lambung Mangkurat; Pukyong National University; Sangji
   University
RP Park, HJ (corresponding author), Sangji Univ, Dept Pharmaceut Engn, Wonju 26339, South Korea.
EM hjpark@sangji.ac.kr
RI Nugroho, Agung/Z-1150-2019
OI Nugroho, Agung/0000-0002-7236-9654
FU Sangji University Research Fund [2016-0101]
FX This research was supported by the Sangji University Research Fund
   (Grant No. 2016-0101).
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NR 26
TC 19
Z9 23
U1 0
U2 11
PU WOLTERS KLUWER MEDKNOW PUBLICATIONS
PI MUMBAI
PA WOLTERS KLUWER INDIA PVT LTD , A-202, 2ND FLR, QUBE, C T S  NO 1498A-2
   VILLAGE MAROL, ANDHERI EAST, MUMBAI, 400059, INDIA
SN 2221-1691
EI 2588-9222
J9 ASIAN PAC J TROP BIO
JI Asian Pac. Trop. Biomed.
PD OCT
PY 2017
VL 7
IS 10
BP 849
EP 854
DI 10.1016/j.apjtb.2017.08.013
PG 6
WC Tropical Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Tropical Medicine
GA FK8FP
UT WOS:000413743600001
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yu, H
   Xu, H
   Yang, XY
   Zhang, ZW
   Hu, JC
   Fu, J
   Lu, JY
   Bu, MM
   Zhang, HJ
   Zhai, Z
   Wang, JY
   Jiang, JD
   Wang, Y
AF Yu, Hang
   Xu, Hui
   Yang, Xinyu
   Zhang, Zhengwei
   Hu, Jiachun
   Fu, Jie
   Lu, Jinyue
   Bu, Mengmeng
   Zhang, Haojian
   Zhai, Zhao
   Wang, Jingyue
   Jiang, Jiandong
   Wang, Yan
TI Gut microbiota-based pharmacokinetic-pharmacodynamic study and molecular
   mechanism of specnuezhenide in the treatment of colorectal cancer
   targeting carboxylesterase
SO JOURNAL OF PHARMACEUTICAL ANALYSIS
LA English
DT Article
DE Specnuezhenide; Pharmacokinetics; Tumor; Gut microbiota; Fungi;
   Metabolism
ID LIGUSTRI-LUCIDI-FRUCTUS; METABOLITES; LIVER; CELL; EFFICACY; PATHWAY;
   FUNGI; AXIS
AB Specnuezhenide (SNZ) is among the main components of Fructus Ligustri Lucidi, which has antiinflammation, anti-oxidation, and anti-tumor effect. The low bioavailability makes it difficult to explain the mechanism of pharmacological effect of SNZ. In this study, the role of the gut microbiota in the metabolism and pharmacokinetics characteristics of SNZ as well as the pharmacological meaning were explored. SNZ can be rapidly metabolized by the gut microbiome, and two intestinal bacterial metabolites of SNZ, salidroside and tyrosol, were discovered. In addition, carboxylesterase may be the main intestinal bacterial enzyme that mediates its metabolism. At the same time, no metabolism was found in the incubation system of SNZ with liver microsomes or liver homogenate, indicating that the gut microbiota is the main part involved in the metabolism of SNZ. In addition, pharmacokinetic studies showed that salidroside and tyrosol can be detected in plasma in the presence of gut microbiota. Interestingly, tumor development was inhibited in a colorectal tumor mice model administered orally with SNZ, which indicated that SNZ exhibited potential to inhibit tumor growth, and tissue distribution studies showed that salidroside and tyrosol could be distributed in tumor tissues. At the same time, SNZ modulated the structure of gut microbiota and fungal group, which may be the mechanism governing the antitumoral activity of SNZ. Furthermore, SNZ stimulates the secretion of short-chain fatty acids by intestinal flora in vitro and in vivo. In the future, targeting gut microbes and the interaction between natural products and gut microbes could lead to the discovery and development of new drugs. (c) 2023 The Authors. Published by Elsevier B.V. on behalf of Xi'an Jiaotong University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Yu, Hang; Xu, Hui; Yang, Xinyu; Zhang, Zhengwei; Bu, Mengmeng; Zhang, Haojian; Zhai, Zhao; Wang, Jingyue; Jiang, Jiandong; Wang, Yan] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.
C3 Chinese Academy of Medical Sciences - Peking Union Medical College;
   Peking Union Medical College
RP Jiang, JD; Wang, Y (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China.
EM jiang.jdong@163.com; wangyan@imm.ac.cn
RI zhang, haojian/HHZ-7092-2022; Yu, Hang/GQQ-6321-2022; Zhang,
   Zhengwei/JCN-7230-2023; Lu, Jinyue/OTN-0537-2025
OI Hu, Jia-Chun/0009-0006-1825-3438; Yu, Hang/0000-0001-7419-3202; 
FU National Key R&D Program of China [2022YFA0806400]; CAMS Innovation Fund
   for Medical Sciences; National Natural Science Foundation of China
   [2022-I2M-1-028, 2022-I2M-2-002]; Beijing Key Laboratory of Non-Clinical
   Drug Metabolism and PK/PD study, China [2021-I2M-1-007];  [81973290]; 
   [82173888];  [Z141102004414062]
FX This project was supported by the National Key R&D Program of China
   (Grant No.: 2022YFA0806400), the CAMS Innovation Fund for Medical
   Sciences (Grant Nos.: 2022-I2M-1-028, 2022-I2M-2-002, and
   2021-I2M-1-007), the National Natural Science Foundation of China (Grant
   Nos.: 81973290 and 82173888), and Beijing Key Laboratory of Non-Clinical
   Drug Metabolism and PK/PD study, China (Grant No.: Z141102004414062). We
   would like to thank Shimadzu (China) Co., Ltd. for technological
   support.
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NR 71
TC 23
Z9 26
U1 3
U2 32
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2095-1779
EI 2214-0883
J9 J PHARM ANAL
JI J. Pharm. Anal.
PD SEP
PY 2023
VL 13
IS 9
BP 1024
EP 1040
DI 10.1016/j.jpha.2023.06.012
EA OCT 2023
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA U8LB7
UT WOS:001087250500001
PM 37842660
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, DH
   Lu, D
   Liu, HX
   Xue, EX
   Zhang, Y
   Shang, P
   Pan, XY
AF Chen, Deheng
   Lu, Di
   Liu, Haixiao
   Xue, Enxing
   Zhang, Yu
   Shang, Ping
   Pan, Xiaoyun
TI Pharmacological blockade of PCAF ameliorates osteoarthritis development
   via dual inhibition of TNF-α-driven inflammation and ER stress
SO EBIOMEDICINE
LA English
DT Article
DE PCAF; Salidroside; Osteoarthritis; NF-kappa B; ER stress
ID NF-KAPPA-B; HISTONE ACETYLTRANSFERASE PCAF; ENDOPLASMIC-RETICULUM
   STRESS; GENE-EXPRESSION; MATRIX METALLOPROTEINASES; CHONDROCYTES;
   APOPTOSIS; SALIDROSIDE; MODEL; TRANSCRIPTION
AB Background: Epigenetic mechanisms have been reported to play key roles in osteoarthritis (OA) development. P300/CBP-associated factor (PCAF) is a member of the histone acetyltransferases, which exhibits a strong relationship with endoplasmic reticulum (ER) stress and transcription factor nuclear factor kappa B (NF-kappa B) signals. Salidroside, a natural histone acetylation inhibitor, showed its anti-inflammatory and anti-apoptotic effects in lipopolysaccharide (LPS)-stimulated microglia cells in our previous study. However, whether Sal has a protective effect against OA remains unknown, and its relationships to PCAF, NF-kappa B, and the ER stress pathway should be explored further.
   Methods: We identified the role of PCAF in the pathogenesis of OA and determined the chondroprotective effect of Sal on both tumor necrosis factor alpha (TNF-alpha)-treated human chondrocytes and a destabilized medial meniscus (DMM) mouse OA model.
   Findings: We found increased PCAF expression in human OA cartilage and TNF-alpha-driven chondrocytes. Meanwhile, silencing of PCAF attenuated nuclear p65 and C/EBP homologous protein levels in chondrocytes upon TNF-astimulation. Furthermore, Sal was found to specifically bind to the inhibitory site of the PCAF protein structure, which subsequently reversed the TNF-alpha-induced activation of NF-kappa B signal and ER stress-related apoptosis in chondrocytes. In addition, the protective effect of Sal and its inhibitory effects on PCAF as well as inflammatory- and ER stress-related markers were also observed in the mouse DMM model.
   Interpretation: Pharmacological blockade of PCAF by Sal ameliorates OA development via inhibition of inflammation and ER stress, which makes Sal a promising therapeutic agents for the treatment of OA. (C) 2019 The Author(s). Published by Elsevier B.V.
C1 [Chen, Deheng; Lu, Di; Liu, Haixiao; Xue, Enxing; Zhang, Yu; Pan, Xiaoyun] Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
   [Chen, Deheng; Lu, Di; Liu, Haixiao; Xue, Enxing; Zhang, Yu; Shang, Ping; Pan, Xiaoyun] Wenzhou Med Univ, Yuying Childrens Hosp, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
   [Chen, Deheng; Lu, Di; Liu, Haixiao; Xue, Enxing; Zhang, Yu; Pan, Xiaoyun] Bone Res Inst, Key Orthopaed Lab Zhejiang Prov, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
   [Shang, Ping] Wenzhou Med Univ, Affiliated Hosp 2, Dept Rehabil, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University
RP Pan, XY (corresponding author), Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.; Shang, P; Pan, XY (corresponding author), Wenzhou Med Univ, Yuying Childrens Hosp, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.; Shang, P (corresponding author), Wenzhou Med Univ, Affiliated Hosp 2, Dept Rehabil, 109 Xueyuanxi Rd, Wenzhou 325027, Zhejiang, Peoples R China.
EM 260809686@qq.com; Xiaoyunpan@126.com
FU National Natural Science Foundation of China [81601983, 81501869];
   Zhejiang Medical and Health Project [2018238589]; Wenzhou Science and
   Technology Foundation [Y20170393, Y20190023]; Second Affiliated Hospital
   of Wenzhou Medical University
FX Financial supports from National Natural Science Foundation of China
   (Nos. 81601983 and 81501869); Zhejiang Medical and Health Project (No.
   2018238589), Wenzhou Science and Technology Foundation (Y20170393 and
   Y20190023), the Yuying and Yumiao Project of The Second Affiliated
   Hospital of Wenzhou Medical University are well acknowledged.
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NR 61
TC 33
Z9 37
U1 0
U2 21
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2352-3964
J9 EBIOMEDICINE
JI EBioMedicine
PD DEC
PY 2019
VL 50
BP 395
EP 407
DI 10.1016/j.ebiom.2019.10.054
PG 13
WC Medicine, General & Internal; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine; Research & Experimental Medicine
GA JW7KG
UT WOS:000503226300041
PM 31735552
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, YZ
   Tang, HL
   Liu, XX
   Chen, HL
   Feng, N
   Zhang, J
   Wang, CL
   Qiu, M
   Yang, J
   Zhou, XY
AF Liu, Yanzhuo
   Tang, Honglin
   Liu, Xiaoxiao
   Chen, Honglei
   Feng, Na
   Zhang, Jing
   Wang, Chenlong
   Qiu, Miao
   Yang, Jing
   Zhou, Xiaoyang
TI Frontline Science: Reprogramming COX-2, 5-LOX, and CYP4A-mediated
   arachidonic acid metabolism in macrophages by salidroside alleviates
   gouty arthritis
SO JOURNAL OF LEUKOCYTE BIOLOGY
LA English
DT Article
DE arachidonic acid; gouty inflammation; macrophage; metabolism;
   salidroside
ID KAPPA-B; NLRP3 INFLAMMASOME; MURINE MODEL; OXIDATIVE STRESS;
   RHODIOLA-ROSEA; ANIMAL-MODEL; IN-VIVO; ACTIVATION; INHIBITOR; PATHWAY
AB Cyclooxygenase-2 (COX-2), 5-lipoxygenase (5-LOX), and cytochrome P450 (CYP) 4A-mediated arachidonic acid (AA) metabolism play an essential role in human inflammatory disorders. Blocking COX-2 pathway would shunt AA metabolism to the other pathway, thereby decreasing the efficacy and exacerbating adverse effects. Here we demonstrated that reprogramming COX-2, 5-LOX, and CYP4A-mediated AA metabolism in macrophages by salidroside (Sal) ameliorates monosodium urate (MSU) crystal-induced inflammation. Compared with COX-2 inhibitor celecoxib, Sal (80 mg/kg) presented a superior anti-arthritic profile in MSU crystal-treated rats, accompanied with the decreased expression of COX-2, 5-LOX, and CYP4A and production of prostaglandin E2 (PGE(2)), leukotriene B4 (LTB4), and 20-hydroxyeicosatetraenoic acid (20-HETE) in the synovial fluid macrophages. Sal decreased representative M1 marker (iNOS and CD86, etc.) expression and M1 cytokine (TNF-alpha and IL-1 beta) production, whereas it increased M2 marker (CD206 and Arg-1) expression and M2 cytokine (TGF-beta and IL-10) production. The injection of conditioned medium from MSU crystal-treated macrophages into the ankle joint of rats reproduced the gouty inflammation, which was attenuated by Sal. Mechanistically, down-regulation of COX-2, 5-LOX, and CYP4A in the RAW264.7 and NR8383 macrophages by Sal skewed macrophage polarization away from the M1 phenotype, and thereby prevented neutrophil migration and chondrocyte degradation with STAT1 and NF-kappa B inactivation. Conversely, overexpression of COX-2, 5-LOX, CYP4A or STAT1, or exogenous addition of IL-1 beta or TNF-alpha partially abolished these effects. Together, inhibition of COX-2, 5-LOX, and CYP4A in macrophages by Sal ameliorates MSU crystal-induced inflammation through decreasing TNF-alpha and IL-1 beta production, and may serve as a novel therapeutic strategy.
C1 [Liu, Yanzhuo; Tang, Honglin; Zhou, Xiaoyang] Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan 430060, Hubei, Peoples R China.
   [Liu, Xiaoxiao; Wang, Chenlong; Qiu, Miao; Yang, Jing] Wuhan Univ, Sch Basic Med Sci, Dept Pharmacol, Wuhan, Hubei, Peoples R China.
   [Chen, Honglei] Wuhan Univ, Sch Basic Med Sci, Dept Pathol & Pathophysiol, Wuhan, Hubei, Peoples R China.
   [Feng, Na] Hubei Univ Med, Dept Anat, Shiyan, Peoples R China.
   [Zhang, Jing] Wuhan Univ, Anim Expt Ctr, Wuhan, Hubei, Peoples R China.
   [Qiu, Miao] South Cent Univ Nationalities, Hubei Key Lab Med Informat Anal & Tumor Diag & Tr, Wuhan, Hubei, Peoples R China.
C3 Wuhan University; Wuhan University; Wuhan University; Hubei University
   of Medicine; Wuhan University; South Central Minzu University
RP Zhou, XY (corresponding author), Wuhan Univ, Renmin Hosp, Dept Cardiol, Wuhan 430060, Hubei, Peoples R China.
EM xiaoyangzh@whu.edu.cn
RI ; Chen, Honglei/ABG-8632-2021; Zhou, Xiaoyang/HHM-7041-2022; Liu,
   Yanzhuo/AAA-3305-2019
OI yang, jing/0000-0003-2733-8629; , Xiaoyang/0000-0002-3203-6855
FU National Natural Science Foundation of China [81370337, 81173089]; Hubei
   Key Laboratory of Medical Information Analysis & Tumor Diagnosis and
   Treatment [PJS140011707]
FX This work was partially supported by the National Natural Science
   Foundation of China (Grant 81370337 [to X.Z.] and 81173089 [Y.J.]), and
   Hubei Key Laboratory of Medical Information Analysis & Tumor Diagnosis
   and Treatment (PJS140011707) (to Y.L.).
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NR 59
TC 66
Z9 75
U1 2
U2 74
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0741-5400
EI 1938-3673
J9 J LEUKOCYTE BIOL
JI J. Leukoc. Biol.
PD JAN
PY 2019
VL 105
IS 1
BP 11
EP 24
DI 10.1002/JLB.3HI0518-193R
PG 14
WC Cell Biology; Hematology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Hematology; Immunology
GA HF7HE
UT WOS:000454409400002
PM 30265377
OA Bronze
DA 2026-05-27
ER

PT J
AU Molina, CN
   Gasparre, N
   Vinuesa, JM
   Scanlon, MG
AF Molina, Carla N.
   Gasparre, Nicola
   Vinuesa, Jordi Manes
   Scanlon, Martin G.
TI Chemical profiling and processing effects on bioactive compounds in
   Rhodiola rosea and Eleutherococcus senticosus
SO INTERNATIONAL JOURNAL OF FOOD SCIENCE AND TECHNOLOGY
LA English
DT Article
DE degradation; extraction/separation; health foods; processing effects;
   solubility
ID ELEUTHEROSIDE-E; EXTRACTION; INFUSION; HERBS; L.
AB Rhodiola rosea and Eleutherococcus senticosus are widely studied adaptogens, often consumed as herbal tea or supplements. However, further insights into their roots are needed to expand their applications. The aim of this study was to examine their proximate composition and the impact of processing conditions (pH and temperature) on their bioactive compounds. The results revealed that both roots are abundant sources of fibre, particularly E. senticosus (70.89 to 77.96 g/100 g). Moreover, rosavin and salidroside were highest in samples R3-R5, with concentrations ranging from 55 to 68 and 25 to 69 mg/g root, respectively. As for E. senticosus, eleutheroside E showed similar contents within samples (10-15 mg/g root). Optimal extraction occurred at pH 3-5 and 50 degrees C, except for rosavin and salidroside. The stability of most bioactive compounds under acidic and high-temperature conditions suggests that dried R. rosea and E. senticosus roots have potential for functional food development.
C1 [Molina, Carla N.; Vinuesa, Jordi Manes; Scanlon, Martin G.] Univ Valencia, Fac Pharm, Dept Publ Hlth, Burjassot, Spain.
   [Molina, Carla N.; Gasparre, Nicola; Scanlon, Martin G.] Univ Manitoba, Dept Food & Human Nutr Sci, Winnipeg, MB R3T 2N2, Canada.
C3 University of Valencia; University of Manitoba
RP Scanlon, MG (corresponding author), Univ Valencia, Fac Pharm, Dept Publ Hlth, Burjassot, Spain.
EM molinac@myumanitoba.ca; nicola.gasparre@umanitoba.ca;
   scanlon@cc.umanitoba.ca; scanlon@cc.umanitoba.ca
RI Scanlon, Martin/LKL-9024-2024; Gasparre, Nicola/GPS-4429-2022
OI Molina, Carla N/0000-0001-6813-3086; Gasparre,
   Nicola/0000-0001-5687-0249
FU NSERC Discovery Research Program [RGPIN-2024-05467]
FX Authors acknowledge the financial support of NSERC Discovery Research
   Program (RGPIN-2024-05467).
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NR 31
TC 3
Z9 3
U1 7
U2 13
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0950-5423
EI 1365-2621
J9 INT J FOOD SCI TECH
JI Int. J. Food Sci. Technol.
PD JAN
PY 2025
VL 60
IS 1
AR vvaf049
DI 10.1093/ijfood/vvaf049
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA 2IB5B
UT WOS:001483163400001
OA gold
DA 2026-05-27
ER

PT J
AU Jiang, YP
   Liu, BG
   Dang, Y
   Liu, LJ
   Pang, Y
   Bai, XD
   Sun, F
   Kang, TH
   Zhao, ZH
AF Jiang, Ya Ping
   Liu, Bao Gui
   Dang, Yi
   Liu, Lin Jie
   Pang, Yang
   Bai, Xiao Dong
   Sun, Feng
   Kang, Tian Hong
   Zhao, Zheng Hang
TI Integrative analysis of transcriptomics and metabolomics reveals the
   protective effect and mechanism of salidroside on testicular
   ischemia-reperfusion injury
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; protective effects; ischemia-reperfusion injury;
   ferroptosis; Nfr2/HO-1/GPX4 signaling pathway
ID OXIDATIVE STRESS; FERROPTOSIS; TORSION; PATHWAY; DAMAGE; NRF2
AB Testicular torsion is a critical urologic condition for which testicular detorsion surgery is considered irreplaceable as well as the golden method of reversal. However, the surgical treatment is equivalent to a blood reperfusion process, and no specific drugs are available to treat blood reperfusion injuries. Salidroside (SAL) is one of the main effective substances in rhodiola, which has been shown to have antioxidant and antiapoptosis activities. This study was designed to determine whether SAL exerted a protective effect on testicular ischemia-reperfusion (I/R) injury. In this study, the I/R injury model of the testes and reoxygenation (OGD/R) model were used for verification, and SAL was administered at doses of 100 mg/kg and 0.05 mmol/L, respectively. After the experiments, the testicular tissue and TM4 Sertoli cells were collected for histopathologic and biochemical analyses. The results revealed that SAL improves the structure of testicular tissue and regulates the oxidation-antioxidation system. To further understand the molecular mechanisms of SAL in treating testicular I/R injuries, transcriptomics and metabonomics analyses were integrated. The results show that the Nfr2/HO-1/GPX4/ferroptosis signaling pathway is enriched significantly, indicating that it may be the main regulatory pathway for SAL in the treatment of testicular I/R injuries. Thereafter, transfection with Nrf2 plasmid-liposome was used to reverse verify that the Nfr2/HO-1/GPX4/ferroptosis signaling pathway was the main pathway for SAL anti-testicular I/R injury treatment. Thus, it is suggested that SAL can protect against testicular I/R injuries by regulating the Nfr2/HO-1/GPX4 signaling pathway to inhibit ferroptosis and that SAL may be a potential drug for the treatment of testicular I/R injuries.
C1 [Jiang, Ya Ping; Zhao, Zheng Hang] Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Pharmacol, Hlth Sci Ctr, Xian, Shaanxi, Peoples R China.
   [Jiang, Ya Ping; Liu, Bao Gui; Liu, Lin Jie; Pang, Yang; Kang, Tian Hong] Yanan Univ, Xianyang Hosp, Dept Pharm, Yanan, Shaanxi, Peoples R China.
   [Dang, Yi; Bai, Xiao Dong] Yanan Univ, Xianyang Hosp, Dept Clin Res, Yanan, Shaanxi, Peoples R China.
   [Sun, Feng] Yanan Univ, Xianyang Hosp, Dept Sci & Educ, Yanan, Shaanxi, Peoples R China.
C3 Xi'an Jiaotong University; Yanan University; Yanan University; Yanan
   University
RP Zhao, ZH (corresponding author), Xi An Jiao Tong Univ, Sch Basic Med Sci, Dept Pharmacol, Hlth Sci Ctr, Xian, Shaanxi, Peoples R China.
EM zzh@mail.xjtu.edu.cn
RI liu, baogui/GRJ-8843-2022
FU Key research and development projects of Xianyang City, Shaanxi Province
   [L2022ZDYFSF077]; Yan'an University Xianyang Hospital postgraduate
   research innovation program fund [2023YK006]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This work was
   supported by the key research and development projects of Xianyang City,
   Shaanxi Province (L2022ZDYFSF077) and Yan'an University Xianyang
   Hospital postgraduate research innovation program fund (2023YK006).
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NR 54
TC 5
Z9 6
U1 2
U2 29
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAY 16
PY 2024
VL 15
AR 1377836
DI 10.3389/fphar.2024.1377836
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SK4Q8
UT WOS:001234338200001
PM 38818379
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Meng, JL
   Li, YF
   Sun, FY
   Feng, WT
   Ye, H
   Tian, TN
   Lei, M
AF Meng, Jialei
   Li, Yunfeng
   Sun, Fangyuan
   Feng, Wentao
   Ye, Hui
   Tian, Tianning
   Lei, Ming
TI Salidroside alleviates LPS-induced liver injury and inflammation through
   SIRT1-NF-κB pathway and NLRP3 inflammasome
SO IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
LA English
DT Article
DE Anti-inflammation; Lipopolysaccharide; Liver injury; Nuclear factor
   Kappa B; Salidroside
ID ACUTE LUNG INJURY; KAPPA-B; ACTIVATION; PROTECTS; CELLS
AB Objective(s): Salidroside (SAL), an active ingredient purified from the medicinal plant Rhodiola rosea, has anti-inflammatory, anti-oxidant, anticancer, and neuroprotective properties. The study aims to examine SAL's protective role in liver damage brought on by lipopolysaccharide (LPS). Materials and Methods: Six to eight-week-old male C57BL/6 wild-type mice were intraperitoneally treated with 10 mg/kg LPS for 24 hr and 50 mg/kg SAL two hours before LPS administration. Mice were categorized into control, LPS, and LPS + SAL groups. To evaluate liver injury, biochemical and TUNNEL staining test studies were performed. The Elisa assay analyzed interleukin- 1 beta (IL-1 beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin-6 (IL-6) pro-inflammatory cytokine expression levels. RT-qPCR and western blotting measured mRNA and protein expression of SIRT1, NF-kB, NLRP3, cleaved caspase-1, and GSDMD, respectively. Results: Analysis of the serum alanine/aspartate aminotransferases (ALT/AST), malondialdehyde (MDA), superoxide dismutase (SOD), and catalase (CAT) revealed that SAL protected against hepatotoxicity induced by LPS. The pathological evaluation of the liver supported the protection provided by SAL. SAL treatment reversed IL-1 beta, TNF-alpha, and IL-6 pro-inflammatory cytokines after being induced by LPS (all, P<0.001). The western blotting examination results demonstrated that SAL increased the levels of Sirtuin 1 (SIRT1) expression but markedly reduced the phosphorylation of Nuclear Factor Kappa B (NF-B) and the expressions of NLRP3, cleaved caspase-1, and gasdermin D (GSDMD) induced by LPS (all, P<0.001). Conclusion: Our results speculated that by inhibiting the SIRT1- NF-kappa B pathway and NLRP3 inflammasome, SAL defends against LPS-induced liver injury and inflammation.
C1 [Meng, Jialei; Li, Yunfeng; Sun, Fangyuan; Feng, Wentao; Ye, Hui; Tian, Tianning; Lei, Ming] Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Trauma Emergency Ctr, 358 Datong Rd, Shanghai 200137, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Lei, M (corresponding author), Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Trauma Emergency Ctr, 358 Datong Rd, Shanghai 200137, Peoples R China.
EM leimsh@163.com
FU National Natural Science Foundation of China [81973649, 82174189]; Open
   Fund of the Key Laboratory of Emergency and Trauma Research of the
   Ministry of Education (Hainan Medical University) [Gant.KLET-202115];
   Construction of Shanghai Municipal Health Commission East China Area and
   Municipal Traditional Chinese Medicine Specialized Disease Alliance
   [(2021-2023) -0302]; Key Sub College of Shanghai Pudong New Area Health
   Commission [PWZy2020-07]; Shanghai Pudong New Area Health Commission
   Joint Public Relations Project [PW2021D-05]; Medical Discipline
   Construction in Pudong New Area, Shanghai [PWYgy2021-06]; Pudong New
   Area National Comprehensive Reform Pilot Zone for Traditional Chinese
   Medicine Development Project [PDZY-2022-0701]
FX This study was supported by 1) The National Natural Science Foundation
   of China (No. 81973649, 82174189) . 2) Open Fund of the Key Laboratory
   of Emergency and Trauma Research of the Ministry of Education (Hainan
   Medical University) (Gant.KLET-202115) . 3) Construction of Shanghai
   Municipal Health Commission East China Area and Municipal Traditional
   Chinese Medicine Specialized Disease Alliance (ZY (2021-2023) -0302) .
   4) Key Sub College of Shanghai Pudong New Area Health Commission
   (PWZy2020-07) . 5) Shanghai Pudong New Area Health Commission Joint
   Public Relations Project (PW2021D-05) . 6) Medical Discipline
   Construction in Pudong New Area, Shanghai (PWYgy2021-06) . 7) Pudong New
   Area National Comprehensive Reform Pilot Zone for Traditional Chinese
   Medicine Development Project (PDZY-2022-0701) .
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NR 32
TC 11
Z9 15
U1 4
U2 17
PU MASHHAD UNIV MED SCIENCES
PI MASHHAD
PA VICE-CHANCELLOR FOR RES CTR OFF IJBMS, DANESHGAH ST, PO BOX 9138813944 -
   445, MASHHAD, 00000, IRAN
SN 2008-3866
EI 2008-3874
J9 IRAN J BASIC MED SCI
JI Iran. J. Basic Med. Sci.
PD MAR
PY 2024
VL 27
IS 3
BP 297
EP 303
DI 10.22038/IJBMS.2023.69401.15124
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IH2F6
UT WOS:001165364900015
PM 38333759
DA 2026-05-27
ER

PT J
AU Li, H
   Chen, C
AF Li, Hai
   Chen, Chen
TI Inhibition of autophagy enhances synergistic effects of Salidroside and
   anti-tumor agents against colorectal cancer
SO BMC COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
DE Salidroside; Autophagy; AMPK signaling; Anti-tumor agents; Colorectal
   cancer
ID IN-VITRO; CELLS; JAK2/STAT3; APOPTOSIS; GROWTH
AB Background: Various plant extracts have been suggested to be used as auxiliary agents in chemotherapy considering their anti-proliferative effect on cancer cells. However, recent reports reveal that plant extracts may function as inducers of autophagy of cancer cells. In general, autophagy confers survival advantage for cells responding to stress conditions, thus representing an important mechanism for chemo-resistance. This study was aimed to investigate the effectiveness of combined use of Salidroside (Sal, a phenylpropanoid glycosides from Rhodiola rosea L) with anti-tumor agents against colorectal cancer (CRC) cells, and moreover to evaluate the potential role of autophagy in the combined therapy.
   Methods: CRC cells, HCT-116, were incubated with Sal alone or in combination with conventional chemotherapy agents including oxaliplatin (OXA), 5-fluorouracil (5-FU) and Doxorubicin (ADM). Cell proliferative characteristics were evaluated by cell viability and apoptosis rate. The protein expression was assessed by Immunofluorescent and Western blot assays.
   Results: Sal, alone or in combination with anti-tumor agents, increased expression of autophagic biomarkers, including LC3B and Becline-1, suggesting an autophagy induction. Except for the up-regulation of p-AMPK, p-mTOR, p-NF-kappa B (p65), TGF-beta, p-JAK2 and p-STAT3 were down-regulated by Sal. Because autophagy is positively correlated with the activation of AMPK/mTOR, NF-kappa B, TGF beta 1 and JAK2/STAT3 cascades, the autophagy induced by Sal may associate with AMPK activation. Indeed, blockage of AMPK signaling via Compound C or AMPK knockdown inhibited the autophagy. The blockage of AMPK signaling or a direct inhibition of autophagy via 3-MA increased effectiveness of combined use of Sal with anti-tumor agents against CRC.
   Conclusions: Inhibition of autophagy enhances synergistic effects of Sal and anti-tumor agents against colorectal cancer. This study provides experimental evidence and theoretical reference for improvement of a novel chemotherapy treatment protocol.
C1 [Li, Hai] Huazhong Univ Sci & Technol, Tongji Hosp, Dept Geriatr, Tongji Med Coll, Wuhan, Hubei, Peoples R China.
   [Chen, Chen] Huazhong Univ Sci & Technol, Tongji Med Coll, Dept Breast & Thyroid Surg, Union Hosp, Wuhan, Hubei, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Li, H (corresponding author), Huazhong Univ Sci & Technol, Tongji Hosp, Dept Geriatr, Tongji Med Coll, Wuhan, Hubei, Peoples R China.
EM lihaiges@hust.edu.cn
RI Chen, Chen/GMX-0991-2022
OI Li, Hai/0000-0001-7937-5902
FU Shenzhen Municipal Commission of science and technology innovation
   [JCYJ20150402152005631]
FX This study was supported by the Shenzhen Municipal Commission of science
   and technology innovation (Grant No. JCYJ20150402152005631).
CR Bastola T, 2017, MOLECULES, V22, DOI 10.3390/molecules22020242
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NR 23
TC 44
Z9 55
U1 0
U2 21
PU BIOMED CENTRAL LTD
PI LONDON
PA 236 GRAYS INN RD, FLOOR 6, LONDON WC1X 8HL, ENGLAND
SN 1472-6882
J9 BMC COMPLEM ALTERN M
JI BMC Complement. Altern. Med.
PD DEC 16
PY 2017
VL 17
AR 538
DI 10.1186/s12906-017-2046-z
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA FQ0XD
UT WOS:000418079400002
PM 29246220
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, XH
   Qian, J
   Meng, Y
   Wang, P
   Cheng, RZ
   Zhou, GX
   Zhu, SX
   Liu, C
AF Wang, Xiaohong
   Qian, Jing
   Meng, Yun
   Wang, Ping
   Cheng, Ruizhi
   Zhou, Guoxiong
   Zhu, Shunxing
   Liu, Chun
TI Salidroside alleviates severe acute pancreatitis-triggered pancreatic
   injury and inflammation by regulating miR-217-5p/YAF2 axis
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Salidroside; Severe acute pancreatitis; Inflammation; miR-217-5p; YAF2
ID LUNG-CANCER CELLS; INDUCED BRAIN-INJURY; BIOMARKERS; YAF2; METASTASIS;
   APOPTOSIS; MIR-216A; SURVIVAL; PATHWAY; MIRNAS
AB Background: Our previous studies have shown that salidroside (Sal) exerted a protective effect in severe acute pancreatitis (SAP) via inhibiting the inflammatory response. However, the molecular mechanism has not been fully elucidated.
   Methods: Using SAP rat model and miRNA microarray, the effect of Sal on miRNA expression profiling was determined and then validated their changes by quantitative Real-time PCR (qRT-PCR). Then, SAP cell model, enzyme-linked immunosorbent assay (ELISA) and Cell Counting Kit-8 (CCK-8) assay were used to explore the biological function of miR-217-5p in vitro. Bioinformatics analysis, luciferase reporter assay and miRNA pull-down assay were performed to investigate the underlying mechanism of miR-217-5p in the protection of Sal against SAP.
   Results: Compared with SAP group, 21 differentially expressed miRNAs were identified in SAP + Sal group. The target genes of these miRNAs were strongly associated with regulation of transcription, Axon guidance, Pathways in cancer and MAPK signaling pathway. Among these miRNAs, miR-217-5p was the most downregulated miRNA. Sal treatment alleviated cell injury and reduced the production of pro-inflammatory cytokines. Whereas overexpression of miR-217-5p reversed the effects of Sal. We identified YY1 associated factor 2 (YAF2) as a direct target gene of miR-217-5p and Sal treatment could upregulate YAF2 expression via targeting miR-217-5p. Furthermore, knockdown of YAF2 counteracted Sal-induced alleviation of cell injury and inflammation. Moreover, Sal could suppress the activation of p38 MAPK pathway by regulating miR-217-5p/YAF2 axis.
   Conclusions: Our findings for the first time highlighted that Sal alleviated pancreatic injury and inhibited inflammation by regulating miR-217-5p/YAF2 axis, which might provide new therapeutic strategies for SAP treatment.
C1 [Wang, Xiaohong; Meng, Yun; Wang, Ping; Cheng, Ruizhi] Yizheng Hosp Nanjing Drum Tower Hosp Grp, Dept Gastroenterol, Yizheng 211900, Jiangsu, Peoples R China.
   [Qian, Jing] Yizheng Hosp Nanjing Drum Tower Hosp Grp, Dept Gen Surg, Yizheng 211900, Jiangsu, Peoples R China.
   [Zhou, Guoxiong] Nantong Univ, Dept Gastroenterol, Affiliated Hosp, Nantong 226001, Jiangsu, Peoples R China.
   [Zhu, Shunxing; Liu, Chun] Nantong Univ, Lab Anim Ctr, Nantong 226001, Jiangsu, Peoples R China.
C3 Nanjing University; Nanjing University; Nantong University; Nantong
   University
RP Wang, XH (corresponding author), Yizheng Hosp Nanjing Drum Tower Hosp Grp, Dept Gastroenterol, Yizheng 211900, Jiangsu, Peoples R China.
EM wx102474wx@163.com
RI Wang, Xiaohong/JXL-8370-2024
FU Traditional Chinese Medicine Technology Development Plan Project of
   Jiangsu Province in 2020: Basic and Clinical Study on Salidroside in the
   Adjuvant Treatment of Severe Acute Pancreatitis [YB2020088]; Health
   Innovation Project of Lvyang Jinfeng Plan of Yangzhou City in 2020:
   Basic and Clinical Study on Salidroside in the Adjuvant Treatment of
   Severe Acute Pancreatitis [LJ202037]
FX This work was supported by the Traditional Chinese Medicine Technology
   Development Plan Project of Jiangsu Province in 2020: Basic and Clinical
   Study on Salidroside in the Adjuvant Treatment of Severe Acute
   Pancreatitis (No. YB2020088) and the Health Innovation Project of Lvyang
   Jinfeng Plan of Yangzhou City in 2020: Basic and Clinical Study on
   Salidroside in the Adjuvant Treatment of Severe Acute Pancreatitis (No.
   LJ202037).
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NR 50
TC 17
Z9 19
U1 3
U2 30
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD OCT
PY 2022
VL 111
AR 109123
DI 10.1016/j.intimp.2022.109123
EA AUG 2022
PG 11
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA 6O5EI
UT WOS:000890264000003
PM 35963157
DA 2026-05-27
ER

PT J
AU Zeng, LJ
   Zhou, C
   Xu, WQ
   Huang, YP
   Wang, WC
   Ma, ZQ
   Huang, J
   Li, J
   Hu, LL
   Xue, Y
   Luo, T
   Zheng, LP
AF Zeng, Lianjie
   Zhou, Chong
   Xu, Wenqing
   Huang, Yupei
   Wang, Wencan
   Ma, Zhangqiang
   Huang, Jian
   Li, Jia
   Hu, Liaoliao
   Xue, Yue
   Luo, Tao
   Zheng, Liping
TI The ovarian-related effects of polystyrene nanoplastics on human ovarian
   granulosa cells and female mice
SO ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
LA English
DT Article
DE Nanoplastics; Female fertility; Apoptosis; Oxidative stress; Hippo
   pathway; Salidroside
ID HIPPO; ENVIRONMENT; SALIDROSIDE; GROWTH
AB Nanoplastics (NPs) have recently emerged in the context of global plastic pollution. They may be more toxic than macroplastics litter and microplastic fragments due to its abundances, tiny sizes, and cellular accessibility. The female reproductive toxicity of NPs has been widely documented for aquatic animals, but their effects and underlying mechanisms remain poorly understood in mammals. This study aimed to explore the effects of NPs on female reproduction using human ovarian granulosa cells (GCs) and female mice. The accumulation of polystyrene NPs (PS-NPs) in human granulosa-like tumor cells (KGN cells) and the ovaries of female Balb/c mice were evaluated by exposure to fluorescent PS-NPs. Proliferation and apoptosis, reactive oxygen species (ROS), and Hippo signaling pathway-related factors were analyzed in KGN cells. In addition, fertility rate, litter size, ovarian weight and microstructure, follicle development, serum level of anti-Mullerian hormone, and apoptosis in ovaries were examined in female mice. Here, the PS-NPs can penetrate the KGN cells and accumulate in the ovaries. In vitro, 100 mu g/ml PS-NPs inhibited proliferation, induced apoptosis, accumulated ROS, activated three key regulators of the Hippo signaling pathway (MST1, LATS1, and YAP1), and downregulated the mRNA levels of CTGF and Cyr61 in KGN cells. Furthermore, salidroside, an antioxidative compound extracted from Rhodiola rosea, alleviated the damage of PS-NPs to KGN and inhibited the activation of the Hippo signal pathway. In vivo, exposure to 1 mg/day PS-NPs resulted in decreased fertility, abnormal ovarian function, and increased ovarian apoptosis in female mice. Overall, our data suggest that PS-NPs cause granulosa cell apoptosis and affect ovarian functions, leading to reduced fertility in female mice, by inducing oxidative stress and dysregulating the Hippo pathway.
C1 [Zeng, Lianjie; Zhou, Chong; Huang, Yupei; Wang, Wencan; Ma, Zhangqiang; Li, Jia; Xue, Yue; Zheng, Liping] Nanchang Univ, Sch Publ Hlth, Nanchang 330006, Jiangxi, Peoples R China.
   [Zeng, Lianjie; Zhou, Chong; Huang, Yupei; Wang, Wencan; Ma, Zhangqiang; Li, Jia; Xue, Yue; Zheng, Liping] Nanchang Univ, Basic Med Coll, Nanchang 330006, Jiangxi, Peoples R China.
   [Zeng, Lianjie; Zhou, Chong; Xu, Wenqing; Huang, Yupei; Wang, Wencan; Ma, Zhangqiang; Huang, Jian; Li, Jia; Xue, Yue; Luo, Tao; Zheng, Liping] Nanchang Univ, Key Lab Reprod Physiol & Pathol Jiangxi Prov, Nanchang 330006, Jiangxi, Peoples R China.
   [Xu, Wenqing; Luo, Tao] Nanchang Univ, Basic Med Coll, Nanchang 330031, Jiangxi, Peoples R China.
   [Xu, Wenqing; Luo, Tao] Nanchang Univ, Inst Life Sci, Nanchang 330031, Jiangxi, Peoples R China.
   [Wang, Wencan; Ma, Zhangqiang; Zheng, Liping] Nanchang Univ, Jiangxi Prov Key Lab Prevent Med, Nanchang 330006, Jiangxi, Peoples R China.
   [Hu, Liaoliao] Nanchang Univ, Affiliated Hosp 2, Nanchang 330006, Jiangxi, Peoples R China.
C3 Nanchang University; Nanchang University; Nanchang University; Nanchang
   University; Nanchang University; Nanchang University; Nanchang
   University
RP Zheng, LP (corresponding author), Nanchang Univ, Sch Publ Hlth, Nanchang 330006, Jiangxi, Peoples R China.; Luo, T (corresponding author), Nanchang Univ, Basic Med Coll, Nanchang 330031, Jiangxi, Peoples R China.; Luo, T (corresponding author), Nanchang Univ, Inst Life Sci, Nanchang 330031, Jiangxi, Peoples R China.
EM luotao@ncu.edu.cn; zhengliping@ncu.edu.cn
RI Luo, Tao/O-7308-2019; Hu, Liaoliao/MTC-8155-2025; wang,
   wencan/JJE-0260-2023; Xu, Wenqing/IUN-1292-2023
FU National Natural Science Foundations of China
   [82160284/81771583/82071708]; Jiangxi Province Main Academic Disciplines
   and Technology Leaders Training Program [20194BCJ22005]; Jiangxi
   Province Key Projects of Science and Technology Program of Traditional
   Chinese Medicine [2021Z019]; Chongqing Municipal Natural Science
   Foundation [CSTB2022NSCQ- MSX1381]; "Double -Thousand Talents Plan" of
   Jiangxi Province [jxsq2019201091]
FX This work was supported by grants from the National Natural Science
   Foundations of China, Grant/Award Number: 82160284/81771583/82071708;
   Jiangxi Province Main Academic Disciplines and Technology Leaders
   Training Program, Grant/Award Number: 20194BCJ22005; Jiangxi Province
   Key Projects of Science and Technology Program of Traditional Chinese
   Medicine, Grant/Award Number: 2021Z019; Chongqing Municipal Natural
   Science Foundation: CSTB2022NSCQ- MSX1381; "Double -Thousand Talents
   Plan" of Jiangxi Province, Grant/Award Number: jxsq2019201091.
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NR 46
TC 80
Z9 94
U1 11
U2 99
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0147-6513
EI 1090-2414
J9 ECOTOX ENVIRON SAFE
JI Ecotox. Environ. Safe.
PD JUN 1
PY 2023
VL 257
AR 114941
DI 10.1016/j.ecoenv.2023.114941
EA APR 2023
PG 11
WC Environmental Sciences; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Environmental Sciences & Ecology; Toxicology
GA F8ZM1
UT WOS:000985174200001
PM 37087970
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Cai, YW
   Huang, GQ
   Ren, MH
   Chai, YH
   Huang, X
   Yan, TH
AF Cai, Yawen
   Huang, Guiqin
   Ren, Menghui
   Chai, Yuhui
   Huang, Xi
   Yan, Tianhua
TI Synthesizing network pharmacology, bioinformatics, and
   invitro experimental verification to screen candidate
   targets of Salidroside for mitigating Alzheimer's disease
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Article
DE Salidroside; Alzheimer's disease; Pyroptosis; Network pharmacology;
   Molecular docking; Molecular dynamics simulation
AB Alzheimer's disease (AD) is a neurological disorder leading to cognitive deficits. Salidroside (Sal), a primary bioactive ingredient extracted from the roots of Rhodiola rosea L., has potent neuroprotective effects in AD. However, studies on potential targets for Sal-anchored AD are limited. In this study, we combined network pharmacology, bioinformatics, and experimental validation to identify potential targets of Sal treating AD. First, we screened 10 pyroptosis-related genes (PRGs) in Sal and AD using public databases. Then, we used Gene Ontology and the Kyoto Encyclopedia of Genes and Genomes enrichment analysis to explore the biological functions of the shared PRGs (Sal and AD). This finding exhibited that pathways linked to inflammation, like the nucleotide oligomerization domain (NOD)-like receptors signaling pathway, are important for Sal to help fight AD. The GeneMANIA functional results subsequently revealed an association between AD and the processes of inflammasome complex and inflammatory response. Additionally, nine hub genes were identified in the protein-protein interaction network of these shared PRGs. Subsequent analysis of the genes and phenotypes confirmed that these nine hub genes were directly correlated with AD. Subsequently, an in vitro AD model was created using rat adrenal pheochromocytoma cell line (PC12) cells induced by amyloid beta-peptide (A beta) 25-35 (20 mu M). Sal significantly reduced the pyroptosis caused by A beta 25-35 in PC12 cells and decreased the expression levels of IL-1 beta, CASP1, IL-18, PYCARD, and NLRP3. Furthermore, molecular docking and molecular dynamics simulations confirmed that Sal could stably bind to NLRP3. Druggability analysis revealed that Sal had excellent druggability. These results demonstrated that Sal could alleviate AD by targeting IL-1 beta, CASP1, IL-18, PYCARD, and NLRP3 to regulate the NLRP3-mediated pyroptosis signaling pathway.
C1 [Cai, Yawen; Huang, Xi] Nanjing Univ Chinese Med, Inst TCM Related Comorbid Depress, Nanjing, Peoples R China.
   [Huang, Guiqin; Ren, Menghui; Yan, Tianhua] China Pharmaceut Univ, Sch Basic Med Sci & Clin Pharm, Nanjing, Peoples R China.
   [Chai, Yuhui] Second Mil Univ, Shanghai Changhai Hosp, Dept Pharm, Shanghai 200433, Peoples R China.
C3 Nanjing University of Chinese Medicine; China Pharmaceutical University;
   Naval Medical University
RP Huang, X (corresponding author), Nanjing Univ Chinese Med, Inst TCM Related Comorbid Depress, Nanjing, Peoples R China.; Yan, TH (corresponding author), China Pharmaceut Univ, Sch Basic Med Sci & Clin Pharm, Nanjing, Peoples R China.
EM 290606@njucm.edu.cn; 1020050806@cpu.edu.cn
RI Su, Tianyuan/Y-7054-2019; Cai, Yawen/OKR-6198-2025
FU Postgraduate Research & Practice Innovation Program of Jiangsu Province
   [KYCX24_2248]
FX The work was supported by the Postgraduate Research & Practice
   Innovation Program of Jiangsu Province (KYCX24_2248).
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NR 58
TC 4
Z9 5
U1 5
U2 13
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD APR
PY 2025
VL 398
IS 4
BP 4539
EP 4558
DI 10.1007/s00210-024-03555-0
EA NOV 2024
PG 20
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 1DD9G
UT WOS:001348674600001
PM 39503755
DA 2026-05-27
ER

PT J
AU Luo, XP
   Liao, H
   Peng, J
   Jiang, XC
AF Luo, Xiangping
   Liao, Hao
   Peng, Jian
   Jiang, Xiaochun
TI Salidroside Protects Chondrocytes against IL-1β-Induced Injury
   and Alleviates Osteoarthritis Progression by Activating the Nrf2 Pathway
SO DISCOVERY MEDICINE
LA English
DT Article
DE salidroside; IL-1 beta -induced injury; osteoarthritis; Nrf2 pathway
ID OXIDATIVE STRESS; KNEE OSTEOARTHRITIS; NRF2/HO-1; MODEL
AB Background: Osteoarthritis (OA) is a common disease that causes pain to many older adults. Because the pathogenesis is not fully elucidated, effective drug therapies are currently lacking. This study aimed to determine how salidroside (Sal) -mediated reduction of osteoarthritis development in mice worked and to identify the underlying mechanism. Methods: Using in vitro experiments, ATDC5 cells were treated with various concentrations of Sal and interleukin (IL)-1 beta for 24 hours to mimic OA. An enzyme -linked immunosorbent assay (ELISA) was conducted to detect the production of proinflammatory cytokines and reactive oxygen species (ROS). Western blotting was performed to observe the nuclear factor -kappa B (NF-kappa B) and nuclear factor erythroid 2 -related factor 2 (Nrf2) pathways. In in vivo experiments, pathological examination was used to assess the effects of Sal on alleviating OA progression in mice. Nrf2 signaling and its downstream proteins were further tested by immunofluorescence analysis. Results: The results showed that both pro -inflammatory cytokines and ROS were significantly reduced following Sal treatment in a concentration -dependent manner. Western blotting revealed that Sal could inhibit the expression of the NF-kappa B/hypoxia- inducible factor-2 alpha pathway and activate the Nrf2/heme oxygenase-1 pathway. In vivo experiments showed that the cartilage surface in the saline -treated group eroded to a greater extent than the Sal -treated groups (p < 0.001). Immunohistochemistry analysis revealed that matrix metallopeptidase (MMP) 9, MMP13, and a disintegrin and metalloproteinase with thrombospondin motifs -5 (ADAMTS-5) decreased expression level. In contrast, collagen -II and aggrecan increased in the Sal -treated groups compared to the saline -treated group. Conclusions: Our findings indicate that Sal can alleviate OA progression by promoting anti -oxidant expression and inhibiting degradation enzyme expression. These findings suggest that Sal inhibits the NF-kappa B pathway and its downstream targets through up -regulating the Nrf2 pathway.
C1 [Luo, Xiangping; Peng, Jian; Jiang, Xiaochun] Hengyang Cent Hosp, Dept Orthopaed, Hengyang 421001, Hunan, Peoples R China.
   [Liao, Hao] Southern Med Univ, Zhujiang Hosp, Dept Orthopaed, Guangzhou 510280, Guangdong, Peoples R China.
C3 Southern Medical University - China
RP Luo, XP (corresponding author), Hengyang Cent Hosp, Dept Orthopaed, Hengyang 421001, Hunan, Peoples R China.
EM pshxf8@126.com
FU Hengyang science and technology plan project [202250045369]
FX The present study was supported by Hengyang science and technology plan
   project funding (202250045369).
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NR 40
TC 2
Z9 5
U1 1
U2 11
PU DISCOVERY MEDICINE
PI TIMONIUM
PA 10 GERARD AVE, STE 201, TIMONIUM, MD 21093 USA
SN 1539-6509
EI 1944-7930
J9 DISCOV MED
JI Discov. Med.
PD FEB
PY 2024
VL 36
IS 181
BP 266
EP 277
DI 10.24976/Discov.Med.202436181.25
PG 12
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA JC4S1
UT WOS:001170949700005
PM 38409832
OA Bronze
DA 2026-05-27
ER

PT J
AU Qi, ZL
   Qi, SM
   Ling, LF
   Lv, J
   Feng, ZY
AF Qi, Zhilin
   Qi, Shimei
   Ling, Liefeng
   Lv, Jun
   Feng, Zunyong
TI Salidroside attenuates inflammatory response via suppressing JAK2-STAT3
   pathway activation and preventing STAT3 transfer into nucleus
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Salidroside; LPS; JAK2-STAT3; Inflammation; Acute lung injury
ID ACUTE LUNG INJURY; LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION; SIGNALING
   PATHWAY; JAK-STAT; ROS PRODUCTION; KAPPA-B; CELLS; MACROPHAGES; RATS;
   MICE
AB Salidroside (SAL) is an active ingredient isolated from the Rhodiola rosea, has potent anti-inflammatory effect, but the mechanism is still elusive. The purpose of this study is to verify the effects of SAL on LPS-induced inflammatory response and investigate the possible underlying molecular mechanism. RAW264.7 cells were pre incubated with SAL for 2 h, then stimulated with or without LPS for another 16 h. The levels of TNF-alpha, MCP-1, IL-6, and PGE2 were detected by ELISA, and the production of NO was determined by nitrite analysis. The expression levels of nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) were detected by Western blotting. In RAW264.7 cells and murine peritoneal macrophages, the activation of signal molecules was also measured by Western blot. The nuclear translocation of STAT3 was determined by Laser confocal and nucleocytoplasmic separation experiments. Our results showed that SAL attenuated the productions of TNF-alpha, IL-6, MCP-1, PGE2 and NO dose dependently. SAL also suppressed LPS-induced expressions of iNOS and COX-2 significantly. Further studies revealed that SAL down-regulated the phosphorylation of JAK2-STAT3 signaling pathway and reduced the nuclear translocation of STAT3 induced by LPS in RAW264.7 cells and primary peritoneal macrophages. In addition, consistent with the results in vitro, in the model of mice acute lung injury (ALI) induced by LPS, SAL reduced the infiltration of inflammatory cells and decreased the levels of serum TNF-alpha and IL-6 obviously. Taken together, these data indicated that SAL exerted anti-inflammatory action via down-regulating LPS-induced activation of JAX2-STAT3 pathway and suppressing STAT3 transfer into the nucleus at least in part. (C) 2016 Elsevier B.V. All rights reserved.
C1 [Qi, Zhilin; Qi, Shimei; Ling, Liefeng; Lv, Jun] Wannan Med Coll, Dept Biochem, 22 Wenchang West Rd, Wuhu 241002, Anhui, Peoples R China.
   [Qi, Zhilin; Qi, Shimei; Ling, Liefeng; Lv, Jun; Feng, Zunyong] Anhui Prov Key Lab Act Biol Macromols, Wuhu, Anhui, Peoples R China.
C3 Wannan Medical College
RP Qi, ZL (corresponding author), Wannan Med Coll, Dept Biochem, 22 Wenchang West Rd, Wuhu 241002, Anhui, Peoples R China.
EM 422627721@qq.com
FU College Outstanding Young Talent Support Program Key Projects
   [gxyqZD2016173]; Natural Science Research Project of Anhui Colleges and
   Universities [KJ2016SD59]; Natural Science Research Project of Anhui
   Provincial Education Department [KJ2013B311]; National Natural Science
   Foundation of China [31301171]; Key Scientific Research Project of
   Wannan Medical Colleges [WK2015Z01]; Wannan Medical College Doctoral
   Fund, Anhui Province Key Laboratory Of Active Biological Macro-Molecules
   [1306C083008]
FX The work was supported by College Outstanding Young Talent Support
   Program Key Projects (No. gxyqZD2016173), Natural Science Research
   Project of Anhui Colleges and Universities (No. KJ2016SD59), the Natural
   Science Research Project of Anhui Provincial Education Department (No.
   KJ2013B311), National Natural Science Foundation of China (31301171),
   The Key Scientific Research Project of Wannan Medical Colleges
   (WK2015Z01), Wannan Medical College Doctoral Fund, Anhui Province Key
   Laboratory Of Active Biological Macro-Molecules (No. 1306C083008).
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NR 26
TC 68
Z9 81
U1 0
U2 34
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD JUN
PY 2016
VL 35
BP 265
EP 271
DI 10.1016/j.intimp.2016.04.004
PG 7
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA DM2XX
UT WOS:000376212500032
PM 27085677
DA 2026-05-27
ER

PT J
AU Ding, CC
   Guo, ZZ
   Liao, Q
   Zuo, RJ
   He, JJ
   Ye, ZW
   Chen, WB
AF Ding, Chenchun
   Guo, Zhenzhen
   Liao, Quan
   Zuo, Renjie
   He, Junjie
   Ye, Ziwei
   Chen, Weibin
TI Network Pharmacology and Machine Learning Reveal Salidroside's
   Mechanisms in Idiopathic Pulmonary Fibrosis Treatment
SO JOURNAL OF INFLAMMATION RESEARCH
LA English
DT Article
DE salidroside; idiopathic pulmonary fibrosis; network pharmacology;
   machine-learning; molecular docking
AB Purpose: Idiopathic pulmonary fibrosis (IPF) is an irreversible respiratory disease. In this study, we evaluated the efficacy of salidroside (SAL), the main component of Rhodiola rosea, in treating IPF. Methods: The pharmacological effects of SAL against epithelial-mesenchymal transition (EMT) and IPF were assessed through in vivo and in vitro experiments. Targets for SAL in treating IPF were identified from various databases and a PPI network was constructed. Functional analyses of target genes were performed using GO, KEGG, DO, and GSEA. Core target genes were identified using LASSO logistic regression and support vector machine (SVM) analysis, followed by molecular docking simulations. Predicted targets and pathways were validated through Western blotting, qRT-PCR, and IHC. Results: Our results demonstrated that SAL ameliorated alveolar epithelial cells (AECs) EMT and mitigated bleomycin-induced pulmonary fibrosis. Through network pharmacology, we identified 74 targets for SAL in the treatment of IPF (PFDR<0.05) and analyzed their biological functions. Based on these findings, we further applied machine learning techniques to narrow down 9 core targets (PFDR<0.05). Integrating the results from molecular docking, KEGG, and GSEA analyses, we selected three key targets-IGF1, hypoxia-inducible factor 1-alpha (HIF-1 alpha), and MAPK (PFDR<0.05)-for further investigation. Our study revealed that SAL inhibits the IGF1 signaling pathway, thereby improving AECs senescence and cell cycle arrest. By inhibiting the HIF-1 alpha pathway, SAL alleviates endoplasmic reticulum stress and reduces intracellular ROS accumulation. Moreover, SAL suppresses the activation of the MAPK signaling pathway, leading to a decrease in inflammation markers in AECs and lung tissue. Conclusion: Experimental results suggest that SAL effectively ameliorates BLM-induced EMT and IPF, likely through the inhibition of IGF1, HIF-1 alpha, and MAPK signaling pathways. This study holds potential translational prospects and may provide new perspectives and insights for the use of traditional Chinese medicine in the treatment of IPF.
C1 [Chen, Weibin] Xiamen Univ, Zhongshan Hosp, Dept Thorac Surg, Sch Med, Xiamen 361102, Fujian, Peoples R China.
   Xiamen Univ, Sch Pharmaceut Sci, Xiamen 361102, Fujian, Peoples R China.
C3 Xiamen University; Xiamen University
RP Chen, WB (corresponding author), Xiamen Univ, Zhongshan Hosp, Dept Thorac Surg, Sch Med, Xiamen 361102, Fujian, Peoples R China.
EM cwbxmu@163.com
RI ; Liao, Quanyu/GVS-0563-2022
OI 丁, 晨淳/0009-0008-0803-1369; 
FU National Natural Science Foundation of China [81870388]
FX Funding This research was funded by National Natural Science Foundation
   of China, grant number 81870388.
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NR 48
TC 5
Z9 8
U1 4
U2 34
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-7031
J9 J INFLAMM RES
JI J. Inflamm. Res.
PY 2024
VL 17
BP 9453
EP 9467
DI 10.2147/JIR.S493171
PG 15
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA N2I0P
UT WOS:001362622800001
PM 39600682
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Qian, J
   Wang, XH
   Weng, WJ
   Zhou, GX
   Zhu, SX
   Liu, C
AF Qian, Jing
   Wang, Xiaohong
   Weng, Wenjun
   Zhou, Guoxiong
   Zhu, Shunxing
   Liu, Chun
TI Salidroside alleviates taurolithocholic acid 3-sulfate-induced AR42J
   cell injury
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE Salidroside; Taurolithocholic acid 3-sulfate; AR42J cell; Inflammatory
   response; Autophagy; Nuclear factor kappa B
ID ACTIVATION; AUTOPHAGY; INFLAMMATION
AB Objectives: To investigate the protective effects of Salidroside (Sal) on AP cell model induced by taurolithocholic acid 3-sulfate (TLC-S) as well as its underlying mechanism. Methods: AR42J cells were divided into normal group (N group), AP cell model group (Mod group), Sal treated alone group (S+N group) and Sal treated AP cell model group (S+Mod group). The cell viability was examined by CCK-8 assay. Secretion of lipase and trypsin by AR42J cells, quantified using commercial assay kits, was used as the markers of TLC-S-induced pancreatitis. The levels of TNF-alpha, IL-1 beta, IL-8, IL-6 and IL-10 in the cell supernatant were measured by ELISA. The effect of Sal on molecules in the NF-Kappa B signaling pathway and autophagy was investigated by qRT-PCR and western blot. Results: The decreased cell viability in Mod group was increased by Sal (P < 0.01). The upheaved activities of lipase and trypsin in AP cell model were declined by Sal (P < 0.01). The levels of TNF-alpha, IL-1 beta, IL-8 and IL-6 in the cell supernatant, Beclin-1 and LC3-II mRNA and protein, p-p65/p65 protein, which were increased in AP cell model, were decreased by Sal; and IL-10 in the cell supernatant, LAMP2 mRNA and protein, p-I Kappa B alpha/I Kappa B alpha protein which was declined in AP cell model, was increased by Sal (P < 0.05 or 0.01). There were no significant differences in all indexes between the N and S+N groups (P > 0.05). Conclusions: Sal alleviated AR42J cells injury induced by TLC-S, inhibited the inflammatory responses and modulated the autophagy, mainly through inhibiting the NF-Kappa B signaling pathway.
C1 [Qian, Jing] Nanjing Drum Tower Hosp Grp, Yizheng Hosp, Dept Gen Surg, Yizheng 211900, Jiangsu, Peoples R China.
   [Wang, Xiaohong] Nanjing Drum Tower Hosp Grp, Yizheng Hosp, Dept Gastroenterol, Yizheng 211900, Jiangsu, Peoples R China.
   [Weng, Wenjun] Nanjing Drum Tower Hosp Grp, Yizheng Hosp, Dept Cardiothorac Surg, Yizheng 211900, Jiangsu, Peoples R China.
   [Zhou, Guoxiong] Nantong Univ, Affiliated Hosp, Dept Gastroenterol, Nantong 226001, Jiangsu, Peoples R China.
   [Zhu, Shunxing; Liu, Chun] Nantong Univ, Lab Anim Ctr, Nantong 226001, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University
RP Wang, XH (corresponding author), Living Area Sinopec Yizheng Chem Fibre CO LTD, Yizheng Hosp, Nanjing Drum Tower Hosp Grp, 1 Huannan Rd, Yizheng 211900, Jiangsu, Peoples R China.
EM qianjing998@163.com; wx102474wx@163.com; wwjlyj284@163.com;
   zhougx@ntu.edu.cn; zsx@ntu.edu.cn; liuchun@ntu.edu.cn
RI Wang, Xiaohong/JXL-8370-2024
FU Administration of Traditional Chinese Medicine of Jiangsu Province,
   China [YB2020088]; Health innovation project of Lvyang Jinfeng plan of
   Yangzhou City in 2020, China [LJ202037]
FX The study was supported by the Administration of Traditional Chinese
   Medicine of Jiangsu Province, China (No.: YB2020088) and the Health
   innovation project of Lvyang Jinfeng plan of Yangzhou City in 2020,
   China (No.: LJ202037) .
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NR 51
TC 14
Z9 14
U1 0
U2 11
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD OCT
PY 2021
VL 142
AR 112062
DI 10.1016/j.biopha.2021.112062
EA AUG 2021
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA UR7XS
UT WOS:000696957900006
PM 34435589
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Guo, W
   Huang, R
   Bian, JJ
   Liao, Q
   You, J
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   Wang, YQ
   Wen, D
   Fan, XC
   Zhou, CY
   Xu, ZM
AF Guo, Wen
   Huang, Rong
   Bian, Jiaojiao
   Liao, Qing
   You, Jun
   Yong, Xi
   Wang, Yuquan
   Wen, Dan
   Fan, Xiaochun
   Zhou, Chunyang
   Xu, Zhengmin
TI Salidroside ameliorates macrophages lipid accumulation and
   atherosclerotic plaque by inhibiting Hif-1α-induced pyroptosis
SO BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
LA English
DT Article
DE Salidroside; Hif-1 alpha; Pyroptosis; Macrophages-derived foam cells;
   Atherosclerosis
ID CELLS
AB Background: Hipoxia-inducible factor 1 alpha (Hif-1 alpha) is a significant risk factor for atherosclerotic cardiovascular disease. Salidroside (SAL) has demonstrated anti-oxidative and anti-cardiovascular disease effects. Currently, there are no relevant studies investigating the interaction between SAL and Hif-1 alpha in the progression of atherosclerosis. Methods: Hif-1 alpha was either knocked down or upregulated in Ana-1 macrophages-derived foam cells, and atherosclerosis ApoE- /- mice were treated with or without SAL. A Protein-protein network involving Hif-1 alpha and pyroptosis-related genes was identified through bioinformatic analysis and validated in human vascular tissues. The Oil Red O and DiI staining were used to detect the intracellular ox-LDL accumulation. The HE and Oil Red O staining were employed to evaluate atherosclerotic plaque in vivo. The levels of relevant molecules were quantified using WB, qRT-PCR, ELISA, and immunohistochemistry. The target proteins of SAL were identified through Molecular docking and Cell Thermal Shift Assay (CESTA). Results: Both Hif-1 alpha knockdown and SAL treatment markedly reduced lipid accumulation in macrophagesderived foam cells. Hif-1 alpha was closely associated with Caspase1, Gsdmd, NRLP3, and IL-1 beta, and co-located in CD86+ macrophages-derived foam cells within atherosclerotic plaque. SAL inhibited Hif-1 alpha-induced Caspase-1dependent pyroptosis and lipid accumulation by directly bonding to Hif-1 alpha. In vivo, SAL treatment decreased atherosclerotic plaque and improved plasma lipid profiles. Furthermore, SAL reduced M1 macrophages infiltration and the levels of Hif-1 alpha, C-Caspase1, Gsdmd-N, NRLP3, IL-18, and IL-1 beta in atherosclerotic plaque. Conclusion: SAL alleviated the lipid accumulation in macrophages and atherosclerotic plaques by inhibiting pyroptosis pathway via directly binding to Hif-1 alpha, which may be a promising therapeutic strategy for AS treatment.
C1 [Guo, Wen; Huang, Rong; Bian, Jiaojiao; Liao, Qing; You, Jun; Zhou, Chunyang; Xu, Zhengmin] North Sichuan Med Coll, Inst Materia Med, Sch Pharm, Nanchong 637000, Peoples R China.
   [Guo, Wen; Yong, Xi; Wang, Yuquan; Wen, Dan] North Sichuan Med Coll, Pharm Dept, Dept Vasc Surg, Cardiovasc Med,Nucl Med,Affiliated Hosp, Nanchong 637000, Peoples R China.
   [Guo, Wen] Nanchong Hlth Sch Sichuan Prov, Affiliated Hosp, Nanchong 637000, Peoples R China.
   [Fan, Xiaochun] Nanchong Hosp Tradit Chinese Med, Key Lab Tradit Chinese med prevent & treatment ske, Nanchong 637000, Peoples R China.
C3 North Sichuan Medical University; North Sichuan Medical University
RP Zhou, CY; Xu, ZM (corresponding author), North Sichuan Med Coll, Inst Materia Med, Sch Pharm, Nanchong 637000, Peoples R China.
EM zhouchunyang@nsmc.edu.cn; xuzhengmin@nsmc.edu.cn
RI /AAO-7524-2020
FU Affiliated Hospital of North Sichuan Medical College Science and
   Technology Development Plan [2020ZD002, 2022JC018]; First-class
   Pharmaceutical Sciences of North Sichuan Medical College [CBY21-YLXK03];
   North Sichuan Medical College PhD Research Fund [CBY21-QD08]; Project of
   North Sichuan Medical College [CBY21-ZD05]; National College Student
   Innovation and Entrepreneurship Training Program Project [202210634031];
   Natural Science Foundation of Sichuan [2022NSFSC1350]; Sichuan Province
   science and technology plan project [2020YJ0381]; Project of Sichuan
   Provincial Administration of traditional Chinese Medicine [2021MS033];
   The free exploring of the Natural Science cooperation project between
   university and Nanchong City [22SXQT0006]; Research and Development
   Plan, Science and Technology Achievement Transformation and Cultivation
   Project of North Sichuan Medical college [CBY22-ZH01]; The Development
   of scientific research of the affiliated hospital of North Sichuan
   Medical college [2022JC018];  [2020ZD004];  [S202410634100]
FX This work was supported by Affiliated Hospital of North Sichuan Medical
   College Science and Technology Development Plan (2020ZD002, 2020ZD004,
   2022JC018) , the First-class Pharmaceutical Sciences of North Sichuan
   Medical College (CBY21-YLXK03) , North Sichuan Medical College PhD
   Research Fund (CBY21-QD08) , Project of North Sichuan Medical College
   (CBY21-ZD05) , National College Student Innovation and Entrepreneurship
   Training Program Project (202210634031, S202410634100) , Natural Science
   Foundation of Sichuan (2022NSFSC1350) , Sichuan Province science and
   technology plan project (2020YJ0381) , Project of Sichuan Provincial
   Administration of traditional Chinese Medicine (2021MS033) , The free
   exploring of the Natural Science cooperation project between university
   and Nanchong City (22SXQT0006) , Research and Development Plan, Science
   and Technology Achievement Transformation and Cultivation Project of
   North Sichuan Medical college (CBY22-ZH01) , The Development of
   scientific research of the affiliated hospital of North Sichuan Medical
   college (2022JC018) .
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NR 44
TC 11
Z9 13
U1 4
U2 12
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0006-291X
EI 1090-2104
J9 BIOCHEM BIOPH RES CO
JI Biochem. Biophys. Res. Commun.
PD JAN
PY 2025
VL 742
AR 151104
DI 10.1016/j.bbrc.2024.151104
EA DEC 2024
PG 10
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA T8S6C
UT WOS:001407639900001
PM 39642710
DA 2026-05-27
ER

PT J
AU Li, CL
   Chi, JJ
   Dai, HY
   Liang, M
   Wang, YY
   Tian, SX
   Zhu, HY
   Xu, H
AF Li, Chunli
   Chi, Jiejun
   Dai, Hongyan
   Liang, Ming
   Wang, Yangyang
   Tian, Songxin
   Zhu, Huiyan
   Xu, Hai
TI Salidroside attenuates cerebral ischemia/reperfusion injury by
   regulating TSC2-induced autophagy
SO EXPERIMENTAL BRAIN RESEARCH
LA English
DT Article
DE Salidroside; Cerebral ischemia; reperfusion injury; 5 '-AMP-activated
   protein kinase; TSC complex subunit 2; Autophagy
ID REPERFUSION INJURY; OXIDATIVE STRESS; ISCHEMIA; PROTECTS; INFLAMMATION;
   APOPTOSIS; MICE
AB Salidroside (SAL), an antioxidant derived from Rhodiola rosea, exerts neuroprotective effects in cerebral ischemia/reperfusion (I/R) injury; however, the mechanisms have not been fully elucidated. The present study established a rat model of middle cerebral artery occlusion/reperfusion (MCAO/R) and a cellular model of oxygen-glucose deprivation/reoxygenation (OGD/R) to explore the roles and mechanisms of SAL in cerebral I/R injury. The rat model of MCAO/R was established and rats were treated with different doses of SAL. The Zea-Longa scoring system and 2,3,5-triphenyltetrazolium chloride (TTC) staining showed that SAL reduced neurological deficit scores and cerebral infarct volumes in MCAO/R rats. The results of Morris water maze (MWM) test showed that SAL reduced memory impairment in MCAO/R rats. In addition, SAL significantly reduced oxidative stress and suppressed inflammatory response. Next, the OGD/R model was established with PC12 cells and treated with SAL. The results of flow cytometry and 3-(4, 5-dimethylthiazolyl-2)-2,5-diphenyltetrazolium bromide (MTT) assays showed that SAL reduced apoptosis, enhanced cell viability and protected neuronal cells from damage by decreasing lactate dehydrogenase (LDH) activity. SAL increased the expression of TSC complex subunit 2 (TSC2), and activated the 5 '-AMP-activated protein kinase (AMPK) and inhibited the mammalian target of rapamycin (mTOR) signaling pathways. It was verified that SAL alleviated cerebral I/R injury by regulating the AMPK/TSC2/mTOR pathway to induce autophagy. In conclusion, SAL reduces the inflammatory response and oxidative stress in a concentration-dependent manner, and protects against cerebral I/R injury by modulating TSC2-induced autophagy. These findings suggest SAL may prove to be a potential therapeutic agent for ischemic stroke.
C1 [Li, Chunli; Chi, Jiejun; Liang, Ming; Wang, Yangyang; Tian, Songxin; Zhu, Huiyan; Xu, Hai] Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Rehabil Med, 91 Tianchi Rd, Urumqi 830001, Xinjiang, Peoples R China.
   [Dai, Hongyan] Xinjiang Med Univ, Funct Ctr Sch Basic Med Sci, Urumqi 830054, Xinjiang, Peoples R China.
C3 Xinjiang Medical University
RP Xu, H (corresponding author), Peoples Hosp Xinjiang Uygur Autonomous Reg, Dept Rehabil Med, 91 Tianchi Rd, Urumqi 830001, Xinjiang, Peoples R China.
EM klmyjy@21cn.com; chijiejun@163.com; 414941636@qq.com; wszsydxs@163.com;
   micelle1992@163.com; tsx0316@163.com; 18040833147@163.com;
   xuhaixj1972@sina.com
OI Li, Chunli/0000-0001-7095-5820
FU Xinjiang Uygur Autonomous Region Health young medical science and
   technology talents special research project [wjwy-202026]; General
   projects of Natural Science Foundation of Xinjiang Uygur Autonomous
   Region [2021D01C131]
FX The present study was supported by Xinjiang Uygur Autonomous Region
   Health young medical science and technology talents special research
   project (No. wjwy-202026) and General projects of Natural Science
   Foundation of Xinjiang Uygur Autonomous Region (No. 2021D01C131).
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NR 43
TC 7
Z9 10
U1 0
U2 11
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0014-4819
EI 1432-1106
J9 EXP BRAIN RES
JI Exp. Brain Res.
PD JAN
PY 2023
VL 241
IS 1
BP 113
EP 125
DI 10.1007/s00221-022-06493-6
EA NOV 2022
PG 13
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 8J9IP
UT WOS:000883221300001
PM 36374318
DA 2026-05-27
ER

PT J
AU Yuan, Y
   Wang, ZY
   Nan, B
   Yang, CY
   Wang, MH
   Ye, HQ
   Xi, CY
   Zhang, Y
   Yan, HY
AF Yuan, Yuan
   Wang, Ziyue
   Nan, Bo
   Yang, Chaoyue
   Wang, Minghua
   Ye, Haiqing
   Xi, Chunyu
   Zhang, Yan
   Yan, Haiyang
TI Salidroside alleviates liver inflammation in furan-induced mice by
   regulating oxidative stress and endoplasmic reticulum stress
SO TOXICOLOGY
LA English
DT Article
DE Furan; Salidroside (SAL); Oxidative stress (OS); Endoplasmic reticulum
   stress (ERS); Inflammation; NLRP3 inflammasome
ID FACTOR-KAPPA-B; NLRP3 INFLAMMASOME; ER STRESS; DOWN-REGULATION;
   ACTIVATION; HEPATOCYTES; INHIBITION; METABOLISM; EXPRESSION; APOPTOSIS
AB Furan is a genotoxic and carcinogenic toxicant formed during the food thermal processing. Our previous studies confirmed that salidroside (SAL) displayed excellent protective effects against furan-induced hepatotoxicity and inflammation, whereas the underlying mechanism was still unclear. In the current study, Balb/c mice were divided to the control group (CON), the furan model group (FUR8, 8 mg/kg BW furan for 30 days) and SAL intervention groups (SAL10/20/40, 8 mg/kg BW furan for 30 days + 10/20/40 mg/kg BW SAL from day 16 to day 30). The alleviative effects and the mechanisms of SAL against furan-induced liver inflammation in mice were investigated through oxidative stress (OS) and endoplasmic reticulum stress (ERS). Liver metabonomics data, molecular docking and Western-blotting results implied that SAL suppressed the activity and the high expression of hepatic CYP2E1, and alleviated liver OS induced by furan. Levels of key markers (GRP78, CHOP and Caspase-12) of ERS and proteins in IRE1 alpha pathway of the UPR branch increased by furan were prominently reduced after SAL treatment. Levels of phosphorylated proteins JNK, ERK, p38, IKK alpha/beta, I kappa B and p65 in MAPK and NF-kappa B pathways were also suppressed by SAL. We further confirmed that SAL inhibited furan-induced inflammation by reducing the levels of NLRP3, ASC, Cleaved Caspase-1 and IL-1 beta and decreasing the production of pro-inflammatory cytokines. Our results shed light into the alleviating mechanisms behind furan-induced liver inflammation, and suggested that SAL inhibited OS, ERS and related MAPK and NF-kappa B pathways and therefore inhibited the NLRP3 inflammasome activation, which may be its potential mechanism of alleviating liver inflammation.
C1 [Yuan, Yuan; Wang, Ziyue; Nan, Bo; Yang, Chaoyue; Wang, Minghua; Ye, Haiqing; Xi, Chunyu; Yan, Haiyang] Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Peoples R China.
   [Zhang, Yan] Jilin Univ, Coll Phys, Changchun 130062, Peoples R China.
C3 Jilin University; Jilin University
RP Yan, HY (corresponding author), Jilin Univ, Coll Food Sci & Engn, Changchun 130062, Peoples R China.
EM yanhyjlu@163.com
RI yuan, Yuan/ISA-0923-2023
FU National Natural Science Foundation of China [31972181]
FX This work was supported by a fund from the National Natural Science
   Foundation of China (No. 31972181). The authors gratefully acknowledge
   the fund's supports.
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NR 65
TC 28
Z9 32
U1 0
U2 61
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0300-483X
EI 1879-3185
J9 TOXICOLOGY
JI Toxicology
PD SEP
PY 2021
VL 461
AR 152905
DI 10.1016/j.tox.2021.152905
EA AUG 2021
PG 10
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA UQ7XC
UT WOS:000696272700014
PM 34450210
DA 2026-05-27
ER

PT J
AU Qian, C
   Liang, SZ
   Wan, GM
   Dong, Y
   Lu, TY
   Yan, PS
AF Qian, Cheng
   Liang, Shenzhi
   Wan, Guangming
   Dong, Yi
   Lu, Taiying
   Yan, Panshi
TI RETRACTED: Salidroside alleviates high-glucose-induced injury in retinal
   pigment epithelial cell line ARPE-19 by down-regulation of miR-138
   (Retracted Article)
SO RNA BIOLOGY
LA English
DT Article; Retracted Publication
DE Diabetic retinopathy; Salidroside; microRNA-138; PI3K; AKT; AMPK
ID DIABETIC-RETINOPATHY; OXIDATIVE STRESS; INFLAMMATORY RESPONSE;
   ENDOTHELIAL-CELLS; KAPPA-B; ACTIVATION; EXPRESSION; PROTECTS; CYCLE;
   ANGIOGENESIS
AB Diabetic retinopathy (DR) is a complication of diabetes leading cause of blindness in adults. Salidroside (SAL) is a main ingredient from Rhodiola rosea L., has been reported to have a beneficial protection on vascular function. However, whether SAL is a suitable treatment for DR remains unreported. The study aimed to investigate the effect of SAL on high-glucose (HG)-induced injury in ARPE-19 cells. ARPE-19 cells were managed with diverse concentrations of glucose, and constructed a model of HG-induced ARPE-19 cells injury. Then, SAL was employed to stimulate ARPE-19 cells, and cell viability, apoptosis, apoptosis-associated factors, the pro-inflammatory cytokines, and ROS levels were determined. The correlation between miR-138 and SIRT1 was predicated by bioinformatics software of TargetScan (http://www.targetscan.org/) and Dual luciferase reporter assay. MiR-138 mimic, inhibitor and NCs were transfected into ARPE-19 cells, and the impacts of miR-138 on HG-induced cell injury were investigated. PI3K/AKT and AMPK signalling pathways were examined to explore the underlying mechanism. The results disclosed that HG inhibited cell viability, promoted apoptosis, up-regulated IL-6 and TNF-alpha, as well as increased ROS level in ARPE-19 cells. But, SAL obviously alleviated HG-induced ARPE-19 cells injury. Repressed miR-138 was triggered by SAL, and SIRT1 was predicated as a direct target of miR-138. Overexpressed miR-138 declined the protective effect of SAL on HG-injured ARPE-19 cells. Besides, SAL activated PI3K/AKT and AMPK pathways by adjusting miR-138. In conclusions, SAL flattened HG-induced injury in ARPE-19 cells by repression of miR-138 and activating PI3K/AKT and AMPK pathways.
C1 [Qian, Cheng; Liang, Shenzhi; Wan, Guangming; Dong, Yi; Lu, Taiying; Yan, Panshi] Zhengzhou Univ, Dept Ophthalmol, Affiliated Hosp 1, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China.
C3 Zhengzhou University
RP Wan, GM (corresponding author), Zhengzhou Univ, Dept Ophthalmol, Affiliated Hosp 1, 1 Jianshe East Rd, Zhengzhou 450052, Henan, Peoples R China.
EM wangm0507@yeah.net
FU National Key R&D Program of China [2018YFA0107304, 2017YFA0105000]; Plan
   For Scientific Innovation Talent of Henan Province [184200510005]
FX The study was supported by National Key R&D Program of China
   (No.2018YFA0107304, No.2017YFA0105000) and Plan For Scientific
   Innovation Talent of Henan Province (No.184200510005).
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NR 45
TC 23
Z9 26
U1 0
U2 23
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 1547-6286
EI 1555-8584
J9 RNA BIOL
JI RNA Biol.
PD OCT 3
PY 2019
VL 16
IS 10
BP 1461
EP 1470
DI 10.1080/15476286.2019.1637696
EA JUL 2019
PG 10
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA IU5YK
UT WOS:000476304500001
PM 31251107
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU Zhang, P
   Xu, JZ
   Cui, QF
   Lin, GQ
   Wang, FY
   Ding, XY
   You, SX
   Sang, NN
   Tan, JC
   Xu, WW
   Zhan, CS
   Zhu, YY
   Zhang, JG
AF Zhang, Pei
   Xu, Jiazhen
   Cui, Qianfei
   Lin, Guoqiang
   Wang, Feiyun
   Ding, Xinyue
   You, Suxin
   Sang, Nina
   Tan, Junchao
   Xu, Wenwen
   Zhan, Changsen
   Zhu, Yuying
   Zhang, Jiange
TI Multi-pathway neuroprotective effects of a novel salidroside derivative
   SHPL-49 against acute cerebral ischemic injury
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE Ischemic stroke; Neuroprotective; Salidroside derivative; Oxidative
   stress; Apoptosis
ID RADICAL SCAVENGER; STROKE; RECOMMENDATIONS; EDARAVONE
AB SHPL-49 ((2R,3S,4S,5R,6R)-2-(hydroxymethyl)-6-(4-(4-methoxyphenyl) butoxy) tetrahydro-2H-pyran-3,4,5-triol) is a novel glycoside derivative obtained from structural modification of salidroside, which is isolated from the medicinal plant Rhodiola rosea L. SHPL-49 was administered to rats with permanent middle cerebral artery occlusion (pMCAO) for 5 days, and it was found that SHPL-49 could alleviate the cerebral infarct volume and reduce the neurological deficit score. Moreover, the effective time window of SHPL-49 in the pMCAO model was from 0.5 to 8 h after embolization. In addition, the result of immunohistochemistry showed that SHPL-49 could increase the number of neurons in the brain tissue and reduce the occurrence of apoptosis. Morris water maze and Rota-rod experiments showed that SHPL-49 could improve neurological deficits, repair neurocognitive and motor dysfunction, and enhance learning and memory ability in the pMCAO model after 14 days of SHPL-49 treatment. Further in vitro experiments showed that SHPL-49 significantly reduced the calcium overload of PC-12 cells and the production of reactive oxygen species (ROS) induced by oxygen and glucose deprivation (OGD), and increased the levels of antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), decreased the production of malondialdehyde (MDA). Furthermore, SHPL-49 could reduce cell apoptosis by increasing protein expression ratio of anti-apoptotic factor Bcl-2 to pro-apoptotic factor Bax in vitro. SHPL-49 also regulated the expression of Bcl-2 and Bax in ischemic brain tissue, and even inhibited the caspase cascade of pro-apoptotic proteins Cleaved-caspase 9 and Cleaved-caspase 3. Taken together, SHPL-49 exhibited neuroprotective effects against cerebral ischemic injury through multiple pathways, such as alleviating calcium overload, reducing oxidative stress damage, and inhibiting apoptosis.
C1 [Zhang, Pei; Xu, Jiazhen; Cui, Qianfei; Lin, Guoqiang; Wang, Feiyun; Ding, Xinyue; You, Suxin; Sang, Nina; Tan, Junchao; Zhu, Yuying; Zhang, Jiange] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med IRI, Res Ctr Chiral Drugs, Shanghai 201203, Peoples R China.
   [Xu, Wenwen; Zhan, Changsen] Shanghai Hutchison Pharmaceut Ltd, Shanghai Engn Res Ctr Innovat Solid Preparat TCM, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Zhang, JG (corresponding author), Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit Chinese Med IRI, Res Ctr Chiral Drugs, Shanghai 201203, Peoples R China.; Zhan, CS (corresponding author), Shanghai Hutchison Pharmaceut Ltd, Shanghai Engn Res Ctr Innovat Solid Preparat TCM, Shanghai, Peoples R China.
EM jgzhang@shutcm.edu.cn
RI Xu, Wenwen/AAD-9116-2019; Zhu, Yuying/KHU-1439-2024; Cui,
   Qianfei/OHT-1728-2025; Ding, Xin-yue/MSZ-4912-2025
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NR 42
TC 16
Z9 20
U1 1
U2 22
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD JUN 15
PY 2023
VL 949
AR 175716
DI 10.1016/j.ejphar.2023.175716
EA APR 2023
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA M9RF7
UT WOS:001033506600001
PM 37059375
DA 2026-05-27
ER

PT J
AU Yi, QQ
   Liang, PC
   Liang, DY
   Cao, LO
   Sha, S
   Jiang, XQ
   Chang, Q
AF Yi, Qingqing
   Liang, Pengchen
   Liang, Dongyu
   Cao, Liou
   Sha, Shuang
   Jiang, Xinquan
   Chang, Qing
TI Improvement of polydopamine-loaded salidroside on osseointegration of
   titanium implants
SO CHINESE MEDICINE
LA English
DT Article
DE Titanium; Microarc oxidation; Polydopamine; Salidroside; Osteogenesis;
   Angiogenesis
ID MECHANISMS; VEGF; MAO
AB Background Microarc oxidation (MAO) on the surface of medical pure titanium can improve its histocompatibility, and loading drugs on the surface can resist excessive intimal hyperplasia. Methods In this study, salidroside (SAL) was loaded on the surface of porous titanium (Ti) with polydopamine (PDA) carrier. The effects of SAL on the osteogenesis and angiogenesis of Ti implants were studied by phalloidin staining, alizarin red staining, ALP staining, wound-healing assay, cell transwell assay, matrigel tube formation, and osteogenic and angiogenic genes and proteins expression detected by PCR and western blot in vitro. The bone defect model experiments in rats was established in vivo including X-ray, micro CT, hematoxylin and eosin staining (HE), immunohistochemistry (IHC), Goldner's trichrome analysis, Safranin O-fast green staining and determination of contents of TNF-alpha and IL-6 in serum. Results EDS and EDS mapping showed that SAL could be loaded on the surface of the MAO coating by PDA. A drug release experiment showed that SAL loaded on the Ti coating could release slowly and stably without sudden release risk. In vitro cell experiments showed that the SAL coating could promote the proliferation, morphology, calcification and alkaline phosphate activity of MC3T3-E1 cells. At the same time, it promoted the migration and tube formation of HUVEC cells. The SAL coating promoted osteogenesis and angiogenesis by promoting the expression of genes and proteins related to. In vivo experiments, HE and IHC showed that SAL significantly promoted the expression of COL-1 and CD31. Goldner's trichrome and Safranin O-fast green staining showed that SAL coating could increase the new bone tissue around the implantation site. The SAL coating had anti-inflammatory activity by reducing the levels of TNF-alpha and IL-6 in vivo. Conclusion Therefore, SAL could improve osteogenesis and angiogenesis in conjunction with the Ti-PDA coating.
C1 [Yi, Qingqing; Liang, Dongyu; Cao, Liou; Chang, Qing] Shanghai Univ Med & Hlth Sci, Clin Res Ctr, Jiading Dist Cent Hosp, Shanghai 201800, Peoples R China.
   [Liang, Pengchen] Shanghai Univ, Sch Microelect, Shanghai 201800, Peoples R China.
   [Sha, Shuang] Shanghai Univ Med & Hlth Sci, Shanghai Key Lab Mol Imaging, Shanghai 201318, Peoples R China.
   [Jiang, Xinquan] Shanghai Jiao Tong Univ, Sch Med, Coll Stomatol,Dept Prosthodont,Shanghai Key Lab S, Shanghai Peoples Hosp 9,Shanghai Engn Res Ctr Adv, Shanghai 200011, Peoples R China.
   [Jiang, Xinquan] Shanghai Jiao Tong Univ, Sch Med, Coll Stomatol,Natl Clin Res Ctr Oral Dis, Shanghai Peoples Hosp 9,Shanghai Res Inst Stomato, Shanghai 200011, Peoples R China.
C3 Shanghai University of Medicine & Health Sciences; Shanghai University;
   Shanghai University of Medicine & Health Sciences; Shanghai Jiao Tong
   University; Shanghai Jiao Tong University
RP Chang, Q (corresponding author), Shanghai Univ Med & Hlth Sci, Clin Res Ctr, Jiading Dist Cent Hosp, Shanghai 201800, Peoples R China.
EM qingchang0510@163.com
RI liang, dongying/GZA-4770-2022
OI Jiang, Xinquan/0000-0002-1490-281X; pengchen, liang/0000-0002-7475-373X
FU Nature Science Foundation of Jiading District, Shanghai
   [JDKW-2020-0013]; Key Projects of Jiading District Health Commission,
   Shanghai [2020-ZD-03]; Clinical Research Fundation of Shanghai
   University of Medicine & Health Sciences [20MC2020004]
FX The work was supported by the Nature Science Foundation of Jiading
   District, Shanghai (No. JDKW-2020-0013), the Key Projects of Jiading
   District Health Commission, Shanghai (No. 2020-ZD-03) and Clinical
   Research Fundation of Shanghai University of Medicine & Health Sciences
   (No. 20MC2020004).
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NR 31
TC 15
Z9 18
U1 2
U2 60
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
SN 1749-8546
J9 CHIN MED-UK
JI Chin. Med.
PD FEB 21
PY 2022
VL 17
IS 1
AR 26
DI 10.1186/s13020-022-00569-9
PG 17
WC Integrative & Complementary Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine; Pharmacology & Pharmacy
GA ZE3RW
UT WOS:000758805100001
PM 35189918
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Luan, X
   Cui, CN
   Jiang, JZ
   Wang, CY
   Li, L
   Li, HZ
   Xu, C
   Li, LC
   Chi, YX
   Yan, GH
AF Luan, Xue
   Cui, Chunai
   Jiang, Jingzhi
   Wang, Chongyang
   Li, Li
   Li, Hongzi
   Xu, Chang
   Li, Liangchang
   Chi, Yongxue
   Yan, Guanghai
TI Salidroside Mitigates Airway Inflammation in Asthmatic Mice via the
   AMPK/Akt/GSK3β Signaling Pathway
SO INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY
LA English
DT Article
DE Salidroside; Acute asthma; Airway inflammation; Th1/Th2 imbalance;
   AMPK/Akt/GSK3 beta
ID MURINE MODEL; ACTIVATION; CELLS; INTERLEUKIN-5; INTERFERON; INJURY; ACID
AB Introduction: This study aimed to explore the effects and mechanisms of salidroside (SAL) in airway inflammation in asthmatic mice. Methods: Mice were sensitized with ovalbumin (OVA) to establish an asthma model. They were divided into the control group, OVA group, SAL low-dose group (SAL-L), SAL high-dose group (SAL-H), and dexamethasone (DXM) group. The airway reactivity of the mice was measured, and the total cells, neutrophils, eosinophils, and lymphocytes were counted, respectively. The levels of IL-4, IL-5, IL-13, and IFN-gamma in bronchoalveolar lavage fluid (BALF) were detected by ELISA. Immunohistochemistry was used to detect the expression levels of p-AMPK, p-Akt, and p-GSK3 beta. Western blot was used to detect cytokine levels in lung tissue and p-AMPK, p-Akt, and p-GSK3 beta levels in LPS-induced 16HBE cells. Results: The airway hyperresponsiveness of asthmatic mice in the SAL-H group decreased (p < 0.05), and the total number of cells, neutrophils, eosinophils, and lymphocytes decreased significantly (p < 0.05). In addition, the airways of mice showed airway inflammatory infiltration and goblet cell proliferation, and the corresponding cellular inflammatory factors IL-4, IL-5, and IL-13 were significantly decreased. However, the expression of IFN-gamma in BALF and lung tissues was increased (p < 0.05). Moreover, after the mice were treated with SAL, the phosphorylation level of AMPK was significantly increased, which further reduced the phosphorylation levels of Akt and GSK3 beta (p < 0.05). Both SAL and AMPK inhibitors exerted effects on LPS-induced 16HBE cells, consistent with in vivo results. Conclusion: SAL can inhibit bronchial hyperresponsiveness and reduce tracheal inflammation by increasing AMPK phosphorylation and inhibiting Akt and GSK3 beta signaling pathways.
C1 [Luan, Xue; Li, Hongzi; Chi, Yongxue] Yanbian Univ, Dept Pediat, Affiliated Hosp, Jilin, Jilin, Peoples R China.
   [Luan, Xue] First Hosp Jilin Univ, Dept Pediat, Jilin, Jilin, Peoples R China.
   [Luan, Xue; Cui, Chunai; Jiang, Jingzhi; Wang, Chongyang; Li, Li; Li, Hongzi; Xu, Chang; Li, Liangchang; Chi, Yongxue; Yan, Guanghai] Yanbian Univ, Jilin Key Lab Immune & Targeting Res Common Aller, Yanji, Peoples R China.
   [Cui, Chunai; Jiang, Jingzhi; Wang, Chongyang; Li, Li; Xu, Chang; Li, Liangchang; Yan, Guanghai] Yanbian Univ, Dept Anat Histol & Embryol, Med Coll, Jilin, Jilin, Peoples R China.
C3 Yanbian University; Yanbian University; Yanbian University
RP Chi, YX (corresponding author), Yanbian Univ, Dept Pediat, Affiliated Hosp, Jilin, Jilin, Peoples R China.; Chi, YX; Yan, GH (corresponding author), Yanbian Univ, Jilin Key Lab Immune & Targeting Res Common Aller, Yanji, Peoples R China.; Yan, GH (corresponding author), Yanbian Univ, Dept Anat Histol & Embryol, Med Coll, Jilin, Jilin, Peoples R China.
EM chiyongxue@aliyun.com; ghyan2015@sina.com
RI ; Xu, Chang/LDG-7745-2024
OI Wang, Chongyang/0000-0001-8943-7214; Li, Liangchang/0000-0003-1931-6673;
   
FU National Natural Science Foundation of China [81860729, 81970018]; Jilin
   Provincial Basic Research Project of Central Guided Local Science and
   Technology Development Fund [202002020JC]
FX This study was funded by the National Natural Science Foundation of
   China (Nos.: 81860729, 81970018) Jilin Provincial Basic Research Project
   of Central Guided Local Science and Technology Development Fund (No.:
   202002020JC).
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NR 38
TC 8
Z9 12
U1 0
U2 19
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1018-2438
EI 1423-0097
J9 INT ARCH ALLERGY IMM
JI Int. Arch. Allergy Immunol.
PD FEB
PY 2022
VL 183
IS 3
BP 326
EP 336
DI 10.1159/000519295
EA OCT 2021
PG 11
WC Allergy; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Allergy; Immunology
GA ZR1VK
UT WOS:000710500900001
PM 34634782
DA 2026-05-27
ER

PT J
AU Zhao, J
   Du, XJ
   Wang, M
   Yang, PY
   Zhang, JM
AF Zhao, Jun
   Du, Xiujuan
   Wang, Meng
   Yang, Peiyao
   Zhang, Juanmei
TI Salidroside mitigates hydrogen peroxide-induced injury by enhancement of
   microRNA-27a in human trabecular meshwork cells
SO ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY
LA English
DT Article
DE Glaucoma; Salidroside; hydrogen peroxide; microRNA-27a; PI3K; AKT;
   Wnt-beta-catenin
ID STRESS-INDUCED APOPTOSIS; CHRONIC OXIDATIVE STRESS; IN-VITRO; PROTECTS;
   ANTIOXIDANT; ACTIVATION; EXPRESSION; PREVENTS; PI3K/AKT; INCREASE
AB Salidroside (Sal) exerted widely pharmacological effects in multitudinous diseases had been certified. The actual study clarified the protective activity of Sal in H2O2-injured human trabecular meshwork (HTM) cells. HTM cells were disposed with H2O2 to construct an oxidative damage model in vitro. Then, Sal was utilized to administrate HTM cells, and cell viability, apoptosis, apoptosis-interrelated proteins and ROS production were appraised using CCK-8, flow cytometry, western blot and DCFH-DA staining. MiR-27a inhibitor and its control were transfected into HTM cells, and the influences of miR-27a inhibition in HTM cells stimulated with H2O2 and Sal were detected. PI3K/AKT and Wnt/-catenin pathways were ultimately investigated to uncover the underlying mechanism. We found that H2O2 evoked HTM cells oxidative damage, as evidenced by repressing cell viability, inducing apoptosis, activating cleaved-caspase-3/-9 expression and increasing ROS production. Sal significantly lightened H2O2-evoked oxidative damage in HTM cells. Additionally, miR-27a was up-regulated by Sal, and miR-27a suppression significantly reversed the protective effect of Sal on H2O2-injured HTM cells. Finally, Sal activated PI3K/AKT and Wnt/-catenin pathways through enhancement of miR-27a in H2O2-injured HTM cells. In conclusion, these discoveries suggested that Sal could protect HTM cells against H2O2-evoked oxidative damage by activating PI3K/AKT and Wnt/-catenin pathways through enhancement of miR-27a.
   Highlights
   1. H2O2 evokes HTM cells oxidative damage;
   2. Sal relieves H2O2-induced oxidative damage in HTM cells;
   3. Sal enhances miR-27a expression in H2O2-injured HTM cells;
   3. Repressed miR-27a reverses the protective impacts of Sal on H2O2-injured HTM cells;
   4. Sal activates PI3K/AKT and Wnt/-catenin pathways by increasing miR-27a.
C1 [Zhao, Jun; Wang, Meng; Zhang, Juanmei] Linyi Peoples Hosp, Dept Ophthalmol, 27 East Part Jiefang Rd, Linyi 276000, Shandong, Peoples R China.
   [Du, Xiujuan] Shandong Univ TCM, Affiliated Eye Hosp, Eye Inst Shandong Univ Tradit Chinese Med, Dept Ophthalmol, Jinan, Shandong, Peoples R China.
   [Yang, Peiyao] Qingdao Univ, Qingdao, Shandong, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Qingdao University
RP Zhang, JM (corresponding author), Linyi Peoples Hosp, Dept Ophthalmol, 27 East Part Jiefang Rd, Linyi 276000, Shandong, Peoples R China.
EM juanmeizhang0130@sina.com
OI Weeks, Jason/0000-0001-5537-6927
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NR 43
TC 25
Z9 25
U1 0
U2 29
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 2169-1401
EI 2169-141X
J9 ARTIF CELL NANOMED B
JI Artif. Cell. Nanomed. Biotechnol.
PY 2019
VL 47
IS 1
BP 1758
EP 1765
DI 10.1080/21691401.2019.1608222
PG 8
WC Biotechnology & Applied Microbiology; Engineering, Biomedical; Materials
   Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology; Engineering; Materials Science
GA HX1CP
UT WOS:000467127300001
PM 31062616
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, L
   Liu, P
   Feng, X
   Ma, CH
AF Chen, Lvyi
   Liu, Peng
   Feng, Xin
   Ma, Chunhua
TI Salidroside suppressing LPS-induced myocardial injury by inhibiting
   ROS-mediated PI3K/Akt/mTOR pathway in vitro and in vivo
SO JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
LA English
DT Article
DE salidroside; LPS; myocardial injury; ROS; H9C2; PI3K/Akt/mTOR
ID ACUTE LUNG INJURY; TANSHINONE IIA SULFONATE; ISCHEMIA REPERFUSION
   INJURY; KAPPA-B PATHWAY; PHOSPHATIDYLINOSITOL 3-KINASE; NLRP3
   INFLAMMASOME; MITOCHONDRIAL ROS; SIGNALING PATHWAY; OXIDATIVE STRESS;
   RATS
AB The purpose of the present study was to investigate the effect of salidroside (Sal) on myocardial injury in lipopolysaccharide (LPS)-induced endotoxemic in vitro and in vivo. SD rats were randomly divided into five groups: control group, LPS group (15 mg/kg), LPS plus dexamethasone (2 mg/kg), LPS plus Sal groups with different Sal doses (20, 40 mg/kg). Hemodynamic measurement and haematoxylin and eosin staining were performed. Serum levels of creatine kinase (CK), lactate dehydrogenase, the activities of the antioxidant enzymes catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-px), glutathione, tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-1 beta (IL-1 beta) were measured after the rats were killed. iNOS, COX-2, NF-kappa B and PI3K/Akt/mTOR pathway proteins were detected by Western blot. In vitro, we evaluated the protective effect of Sal on rat embryonic heart-derived myogenic cell line H9c2 induced by LPS. Reactive oxygen species (ROS) in H9c2 cells was measured by flow cytometry, and the activities of the antioxidant enzymes CAT, SOD, GSH-px, glutathione-S-transferase, TNF-alpha, IL-6 and IL-1 beta in cellular supernatant were measured. PI3K/Akt/mTOR signalling was examined by Western blot. As a result, Sal significantly attenuated the above indices. In addition, Sal exerts pronounced cardioprotective effect in rats subjected to LPS possibly through inhibiting the iNOS, COX-2, NF-kappa B and PI3K/Akt/mTOR pathway in vivo. Furthermore, the pharmacological effect of Sal associated with the ROS-mediated PI3K/Akt/mTOR pathway was proved by the use of ROS scavenger, N-acetyl-l-cysteine, in LPS-stimulated H9C2 cells. Our results indicated that Sal could be a potential therapeutic agent for the treatment of cardiovascular disease.
C1 [Chen, Lvyi; Liu, Peng] South Cent Univ Nationalities, Sch Pharm, Wuhan, Hubei, Peoples R China.
   [Feng, Xin] China Tibetol Res Ctr, Inst Tibetan Med, Beijing, Peoples R China.
   [Ma, Chunhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Jiangsu, Peoples R China.
C3 South Central Minzu University; China Pharmaceutical University
RP Chen, L (corresponding author), South Cent Univ Nationalities, Sch Pharm, Wuhan, Hubei, Peoples R China.; Ma, CH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Jiangsu, Peoples R China.
EM clyhappy05@163.com; machunhuabest@126.com
RI Chen, Lvyi/ACS-9198-2022; Ma, Chunhua/NFS-9026-2025
FU Hubei Province Natural Science Foundation [2016CFB617]; Applied Basic
   Research Foundation of Wuhan City [2016060101010035]
FX The study was supported by Hubei Province Natural Science Foundation
   (2016CFB617), the Applied Basic Research Foundation of Wuhan City
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NR 47
TC 247
Z9 278
U1 1
U2 54
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
EI 1582-4934
J9 J CELL MOL MED
JI J. Cell. Mol. Med.
PD DEC
PY 2017
VL 21
IS 12
BP 3178
EP 3189
DI 10.1111/jcmm.12871
PG 12
WC Cell Biology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Research & Experimental Medicine
GA FQ7WP
UT WOS:000418574500005
PM 28905500
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Guo, CC
   Li, Y
   Zhang, R
   Zhang, YQ
   Zhao, JY
   Yao, JM
   Sun, J
   Dong, JJ
   Liao, L
AF Guo, Congcong
   Li, Yun
   Zhang, Rui
   Zhang, Yaqin
   Zhao, Junyu
   Yao, Jinming
   Sun, Jie
   Dong, Jianjun
   Liao, Lin
TI Protective Effect of Salidroside Against Diabetic Kidney Disease Through
   Inhibiting BIM-Mediated Apoptosis of Proximal Renal Tubular Cells in
   Rats
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE diabetic kidney disease; salidroside; apoptosis; BIM protein; proximal
   renal tubular epithelial cell
ID INDUCED OXIDATIVE STRESS; GELATINASE-ASSOCIATED LIPOCALIN;
   ISCHEMIA-REPERFUSION INJURY; PROTEIN INTERACTION NETWORK;
   EPITHELIAL-CELLS; THERAPEUTIC TARGET; BH3-ONLY PROTEIN; WEB SERVER;
   ACTIVATION; NEPHROPATHY
AB Background: Accumulating evidences indicate that the apoptosis of proximal tubular epithelial cells (PTECs) play a vital role in the progression of the diabetic kidney disease (DKD). This study aimed to explore the therapeutic potential of salidroside (SAL) in DKD and its underlying mechanism in anti-apoptosis of PTECs.
   Methods: Twenty-eight male Wistar rats were allocated into four groups: sham-operated, uninephrectomy (unx), diabetes with uninephrectomy (DKD) and DKD treated with SAL (DKD + SAL). SAL (70 mg/kg) was gavage administered for 8 weeks. 24-h albuminuria and serum creatinine (SCr), blood urea nitrogen (BUN), renal histological changes were examined. The silico analysis was used to identify the main therapeutic targets and pathways of SAL involved in DKD treatment. Apoptosis was determined by TUNEL and Annexin V-FITC/PI double staining in vivo and in vitro, respectively. The expression of BIM, BAX, and cleaved caspase-3 were evaluated by western blot and immunostaining.
   Results: Treatment with SAL significantly attenuated diabetic kidney injury via inhibiting 24-h albuminuria, SCr, BUN, glomerular mesangial dilatation and tubular injury in DKD rats. The silico analysis identified the intrinsic apoptotic pathway as an important pathway responsible for the nephroprotective properties of SAL. Our data validated that SAL effectively inhibited the apoptosis of PTECs induced by high-glucose (HG), both in vitro and in vivo. Silence of BIM by shRNA in HK-2 cells prevented HG-induced apoptosis. The up-regulated BIM and its downstream targets (BAX and cleaved caspase-3) were also inhibited by SAL.
   Conclusion: In summary, SAL significantly relieved DKD. And the possible mechanisms might be partially attributed to inhibiting apoptosis of proximal renal tubular cells. The apoptotic protein BIM could be an important target of SAL in this process.
C1 [Guo, Congcong; Sun, Jie] Shandong Univ Tradit Chinese Med, Clin Med Coll 1, Jinan, Shandong, Peoples R China.
   [Guo, Congcong; Zhang, Rui; Zhang, Yaqin; Zhao, Junyu; Yao, Jinming; Liao, Lin] Shandong Univ, Shandong Prov QianFoShan Hosp, Dept Internal Med, Div Endocrinol, Jinan, Shandong, Peoples R China.
   [Li, Yun] Shandong Univ, Shandong Prov Hosp, Dept Gen Hlth Care 2, Jinan, Shandong, Peoples R China.
   [Dong, Jianjun] Shandong Univ, Qilu Hosp, Dept Internal Med, Div Endocrinol, Jinan, Shandong, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong First
   Medical University & Shandong Academy of Medical Sciences; Shandong
   University; Shandong First Medical University & Shandong Academy of
   Medical Sciences; Shandong University; Shandong University
RP Liao, L (corresponding author), Shandong Univ, Shandong Prov QianFoShan Hosp, Dept Internal Med, Div Endocrinol, Jinan, Shandong, Peoples R China.; Dong, JJ (corresponding author), Shandong Univ, Qilu Hosp, Dept Internal Med, Div Endocrinol, Jinan, Shandong, Peoples R China.
EM dongjianjun@sdu.edu.cn; liaolin@sdu.edu.cn
RI Zhang, Rui/AAX-6912-2020
FU National Natural Science Foundation of China [81670757, 81770822,
   81570742]; Grant for development of science and technology of Shandong
   Traditional Chinese Medicine [2017-172]; Grant for Shandong Provincial
   Natural Science Foundation [ZR2016HQ26]; Grant for the development of
   science and technology of Jinan City [201602172]
FX This work was funded by National Natural Science Foundation of China
   (81670757, 81770822, and 81570742), Grant for development of science and
   technology of Shandong Traditional Chinese Medicine (No. 2017-172),
   Grant for Shandong Provincial Natural Science Foundation (ZR2016HQ26),
   and Grant for the development of science and technology of Jinan City
   (201602172).
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NR 70
TC 33
Z9 36
U1 0
U2 21
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD DEC 4
PY 2018
VL 9
AR 1433
DI 10.3389/fphar.2018.01433
PG 16
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HC8LX
UT WOS:000452055600003
PM 30564128
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zdanowski, R
   Skopinska-Rózewska, E
   Wilczak, J
   Borecka, A
   Lewicka, A
   Lewicki, S
AF Zdanowski, Robert
   Skopinska-Rozewska, Ewa
   Wilczak, Jacek
   Borecka, Anna
   Lewicka, Aneta
   Lewicki, Slawomir
TI Different effects of feeding pregnant and lactating mice Rhodiola
   kirilowii aqueous and hydro-alcoholic extracts on their serum
   angiogenic activity and content of selected polyphenois
SO CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY
LA English
DT Article
DE mice; pregnancy; Rhodiola kirilowii; polyphenols; angiogenesis
ID TUMOR-INDUCED ANGIOGENESIS; METABOLIC-ACTIVITY; CELLULAR-IMMUNITY; ROSEA
   EXTRACTS; CELLS; RATS; PROLIFERATION; GRANULOCYTES; SALIDROSIDE; NUMBER
AB Angiogenesis plays an important role in many physiological processes, among them the formation of tissues and organs during embiyogenesis. A lot of medicinal plants exhibit angiomodulatory properties. This creates the need for a thorough check of whether the plant extracts that we would like to give to pregnant women in order to increase their resistance to bacterial or viral infection will have negative effects on angiogenesis, and consequently on fetal development. This paper seeks to investigate the effect of serum of pregnant and nursing Balb/c mice that received aqueous (RKW) or hydro-alcoholic (RKW-A) R. kirilowii extracts (20 mg/kg), or epigallocatechin (0.2 mg/kg), on the in vitro proliferation and migration of mouse endothelial cell line HECa10. Of the 15 identified polyphenols in the extracts by HPLC, 8 were present in the sera. Chemical analysis revealed higher salidroside, kaempferol, chlorogenic acid, bFGF and VEGF concentration in RKW-A sera than in the sera of RKW group of mice. RKW-A and EGC sera did not affect migration of endothelial cells, however we noted some increase of migrating cells after RKW-sera treatment. RKW and EGC sera did not affect proliferation of endothelial cells. Sera of mothers from RKW-A group impaired the proliferation of endothelial cells in comparison to other groups. These data allow us to assume that Rhodiola kirilowii hydro-alcoholic extract (RKW-A) is potentially able to modulate pre- and post- natal angiogenesis what might influence the development of organs in progeny. Sera of RKW mothers have not harm the proliferation of endothelial cells, despite they also contain antiangiogenic catechins and salidroside. This suggests the existence in RKW-A extract and in RKW-A sera of some other, as yet unidentified substances influencing endothelial cells proliferation.
C1 [Zdanowski, Robert; Lewicki, Slawomir] Mil Inst Hyg & Epidemiol, Dept Regenerat Med & Cell Biol, Kozielska 4, PL-01163 Warsaw, Poland.
   [Skopinska-Rozewska, Ewa] Mil Inst Hyg & Epidemiol, Dept Microwave Safety, Warsaw, Poland.
   [Skopinska-Rozewska, Ewa] Warsaw Med Univ, Pathomorphol Dept, Ctr Biostruct Res, Warsaw, Poland.
   [Wilczak, Jacek] Warsaw Univ Life Sci, Dept Physiol Sci, Fac Vet Med, Warsaw, Poland.
   [Borecka, Anna] Mil Inst Hyg & Epidemiol, Lab Parasitol, Warsaw, Poland.
   [Lewicka, Aneta] Mil Inst Hyg & Epidemiol, Lab Food & Nutr Hyg, Warsaw, Poland.
C3 Military Institute of Hygiene & Epidemiology (MIHE); Military Institute
   of Hygiene & Epidemiology (MIHE); Medical University of Warsaw; Warsaw
   University of Life Sciences; Military Institute of Hygiene &
   Epidemiology (MIHE); Military Institute of Hygiene & Epidemiology (MIHE)
RP Lewicki, S (corresponding author), Mil Inst Hyg & Epidemiol, Dept Regenerat Med & Cell Biol, Kozielska 4, PL-01163 Warsaw, Poland.
EM lewickis@gmail.com
RI ; Lewicki, Sławomir/AAZ-4709-2020; Borecka, Anna/K-1757-2015
OI Wilczak, Jacek/0000-0002-3053-3663; Lewicki,
   Sławomir/0000-0002-0539-0680; Lewicka, Aneta/0000-0002-9026-0759;
   Zdanowski, Robert/0000-0003-0455-1072; Borecka, Anna/0000-0002-3303-1634
FU National Centre of Science (Krakow, Poland) [2012/05/B/NZ7/03219]
FX The present study was supported by the National Centre of Science
   (Krakow, Poland; grant no. 2012/05/B/NZ7/03219).
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NR 25
TC 4
Z9 4
U1 0
U2 8
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1426-3912
EI 1644-4124
J9 CENT EUR J IMMUNOL
JI Central Eur. J. Immunol.
PY 2017
VL 42
IS 1
BP 17
EP 23
DI 10.5114/ceji.2017.67314
PG 7
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA EV2QY
UT WOS:000401601400003
PM 28680327
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Shen, J
   Chen, SS
   Li, X
   Wu, LL
   Mao, X
   Jiang, JJ
   Zhu, DB
AF Shen, Jun
   Chen, Shasha
   Li, Xin
   Wu, Lele
   Mao, Xue
   Jiang, Jingjie
   Zhu, Dabu
TI Salidroside Mediated the Nrf2/GPX4 Pathway to Attenuates Ferroptosis in
   Parkinson's Disease
SO NEUROCHEMICAL RESEARCH
LA English
DT Article
DE Salidroside; Nrf2/GPX4; Ferroptosis; Parkinson's disease
ID ERASTIN-INDUCED FERROPTOSIS; ALPHA-SYNUCLEIN; EXPRESSION; IRON
AB Parkinson's Disease (PD) is characterized by the loss of dopaminergic neurons, with ferroptosis playing a significant role. Salidroside (SAL) has shown neuroprotective potential, this study aims to explore its capacity to mitigate ferroptosis in PD, focusing on the modulation of the Nuclear Factor E2-Related Factor 2 (Nrf2)/ Glutathione Peroxidase 4 (GPX4) pathway. Male C57BL/6 mice were subjected to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) to induce PD-like symptoms, followed by SAL and Nrf2 inhibitor administration. Then behavioral tests, immunohistochemical staining, transmission electron microscopy, and Western blot analysis were conducted to assess motor functions, pathological changes, ferroptosis, and related protein expressions. In vitro, SH-SY5Y cells were treated with erastin to induce ferroptosis to assess the protective effects of SAL. Additionally, A53T-alpha-synuclein (alpha-syn) was used to stimulate the PD model, SAL and a Nrf2 inhibitor (ML385) was utilized to elucidate the role of the Nrf2/GPX4 pathway in mitigating ferroptosis in PD. In vivo, SAL significantly improved motor functions and reduced the expression of alpha-syn, while increasing tyrosine hydroxylase (TH) expression of PD mice. Additionally, SAL treatment notably enhanced the levels of antioxidants and reduced MDA and iron content in the substantia nigra of PD mice. In vitro, SAL treatment increased the TH, GPX4, Nrf2 expression, and mitochondrial membrane potential whereas alleviated ferroptosis through the Nrf2/GPX4 pathway, as evidenced in erastin-induced and alpha-syn overexpressing SH-SY5Y cells. While these effects were reversed upon Nrf2 inhibition. SAL demonstrates significant potential in mitigating PD pathology and ferroptosis, positioning the Nrf2/GPX4 pathway as a promising therapeutic target. However, future studies should focus on the long-term effects of SAL, its pharmacokinetics, addressing the multifactorial nature of PD pathogenesis.
C1 [Shen, Jun; Li, Xin; Wu, Lele; Mao, Xue; Jiang, Jingjie] Hangzhou Linping Dist First Peoples Hosp, Dept Gen Med, 369 Yingbin Rd,Nanyuan St, Hangzhou 311199, Zhejiang, Peoples R China.
   [Chen, Shasha] Zhejiang Univ, Affiliated Hosp 2, Dept Med Geriatr, Sch Med, Hangzhou 310009, Zhejiang, Peoples R China.
   [Zhu, Dabu] Hangzhou Linping Dist First Peoples Hosp, Dept Pharm, Hangzhou 311199, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Shen, J (corresponding author), Hangzhou Linping Dist First Peoples Hosp, Dept Gen Med, 369 Yingbin Rd,Nanyuan St, Hangzhou 311199, Zhejiang, Peoples R China.
EM shenjunlinping@163.com
RI Zhu, Dabu/ABG-2960-2021
OI 李, 鑫/0009-0003-9255-8641
FU The Medical and Health Technology Project of Linping District
FX Not applicable.
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NR 50
TC 32
Z9 38
U1 3
U2 57
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD MAY
PY 2024
VL 49
IS 5
BP 1291
EP 1305
DI 10.1007/s11064-024-04116-w
EA FEB 2024
PG 15
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA MZ2B0
UT WOS:001171415400001
PM 38424396
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Ye, QN
   Zhou, Y
   Zhao, CQ
   Xu, LM
   Ping, J
AF Ye, Qiannan
   Zhou, Yang
   Zhao, Changqing
   Xu, Lieming
   Ping, Jian
TI Salidroside Inhibits CCl4-Induced Liver Fibrosis in Mice by
   Reducing Activation and Migration of HSC Induced by Liver Sinusoidal
   Endothelial Cell-Derived Exosomal SphK1
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; liver fibrosis; SphK; S1P; S1PRs; exosomes; liver
   sinusoidal endothelial cells; hepatic stellate cell
ID HEPATIC STELLATE CELLS; SPHINGOSINE KINASE-1; MOUSE-LIVER; INFLAMMATION;
   PROTECTS; INJURY; DEATH; APOPTOSIS; CASPASES; S1P
AB Sphingosine kinase 1 (SphK1)/Sphingosine-1-phosphate (S1P)/S1PRs signaling pathway is known to involve the advancement of liver fibrosis. Exosomal SphK1 promotes hepatic stellate cells (HSC) migration. Salidroside (Sal) inhibits liver fibrosis, but its mechanism is yet to be elucidated. This study was to explore the influences of Sal on the SphK/S1P/S1PRs signaling pathway in liver fibrosis induced by carbon tetrachloride (CCl4) in vivo, and investigated the mechanism of Sal affecting the migration and activation of HSC triggered by exosomal SphK1 in vitro. Our data showed that Sal reduced the activities of alanine transaminase (ALT), aspartate aminotransferase (AST) in serum, and hydroxyproline (Hyp) content in the liver tissue. Sal subdued the expression of alpha-smooth muscle actin (alpha-SMA), fibronectin (FN) and type I collagen (Col I) of the liver. Sal also reduced mitochondria-induced hepatocyte apoptosis and to inhibit JNK activation. Furthermore, Sal remarkably eradicated the influence of SphK1, SphK2, S1P, and S1PRs triggered by CCl4, whether stimulating or hindering. Compared with serum-derived exosomes from model group mice, serum-derived exosomes from Sal group mice expressed lower SphK1 and reduced JS 1 (mouse HSC cell line) migration. In addition, Sal was also observed to subdue Col I expression, AKT activation, and LX-2 migration induced by exosomal SphK1 from SK-HEP-1 (a kind of liver sinusoidal endothelial cells (LSEC) cell line). In conclusion, Sal could effectively alleviate liver injury, hepatocyte apoptosis, and liver fibrosis in vivo, providing supports that the protective effects of Sal might be realized by suppressing JNK activation and modulating the SphK/S1P/S1PRs axis. In vitro, it was observed that Sal might alleviate LX-2 migration and activation induced by exosomal SphK1 by inhibiting the AKT activation.
C1 [Ye, Qiannan; Zhao, Changqing; Xu, Lieming; Ping, Jian] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai, Peoples R China.
   [Ye, Qiannan; Zhao, Changqing; Xu, Lieming] Shanghai Univ Tradit Chinese Med, Inst Liver Dis, Shanghai, Peoples R China.
   [Zhou, Yang] Shanghai Univ Tradit Chinese Med, Yueyang Hosp, Shanghai, Peoples R China.
   [Xu, Lieming] Shanghai Key Lab Tradit Chinese Med, Shanghai, Peoples R China.
   [Xu, Lieming; Ping, Jian] Minist Educ, Key Lab Liver & Kidney Dis, Shanghai, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine; Shanghai University
   of Traditional Chinese Medicine; Shanghai University of Traditional
   Chinese Medicine
RP Xu, LM; Ping, J (corresponding author), Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai, Peoples R China.; Xu, LM (corresponding author), Shanghai Univ Tradit Chinese Med, Inst Liver Dis, Shanghai, Peoples R China.; Xu, LM (corresponding author), Shanghai Key Lab Tradit Chinese Med, Shanghai, Peoples R China.; Xu, LM; Ping, J (corresponding author), Minist Educ, Key Lab Liver & Kidney Dis, Shanghai, Peoples R China.
EM xulieming@shutcm.edu.cn; pingjian@aliyun.com
FU National Natural Science Foundation of China [81773980]
FX This work was supported by grants from the National Natural Science
   Foundation of China (No. 81773980).
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NR 43
TC 39
Z9 43
U1 7
U2 52
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD MAY 13
PY 2021
VL 12
AR 677810
DI 10.3389/fphar.2021.677810
PG 14
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA SI6XI
UT WOS:000654970700001
PM 34054552
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, MH
   Zhang, JZ
   Liu, WG
   Wang, WJ
AF Liu, Meihan
   Zhang, Jingzhe
   Liu, Wanguo
   Wang, Wenjun
TI RETRACTED: Salidroside protects ATDC5 cells against
   lipopolysaccharide-induced injury through up-regulation of microRNA-145
   in osteoarthritis (Retracted article. See vol. 95, 2021)
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article; Retracted Publication
DE Salidroside; Lipopolysaccharide; microRNA-145; NF-kappa B; p38MAPK
ID SELECTIVE COX-2 INHIBITION; NF-KAPPA-B; ARTICULAR-CARTILAGE; IN-VITRO;
   DIFFERENTIATION; PROLIFERATION; CHONDROCYTES; INFLAMMATION; DEGRADATION;
   ACTIVATION
AB Background: Osteoarthritis (OA) is a kind of degenerative disease characterized by the degeneration of the articular cartilage. Salidroside (SAL) is an active component of Rhodiola rosea L., which exhibits diverse pharmacological effects in different diseases. However, the effects of SAL on OA remain largely unclear. The study aimed to investigate the roles of SAL in lipopolysaccharides (LPS)-induced inflammatory injury in murine ATDC5 chondrocyte cells.
   Methods: LPS induced ATDC5 cell injury model was constructed by determining cell viability, apoptosis, apoptosis-associated factors as well as inflammatory cytokines expressions and concentrations. Then, the various concentrations of SAL were used to treat ATDC5 cells, and the effect of SAL on LPS-induce inflammatory injury was detected. After treatment with SAL, the expression level of miR-145 was measured by qRT-PCR. Subsequently, miR-145 inhibitor and corresponding control were transfected into ATDC5 cells to explore the influences of miR-145 in LPS-induce inflammatory injury. Besides, the key signaling pathways of NF-kappa B and p38MAPK were analyzed by using western blot.
   Results: LPS inhibited cell viability, induced apoptosis, activated cleaved-caspase-3/-9 expression, as well as increased IL-6, MCP-1 and TNF-alpha expressions and secretions in ATDC5 cells. SAL significantly alleviated LPS-induced inflammatory injury. Meanwhile, the expression of miR-145 was up-regulated by SAL. The protective effect of SAL on LPS-induced injury was obviously reversed by miR-145 inhibition. Furthermore, SAL inactivated NF-kappa B and p38MAPK signaling pathways by regulating miR-145.
   Conclusions: These findings suggested that SAL could protect ATDC5 cells against LPS-induced injury via up regulation of miR-145 in ATDC5 chondrocyte cells.
C1 [Liu, Meihan] Jilin Univ, China Japan Union Hosp, Dept Ultrasonog, Changchun 130033, Jilin, Peoples R China.
   [Zhang, Jingzhe; Liu, Wanguo; Wang, Wenjun] Jilin Univ, China Japan Union Hosp, Dept Orthoped, 126 Xiantai St, Changchun 130033, Jilin, Peoples R China.
C3 Jilin University; Jilin University
RP Wang, WJ (corresponding author), Jilin Univ, China Japan Union Hosp, Dept Orthoped, 126 Xiantai St, Changchun 130033, Jilin, Peoples R China.
EM wangwenjun0053@sina.com
RI Wang, Wenjun/GPP-3970-2022
CR [Anonymous], EVID BASED COMPLEMEN
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NR 57
TC 14
Z9 16
U1 0
U2 15
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD FEB
PY 2019
VL 67
BP 441
EP 448
DI 10.1016/j.intimp.2018.12.041
PG 8
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA HK1IY
UT WOS:000457659700048
PM 30586667
DA 2026-05-27
ER

PT J
AU Sun, L
   Li, XF
   Zhang, J
   Pei, JC
   Zhang, JH
   Wang, YH
   Lin, F
   Zhao, GA
AF Sun, Li
   Li, Xuefang
   Zhang, Jie
   Pei, Jiachao
   Zhang, Jianhua
   Wang, Yinghua
   Lin, Fei
   Zhao, Guoan
TI SAL protects endothelial cells from H2O2-induced
   endothelial dysfunction: Regulation of inflammation and autophagy by
   EZH2
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Salidroside; HUVEC cells; EZH2; Endothelial dysfunction; Inflammation;
   Autophagy
AB One component of the polycomb repressor complex 2 is histone methyltransferase zeste homolog 2 (EZH2), which is also called Enhancer of zeste homolog 2. It is considered a potential therapeutic target for inhibiting endothelial dysfunction.. Hence, directing efforts towards EZH2 to weaken endothelium damage and regulate vascular lesions proves to be a highly successful therapeutic approach for enhancing endothelial dysfunction. This study aimed to investigate the mechanism by which salidroside (SAL) improves hydrogen peroxide (H2O2)-induced endothelial dysfunction. The investigation involved the use of many techniques, including western blotting, real-time polymerase chain reaction (RT-PCR), a scratch test, molecular docking, and other methods. The experimental findings demonstrated that SAL has the ability to inhibit the impaired functioning of endothelial cells caused by H2O2 and decrease the levels of NF-kappa B p65, NLRP3, TNF-alpha, Beclin1, LC3, and P62 proteins. Additionally, there seems to be a targeting relationship between SAL and EZH2, and EZH2 knockdown can reproduce the protective effect of SAL on endothelial function. Overall, SAL inhibits H2O2-induced HUVEC dysfunction by regulating autophagy and inflammatory signaling pathways through EZH2.
C1 [Sun, Li; Li, Xuefang; Zhang, Jie; Pei, Jiachao; Lin, Fei; Zhao, Guoan] Xinxiang Med Univ, Cardiovasc Res Ctr, Affiliated Hosp 1, Xinxiang 453100, Henan, Peoples R China.
   [Sun, Li; Zhang, Jianhua; Wang, Yinghua] Zhengzhou Sino Crystal Diamond Co Ltd, Zhengzhou 450001, Henan, Peoples R China.
C3 Henan Medical University
RP Lin, F; Zhao, GA (corresponding author), Xinxiang Med Univ, Cardiovasc Res Ctr, Affiliated Hosp 1, Xinxiang 453100, Henan, Peoples R China.
EM sun3155278149@126.com; 1fy2018117@xxmu.edu.cn; zhangjie1998825@163.com;
   peijiachao2024@163.com; wayne73@126.com; yinghuawang111@163.com;
   1fy2015157@xxmu.edu.cn; guoanzhao@xxmu.edu.cn
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NR 55
TC 6
Z9 8
U1 0
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD DEC 5
PY 2024
VL 142
AR 113060
DI 10.1016/j.intimp.2024.113060
EA SEP 2024
PN B
PG 18
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA H6P1G
UT WOS:001324631000001
PM 39321703
OA hybrid
DA 2026-05-27
ER

PT J
AU Zeng, Q
   Nie, X
   Li, L
   Liu, HF
   Peng, YY
   Zhou, WT
   Hu, XJ
   Xu, XY
   Chen, XL
AF Zeng, Qi
   Nie, Xu
   Li, Li
   Liu, Hui-Fang
   Peng, Yang-Yao
   Zhou, Wang-Ting
   Hu, Xiao-Jia
   Xu, Xin-Yi
   Chen, Xue-Li
TI Salidroside Promotes Sensitization to Doxorubicin in Human Cancer Cells
   by Affecting the PI3K/Akt/HIF Signal Pathway and Inhibiting the
   Expression of Tumor-Resistance-Related Proteins
SO JOURNAL OF NATURAL PRODUCTS
LA English
DT Article
ID ENHANCES CYTOTOXICITY; DRUG-RESISTANCE; HYPOXIA; CYCLE
AB Salidroside (Sal), the major active constituent of Rhodiola rosea L., is considered as a potential pro-drug with various activities; however, its role in tumor therapy is not clear. Here, we demonstrated in vitro and in vivo that Sal enhanced the inhibitory activity of doxorubicin (DOX) in drug-resistant cancer cell lines. Our results showed that combination drug treatment (Sal and DOX) significantly decreased cell proliferation, migration, and motility. Besides biological validation, a luciferase-labeled animal tumor xenograft model and bioluminescence imaging (BLI) were applied for assessing the tumor progression. Sal combined with DOX inhibited the growth of HeLa-ADR-luc cells in vivo and downregulated the DOX-induced high expression of MDR1. Also, Sal downregulated the Bcl-2, MMP-2, MMP-9, PI3K, and AKT and upregulated BAX proteins. Sal demonstrated high safety and cardiac protection activity. We discovered that Sal enhances DOX sensitivity through the regulation of PI3K/Akt/HIF-1a and DOX-induced resistance pathways. Our results suggest that Sal could be a novel chemosensitization agent for the treatment of multi-drug-resistance tumors.
C1 [Zeng, Qi; Nie, Xu; Li, Li; Liu, Hui-Fang; Peng, Yang-Yao; Zhou, Wang-Ting; Xu, Xin-Yi; Chen, Xue-Li] Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Sch Life Sci & Technol, Xian 710071, Peoples R China.
   [Zeng, Qi; Nie, Xu; Li, Li; Liu, Hui-Fang; Peng, Yang-Yao; Zhou, Wang-Ting; Xu, Xin-Yi; Chen, Xue-Li] Xidian Univ, Xian Key Lab Intelligent Sensing & Regulat Trans, Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China.
   [Hu, Xiao-Jia] Nat Sunshine Shanghai Prod Inc, Shanghai 200040, Peoples R China.
C3 Xidian University; Xidian University
RP Xu, XY; Chen, XL (corresponding author), Xidian Univ, Engn Res Ctr Mol & Neuro Imaging, Minist Educ, Sch Life Sci & Technol, Xian 710071, Peoples R China.; Xu, XY; Chen, XL (corresponding author), Xidian Univ, Xian Key Lab Intelligent Sensing & Regulat Trans, Sch Life Sci & Technol, Xian 710126, Shaanxi, Peoples R China.
EM xyxu@xidian.edu.cn; xlchen@xidian.edu.cn
RI ; Zeng, Qi/A-2628-2016; Chen, Xueli/T-9706-2019; Zhou,
   Wangting/NRY-0316-2025
OI Xu, Xinyi/0000-0001-6867-7307; Zeng, Qi/0000-0002-3563-0569; 
FU National Key R&D Program of China [2018YFC0910600]; Key Research and
   Development Program of Shaanxi [2021ZDLSF04-05]; National Young
   Top-notch Talent of "Ten Thousand Talents Program"; National Natural
   Science Foundation of China [81871397, 32101115, 62105255]; Shaanxi
   Science Fund for Distinguished Young Scholars [2020JC-27]; Fundamental
   Research Funds for the Central Universities [JB211207, QTZX2105,
   QTZX2185]; Shaanxi Young Top-notch Talent of "Special Support Program"
FX This work was supported in part by the National Key R&D Program of China
   under Grant No. 2018YFC0910600, Key Research and Development Program of
   Shaanxi under Grant No. 2021ZDLSF04-05, the National Young Top-notch
   Talent of "Ten Thousand Talents Program", the National Natural Science
   Foundation of China under Grant Nos. 81871397, 32101115, and 62105255,
   the Shaanxi Science Fund for Distinguished Young Scholars under Grant
   No. 2020JC-27, the Shaanxi Young Top-notch Talent of "Special Support
   Program", and the Fundamental Research Funds for the Central
   Universities under Grant Nos. JB211207, QTZX2105, and QTZX2185.
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NR 31
TC 22
Z9 30
U1 6
U2 35
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0163-3864
EI 1520-6025
J9 J NAT PROD
JI J. Nat. Prod.
PD JAN 28
PY 2022
VL 85
IS 1
BP 196
EP 204
DI 10.1021/acs.jnatprod.1c00950
EA JAN 2022
PG 9
WC Plant Sciences; Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy
GA ZP9RL
UT WOS:000740459000001
PM 34978808
DA 2026-05-27
ER

PT J
AU Tang, C
   Zhao, CC
   Yi, H
   Geng, ZJ
   Wu, XY
   Zhang, Y
   Liu, Y
   Fan, G
AF Tang, Ce
   Zhao, Cheng-Cheng
   Yi, Huan
   Geng, Zang-Jia
   Wu, Xin-Yue
   Zhang, Yi
   Liu, Ya
   Fan, Gang
TI Traditional Tibetan Medicine in Cancer Therapy by Targeting Apoptosis
   Pathways
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE cancer; traditional Tibetan medicine; anticancer activity; apoptosis;
   Ophiocordyceps sinensis; salidroside; gallic acid
ID BERBERINE-INDUCED APOPTOSIS; TERMINALIA-CHEBULA RETZ.; CELLS IN-VITRO;
   GALLIC ACID; ELLAGIC ACID; CORDYCEPS-SINENSIS; COLON-CANCER;
   LUNG-CANCER; INHIBITS PROLIFERATION; MITOCHONDRIAL PATHWAY
AB Cancer is a leading cause of death around the world. Apoptosis, one of the pathways of programmed cell death, is a promising target for cancer therapy. Traditional Tibetan medicine (TTM) has been used by Tibetan people for thousands of years, and many TTMs have been proven to be effective in the treatment of cancer. This paper summarized the medicinal plants with anticancer activity in the Tibetan traditional system of medicine by searching for Tibetan medicine monographs and drug standards and reviewing modern research literatures. Forty species were found to be effective in treating cancer. More importantly, some TTMs (e.g.,Ophiocordyceps sinensis,Phyllanthus emblicaL. andRhodiola kirilowii(Regel) Maxim.) and their active ingredients (e.g., cordycepin, salidroside, and gallic acid) have been reported to possess anticancer activity by targeting some apoptosis pathways in cancer, such as Bcl-2/Bax, caspases, PI3K/Akt, JAK2/STAT3, MAPK, and AMPK. These herbs and natural compounds would be potential drug candidates for the treatment of cancer.
C1 [Tang, Ce] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu, Peoples R China.
   [Tang, Ce; Zhang, Yi; Fan, Gang] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu, Peoples R China.
   [Zhao, Cheng-Cheng; Yi, Huan; Wu, Xin-Yue] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu, Peoples R China.
   [Geng, Zang-Jia] Southwest Minzu Univ, Sch Pharm, Chengdu, Peoples R China.
   [Liu, Ya] Hosp Chengdu Univ Tradit Chinese Med, Dept Endocrinol, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine; Southwest Minzu University; Chengdu University of
   Traditional Chinese Medicine
RP Fan, G (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu, Peoples R China.; Liu, Y (corresponding author), Hosp Chengdu Univ Tradit Chinese Med, Dept Endocrinol, Chengdu, Peoples R China.
EM liuyaya918@163.com; fangang1111@163.com
RI Fan, Gang/AGG-2500-2022
FU National Natural Science Foundation of China [81874370, 81903922]; Major
   Cultivation Project of Scientific and Technological Achievements
   Transformation of Sichuan Provincial Department of Education [18CZ0011];
   National Key Research and Development Program of China [2017YFC1703900];
   "Xinglin Scholars" Research Promotion Program of Chengdu University of
   Traditional Chinese Medicine [BSH2019002]
FX The authors gratefully acknowledge the financial support from the
   National Natural Science Foundation of China (Nos. 81874370 and
   81903922), the Major Cultivation Project of Scientific and Technological
   Achievements Transformation of Sichuan Provincial Department of
   Education (No. 18CZ0011), the National Key Research and Development
   Program of China (No. 2017YFC1703900), and "Xinglin Scholars" Research
   Promotion Program of Chengdu University of Traditional Chinese Medicine
   (BSH2019002).
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NR 163
TC 47
Z9 53
U1 6
U2 92
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD JUL 7
PY 2020
VL 11
AR 976
DI 10.3389/fphar.2020.00976
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA MR1VC
UT WOS:000553378400001
PM 32774302
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, ZJ
   Xu, TZ
   Chen, JX
   Shao, ZX
   Wang, K
   Yan, YC
   Wu, CC
   Lin, JL
   Wan, HL
   Gao, WY
   Zhang, XL
   Wang, XY
AF Zhang, Zengjie
   Xu, Tianzhen
   Chen, Jiaoxiang
   Shao, Zhenxuan
   Wang, Ke
   Yan, Yingchao
   Wu, Congcong
   Lin, Jialang
   Wan, Haoli
   Gao, Weiyang
   Zhang, Xiaolei
   Wang, Xiangyang
TI Parkin-mediated mitophagy as a potential therapeutic target for
   intervertebral disc degeneration
SO CELL DEATH & DISEASE
LA English
DT Article
ID NUCLEUS PULPOSUS CELLS; MITOCHONDRIAL DYSFUNCTION; OXIDATIVE STRESS;
   AUTOPHAGIC FLUX; APOPTOSIS; PROTECTS; INJURY; DEATH; ELIMINATION;
   INHIBITION
AB Intervertebral disc degeneration (IDD) is a complicated pathological condition blamed for low back pain. Mitochondrion is of vital importance for cellular homeostasis, and mitochondrial dysfunction is considered to be one of the major causes of cellular damage. Mitophagy is a cellular process to eliminate impaired mitochondria and showed protective effects in various diseases; however, its role in IDD is still not clear. Here, we explore the role of Parkin-mediated mitophagy in IDD. In this study, we found that Parkin was upregulated in degenerative nucleus pulposus (NP) tissues in vivo as well as in TNF-alpha stimulated NP cells in vitro. Knockdown of Parkin by siRNA showed that Parkin is crucial for apoptosis and mitochondrion homeostasis in NP cells. Further study showed that upregulation of Parkin by salidroside may eliminate impaired mitochondria and promote the survival of NP cells through activation of mitophagy in vitro. In in vivo study, we found that salidroside could inhibit the apoptosis of NP cells and ameliorate the progression of IDD. These results suggested that Parkin is involved in the pathogenesis of IDD and may be a potential therapeutic target for IDD.
C1 [Zhang, Zengjie; Xu, Tianzhen; Chen, Jiaoxiang; Shao, Zhenxuan; Wang, Ke; Yan, Yingchao; Wu, Congcong; Lin, Jialang; Wan, Haoli; Gao, Weiyang; Zhang, Xiaolei; Wang, Xiangyang] Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed, West Xueyuan Rd 109, Wenzhou 325027, Zhejiang, Peoples R China.
   [Zhang, Zengjie; Xu, Tianzhen; Chen, Jiaoxiang; Shao, Zhenxuan; Wang, Ke; Yan, Yingchao; Wu, Congcong; Lin, Jialang; Wan, Haoli; Gao, Weiyang; Zhang, Xiaolei; Wang, Xiangyang] Wenzhou Med Univ, Yuying Childrens Hosp, West Xueyuan Rd 109, Wenzhou 325027, Zhejiang, Peoples R China.
   [Zhang, Zengjie; Xu, Tianzhen; Chen, Jiaoxiang; Shao, Zhenxuan; Wang, Ke; Yan, Yingchao; Wu, Congcong; Lin, Jialang; Wan, Haoli; Gao, Weiyang; Zhang, Xiaolei; Wang, Xiangyang] Zhejiang Prov Key Lab Orthopaed, Wenzhou, Zhejiang, Peoples R China.
   [Zhang, Zengjie; Xu, Tianzhen; Chen, Jiaoxiang; Shao, Zhenxuan; Wang, Ke; Yan, Yingchao; Wu, Congcong; Lin, Jialang; Wan, Haoli; Gao, Weiyang; Zhang, Xiaolei; Wang, Xiangyang] Wenzhou Med Univ, Sch Med 2, Wenzhou, Zhejiang, Peoples R China.
   [Xu, Tianzhen] Wenzhou Med Univ, Affiliated Hosp 3, Wansong Rd 108, Ruian, Zhejiang, Peoples R China.
   [Xu, Tianzhen] Wenzhou Med Univ, Ruian Peoples Hosp, Wansong Rd 108, Ruian, Zhejiang, Peoples R China.
   [Zhang, Xiaolei] Chinese Orthopaed Regenerat Med Soc, Ruian, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Wenzhou Medical
   University; Wenzhou Medical University; Wenzhou Medical University
RP Zhang, XL; Wang, XY (corresponding author), Wenzhou Med Univ, Affiliated Hosp 2, Dept Orthopaed, West Xueyuan Rd 109, Wenzhou 325027, Zhejiang, Peoples R China.; Zhang, XL; Wang, XY (corresponding author), Wenzhou Med Univ, Yuying Childrens Hosp, West Xueyuan Rd 109, Wenzhou 325027, Zhejiang, Peoples R China.; Zhang, XL; Wang, XY (corresponding author), Zhejiang Prov Key Lab Orthopaed, Wenzhou, Zhejiang, Peoples R China.; Zhang, XL; Wang, XY (corresponding author), Wenzhou Med Univ, Sch Med 2, Wenzhou, Zhejiang, Peoples R China.
EM zhangxiaolei@wmu.edu.cn; xiangyangwang@wmu.edu.cn
RI ; chen, jiaoxiang/OIT-3223-2025; Zhang, Xiaolei/AFS-0882-2022
OI zhang, zengjie/0000-0002-1760-8827; Zhang, Xiaolei/0000-0003-0117-7599
FU Zhejiang Public service technology research program/social development
   [LGF18H060008]; Zhejiang Provincial Natural Science Foundation of China
   [LY17H060010]; Major scientific and technological project of medical and
   health in Zhejiang Province [WKJ-ZJ1527]
FX This work was supported by grant from the Zhejiang Public service
   technology research program/social development (LGF18H060008), Zhejiang
   Provincial Natural Science Foundation of China (LY17H060010), Major
   scientific and technological project of medical and health in Zhejiang
   Province (WKJ-ZJ1527).
CR [Anonymous], AUTOPHAGY
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NR 50
TC 92
Z9 103
U1 0
U2 9
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 2041-4889
J9 CELL DEATH DIS
JI Cell Death Dis.
PD SEP 24
PY 2018
VL 9
AR 980
DI 10.1038/s41419-018-1024-9
PG 16
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA GV6YO
UT WOS:000446267200010
PM 30250268
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, J
   Liu, WQ
   Wang, YF
   Liu, AQ
   Yu, SX
   Yu, HD
   Zuo, ZF
   Liu, XZ
AF Li, Jing
   Liu, Wenqiang
   Wang, Yufei
   Liu, Anqi
   Yu, Shengxue
   Yu, Hongdan
   Zuo, Zhongfu
   Liu, Xuezheng
TI Salidroside Inhibits Ganglion Cell Apoptosis by Suppressing the Muller
   Cell Inflammatory Response in Diabetic Retinopathy
SO CURRENT EYE RESEARCH
LA English
DT Article
DE Diabetic retinopathy; Muller cells; retinal ganglion cells; IL-22;
   salidroside
AB PurposeThis study aimed to investigate the role of salidroside (SAL) in the cellular communication between Muller cells and retinal ganglion cells in diabetic mice.MethodsThe diabetes mellitus (DM) animal models were established by the intraperitoneal injection of streptozotocin and treatment with SAL via gavage or by the injection of IL-22BP into the vitreous cavity. Immunohistochemistry was used to measure the expression of the glial fibrillary acidic protein in Muller cells. The expression of IL-22 and IL-22R alpha 1 in retinal tissues was assessed by immunofluorescence. Western blotting was used to measure the expression of inflammatory and apoptosis-related proteins. Hematoxylin-eosin staining, TUNEL staining, and flow cytometry were used to analyze the apoptosis of retinal ganglion cells. The effect of cellular interactions was explored by Transwell assays.ResultsWestern blotting showed that glial fibrillary acidic protein, IL-22 protein expression was significantly upregulated in the DM animal models compared with the control mice. Immunofluorescence showed that IL-22 was highly expressed in Muller cells and IL-22R alpha 1 was expressed in ganglion cells in the retina of DM mice. Hematoxylin-eosin and TUNEL staining results showed an increase in the number of ganglion cells apoptotic in DM. However, SAL reversed these phenomena. Meanwhile, after coculture with Muller cells, Western blotting suggested that ganglion cells secreted p-STAT3, and c-caspase3 protein expression was increased. More interestingly, the treatment of IL-22BP and SAL inhibited the expression of the p-STAT3 and c-caspase3 proteins. Flow cytometry indicates that compared with the control group, the apoptosis rate of ganglion cells was increased in the high glucose group, while the apoptosis rate of cells in the recombinant IL-22 protein group was significantly increased, while the SAL inhibited ganglion cells apoptosis.ConclusionSAL inhibits the apoptosis of retinal ganglion cells via the IL-22/STAT3 pathway in Muller cells.
C1 [Li, Jing; Liu, Wenqiang; Wang, Yufei; Liu, Anqi; Yu, Shengxue; Yu, Hongdan; Zuo, Zhongfu; Liu, Xuezheng] Jinzhou Med Univ, Liaoning Key Lab Diabetic Cognit & Percept Dysfunc, Jinzhou, Peoples R China.
   [Li, Jing] China Med Univ, Coll Basic Med Sci, Dept Anat, Shenyang, Peoples R China.
   [Liu, Wenqiang; Wang, Yufei; Liu, Anqi; Yu, Shengxue; Yu, Hongdan; Zuo, Zhongfu; Liu, Xuezheng] Jinzhou Med Univ, Dept Anat Histol & Embryol, Jinzhou, Peoples R China.
   [Zuo, Zhongfu] Guangxi Med Univ, Dept Anat Histol & Embryol, Postdoctoral Res Stn, Nanning, Peoples R China.
C3 Jinzhou Medical University; China Medical University; Jinzhou Medical
   University; Guangxi Medical University
RP Zuo, ZF; Liu, XZ (corresponding author), Jinzhou Med Univ, Liaoning Key Lab Diabetic Cognit & Percept Dysfunc, Jinzhou, Peoples R China.
EM zuozhongfu@jzmu.edu.cn; liuxuezheng@jzmu.edu.cn
RI /AAS-9154-2020
FU National Natural Science Foundation of China [81571383]; China
   Postdoctoral Science Foundation [2017M612870]
FX This study was supported by National Natural Science Foundation of China
   [No. 81571383] and China Postdoctoral Science Foundation [No.
   2017M612870].
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NR 50
TC 5
Z9 8
U1 0
U2 12
PU TAYLOR & FRANCIS INC
PI PHILADELPHIA
PA 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA
SN 0271-3683
EI 1460-2202
J9 CURR EYE RES
JI Curr. Eye Res.
PD AUG 3
PY 2023
VL 48
IS 8
BP 758
EP 769
DI 10.1080/02713683.2023.2204208
EA JUN 2023
PG 12
WC Ophthalmology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Ophthalmology
GA M5DM3
UT WOS:001002503900001
PM 37287123
DA 2026-05-27
ER

PT J
AU Zhang, TT
   Liao, XY
   Ren, J
   Chen, C
   Wan, YY
   Wang, F
   Chen, ZL
AF Zhang, Ting-Ting
   Liao, Xiao-Yan
   Ren, Jing
   Chen, Chen
   Wan, Yu-Ying
   Wang, Fang
   Chen, Zi-Lin
TI Construction of ERGO film modified electrode and its combination with
   HPLC in determination of five active components in Osmanthus
   fragrans fruits
SO CHINESE JOURNAL OF ANALYTICAL CHEMISTRY
LA Chinese
DT Article
DE Electrochemicallyreducedgrapheneoxide; Voltammetricbehaviours;
   Osmanthusfragransfruits; Phenylethanoidglycosides;
   Highperformanceliquidchromatography
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; ELECTROCHEMICAL DETECTION; RAT
   STRIATUM; NANOCOMPOSITE; BIOSENSOR; GLYCOSIDES; STRATEGY; ADENINE;
   VITRO; ACID
AB Neonuezhenide, nuezhenide, acteoside, isoacteoside and salidroside are common phenylethanoid glycosides in Osmanthus fragrans ( O. fragrans) fruits and have various physiological and pharmacological activities. The elec-trochemical determination of the five components in O. fragrans fruits was researched at electrochemically re-duced graphene oxide film modified glassy carbon electrode (ERGO/GCE). ERGO film was prepared by one-step deposition and showed a honeycombed network structure and provided good conductivity, controllability and stability. Compared with bare GCE or chemically reduced graphene oxide film modified electrode (RGO/GCE), the voltammetric behaviours of all five active components were improved at ERGO/GCE in terms of peak current and potential due to excellent electrical properties of ERGO. The numbers of protons and electrons transferred in electrochemical redox reaction were calculated and the possible electrode processes of five components have been estimated herein. The number of electrons involved was equal to that of protons transferred in the electrode processes for each compound and it was 2 for neonuezhenide, 1 for nuezhenide, 4 for acteoside, 4 for isoacteoside, and 1 for salidroside, respectively. Finally, a simple electrochemical method was developed for determination of the five components. This method has wide linear range with low detection limit of 3 ??M for neonuezhenide, 6 ??M for nuezhenide, 4 ??M for acteoside, 3 ??M for isoacteoside, and 3 ??M for salidroside, respectively. Moreover, this method could be coupled with high performance liquid chromatography (HPLC) and applied to determina-tion of the five active components in extractive from O. fragrans fruits. Compared with high performance liquid chromatography-mass spectrometry (HPLC-MS), this method would be competitive and alternative for the anal-ysis of active components in real samples.
C1 [Wang, Fang; Chen, Zi-Lin] Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Peoples R China.
   Wuhan Univ, Sch Pharmaceut Sci, Wuhan 430071, Peoples R China.
C3 Wuhan University
RP Wang, F; Chen, ZL (corresponding author), Hubei Prov Engn & Technol Res Ctr Fluorinated Pha, Minist Educ, Key Lab Combinatorial Biosynth & Drug Discovery, Wuhan 430071, Peoples R China.
EM fwang@whu.edu.cn; chenzl@whu.edu.cn
RI ; zhang, ting/HRC-8865-2023
OI , fang/0000-0003-3717-3936; 
FU National Natural Science Foundation of China [21778041]
FX This work was supported by the National Natural Science Foundation of
   China (Grant Nos. 21778041).
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NR 45
TC 0
Z9 0
U1 0
U2 15
PU SCIENCE PRESS
PI BEIJING
PA 16 DONGHUANGCHENGGEN NORTH ST, Building 5, Room 411, BEIJING, 100009,
   PEOPLES R CHINA
SN 0253-3820
EI 1872-2040
J9 CHINESE J ANAL CHEM
JI Chin. J. Anal. Chem.
PD JUL
PY 2022
VL 50
IS 7
DI 10.1016/j.cjac.2022.100109
EA MAY 2022
PG 8
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 2W7HE
UT WOS:000824690600001
DA 2026-05-27
ER

PT J
AU Zhang, N
   Guo, SN
   Du, LQ
   Ren, XY
AF Zhang, Nuo
   Guo, Shuo-Nan
   Du, Liang-Qi
   Ren, Xiao-Yu
TI Crystal structure of (2S,3S,4S,5S,
   Z)-2,3,5,6-tetrakis(benzyloxy)-4-hydroxyhexanal oxime,
   C34H37NO6
SO ZEITSCHRIFT FUR KRISTALLOGRAPHIE-NEW CRYSTAL STRUCTURES
LA English
DT Article
DE 2254652
ID SALIDROSIDE
AB C34H37NO6, triclinic, P (1) over bar (no. 2), a = 6.398(6) angstrom, b = 10.779(10) angstrom, c = 12.030(11) angstrom, alpha = 71.103(10)degrees, beta = 89.519(11)degrees, gamma = 74.154(11)degrees, V = 752.2(12) angstrom(3), Z = 1, R-gt(F) = 0.0599, wR(ref)(F-2) = 0.1614, T = 296 K.
C1 [Zhang, Nuo; Guo, Shuo-Nan; Du, Liang-Qi; Ren, Xiao-Yu] North China Univ Sci & Technol, Coll Pharm, Caofeidian Dist 063210, Tangshan, Peoples R China.
C3 North China University of Science & Technology
RP Zhang, N (corresponding author), North China Univ Sci & Technol, Coll Pharm, Caofeidian Dist 063210, Tangshan, Peoples R China.
EM ZN0731999@163.com
RI guo, shuo/MVW-8784-2025; Zhang, Nuodi/LSK-7365-2024
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NR 9
TC 0
Z9 0
U1 0
U2 2
PU WALTER DE GRUYTER GMBH
PI BERLIN
PA GENTHINER STRASSE 13, D-10785 BERLIN, GERMANY
SN 1433-7266
EI 2197-4578
J9 Z KRIST-NEW CRYST ST
JI Z. Krist.-New Cryst. Struct.
PD DEC 15
PY 2023
VL 238
IS 6
BP 1035
EP 1037
DI 10.1515/ncrs-2023-0174
EA SEP 2023
PG 3
WC Crystallography
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Crystallography
GA X7UQ3
UT WOS:001068033500001
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Boudermine, S
   Malafronte, N
   Mencherini, T
   Esposito, T
   Aquino, RP
   Beghidja, N
   Benayache, S
   D'Ambola, M
   Vassallo, A
AF Boudermine, Sihem
   Malafronte, Nicola
   Mencherini, Teresa
   Esposito, Tiziana
   Aquino, Rita Patrizia
   Beghidja, Noureddine
   Benayache, Samir
   D'Ambola, Massimiliano
   Vassallo, Antonio
TI Phenolic Compounds from Limonium pruinosum
SO NATURAL PRODUCT COMMUNICATIONS
LA English
DT Article
DE Limonium pruinosum; Plumbaginaceae; Phenolic compounds; NMR
ID FLAVONOL GLYCOSIDES; ANTIOXIDANT; SAPONINS; LEAVES
AB A new phenolic compound, 6'-O-sulfonyl-salidroside (1), together with fifteen known compounds, were isolated from the all parts of Limonium pruinosum. Their structures were elucidated by 1D and 2D NMR experiments including 1D TOCSY, DQF-COSY, HSQC and HMBC spectroscopy, as well as ESIMS analysis. The antioxidant activity of the extracts and all isolated compounds was evaluated by DPPH test.
C1 [Boudermine, Sihem; Beghidja, Noureddine; Benayache, Samir] Univ Constantine 1, Dept Chem, Res Unit, Constantine, Algeria.
   [Boudermine, Sihem; Malafronte, Nicola; Mencherini, Teresa; Esposito, Tiziana; Aquino, Rita Patrizia] Univ Salerno, Dipartimento Farm, I-84084 Fisciano, SA, Italy.
   [D'Ambola, Massimiliano] Univ Naples Federico II, Dipartimento Med Vet & Prod Anim, I-80137 Naples, Italy.
   [Vassallo, Antonio] Univ Basilicata, Dipartimento Sci, I-83100 Potenza, Italy.
C3 Universite Constantine; University of Salerno; University of Naples
   Federico II; University of Basilicata
RP Vassallo, A (corresponding author), Univ Basilicata, Dipartimento Sci, Viale Ateneo Lucano 10, I-83100 Potenza, Italy.
EM antonio.vassallo@unibas.it
RI ; Benayache, Samir/AAA-6130-2022; ESPOSITO, TIZIANA/ACP-4888-2022;
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OI D'Ambola, Massimiliano/0000-0001-8415-5672; Benayache,
   Samir/0000-0003-2298-2466; ESPOSITO, TIZIANA/0000-0002-0330-8292;
   Mencherini, Teresa/0000-0001-8207-0085; Boudermine,
   Sihem/0009-0006-0008-2108; aquino, rita patrizia/0000-0002-9754-4244;
   Vassallo, Antonio/0000-0001-7937-3309
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NR 15
TC 15
Z9 15
U1 1
U2 11
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 1934-578X
EI 1555-9475
J9 NAT PROD COMMUN
JI Nat. Prod. Commun.
PD FEB
PY 2015
VL 10
IS 2
BP 319
EP 321
PG 3
WC Chemistry, Medicinal; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Food Science & Technology
GA CB7MR
UT WOS:000349812000028
PM 25920273
DA 2026-05-27
ER

PT J
AU Jiang, B
   Cui, YY
   Ma, XX
   Zhang, YM
   Feng, X
   Yang, T
   Feng, LF
   Guo, WJ
   Li, YY
   Wang, T
   Guo, H
   Li, HN
   Duan, Y
   Su, HX
AF Jiang, Bing
   Cui, Yangyang
   Ma, Xinxin
   Zhang, Yanmei
   Feng, Xin
   Yang, Tao
   Feng, Longfei
   Guo, Wenjing
   Li, Yangyang
   Wang, Tao
   Guo, Huan
   Li, Haining
   Duan, Ying
   Su, Haixiang
TI Crosstalk between autophagy inhibitor and salidroside-induced apoptosis:
   A novel strategy for autophagy-based treatment of hepatocellular cancer
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Salidroside; Liver cancer; Autophagy; Mitochondrial apoptosis;
   Crosstalk; PI3K/Akt/mTOR
ID NETWORK PHARMACOLOGY; BREAST-CANCER; P62/SQSTM1; INTERPLAY; CELLS
AB Autophagy regulates many cell function related to cancer, including cell proliferation, invasion and apoptosis. Therefore, we investigated the potential value of crosstalk between autophagy and apoptosis. The present study demonstrated that seven autophagy related genes were screened from the biological network of salidroside (Sal) acting on liver cancer. The GO analysis showed that these genes were mainly involved in apoptosis and autophagy. The KEGG analysis showed that these genes regulated the process of liver cancer through Th17 cell differentiation, PI3K-Akt signaling pathway and other pathways. Moreover, seven genes were positively correlated with tumor purity, number of B cells, number of CD4(+) T cells, number of CD8(+) T cells, number of macrophages, number of dendritic cells and number of neutrophils. The overall survival time of liver cancer patients in the high expression group of BIRC5, HSP90AB1 and MTOR was lower than that in the low expression group (P < 0.05), while the overall survival time of the liver cancer patients in the high expression group of DLC1 and FOXO1 was higher than that in the low expression group (P < 0.05). In the pan-cancer analysis, we also found that BIRC5, HSP90AB1, MTOR, and ITGA6 were highly expressed in various cancers, while DLC1, FOXO1, and FOS were low expressed in various cancers. In the molecule docking analysis, we found that FOS, HSP90AB1, and MTOR had the best binding ability. Notably, in the vitro validation experiments, Sal was confirmed to induce autophagy and apoptosis, inhibite invasion and metastasis of liver cancer cells through the PI3K/Akt/mTOR signaling pathway. Meanwhile, inhibition of autophagy by chloroquine diphosphate (CQ) promoted Sal-induced mitochondrial apoptosis via corresponding cell and animal experiments. We speculated that Sal-induced autophagy might be a protective mechanism, inhibition of autophagy could further promote the progression of liver cancer. It may provide important insight into the molecular mechanism of crosstalk between autophagy and apoptosis, and provide a new theoretical basis of Sal combined with autophagy inhibitors as a adjuvant chemotherapeutic strategy for human liver cancer.
C1 [Jiang, Bing; Cui, Yangyang; Guo, Huan; Su, Haixiang] Gansu Univ Tradit Chinese Med, Dept Integrated Chinese & Western Med, Lanzhou 730000, Gansu, Peoples R China.
   [Ma, Xinxin; Zhang, Yanmei; Feng, Xin; Yang, Tao; Feng, Longfei; Guo, Wenjing; Li, Yangyang] Gansu Univ Tradit Chinese Med, Dept Basic Med, Lanzhou 730000, Gansu, Peoples R China.
   [Wang, Tao; Guo, Huan; Li, Haining; Su, Haixiang] Gansu Prov Canc Hosp, Gansu Prov Acad Inst Med Res, Translat Med Res Ctr, Lanzhou 730050, Gansu, Peoples R China.
   [Duan, Ying] Gansu Prov Canc Hosp, Dept Ultrasound, Lanzhou 730050, Gansu, Peoples R China.
   [Su, Haixiang] Gansu Prov Canc Hosp, Gansu Prov Acad Inst Med Res, Translat Med Res Ctr, 2 Xiaoxihu East St, Lanzhou 730050, Gansu, Peoples R China.
C3 Gansu University of Chinese Medicine; Gansu University of Chinese
   Medicine; Gansu Provincial Cancer Hospital (Gansu Provincial Academic
   Institute for Medical Research); Gansu Provincial Cancer Hospital (Gansu
   Provincial Academic Institute for Medical Research); Gansu Provincial
   Cancer Hospital (Gansu Provincial Academic Institute for Medical
   Research)
RP Su, HX (corresponding author), Gansu Prov Canc Hosp, Gansu Prov Acad Inst Med Res, Translat Med Res Ctr, 2 Xiaoxihu East St, Lanzhou 730050, Gansu, Peoples R China.
EM SHXsuhaixiang54120@163.com
RI SU, HAIXIANG/B-7347-2018; cui, yangyang/HZH-4860-2023; Feng,
   Xin/AAY-4922-2021
OI Wang, Tao/0009-0005-8146-2382
FU Key Talent Project of Gansu Province [2021RCXM057]; Longyuan Youth
   Innovation and Entrepreneurship Talent Project in Gansu Province
   [2022LQGR76]; Program of Technology Plan in Gansu Province [18JR2FA010];
   Research Project of Traditional Chinese Medicine in Gansu Province
   [GZKP-2021-21]; Lanzhou Science and Technology Plan Project [2021-1-90];
   Gansu Provincial Department of Education: "Double First-Class" Key
   Scientific Research Project [GSSYLXM-08]
FX This work was supported by the Key Talent Project of Gansu Province
   (Grant No. 2021RCXM057) , the Longyuan Youth Innovation and
   Entrepreneurship Talent Project in Gansu Province (Grant No. 2022LQGR76)
   , the Program of Technology Plan in Gansu Province (Grant No.
   18JR2FA010) , the Research Project of Traditional Chinese Medicine in
   Gansu Province (Grant No. GZKP-2021-21) , the Lanzhou Science and
   Technology Plan Project (Grant No. 2021-1-90) and the Gansu Provincial
   Department of Education: "Double First-Class" Key Scientific Research
   Project (Grant No. GSSYLXM-08,-09) .
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NR 50
TC 15
Z9 18
U1 3
U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD NOV
PY 2023
VL 124
AR 111040
DI 10.1016/j.intimp.2023.111040
EA OCT 2023
PN B
PG 18
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA Y0DQ6
UT WOS:001102065700001
PM 37839277
OA hybrid
DA 2026-05-27
ER

PT J
AU Li, MY
   Wang, S
   Fu, CM
   Chen, HY
   Su, YX
   Wu, P
   Yan, XH
   Gao, JJ
AF Li, Minyan
   Wang, Sha
   Fu, Chunmei
   Chen, Hongyu
   Su, Yuxia
   Wu, Peng
   Yan, Xinhao
   Gao, Juanjuan
TI Neuroprotective effects of salidroside against 6-OHDA-induced oxidative
   stress in PC12 cells
SO NEW JOURNAL OF CHEMISTRY
LA English
DT Article
AB Parkinson's disease (PD) is the second-most common neurodegenerative disease, and the development and progression of PD is characterized by oxidative stress (OS). This study determined the neuroprotective effects of salidroside (Sal). We report that Sal with scavenging ROS capabilities could regulate oxidative stress for the prevention of pathologic & alpha;-synuclein (& alpha;-syn) transmission in 6-hydroxydopamine (6-OHDA)-induced neurotoxicity in PC12 cells. Sal exhibits effective free radical quenching ability and safe use in biological systems. The protective effects of Sal against 6-OHDA-induced neurotoxicity in PC12 cells were investigated using the DPPH method for free radical scavenging, CCK8 for cell viability, DCFH-DA for ROS levels, immunohistochemical staining for & alpha;-syn, and western blot for SOD, CAT, and GPX4 protein detection. The results obtained through our studies showed that 6-OHDA-induced neurotoxicity significantly decreased cell viability, antioxidant enzyme (SOD, CAT, and GPX4) expression, increased ROS levels, and & alpha;-syn accumulation, while on Sal (50 mg mL(-1)) pretreatment obviously regulated the cellular redox balance and decreased & alpha;-syn accumulation. With further study, these findings may provide new insight into the protective mechanisms against neurodegenerative diseases and synucleinopathies.
C1 [Li, Minyan; Wang, Sha; Fu, Chunmei; Chen, Hongyu; Wu, Peng; Yan, Xinhao] Hanzhong Vocat & Tech Coll, Hanzhong Key Lab Clin Mol Biol, Hanzhong 723002, Peoples R China.
   [Gao, Juanjuan] Hanzhong Peoples Hosp, Dept Neurol, Hanzhong 723000, Peoples R China.
   [Su, Yuxia] Hanzhong Peoples Hosp, Dept Pharm, Hanzhong 723000, Peoples R China.
RP Wu, P; Yan, XH (corresponding author), Hanzhong Vocat & Tech Coll, Hanzhong Key Lab Clin Mol Biol, Hanzhong 723002, Peoples R China.; Gao, JJ (corresponding author), Hanzhong Peoples Hosp, Dept Neurol, Hanzhong 723000, Peoples R China.
EM gaojuanjuan1984@163.com
RI Wu, Peng/PNI-9720-2026
FU Shaanxi Province High-level Talent Introduction Program; Youth
   Innovation Team of Education Department of Shaanxi Provincial Government
   [22JP004]
FX This work was funded by the Shaanxi Province High-level Talent
   Introduction Program, the Youth Innovation Team of Education Department
   of Shaanxi Provincial Government (No. 22JP004). The authors are grateful
   to Mrs Jie Yang and Prof. Huanping An for providing the PC12 cells and
   w1118 flies used in this study.
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NR 32
TC 3
Z9 3
U1 1
U2 13
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 1144-0546
EI 1369-9261
J9 NEW J CHEM
JI New J. Chem.
PD JUL 24
PY 2023
VL 47
IS 29
BP 14039
EP 14045
DI 10.1039/d3nj01746j
EA JUN 2023
PG 7
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA M4SQ4
UT WOS:001022279900001
DA 2026-05-27
ER

PT J
AU Wang, XB
   Zhang, YT
   Hou, Y
   Jiang, H
   Kuang, TT
   Li, R
   Meng, XL
AF Wang, Xiaobo
   Zhang, Yating
   Hou, Ya
   Jiang, Hong
   Kuang, Tingting
   Li, Rui
   Meng, Xianli
TI Mechanistic Insights into Salidroside's Mitochondrial Protection via
   AMPK/Sirt1/HIF-1α Pathway in Hypoxic HT22 Cells
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
DE ruilee@cdutcm.edu.cn; xlm999@cdutcm.edu.cn
ID BRAIN
AB Salidroside (Sal), an active ingredient of Rhodiola crenulata (Hook. f. et Thoms.) H. Ohba has been found to exert mitochondrial protective effects by improving metabolism and enhancing the energy supply of brain cells under hypoxic conditions. However, its mechanism of action has not been fully clarified. In the present study, high-performance liquid chromatography was first employed to analyze the effects of Sal on nucleotide (ATP, ADP, and AMP) levels. The cellular thermal shift assay (CETSA), a widely used molecular interaction method for validating and quantifying drug target engagement in cells and tissues across different species, was then chosen to confirm the affinity of Sal for AMPK/Sirt1/HIF-1 alpha pathway-related proteins. The results revealed that Sal increased ATP and ADP levels in hypoxic HT22 cells while reducing AMP levels. Moreover, Sal exhibited stable binding to AMPK alpha, p-AMPK alpha, Sirt1, and HIF-1 alpha proteins. In conclusion, Sal may exert mitochondrial protective effects by modulating the AMPK/Sirt1/HIF-1 alpha pathway to regulate nucleotide content. This study provides a methodological reference for nucleotide content analysis in cell samples and contributes to the identification and discovery of targets for compounds derived from traditional Chinese medicine.
C1 [Wang, Xiaobo; Zhang, Yating; Hou, Ya; Jiang, Hong; Kuang, Tingting; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Sch Pharm, Sch Modern Chinese Med Ind, Chengdu, Peoples R China.
   [Wang, Xiaobo; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Acad Interdiscipline, Chengdu, Peoples R China.
   [Wang, Xiaobo; Li, Rui; Meng, Xianli] Tradit Chinese Med Hosp Meishan, Res Serv Off, Meishan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Wang, XB; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, Sch Modern Chinese Med Ind, Chengdu, Peoples R China.; Wang, XB; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Acad Interdiscipline, Chengdu, Peoples R China.; Wang, XB; Li, R; Meng, XL (corresponding author), Tradit Chinese Med Hosp Meishan, Res Serv Off, Meishan, Peoples R China.
EM Vitadrwang@cdutcm.edu.cn; ruilee@cdutcm.edu.cn; xlm999@cdutcm.edu.cn
FU National Natural Science Foundation of China [82274207, 82474185];
   Science & Technology Department of Sichuan Province [2024NSFSC1845];
   Science Foundation for Youths of Science & Technology Department of
   Sichuan Province [2023NSFSC1776]; Key Research and Development Program
   of Ningxia [2023BEG02012]; Youth Talent Support Project of the China
   Association of Chinese Medicine [2024-QNRC2-B07]; Xinglin Scholar
   Research Promotion Project of Chengdu University of TCM [XKTD2022013,
   QJJJ2024027]
FX This work was supported by the National Natural Science Foundation of
   China (82274207 and 82474185) , the Science & Technology Department of
   Sichuan Province (2024NSFSC1845) , the Science Foundation for Youths of
   Science & Technology Department of Sichuan Province (2023NSFSC1776) ,
   the Key Research and Development Program of Ningxia (2023BEG02012) ,
   Youth Talent Support Project of the China Association of Chinese
   Medicine for 2024-2026 (2024-QNRC2-B07) and the Xinglin Scholar Research
   Promotion Project of Chengdu University of TCM (XKTD2022013 and
   QJJJ2024027) .
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NR 35
TC 10
Z9 10
U1 14
U2 18
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD APR
PY 2025
IS 218
AR e66923
DI 10.3791/66923
PG 12
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 2FN2E
UT WOS:001481432800004
PM 40354296
DA 2026-05-27
ER

PT J
AU Li, YM
   Wu, J
   Shi, RX
   Li, N
   Xu, ZC
   Sun, M
AF Li, Yongmei
   Wu, Jue
   Shi, Ruixiu
   Li, Na
   Xu, Zhice
   Sun, Miao
TI Antioxidative Effects of Rhodiola Genus: Phytochemistry and
   Pharmacological Mechanisms against the Diseases
SO CURRENT TOPICS IN MEDICINAL CHEMISTRY
LA English
DT Review
DE Rhodiola; traditional medicines; reactive oxygen species; superoxide
   dismutase; disease; epigenetics
ID CHINESE NATURAL MEDICINES; ROSEA L. EXTRACT; NF-KAPPA-B; OXIDATIVE
   STRESS; SALIDROSIDE PROTECTS; DIABETIC-RETINOPATHY; BIOACTIVE
   CONSTITUENTS; MONOTERPENE GLYCOSIDES; ELECTROSPRAY-IONIZATION;
   CHEMICAL-COMPOSITION
AB Rhodiola as one of traditional medicines has been used for clinical treatments due to its strong antioxidant properties. Phytochemical analysis revealed the presence of flavonoids, phenyl-propanoids, phenylethanol/benzyl alcohol derivatives, cyanogenic glycosides and terpenoids. The bioactive compounds had been demonstrated to be effective at scavenging reactive oxygen species (ROS). The structures contain phenolic hydroxyl groups and unsaturated bonds. This article reviews antioxidant capacities of the extracts and bioactive components derived from Rhodiola plants. As the major pharmacological ingredient, salidroside is rigorously investigated and used in scientific researches and clinical practices. Accumulated evidences indicated that extracts of Rhodiola plants or salidro side could be able to reverse DNA damage and alter expression of cytokines and antioxidative enzymes induced by ROS. The underlying mechanisms for the antioxidative effects of the herb have been investigated in the last two decades. We summarize the possible effects and acting pathways for the herb involved in several chronic diseases in cardiovascular, respiratory, and nervous systems, as well as potential epigenetic influences. The information generated from experimental and clinical studies offered valuable insights for further investigations of medical potentials of Rhodiola plants.
C1 [Li, Yongmei; Wu, Jue; Shi, Ruixiu; Li, Na; Xu, Zhice; Sun, Miao] Soochow Univ, Inst Fetol, Hosp 1, Suzhou 215006, Peoples R China.
   [Li, Yongmei] Municipal Hosp, Dept Obstet & Gynecol, Suzhou, Peoples R China.
C3 Soochow University - China
RP Sun, M (corresponding author), Soochow Univ, Inst Fetol, Hosp 1, Suzhou 215006, Peoples R China.
EM miaosunsuda@163.com
RI miao, sun/E-2834-2018; Li, Na/GQO-9936-2022
FU China Grant [2013BA104B05]; NSFC [81320108006]
FX Supported by China Grant 2013BA104B05, NSFC Grants 81320108006.
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NR 167
TC 26
Z9 33
U1 3
U2 68
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1568-0266
EI 1873-4294
J9 CURR TOP MED CHEM
JI Curr. Top. Med. Chem.
PY 2017
VL 17
IS 15
BP 1692
EP 1708
DI 10.2174/1568026617666161116141334
PG 17
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ET7UP
UT WOS:000400504800003
PM 27848900
DA 2026-05-27
ER

PT J
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   Jang, S
   Kim, J
   Ali, Z
   Khan, IA
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AF Lee, Yeonju
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TI Anti-Inflammatory and Neuroprotective Effects of Constituents Isolated
   from Rhodiola rosea
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID PITUITARY-ADRENAL AXIS; NITRIC-OXIDE; BRAIN-DAMAGE; DOUBLE-BLIND;
   CELL-DEATH; STRESS; ACTIVATION; EXTRACT; SHR-5; RAT
AB To determine the biological activity of Rhodiola rosea, the protein expression of iNOS and proinflammatory cytokines was measured after the activation of murine microglial BV2 cells by LPS under the exposure of constituents of Rhodiola rosea: crude extract, rosin, rosarin, and salidroside (each 1-50 mu g/mL). The LPS-induced expression of iNOS and cytokines in BV2 cells was suppressed by the constituents of Rhodiola rosea in a concentration-dependent manner. Also the expression of the proinflammatory factors iNOS, IL-1 beta, and TNF-alpha in the kidney and prefrontal cortex of brain in mice was suppressed by the oral administration of Rhodiola rosea crude extract (500 mg/kg). To determine the neuroprotective effect of constituents of Rhodiola rosea, neuronal cells were activated by L-glutamate, and neurotoxicity was analyzed. The L-glutamate-induced neurotoxicity was suppressed by the treatment with rosin but not by rosarin. The level of phosphorylated MAPK, pJNK, and pp38 was increased by L-glutamate treatment but decreased by the treatment with rosin and salidroside. These results indicate that Rhodiola rosea may have therapeutic potential for the treatment of inflammation and neurodegenerative disease.
C1 [Lee, Yeonju; Jung, Jae-Chul; Jang, Soyong; Kim, Jieun; Oh, Seikwan] Ewha Womans Univ, Sch Med, Dept Neurosci, Seoul 158710, South Korea.
   [Lee, Yeonju; Jung, Jae-Chul; Jang, Soyong; Kim, Jieun; Oh, Seikwan] Ewha Womans Univ, Sch Med, Tissue Injury Def Res Ctr, Seoul 158710, South Korea.
   [Ali, Zulfiqar; Khan, Ikhlas A.] Univ Mississippi, Thad Cochran Res Ctr, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA.
C3 Ewha Womans University; Ewha Womans University; University of
   Mississippi
RP Oh, S (corresponding author), Ewha Womans Univ, Sch Med, Dept Neurosci, Seoul 158710, South Korea.
EM skoh@ewha.ac.kr
RI Khan, Ikhlas/AAA-1490-2020
FU Korea Research Foundation Grant (MRC) [2010-0029355]; Korean Government
   (MEST)
FX This work was supported by the Korea Research Foundation Grant (MRC,
   2010-0029355) funded by the Korean Government (MEST).
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NR 48
TC 53
Z9 69
U1 1
U2 26
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2013
VL 2013
AR 514049
DI 10.1155/2013/514049
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 132VX
UT WOS:000318097900001
PM 23690847
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhao, XL
   Zhang, KY
   Lei, XJ
   Yang, F
   Li, HJ
   Li, Y
   Xu, C
   Liu, SJ
   Li, ZX
   Shi, SJ
   Gan, K
   Niu, ZP
   Zhang, JL
   Zhang, JY
   Wen, WH
   Zhang, R
   Wang, AH
   Han, DH
   Qin, WJ
AF Zhao, Xiaolong
   Zhang, Keying
   Lei, Xiaoju
   Yang, Fa
   Li, Hongji
   Li, Yu
   Xu, Chao
   Liu, Shaojie
   Li, Zhengxuan
   Shi, Shengjia
   Gan, Kai
   Niu, Zhiping
   Zhang, Jingliang
   Zhang, Jiayu
   Wen, Weihong
   Zhang, Rui
   Wang, Anhui
   Han, Donghui
   Qin, Weijun
TI Salidroside mitigates Oligoasthenospermia by attenuating ferroptosis via
   NF-κB pathway inhibition
SO PHYTOMEDICINE
LA English
DT Article
DE Oligoasthenospermia; Salidroside; Ferroptosis; NF-kappa B pathway; Lipid
   peroxidation; GPX4
ID OXIDATIVE STRESS; CELL-DEATH; SPERMATOZOA; IMPROVES; RATS
AB Background: : Oligoasthenospermia (OAS) leads to male infertility, significantly impacting patients and their families. Previous studies have identified various mechanisms involved in OAS, including oxidative stress, apoptosis, and autophagy. Ferroptosis, a novel cell death form, is also linked to male infertility. Despite advancements, the involvement of ferroptosis in spermatogenesis and its potential role in causing OAS, as well as the identification of safe and effective natural drugs targeting this mechanism, remain unclear. Purpose: : This study aimed to investigate the potential role of ferroptosis in OAS and explore safe and effective inhibitors for treatment. Study design and methods: : Semen samples were collected from patients with OAS. Mouse models of OAS were induced using cyclophosphamide (CP) in vivo, and GC-2 cells were treated in vitro. The effects of salidroside (Sal) on mice and GC-2 cells were evaluated using various methods, including ATP, malondialdehyde, and glutathione peroxidase activity assays; transmission electron microscopy; immunohistochemistry; flow cytometry; lipid peroxidation (LPO) analysis; mitochondrial membrane potential (MMP) assessment; enzyme-linked immunosorbent assays; qRT-PCR; western blotting; RNA sequencing; and immunofluorescence. Results: : Human OAS sperm exhibits biochemical and morphological hallmarks of ferroptosis. Ferroptosis is crucial in CP-induced OAS in mice in vivo, and its inhibition can effectively improve OAS. Further search for safe and stable natural compounds found Sal improved the sperm quality by attenuating ferroptosis-mediated LPO in germ cells through increased GPX4 expression, thereby ameliorating OAS in vivo. Immunohistochemistry revealed that Sal increases GPX4 expression starting from primary spermatocytes, highlighting its action stage during spermatogenesis. In vitro, these results were verified using a mouse spermatocyte cell line, GC-2 cells. Mechanistically, RNA-Seq and bioinformatic analysis suggest that Sal likely promotes GPX4 expression by inhibiting the NF-kappa B pathway, thereby reducing ferroptosis. Conclusion: : Ferroptosis plays an important role in OAS, and Sal could ameliorate OAS by attenuating ferroptosis via NF-kappa B pathway inhibition.
C1 [Zhao, Xiaolong; Zhang, Keying; Yang, Fa; Li, Hongji; Xu, Chao; Liu, Shaojie; Li, Zhengxuan; Gan, Kai; Zhang, Jingliang; Han, Donghui; Qin, Weijun] Air Force Med Univ, Xijing Hosp, Dept Urol, 127 West Changle Rd, Xian 710032, Peoples R China.
   [Lei, Xiaoju] Sunresin New Mat Co Ltd, Dept Life Sci, 135 Jinye Rd, Xian 710076, Peoples R China.
   [Li, Yu] Army Med Univ, Daping Hosp, Dept Urol, 10 Changjiang Branch Rd, Chongqing 400042, Peoples R China.
   [Shi, Shengjia] Northwest Womens & Childrens Hosp, Reprod Ctr, 73 Houzai Gate, Xian 710004, Peoples R China.
   [Niu, Zhiping] Fudan Univ, Sch Publ Hlth, Dept Environm Hlth, 130 Dongan Rd, Shanghai 200032, Peoples R China.
   [Zhang, Jiayu] Air Force Hosp Southern Theater Command, Dept Urol, Guangzhou 510062, Guangdong, Peoples R China.
   [Wen, Weihong] Northwestern Polytech Univ, Inst Med Res, 127 Youyi Rd, Xian 710072, Peoples R China.
   [Zhang, Rui] Air Force Med Univ, Dept Immunol, 169 West Changle Rd, Xian 710032, Peoples R China.
   [Wang, Anhui] Air Force Med Univ, Sch Prevent Med, Dept Epidemiol, 169 West Changle Rd, Xian 710032, Peoples R China.
C3 Air Force Medical University; Army Medical University; Fudan University;
   Northwestern Polytechnical University; Air Force Medical University; Air
   Force Medical University
RP Han, DH; Qin, WJ (corresponding author), Air Force Med Univ, Xijing Hosp, Dept Urol, 127 West Changle Rd, Xian 710032, Peoples R China.; Wang, AH (corresponding author), Air Force Med Univ, Sch Prevent Med, Dept Epidemiol, 169 West Changle Rd, Xian 710032, Peoples R China.
EM wangah@fmmu.edu.cn; handonghui@fmmu.edu.cn; qinwj@fmmu.edu.cn
RI ; Niu, Zhiping/AAK-2847-2021
OI Qin, Weijun/0000-0002-7509-7164; 
FU National Natural Science Foundation of China [82,202,933, 82,201,774,
   82,503,946]; Key Research and Development Projects of Shaanxi Province
   [2025SF-YBXM-370]; Shaanxi Province Health Research Capacity Enhancement
   Program Key Research and Development Project [2025YF-27]; Key Project of
   the Incubation Fund of Northwest Women and Children's Hospital
   [2024FH02]
FX This study was funded by the National Natural Science Foundation of
   China (No. 82,202,933, No. 82,201,774, and No. 82,503,946) , Key
   Research and Development Projects of Shaanxi Province (No.
   2025SF-YBXM-370) , Shaanxi Province Health Research Capacity Enhancement
   Program Key Research and Development Project (2025YF-27) , and Key
   Project of the Incubation Fund of Northwest Women and Children's
   Hospital (2024FH02) .
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NR 48
TC 2
Z9 2
U1 5
U2 5
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JAN
PY 2026
VL 150
AR 157633
DI 10.1016/j.phymed.2025.157633
EA DEC 2025
PG 14
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA T1593
UT WOS:001637315900001
PM 41351983
OA hybrid
DA 2026-05-27
ER

PT J
AU Xu, ZM
   Liu, S
   Lai, HN
   You, LJ
   Zhao, ZA
AF Xu, Zhengming
   Liu, Shuang
   Lai, Huining
   You, Lijun
   Zhao, Zhengang
TI Green-Efficient Enzymatic Synthesis and Characterization of Liposoluble
   6′/6"-O-Lauryl Phenolic Glycosides with Enhanced Intestinal
   Permeability
SO JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
LA English
DT Article
DE phenolic glycoside esters; lipase; catalysis; lipophilicity;
   carboxylesterase; transport
ID LIPASE-CATALYZED SYNTHESIS; ANTIOXIDANT PROPERTIES; DRUG PERMEABILITY;
   HIGHLY EFFICIENT; CACO-2 CELLS; ABSORPTION; DERIVATIVES; TRANSPORT;
   ESTERS; COEFFICIENTS
AB Arbutin, salidroside, polydatin, and phlorizin are typicallynaturalbioactive phenolic glycosides. To improve the liposolubility and bioavailability,highly liposoluble derivatives including 6 '-O-lauryl arbutin, 6 '-O-lauryl salidroside,6 ''-O-lauryl polydatin, and 6 ''-O-lauryl phlorizin were efficiently synthesized by enzymaticacylation in a green solvent 2-MeTHF. Their reaction conversions reached84.4, 99.5, 99.8, and 89.1%, respectively, when catalyzed by Lipozyme435 at 20 mg/mL at 50 degrees C. As expected, the derivatives had highlog P (1.66-2.37) and retained goodantioxidant activity, making them potential alternatives to butylatedhydroxytoluene (BHT) and tert-butyl-hydroquinone(TBHQ) in lipid systems. Then, the intestinal permeability characteristicsand metabolism of phenolic glycosides and their derivatives were investigatedbased on Caco-2 monolayers. The permeability of polydatin and phlorizinwas mainly through active transport, but that of arbutin and salidrosideinvolved both passive diffusion and active uptake. The acylated derivativessuffered from severe CES-mediated hydrolysis but exhibited a largertransported amount than phenolic glycosides.
C1 [Xu, Zhengming; Liu, Shuang; Lai, Huining; You, Lijun; Zhao, Zhengang] South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China.
   [Zhao, Zhengang] South China Univ Technol, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Guangzhou 510640, Peoples R China.
C3 South China University of Technology; South China University of
   Technology
RP Zhao, ZA (corresponding author), South China Univ Technol, Sch Food Sci & Engn, Guangzhou 510640, Peoples R China.; Zhao, ZA (corresponding author), South China Univ Technol, Guangdong Prov Key Lab Green Proc Nat Prod & Prod, Guangzhou 510640, Peoples R China.
EM fezzg@scut.edu.cn
RI Zhao, Zhengang/B-2701-2018; YOU, LIJUN/AAD-7043-2019; Xu,
   Zhengming/LMP-5902-2024
OI Zhao, Zhengang/0000-0003-0539-2544; YOU, LIJUN/0000-0001-7873-3894; 
FU National Natural Science Foundation of China [22078112]; Science and
   Technology Planning Project of Xinjiang Production and Construction
   Corps [2021BC006]
FX This study was supported by the National Natural Science Foundation of
   China (22078112) and the Science and Technology Planning Project of
   Xinjiang Production and Construction Corps (2021BC006).
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NR 36
TC 10
Z9 10
U1 8
U2 50
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0021-8561
EI 1520-5118
J9 J AGR FOOD CHEM
JI J. Agric. Food Chem.
PD MAY 11
PY 2023
VL 71
IS 20
BP 7689
EP 7702
DI 10.1021/acs.jafc.3c00527
PG 14
WC Agriculture, Multidisciplinary; Chemistry, Applied; Food Science &
   Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Chemistry; Food Science & Technology
GA J4LK2
UT WOS:001009342200001
PM 37167604
DA 2026-05-27
ER

PT J
AU Huang, J
   Zhao, DD
   Cui, CJ
   Hao, JX
   Zhang, ZT
   Guo, LM
AF Huang, Jin
   Zhao, Dandan
   Cui, Chaojing
   Hao, Jianxiong
   Zhang, Zhentao
   Guo, Limin
TI Research Progress and Trends of Phenylethanoid Glycoside Delivery
   Systems
SO FOODS
LA English
DT Article
DE drug delivery; phenylethanoid glycoside; bioavailability; biological
   activity; nanoemulsion; liposome; nanoparticle
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; IN-VITRO; ECHINACOSIDE; SALIDROSIDE;
   PHARMACOKINETICS; ACTEOSIDE; BIOAVAILABILITY; ABSORPTION; STABILITY;
   VERBASCOSIDE
AB Background: Phenylethanoid glycosides (PhGs) are obtained from a wide range of sources and show strong biological and pharmacological activities, such as antioxidant, antibacterial and neuroprotective effects. However, intestinal malabsorption and the low bioavailability of PhGs seriously affect their application. Delivery systems are an effective method to improve the bioavailability of active substances. Scope and approach: In this article, the biological activities of and delivery systems for PhGs are introduced. The application statuses of delivery systems for echinacoside, acteoside and salidroside are reviewed. Finally, the problems of the lack of uniform standards for delivery systems and the poor targeted delivery accuracy of PhGs in the current research are proposed and suggestions for future research are put forward based on those problems. Key findings and conclusions: Although there are still some problems in the delivery system of phenylethanoside, such as inconsistent standards and inaccurate delivery, phenylethanoside itself has been proven to have a variety of physiological activities. Therefore, the action mechanism and application of phenylethanoside and its delivery system should be studied further.
C1 [Huang, Jin; Zhao, Dandan; Cui, Chaojing; Hao, Jianxiong] Hebei Univ Sci & Technol, Coll Food Sci & Biol, Shijiazhuang 051432, Hebei, Peoples R China.
   [Zhang, Zhentao] Tech Inst Phys & Chem CAS, Beijing 100190, Peoples R China.
   [Guo, Limin] Xinjiang Acad Agr Sci, Inst Agroprod Storage & Proc, Urumqi 830091, Peoples R China.
C3 Hebei University of Science & Technology; Chinese Academy of Sciences;
   Technical Institute of Physics & Chemistry, CAS; Xinjiang Academy of
   Agricultural Sciences
RP Zhao, DD (corresponding author), Hebei Univ Sci & Technol, Coll Food Sci & Biol, Shijiazhuang 051432, Hebei, Peoples R China.; Guo, LM (corresponding author), Xinjiang Acad Agr Sci, Inst Agroprod Storage & Proc, Urumqi 830091, Peoples R China.
EM huangjin202110@163.com; zdd2016@hebust.edu.cn; ccjhhxx2021@163.com;
   cauhjx@163.com; zzth1@163.com; 201431190023@mail.bnu.edu.cn
RI ; Zhao, Dandan/HHN-7387-2022; Zhang, Zhentao/JQV-7389-2023; Hao,
   Jianxiong/HSG-5813-2023
OI 张, 振涛/0000-0002-3621-329X; Zhao, Dandan/0000-0003-2315-6190; 
FU regional collaborative innovation project of The Autonomous Region
   [2020E01048]; Shijiazhuang Science and Technology Research and
   Development Program [211170272A, 211170322A]
FX FundingThis research was funded by [the regional collaborative
   innovation project of The Autonomous Region (Project 2020E01048) and the
   Shijiazhuang Science and Technology Research and Development Program
   (211170272A and 211170322A)].
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NR 84
TC 27
Z9 29
U1 2
U2 82
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2304-8158
J9 FOODS
JI Foods
PD MAR
PY 2022
VL 11
IS 5
AR 769
DI 10.3390/foods11050769
PG 16
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA ZS9KU
UT WOS:000768777700001
PM 35267401
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Rong, X
   Lu, PP
   Li, Y
   Wang, HX
   Yue, YJ
   Wang, HM
   Ji, Z
   Jiang, L
AF Rong, Xing
   Lu, Peipei
   Li, Yu
   Wang, Hongxiang
   Yue, Yuanjia
   Wang, Huimin
   Ji, Zhao
   Jiang, Lin
TI Salidroside Attenuates Cerebral Ischemia-Reperfusion Injury via
   ERβ/BNIP3-Mediated Mitochondrial Autophagy Activation in a Rat Model
SO NEUROCHEMICAL RESEARCH
LA English
DT Article
DE BNIP3; Cerebral ischemia; ER beta; Mitochondrial autophagy; Salidroside
ID ESTROGEN; HYPOXIA
AB This study aimed to assess the neuroprotective effects of salidroside (SAL) on cerebral ischemia-reperfusion injury (CIRI) in a rat model and to elucidate the underlying mechanisms, with a focus on the role of estrogen receptor beta (ER beta) and BCL2 interacting protein 3 (BNIP3)-mediated mitochondrial autophagy as potential therapeutic targets in ischemic stroke. A total of 165 female Sprague-Dawley rats were randomly assigned into 11 groups (n = 15 per group). One group served as the control. The remaining animals underwent bilateral ovariectomy and were subsequently allocated into the following groups: ovariectomy-only, middle cerebral artery occlusion/reperfusion (MCAO/R), estradiol control, ER beta inhibitor, two inhibitor arms (inhibitor-only and inhibitor-plus-SAL), three SAL treatment groups (low, mediummitochondrial division, high dose), and a positive control (edaravone). All groups, except the control and ovariectomy-only groups, were subjected to MCAO for one hour followed by 24 h of reperfusion. Neurological function, cerebral infarct volume, blood-brain barrier (BBB) permeability, and brain water content were evaluated. Histopathological alterations were assessed, and transmission electron microscopy was employed to detect autophagosomes. Western blot analysis was performed to quantify protein expression levels of ER beta, BNIP3, NIP3-like protein X, and microtubule-associated protein 1 A/1B-light chain 3. Administration of SAL and edaravone significantly reduced neurological impairment, infarct volume, BBB disruption, and cerebral edema in the MCAO/R model. SAL treatment upregulated ER beta and BNIP3 expression and enhanced mitochondrial autophagy-associated protein levels. These effects were attenuated by the use of ER beta and mitochondrial division inhibitors, indicating a mechanistic link between SAL-mediated neuroprotection and activation of the ER beta/BNIP3 signaling axis. SAL exerts a neuroprotective effect against CIRI in rats, primarily through activation of ER beta and enhancement of BNIP3-mediated mitochondrial autophagy. These findings suggest that modulation of the ER beta/BNIP3 pathway may represent a promising therapeutic approach for ischemic stroke.
C1 [Rong, Xing; Wang, Huimin; Jiang, Lin] Xinjiang Autonomous Reg Hosp Tradit Chinese Med, Dept Pharm, Urumqi 830000, Xinjiang Uygur, Peoples R China.
   [Lu, Peipei; Wang, Hongxiang] Xinjiang Med Univ, Clin Med Coll 4, Urumqi 830000, Xinjiang Uygur, Peoples R China.
   [Li, Yu; Ji, Zhao] Xinjiang Uygur Autonomous Reg Peoples Hosp, Surg Intens Care Unit, Urumqi 830000, Xinjiang Uygur, Peoples R China.
   [Yue, Yuanjia] Shihezi Municipal Peoples Hosp, Dept Pharm, Urumqi 832061, Xinjiang Uygur, Peoples R China.
C3 Xinjiang Medical University
RP Jiang, L (corresponding author), Xinjiang Autonomous Reg Hosp Tradit Chinese Med, Dept Pharm, Urumqi 830000, Xinjiang Uygur, Peoples R China.
EM JLin@xjmu.edu.cn
RI lu, peipei/GQQ-4262-2022; Yue, Yuan-Jia/HGD-4787-2022
FU Natural Science Foundation of Xinjiang Uygur Autonomous Region
FX We would like to acknowledge the hard and dedicated work of all the
   staff that implemented the intervention and evaluation components of the
   study.
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NR 42
TC 2
Z9 2
U1 3
U2 4
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0364-3190
EI 1573-6903
J9 NEUROCHEM RES
JI Neurochem. Res.
PD SEP 11
PY 2025
VL 50
IS 5
AR 297
DI 10.1007/s11064-025-04535-3
PG 12
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA 7EU3O
UT WOS:001569314300002
PM 40932658
DA 2026-05-27
ER

PT J
AU Lei, W
   Chen, MH
   Huang, ZF
   Chen, XY
   Wang, JX
   Zheng, J
   Zhu, YZ
   Lan, XZ
   He, Y
AF Lei, Wei
   Chen, Mei-hong
   Huang, Zu-feng
   Chen, Xiao-ying
   Wang, Jin-xia
   Zheng, Jing
   Zhu, Yi-zhun
   Lan, Xiao-zhong
   He, Yuan
TI Salidroside protects pulmonary artery endothelial cells against
   hypoxia-induced apoptosis via the AhR/NF-KB and Nrf2/HO-1 pathways
SO PHYTOMEDICINE
LA English
DT Article
DE Pulmonary hypertension; Salidroside; Apoptosis; Aryl hydrocarbon
   receptor; Nuclear factor erythroid 2-related factor 2
ID ARYL-HYDROCARBON RECEPTOR; OXIDATIVE STRESS; HYPERTENSION; INJURY
AB Background: The apoptosis of pulmonary artery endothelial cells (PAECs) is an important factor contributing to the development of pulmonary hypertension (PH), a serious cardio-pulmonary vascular disorder. Salidroside (SAL) is a bioactive compound derived from an herb Rhodiola , but the potential protective effects of SAL on PAECs and the underlying mechanisms remain elusive. Purpose: The objective of this study was to determine the role of SAL in the hypoxia-induced apoptosis of PAECs and to dissect the underlying mechanisms. Study design: Male Sprague-Dawley (SD) rats were subjected to hypoxia (10% O 2 ) for 4 weeks to establish a model of PH. Rats were intraperitoneally injected daily with SAL (2, 8, and 32 mg/kg/d) or vehicle. To define the molecular mechanisms of SAL in PAECs, an in vitro model of hypoxic cell injury was also generated by exposed PAECs to 1% O 2 for 48 h. Methods: Various techniques including hematoxylin and eosin (HE) staining, immunofluorescence, flow cytometry, CCK-8, Western blot, qPCR, molecular docking, and surface plasmon resonance (SPR) were used to determine the role of SAL in rats and in PAECs in vitro. Results: Hypoxia stimulation increases AhR nuclear translocation and activates the NF- K B signaling pathway, as evidenced by upregulated expression of CYP1A1, CYP1B1, IL-1 (i , and IL-6, resulting in oxidative stress and inflammatory response and ultimately apoptosis of PAECs. SAL inhibited the activation of AhR and NF- K B, while promoted the nuclear translocation of Nrf2 and increased the expression of its downstream antioxidant proteins HO -1 and NQO1 in PAECs, ameliorating the hypoxia-induced oxidative stress in PAECs. Furthermore, SAL lowered right ventricular systolic pressure, and decreased pulmonary vascular remodeling and right ventricular hypertrophy in hypoxia-exposed rats. Conclusions: SAL may attenuate the apoptosis of PAECs by suppressing NF- K B and activating Nrf2/HO-1 pathways, thereby delaying the progressive pathology of PH.
C1 [Lei, Wei; Wang, Jin-xia; Lan, Xiao-zhong; He, Yuan] Tibet Agr & Anim Husb Univ, Ctr Xizang Chinese Tibetan Med Resource, Joint Lab Tibetan Mat Med Resources Sci Protect &, Tibetan Med Res Ctr Tibet,TAAHC GDMU Biomed & Hlt, Nyingchi 860000, Tibet, Peoples R China.
   [Lei, Wei; Chen, Mei-hong; He, Yuan] Guangdong Med Univ, Affiliated Hosp, GDMU TAAHC Biomed & Hlth Joint R&D Ctr, Dept Precis Lab,Guangdong Prov Engn Technol Res C, Zhanjiang, Guangdong, Peoples R China.
   [Chen, Mei-hong; Huang, Zu-feng; Chen, Xiao-ying; Wang, Jin-xia; He, Yuan] Guangdong Med Univ, Lab Cardiovasc Dis, Affiliated Hosp, Zhanjiang, Guangdong, Peoples R China.
   [Zheng, Jing] Univ Wisconsin, Dept Obstet & Gynecol, Madison, WI USA.
   [Zhu, Yi-zhun] Macau Univ Sci & Technol, Fac Chinese Med, State Key Lab Qual Res Chinese Med, Macau, Peoples R China.
   [He, Yuan] Guangdong Med Univ, Affiliated Hosp, Dept Precis Lab, 57 Renmin Southern Rd, Zhanjiang 524001, Guangdong, Peoples R China.
   [Lan, Xiao-zhong] Tibet Agr & Anim Husb Univ, Nyingchi 860000, Tibet, Peoples R China.
C3 Xizang Agricultural & Animal Husbandry University; Guangdong Medical
   University; Guangdong Medical University; University of Wisconsin
   System; University of Wisconsin Madison; Macau University of Science &
   Technology; Guangdong Medical University; Xizang Agricultural & Animal
   Husbandry University
RP He, Y (corresponding author), Guangdong Med Univ, Affiliated Hosp, Dept Precis Lab, 57 Renmin Southern Rd, Zhanjiang 524001, Guangdong, Peoples R China.; Lan, XZ (corresponding author), Tibet Agr & Anim Husb Univ, Nyingchi 860000, Tibet, Peoples R China.
EM lanxiaozhong@xza.edu.cn; heyuan@gdmu.edu.cn
RI ; Zheng, Jing/AGB-4759-2022
OI Lei, Wei/0000-0002-4033-4799; 
FU National Natural Science Foundation of China [81970056]; Discipline
   Construction Project of Guangdong Medical University [4SG21233G]; Key
   platform of Department of Education of Guangdong Province [2021LSYS007];
   Zhanjiang Science and Technology Development Special Funding Competitive
   Allocation Project [2022E05011, 2022A01196, 2021A05158, 2021A05058,
   2021A05056, 2020A01020, 2020A06004]
FX The present study was supported by the National Natural Science
   Foundation of China (81970056) , Discipline Construction Project of
   Guangdong Medical University (4SG21233G) , Key platform of Department of
   Education of Guangdong Province (2021LSYS007) , and Zhanjiang Science
   and Technology Development Special Funding Competitive Allocation
   Project (2022E05011, 2022A01196, 2021A05158, 2021A05058, 2021A05056,
   2020A01020, 2020A06004) .
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NR 50
TC 39
Z9 46
U1 8
U2 58
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUN
PY 2024
VL 128
AR 155376
DI 10.1016/j.phymed.2024.155376
EA MAR 2024
PG 13
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA PW7K2
UT WOS:001217182200001
PM 38503152
OA hybrid
DA 2026-05-27
ER

PT J
AU Ma, XB
   Li, SY
   Qiu, JJ
   Liu, ZJ
   Liu, SY
   Huang, ZF
   Yong, YH
   Li, YQ
   Yu, ZC
   Liu, XX
   Lin, HL
   Ju, XH
   Abd El-Aty, AM
AF Ma, Xingbin
   Li, Shuyu
   Qiu, Jiajie
   Liu, Zijie
   Liu, Siyu
   Huang, Zhifeng
   Yong, Yanhong
   Li, Youquan
   Yu, Zhichao
   Liu, Xiaoxi
   Lin, Hongling
   Ju, Xianghong
   Abd El-Aty, A. M.
TI Development of an Fe3O4 Surface-Grafted
   Carboxymethyl Chitosan Molecularly Imprinted Polymer for Specific
   Recognition and Sustained Release of Salidroside
SO POLYMERS
LA English
DT Article
DE drug delivery systems; salidroside; molecularly imprinted polymer;
   chitosan embedding Fe3O4 microspheres; drug release kinetics
ID DRUG-DELIVERY; HYDROGELS; AGENT
AB The choice of carrier material is critical in the study of natural drug release preparations and glycosylated magnetic molecularly imprinted materials. The stiffness and softness of the carrier material affect the efficiency of drug release and the specificity of recognition. The dual adjustable aperture-ligand in molecularly imprinted polymers (MIPs) provides the possibility of individualized design for sustained release studies. In this study, a combination of paramagnetic Fe3O4 and carboxymethyl chitosan (CC) was used to enhance the imprinting effect and improve drug delivery. A combination of tetrahydrofuran and ethylene glycol was used as a binary porogen to prepare MIP-doped Fe3O4-grafted CC (SMCMIP). Salidroside serves as the template, methacrylic acid acts as the functional monomer, and ethylene glycol dimethacrylate (EGDMA) serves as the crosslinker. Scanning and transmission electron microscopy were used to observe the micromorphology of the microspheres. The structural and morphological parameters of the SMCMIP composites were measured, including the surface area and pore diameter distribution. In an in vitro study, we found that the SMCMIP composite had a sustained release property of 50% after 6 h of release time in comparison to the control SMCNIP. The total amounts of SMCMIP released at 25 degrees C and 37 degrees C were 77% and 86%, respectively. In vitro results showed that the release of SMCMIP followed Fickian kinetics, meaning that the rate of release is dependent on the concentration gradient, with diffusion coefficients ranging from 3.07 x 10(-2) cm(2)/s to 5.66 x 10(-3) cm(2)/s. The results of cytotoxicity experiments showed that the SMCMIP composite did not have any harmful effects on cell growth. The survival rates of intestinal epithelial cells (IPEC-J2) were found to be above 98%. By using the SMCMIP composite, drugs may be delivered in a sustained manner, potentially leading to improved therapeutic outcomes and reduced side effects.
C1 [Ma, Xingbin; Li, Shuyu; Qiu, Jiajie; Liu, Zijie; Liu, Siyu; Huang, Zhifeng; Yong, Yanhong; Li, Youquan; Yu, Zhichao; Liu, Xiaoxi; Ju, Xianghong] Guangdong Ocean Univ, Coll Coastal Agr Sci, Zhanjiang 524088, Peoples R China.
   [Lin, Hongling] Chinese Acad Trop Agr Sci, Southern Subtrop Crop Res Inst, Zhanjiang Expt Stn, Zhanjiang 524013, Peoples R China.
   [Abd El-Aty, A. M.] Cairo Univ, Fac Vet Med, Dept Pharmacol, Giza 12211, Egypt.
   [Abd El-Aty, A. M.] Ataturk Univ, Med Fac, Dept Med Pharmacol, TR-25240 Erzurum, Turkiye.
C3 Guangdong Ocean University; Chinese Academy of Tropical Agricultural
   Sciences; Egyptian Knowledge Bank (EKB); Cairo University; Ataturk
   University
RP Ma, XB (corresponding author), Guangdong Ocean Univ, Coll Coastal Agr Sci, Zhanjiang 524088, Peoples R China.; Lin, HL (corresponding author), Chinese Acad Trop Agr Sci, Southern Subtrop Crop Res Inst, Zhanjiang Expt Stn, Zhanjiang 524013, Peoples R China.
EM mxb1984612@126.com; lhl122446@126.com
RI Ju, Xianghong/PFI-9514-2025; 俞, 智超/HZK-4346-2023; Abd El-Aty, A.
   M/H-8216-2018
OI Ju, Xianghong/0000-0001-8822-484X; Xiaoxi, Liu/0000-0002-4533-5221; Abd
   El-Aty, A. M/0000-0001-6596-7907; Liu, Zijie/0000-0001-7310-2479
FU a project supported by the Natural Science Foundation of Guangdong
   Province, China [2022A1515010576] Funding Source: Medline; the Program
   for Scientific Research Start-Fund of Guangdong Ocean University
   [101402/R20063] Funding Source: Medline; Notice of Guangdong
   International and Hong Kong, Macao and Taiwan high-end Talents Exchange
   in 2021-2022 [300702/K21425] Funding Source: Medline
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NR 30
TC 9
Z9 9
U1 3
U2 36
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2073-4360
J9 POLYMERS-BASEL
JI Polymers
PD MAR
PY 2023
VL 15
IS 5
AR 1187
DI 10.3390/polym15051187
PG 14
WC Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Polymer Science
GA 9T5IT
UT WOS:000947060600001
PM 36904428
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Huang, YP
   Han, XD
   Tang, JY
   Long, X
   Wang, XY
AF Huang, Yongpan
   Han, Xiaodong
   Tang, Jiayu
   Long, Xian
   Wang, Xiaoye
TI Salidroside inhibits endothelial-mesenchymal transition via the
   KLF4/eNOS signaling pathway
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE salidroside; endothelial-mesenchymal transition; Kruppel-like factor 4;
   endothelial nitric oxide synthase
ID SMOOTH-MUSCLE-CELLS; CONTRIBUTES; EXPRESSION; PROTECTS
AB Homocysteine (Hcy) was discovered to be an independent risk factor for the development of atherosclerosis (AS). Moreover, endothelial-mesenchymal transition (EndMT) was found to be one of main mechanisms contributing to the pathogenesis of AS. Salidroside (SAL) has diverse pharmacological activities, including anti-inflammatory, anti-cancer, anti-oxidative and anti-fibrosis properties. However, whether SAL serves a beneficial role in Hcy-induced EndMT remains unknown. The present study aimed to investigate whether SAL exerted its effects on Hcy-induced EndMT via the Kruppel-like factor 4 (KLF4)/endothelial nitric oxide (NO) synthase (eNOS) signaling pathway. HUVECs were pretreated with high and low doses (10 or 50 mu mol/l) of SAL for 2 h, followed by 1 mmol/l Hcy for 48 h to induce EndMT. Western blotting was used to analyze the protein expression levels of the endothelial marker, VE-cadherin, the mesenchymal cell marker, alpha-smooth muscle actin (SMA), and the nuclear transcription factors, KLF4 and eNOS. Wound healing assays were used to determine the cell migratory ability, and the levels of NO in the cell culture supernatants were measured using a nitrate reductase assay. Cellular immunofluorescence was used to analyze the expression and localization of KLF4. Small interfering (si)RNA targeting KLF4 (siKLF4) was used to knock down KLF4 expression in HUVECs. The results of the present study revealed that treatment with SAL upregulated the expression levels of VE-cadherin, downregulated the expression levels of alpha-SMA, reduced cell migration and activated the eNOS/NO signaling axis, as well as downregulated KLF4 expression and translocation to the nucleus. Compared with the SAL + siKLF4 co-administration group, no significant differences were observed in the expression levels of the phenotypic markers in the SAL or siKLF4 groups. In conclusion, the findings of the present study revealed that SAL may inhibit Hcy-induced EndMT via regulation of the KLF4/eNOS signaling pathway.
C1 [Huang, Yongpan; Long, Xian] Changsha Social Work Coll, Sch Med, Dept Clin, Changsha 410004, Hunan, Peoples R China.
   [Han, Xiaodong] Yanan Univ, Dept Anesthesia, Coll Med, Yanan 716000, Shanxi, Peoples R China.
   [Han, Xiaodong] Xian Int Med Ctr Hosp, Dept Anesthesia, Xian 710100, Shanxi, Peoples R China.
   [Tang, Jiayu; Wang, Xiaoye] Brain Hosp Hunan Prov, Dept Neurol, 427 Furong Middle Rd, Changsha 410007, Hunan, Peoples R China.
C3 Changsha Social Work College; Yanan University
RP Wang, XY (corresponding author), Brain Hosp Hunan Prov, Dept Neurol, 427 Furong Middle Rd, Changsha 410007, Hunan, Peoples R China.
EM hnnkyy_xiaoyewang@163.com
FU Scientific Research Project of Hunan Provincial Department of Education
   [19B043]; Yan'an University Science Foundation Project [YDQ2020-06];
   Hunan Provincial Administration of Traditional Chinese Medicine Research
   Project Fund [202083]; Academy of Finland (AKA) [202083] Funding Source:
   Academy of Finland (AKA)
FX TThis work was funded by Scientific Research Project of Hunan Provincial
   Department of Education (grant no. 19B043), the Yan'an University
   Science Foundation Project (grant no. YDQ2020-06) and the Hunan
   Provincial Administration of Traditional Chinese Medicine Research
   Project Fund (grant no. 202083).
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NR 26
TC 18
Z9 20
U1 0
U2 15
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD OCT
PY 2021
VL 24
IS 4
AR 692
DI 10.3892/mmr.2021.12324
PG 7
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA UB2TI
UT WOS:000685703200001
PM 34368873
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Chen, X
   Deng, AQ
   Zhou, HZ
   Gu, JH
AF Chen, Xia
   Deng, Aiqing
   Zhou, Hongzhi
   Gu, Jinhua
TI Neuroprotective effect of
   2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxy-β-d-pyranoside against
   sodium nitroprusside-induced neurotoxicity in HT22 cells
SO MOLECULAR AND CELLULAR BIOCHEMISTRY
LA English
DT Article
DE 2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-beta-D-pyranoside; SNP;
   Apoptosis; HT22 cells
ID FOCAL CEREBRAL-ISCHEMIA; NITRIC-OXIDE; INDUCED APOPTOSIS; PC12 CELLS;
   BCL-2 FAMILY; DEATH; SALIDROSIDE; NITRATION; INJURY; BRAIN
AB 2-(4-Methoxyphenyl) ethyl-2-acetamido-2-deoxy-beta-d-pyranoside (GlcNAc-Sal), the salidroside analog was synthesized and shown to inhibit hypoglycemia and serum limitation induced apoptosis in PC12 cells. This study investigated the protective effects of GlcNAc-Sal on sodium nitroprusside (SNP)-induced cytotoxicity in HT22 cells. Cell viability tests and Hoechst 33342 staining comfirmed that GlcNAc-Sal pretreatment attenuated SNP-stimulated apoptotic cell death in HT22 cells in a concentration-dependent manner. The measurements of reactive oxygen species (ROS), nitric oxide (NO) production and apoptosis-related gene and protein expression suggest that the protection of GlcNAc-Sal, shown in this study, might be mediated by inhibiting intracellular ROS and NO production, and regulating apoptosis-related gene and protein expression during SNP stimulation. Perhaps, this study might contribute to the development of GlcNAc-Sal as an agent for preventing and/or treating a variety of NO-induced brain diseases.
C1 [Chen, Xia; Deng, Aiqing; Gu, Jinhua] Nantong Univ, Sch Med, Dept Pharmacol, Nantong 226001, Jiangsu, Peoples R China.
   [Zhou, Hongzhi] Nantong Univ, Affiliated Hosp 1, Dept Neurol, Nantong 226001, Jiangsu, Peoples R China.
C3 Nantong University; Nantong University
RP Chen, X (corresponding author), Nantong Univ, Sch Med, Dept Pharmacol, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China.
EM jsxiaohuang@163.com
FU Natural Science Foundation of the Jiangsu Higher Education Institutions
   of China [12KJD310002]; Science and Technology plan projects of Nantong
   Grant [BK2011042]
FX This Project was supported by the Natural Science Foundation of the
   Jiangsu Higher Education Institutions of China (Grant No. 12KJD310002)
   and the Science and Technology plan projects of Nantong Grant (No.
   BK2011042).
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NR 49
TC 5
Z9 7
U1 0
U2 12
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 0300-8177
J9 MOL CELL BIOCHEM
JI Mol. Cell. Biochem.
PD NOV
PY 2013
VL 383
IS 1-2
BP 149
EP 159
DI 10.1007/s11010-013-1763-y
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 227TC
UT WOS:000325136400016
PM 23873333
DA 2026-05-27
ER

PT J
AU Chaitanya, MVNL
   Patle, D
   Singh, SK
   Mazumder, A
   Sindhu, RK
   Dua, K
   Khurana, N
   Arora, P
AF Chaitanya, M. V. N. L.
   Patle, Deepshikha
   Singh, Sachin Kumar
   Mazumder, Avijit
   Sindhu, Rakesh Kumar
   Dua, Kamal
   Khurana, Navneet
   Arora, Prince
TI Salidroside and inflammation-linked disorders: integrative insights into
   the pharmacological effects and mechanistic targets
SO INFLAMMOPHARMACOLOGY
LA English
DT Review
DE Salidroside; Cellular inflammation; Antidiabetes; Rhodiola
   <italic>rosea</italic>; Mitochondrial activity; SH-SY5Y neuroblastoma
   cells
ID ISCHEMIA-REPERFUSION INJURY; RAT PLASMA; RHODIOLA-CRENULATA; P-TYROSOL;
   APOPTOSIS; NANOPARTICLES; INHIBITION; GLYCOSIDES; AUTOPHAGY; EXTRACT
AB Salidroside (SAL), a phenylpropanoid glycoside found in Rhodiola rosea L. roots, is one of the plant's most essential active components. Few studies have shown that it has many health advantages, particularly because it helps combat inflammation, prevent cell death, and protect cells from harm. Research indicated that SAL may protect cardiac myocytes from oxidative stress and enhance glucose uptake in skeletal muscle cells. It also significantly enhanced mitochondrial activity and prevented cell death in pheochromocytoma cells, SH-SY5Y neuroblastoma cells, and cardiomyocytes. Besides its advantages for cellular function, SAL is recognised for its protective effects on the heart and brain. Animal studies have shown efficacy in reducing lung damage induced by LPS and sepsis resulting from caecal ligation and puncture in murine models. SAL seems to enhance insulin resistance via activating a route that links mitochondria to AMPK, PI3K, Akt, and GSK-3 beta. Aqueous preparations of Rhodiola rosea have shown metabolic benefits by reducing blood glucose levels in streptozotocin-treated diabetic rats, an effect that is negated upon adrenal gland removal. The extensive array of pharmacological effects underscores the considerable therapeutic potential of SAL. Despite the well-documented advantages of SAL, research gaps persist regarding optimal dose, long-term safety, and comprehensive effectiveness comparisons in clinical environments. To assist researchers and clinicians in the biomedical sector in filling in the gaps in their knowledge and gaining a comprehensive picture of SAL's therapeutic applications and mechanisms, this review compiles the numerous results on these topics. It aims to simplify complicated material and highlight areas that need more investigation by integrating our present knowledge of SALs and their sources, biosynthesis, extraction, analysis, pharmacological effects, and molecular processes.Graphical abstractSAL's broad therapeutic spectrum and its key targets.
C1 [Chaitanya, M. V. N. L.; Patle, Deepshikha; Singh, Sachin Kumar; Khurana, Navneet] Lovely Profess Univ, Sch Pharmaceut Sci, Grand Trunk Rd, Phagwara 144411, Punjab, India.
   [Mazumder, Avijit] Noida Inst Engn & Technol, Pharm Inst, 19 Knowledge Pk 2, Greater Noida 201306, India.
   [Sindhu, Rakesh Kumar] Guru Jambheshwar Univ Sci & Technol, Dept Pharmaceut Sci, Hisar 125001, Haryana, India.
   [Dua, Kamal] Univ Technol Sydney, Grad Sch Hlth, Discipline Pharm, Ultimo, NSW 2007, Australia.
   [Arora, Prince] Lovely Profess Univ, Sch Comp Applicat, Grand Trunk Rd, Phagwara 144411, Punjab, India.
   [Dua, Kamal] Macquarie Univ, Woolcock Inst Med Res, Sydney, NSW, Australia.
   [Dua, Kamal] Uttaranchal Univ, Uttaranchal Inst Pharmaceut Sci, Dehra Dun, India.
C3 Lovely Professional University; Noida Institute of Engineering &
   Technology; Guru Jambheshwar University of Science & Technology;
   University of Technology Sydney; Lovely Professional University;
   Macquarie University; University of Sydney; Woolcock Institute of
   Medical Research; Uttaranchal University
RP Chaitanya, MVNL (corresponding author), Lovely Profess Univ, Sch Pharmaceut Sci, Grand Trunk Rd, Phagwara 144411, Punjab, India.
EM mvnlcdiamond@gmail.com
RI Chaitanya, MVNL/C-6497-2019; MAZUMDER, AVIJIT/I-6148-2016; Arora,
   Prince/HGV-2962-2022; SINGH, SACHIN/I-1948-2019; Patle,
   Dipesh/I-1448-2013; Sindhu, Rakesh K/HJA-9541-2022; Khurana,
   Navneet/AGJ-1666-2022
OI Chaitanya, MVNL/0000-0001-9432-2374; Dua, Kamal/0000-0002-7507-1159; 
FU School of Pharmaceutical Sciences, Lovely Professional University,
   Punjab, India
FX The authors gratefully acknowledge the support and encouragement
   provided by the School of Pharmaceutical Sciences, Lovely Professional
   University, Punjab, India. The institution's academic environment and
   research infrastructure have significantly contributed to the successful
   completion of this review work.
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NR 100
TC 3
Z9 3
U1 13
U2 17
PU SPRINGER BASEL AG
PI BASEL
PA PICASSOPLATZ 4, BASEL, 4052, SWITZERLAND
SN 0925-4692
EI 1568-5608
J9 INFLAMMOPHARMACOLOGY
JI Inflammopharmacology
PD OCT
PY 2025
VL 33
IS 10
BP 5861
EP 5887
DI 10.1007/s10787-025-01964-y
EA SEP 2025
PG 27
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA 8XK0F
UT WOS:001581657500001
PM 41003973
DA 2026-05-27
ER

PT J
AU Jiang, KL
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AF Jiang, Kanglun
   Wang, Tan
   Zhao, Zirui
   Zhou, Lei
   Jiang, Huaili
   Shen, Na
   Wu, Daquan
   Huang, Xinsheng
TI Salidroside Attenuates Cisplatin-Induced Ototoxicity: An Experimental
   Study In Vitro and In Vivo
SO JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
LA English
DT Article
DE Salidroside; Hearing Loss; Ototoxicity; Mitochondria; Cisplatin
ID RHODIOLA-ROSEA; MECHANISMS; PROTECTION; DISORDER; CHILDREN; PATHWAY;
   INJURY; DNA
AB Oxidative damage to hair cells is the major cause of ototoxicity induced by cisplatin (cis)-based chemotherapy. In this study, we aimed to assess how salidroside (SAL) protected cochlear explants (CEs) and HEI-OC1 cell lines against cis-induced ototoxicity and reduced relative hearing loss in mouse models. Furthermore, the protective mechanism of the Nrf2/ARE pathway was investigated. Cell Counting Kit-8 was used to measure the viability of HEI-OC1 cells. Flow cytometry and the TUNEL assay were used to evaluate cell apoptosis. Flow cytometry was used to measure intracellular reactive oxygen species (ROS). Immunofluorescence staining determined the changes in mitochondrial membrane potential (Altm). Western blot was used to measure the levels of caspase-3 and Nrf-2. An analysis of Nrf2 and target gene levels of expression was conducted using qRT-PCR. Hearing was monitored using auditory brainstem response audiometry. In cochlear explants, SAL inhibits cis-induced apoptosis of HEI-OC1 cells and decreased hair cell apoptosis. SAL inhibited cis-induced apoptosis by lowering intracellular ROS, preserving mitochondrial function, and reducing caspase-3 IP: 2038 10920 On: F i 07 Jul 2023 10:33:08 expression. Moreover, auditory cells were roteced from the toxic effets of ciby the Nrf2-ARE pathway after treatment Copyright: Amer can Scientific Publis hers with SAL.In vivo, SAL could protect against cis-inducedDeliverdhearingbyloss,ngentaand the use of the PLGA-poloxamer nanohydrogel as a carrier increased the protection efficiency of SAL. Through its ability to reduce oxidative stress, SAL could protect auditory cell lines from cis-induced apoptosis in vitro and attenuate cis-induced hearing loss in vivo. Nano-based drug delivery can improve the protection efficiency of SAL. Further research should be conducted on the antioxidant capacity of SAL and its use in ototoxicity.
C1 [Jiang, Kanglun; Wang, Tan; Zhou, Lei; Jiang, Huaili; Shen, Na; Wu, Daquan; Huang, Xinsheng] Fudan Univ, Zhongshan Hosp, Dept Otorhinolaryngol Head & Neck Surg, Shanghai 200032, Peoples R China.
   [Zhao, Zirui] Fudan Univ, Eye & ENT Hosp, ENT Inst, Shanghai 200031, Peoples R China.
   [Zhao, Zirui] Fudan Univ, Eye & ENT Hosp, Dept Otorhinolaryngol, Shanghai 200031, Peoples R China.
C3 Fudan University; Fudan University; Fudan University
RP Wu, DQ; Huang, XS (corresponding author), Fudan Univ, Zhongshan Hosp, Dept Otorhinolaryngol Head & Neck Surg, Shanghai 200032, Peoples R China.
EM wu.daquan@zs-hospital.sh.cn; huang.xinsheng@zs-hospital.sh.cn
RI Shen, Na/IUO-3617-2023; Zhou, Lei/S-3956-2017
FU Shanghai Science and Technology Committee Foundation; Key Project of
   National Natural Science Foundation of China [82000980]; National
   Natural Science Foundation;  [11932010];  [21Y31900500]
FX The work was supported by the Shanghai Science and Technology Committee
   Foundation under grant number 21Y31900500 National Natural Science
   Foundation under grant number 82000980, and the Key Project of National
   Natural Science Foundation of China under Grant Number 11932010.
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NR 45
TC 2
Z9 2
U1 0
U2 11
PU AMER SCIENTIFIC PUBLISHERS
PI VALENCIA
PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
SN 1550-7033
EI 1550-7041
J9 J BIOMED NANOTECHNOL
JI J. Biomed. Nanotechnol.
PD APR
PY 2023
VL 19
IS 4
BP 600
EP 612
DI 10.1166/jbn.2023.3559
PG 13
WC Nanoscience & Nanotechnology; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Materials Science
GA M0AD1
UT WOS:001026800200001
DA 2026-05-27
ER

PT J
AU Wang, YF
   Chang, YY
   Zhang, XM
   Gao, MT
   Zhang, QL
   Li, X
   Zhang, L
   Yao, WF
AF Wang, Yi-Fei
   Chang, Yue-yue
   Zhang, Xue-meng
   Gao, Meng-Ting
   Zhang, Qiu-lan
   Li, Xin
   Zhang, Li
   Yao, Wei-Feng
TI Salidroside protects against osteoporosis in ovariectomized rats by
   inhibiting oxidative stress and promoting osteogenesis via Nrf2
   activation
SO PHYTOMEDICINE
LA English
DT Article
DE Osteoporosis; Osteoblast; Salidroside; Oxidative stress; Ovariectomized
   rats; Nrf2
ID ESTROGEN REPLACEMENT THERAPY; LIGUSTRI-LUCIDI; ADIPOGENIC
   DIFFERENTIATION; PEROXIDATION; LIPOPROTEIN; EXPRESSION; PRODUCTS;
   NECROSIS; PATHWAY; FRUCTUS
AB Background: Osteoporosis (OP) is characterized as low bone mass, bone microarchitecture breakdown and bone fragility. The increase of oxidative stress could lead to breakdown in the balance of bone formation and resorption which gives rise to OP. Nrf2 is a transcription factor which takes part in oxidative stress and recently was reported that it can regulate the occurrence of OP. Salidroside (SAL) with the efficacies of anti-oxidation, anti-aging and bone-protection is one of the active ingredients in Ligustri Lucidi Fructus, a traditional Chinese medicinal herb. Nevertheless, few studies have explored the potential mechanism of SAL preventing OP development from the perspective of oxidative stress intervention. Purpose: This study aimed to investigate the pharmacological effect and molecular mechanisms of SAL on OP. Study designs and methods: A tert-butyl hydroperoxide (t-BHP)-induced oxidative stress model was applied for investigating the effects of SAL in vitro, and an ovariectomized (OVX) model was used for in vivo study on the effect of SAL for OP. Related pharmacodynamic actions and molecular mechanisms of SAL were explored in both rat osteoblasts (ROBs) and OVX rats. Network biology and cell metabolomics were performed for further investigating the correlation and association among potential biomarkers, targets and pathways. Results: SAL reduced levels of ROS and lipid peroxidation (LPO), increased activities of antioxidant enzymes like GPx and SOD, and enhanced osteogenic differentiation in t-BHP-induced ROBs and OVX rats. Mechanistic studies showed SAL prevented OP development and reduced oxidative damage in ROBs and OVX rats through up regulating Nrf2 expression and facilitating its nuclear translocation. The joint analysis of network biology and cell metabolomics revealed that galactose metabolism and fatty acid metabolism could be the major influenced pathways following treatment with SAL. Conclusion: SAL could protect against OP by inhibiting oxidative stress, promoting osteogenesis through the up -regulation of Nrf2 and intervening galactose metabolism and fatty acid metabolism. Our study implied that SAL may be a potential drug to treat OP.
C1 [Wang, Yi-Fei; Chang, Yue-yue; Zhang, Xue-meng; Gao, Meng-Ting; Zhang, Qiu-lan; Li, Xin; Zhang, Li; Yao, Wei-Feng] Nanjing Univ Chinese Med, Sch Pharm, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China.
   [Zhang, Li; Yao, Wei-Feng] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resour, Natl & Local Collaborat Engn Ctr Chinese Med Reso, Nanjing 210023, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing University of Chinese
   Medicine
RP Yao, WF (corresponding author), Nanjing Univ Chinese Med, Sch Pharm, 138 Xianlin Rd, Nanjing 210023, Jiangsu, Peoples R China.
EM yaowf@njucm.edu.cn
RI Yao, Weifeng/I-7394-2013
FU National Natural Science Foundation of China [81973445, 81573554];
   Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD) [2016-YY-026]; Qing Lan Project of Jiangsu Province
   [KYCX21_1806]; Six Talent Peaks Project in Jiangsu Province;
   Postgraduate Research and Practice Innovation Program of Jiangsu
   Province
FX Funding This work was financially supported by National Natural Science
   Foundation of China (Grant No. 81973445 and 81573554) , and A Project
   Funded by the Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD) . This research was also supported by A
   Project Funded by the Qing Lan Project of Jiangsu Province and Six
   Talent Peaks Project in Jiangsu Province (2016-YY-026) , Postgraduate
   Research and Practice Innovation Program of Jiangsu Province (No.
   KYCX21_1806) .
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NR 61
TC 60
Z9 77
U1 5
U2 54
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD MAY
PY 2022
VL 99
AR 154020
DI 10.1016/j.phymed.2022.154020
EA MAR 2022
PG 18
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 1B2CL
UT WOS:000792248700004
PM 35278902
DA 2026-05-27
ER

PT J
AU Fan, FF
   Yang, L
   Li, R
   Zou, XM
   Li, N
   Meng, XL
   Zhang, Y
   Wang, XB
AF Fan, Fangfang
   Yang, Lu
   Li, Rui
   Zou, Xuemei
   Li, Ning
   Meng, Xianli
   Zhang, Yi
   Wang, Xiaobo
TI Salidroside as a potential neuroprotective agent for ischemic stroke: a
   review of sources, pharmacokinetics, mechanism and safety
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Salidroside; Sources; Pharmacokinetics; Blood brain barrier; Ischemic
   stroke; Mechanism; Safety
ID BRAIN-BARRIER PERMEABILITY; HYDRO-ALCOHOLIC EXTRACTS; FOCAL
   CEREBRAL-ISCHEMIA; MESENCHYMAL STEM-CELLS; METABOLITE P-TYROSOL;
   RHODIOLA-ROSEA-L.; RAT PLASMA; CHEMICAL-CONSTITUENTS; GENE-EXPRESSION;
   IN-VITRO
AB Salidroside (Sal) is a bioactive extract principally from traditional herbal medicine such as Rhodiola rosea L., which has been commonly used for hundreds of years in Asia countries. The excellent neuroprotective capacity of Sal has been illuminated in recent studies. This work focused on the source, pharmacokinetics, safety and anti-ischemic stroke (IS) effect of Sal, especially emphasizing its mechanism of action and BBB permeability. Extensive databases, including Pubmed, Web of science (WOS), Google Scholar and China National Knowledge Infrastructure (CNKI), were applied to obtain relevant online literatures. Sal exerts powerful therapeutic effects on IS in experimental models either in vitro or in vivo due to its neuroprotection, with significantly diminishing infarct size, preventing cerebral edema and improving neurological function. Also, the findings suggest the underlying mechanisms involve anti-oxidation, anti-inflammation and anti-apoptosis by regulating multiple signaling pathways and key molecules, such as NF-kappa B, TNF-alpha and PI3K/Akt pathway. In pharmacokinetics, although showing a rapid absorption and elimination, bioavailability of Sal is elevated under some non-physiological conditions. The component and its metabolite (tyrosol) are capable of distributing to brain tissue and the later keeps a higher level of concentration. Moreover, Sal scarcely has obvious toxicity or side effects in a variety of animal experiments and clinical trials, but combination of drugs and perinatal use of medicine should be taken more attentions. Finally, as an active ingredient, not only is Sal isolated from diverse plants with limited yield, but also large batches of the products can be harvested by biological and chemical synthesis. With higher efficacy and better safety profiles, Sal could sever as a promising neuroprotectant for preventing and treating IS. Nevertheless, further investigations are still required to explore the pharmacodynamic and pharmacokinetic properties of Sal in the treatment of IS.
C1 [Fan, Fangfang; Zou, Xuemei; Li, Ning; Zhang, Yi] Chengdu Univ Tradit Chinese Med, Ethn Med Acad Heritage Innovat Res Ctr, Chengdu 611137, Peoples R China.
   [Yang, Lu; Li, Rui; Meng, Xianli; Wang, Xiaobo] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Zhang, Y (corresponding author), Chengdu Univ Tradit Chinese Med, Ethn Med Acad Heritage Innovat Res Ctr, Chengdu 611137, Peoples R China.; Meng, XL; Wang, XB (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu 611137, Peoples R China.
EM xlm999@cdutcm.edu.cn; zhangyi@cdutcm.edu.cn; 1461875871@qq.com
FU National Key RAMP;D Program of China [2017YFC1703904]; National Natural
   Science Foundation of China [81973569]; Major Science and Technology
   Project of Sichuan Science and Technology Department [19SYXHZ0095];
   Xinglin Scholar Research Premotion Project of Chengdu University of TCM
   [CXTD2018015, CXTD2018020]; Project First-Class Disciplines Development
   Of Chengdu University of TCM [CZYJC1903]; State Administration of
   Traditional Chinese Medicine of the People's Republic of China
   [201507002]
FX This work was supported by the National Key R&D Program of China
   (2017YFC1703904), the National Natural Science Foundation of China
   (81973569), the Major Science and Technology Project of Sichuan Science
   and Technology Department(19SYXHZ0095), Xinglin Scholar Research
   Premotion Project of Chengdu University of TCM (CXTD2018015 and
   CXTD2018020), Project First-Class Disciplines Development Of Chengdu
   University of TCM (CZYJC1903) and State Administration of Traditional
   Chinese Medicine of the People's Republic of China (201507002).
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NR 311
TC 103
Z9 120
U1 4
U2 70
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD SEP
PY 2020
VL 129
AR 110458
DI 10.1016/j.biopha.2020.110458
PG 19
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA NJ9OT
UT WOS:000566373800001
PM 32603893
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xing, SS
   Yang, XY
   Zheng, T
   Li, WJ
   Wu, D
   Chi, JY
   Bian, F
   Bai, XL
   Wu, GJ
   Zhang, YZ
   Zhang, CT
   Zhang, YH
   Li, YS
   Jin, S
AF Xing, Sha-Sha
   Yang, Xiao-Yan
   Zheng, Tao
   Li, Wen Jing
   Wu, Dan
   Chi, Jiang-Yang
   Bian, Fang
   Bai, Xiang-Li
   Wu, Guang-Jie
   Zhang, You-Zhi
   Zhang, Cun-Tai
   Zhang, Yong-Hui
   Li, Yong-Sheng
   Jin, Si
TI Salidroside improves endothelial function and alleviates atherosclerosis
   by activating a mitochondria-related AMPK/PI3K/Akt/eNOS pathway
SO VASCULAR PHARMACOLOGY
LA English
DT Article
DE Atherosclerosis; Endothelial dysfunction; Salidroside; Mitochondria
ID NITRIC-OXIDE SYNTHASE; PROTEIN-KINASE AMPK; ENOS PHOSPHORYLATION; AKT
   ACTIVITY; OBESE RATS; CELLS; STRESS; LKB1; INFLAMMATION; VASODILATION
AB Salidroside (SAL) is a phenylpropanoid glycoside isolated from the medicinal plant Rhodiola rosea. A recent study has reported that SAL can efficiently decrease atherosclerotic plaque formation in low-density lipoprotein receptor-deficient mice. This study was to investigate the molecular mechanism of antiatherogenic effects of SAL Given the importance of endothelial nitric oxide synthase (eNOS) in atherosclerosis, we sought to elucidate whether SAL could stimulate eNOS activation and also to explore its upstream signaling pathway. Six-week old apoE(-/-) male mice were fed a high-fat diet for 8 weeks and then were administered with SAL for another 8 weeks. SAL significantly improved endothelial function associated with increasing eNOS activation, thus reduced the atherosclerotic lesion area. SAL increased eNOS-Ser1177 phosphorylation and decreased eNOS-Thr495 phosphorylation, indicative of eNOS activation in endothelium. The aortic sinus lesions in SAL treated mice displayed reduced inflammation. SAL significantly activated AMP-activated protein kinase (AMPK). Both AMPK inhibitor and AMPK small interfering RNA (siRNA) abolished SAL-induced Akt-Ser473 and eNOS-Ser1177 phosphorylation. In contrast LY294002, the PI3k/Akt pathway inhibitor, abolished SAL-induced phosphorylation and expression of eNOS. High performance liquid chromatography (HPLC) analysis revealed that SAL decreased cellular ATP content and increased the cellular AMP/ATP ratio, which was associated with the activation of AMPK SAL was found to decrease the mitochondrial membrane potential (Delta Psi m), which is a likely consequence of reduced ATP production. The action of SAL to reduce atherosclerotic lesion formation may at least be attributed to its effect on improving endothelial function by promoting nitric oxide (NO) production, which was associated with mitochondrial depolarization and subsequent activation of the AMPK/PI3K/Akt/eNOS pathway. Taken together, our data described the effects of SAL on mitochondria, which played critical roles in improving endothelial function in atherosclerosis. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Xing, Sha-Sha; Yang, Xiao-Yan; Zheng, Tao; Li, Wen Jing; Wu, Dan; Chi, Jiang-Yang; Bian, Fang; Bai, Xiang-Li; Wu, Guang-Jie; Zhang, You-Zhi; Zhang, Cun-Tai; Zhang, Yong-Hui; Li, Yong-Sheng; Jin, Si] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Basic Med, Dept Pharmacol, Wuhan 430030, Peoples R China.
   [Xing, Sha-Sha; Yang, Xiao-Yan; Zheng, Tao; Li, Wen Jing; Wu, Dan; Chi, Jiang-Yang; Bian, Fang; Bai, Xiang-Li; Wu, Guang-Jie; Zhang, You-Zhi; Zhang, Cun-Tai; Zhang, Yong-Hui; Li, Yong-Sheng; Jin, Si] Key Lab Drug Target Res & Pharmacodynam Evaluat H, Wuhan 430030, Peoples R China.
   [Jin, Si] Huazhong Univ Sci & Technol, Tongji Med Coll, Liyuan Hosp, Dept Endocrinol,Inst Geriatr Med, Wuhan 430077, Peoples R China.
C3 Huazhong University of Science & Technology; Huazhong University of
   Science & Technology
RP Jin, S (corresponding author), Huazhong Univ Sci, Inst Geriatr Med, Tongji Med Coll, Dept Pharmacol,Sch Basic Med,Dept Endocrinol,Liyu, Wuhan 430030, Peoples R China.
EM Jinsi@mail.hust.edu.cn
RI ; Zhang, Yonghui/AGY-9072-2022; xing, shasha/JFB-2393-2023; jin,
   si/KGK-5977-2024; Zheng, Tao/JOZ-1467-2023
OI Li, Yongsheng/0000-0003-2175-9449; jin, si/0000-0003-0727-6715; Zheng,
   Tao/0000-0003-1742-1357
FU National Natural Science Foundation of China [81470458, 81373413,
   81072634, 81070190]; Ministry of Education of China [NCET-10-0409,
   2013YGYL008]; National Science and Technology Major Projects
   [2013zx09103-001-020, 2011zx09102-004-001]
FX This work was supported by grants from the National Natural Science
   Foundation of China [81470458, 81373413, 81072634, 81070190]; the
   Ministry of Education of China [NCET-10-0409, 2013YGYL008]; and the
   National Science and Technology Major Projects [2013zx09103-001-020,
   2011zx09102-004-001].
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Z9 101
U1 1
U2 68
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA 360 PARK AVE SOUTH, NEW YORK, NY 10010-1710 USA
SN 1537-1891
EI 1879-3649
J9 VASC PHARMACOL
JI Vasc. Pharmacol.
PD SEP
PY 2015
VL 72
BP 141
EP 152
DI 10.1016/j.vph.2015.07.004
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CQ0XU
UT WOS:000360322700016
PM 26187353
DA 2026-05-27
ER

PT J
AU Gülcemal, D
   Alankus-Çaliskan, Ö
   Karaalp, C
   Örs, AU
   Ballar, P
   Bedird, E
AF Gulcemal, Derya
   Alankus-Caliskan, Ozgen
   Karaalp, Canan
   Ors, Ahmet Uygar
   Ballar, Petek
   Bedird, Erdal
TI Phenolic Glycosides with antiproteasomal activity from Centaurea
   urvillei DC. subsp urvillei
SO CARBOHYDRATE RESEARCH
LA English
DT Article
DE Centaurea; Phenolic glycosides; Flavonoids; Structure elucidation;
   Antiproteasomal activity
ID PROTEASOME INHIBITORS; MULTIPLE-MYELOMA; CANCER-THERAPY; MCF-7 CELLS;
   FLAVONOIDS; APOPTOSIS; METABOLITES; EXPRESSION; KAEMPFEROL; TARGET
AB A new flavanone glycoside, naringenin-7-O-beta-D-glucuronopyranoside, and a new flavonol glycoside, 6-hydroxykaempferol-7-O-beta-D-glucuronopyranoside were isolated together with 12 known compounds, 5 flavone glycoside; hispidulin-7-O-beta-D-glucuronopyranoside, apigenin-7-O-beta-D-methylglucuronopyranoside, hispidulin-7-O-beta-D-methylglucuronopyranoside, hispidulin-7-O-beta-D-glucopyranoside, apigenin-7-O-beta-D-glucopyranoside, a flavonol; kaempferol, two flavone; apigenin, and luteolin, a flavanone glycoside; eriodictyol-7-O-beta-D-glucuronopyranoside, and three phenol glycoside; arbutin, salidroside, and 3,5-dihydroxyphenethyl alcohol-3-O-beta-D-glucopyranoside from Centaurea urvillei subsp. urvillei. The structure elucidation of the new compounds was achieved by a combination of one- (H-1 and C-13) and two-dimensional NMR techniques (G-COSY, G-HMQC, and G-HMBC) and LC-ESI-MS. The isolated compounds were tested for their antiproteasomal activity. The results indicated that kaempferol, a well known and widely distributed flavonoid in the plant kingdom, was the most active antiproteasomal agent, followed by apigenin, eriodictyol-7-O-beta-D-glucuronopyranoside, 3,5-dihydroxyphenethyl alcohol-3-O-beta-D-glucopyranoside, and salidroside, respectively. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Bedird, Erdal] Ege Univ, Fac Engn, Dept Bioengn, TR-35100 Izmir, Turkey.
   [Gulcemal, Derya; Alankus-Caliskan, Ozgen] Ege Univ, Fac Sci, Dept Chem, TR-35100 Izmir, Turkey.
   [Karaalp, Canan] Ege Univ, Fac Pharm, Dept Pharmaceut Bot, TR-35100 Izmir, Turkey.
   [Ors, Ahmet Uygar; Ballar, Petek] Ege Univ, Fac Pharm, Dept Biochem, TR-35100 Izmir, Turkey.
C3 Ege University; Ege University; Ege University; Ege University
RP Bedird, E (corresponding author), Ege Univ, Fac Engn, Dept Bioengn, TR-35100 Izmir, Turkey.
EM erdal.bedir@ege.edu.tr
RI Bedir, Erdal/ABI-3895-2020; /AAG-5574-2021; Ballar, Petek/Y-6869-2018;
   karaalp, canan/JQV-8163-2023; /AAH-3385-2021
OI Bedir, Erdal/0000-0003-1262-063X; Ballar, Petek/0000-0002-6189-1818; 
FU TUBITAK [106S197]; TUBA-GEBIP
FX We thank to Dr. Serdar Senol for collection of the plant material and
   Mustafa Ulgey for his assistance in biological assays. This research is
   supported by TUBITAK (project number: 106S197). P.B. is supported by
   TUBA-GEBIP.
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   [No title captured]
   [No title captured]
NR 37
TC 24
Z9 28
U1 1
U2 61
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0008-6215
J9 CARBOHYD RES
JI Carbohydr. Res.
PD NOV 22
PY 2010
VL 345
IS 17
BP 2529
EP 2533
DI 10.1016/j.carres.2010.09.002
PG 5
WC Biochemistry & Molecular Biology; Chemistry, Applied; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Biochemistry & Molecular Biology; Chemistry
GA 684AX
UT WOS:000284520500015
PM 20937505
DA 2026-05-27
ER

PT J
AU Kong, YH
   Xu, SP
AF Kong, Ying-Hui
   Xu, Su-Ping
TI Salidroside prevents skin carcinogenesis induced by DMBA/TPA in a mouse
   model through suppression of inflammation and promotion of apoptosis
SO ONCOLOGY REPORTS
LA English
DT Article
DE salidroside; skin cancer; inflammation; NF-kappa B; apoptosis
ID HEPATOCELLULAR-CARCINOMA CELLS; KAPPA-B PATHWAY; DOWN-REGULATION;
   SIGNALING PATHWAY; EPITHELIAL-CELLS; DNA-DAMAGE; IN-VITRO; CANCER;
   ACTIVATION; EXPRESSION
AB Salidroside (SR) is a main component of Rhodiola rosea L. and exhibits a variety of pharmacologic properties. The present study was carried out to explore the potential effect of SR against skin cancer induced by 7,12-dimethylbenz(a) anthracene (DMBA) and 12-O-tetradecanoylphorbol-13-acetate (TPA) in female Institute for Cancer Research (ICR) mice and to reveal the underlying molecular targets regulated by SR. The mice were randomly divided into 4 groups: control, DMBA/TPA, DMBA/TPA+SR (20 mg/kg) and DMBA/TPA+SR (40 mg/kg). SR was administered to mice five times a week after DMBA treatments. In our study, we found that SR dose-dependently ameliorated skin cancer incidence and the multiplicity in the animal models by reducing the release of inflammation-related cytokines, including tumor necrosis factor alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), interleukin-18 (IL-18), interleukin-6 (IL-6), cyclooxygenase 2 (COX2) and transforming growth factor beta-1 (TGF-beta 1). Suppression of the nuclear factor (NF)-kappa B signaling pathway by SR was effective to prevent skin carcinogenesis. Furthermore, TUNEL analysis indicated that compared to the DMBA/TPA group, enhanced apoptosis was observed in the DMBA/TPA+SR group. In addition, p53 expression levels were increased by SR in the DMBA/TPA-induced mice. Therefore, SR was effective for inducing apoptosis during skin cancer progression triggered by DMBA/TPA. Consistently, p21, p53 upregulated modulator of apoptosis (PUMA), Bax and caspase-3 were highly induced by SR to enhance the apoptotic response for preventing skin cancer. Moreover, in vitro, we found that SR dramatically reduced the inflammatory response, while enhancing the aoptotic response by blocking NF-kappa B and activating caspase-3 pathways, respectively. In addition, flow cytometric analysis further confirmed the induction of apoptosis by SR in DMBA-treated cells in vitro. Taken together, the in vivo and in vitro studies illustrated that SR might be a promising compound to reduce skin cancer risk.
C1 [Kong, Ying-Hui; Xu, Su-Ping] Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Dermatol, 6 Beijing Rd West, Huaian 223300, Jiangsu, Peoples R China.
C3 Nanjing Medical University
RP Kong, YH (corresponding author), Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Dermatol, 6 Beijing Rd West, Huaian 223300, Jiangsu, Peoples R China.
EM kongyinghuinmuu@foxmail.com
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NR 70
TC 50
Z9 55
U1 0
U2 18
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1021-335X
EI 1791-2431
J9 ONCOL REP
JI Oncol. Rep.
PD JUN
PY 2018
VL 39
IS 6
BP 2513
EP 2526
DI 10.3892/or.2018.6381
PG 14
WC Oncology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology
GA GF8SA
UT WOS:000432241900005
PM 29693192
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhu, MR
   Shang, YX
   Zhao, MJ
   Liu, J
   Wang, FY
   Zou, W
   Wang, B
   Liu, LK
   Liu, J
AF Zhu, Mengru
   Shang, Yuxuan
   Zhao, Mingjian
   Liu, Jia
   Wang, Fengya
   Zou, Wei
   Wang, Bing
   Liu, Lukuan
   Liu, Jing
TI Multi-omics profiling identifies berberine and salidroside as potential
   immunoregulatory compounds in radiation-induced skin injury
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE radiation-induced skin injury; fibroblast; apoptosis; TGF-beta; drug
   targets; immunotherapy
ID IRRADIATION; APOPTOSIS; FIBROSIS; PATHWAY
AB Background Radiation-induced skin injury is a significant concern in nuclear accidents and cancer radiotherapy (RT). Skin damage ranges from mild erythema to severe ulceration, which significantly affects the patients' quality of life. While previous studies have highlighted the role of the apoptotic pathway, its precise mechanism in radiation-induced skin damage remains unclear.Method First, single-cell RNA and RNA-seq datasets were searched using the Gene Expression Omnibus (GEO) database, and further subgroup analysis of fibroblast skin cells, pseudotime analysis, and cell-cell communication analysis were conducted to determine the important state during fibroblast differentiation. Next, we analyzed and screened the key genes in the RNA-seq data. Finally, we performed SA-beta-gal staining, flow cytometry, and qRT-PCR in an in vitro irradiation model to validate TGFBR2 as a potential therapeutic target.Result The apoptotic pathway plays a crucial role in fibroblasts. Subsequent analysis of fibroblast subtypes revealed different subtypes, including MMP3, Coch, Apod, and Eif4e. Enrichment analysis further demonstrated a significant upregulation of apoptosis in MMP3 fibroblasts (FIB). Pseudotime analysis indicated that MMP3 FIB exhibited high stemness within the fibroblast differentiation trajectory, while intercellular communication analysis underscored the critical role of TGF-beta in fibroblast subtype interactions. Additionally, RNA-Seq analysis identified TGFBR2 as a key gene. In vitro experiments corroborated the essential function of TGFBR2 in radiation-induced skin injury. Lastly, molecular docking studies identified potential therapeutic agents, including Berberine and Salidroside.Conclusion This study integrates single-cell and bulk transcriptomic analyses to reveal apoptosis-sensitive fibroblast subtypes involved in radiation-induced skin injury. MMP3+ fibroblasts were identified as a key apoptotic population with high stemness potential, and TGFBR2 was validated as a central regulatory target through molecular and cellular assays. Furthermore, Berberine and Salidroside were identified via molecular docking as potential compounds targeting TGFBR2. These findings provide mechanistic insight into fibroblast heterogeneity under radiation stress and offer a foundation for targeted therapeutic strategies.
C1 [Zhu, Mengru; Liu, Jia; Wang, Fengya; Liu, Lukuan; Liu, Jing] Dalian Med Univ, Stem Cell Clin Res Ctr, Affiliated Hosp 1, Dalian, Liaoning, Peoples R China.
   [Zhu, Mengru; Shang, Yuxuan; Zhao, Mingjian] Dalian Med Univ, Dept Plast Surg, Affiliated Hosp 1, Dalian, Peoples R China.
   [Liu, Jia; Zou, Wei; Liu, Jing] Dalian Innovat Inst Stem Cell & Precis Med, Liaoning Key Lab Frontier Technol Stem Cell & Prec, Dalian, Peoples R China.
   [Wang, Bing] Dalian Med Univ, Dept Radiat Oncol, Affiliated Hosp 1, Dalian, Peoples R China.
C3 Dalian Medical University; Dalian Medical University; Dalian Medical
   University
RP Liu, LK; Liu, J (corresponding author), Dalian Med Univ, Stem Cell Clin Res Ctr, Affiliated Hosp 1, Dalian, Liaoning, Peoples R China.; Liu, J (corresponding author), Dalian Innovat Inst Stem Cell & Precis Med, Liaoning Key Lab Frontier Technol Stem Cell & Prec, Dalian, Peoples R China.
EM lukuanliu@163.com; liujing@dmu.edu.cn
RI Liu, Lukuan/GMW-5007-2022; yuxuan, shang/PVE-3240-2026
FU National Natural Science Foundation of China [22004012]; DICP [DICP
   UN202204]; Liaoning Directed Project for Planning of Science and
   Technology [2021JH2/10300135]; Dalian High-level Talent Team Project
   [2022RG18, 2024RQ003]; Natural Science Foundation of Liaoning Province
   [2023-BSBA-098]
FX The author(s) declare financial support was received for the research
   and/or publication of this article. This study was supported by the
   National Natural Science Foundation of China (No. 22004012), and
   DMU-1&DICP (DMU-1&DICP UN202204) from Lukuan Liu, Liaoning Directed
   Project for Planning of Science and Technology (No.
   2021JH2/10300135),and Dalian High-level Talent Team Project (No.
   2022RG18) from Jing Liu, Dalian Science and Technology Talent Innovation
   Support Program Project(2024RQ003) from Mengru Zhu, and Natural Science
   Foundation of Liaoning Province (No. 2023-BSBA-098)from Fengya Wang.
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NR 53
TC 0
Z9 0
U1 5
U2 9
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD SEP 18
PY 2025
VL 16
AR 1666549
DI 10.3389/fimmu.2025.1666549
PG 16
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 8CG8O
UT WOS:001585243200001
PM 41050697
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Gao, MT
   Xue, X
   Zhang, XM
   Chang, YY
   Zhang, QL
   Li, X
   Wang, YF
   Zhang, L
   Li, ZP
   Dong, HJ
   Wang, W
   Yao, WF
AF Gao, Mengting
   Xue, Xin
   Zhang, Xuemeng
   Chang, Yueyue
   Zhang, Qiulan
   Li, Xin
   Wang, Yifei
   Zhang, Li
   Li, Zhipeng
   Dong, Haijuan
   Wang, Wei
   Yao, Weifeng
TI Discovery of potential active ingredients of Er-Zhi-Wan, a famous
   traditional Chinese formulation, in model rat serum for treating
   osteoporosis with kidney-yin deficiency by UPLC-Q/TOF-MS and molecular
   docking
SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL
   AND LIFE SCIENCES
LA English
DT Article
DE Chinese herbal medicine; Constituents absorbed into blood; Differential
   metabolites; Liquid chromatography -mass spectrometry; Potential active
   ingredients
ID HERBAL PREPARATION; LIGUSTRI-LUCIDI; PHYTOCHEMISTRY; CONSTITUENTS;
   PHARMACOLOGY; SALIDROSIDE; PERFORMANCE; MEDICINE; FRUCTUS
AB Er-Zhi-Wan (EZW), a classical traditional Chinese formulation, has attracted more and more attention. This study was carried out to analyze the constituents of EZW absorbed into blood and find out the potential active in-gredients for treating osteoporosis (OP) with kidney-yin deficiency (KYD). The rat model of OP with KYD was achieved by ovariectomies and using the mixture of thyroxine and reserpine. Then ultra-high performance liquid chromatography coupled with a quadrupole time-of-flight mass spectrometer (UPLC-Q/TOF-MS) combined with statistical analysis was used to analyze the constituents of EZW absorbed into blood and differential components between the normal and OP with KYD rats. Finally, the components identified in OP with KYD rats were docked with targets of OP with KYD found in online databases. The results of molecular docking were adopted to find the potential active ingredients and further verified in vitro experiment. A total of 21 prototype compounds and 69 metabolites were identified in serum. Among them, 63 components in model rats and 50 components in normal rats were summarized, respectively. Most of the identified metabolites in serum of model rats were produced by hydrolysis, oxidation or glucuronidation, while in serum of normal rats were produced by hydrolysis, oxidation and methylation. According to the results of molecular docking, specnuezhenide, salidroside, tyrosol, echina-coside and verbascoside could be classified as potential active ingredients. The activity of salidroside and a metabolite was verified by pharmacodynamics analysis. In summary, UPLC-Q/TOF-MS system was combined with molecular docking to search the potential active ingredients from model rats of OP with KYD, which provided a new idea for the research on the pharmacodynamic material basis of other traditional medicine. Moreover, the result of this study lays the foundation for further study regarding the mechanism of EZW in treating OP with KYD.
C1 [Gao, Mengting; Xue, Xin; Zhang, Xuemeng; Chang, Yueyue; Zhang, Qiulan; Li, Xin; Wang, Yifei; Zhang, Li; Yao, Weifeng] Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Jiangsu, Peoples R China.
   [Gao, Mengting; Xue, Xin; Zhang, Xuemeng; Chang, Yueyue; Zhang, Qiulan; Li, Xin; Wang, Yifei; Zhang, Li; Yao, Weifeng] Jiangsu Collaborat Innovat Ctr Chinese Med Resourc, Nanjing 210023, Jiangsu, Peoples R China.
   [Gao, Mengting; Xue, Xin; Zhang, Xuemeng; Chang, Yueyue; Zhang, Qiulan; Li, Xin; Wang, Yifei; Zhang, Li; Yao, Weifeng] Natl & Local Collaborat Engn Ctr Chinese Med Resou, Nanjing 210023, Jiangsu, Peoples R China.
   [Li, Zhipeng] Nanjing Med Univ, Jiangsu Canc Hosp, Nanjing 210009, Jiangsu, Peoples R China.
   [Li, Zhipeng] Nanjing Med Univ, Jiangsu Inst Canc Res, Nanjing 210009, Jiangsu, Peoples R China.
   [Li, Zhipeng] Nanjing Med Univ, Affiliated Canc Hosp, Nanjing 210009, Jiangsu, Peoples R China.
   [Dong, Haijuan] China Pharmaceut Univ, Publ Lab Platform, Nanjing 210009, Jiangsu, Peoples R China.
   [Wang, Wei] Nanjing Univ Chinese Med, Affiliated Hosp, Dept Gynecol, Nanjing, Jiangsu, Peoples R China.
   [Li, Zhipeng; Yao, Weifeng] Nanjing Univ Chinese Med, Sch Pharm, Nanjing, Peoples R China.
C3 Nanjing University of Chinese Medicine; Nanjing Medical University;
   Nanjing Medical University; Nanjing Medical University; China
   Pharmaceutical University; Nanjing University of Chinese Medicine;
   Nanjing University of Chinese Medicine
RP Yao, WF (corresponding author), Jiangsu Collaborat Innovat Ctr Chinese Med Resourc, Nanjing 210023, Jiangsu, Peoples R China.; Li, ZP (corresponding author), Nanjing Med Univ, Jiangsu Canc Hosp, Nanjing 210009, Jiangsu, Peoples R China.; Li, ZP; Yao, WF (corresponding author), Nanjing Univ Chinese Med, Sch Pharm, Nanjing, Peoples R China.
EM lizhipeng@njmu.edu.cn; yaowf@njucm.edu.cn
RI Yao, Weifeng/I-7394-2013
FU National Natural Science-Foundation of China [81973445, 81904236];
   Graduate Research and Innovation Projects of Jiangsu Province
   [KYCX21_1807, KYCX21_1730, KYCX21_1806]
FX This work was financially supported by National Natural
   Science-Foundation of China (Grant No. 81973445, 81904236) . This
   research was also supported by Graduate Research and Innovation Projects
   of Jiangsu Province (KYCX21_1807, KYCX21_1730 and KYCX21_1806) .
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NR 61
TC 14
Z9 14
U1 7
U2 56
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1570-0232
EI 1873-376X
J9 J CHROMATOGR B
JI J. Chromatogr. B
PD OCT 1
PY 2022
VL 1208
AR 123397
DI 10.1016/j.jchromb.2022.123397
EA JUL 2022
PG 13
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 5A2CU
UT WOS:000862700900011
PM 35921699
DA 2026-05-27
ER

PT J
AU Ding, XJ
   Zhang, ZY
   Jin, J
   Han, JX
   Wang, Y
   Yang, K
   Yang, YY
   Wang, HQ
   Dai, XT
   Yao, C
   Sun, T
   Zhu, CB
   Liu, HJ
AF Ding, Xiu-Juan
   Zhang, Zhi-Yuan
   Jin, Jing
   Han, Jing-Xia
   Wang, Yan
   Yang, Kai
   Yang, Yu-Yan
   Wang, Hong-Qi
   Dai, Xin-Tong
   Yao, Cheng
   Sun, Tao
   Zhu, Cai-Bin
   Liu, Hui-Juan
TI Salidroside can target both P4HB-mediated inflammation and melanogenesis
   of the skin
SO THERANOSTICS
LA English
DT Article
DE Salidroside; tyrosinase; prolyl 4-hydroxylase beta polypeptide (P4HB);
   interferon regulatory factor 1 (IRF1); upstream stimulatory factor 1
   (USF1)
ID RHODIOLA-ROSEA L.; TRANSCRIPTION FACTOR; MELANIN SYNTHESIS; TYROSINASE;
   CELLS; SUN; EXPRESSION; EXPOSURE; EXTRACT
AB Rationale: Many external factors can induce the melanogenesis and inflammation of the skin. Salidroside (SAL) is the main active ingredient of Rhodiola, which is a perennial grass plant of the Family Crassulaceae. This study evaluated the effect and molecular mechanism of SAL on skin inflammation and melanin production. It then explored the molecular mechanism of melanin production under ultraviolet (UV) and inflammatory stimulation.
   Methods: VISIA skin analysis imaging system and DermaLab instruments were used to detect the melanin reduction and skin brightness improvement rate of the volunteers. UV-treated Kunming mice were used to detect the effect of SAL on skin inflammation and melanin production. Molecular docking and Biacore were used to verify the target of SAL. Immunofluorescence, luciferase reporter assay, CO-IP, pull-down, Western blot, proximity ligation assay (PLA), and qPCR were used to investigate the molecular mechanism by which SAL regulates skin inflammation and melanin production.
   Results: SAL can inhibit the inflammation and melanin production of the volunteers. SAL also exerted a protective effect on the UV-treated Kunming mice. SAL can inhibit the tyrosinase (TYR) activity and TYR mRNA expression in A375 cells. SAL can also regulate the ubiquitination degradation of interferon regulatory factor 1 (IRF1) by targeting prolyl 4-hydroxylase beta polypeptide (P4HB) to mediate inflammation and melanin production. This study also revealed that IRF1 and upstream stimulatory factor 1 (USF1) can form a transcription complex to regulate TYR mRNA expression. IRF1 also mediated inflammatory reaction and TYR expression under UV- and lipopolysaccharide-induced conditions. Moreover, SAL derivative SAL-plus (1-(3,5-dihydroxyphenyl) ethyl-beta-d-glucoside) showed better effect on inflammation and melanin production than SAL.
   Conclusion: SAL can inhibit the inflammation and melanogenesis of the skin by targeting P4HB and regulating the formation of the IRF1/USF1 transcription complex. In addition, SAL-plus may be a new melanin production and inflammatory inhibitor.
C1 [Ding, Xiu-Juan; Zhang, Zhi-Yuan; Jin, Jing; Yang, Kai; Yao, Cheng; Zhu, Cai-Bin] Cheermore Cosmet Dermatol Lab, Shanghai, Peoples R China.
   [Han, Jing-Xia; Yang, Yu-Yan; Wang, Hong-Qi; Dai, Xin-Tong; Sun, Tao; Liu, Hui-Juan] Tianjin Int Joint Acad Biomed, Tianjin Key Lab Early Druggabil Evaluat Innovat D, Tianjin, Peoples R China.
   [Ding, Xiu-Juan; Yang, Yu-Yan; Wang, Hong-Qi; Dai, Xin-Tong; Sun, Tao; Liu, Hui-Juan] Nankai Univ, State Key Lab Med Chem Biol, Tianjin, Peoples R China.
   [Ding, Xiu-Juan; Yang, Yu-Yan; Wang, Hong-Qi; Dai, Xin-Tong; Sun, Tao; Liu, Hui-Juan] Nankai Univ, Coll Pharm, Tianjin, Peoples R China.
   [Sun, Tao] Tianjin Med Univ, Gen Hosp, Tianjin Inst Digest Dis, Dept Gastroenterol & Hepatol, Tianjin, Peoples R China.
   [Wang, Yan] Shijiazhuang Food & Drug Inspect Ctr, Qual Management Dept, Shijiazhuang, Hebei, Peoples R China.
C3 Tianjin International Joint Academy of Biomedicine; Nankai University;
   Nankai University; Tianjin Medical University
RP Zhu, CB (corresponding author), Cheermore Cosmet Dermatol Lab, Shanghai, Peoples R China.; Sun, T; Liu, HJ (corresponding author), Tianjin Int Joint Acad Biomed, Tianjin Key Lab Early Druggabil Evaluat Innovat D, Tianjin, Peoples R China.; Sun, T; Liu, HJ (corresponding author), Nankai Univ, State Key Lab Med Chem Biol, Tianjin, Peoples R China.; Sun, T; Liu, HJ (corresponding author), Nankai Univ, Coll Pharm, Tianjin, Peoples R China.; Sun, T (corresponding author), Tianjin Med Univ, Gen Hosp, Tianjin Inst Digest Dis, Dept Gastroenterol & Hepatol, Tianjin, Peoples R China.
EM tao.sun@nankai.edu.cn; alex@cheermorecos.com; liuhuijuanxyz@163.com
FU Tianjin Science and Technology Project [18PTSYJC00060]; Innovative
   Technology Project of Cosmetic Dermatology Laboratory
FX This study was founded by the Tianjin Science and Technology Project
   (Grant no. 18PTSYJC00060) and the Innovative Technology Project of
   Cosmetic Dermatology Laboratory.
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NR 27
TC 49
Z9 56
U1 4
U2 82
PU IVYSPRING INT PUBL
PI LAKE HAVEN
PA PO BOX 4546, LAKE HAVEN, NSW 2263, AUSTRALIA
SN 1838-7640
J9 THERANOSTICS
JI Theranostics
PY 2020
VL 10
IS 24
BP 11110
EP 11126
DI 10.7150/thno.47413
PG 17
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA NU5FG
UT WOS:000573666500004
PM 33042273
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, GS
   Wang, W
   Guo, H
   Yi, SY
   Wang, F
   Huang, SP
   Hu, N
   Xu, QL
   Zang, YJ
   Han, BX
   Yin, XJ
AF Li, Guosi
   Wang, Wei
   Guo, Heng
   Yi, Shanyong
   Wang, Fang
   Huang, Shiping
   Hu, Nan
   Xu, Qilin
   Zang, Yongjun
   Han, Bangxing
   Yin, Xinjian
TI Mutability landscape guided engineering of a promiscuous microbial
   glycosyltransferase for regioselective synthesis of salidroside and
   icariside D2
SO INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
LA English
DT Article
DE Glucosides; Directed evolution; Glycosyltransferase; Regioselectivity
ID PHENOLIC GLUCOSIDES
AB Microbial glycosyltransferases efficiently synthesize glucosides and have garnered increasing interest. However, limited regioselectivity has impeded their broad application, particularly in the pharmaceutical industry. In this study, the UDP-glycosyltransferase YjiC from Bacillus licheniformis (BlYjiC) was engineered to achieve the bidirectional regioselective glycosylation of tyrosol and its derivatives. Initially, site-directed saturation mutagenesis was performed on two newly identified substrate-binding cavities in the acceptor pocket of BlYjiC to provide a comprehensive blueprint of the interplay between mutations and function (mutability landscape). Iterative saturation mutagenesis was performed, guided by the mutability landscape. Two highly regioselective mutants M6 (M112L/I325Y/L70R/Q136E/I67E/M77R) and M2' (M112D/I62L) were generated, exhibiting >99 % regioselectivity toward the alcoholic and phenolic hydroxyl of tyrosol, respectively, compared with the wild -type (product mixture: 51:49 %). Both mutants exhibited excellent regioselectivity toward several dihydroxy phenolic substrates, offering valuable biocatalysts for the regioselective synthesis of glucosides. Their application was confirmed in a short synthesis of salidroside (3.6 g/L) and icariside D2 (2.4 g/L), which exhibited near-perfect regioselectivity. This study provides valuable insights into future protein engineering of similar enzymes and opens new avenues for their practical applications.
C1 [Li, Guosi; Wang, Wei; Yi, Shanyong; Wang, Fang; Huang, Shiping; Hu, Nan; Xu, Qilin; Zang, Yongjun; Han, Bangxing] West Anhui Univ, Gener Technol Res Ctr Anhui Tradit Chinese Med Ind, Anhui Engn Lab Conservat & Sustainable Utilizat Tr, Luan 237012, Anhui, Peoples R China.
   [Guo, Heng; Yin, Xinjian] Sun Yat Sen Univ, Sch Marine Sci, Zhuhai 519080, Peoples R China.
   [Han, Bangxing] Tradit Chinese Med Inst Anhui Dabie Mt, Anhui Engn Res Ctr Ecoagr Tradit Chinese Med, Luan 237012, Anhui, Peoples R China.
C3 West Anhui University; Sun Yat Sen University
RP Yin, XJ (corresponding author), Sun Yat Sen Univ, Sch Marine Sci, Zhuhai 519080, Peoples R China.
EM yinxj5@mail.sysu.edu.cn
RI Huang, Shiping/AAT-7270-2021
FU National Natural Science Foundation of China [22108317]; Guangdong Basic
   and Applied Basic Research Foundation [2021A1515010829]; Natural Science
   Foundation of Higher Education Institutions of Anhui Province
   [2023AH052649]; Open Fund of Anhui Engineering Laboratory for
   Conservation and Sustainable Utilization of Traditional Chinese Medi-
   cine Resources [TCMRPSU-2022-03]; Fund of Generic Technology Research
   Centre for Anhui Traditional Chinese Medicine Industry
   [AHTCMGTRC-2023-09]; China Agriculture Research System of MOF and MARA
FX This work was financially supported by the National Natural Science
   Foundation of China (No. 22108317), the Guangdong Basic and Applied
   Basic Research Foundation (2021A1515010829), the Natural Science
   Foundation of Higher Education Institutions of Anhui Province
   (2023AH052649), the Open Fund of Anhui Engineering Laboratory for
   Conservation and Sustainable Utilization of Traditional Chinese Medicine
   Resources (TCMRPSU-2022-03), the Fund of Generic Technology Research
   Centre for Anhui Traditional Chinese Medicine Industry
   (AHTCMGTRC-2023-09), and the China Agriculture Research System of MOF
   and MARA.
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NR 34
TC 15
Z9 18
U1 6
U2 87
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0141-8130
EI 1879-0003
J9 INT J BIOL MACROMOL
JI Int. J. Biol. Macromol.
PD APR
PY 2024
VL 263
AR 130229
DI 10.1016/j.ijbiomac.2024.130229
EA FEB 2024
PN 1
PG 10
WC Biochemistry & Molecular Biology; Chemistry, Applied; Polymer Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Polymer Science
GA LT0E5
UT WOS:001188927300001
PM 38378110
DA 2026-05-27
ER

PT J
AU Khanna, K
   Mishra, KP
   Ganju, L
   Singh, SB
AF Khanna, Kunjan
   Mishra, K. P.
   Ganju, Lilly
   Singh, Shashi Bala
TI Golden root: A wholesome treat of immunity
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Review
DE Rhodiola; Immunity; Rhizome; NK cell; Antiviral
ID RHODIOLA-IMBRICATA RHIZOME; AQUEOUS EXTRACT; SALIDROSIDE PROTECTS;
   CHEMICAL-COMPOSITION; RAT MODEL; ROSEA L.; KAPPA-B; CRASSULACEAE;
   CANCER; PLANTS
AB Rhodiola is native to the high altitude regions of Asia, Europe and Northern Hemisphere. It has a long history of use as a medicinal plant in various ailments, boosting immunity, increasing energy and mental capacity. It is also known as "Adaptogen" to help the body to adapt and resist stress. The part of the plant, which is used for medicinal values, is rhizome, which is an underground stem. The rhizome contains mainly salidroside, rosin, rosavin and p-tyrosol. There are many studies, which have reported the effects of Rhodiola spp. on different organs and health conditions. In this review, we have selected the articles from Pubmed and Google Scholar from year 1992-2016 to report the effects of Rhodiola spp. and their role in curtailing various diseases and stress. The present review emphasizes the medicinal and therapeutic applications of Rhodiola spp. on different experimental models. Overall conclusion is that Rhodiola spp. has immense therapeutic potential and hence, this review would give impetus to new research for the development of Rhodiola based herbal nutraceuticals as well as pharmaceuticals. (C) 2017 Elsevier Masson SAS. All rights reserved.
C1 [Khanna, Kunjan; Mishra, K. P.; Ganju, Lilly; Singh, Shashi Bala] Def Inst Physiol & Allied Sci, Immunomodulat Lab, Lucknow Rd, Delhi 110054, India.
C3 Defence Research & Development Organisation (DRDO); Defence Institute of
   Physiology & Allied Sciences (DIPAS)
RP Mishra, KP (corresponding author), Def Inst Physiol & Allied Sci, Immunomodulat Lab, Lucknow Rd, Delhi 110054, India.
EM kpmpgi@rediffmail.com
RI ; /AAS-9889-2021; Ganju, Lilly/LZI-4336-2025; Khanna,
   Kunjan/GXF-6332-2022
OI Mishra, KP/0000-0002-8371-3772; 
FU Defence Research and Development Organization, Ministry of Defence,
   Government of India [DIP-265]; DRDO
FX Authors are thankful to the Defence Research and Development
   Organization, Ministry of Defence, Government of India for financial
   support in the form of DIP-265. KK thanks DRDO for the fellowship in the
   form of JRF and SRF.
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NR 74
TC 34
Z9 42
U1 0
U2 50
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD MAR
PY 2017
VL 87
BP 496
EP 502
DI 10.1016/j.biopha.2016.12.132
PG 7
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA EM7XM
UT WOS:000395525600058
PM 28073099
DA 2026-05-27
ER

PT J
AU Yan, T
   Li, X
   Nian, TT
   Zhang, XZ
   He, B
   Bi, KS
   Wang, ZZ
AF Yan, Tingxu
   Li, Xu
   Nian, Tingting
   Zhang, Xiaozhuo
   He, Bosai
   Bi, Kaishun
   Wang, Zhenzhong
TI Salidroside Inhibits Ischemia/Reperfusion-Induced Myocardial Apoptosis
   by Targeting Mir-378a-3p Via the Igf1r/Pi3k/Akt Signaling Pathway
SO TRANSPLANTATION PROCEEDINGS
LA English
DT Article
ID INFARCTION
AB Background. The present study aimed to investigate the protective effects and mechanism of salidroside (SAL) on hypoxia/reoxygenation (H/R)-induced cardiomyocyte apoptosis and myocardial ischemia/reperfusion (I/R) injury.
   Methods. We set up an H/R H9c2 cell model in vitro and an I/R rat model in vivo. Cell viability, apoptosis and histopathologic evaluation were conducted.
   Results. The cell viability of H/R-induced cardiomyocytes was increased by pretreatment of SAL, whereas the release of lactate dehydrogenase, reactive oxygen species production, and apoptosis were decreased accompanied with reduced Cleaved-caspase-3 and Bax, and increased Bcl2 expressions. The SAL restored mitochondrial membrane potential both in vitro and in vivo, and improved electrocardiographic abnormality, and attenuated myocardial apoptosis and injury in I/ R-induced rats. The transfection of miR-378a-3p inhibitor counteracted the effects of SALinduced increase of cell viability and decrease of cell apoptosis and mitochondrial membrane potential. SAL reduced the expression of insulin-like growth factor 1 receptor (IGF1R), and increased the expressions of PI3K and Akt, however, these alterations were blocked by miR378a-3p inhibitor.
   Conclusions. miR-378a-3p might participate in the protective effect of SAL in I/R-induced myocardial apoptosis via the IGF1R/PI3K/AKT signaling pathway.
C1 [Yan, Tingxu; Li, Xu; Wang, Zhenzhong] Jiangsu Kangyuan Pharmaceut Co Ltd, Lianyungang, Peoples R China.
   [Yan, Tingxu; He, Bosai] Shenyang Pharmaceut Univ, School Funct Food & Wine, Shenyang, Peoples R China.
   [Li, Xu; Wang, Zhenzhong] State Key Lab New Tech Chinese Med Pharmaceut Pro, Lianyungang, Jiangsu, Peoples R China.
   [Nian, Tingting; Zhang, Xiaozhuo] Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat Medica, Shenyang, Peoples R China.
   [Bi, Kaishun] Shenyang Pharmaceut Univ, Sch Pharm, Shenyang, Peoples R China.
C3 Shenyang Pharmaceutical University; Shenyang Pharmaceutical University;
   Shenyang Pharmaceutical University
RP Bi, KS (corresponding author), Shenyang Pharmaceut Univ, Sch Pharm, Wenhua Rd 103, Shenyang 110016, Peoples R China.; Wang, ZZ (corresponding author), Jiangsu Kangyuan Pharmaceut Co Ltd, Lianyungang 222047, Peoples R China.
EM 52091475@qq.com; kyyywzz@163.com
RI He, Bosai/OML-7628-2025
FU China Postdoctoral Science Foundation [2020M681518]; National Natural
   Science Foundation of China [82173961]
FX Research on Key technologies of multi-component traditional Chinese
   medicines, Special Funds for transformation and upgrading of industrial
   informatization of industry and information technology department of
   jiangsu in 2020. Project funded by China Postdoctoral Science Foundation
   (2020M681518). This research was supported by National Natural Science
   Foundation of China (No. 82173961).
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NR 27
TC 8
Z9 9
U1 2
U2 7
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0041-1345
EI 1873-2623
J9 TRANSPL P
JI Transplant. Proc.
PD SEP
PY 2022
VL 54
IS 7
BP 1970
EP 1983
DI 10.1016/j.transproceed.2022.05.017
PG 14
WC Immunology; Surgery; Transplantation
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Surgery; Transplantation
GA I8SG3
UT WOS:001005421300039
PM 35927086
OA hybrid
DA 2026-05-27
ER

PT J
AU Shi, YM
   Yao, SD
   Jia, ZJ
   Lin, NY
   Zheng, RL
AF Shi, Yimin
   Yao, Side
   Jia, Zhongjian
   Lin, Nianyun
   Zheng, Rongliang
TI Dietary phytophenols act as scavengers of reducing radicals
SO FOOD CHEMISTRY
LA English
DT Article
DE Phytophenols; Phenylpropanoid glycosides; Pedicularis; Reducing radical;
   Hydrated electron; Reductive stress
ID PULSE-RADIOLYSIS; PHENYLPROPANOID GLYCOSIDES; AQUEOUS-SOLUTION;
   DEOXYRIBONUCLEIC-ACID; IONIZING-RADIATION; IRIDOID GLYCOSIDES; RATE
   CONSTANTS; FAST REPAIR; ETHANOL; ANIONS
AB Verbascoside, pedicularioside A, cistanoside C, salidroside, 6-O-(E)-feruloyl-glucose and 6-O-(E)-p-hydroxycinnamoyl-glucose were isolated from Pedicularis species and other plants. The scavenging activities of these phytophenols towards hydrated electron, the strongest reducing radical, were investigated by pulse radiolysis. With the exception of salidroside, the other phytophenols react with hydrated electrons (e(aq)(-)) at rate constants close to the diffusion-controlled rate (4.9-7.5 x 10(9)M(-1) s(-1)), indicating that these phytophenols are effective e(aq)(-) scavengers. This property is consistent with the phytophenols' ability to quickly repair DNA radical anions. The comparison of the reaction rate constants indicates that the conjugated carbonyl group is essential to the e;(1 scavenging activities, whereas the phenolic hydroxyl groups, which determine the antioxidant capacity, have no significant effect on the e(aq)(-) scavenging activities. We propose that the reducing radical-scavenging activity of the phytophenols is a novel pharmacological mechanism for prevention and treatment of diseases in which reducing radicals play a key role. Our finding provides a criterion for screening the scavengers of reducing radicals. (C) 2010 Elsevier Ltd. All rights reserved.
C1 [Shi, Yimin; Zheng, Rongliang] Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China.
   [Yao, Side; Lin, Nianyun] Chinese Acad Sci, Shanghai Inst Appl Phys, Shanghai 201800, Peoples R China.
   [Jia, Zhongjian] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China.
   [Zheng, Rongliang] Shanghai Municipal Educ Commiss, E Inst, Shanghai 201203, Peoples R China.
C3 Lanzhou University; Chinese Academy of Sciences; Shanghai Institute of
   Applied Physics, CAS; Lanzhou University; Shanghai Municipal Education
   Commission (SHMEC)
RP Zheng, RL (corresponding author), Lanzhou Univ, Sch Life Sci, Lanzhou 730000, Peoples R China.
EM zhengrl@lzu.edu.cn
FU National Natural Science Foundation of China [39270193]; E-Institutes of
   Shanghai Municipal Education Commission [E-04010]
FX This project was supported in part by National Natural Science
   Foundation of China (Project Number: 39270193) and in part by
   E-Institutes of Shanghai Municipal Education Commission (Project Number:
   E-04010). We thank Dr. Meng Kian Tee (University of California, San
   Francisco, CA) for helpful discussion and critical reading of the
   manuscript.
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NR 32
TC 9
Z9 10
U1 0
U2 24
PU ELSEVIER SCI LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND
SN 0308-8146
EI 1873-7072
J9 FOOD CHEM
JI Food Chem.
PD FEB 15
PY 2011
VL 124
IS 4
BP 1322
EP 1327
DI 10.1016/j.foodchem.2010.07.075
PG 6
WC Chemistry, Applied; Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Food Science & Technology; Nutrition & Dietetics
GA 679VR
UT WOS:000284189400005
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Liu, GY
   He, LY
AF Liu, Guoyong
   He, Liyu
TI Salidroside Attenuates Adriamycin-Induced Focal Segmental
   Glomerulosclerosis by Inhibiting the Hypoxia-Inducible Factor-1α
   Expression Through Phosphatidylinositol 3-Kinase/Protein Kinase B
   Pathway
SO NEPHRON
LA English
DT Article
DE Salidroside; Adriamycin nephropathy; Focal segmental glomerulosclerosis;
   Oxidant stress; Inflammatory response; Hypoxia-inducible factor-1a;
   Phosphatidylinositol 3-kinase/protein kinase B pathway
ID INDUCED INJURY; ACTIVATION; INFLAMMATION; ANTIOXIDANT; CONTRIBUTES;
   FSGS; CELL
AB Background: Focal segmental glomerulosclerosis (FSGS) is a common histologic pattern of kidney injury, which may eventually lead to end-stage renal disease. Objectives: Salidroside (SAL, p-hydroxyphenyl-beta-D-glucoside) is an active component isolated from Rhodiolarosea, which has various pharmacological properties including anti-inflammation and antioxidation. SAL may attenuate FSGS, but the underlying mechanism is not clear. Thus, in this study, we focus on the renoprotective role of SAL in FSGS using Adriamycin nephropathy (AN) mouse models. Methods: In C57 BL/6 mice, AN was induced by Adriamycin (10 mg/kg body weight, diluted in normal saline) via a tail vein on day 0. Then they were organized into 6 groups for the animal experiments: AN + saline group; AN + SAL group (40 mg/kg); AN + LY294002 (a selective phosphatidylinositol 3-kinase [PI3K] inhibitors, 50 mg/kg) group; AN + SAL + LY294002 group; AN + YC-1 (a selective hypoxia-inducible factor-1a [HIF-1a] inhibitors, 50 mg/kg) group; and AN + SAL + YC-1 group. All of the drugs were given on the day of Adriamycin injection and continued for 6 weeks, and the drugs were given by intraperitoneally. At 6 weeks, the mice were sacrificed; kidneys and blood samples were collected for further analysis. Results: In FSGS mouse models, SAL treatment could ameliorate proteinuria, renal function, and markers of Nephrotic Syndrome inhibit alpha-smooth muscle actin and fibronectin expression and downregulates the expression of HIF-1a. Besides, the levels of PI3K and p-protein kinase B (Akt) in renal tissues were significantly decreased after SAL injection. Eventually, SAL treatment results reduced inflammatory cytokines and reactive oxygen species production. Conclusions: In summary, SAL ameliorates FSGS mainly by inhibiting the expression of HIF-1a through PI3K/Akt pathway, which might offer an array of hope for ameliorating FSGS. (c) 2019 S. Karger AG, Basel
C1 [He, Liyu] Cent S Univ, Xiangya Hosp 2, Hunan Key Lab Kidney Dis & Blood Purificat, Dept Nephrol, 139 Renmin Rd, Changsha 410011, Hunan, Peoples R China.
   [Liu, Guoyong] Changde Vocat Tech Coll, Affiliated Hosp 1, Dept Nephrol, Changde, Peoples R China.
C3 Central South University
RP He, LY (corresponding author), Cent S Univ, Xiangya Hosp 2, Hunan Key Lab Kidney Dis & Blood Purificat, Dept Nephrol, 139 Renmin Rd, Changsha 410011, Hunan, Peoples R China.
EM heliyu1124@126.com
OI He, Liyu/0000-0002-6637-3729
FU National Natural Science Foundation of China [81870500]; Natural Science
   Foundation of Hunan Province [2017JJ2002];  [20180922]
FX This work was supported by a research grant (81870500) from the National
   Natural Science Foundation of China. It was also supported by research
   grants (2017JJ2002) from the Natural Science Foundation of Hunan
   Province, the Health and Family Planning Commission of Hunan Province
   (20180922).
CR Angioi A, 2016, J NEPHROL, V29, P517, DOI 10.1007/s40620-016-0333-2
   Cai LL, 2017, EUR J PHARMACOL, V806, P32, DOI 10.1016/j.ejphar.2017.04.011
   Chen Y, 2016, RENAL FAILURE, V38, P1726, DOI 10.1080/0886022X.2016.1229994
   Cui JY, 2018, LIFE SCI, V192, P293, DOI 10.1016/j.lfs.2017.11.007
   Guan RJ, 2018, FRONT PHARMACOL, V9, DOI 10.3389/fphar.2018.00263
   Haase VH, 2012, FIBROGENESIS TISSUE, V5, DOI 10.1186/1755-1536-5-S1-S16
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NR 31
TC 15
Z9 18
U1 0
U2 16
PU KARGER
PI BASEL
PA ALLSCHWILERSTRASSE 10, CH-4009 BASEL, SWITZERLAND
SN 1660-8151
EI 2235-3186
J9 NEPHRON
JI Nephron
PY 2019
VL 142
IS 3
BP 243
EP 252
DI 10.1159/000497821
PG 10
WC Urology & Nephrology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Urology & Nephrology
GA II6OA
UT WOS:000475312000006
PM 30840958
DA 2026-05-27
ER

PT J
AU Zhang, X
   Zhu, JL
   Yan, JN
   Xiao, Y
   Yang, RJ
   Huang, RF
   Zhou, J
   Wang, ZZ
   Xiao, W
   Zheng, CL
   Wang, YH
AF Zhang, Xia
   Zhu, Jinglin
   Yan, Jiangna
   Xiao, Yue
   Yang, Ruijie
   Huang, Ruifei
   Zhou, Jun
   Wang, Zhenzhong
   Xiao, Wei
   Zheng, Chunli
   Wang, Yonghua
TI Systems pharmacology unravels the synergic target space and therapeutic
   potential of Rhodiola rosea L. for non-small cell lung cancer
SO PHYTOMEDICINE
LA English
DT Article
DE Non-small cell lung cancer; Rhodiola rosea L.; Systems pharmacology;
   Antitumor; Target
ID TUMOR ANGIOGENESIS; SIGNALING PATHWAY; DRUG DISCOVERY; RISK-FACTORS;
   PROLIFERATION; INFLAMMATION; EPIDEMIOLOGY; MECHANISMS; MIGRATION;
   APOPTOSIS
AB Background: Lung cancer is the most common and mortal cancer worldwide. Rhodiola rosea L. (RR), a well-known traditional Chinese medicine (TCM), has been turned out to be effective in anti-lung cancer therapy, but its molecular mechanism of action has not been clearly understood.
   Purpose: In this study, we aimed to elucidate the possible molecular mechanism underlying the effect of RR against non-small cell lung cancer (NSCLC) by systems pharmacology.
   Methods: The effects of RR on NSCLC were examined in Lewis lung carcinoma (LLC) tumor-bearing mice models. The possible molecular mechanism was unraveled by systems pharmacology, which includes pharmacokinetics evaluation, active compounds screening, target prediction and network analysis. Cell proliferation was examined by cell counting kit-8 (CCK-8) assay; cell apoptosis was detected by flow cytometry; protein and proinflammatory cytokines expression were evaluated by Western blot and qRT-PCR.
   Results: In vivo, RR significantly inhibited the tumor growth and prolonged the survival of the tumor bearing mice. In silico, we identified 19 potential active molecules (e.g., salidroside and rhodiosin), 112 targets (e.g., COX-2 and AKT) and 27 pathways (e.g., PI3K/AKT signaling pathway and NF-kappa B signaling pathway) for RR. Additionally, targets analysis and networks construction further revealed that RR exerted anti-cancer effects by regulating apoptosis, angiogenesis and inflammation. In vitro, salidroside could significantly decrease expression of pro-angiogenic factors (e.g., VEGF and eNOS) and proinflammatory cytokines (e.g., COX-2, iNOS and TNF-alpha). Also, Bcl-2, an anti-apoptotic protein was decreased whereas Box, a pro-apoptotic protein, was increased. Further flow cytometry analysis showed that salidroside could induce apoptosis in H1975 cells.
   Conclusions: Mechanistically, the antitumor effect of RR on NSCLC was responsible for the synergy among anti-inflammatory, anti-angiogenic and pro-apoptotic.
C1 [Zhang, Xia; Zhu, Jinglin; Yan, Jiangna; Xiao, Yue; Yang, Ruijie; Huang, Ruifei; Zheng, Chunli; Wang, Yonghua] Northwest Univ, Sch Life Sci, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, 229 Taibai North Rd, Xian 710069, Shaanxi, Peoples R China.
   [Zhou, Jun; Wang, Zhenzhong; Xiao, Wei] Jiangsu Kanion Parmaceut Co Ltd, State Key Lab New Tech Chinese Med Pharmaceut Pro, Lianyungang, Peoples R China.
C3 Northwest University Xi'an
RP Zheng, CL; Wang, YH (corresponding author), Northwest Univ, Sch Life Sci, Key Lab Resource Biol & Biotechnol Western China, Minist Educ, 229 Taibai North Rd, Xian 710069, Shaanxi, Peoples R China.; Xiao, W (corresponding author), Inst Pharmacol Toxicol, State Key Lab New Tech Chinese Med Pharmaceut Pro, Kanion Rd 58 Jiangning Ind Pk, Lianyungang 222002, Jiangsu, Peoples R China.
EM kanionlunwen@163.com; chunlizheng@126.com; yhwang@nwu.edu.cn
RI Huang, Ruifei/PAU-5931-2025; xiao, wei/KCK-6954-2024
FU Key Laboratory of Resource Biology and Biotechnology in Western China;
   National Natural Science Foundation of China [81803960, U1603285]
FX This work was supported by grants from Key Laboratory of Resource
   Biology and Biotechnology in Western China and National Natural Science
   Foundation of China (Grant No. 81803960 and U1603285).
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NR 84
TC 23
Z9 28
U1 3
U2 66
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD DEC
PY 2020
VL 79
AR 153326
DI 10.1016/j.phymed.2020.153326
PG 11
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA OG0BW
UT WOS:000581562000008
PM 32992083
DA 2026-05-27
ER

PT J
AU Mei, MX
   Cai, RH
   Yu, QH
   Tian, RK
   Zhu, W
   Song, JP
   Wu, DH
AF Mei, Manxue
   Cai, Ruhang
   Yu, Qihua
   Tian, Renkui
   Zhu, Wei
   Song, Jianping
   Wu, Dinghong
TI Salidroside alleviates UVB-induced skin damage by inhibiting
   keratinocytes pyroptosis via the AQP3/ROS/GSDMD-N signaling pathway
SO JOURNAL OF FUNCTIONAL FOODS
LA English
DT Article
DE Salidroside; UVB; AQP3; Pyroptosis; Keratinocytes; Oxidative stress
ID OXIDATIVE DAMAGE; STRESS; VITAGENES
AB Background: Salidroside (SAL) is the main component of Renus Rhodiola, Studies have shown that it has antiinflammation, reduces oxidative stress and anti-aging effect. However, its efficacy and mechanism of protecting skin barrier function have not been studied. Purpose: This study demonstrated that whether and how SAL alleviate UVB-induced skin damage and repair skin barrier. Materials and methods: UVB was used to induce photodamage in HaCaT cell line in vitro. MTT assay was used to detect the protective effect of SAL on UVB induced light damage of HaCaT cells, flow cytometry was used to detect the apoptosis and ROS level of HaCaT cells, the related kits were used to detect the relevant indicators of oxidative stress in cells, WB was used to detect protein expression in cells, and AQP3 in HaCaT cell line was overexpressed for further exploration of the way SAL plays its role. BALB/c mice with back hair removed were treated with SAL for 7 days, and the mice were irradiated with UVB every day from the third day. GPSkin was used to detect Trans Epidermal Water Loss (TEWL), hydration and barrier score of mouse skin. HE staining was used to observe the pathological changes of skin lesion, IHC was used to detect the expression of AQP3 and NLRP3, and WB was used to detect the expression of proteins related to pyroptosis. Results: SAL significantly alleviates UVB-induced photodamage by inhibiting the activation of AQP3/ROS/ GSDMD-N in damaged skin tissues and keratinocytes, both in vitro and in vivo. This leads to a reduction in skin lesions and levels of IL-18 and IL-1 & beta; in cellular supernatants, thereby relieving UVB-induced oxidative stress and downregulation of necroptosis-related proteins (P < 0.05). Conclusion: Thus, our studies demonstrate that SAL can reduce UVB-induced photo damage by down regulating the expression of AQP3 to reduce the transport of H2O2 into keratinocytes. Thus attenuate oxidative stress and NLRP3 dependent cell pyroptosis. Therefore, SAL, could serve as a potential AQP3 inhibitor to alleviate skin photo damage.
C1 [Zhu, Wei; Wu, Dinghong] Guangdong Prov Hosp Chinese Med, South 3rd Rd, Guangzhou 510006, Guangdong, Peoples R China.
   [Mei, Manxue; Cai, Ruhang; Song, Jianping] Guangzhou Univ Chinese Med, Artemisinin Res Ctr, 12 Airport Rd, Guangzhou 510405, Guangdong, Peoples R China.
   [Yu, Qihua; Tian, Renkui; Zhu, Wei] Guangzhou Univ Chinese Med, Clin Coll 2, Guangzhou 510006, Guangdong, Peoples R China.
   [Zhu, Wei] Guangdong Prov Acad Chinese Med Sci, Guangzhou 510006, Guangdong, Peoples R China.
   [Song, Jianping] Guangzhou Univ Chinese Med, Inst Sci & Technol, Guangzhou 510445, Guangdong, Peoples R China.
C3 Guangzhou University of Chinese Medicine; Guangzhou University of
   Chinese Medicine; Guangzhou University of Chinese Medicine; Guangzhou
   University of Chinese Medicine; Guangzhou University of Chinese Medicine
RP Zhu, W; Wu, DH (corresponding author), Guangdong Prov Hosp Chinese Med, South 3rd Rd, Guangzhou 510006, Guangdong, Peoples R China.; Song, JP (corresponding author), Guangzhou Univ Chinese Med, Artemisinin Res Ctr, 12 Airport Rd, Guangzhou 510405, Guangdong, Peoples R China.
EM zhuwei9201@163.com; zhuwei9201@163.com; cindywoo@gzucm.edu.cn
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NR 34
TC 11
Z9 14
U1 1
U2 63
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1756-4646
EI 2214-9414
J9 J FUNCT FOODS
JI J. Funct. Food.
PD AUG
PY 2023
VL 107
AR 105647
DI 10.1016/j.jff.2023.105647
EA JUL 2023
PG 11
WC Food Science & Technology; Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology; Nutrition & Dietetics
GA P1ZN0
UT WOS:001048694000001
OA gold
DA 2026-05-27
ER

PT J
AU Xie, RY
   Fang, XL
   Zheng, XB
   Lv, WZ
   Li, YJ
   Rage, HI
   He, QL
   Zhu, WP
   Cui, TX
AF Xie, Rui-yan
   Fang, Xue-ling
   Zheng, Xiao-bin
   Lv, Wei-ze
   Li, Yi-jie
   Rage, Hamze Ibrahim
   He, Qiao-lan
   Zhu, Wei-ping
   Cui, Tong-xia
TI Salidroside and FG-4592 ameliorate high glucose-induced glomerular
   endothelial cells injury via HIF upregulation
SO BIOMEDICINE & PHARMACOTHERAPY
LA English
DT Article
DE FG-4592; HIF-1 alpha; HIF-2 alpha; High glucose; Salidmside
ID DIABETIC-NEPHROPATHY; OXIDATIVE STRESS; HYPOXIA; OXYGENATION;
   PROGRESSION; ACTIVATION; ANEMIA
AB Increasing research indicates that hyperglycemia plays a crucial role in the progression of diabetic nephropathy (DN); however, effective treatment for preventing or slowing DN progression are seriously lacking. Although salidroside (SAL) has been demonstrated to have a positive anti-diabetic effect, the cellular mechanisms remain unclear. FG-4592, a novel prolyl hydroxylase inhibitor, was used to regulate HIF-1 alpha and HIF-2 alpha expression. The present study aimed to explore the underlying mechanisms of SAL and FG-4592 on high glucose (HG)-induced rat glomerular endothelial cells (rGECs) injury. HG-cultured rGECs were used to induce a diabetic environment. An MIT assay, RT-qPCR, Western blot, flow cytometry, and immunofluorescent staining were performed to investigate the effects of SAL on HG-induced rGECs injury. FG-4592 and SAL protected rGECs against HG-induced injury by increasing cellular viability and reducing the cell apoptosis rate. SAL and FG-4592 down-regulated PHD-2 expression and upregulated HIF-1 alpha and HIF-2 alpha expression. In conclusion, our findings suggest that SAL and FG-4592 ameliorate HG-induced rGEC injury by upregulating HIF expression, indicating that SAL and FG-4592 might be favorable for further DN-treatment.
C1 [Xie, Rui-yan; Fang, Xue-ling; Rage, Hamze Ibrahim; He, Qiao-lan; Zhu, Wei-ping; Cui, Tong-xia] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Nephrol, 52 Meihua Rd, Zhuhai 519000, Peoples R China.
   [Zheng, Xiao-bin] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Resp Med, 52 Meihua Rd, Zhuhai 519000, Peoples R China.
   [Lv, Wei-ze] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Oncol, 52 Meihua Rd, Zhuhai 519000, Peoples R China.
   [Li, Yi-jie] Sun Yat Sen Univ, Affiliated Hosp 5, Dept Gen Surg 2, 52 Meihua Rd, Zhuhai 519000, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University;
   Sun Yat Sen University
RP Zhu, WP; Cui, TX (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 5, Dept Nephrol, 52 Meihua Rd, Zhuhai 519000, Peoples R China.
EM zhuwp@mail.sysi.edu.cn; tongxia_ctx@126.com
OI Zhu, weiping/0000-0002-8856-5609
FU Natural Science Foundation of Guangdong Province Program
   [2016A030310193]
FX This study was supported in part by the grants from the Natural Science
   Foundation of Guangdong Province Program (NO. 2016A030310193).
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NR 37
TC 35
Z9 40
U1 2
U2 19
PU ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
PI ISSY-LES-MOULINEAUX
PA 65 RUE CAMILLE DESMOULINS, CS50083, 92442 ISSY-LES-MOULINEAUX, FRANCE
SN 0753-3322
EI 1950-6007
J9 BIOMED PHARMACOTHER
JI Biomed. Pharmacother.
PD OCT
PY 2019
VL 118
AR 109175
DI 10.1016/j.biopha.2019.109175
PG 8
WC Medicine, Research & Experimental; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine; Pharmacology & Pharmacy
GA IY4WZ
UT WOS:000486395000066
PM 31351423
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhan, XQ
   Zhang, Y
   Lin, WD
   Fu, SY
   Huang, J
AF Zhan, Xueqiang
   Zhang, Yu
   Lin, Wendong
   Fu, Shuying
   Huang, Jie
TI Salidroside Alleviates Renal Ischemia-reperfusion Injury by Inhibiting
   Macrophage Pyroptosis Through HIF Signaling
SO INFLAMMATION
LA English
DT Article
DE RIRI; Sa; Macrophage; Pyroptosis; HIF
ID KIDNEY; PATHWAY; EXPRESSION
AB Renal ischemia-reperfusion injury (RIRI) is a critical pathological process characterized by hypoxia-driven inflammation and cell death. This study investigates the renoprotective effects of salidroside (Sa), a bioactive compound from Rhodiola rosea, in a murine RIRI model, focusing on its regulation of the HIF-1 alpha-pyroptosis axis in macrophages. Through integrative approaches combining in vivo experiments, multiomics analysis, and functional assays, we demonstrated that Sa administration significantly attenuated renal dysfunction and tubular necrosis in RIRI mice. Mechanistically, Sa suppressed hypoxia-reoxygenation-induced HIF-1 alpha stabilization in macrophages by quenching intracellular ROS, thereby disrupting the ROS-HIF-1 alpha positive feedback loop. This inhibition led to reduced activation of the NLRP3 inflammasome, cleavage of gasdermin D (GSDMD), and secretion of pro-inflammatory cytokines (IL-1 beta/IL-18), ultimately mitigating macrophage pyroptosis. Single-cell RNA sequencing and network pharmacology further corroborated HIF-1 signaling as a central hub for Sa's action, with downregulation of pyroptosis-related genes in renal macrophages. Our findings establish Sa as a multi-target agent that alleviates RIRI by targeting the HIF-1 alpha-driven pyroptotic cascade, offering a promising therapeutic strategy for ischemic kidney injury. Further studies are warranted to validate its clinical potential and molecular specificity.
C1 [Zhan, Xueqiang; Zhang, Yu; Lin, Wendong; Fu, Shuying; Huang, Jie] Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Anesthesiol, 79 Qingchun Rd, Hangzhou, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Huang, J (corresponding author), Zhejiang Univ, Sch Med, Affiliated Hosp 1, Dept Anesthesiol, 79 Qingchun Rd, Hangzhou, Zhejiang, Peoples R China.
EM huangjie0808@zcmu.edu.cn
FU Hospital fund of the First Affiliated Hospital of Zhejiang University
   School of Medicine
FX We appreciate the language polishing services provided by the Home of
   Researchers.
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NR 24
TC 6
Z9 6
U1 4
U2 9
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0360-3997
EI 1573-2576
J9 INFLAMMATION
JI Inflammation
PD DEC
PY 2025
VL 48
IS 6
BP 4318
EP 4329
DI 10.1007/s10753-025-02328-y
EA JUL 2025
PG 12
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA AL8OU
UT WOS:001520731300001
PM 40591075
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhang, XM
   Li, JY
   Zhang, L
   Wu, XL
   Wang, YJ
   Zhang, LL
   Zhou, Y
   Han, LF
   Wang, LM
   Liu, ER
AF Zhang, Xuemei
   Li, Jinyan
   Zhang, Lin
   Wu, Xiaolin
   Wang, Yijun
   Zhang, Lele
   Zhou, Ying
   Han, Lifeng
   Wang, Liming
   Liu, Erwei
TI Integration WGCNA with LC-MS data for evaluating the processing status
   and transformation rules of Ligustri Lucidi Fructus: A novel strategy
   for evaluating the processing technology of traditional Chinese
   medicines
SO TALANTA
LA English
DT Article
DE Ligustri Lucidi Fructus; WGCNA; Data-independent acquisition; LC-MS
   data; Processing status; Transformation rules
ID MASS-DEFECT; MS/MS
AB Ligustri Lucidi Fructus (LLF) is a traditional Chinese medicine (TCM) to treat hepatopathy and osteopathy. Wineprocessed LLF (WLLF) was much more widely used than raw LLF (RLLF) in clinical practice, however, there is no consensus on processing time. To investigate the processing status of WLLF and transformation rules during processing, a UHPLC-Q-Orbitrap-MS method combined with data-independent acquisition (DIA) mode was firstly established and 227 compounds were identified or tentatively identified. Subsequently, a novel strategy using integration weighted gene co-expression network analysis (WGCNA) with LC-MS data was proposed. A total of 73 differential metabolites were screened out between RLLF and WLLF (wine steaming for 18 h). Meanwhile, the concentration of 11 differential compounds for WLLF was quantified. Finally, correlations between compounds were analyzed by WGCNA and the top five compounds negatively correlated with salidroside were validated, revealing that G13, specnuezhenide, oleuropein, acteoside, and neonuzhenide could be transformed into salidroside and its analogues during processing, respectively. The results indicated that our proposed strategy could be effectively employed to evaluate the processing status of TCMs.
C1 [Zhang, Xuemei; Li, Jinyan; Zhang, Lin; Wu, Xiaolin; Wang, Yijun; Zhang, Lele; Zhou, Ying; Han, Lifeng; Wang, Liming; Liu, Erwei] Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin Key Lab TCM Chem & Anal, Tianjin 301617, Peoples R China.
   [Han, Lifeng; Wang, Liming; Liu, Erwei] Haihe Lab Modern Chinese Med, Tianjin 301617, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine
RP Wang, LM; Liu, ER (corresponding author), Tianjin Univ Tradit Chinese Med, State Key Lab Component Based Chinese Med, Tianjin Key Lab TCM Chem & Anal, Tianjin 301617, Peoples R China.
EM wangliming_111@163.com; Liuwei628@hotmail.com
RI Zhang, Lele/GQQ-4020-2022; Wu, Xiaolin/GPX-5124-2022; Wang,
   Liming/GQA-9769-2022
OI Wang, Liming/0000-0002-9329-4559
FU Traditional Chinese Medicine Processing Technology Inheritance Base
   (Tianjin) of the State Administration of Traditional Chinese Medicine
   [PZJD2022]; Science and Technology Program of Tianjin in China
   [23ZYJDSS00030]; Science and Technology Project of Haihe Laboratory of
   Modern Chinese Medicine [22HHZYSS00007]
FX This work was supported by Traditional Chinese Medicine Processing
   Technology Inheritance Base (Tianjin) of the State Administration of
   Traditional Chinese Medicine (PZJD2022), the Science and Technology
   Program of Tianjin in China (No. 23ZYJDSS00030), and Science and
   Technology Project of Haihe Laboratory of Modern Chinese Medicine
   (22HHZYSS00007).
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   Zhang X, 2024, TALANTA, V267, DOI 10.1016/j.talanta.2023.125136
   Zong JK, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms241814398
NR 50
TC 4
Z9 4
U1 7
U2 38
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0039-9140
EI 1873-3573
J9 TALANTA
JI Talanta
PD JAN 1
PY 2025
VL 282
AR 127029
DI 10.1016/j.talanta.2024.127029
EA OCT 2024
PG 12
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA J5W9W
UT WOS:001337779000001
PM 39418977
DA 2026-05-27
ER

PT J
AU Zhao, GQ
   Zhang, T
   Li, JN
   Li, LY
   Chen, P
   Zhang, CL
   Li, K
   Cui, CC
AF Zhao, Guoqing
   Zhang, Te
   Li, Jiannan
   Li, Longyun
   Chen, Peng
   Zhang, Chunlu
   Li, Kai
   Cui, Cancan
TI Parkin-mediated mitophagy is a potential treatment for
   oxaliplatin-induced peripheral neuropathy
SO AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
LA English
DT Article
DE mitophagy; oxaliplatin; peripheral nerve pain; Parkin; salidroside
ID MITOCHONDRIAL DYSFUNCTION; PINK1/PARKIN-MEDIATED MITOPHAGY; TACTILE
   ALLODYNIA; UBIQUITIN CHAIN; PINK1; CHEMOTHERAPY; MECHANISMS; AUTOPHAGY;
   CELLS; PAIN
AB Oxaliplatin-induced peripheral nerve pain (OIPNP) is a common chemotherapy-related complication, but the mechanism is complex. Mitochondria are vital for cellular homeostasis and regulating oxidative stress. Parkin-mediated mitophagy is a cellular process that removes damaged mitochondria, exhibiting a protective effect in various diseases; however, its role in OIPNP remains unclear. In this study, we found that Parkin-mediated mitophagy was decreased, and reactive oxygen species (ROS) was upregulated in OIPNP rat dorsal root ganglion (DRG) in vivo and in PC12 cells stimulated with oxaliplatin (OXA) in vitro. Overexpression of Parkin indicated that OXA might cause mitochondrial and cell damage by inhibiting mitophagy. We also showed that salidroside (SAL) upregulated Parkin-mediated mitophagy to eliminate damaged mitochondria and promote PC12 cell survival. Knockdown of Parkin indicated that mitophagy is crucial for apoptosis and mitochondrial homeostasis in PC12 cells. In vivo study also demonstrated that SAL enhances Parkin-mediated mitophagy in the DRG and alleviates peripheral nerve injury and pain. These results suggest that Parkin-mediated mitophagy is involved in the pathogenesis of OIPNP and may be a potential therapeutic target for OIPNP.
C1 [Zhao, Guoqing; Zhang, Te; Li, Longyun; Chen, Peng; Zhang, Chunlu; Li, Kai] Jilin Univ, China Japan Union Hosp, Anesthesiol Dept, Changchun, Peoples R China.
   [Li, Jiannan] Jilin Univ, China Japan Union Hosp, Dept Plast & Reconstruct Microsurg, Changchun, Peoples R China.
   [Cui, Cancan] Jilin Univ, China Japan Union Hosp, Radiol Dept, Changchun, Peoples R China.
C3 Jilin University; Jilin University; Jilin University
RP Zhao, GQ (corresponding author), Jilin Univ, China Japan Union Hosp, Anesthesiol Dept, Changchun, Peoples R China.
EM guoqing@jlu.edu.cn
RI li, jn/ABH-3120-2021; Cui, Cancan/HNC-4267-2023
FU Jilin Province Science and Technology Development Plan Project; Natural
   Science Foundation of Jilin Province [3D5206062430, 3D5230920430]
FX This research was funded by Jilin Province Science and Technology
   Development Plan Project and Natural Science Foundation of Jilin
   Province, Grant Numbers are 3D5206062430 and 3D5230920430, respectively
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Z9 15
U1 0
U2 22
PU AMER PHYSIOLOGICAL SOC
PI Rockville
PA 6120 Executive Blvd, Suite 600, Rockville, MD, UNITED STATES
SN 0363-6143
EI 1522-1563
J9 AM J PHYSIOL-CELL PH
JI Am. J. Physiol.-Cell Physiol.
PD JAN 11
PY 2024
VL 326
IS 1
BP C214
EP C228
DI 10.1152/ajpcell.00276.2023
PG 15
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA FD5C7
UT WOS:001143825600001
PM 38073486
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Chen, QF
   Yang, LJ
   Zhang, GL
   Wang, F
AF Chen, Qianfeng
   Yang, Lijuan
   Zhang, Guolin
   Wang, Fei
TI Bioactivity-guided Isolation of Antiosteoporotic Compounds from
   Ligustrum lucidum
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE Ligustrum lucidum; alkaline phosphatase; osteoblast; estrogen receptor;
   antioxidant
ID OVARIECTOMY-INDUCED OSTEOPOROSIS; ETHANOL EXTRACT; OLEANOLIC ACID;
   ESTROGEN; PATHOGENESIS; ENHANCEMENT; FRUITS; AIT
AB The fruits of Ligustrum lucidum (FLL) has long been used for the treatment of osteoporosis in China, but the antiosteoporotic compounds in FLL are still poorly understood. In this study, the alkaline phosphatase (ALP) activity-guided isolation of osteogenic components from FLL was carried out by using osteoblast-like UMR-106 cells. Eight compounds, namely tyrosol (1), tyrosyl acetate (2), hydroxytyrosol (3), salidroside (4), oleoside dimethyl ester (5), oleoside-7-ethyl-11-methyl ester (6), nuzhenide (7), and G13 (8), were isolated and identified. Further study showed that compounds 3, 4, 7, and 8 increased ALP activity in UMR-106 cells. Compounds 5, 6, and 7 promoted the proliferation of UMR-106 cells. The aqueous extract of FLL-activated ER/-mediated gene transcription, whereas the isolated compounds were inactive. All eight isolated compounds also exhibited antioxidative activity, with compounds 1, 2, and 3 being the most potent. These results indicate that the antiosteoporotic effect of FLL is derived from different compounds together with different mechanisms such as ER-dependent or independent pathways and antioxidative effects. Salidroside (4) and nuzhenide (7) warrant further investigation as new pharmaceutical tools for the prevention and treatment of osteoporosis. Copyright (c) 2012 John Wiley & Sons, Ltd.
C1 [Chen, Qianfeng; Yang, Lijuan; Zhang, Guolin; Wang, Fei] Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China.
C3 Chinese Academy of Sciences; Chengdu Institute of Biology, CAS
RP Zhang, GL (corresponding author), Chinese Acad Sci, Chengdu Inst Biol, Chengdu 610041, Peoples R China.
EM zhanggl@cib.ac.cn; wangfei@cib.ac.cn
RI ; Wang, Fei/ABE-3386-2021
OI Wang, Fei/0000-0002-2513-502X; 
FU West Light Foundation; Chinese Academy of Sciences; National Natural
   Science Foundation of China [20932007, 30900769]; National New Drug
   Innovation Major Project of China [2011ZX09307-002-02]
FX <BOLD>T</BOLD>his work was partially supported by the West Light
   Foundation, Chinese Academy of Sciences, the National Natural Science
   Foundation of China (No. 20932007, 30900769), and the National New Drug
   Innovation Major Project of China (2011ZX09307-002-02).
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NR 33
TC 50
Z9 66
U1 2
U2 51
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JUL
PY 2013
VL 27
IS 7
BP 973
EP 979
DI 10.1002/ptr.4820
PG 7
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 176UR
UT WOS:000321331800003
PM 22893624
DA 2026-05-27
ER

PT J
AU Zhang, X
   Du, QM
   Yang, Y
   Wang, JN
   Liu, YX
   Zhao, Z
   Zhu, YB
   Liu, C
AF Zhang, Xu
   Du, Qianming
   Yang, Yan
   Wang, Jianing
   Liu, Yunxin
   Zhao, Zheng
   Zhu, Yubing
   Liu, Chao
TI Salidroside alleviates ischemic brain injury in mice with ischemic
   stroke through regulating BDNK mediated PI3K/Akt pathway
SO BIOCHEMICAL PHARMACOLOGY
LA English
DT Article
DE Sal; Brain ischemia/reperfusion; BDNK; Apoptosis
ID APOPTOSIS
AB There is evidence suggesting that inhibition of apoptosis plays a critical role in preventing neurons from damage and even death, after brain ischemia/reperfusion, which shows therapeutic potential for clinical treatment of brain injury. In this study, We preformed MCAO model in C57BL/6J wild-type (BDNK +/+) and BDNK knockout (BDNF -/-) mice respectively, and investigated the neuroprotective effect of Salidroside (Sal) and its underlying mechanisms. The results showed that Sal reversed brain infarct size, reduced cerebral edema, decreased the neurological deficit score and diminished TUNEL positive cells significantly. However, BDNK deficiency inhibited the neuroprotective effect of Sal. In addition, Sal increased cell viability, ameliorated neuron cell injury by decreasing LDH activity, and inhibited cell apoptotic rate. Sal suppressed apoptotic signaling via DNA binding-dependent and-independent mechanisms. Furthermore, the neuroprotective effect of Sal on BDNK was mediated by PI3K/Akt pathway, which was proved by the use of PI3K knockout (PI3K -/-) mice and siRNA-PI3K. In summary, these data strongly suggested that Sal could be used as an effective neuroprotective agent to protect against ischemic stroke after cerebral I/R injury through regulating BDNK-mediated PI3K/Akt apoptotic pathway in DNA-binding-dependent and -independent manners.
C1 [Zhang, Xu] Chengdu Med Coll, Chengdu Peoples Hosp 1, Affiliated Tradit Chinese & Western Med Hosp, Dept Pharm, 18 Wanxiang North Rd, Chengdu 610031, Sichuan, Peoples R China.
   [Du, Qianming] Nanjing Med Univ, Nanjing Hosp 1, Gen Clin Res Ctr, Nanjing 210006, Jiangsu, Peoples R China.
   [Du, Qianming; Liu, Chao] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Dept Clin Pharm, Nanjing 210009, Jiangsu, Peoples R China.
   [Yang, Yan] Southwest Jiaotong Univ, Peoples Hosp Chengdu 3, Dept Pharm, 82 Qing Long St, Chengdu 610031, Sichuan, Peoples R China.
   [Yang, Yan] Southwest Jiaotong Univ, Affiliated Hosp, 82 Qing Long St, Chengdu 610031, Sichuan, Peoples R China.
   [Wang, Jianing] China Pharmaceut Univ, Jiangsu Ctr Drug Screening, Neurobiol Lab, Nanjing 210009, Jiangsu, Peoples R China.
   [Liu, Yunxin; Zhao, Zheng; Zhu, Yubing; Liu, Chao] Nanjing Med Univ, Nanjing Hosp 1, Dept Pharm, Nanjing 210006, Jiangsu, Peoples R China.
C3 Chengdu Medical College; Nanjing Medical University; China
   Pharmaceutical University; Southwest Jiaotong University; Southwest
   Jiaotong University; China Pharmaceutical University; Nanjing Medical
   University
RP Zhu, YB; Liu, C (corresponding author), Nanjing Med Univ, Nanjing Hosp 1, Dept Pharm, Nanjing 210006, Jiangsu, Peoples R China.
EM zyb86052002@163.com; 13311010047@stu.cpu.edu.cn
RI ; wang, jianing/LCE-6869-2024
OI Du, Qianming/0000-0003-3510-1373; , Qianming Du/0000-0002-1092-2899; 
FU Natural Science Foundation of China [81702833, 81703781, 81803513];
   Natural Science Foundation of Jiangsu Province [BK20170137, BK20170140];
   Sichuan Science and Technology Program [2018JY0204]; Natural Science
   Foundation of Chengdu Medical College [CYZ17-13]; Nanjing Medical
   University [2016NJMUZD041, 2016NJMUZD043]
FX This work was supported by the Natural Science Foundation of China (Nos.
   81702833, 81703781, and 81803513), the Natural Science Foundation of
   Jiangsu Province (Nos. BK20170137 and BK20170140), Sichuan Science and
   Technology Program (No. 2018JY0204) and Natural Science Foundation of
   Chengdu Medical College (No. CYZ17-13) and the Science and Technology
   Development Fund Project of Nanjing Medical University (Nos.
   2016NJMUZD041 and 2016NJMUZD043). We thank Nanjing BIORN Life Science
   for technical support.
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NR 36
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Z9 67
U1 0
U2 22
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0006-2952
EI 1873-2968
J9 BIOCHEM PHARMACOL
JI Biochem. Pharmacol.
PD OCT
PY 2018
VL 156
BP 99
EP 108
DI 10.1016/j.bcp.2018.08.015
PG 10
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA GY3XX
UT WOS:000448491500011
PM 30114387
DA 2026-05-27
ER

PT J
AU Sutula, M
   Gubaidullin, N
   Rakhimzhanova, A
   Manabayeva, S
AF Sutula, Maxim
   Gubaidullin, Nurtai
   Rakhimzhanova, Aizhan
   Manabayeva, Shuga
TI Stress-Induced Secondary Metabolite Profiling in Cistanche
   deserticola Callus Cultures: Insights from GC-MS and HPLC-MS
   Analysis
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE <italic>C. deserticola</italic>; callus culture; secondary metabolites;
   GC-MS; qTOF-UHPLC-MS; PhGs
ID PHENYLPROPANOID GLYCOSIDES; ANTIOXIDANT ACTIVITY; PHENOLIC-COMPOUNDS;
   PLANTS; EXTRACTS
AB Throughout human history, wild plant resources have played an invaluable role, serving as critical sources of food, medicine, and industrial materials. This study examined the callus cultures of Cistanche deserticola Y.C. Ma, a medicinal desert plant, by subjecting them to abiotic stress under controlled in vitro conditions. The secondary metabolite profiles were then analyzed using GC-MS and qTOF-UHPLC-MS. The GC-MS analysis revealed several bioactive compounds of pharmaceutical interest, such as gamma-sitosterol and homovanillyl alcohol. PhGs, including echinacoside and salidroside, were quantified for the first time across 16 callus samples exposed to various stress treatments. The application of 0.1% Na2CO3 for 50 days resulted in the highest accumulation of echinacoside (13,378.9 mu g/mL), and heavy metal stress notably increased salidroside levels to 27.0 mu g/mL. There was a clear correlation between callus pigmentation and metabolic activity: orange and white calli produced significantly more PhGs than dark calli. These results suggest that C. deserticola callus cultures could be a sustainable, controllable platform for producing high-value secondary metabolites. This reinforces the importance of wild plant resources in modern science and industry.
C1 [Sutula, Maxim; Gubaidullin, Nurtai; Rakhimzhanova, Aizhan; Manabayeva, Shuga] Natl Ctr Biotechnol, Plant Genet Engn Lab, Astana 010000, Kazakhstan.
   [Manabayeva, Shuga] LN Gumilyov Eurasian Natl Univ, Fac Nat Sci, Astana 010000, Kazakhstan.
C3 JSC National Holding QazBioPharm; National Center for Biotechnology
   (NCB); L.N. Gumilyov Eurasian National University
RP Manabayeva, S (corresponding author), Natl Ctr Biotechnol, Plant Genet Engn Lab, Astana 010000, Kazakhstan.; Manabayeva, S (corresponding author), LN Gumilyov Eurasian Natl Univ, Fac Nat Sci, Astana 010000, Kazakhstan.
EM m.sutula@biocenter.kz; nur-tai.kz@mail.ru; r.aizhann@mail.ru;
   manabayeva@biocenter.kz
RI /ABI-1883-2020; /A-2529-2015; Gubaidullin, Nurtai/HJA-2050-2022; Sutula,
   Maxim/AAX-2587-2020
OI Gubaidullin, Nurtai/0000-0002-8185-714X; Sutula,
   Maxim/0000-0002-3153-6356
FU Science Committee of the Ministry of Science and Higher Education of the
   Republic of Kazakhstan;  [BR21882180]
FX This research was carried out as part of Program BR21882180, "Strategy
   Creation for Conserving and Developing Medicinal and Veterinary Plant
   Resources in Kazakhstan amid Climate Change", which is supported by the
   Science Committee of the Ministry of Science and Higher Education of the
   Republic of Kazakhstan.
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NR 86
TC 1
Z9 1
U1 4
U2 6
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN 25
PY 2025
VL 26
IS 13
AR 6091
DI 10.3390/ijms26136091
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 4TQ7B
UT WOS:001526400900001
PM 40649869
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Hu, ML
   Zhang, DR
   Xu, HY
   Zhang, Y
   Shi, HJ
   Huang, XL
   Wang, XH
   Wu, Y
   Qi, ZL
AF Hu, Manli
   Zhang, Dingran
   Xu, Hongyang
   Zhang, Yan
   Shi, Hongjie
   Huang, Xiaoli
   Wang, Xinhui
   Wu, Yan
   Qi, Zhili
TI Salidroside Activates the AMP-Activated Protein Kinase Pathway to
   Suppress Nonalcoholic Steatohepatitis in Mice
SO HEPATOLOGY
LA English
DT Article
ID FATTY LIVER-DISEASE; RHODIOLA-ROSEA EXTRACTS; INSULIN-RESISTANCE;
   APOPTOSIS; INJURY; REGULATOR; GLUCOSE; GROWTH
AB Background and Aims NASH is becoming a leading cause of liver cirrhosis and HCC. Salidroside (p-hydroxyphenethyl-beta-D-glucoside; SAL) has various biological and pharmacological activities, including anti-inflammatory, -oxidant, and -cancer activities. However, the therapeutic effect and underlying molecular mechanism of SAL in NASH remain to be further clarified. Methods and Results In this study, we found that SAL alleviated lipid accumulation and inflammatory response in primary hepatocytes after palmitic acid/oleic acid (PO) stimulation. In addition, SAL effectively prevented high-fat/high-cholesterol (HFHC)-diet-induced NASH progression by regulating glucose metabolism dysregulation, insulin resistance, lipid accumulation, inflammation, and fibrosis. Mechanistically, integrated RNA-sequencing and bioinformatic analysis showed that SAL promoted AMPK-signaling pathway activation in vitro and in vivo, and this finding was further verified by determining the phosphorylation levels of AMPK. Furthermore, the protective effects of SAL on lipid accumulation and inflammation in hepatocytes and livers induced by PO or HFHC stimulation were blocked by AMPK interruption. Conclusions Our studies demonstrate that SAL protects against metabolic-stress-induced NASH progression through activation of AMPK signaling, indicating that SAL could be a potential drug component for NASH therapy.
C1 [Hu, Manli; Zhang, Dingran; Xu, Hongyang; Wang, Xinhui; Wu, Yan; Qi, Zhili] Huazhong Agr Univ, Coll Anim Sci & Technol, Dept Anim Nutr & Feed Sci, Wuhan, Hubei, Peoples R China.
   [Hu, Manli] Zhongnan Hosp Wuhan Univ, Med Sci Res Ctr, Wuhan, Hubei, Peoples R China.
   [Zhang, Yan; Shi, Hongjie; Huang, Xiaoli] Renmin Hosp Wuhan Univ, Dept Cardiol, Wuhan, Hubei, Peoples R China.
C3 Huazhong Agricultural University; Wuhan University; Wuhan University
RP Qi, ZL (corresponding author), Huazhong Agr Univ, Coll Anim Sci & Technol, 1 Shizishan St, Wuhan 430070, Hubei, Peoples R China.
EM zhiliqi@mail.hzau.edu.cn
RI ; Xu, Hongyang/GYD-7660-2022; hongjie, Shi/LKK-7798-2024
OI Hu, Man-Li/0000-0001-8318-0454; 
FU National Key Research and Development Program of China [2018YFD0501605,
   2016YFD0500507]; Fundamental Research Funds for the Central Universities
   [2662018PY079]
FX This study was supported by the National Key Research and Development
   Program of China (2018YFD0501605, 2016YFD0500507) and the Fundamental
   Research Funds for the Central Universities (2662018PY079).
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NR 39
TC 81
Z9 94
U1 6
U2 134
PU LIPPINCOTT WILLIAMS & WILKINS
PI PHILADELPHIA
PA TWO COMMERCE SQ, 2001 MARKET ST, PHILADELPHIA, PA 19103 USA
SN 0270-9139
EI 1527-3350
J9 HEPATOLOGY
JI Hepatology
PD DEC
PY 2021
VL 74
IS 6
BP 3056
EP 3073
DI 10.1002/hep.32066
EA OCT 2021
PG 18
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA XK3HF
UT WOS:000709406700001
PM 34292604
DA 2026-05-27
ER

PT J
AU Aiello, N
   Bontempo, R
   Vender, C
   Innocenti, G
   Dall'Acqua, S
AF Aiello, N.
   Bontempo, R.
   Vender, C.
   Innocenti, G.
   Dall'Acqua, S.
TI Morphological and qualitative characteristics of Rhodiola rosea
   L. wild populations of Trentino, Italy
SO ZEITSCHRIFT FUR ARZNEI- & GEWURZPFLANZEN
LA English
DT Article
DE morphological characteristics; Rhodiola rosea; rosavin; rosin;
   salidroside; wild collection
ID BIOLOGICALLY-ACTIVE COMPOUNDS; ROOTS
AB Rhodiola rosea L. is a medicinal plant with many traditional and medicinal uses. The underground part is valued for its ability to enhance human resistance to stress or fatigue. During the last years, the Unita di ricerca per il Monitoraggio e la Pianificazione Forestale of Villazzano (Trento) has been gathering data and seeds of different alpine medicinal and aromatic plants with the aim of having a wider knowledge about these species in situ and carrying out an ex situ cultivation to assess their diversity and to verify if some accessions could give interesting results for future selection work.
   This paper reports the morphological and phytochemical data of the six wild roseroot populations collected in situ in 2010 in Trentino (Italy). Analytical determinations were obtained by HPLC-DAD. The measured data were as follows: length of shoots 23-44 cm, number of shoots 17-38, thickness of shoots 3.8-5 mm, leaf length 20.7-44.5 mm, leaf width 5.3-6.5 mm, salidroside content 0.27-1.16%, rosavin content 0.25-0.56%, rosin content 0.015-0.049%. In particular, the plants collected in Malga Bondolo, followed by Rifugio Larcher, had the highest values in all the recorded traits.
C1 [Aiello, N.; Bontempo, R.; Vender, C.] Consiglio Ric & Sperimentaz Agr, Unita Ric Monitoraggio & Pianificaz Forestale, I-38123 Trento, Italy.
   [Innocenti, G.; Dall'Acqua, S.] Univ Padua, Dept Pharmaceut & Pharmacol Sci, I-35131 Padua, Italy.
C3 Consiglio per la Ricerca in Agricoltura e L'analisi Dell'economia
   Agraria (CREA); University of Padua
RP Aiello, N (corresponding author), Consiglio Ric & Sperimentaz Agr, Unita Ric Monitoraggio & Pianificaz Forestale, Piazza Nicolini 6, I-38123 Trento, Italy.
EM nicola.aiello@entecra.it
RI ; Bontempo, Rodolfo/L-7624-2014; Dall'Acqua, Stefano/C-1353-2013
OI Aiello, Nicola/0000-0003-1147-8221; 
FU Ministry of Agricultural, Food and Forestry Policies
FX Authors thank Dr. F. Prosser and F. Zara of the Museo Civico di Rovereto
   (Trento) for the advice concerning the roseroot locations. This work is
   part of the project "FAO-RGV" financed by the Ministry of Agricultural,
   Food and Forestry Policies.
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NR 13
TC 3
Z9 3
U1 1
U2 23
PU AGRIMEDIA GMBH
PI CLENZE
PA LUCHOWER STR 13A, CLENZE, 29459, GERMANY
SN 1431-9292
J9 Z ARZNEI- GEWURZPFLA
JI Z. Arznei- Gewurzpflanzen
PD MAR
PY 2013
VL 18
IS 1
BP 41
EP 45
PG 5
WC Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences
GA 106QQ
UT WOS:000316160200006
DA 2026-05-27
ER

PT J
AU Yang, YH
   Wu, YN
   Zhuang, YB
   Liu, T
AF Yang, Yihan
   Wu, Yanan
   Zhuang, Yibin
   Liu, Tao
TI Discovery of Glycosyltransferases Involved in the Biosynthesis of
   Ligupurpuroside B
SO ORGANIC LETTERS
LA English
DT Article
ID PHENYLETHANOID GLYCOSIDES; LIGNAN; PLANTS
AB In this study, we report the characterization of three glycosyltransferases involved in the biosynthesis of ligupurpuroside B, a complex acylated phenolic glycoside in Ligustrum robustum. UGT85AF8 catalyzed the formation of salidroside from tyrosol. UGT79G7, an osmanthuside A 1,3-rhamnosyltransferase, and UGT79A19, an osmanthuside B 1,4-rhamnosyltransferase, sequentially converted osmanthuside A into ligupurpuroside B. Orthologs of UGT79G7 were also discovered from other plants producing verbascoside. These rhamnosyltransferases expand the toolbox for the biosynthesis of natural products with various sugar chains.
C1 [Yang, Yihan; Wu, Yanan; Zhuang, Yibin; Liu, Tao] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China.
   [Yang, Yihan] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
   [Wu, Yanan] Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin 300457, Peoples R China.
C3 Chinese Academy of Sciences; Tianjin Institute of Industrial
   Biotechnology, CAS; Chinese Academy of Sciences; University of Chinese
   Academy of Sciences, CAS; Tianjin University of Science & Technology
RP Liu, T (corresponding author), Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Key Lab Syst Microbial Biotechnol, Tianjin 300308, Peoples R China.
EM liu_t@tib.cas.cn
RI Yang, Yihan/ITR-9611-2023; Wu, Yanan/GZM-9484-2022
OI Yang, Yihan/0000-0002-7737-6423; zhuang, yibin/0000-0001-6369-022X; 
FU National Key Research and Development Program [2019YFA0905700]; National
   Natural Science Foundation of China [31970065, 31770104, U1902214];
   Tianjin Synthetic Biotechnology Innovation Capacity Improvement Project
   [TSBICIP-KJGG002]; Yunnan Key Research and Development Program
   [2019ZF011-2]
FX This work was supported by the National Key Research and Development
   Program (2019YFA0905700), the National Natural Science Foundation of
   China (31970065, 31770104, and U1902214), the Tianjin Synthetic
   Biotechnology Innovation Capacity Improvement Project (TSBICIP-KJGG002),
   and the Yunnan Key Research and Development Program (2019ZF011-2).
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NR 17
TC 17
Z9 24
U1 5
U2 90
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 1523-7060
EI 1523-7052
J9 ORG LETT
JI Org. Lett.
PD OCT 15
PY 2021
VL 23
IS 20
BP 7851
EP 7854
DI 10.1021/acs.orglett.1c02873
EA OCT 2021
PG 4
WC Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA WK4JN
UT WOS:000709693500031
PM 34609151
DA 2026-05-27
ER

PT J
AU Zhou, LY
   Jia, J
   Li, JP
   Yao, Z
   Fu, Z
   Wang, S
AF Zhou, Lingyi
   Jia, Jing
   Li, Jinping
   Yao, Zhi
   Fu, Zheng
   Wang, Shuai
TI Rhodiola sacra Protects Against Hippocampal Neuronal Apoptosis in
   Chronic Cerebral Ischemia via SIRT1-Driven Mitochondrial
   Biogenesis
SO CURRENT NEUROPHARMACOLOGY
LA English
DT Article; Early Access
DE Chronic cerebral ischemia; <italic>Rhodiola sacra</italic>; SIRT1;
   mitochondrial biogenesis; apoptosis; SIRT1 expression
ID INJURY; PATHWAY; STROKE; RELEASE
AB Introduction Chronic cerebral ischemia (CCI) induces hippocampal neuronal injury, with mitochondrial dysfunction emerging as a pivotal pathological driver of ischemic brain damage. Enhancing mitochondrial biogenesis (MB) represents a promising reparative strategy to restore neuronal homeostasis. Rhodiola sacra (RS), a traditional Tibetan herb, exhibits neuroprotective potential against ischemic injury; however, its underlying mechanisms, particularly its association with MB, remain unclear. This study aims to investigate the protective effects of RS on neuronal apoptosis and mitochondrial dysfunction in CCI rats and oxygen-glucose deprivation (OGD)-exposed cells, with a focus on elucidating the role of SIRT1 in mediating these effects.Methods The CCI rat model was established through bilateral common carotid artery occlusion. Spatial learning and memory abilities were evaluated using the Morris water maze. Hippocampal neuronal apoptosis was assessed via TUNEL staining, and mitochondrial damage was examined using transmission electron microscopy. Flow cytometry was employed to detect cell apoptosis, mitochondrial membrane potential (MMP), and reactive oxygen species (ROS) levels. Immunofluorescence staining was used to visualize the mitochondrial permeability transition pore (mPTP). Intracellular ATP levels were measured using a luminol-based chemiluminescence assay, and mitochondrial DNA (mtDNA) content was quantified by qPCR. Additionally, small interfering RNA (siRNA) was utilized to verify the critical role of SIRT1 in mediating the protective effects.Results RS significantly improved spatial learning and memory, attenuated hippocampal neuronal apoptosis, and increased mitochondrial content in CCI rats. In SH-SY5Y cells exposed to OGD, salidroside, a key active component of RS, reduced apoptosis and restored mitochondrial function, as evidenced by elevated MMP, ATP, and mtDNA levels, along with suppressed ROS and mPTP activity. Mechanistically, salidroside upregulated SIRT1 expression, which correlated with enhanced MB markers. Notably, inhibition of SIRT1 abolished the anti-apoptotic effects and MB activation induced by salidroside.Discussion These findings highlight RS as a promising therapeutic agent for ischemic brain injury, targeting SIRT1 to restore MB.Conclusion RS mitigates neuronal apoptosis and mitochondrial dysfunction in CCI through SIRT1-dependent MB activation.
C1 [Zhou, Lingyi] Tianjin Med Univ, Gen Hosp, Dept Blood Transfus, Tianjin 300052, Peoples R China.
   [Zhou, Lingyi; Yao, Zhi] Tianjin Med Univ, Prov & Minist Cosponsored Collaborat Innovat Ctr M, Tianjin Inst Immunol,Minist Educ,Dept Immunol, Sch Basic Med Sci,Key Lab Immune Microenvironm & D, Tianjin 300070, Peoples R China.
   [Jia, Jing; Li, Jinping; Fu, Zheng] Tianjin Kangzhe Pharmaceut Technol Dev Co Ltd, Tianjin 300042, Peoples R China.
   [Wang, Shuai] Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan 250117, Shandong, Peoples R China.
C3 Tianjin Medical University; Tianjin Medical University; Shandong First
   Medical University & Shandong Academy of Medical Sciences
RP Yao, Z (corresponding author), Tianjin Med Univ, Prov & Minist Cosponsored Collaborat Innovat Ctr M, Tianjin Inst Immunol,Minist Educ,Dept Immunol, Sch Basic Med Sci,Key Lab Immune Microenvironm & D, Tianjin 300070, Peoples R China.; Fu, Z (corresponding author), Tianjin Kangzhe Pharmaceut Technol Dev Co Ltd, Tianjin 300042, Peoples R China.; Wang, S (corresponding author), Shandong First Med Univ & Shandong Acad Med Sci, Shandong Canc Hosp & Inst, Dept Radiat Oncol, Jinan 250117, Shandong, Peoples R China.
EM yaozhi@tmu.edu.cn; fuzhengcn@vip.sina.com; wsh5635@163.com
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NR 83
TC 0
Z9 0
U1 0
U2 0
PU BENTHAM SCIENCE PUBL LTD
PI SHARJAH
PA EXECUTIVE STE Y-2, PO BOX 7917, SAIF ZONE, 1200 BR SHARJAH, U ARAB
   EMIRATES
SN 1570-159X
EI 1875-6190
J9 CURR NEUROPHARMACOL
JI Curr. Neuropharmacol.
PD 2025 DEC 19
PY 2025
DI 10.2174/011570159X417392251118050138
EA DEC 2025
PG 16
WC Neurosciences; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology; Pharmacology & Pharmacy
GA FN8WW
UT WOS:001723214100001
PM 41879438
DA 2026-05-27
ER

PT J
AU Takeda, Y
   Isai, N
   Masuda, T
   Honda, G
   Takaishi, Y
   Ito, M
   Otsuka, H
   Ashurmetov, OA
   Khodzhimatov, OK
AF Takeda, Y
   Isai, N
   Masuda, T
   Honda, G
   Takaishi, Y
   Ito, M
   Otsuka, H
   Ashurmetov, OA
   Khodzhimatov, OK
TI Phlomisflavosides A and B, new flavonol bisglycosides from Phlomis
   spinidens
SO CHEMICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE Phlomis spinidens; Labiatae; phlomisflavoside a; phlomisflavoside B;
   flavanol bisglycoside
ID PHENYLETHANOID GLYCOSIDE; IRIDOID GLUCOSIDES; CONSTITUENTS;
   YOUNGHUSBANDII; SPECTABILIS; ROOTS
AB From the aerial parts of Phlomis spinidens, two new flavonol bisglycosides, phlomisflavosides A (1) and B (2). were isolated together with the known compounds, astragalin, isoquercitrin, lamiridoside, phlomoside A, shanzhiside methyl ester, 8-O-acetylshanzhiside methyl ester, phlorigidoside C, rodioloside (=salidroside), forsythoside B, citroside A and lariciresinol-4'-O-beta -D-glucoside. The structures of the new compounds were elucidated based on spectral and chemical evidence.
C1 Univ Tokushima, Fac Integrated Arts & Sci, Tokushima 7708502, Japan.
   Kyoto Univ, Grad Sch Pharmaceut Sci, Sakyo Ku, Kyoto 6068501, Japan.
   Univ Tokushima, Fac Pharmaceut Sci, Tokushima 7708505, Japan.
   Hiroshima Univ, Fac Med, Inst Pharmaceut Sci, Minami Ku, Hiroshima 7348551, Japan.
   Uzbek Acad Sci, Inst Bot, Tashkent 700143, Uzbekistan.
   Uzbek Acad Sci, Bot Garden, Tashkent 700143, Uzbekistan.
C3 Tokushima University; Kyoto University; Tokushima University; Hiroshima
   University; Academy of Sciences of Uzbekistan; Institute of Botany,
   Uzbekistan; Academy of Sciences of Uzbekistan; Institute of Botany,
   Uzbekistan
RP Takeda, Y (corresponding author), Univ Tokushima, Fac Integrated Arts & Sci, Tokushima 7708502, Japan.
EM takeda@ias.tokushima-u.ac.jp
RI ; Olim, Khojimatov/AAT-1910-2020; Masuda, Toshiya/AAB-5720-2019
OI Ito, Michiho/0000-0001-9821-0628; Olim, Khojimatov/0000-0003-1631-8841;
   Masuda, Toshiya/0000-0001-6691-9464
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NR 23
TC 16
Z9 20
U1 0
U2 8
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0009-2363
J9 CHEM PHARM BULL
JI Chem. Pharm. Bull.
PD AUG
PY 2001
VL 49
IS 8
BP 1039
EP 1041
DI 10.1248/cpb.49.1039
PG 3
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA 456YM
UT WOS:000170110400022
PM 11515576
OA Bronze
DA 2026-05-27
ER

PT J
AU Xu, LN
   Jia, LB
   Wang, QY
   Hou, J
   Li, SF
   Teng, JF
AF Xu, Lina
   Jia, Longbin
   Wang, Qingyun
   Hou, Jing
   Li, Shifang
   Teng, Junfang
TI Salidroside attenuates hypoxia/reoxygenation-induced human brain
   vascular smooth muscle cell injury by activating the SIRT1/FOXO3α
   pathway
SO EXPERIMENTAL AND THERAPEUTIC MEDICINE
LA English
DT Article
DE salidroside; hypoxia/reoxygenation; silent information regulator 1;
   forkhead box protein O3 alpha; neuroprotection
ID INFORMATION REGULATOR 1; CEREBRAL-ISCHEMIA; ISCHEMIA/REPERFUSION INJURY;
   TRANSCRIPTION FACTORS; EXPERIMENTAL STROKE; ALZHEIMERS-DISEASE;
   OXIDATIVE STRESS; RAT MODEL; PROTECTS; SIRT1
AB It has been reported that salidroside (SAL), a natural dietary isothiocyanate, exhibits neuroprotective roles in cerebral ischemia-reperfusion injury. However, to the best of our knowledge, its underlying protective mechanism remains unknown. Sirtuin 1 (SIRT1) is a class III histone deacetylase involved in a variety of cellular functions. SIRT1 has been identified as a mediator of cerebral ischemia and may induce neuroprotection by activating various intracellular downstream targets, such as forkhead box protein O3 alpha (FOXO3 alpha). Therefore, the present study aimed to investigate whether SAL protects human brain vascular smooth muscle cells (HBVSMC) against hypoxia/reoxygenation (H/R) injury, which is a cell model of cerebral ischemia-reperfusion injury, through regulating the SIRT1-activited signaling pathway. The present study revealed that H/R treatment significantly reduced the expression of SIRT1 protein in HBVSMCs. Additionally, pretreatment with SAL reversed the H/R-induced decrease in cellular viability, increased caspase-3 activity, the appearance of apoptotic cells and the apoptosis rate in HBVSMCs. SAL attenuated the H/R-induced decrease in the expression of SIRT1 and phosphorylated FOXO3 alpha protein in HBVSMCs, suggesting that the protective role of SAL in H/R injury occurs via the SIRT1/FOXO3 alpha pathway. Furthermore, sirtinol, a SIRT1-specific inhibitor, suppressed the inhibitory effects of SAL on H/R-induced cytotoxicity and apoptosis as indicated by the downregulation of cell viability and upregulation of caspase-3 activity and apoptosis rate induced by sirtinol treatment in HBVSMCs. The reversal effects of SAL on H/R-induced alternation of B-cell lymphoma (Bcl-2) and Bcl-2 associated X protein expression were also attenuated by sirtinol. These results suggest that SAL exhibits neuroprotective effects against H/R injury by activating the SIRT1/FOXO3 alpha pathway, which may become a novel potential therapeutic target for the treatment of cerebral ischemic disease.
C1 [Xu, Lina; Jia, Longbin; Wang, Qingyun; Hou, Jing; Li, Shifang] Jincheng Peoples Hosp, Dept Neurol, Jincheng 048026, Shanxi, Peoples R China.
   [Xu, Lina; Teng, Junfang] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, 40 Daxue Rd, Zhengzhou 450000, Henan, Peoples R China.
C3 Zhengzhou University
RP Teng, JF (corresponding author), Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, 40 Daxue Rd, Zhengzhou 450000, Henan, Peoples R China.
EM tengjunfang0101@sina.com
FU First Affiliated Hospital of Zhengzhou University
FX This study was supported by a grant from the First Affiliated Hospital
   of Zhengzhou University.
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NR 52
TC 17
Z9 20
U1 0
U2 17
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1792-0981
EI 1792-1015
J9 EXP THER MED
JI Exp. Ther. Med.
PD JAN
PY 2018
VL 15
IS 1
BP 822
EP 830
DI 10.3892/etm.2017.5446
PG 9
WC Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Research & Experimental Medicine
GA FV0WL
UT WOS:000424281600118
PM 29434685
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Chen, BB
   Wang, LL
   Li, L
   Zhu, RY
   Liu, HX
   Liu, CY
   Ma, RF
   Jia, QQ
   Zhao, DD
   Niu, JZ
   Fu, M
   Gao, SH
   Zhang, DW
AF Chen, Beibei
   Wang, Lili
   Li, Lin
   Zhu, Ruyuan
   Liu, Haixia
   Liu, Chenyue
   Ma, Rufeng
   Jia, Qiangqiang
   Zhao, Dandan
   Niu, Jianzhao
   Fu, Min
   Gao, Sihua
   Zhang, Dongwei
TI Fructus Ligustri Lucidi in Osteoporosis: A Review of its
   Pharmacology, Phytochemistry, Pharmacokinetics and Safety
SO MOLECULES
LA English
DT Review
DE Fructus Ligustri Lucidi (FLL); osteoporosis; pharmacology;
   phytochemistry; pharmacokinetics; safety
ID CHINESE HERBAL MEDICINE; SERUM PARATHYROID-HORMONE; BONE-MINERAL
   DENSITY; ETHANOL EXTRACT; OLEANOLIC ACID; URSOLIC ACID; VITAMIN-D;
   OVARIECTOMIZED RATS; CALCIUM-ABSORPTION; LIPID-METABOLISM
AB Background: Fructus Ligustri Lucidi (FLL) has now attracted increasing attention as an alternative medicine in the prevention and treatment of osteoporosis. This study aimed to provide a general review of traditional interpretation of the actions of FLL in osteoporosis, main phytochemical constituents, pharmacokinetics, pharmacology in bone improving effect, and safety. Materials and Methods: Several databases, including PubMed, China National Knowledge Infrastructure, National Science and Technology Library, China Science and Technology Journal Database, and Web of Science were consulted to locate publications pertaining to FLL. The initial inquiry was conducted for the presence of the following keywords combinations in the abstracts: Fructus Ligustri Lucidi, osteoporosis, phytochemistry, pharmacokinetics, pharmacology, osteoblasts, osteoclasts, salidroside. About 150 research papers and reviews were consulted. Results: FLL is assumed to exhibit anti-osteoporotic effects by improving liver and kidney deficiencies and reducing lower back soreness in Traditional Chinese Medicine (TCM). The data from animal and cell experiments demonstrate that FLL is able to improve bone metabolism and bone quality in ovariectomized, growing, aged and diabetic rats through the regulation of PTH/FGF-23/1,25-(OH)(2)D-3/CaSR, Nox4/ROS/NF-kappa B, and OPG/RANKL/cathepsin K signaling pathways. More than 100 individual compounds have been isolated from this plant. Oleanolic acid, ursolic acid, salidroside, and nuzhenide have been reported to exhibit the anti-osteoporosis effect. The pharmacokinetics data reveals that salidroside is one of the active constituents, and that tyrosol is hard to detect under physiological conditions. Acute and subacute toxicity studies show that FLL is well tolerated and presents no safety concerns. Conclusions: FLL provides a new option for the prevention and treatment of osteoporosis, which attracts rising interests in identifying potential anti-osteoporotic compounds and fractions from this plant. Further scientific evidences are expected from well-designed clinical trials on its bone protective effects and safety.
C1 [Chen, Beibei; Li, Lin; Zhu, Ruyuan; Liu, Haixia; Ma, Rufeng; Jia, Qiangqiang; Niu, Jianzhao] Beijing Univ Chinese Med, Tradit Chinese Med Sch, Beijing 100029, Peoples R China.
   [Wang, Lili; Liu, Chenyue] Beijing Univ Chinese Med, Chinese Mat Medica Sch, Beijing 100029, Peoples R China.
   [Wang, Lili; Zhao, Dandan; Gao, Sihua; Zhang, Dongwei] Beijing Univ Chinese Med, Diabet Res Ctr, Beijing 100029, Peoples R China.
   [Fu, Min] McGill Univ, Ctr Hlth, Res Inst, Montreal, PQ H4A 3J1, Canada.
C3 Beijing University of Chinese Medicine; Beijing University of Chinese
   Medicine; Beijing University of Chinese Medicine; McGill University
RP Zhang, DW (corresponding author), Beijing Univ Chinese Med, Diabet Res Ctr, Beijing 100029, Peoples R China.
EM cbb8969@163.com; wangxiaoxing0108@163.com; lilin19930901@163.com;
   zhuruyuan7@163.com; lhx8866_7@163.com; liuchenyue633@163.com;
   marufeng5188@126.com; jiaqiangqiang1234@163.com; bucmzhaodandan@163.com;
   niujianzhao@126.com; fumin1025@gmail.com; gaosihua1216@163.com;
   dongwei1006@gmail.com
RI Zhang, Dongwei/AAS-8384-2020; /AAS-6452-2021
FU Beijing Municipal Natural Science Foundation [7172126]; National Natural
   Science Foundation of China [NSFC81273995, NSFC81274041]; Beijing
   Chaoyang Collaborative Innovation project [CYXC1513]; key drug
   development program of MOST [20122X09103201-005]; 111 project of MOE
   [B07007]
FX This work was supported by Grants from Beijing Municipal Natural Science
   Foundation (7172126), National Natural Science Foundation of China
   (NSFC81273995, NSFC81274041), Beijing Chaoyang Collaborative Innovation
   project (CYXC1513), and key drug development program of MOST
   (20122X09103201-005) as well as the 111 project of MOE (B07007).
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NR 109
TC 58
Z9 66
U1 2
U2 71
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1420-3049
J9 MOLECULES
JI Molecules
PD SEP
PY 2017
VL 22
IS 9
AR 1469
DI 10.3390/molecules22091469
PG 17
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA FH9AV
UT WOS:000411499400173
PM 28872612
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Gao, J
   Zhou, R
   You, XT
   Luo, F
   He, H
   Chang, XY
   Zhu, LP
   Ding, XS
   Yan, TH
AF Gao, Jin
   Zhou, Rui
   You, Xintong
   Luo, Fen
   He, He
   Chang, Xiayun
   Zhu, Lingpeng
   Ding, Xuansheng
   Yan, Tianhua
TI Salidroside suppresses inflammation in a D-galactose-induced rat model
   of Alzheimer's disease via SIRT1/NF-κB pathway
SO METABOLIC BRAIN DISEASE
LA English
DT Article
DE Sal; Aging; Cognitive impairment; Neuroinflammation; SIRT1/NF-kappa B
   pathway
ID NF-KAPPA-B; OXIDATIVE STRESS; COGNITIVE IMPAIRMENT; SIRT1; PROTECTS;
   BRAIN; MICE; NEURODEGENERATION; TRANSCRIPTION; INHIBITION
AB Age-related inflammation is the predominant factor for neurodegenerative diseases like Alzheimer's disease (AD). In the present study, we examined memory performance and neuroinflammation in D-galactose (D-gal)-induced sub-acute aging model of rats. Our results demonstrated that chronic administration of D-gal (120 mg/kg) produced cognitive impairment as determined by Morris water maze (MWM) test and step-down passive avoidance test. D-gal also activated nuclear factor kappa B (NF-kappa B) p65/RelA by down-regulating the expression level of sirtuins 1 (SIRT1) in the hippocampus. Treatment with Salidroside (Sal, 20, 40 mg/kg) for 28 days ameliorated D-gal-induced memory deficits and inflammatory mediators including tumor necrosis factor-alpha (TNF-alpha) and interleukin-1 beta (IL-1 beta). Moreover, D-gal-induced activation of NF-kappa B signaling pathway in the brain was also inhibited by Sal via up-regulating SIRT1. These results suggest that D-gal-triggered memory impairment and inflammatory response may be associated with SIRT1/NF-kappa B signaling pathway, whereas treatment with Sal could positively affect these changes in hippocampus.
C1 [Gao, Jin; Zhou, Rui; Luo, Fen; He, He; Chang, Xiayun; Zhu, Lingpeng; Yan, Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Peoples R China.
   [You, Xintong] Nanjing Forestry Univ, Dept Polymer Mat & Engn, Nanjing 210037, Jiangsu, Peoples R China.
   [Ding, Xuansheng] China Pharmaceut Univ, Dept Clin Pharm, Nanjing 210009, Peoples R China.
   [Ding, Xuansheng; Yan, Tianhua] China Pharmaceut Univ, Tongjiaxiang 24, Nanjing, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; Nanjing Forestry University; China
   Pharmaceutical University; China Pharmaceutical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing 210009, Peoples R China.; Ding, XS (corresponding author), China Pharmaceut Univ, Dept Clin Pharm, Nanjing 210009, Peoples R China.; Ding, XS; Yan, TH (corresponding author), China Pharmaceut Univ, Tongjiaxiang 24, Nanjing, Jiangsu, Peoples R China.
EM dxs0162@sina.com; yantianhuabest@126.com
RI Su, Tianyuan/Y-7054-2019; he, he/JPL-3505-2023; zhou, rui/KZT-9353-2024
FU National twelve five major drug discovery project [2011ZX09102-002-01]
FX This work was supported by National twelve five major drug discovery
   project (2011ZX09102-002-01).
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NR 39
TC 124
Z9 147
U1 0
U2 66
PU SPRINGER/PLENUM PUBLISHERS
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0885-7490
EI 1573-7365
J9 METAB BRAIN DIS
JI Metab. Brain Dis.
PD AUG
PY 2016
VL 31
IS 4
BP 771
EP 778
DI 10.1007/s11011-016-9813-2
PG 8
WC Endocrinology & Metabolism; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Neurosciences & Neurology
GA DQ4QH
UT WOS:000379187900005
PM 26909502
DA 2026-05-27
ER

PT J
AU Ma, WD
   Wang, ZY
   Zhao, Y
   Wang, QB
   Zhang, YH
   Lei, P
   Lu, W
   Yan, S
   Zhou, J
   Li, XJ
   Yu, WJ
   Zhong, YX
   Chen, L
   Zheng, T
AF Ma, Weidong
   Wang, Ziyuan
   Zhao, Yan
   Wang, Qibin
   Zhang, Yonghong
   Lei, Pan
   Lu, Wei
   Yan, Shan
   Zhou, Jun
   Li, Xiaojiao
   Yu, Wenjun
   Zhong, Yaoxin
   Chen, Li
   Zheng, Tao
TI Salidroside Suppresses the Proliferation and Migration of Human Lung
   Cancer Cells through AMPK-Dependent NLRP3 Inflammasome Regulation
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID OXIDATIVE STRESS; ACTIVATION; METASTASIS; INHIBITION
AB Inflammatory reactions mediated by the NACHT, LRR, and PYD domain-containing protein 3 (NLRP3) inflammasome contributes to non-small-cell lung cancer (NSCLC) progression, particularly in patients with bacterial infections. Salidroside (SAL) has recently been shown to suppress lipopolysaccharide- (LPS-) induced NSCLC proliferation and migration, but its mechanism of action remains unclear. It has been shown that SAL improves metabolic inflammation in diabetic rodents through AMP-activated protein kinase- (AMPK-) dependent inhibition of the NLRP3 inflammasome. However, whether the NLRP3 inflammasome is regulated by SAL in NSCLC cells and how its underlying mechanism(s) can be determined require clarification. In this study, human lung alveolar basal carcinoma epithelial (A549) cells were treated with LPS, and the effects of SAL on cell proliferation, migration, AMPK activity, reactive oxygen species (ROS) production, and NLRP3 inflammasome activation were investigated. We found that LPS induction increases the proliferation and migration of A549 cells which was suppressed by SAL. Moreover, SAL protected A549 cells against LPS-induced AMPK inhibition, ROS production, and NLRP3 inflammasome activation. Blocking AMPK using Compound C almost completely suppressed the beneficial effects of SAL. In summary, these results indicate that SAL suppresses the proliferation and migration of human lung cancer cells through AMPK-dependent NLRP3 inflammasome regulation.
C1 [Ma, Weidong; Wang, Ziyuan; Zhao, Yan; Zhang, Yonghong; Lei, Pan; Yan, Shan; Zhou, Jun; Li, Xiaojiao; Yu, Wenjun; Zhong, Yaoxin; Chen, Li; Zheng, Tao] Hubei Univ Med, Taihe Hosp, Inst Wudang Tradit Chinese Med, Shiyan, Hubei, Peoples R China.
   [Wang, Qibin; Lu, Wei; Chen, Li; Zheng, Tao] Hubei Univ Med, Taihe Hosp, Dept Pharm, Shiyan, Hubei, Peoples R China.
   [Lei, Pan] Hubei Univ Med, Hubei Key Lab Wudang Local Chinese Med Res, Shiyan, Hubei, Peoples R China.
C3 Hubei University of Medicine; Hubei University of Medicine; Hubei
   University of Medicine
RP Zheng, T (corresponding author), Hubei Univ Med, Taihe Hosp, Inst Wudang Tradit Chinese Med, Shiyan, Hubei, Peoples R China.; Zheng, T (corresponding author), Hubei Univ Med, Taihe Hosp, Dept Pharm, Shiyan, Hubei, Peoples R China.
EM ztice@foxmail.com
RI Zheng, Tao/JOZ-1467-2023
OI Zheng, Tao/0000-0003-1742-1357
FU National Natural Science Foundation of China [81703582]; Hubei
   Provincial Natural Science Foundation of China [2016CFB153, 2020CFB713];
   Health Commission of Hubei Province Scientific Research Project
   [WJ2019M057]; Innovative Research Program for Graduates of Hubei
   University of Medicine [YC2021036, YC2021022, YC2021025, YC2019029]
FX This work was supported by grants from the National Natural Science
   Foundation of China (81703582), the Hubei Provincial Natural Science
   Foundation of China (2016CFB153 and 2020CFB713), the Health Commission
   of Hubei Province Scientific Research Project (WJ2019M057), and the
   Innovative Research Program for Graduates of Hubei University of
   Medicine (YC2021036, YC2021022, YC2021025, and YC2019029).
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NR 49
TC 34
Z9 39
U1 0
U2 20
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD AUG 19
PY 2021
VL 2021
AR 6614574
DI 10.1155/2021/6614574
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA UJ2SI
UT WOS:000691141300003
PM 34457117
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Lin, YJ
   Ma, XL
   Zhang, L
   Gu, H
   Fu, X
   Li, PW
AF Lin, Yujie
   Ma, Xiangli
   Zhang, Ling
   Gu, Hao
   Fu, Xu
   Li, Peiwu
TI Investigating the Role of Salidroside in Alleviating Acute Pancreatitis
   by Inhibiting the RIPK1/RIPK3/ MLKL Pathway-Mediated Necroptosis in
   Pancreatic Acinar Cells in Rats
SO JOURNAL OF INFLAMMATION RESEARCH
LA English
DT Article
DE acute pancreatitis; salidroside; necroptosis; RIPK1/RIPK3/MLKL pathway;
   mitochondrial dysfunction
ID INJURY
AB Background: Necroptosis, a regulated form of cell death, is a key driver of pancreatic injury in acute pancreatitis (AP). Salidroside (Sal), a natural compound known for its antioxidant properties, was investigated for its potential to alleviate AP by targeting the necroptotic pathway.<br /> Methods: An AP model was induced in Wistar rats via retrograde infusion of 3.5% sodium taurocholate into the pancreatic duct. Rats were randomly divided into three groups: sham, AP model, and AP + Sal (60 mg/kg). Serum levels of amylase (AMY) and inflammatory cytokines (IL-6, IL-1 beta, TNF-alpha) were measured, and pancreatic tissue damage was assessed. The involvement of the RIPK1/RIPK3/MLKL pathway and mitochondrial ultrastructure were analyzed by Western blot, immunohistochemistry (IHC), and transmission electron microscopy (TEM). An in vitro AP model was established in AR42J cells using cerulein (100 nM). Cells were pretreated with Sal or Necrostatin-1 (Nec-1), and mitochondrial membrane potential, necroptosis-related protein expression, and p-MLKL subcellular localization were examined.<br /> Results: Sal treatment significantly reduced serum AMY levels (p < 0.01) and pro-inflammatory cytokines (IL-6, IL-1 beta, TNF-alpha; all p < 0.05) in AP rats. Histopathological analysis revealed that Sal markedly ameliorated pancreatic tissue edema, inflammatory infiltration, and necrosis (p < 0.01). Western blot analysis showed that Sal significantly inhibited the expression of key necroptosis-related proteins (RIPK1, RIPK3, and p-MLKL) in both pancreatic tissue and AR42J cells (all p < 0.05). IHC and immunofluorescence confirmed that Sal effectively suppressed p-MLKL membrane translocation (p < 0.01). TEM further demonstrated that Sal preserved mitochondrial structural integrity. However, in vitro, the combination of Sal and Nec-1 did not produce a significant additive effect.<br /> Conclusion: Sal alleviates experimental AP by inhibiting necroptosis, likely through targeting the RIPK1/RIPK3/MLKL pathway and preserving mitochondrial function. These findings suggest that Sal is a promising therapeutic candidate for AP treatment.
C1 [Lin, Yujie; Ma, Xiangli; Zhang, Ling; Fu, Xu; Li, Peiwu] Lanzhou Univ, Hosp 2, Dept Emergency, Lanzhou 730030, Peoples R China.
   [Lin, Yujie; Ma, Xiangli; Zhang, Ling; Gu, Hao; Fu, Xu; Li, Peiwu] Lanzhou Univ, Clin Med Sch, Lanzhou 730030, Peoples R China.
   [Gu, Hao] Lanzhou Univ, Hosp 2, Dept Vasc Surg, Lanzhou 730030, Peoples R China.
C3 Lanzhou University; Lanzhou University; Lanzhou University
RP Li, PW (corresponding author), Lanzhou Univ, Hosp 2, Dept Emergency, Lanzhou 730030, Peoples R China.; Li, PW (corresponding author), Lanzhou Univ, Clin Med Sch, Lanzhou 730030, Peoples R China.
EM lipeiw@lzu.edu.cn
RI yujie, lin/P-8141-2019
FU National Natural Science Foundation of China [82260135]; Science and
   Technology Program of Gansu Province [22YF7WA087]
FX This work was supported by the National Natural Science Foundation of
   China (82260135) and Science and Technology Program of Gansu Province
   (22YF7WA087) .
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NR 32
TC 0
Z9 0
U1 1
U2 1
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
EI 1178-7031
J9 J INFLAMM RES
JI J. Inflamm. Res.
PY 2025
VL 18
BP 14857
EP 14869
DI 10.2147/JIR.S545785
PG 13
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 8ZW2O
UT WOS:001601288100001
PM 41181365
OA Green Accepted, gold
DA 2026-05-27
ER

PT J
AU Cai, YW
   Chai, YH
   Fu, Y
   Wang, YD
   Zhang, YM
   Zhang, X
   Zhu, LP
   Miao, MX
   Yan, TH
AF Cai, Yawen
   Chai, Yuhui
   Fu, Yu
   Wang, Yingdi
   Zhang, Yiming
   Zhang, Xue
   Zhu, Lingpeng
   Miao, Mingxing
   Yan, Tianhua
TI Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3
   Inflammasome-Mediated Pyroptosis
SO FRONTIERS IN AGING NEUROSCIENCE
LA English
DT Article
DE Alzheimer's disease; salidroside; pyroptosis; NLRP3 inflammasome; TLR4
ID AMYLOID-BETA; COGNITIVE FUNCTION; MECHANISMS; MICE; FERROPTOSIS;
   IMPAIRMENT; ACTIVATION; REGULATOR; ALUMINUM; PATHWAY
AB Amyloid beta-protein (A beta) is reported to activate NLRP3 inflammasomes and drive pyroptosis, which is subsequently involved in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease (AD). To date, the pathogenesis of AD is unfortunately insufficiently elucidated. Therefore, this study was conducted to explore whether Salidroside (Sal) treatment could benefit AD by improving pyroptosis. Firstly, two animal models of AD, induced, respectively, by A beta 1-42 and D-galactose (D-gal)/AlCl3, have been created to assist our appreciation of AD pathophysiology. We then confirmed that pyroptosis is related to the pathogenesis of AD, and Sal can slow the progression of AD by inhibiting pyroptosis. Subsequently, we established the D-gal and Nigericin-induced PC12 cells injury model in vitro to verify Sal blocks pyroptosis mainly by targeting the NLRP3 inflammasome. For in vivo studies, we observed that A beta accumulation, Tau hyperphosphorylation, neurons of hippocampal damage, and cognitive dysfunction in AD mice, caused by bilateral injection of A beta 1-42 into the hippocampus and treatments with D-gal combine AlCl3. Besides, accumulated A beta promotes NLRP3 inflammasome activation, which leads to the activation and release of a pro-inflammatory cytokine, interleukin-1 beta (IL-1 beta). Notably, both A beta accumulation and hyperphosphorylation of Tau decreased and inhibited pyroptosis by downregulating the expression of IL-1 beta and IL-18, which can be attributed to the treatment of Sal. We further found that Sal can reverse the increased protein expression of TLR4, MyD88, NF-kappa B, P-NF-kappa B, NLRP3, ASC, cleaved Caspase-1, cleaved GSDMD, IL-1 beta, and IL-18 in vitro. The underlying mechanism may be through inhibiting TLR4/NF-kappa B/NLRP3/Caspase-1 signaling pathway. Our study highlights the importance of NLRP3 inflammasome-mediated pyroptosis in AD, and how the administration of pharmacological doses of Sal can inhibit NLRP3 inflammasome-mediated pyroptosis and ameliorate AD. Thus, we conclude that NLRP3 inflammasome-mediated pyroptosis plays a significant role in AD and Sal could be a therapeutic drug for AD.
C1 [Cai, Yawen; Chai, Yuhui; Fu, Yu; Wang, Yingdi; Zhang, Yiming; Zhang, Xue; Yan, Tianhua] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Dept Physiol & Pharmacol, Nanjing, Peoples R China.
   [Zhu, Lingpeng] Nanjing Med Univ, Ctr Clin Res, Affiliated Wuxi Peoples Hosp, Wuxi, Peoples R China.
   [Miao, Mingxing] China Pharmaceut Univ, Ctr Natl Pharmaceut Expt Teaching Demonstrat, Nanjing, Peoples R China.
C3 China Pharmaceutical University; Nanjing Medical University; China
   Pharmaceutical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Dept Physiol & Pharmacol, Nanjing, Peoples R China.; Zhu, LP (corresponding author), Nanjing Med Univ, Ctr Clin Res, Affiliated Wuxi Peoples Hosp, Wuxi, Peoples R China.; Miao, MX (corresponding author), China Pharmaceut Univ, Ctr Natl Pharmaceut Expt Teaching Demonstrat, Nanjing, Peoples R China.
EM zhulingpeng@njmu.edu.cn; mmx0224@163.com; 1020050806@cpu.edu.cn
RI ; Su, Tianyuan/Y-7054-2019; yingdi, Wang/OEN-1592-2025; Cai,
   Yawen/OKR-6198-2025
OI Yan, Tianhua/0000-0001-6124-8630; Zhu, Lingpeng/0000-0003-0762-4038; 
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NR 75
TC 130
Z9 146
U1 8
U2 148
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-4365
J9 FRONT AGING NEUROSCI
JI Front. Aging Neurosci.
PD JAN 21
PY 2022
VL 13
AR 809433
DI 10.3389/fnagi.2021.809433
PG 22
WC Geriatrics & Gerontology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Geriatrics & Gerontology; Neurosciences & Neurology
GA YT3SS
UT WOS:000751284200001
PM 35126093
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yuan, Y
   Wu, SJ
   Liu, X
   Zhang, LL
AF Yuan, Yuan
   Wu, Si-Jia
   Liu, Xin
   Zhang, Lu-Lu
TI Antioxidant effect of salidroside and its protective effect against
   furan-induced hepatocyte damage in mice
SO FOOD & FUNCTION
LA English
DT Article
ID TOXICITY; FOODS; ASSAY
AB Furan, a widely used industrial compound, has been found in many heat-treated foods, especially baby food. The presence of furan in food raises concerns about public health. In this study, we evaluated the protective effect of salidroside (SR) against furan-induced hepatocyte damage in mice livers. The in vitro antioxidant effects of SR were also evaluated. The results suggested that furan significantly increased hepatocyte damage, as proven by the increased activities of aminotransferase (AST), alanine aminotransferase (ALT) and levels of direct bilirubin (DBIL). Furan also caused oxidative stress, as evidenced by increased reactive oxygen species (ROS) production as well as malondialdehyde (MDA) levels and glutathione S-transferase (GST) activity in mice livers. Pretreatment with SR markedly attenuated the activities of AST, ALT, GST and the levels of DBIL, ROS, and MDA in a dose-dependent manner. The protective effects of SR against furan-induced hepatocyte damage were due to its excellent ability to scavenge free radicals such as 2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) radicals, (OH)-O-center dot, 2,2-di(4-tert-octylphenyl)-1-picrylhydrazyl radicals and O-center dot(2)-. Thus, SR exerted excellent antioxidant effects, and it may be a novel therapeutic and preventive agent for oxidative stress-related diseases.
C1 [Yuan, Yuan; Wu, Si-Jia; Zhang, Lu-Lu] Jilin Univ, College Quartermaster Technol, Changchun 130062, Peoples R China.
   [Liu, Xin] China Agr Univ, Coll Food Sci & Nutr Engn, Beijing 100083, Peoples R China.
C3 Jilin University; China Agricultural University
RP Yuan, Y (corresponding author), Jilin Univ, College Quartermaster Technol, Changchun 130062, Peoples R China.
EM yuanyuan1024@gmail.com
RI yuan, Yuan/ISA-0923-2023
FU Fund of National High Technology Research and Development Program of
   China ("863" Project) [2011AA100806]; National Basic Research Program of
   China ("973" Program) [2012CB720805]; Fund for Distinguished Young
   Scholars of Heping Campus of Jilin University [4305050102Q9]
FX This work was supported by the Fund of National High Technology Research
   and Development Program of China ("863" Project, 2011AA100806), the
   National Basic Research Program of China ("973" Program, 2012CB720805),
   and the Fund for Distinguished Young Scholars of Heping Campus of Jilin
   University (4305050102Q9). Accordingly, the authors gratefully
   acknowledge the financial support.
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NR 29
TC 60
Z9 66
U1 0
U2 53
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD MAY
PY 2013
VL 4
IS 5
BP 763
EP 769
DI 10.1039/c3fo00013c
PG 7
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA 135QD
UT WOS:000318302700011
PM 23507802
DA 2026-05-27
ER

PT J
AU Chen, PS
   Liu, J
   Ruan, HY
   Zhang, MM
   Wu, P
   Du, YM
   Han, B
AF Chen, Pengsheng
   Liu, Jia
   Ruan, Hongyun
   Zhang, Miaomiao
   Wu, Peng
   Du Yimei
   Han, Bing
TI Protective effects of Salidroside on cardiac function in mice with
   myocardial infarction
SO SCIENTIFIC REPORTS
LA English
DT Article
ID VEGF-MEDIATED ANGIOGENESIS; NITRIC-OXIDE SYNTHASE; INFLAMMATORY
   RESPONSE; RHODIOLA-ROSEA; IN-VITRO; KAPPA-B; ACTIVATION; APOPTOSIS; AKT;
   SUBSTRATE
AB Salidroside (SAL) is the major ingredient of Rhodiola rosea, and has been traditionally used in Chinese medicine for decades. Numerous studies have demonstrated the protective effects of SAL for myocardial ischemia. However, it is yet to be deciphered whether SAL has cardioprotective effects after myocardial infarction (MI) in vivo. In the present study, we established a mouse MI model via coronary artery ligation. The aim was to investigate whether SAL treatment could reduce mortality, improve cardiac function and attenuate myocardial remodeling in MI mice. Post-surgery, mice were randomly administered SAL or normal saline. After 21 days, SAL was found to significantly reduce mortality, improve cardiac function, reduce fibrosis and infarct size compared to normal saline. In addition, oral administration of SAL could attenuate myocardial inflammation and apoptosis and promote angiogenesis. SAL down-regulated the expression levels of TNF-alpha, TGF-beta 1, IL-1 beta, Bax and upregulate the expression of Bcl-2, VEGF, Akt and eNOS. These results indicated that SAL could alleviate the pathological processes of myocardial remodeling in MI mice, and may be a potentially effective therapeutic approach for the management of clinical ischemic cardiovascular diseases.
C1 [Chen, Pengsheng; Ruan, Hongyun; Zhang, Miaomiao; Han, Bing] Nanjing Med Univ, Xuzhou Clin Sch, XuZhou Inst Cardiovasc Dis, Dept Cardiol,XuZhou Cent Hosp, Xuzhou 221009, Jiangsu, Peoples R China.
   [Liu, Jia] Nanjing Med Univ, Xuzhou Clin Sch, XuZhou Cent Hosp, Dept Clin Lab, Xuzhou 221009, Jiangsu, Peoples R China.
   [Wu, Peng] Nanjing Med Univ, Affiliated Hosp 1, Dept Cardiol, Nanjing 210029, Jiangsu, Peoples R China.
   [Du Yimei] Wuhan Union Hosp, Dept Cardiol, Wuhan 430000, Hubei, Peoples R China.
C3 Nanjing Medical University; Southeast University - China; Southeast
   University - China; Nanjing Medical University; Nanjing Medical
   University; Huazhong University of Science & Technology
RP Han, B (corresponding author), Nanjing Med Univ, Xuzhou Clin Sch, XuZhou Inst Cardiovasc Dis, Dept Cardiol,XuZhou Cent Hosp, Xuzhou 221009, Jiangsu, Peoples R China.
EM Binghan2019@163.com
RI Du, Yimei/K-3232-2019
FU science and technology planning project of Xuzhou [KC17125]
FX This work was supported by a grant from the science and technology
   planning project of Xuzhou (KC17125).
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NR 47
TC 44
Z9 50
U1 1
U2 24
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD DEC 2
PY 2019
VL 9
AR 18127
DI 10.1038/s41598-019-54713-x
PG 11
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA JT0QU
UT WOS:000500704500001
PM 31792327
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Abdou, MM
   O'Neill, PM
   Amigues, E
   Matziari, M
AF Abdou, Moaz M.
   O'Neill, Paul M.
   Amigues, Eric
   Matziari, Magdalini
TI Unprecedented Convergent Synthesis of Sugar-Functionalization of
   Phosphinic Acids under Metal-Free Conditions
SO ACS OMEGA
LA English
DT Article
ID SOLID-PHASE SYNTHESIS; SALIDROSIDE; GLUCOSE; ANTIOXIDANT; MIGRATION;
   ALPHA
AB A novel TEA-catalyzed sugar-esterification of phosphinic acids was used as a general and efficient approach for the synthesis of a variety of phosphinates without any transition metal. The high efficiency of the current methodology and a convenient experimental procedure compensate for the moderate yields obtained. Another advantage is that the reaction tolerates different substituents attached to the phosphinic acids and the sugar moieties alongside the ease of isolation of the product.
C1 [O'Neill, Paul M.] Univ Liverpool, Dept Chem, Liverpool L69 7ZD, Merseyside, England.
   [Amigues, Eric; Matziari, Magdalini] Xian Jiaotong Liverpool Univ, Dept Chem, Suzhou 215123, Jiangsu, Peoples R China.
   [Abdou, Moaz M.] Egyptian Petr Res Inst, Cairo 11727, Egypt.
C3 University of Liverpool; Xi'an Jiaotong-Liverpool University; Egyptian
   Knowledge Bank (EKB); Egyptian Petroleum Research Institute (EPRI)
RP Matziari, M (corresponding author), Xian Jiaotong Liverpool Univ, Dept Chem, Suzhou 215123, Jiangsu, Peoples R China.; Abdou, MM (corresponding author), Egyptian Petr Res Inst, Cairo 11727, Egypt.
EM moaz.chem@gmail.com; Magdalini.Matziari@xjtlu.edu.cn
RI Abdou, Moaz/D-1226-2013
FU Key Prog r a m Special Fund in XJTLU [KSF E-52]
FX This work was fi nancially supported by the Key Prog r a m Special Fund
   in XJTLU (KSF E-52) .
CR Abdou MM, 2020, TETRAHEDRON, V76, DOI 10.1016/j.tet.2020.131251
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NR 37
TC 7
Z9 7
U1 0
U2 9
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 2470-1343
J9 ACS OMEGA
JI ACS Omega
PD JUN 16
PY 2022
VL 7
IS 25
BP 21444
EP 21453
DI 10.1021/acsomega.2c00712
EA JUN 2022
PG 10
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 2R5LJ
UT WOS:000820327500001
PM 35785277
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, YF
   Cai, Z
   Chen, YJ
   Wang, W
   Wang, SB
   Wen, XH
AF Zhang, Yufan
   Cai, Zhen
   Chen, Yongjie
   Wang, Wei
   Wang, Shengbao
   Wen, Xiaohong
TI Salidroside nanoliposomes alleviate postoperative cognitive dysfunction
   by inhibiting Fos-mediated neuroinflammation
SO DISCOVER NEUROSCIENCE
LA English
DT Article
DE Postoperative cognitive dysfunction; Salidroside; Nanoliposomes; Fos;
   Neuroinflammation
AB BackgroundPostoperative cognitive dysfunction (POCD) is a complication that occurs mostly after cardiac, skeletal, and other surgical procedures, commonly present in the elderly. Salidroside (SAL) is an active ingredient extracted from the herb rhodiola rosea that has been verified to protect nerve function and inhibit neuroinflammatory responses.MethodsSAL nanoliposomes (SAL-Nanos) were first prepared, and the apparent morphology was observed by electron microscopy and transmission electron microscopy, followed by evaluation using zeta potential and encapsulation efficiency. POCD mouse models were established using exploratory laparotomy and then subjected to Morris water maze (MWM). Mouse hippocampal tissues were subjected to hematoxylin-eosin (H&E) staining, TdT-mediated dUTP Nick-End Labeling (TUNEL) staining, and enzyme-linked immunosorbent assay (ELISA). Subsequently, mouse hippocampal tissues from each group were taken for transcriptome sequencing, namely differential analysis, trend analysis, and enrichment analysis. Neuroinflammation models were constructed using LPS-induced microglia to observe the effects of SAL and SAL-Nanos on inflammatory factor levels and Fos expression. Changes in inflammatory factor levels and Fos expression were observed by knocking down Fos expression in microglia. Administering Fos inhibitor (T5224), pathological phenotypic changes in POCD mice and Fos expression levels in hippocampal tissues were observed by H&E staining, TUNEL staining, and ELISA.ResultsSAL-Nanos were successfully prepared and could well ameliorate hippocampal inflammation, reduce apoptosis, and protect memory in POCD mice. Transcriptome analysis identified the Toll-like receptor (TLR) signaling pathway and its related molecule Fos to be associated with the improvement of POCD mice by SAL-Nanos. Subsequent studies found that SAL-Nanos can significantly suppress the level of LPS-induced microglia inflammation, improve cell viability, and reduce Fos expression. In addition, Fos knockdown could effectively suppress LPS-induced inflammatory factor levels. It was further demonstrated by in vivo assays that inhibition of Fos expression can significantly alleviate the inflammation level in hippocampal tissues of POCD mice, inhibit apoptosis, and improve memory.ConclusionSAL-Nanos exhibit a more significant therapeutic effect on POCD mice compared to SAL, and its relief effect on POCD mice may inhibit neuroinflammation by down-regulating Fos expression.
C1 [Zhang, Yufan; Cai, Zhen; Wang, Wei] Zhejiang Univ, Affiliated Jinhua Hosp, Sch Med, Dept Anesthesiol, Jinhua, Zhejiang, Peoples R China.
   [Chen, Yongjie] Ningbo Univ, Affiliated Hosp 1, Dept Anaesthesiol, Ningbo, Zhejiang, Peoples R China.
   [Wang, Shengbao] Lanzhou Univ, Hosp 2, Emergency Dept, Lanzhou, Gansu, Peoples R China.
   [Wen, Xiaohong] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Anesthesiol, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
C3 Zhejiang University; Ningbo University; Lanzhou University; Zhejiang
   University
RP Wang, SB (corresponding author), Lanzhou Univ, Hosp 2, Emergency Dept, Lanzhou, Gansu, Peoples R China.; Wen, XH (corresponding author), Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Anesthesiol, 79 Qingchun Rd, Hangzhou 310003, Zhejiang, Peoples R China.
EM Wangshengbao@lzu.edu.cn; 0087420@zju.edu.cn
FU This study was funded by Zhejiang Medical and Health Science and
   Technology Plan Project (No. 2023KY1057).
FX This study was funded by Zhejiang Medical and Health Science and
   Technology Plan Project (No. 2023KY1057) and Gansu Province Traditional
   Chinese Medicine Research Project (No. GZKZ-2024-25).
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NR 33
TC 0
Z9 0
U1 0
U2 0
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 3005-1827
J9 DISCOV NEUROSCI
JI Discov. Neurosci.
PD DEC 4
PY 2025
VL 20
IS 1
AR 26
DI 10.1186/s13064-025-00225-6
PG 15
WC Developmental Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Developmental Biology; Neurosciences & Neurology
GA M5532
UT WOS:001630685700001
OA hybrid
DA 2026-05-27
ER

PT J
AU Qian, CJL
   Wang, SZ
   Chen, HY
AF Qian, Chengjialu
   Wang, Shizhao
   Chen, Hongyan
TI Evaluation study of congelex laxative granules based on HPLC
   fingerprint, multi-component content determination, and chemometrics
SO JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
LA English
DT Article
DE Congelex Laxative Granules; Fingerprint; High performance liquid
   chromatography; Cluster analysis; Principal component analysis;
   Orthogonal partial least squares-discriminant; analysis; Chemometrics
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; PRINCIPAL COMPONENT
AB Congelex Laxative Granules is an in-house preparation of Hebei Provincial Hospital of Traditional Chinese Medicine. This study aims to establish the HPLC fingerprint of Congelex Laxative Granules and evaluate its quality using chemometric methods. The Agilent Eclipse Plus C18 column and a methanol-water gradient elution system were employed, with detection at 224 nm. The High-performance liquid chromatography (HPLC) analysis of 20 batches of samples successfully established a fingerprint with 17 common peaks and a similarity exceeding 0.95. Seven main active components, including salidroside, echinacoside, acteoside, specnuezhenide, wedelolactone, aurantio-obtusin, and chrysophanol, were quantitatively analyzed. Hierarchical Cluster Analysis (HCA), principal component analysis (PCA), and orthogonal partial least squares-discriminant analysis (OPLS-DA) were used to comprehensively evaluate sample quality. Results indicated that the 20 batches could be divided into two categories, with consistent results from PCA and HCA. The OPLS-DA model was stable and reliable, identifying salidroside, acteoside, and chrysophanol as key differential markers. The conclusion shows that the established fingerprint and content determination method provide an accurate and reliable tool for the quality control and comprehensive evaluation of Congelex Laxative Granules.
C1 [Qian, Chengjialu; Wang, Shizhao] Hebei Univ Technol, Sch Chem Engn & Technol, Tianjin 300401, Peoples R China.
   [Chen, Hongyan] Hebei Prov Hosp Tradit Chinese Med, Shijiazhuang 050000, Hebei, Peoples R China.
C3 Hebei University of Technology; Hebei University of Chinese Medicine
RP Chen, HY (corresponding author), Hebei Prov Hosp Tradit Chinese Med, Shijiazhuang 050000, Hebei, Peoples R China.
EM 13011324951@163.com
FU Scientific Research Plan Project of Hebei Administration of Traditional
   Chinese Medicine [2022047, 2023044]; Hebei Provincial Key Research
   Projects [22373101D]; Scientific Research Plan Project of Hebei
   Industrial Technology Institute for Traditional Chinese Medicine
   Preparation [SC2021003]
FX This research was supported by Scientific Research Plan Project of Hebei
   Administration of Traditional Chinese Medicine, Grant/Award Number:
   2022047, 2023044; Hebei Provincial Key Research Projects, Grant/Award
   Number: 22373101D; the Scientific Research Plan Project of Hebei
   Industrial Technology Institute for Traditional Chinese Medicine
   Preparation, Grant/Award Number:SC2021003.
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NR 33
TC 5
Z9 5
U1 9
U2 19
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0731-7085
EI 1873-264X
J9 J PHARMACEUT BIOMED
JI J. Pharm. Biomed. Anal.
PD MAR 15
PY 2025
VL 255
AR 116636
DI 10.1016/j.jpba.2024.116636
EA DEC 2024
PG 8
WC Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Pharmacology & Pharmacy
GA R8P3S
UT WOS:001393995200001
PM 39709682
DA 2026-05-27
ER

PT J
AU Wu, XY
   Liu, C
   Jiang, YQ
   Dai, T
   Zhang, LX
   Wang, JF
   Zhao, HB
AF Wu, Xiaoyu
   Liu, Chun
   Jiang, Yuqing
   Dai, Ting
   Zhang, Linxiang
   Wang, Jiafeng
   Zhao, Hongbin
TI Coaxial Electrospun Polycaprolactone/Gelatin Nanofiber Membrane Loaded
   with Salidroside and Cryptotanshinone Synergistically Promotes
   Vascularization and Osteogenesis
SO INTERNATIONAL JOURNAL OF NANOMEDICINE
LA English
DT Article
DE gelatin; coaxial electrospinning; vascularization and bone regeneration
ID SCAFFOLDS; ANGIOGENESIS; INDUCTION; CELLS
AB Background: Salidroside (SAL) is the most effective component of Rhodiola rosea , a traditional Chinese medicine. Cryptotanshinone (CT) is the main fat-soluble extract of Salvia miltiorrhiza , exhibiting considerable potential for application in osteogenesis. Herein, a polycaprolactone/gelatin nanofiber membrane loaded with CT and SAL (PSGC membrane) was successfully fabricated via coaxial electrospinning and characterized. Methods and Results: This membrane capable of sustained and controlled drug release was employed in this study. Co -culturing the membrane with bone marrow mesenchymal stem cells and human umbilical vein endothelial cells revealed excellent biocompatibility and demonstrated osteogenic and angiogenic capabilities. Furthermore, drug release from the PSGC membrane activated the Wnt/beta-catenin signaling pathway and promoted osteogenic differentiation and vascularization. Evaluation of the membrane's vascularization and osteogenic capacities involved transplantation onto a rat's subcutaneous area and assessing rat cranium defects for bone regeneration, respectively. Microcomputed tomography, histological tests, immunohistochemistry, and immunofluorescence staining confirmed the membrane's outstanding angiogenic capacity two weeks post -operation, with a higher incidence of osteogenesis observed in rat cranial defects eight weeks post -surgery. Conclusion: Overall, the SAL- and CT -loaded coaxial electrospun nanofiber membrane synergistically enhances bone repair and regeneration.
C1 [Wu, Xiaoyu; Dai, Ting; Zhang, Linxiang; Wang, Jiafeng; Zhao, Hongbin] Gansu Prov Cent Hosp, Gansu Prov Matern & Child Care Hosp, Lanzhou 730070, Gansu, Peoples R China.
   [Wu, Xiaoyu; Liu, Chun; Jiang, Yuqing; Dai, Ting; Zhang, Linxiang; Wang, Jiafeng; Zhao, Hongbin] Nanjing Med Univ, Affiliated Changzhou Peoples Hosp 2, Changzhou Med Ctr, Changzhou, Peoples R China.
C3 Nanjing Medical University
RP Zhao, HB (corresponding author), Gansu Prov Cent Hosp, Gansu Prov Matern & Child Care Hosp, Lanzhou 730070, Gansu, Peoples R China.
EM zhao761032@163.com
RI Wu, Xiaoyu/KHY-3972-2024; Wang, Jiafeng/LZE-8700-2025; Zhao,
   Hongbin/A-4166-2019
OI chun, liu/0000-0001-9875-0544; 
FU Clinical Research Project of Changzhou Medical Center of Nanjing Medical
   University [CMCB202206]; Key Project of Science and Technology of
   Jiangsu Province [BE2018644]
FX Acknowledgments This study has been financed by Clinical Research
   Project of Changzhou Medical Center of Nanjing Medical University
   (CMCB202206) , and the Key Project of Science and Technology of Jiangsu
   Province (BE2018644) .
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NR 48
TC 9
Z9 10
U1 5
U2 18
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1178-2013
J9 INT J NANOMED
JI Int. J. Nanomed.
PY 2024
VL 19
DI 10.2147/IJN.S461141
PG 28
WC Nanoscience & Nanotechnology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Pharmacology & Pharmacy
GA WW3J5
UT WOS:001257866100001
PM 38957181
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, F
   Zhang, YM
   Liu, B
   Liu, J
   Lai, BC
   Jia, P
   Zhang, JB
   Ma, Q
   Meng, Y
   Zhao, Y
   Wuren, T
   Zheng, XH
   Tian, HY
   Yin, Q
AF Wang, Fei
   Zhang, Yiman
   Liu, Bing
   Liu, Jia
   Lai, Baochang
   Jia, Pu
   Zhang, Junbo
   Ma, Qiang
   Meng, Yan
   Zhao, Ye
   Wuren, Tana
   Zheng, Xiaohui
   Tian, Hongyan
   Yin, Qian
TI Modulation of HIF1α/CXCR4 by CDDP, acetazolamide, and salidroside in
   early lung injury caused by acute high-altitude hypoxia
SO EUROPEAN JOURNAL OF PHARMACOLOGY
LA English
DT Article
DE High-altitude lung injury; Early inflammation; HIF1 alpha; CXCR4;
   Therapeutic strategies
ID ENDOTHELIAL-CELLS; PULMONARY-HYPERTENSION; CXCR4 EXPRESSION;
   GENE-EXPRESSION; IN-VIVO; CHEMOKINE; INTERMITTENT; INFLAMMATION;
   MECHANISMS; HMGB1
AB Background: The inflammatory response of pulmonary vascular endothelial cells is critical in the pathogenesis of hypobaric hypoxia-induced acute lung injury. Elucidation of the underlying mechanisms and potential therapeutic interventions is crucial for both medical professionals and individuals exposed to high altitudes. Methods: A murine model of acute lung injury was established by subjecting mice to hypobaric hypoxia at an altitude equivalent to 6000 m for 8 and 72 h. Histopathological and immunohistochemical analyses were performed using hematoxylin-eosin staining and immunohistochemistry to assess inflammation. Western blotting for Endothelial Nitric Oxide Synthase (eNOS) phosphorylation was used to evaluate endothelial injury. Highthroughput RNA sequencing was employed to identify early inflammatory regulators, and the protein expression of Hypoxia inducible factor-1 (HIF1 alpha), C-X-C chemokine receptor 4 (CXCR4) and Phospho-Endothelial Nitric Oxide Synthase (p-eNOS) was examined via western blotting. Additionally, the expression level of CXCR4 and selected cytokines were quantified by real-time Polymerase Chain Reaction. Results: Lung tissues demonstrated marked inflammatory infiltration and lung injury after 8 h of hypobaric hypoxia exposure, peaking at 24 h. HIF1 alpha expression was significantly upregulated at 8 h and gradually decreased thereafter. CXCR4, identified as a target gene of HIF1 alpha, exhibited a similar expression pattern. Preventive treatment with compound Danshen dripping pills, acetazolamide and salidroside accelerated the suppression of HIF1 alpha and CXCR4 expression compared to the natural response following 8 h of hypobaric hypoxia. Furthermore, these agents demonstrated enhanced protective effects against endothelial dysfunction and inflammation. Conclusions: These findings indicate that the endothelial HIF1 alpha/CXCR4 axis plays a pivotal role in the early phase of hypobaric hypoxia-induced acute lung injury. The downregulation of HIF1 alpha/CXCR4 by compound Danshen dripping pills, acetazolamide and salidroside suggests promising therapeutic strategies for managing acute highaltitude hypoxic lung injury.
C1 [Wang, Fei; Zhang, Yiman; Liu, Bing; Zhang, Junbo; Ma, Qiang; Meng, Yan; Zheng, Xiaohui; Tian, Hongyan; Yin, Qian] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Peripheral Vasc Dis, Xian 710061, Peoples R China.
   [Wang, Fei; Jia, Pu; Zhao, Ye; Zheng, Xiaohui] Northwest Univ, Coll Life Sci, Shaanxi Prov Ctr Innovat Drug Res, Xian 710069, Peoples R China.
   [Wang, Fei; Zhang, Yiman; Liu, Bing; Liu, Jia; Lai, Baochang; Yin, Qian] Xi An Jiao Tong Univ, Cardiovasc Res Ctr, Sch Basic Med Sci, Xian 710061, Peoples R China.
   [Zhang, Yiman; Yin, Qian] Shaanxi Key Lab Mol Cardiol, Xian 710061, Peoples R China.
   [Liu, Bing; Zhang, Junbo; Ma, Qiang; Meng, Yan; Tian, Hongyan; Yin, Qian] Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Cardiovasc Med, Xian 710061, Peoples R China.
   [Wuren, Tana] Qinghai Univ, Res Ctr High Altitude Med, Sch Med, Key Lab Applicat High Altitude Med, Xining 810016, Peoples R China.
C3 Xi'an Jiaotong University; Northwest University Xi'an; Xi'an Jiaotong
   University; Xi'an Jiaotong University; Qinghai University
RP Zheng, XH; Tian, HY; Yin, Q (corresponding author), Xi An Jiao Tong Univ, Affiliated Hosp 1, Dept Peripheral Vasc Dis, Xian 710061, Peoples R China.
EM zhengxh@nwu.edu.cn; tianhhyyxg@163.com; yinqian610@xjtu.edu.cn
RI Zhang, Junbo/MXK-8769-2025
FU Research and Development Fund of The First Affiliated Hospital of Xi'an
   Jiaotong University [2023GYZX02,2018QN-04]; Basic Scientific Research
   Operating Expenses of Xi'an Jiaotong University [xzy012023131]; Key
   Research and Development Project of Shaanxi Province [2025 GH-YBXM-034];
   Technology Innovation Guidance Project of Shaanxi Provence [2024
   ZC-YYDP-48]; Shaanxi Provincial Center for Innovation Drug Research
   [2022YWZX-01]; Xi'an Key Core Technology Research Project of Key
   Industrial Chain [23LLRH0063]
FX This work was supported by the Research and Development Fund of The
   First Affiliated Hospital of Xi'an Jiaotong University
   (2023GYZX02,2018QN-04) , Basic Scientific Research Operating Expenses of
   Xi'an Jiaotong University (xzy012023131) , Key Research and Development
   Project of Shaanxi Province (NO. 2025 GH-YBXM-034) , Technology
   Innovation Guidance Project of Shaanxi Provence (No. 2024 ZC-YYDP-48) ,
   Shaanxi Provincial Center for Innovation Drug Research (No. 2022YWZX-01)
   , and Xi'an Key Core Technology Research Project of Key Industrial Chain
   (No. 23LLRH0063) .
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PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0014-2999
EI 1879-0712
J9 EUR J PHARMACOL
JI Eur. J. Pharmacol.
PD NOV 5
PY 2025
VL 1006
AR 178174
DI 10.1016/j.ejphar.2025.178174
EA SEP 2025
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 7XO8W
UT WOS:001582050800001
PM 40962012
DA 2026-05-27
ER

PT J
AU Yin, LL
   Ouyang, DY
   Lin, LH
   Xin, XF
   Ji, YH
AF Yin, Lele
   Ouyang, Dongyun
   Lin, Lihong
   Xin, Xiufeng
   Ji, Yuhua
TI Salidroside regulates imbalance of Th17/Treg and promotes ischemic
   tolerance by targeting STAT-3 in cerebral ischemia-reperfusion injury
SO ARCHIVES OF MEDICAL SCIENCE
LA English
DT Article
DE salidroside; STAT-3; middle cerebral artery occlusion; Th17; Treg
AB Introduction: The balance between Th17 and Treg cells controls the immune response and is an important regulator of helper T cells acting on autoimmune diseases. Focal cerebral ischemia-reperfusion injury can induce imbalance of Th17/Treg cells in the brain and the peripheral immune system of rats. The aim of this study was to investigate the effect of salidroside (Sal) on the ratio of Th17 and Treg cells in an adult rat model of middle cerebral artery occlusion (MCAO).
   Material and methods: Forty rats were divided into 4 groups: normal group, sham group, surgery group, and Sal group. After treatment, the neurological deficits in rats were evaluated. Peripheral blood mononuclear cells were isolated and the count of Th17 and Treg cells was detected by flow cytometry. The infarct size and expression of ROR gamma t and Foxp3 were detected in rat brain tissue. Rat spleen cells were isolated, CD4(+) T cells were purified by immunomagnetic beads. Treg cells were induced by adding cytokine TGF-beta. Th17 cells were induced by adding cytokine IL-6. The expression of STAT-3 was inhibited by SiRNA, and the effect of Sal on the differentiation of Th17/Treg cells was analyzed. The expression levels of IL-6, TNF-alpha, MCP-1, STAT-3 and NF-kappa-B2 proteins were examined.
   Results: The results show that MCAO can induce an imbalance of Th17 and Treg cells in peripheral blood of rats. Sal treatment can significantly reduce the neurological deficit and infarct size of MCAO rats, reverse the oxidative stress of rat brain tissue, and inhibit the apoptosis of brain cells in MCAO rats. In the brain tissue of MCAO rats, Sal could significantly inhibit the expression of IL-6, TNF-alpha, MCP-1, STAT-3 and NF-kappa-B2. Down-regulation of STAT-3 significantly reversed the therapeutic effects of Sal treatment.
   Conclusions: Our results indicate that Sal can increase the tolerance of rat brain tissue to ischemia, inhibit cell apoptosis and reduce oxidative stress by targeting STAT-3.
C1 [Yin, Lele; Lin, Lihong] Jinan Univ, Dept Clin Lab, Affiliated Hosp 1, Guangzhou, Peoples R China.
   [Ouyang, Dongyun; Ji, Yuhua] Jinan Univ, Coll Life Sci & Technol, Dept Immunobiol, Guangzhou 510632, Peoples R China.
   [Xin, Xiufeng] Jinan Univ, Dept Neurol, Affiliated Hosp 1, Guangzhou, Peoples R China.
C3 Jinan University; Jinan University; Jinan University
RP Ji, YH (corresponding author), Jinan Univ, Coll Life Sci & Technol, Dept Immunobiol, Guangzhou 510632, Peoples R China.; Yin, LL (corresponding author), Jinan Univ, Dept Clin Lab Ctr, Affiliated Hosp 1, Guangzhou 510630, Peoples R China.
EM leleyin168@163.com; yuhuaji138@163.com
RI Ouyang, Dong-yun/P-7305-2019; Ji, Yuhua/GZL-8978-2022; Ouyang,
   Dong-Yun/P-7305-2019
OI Ouyang, Dong-yun/0000-0002-4743-942X; Ji, Yuhua/0000-0002-6127-7287; 
FU Fundamental Research Funds for the Central Universities [21614311];
   Natural Science Foundation of Guangdong Province, China
   [2015A030310231]; National Natural Science Foundation of China
   [81201016, 81272027]
FX This work was supported by the Fundamental Research Funds for the
   Central Universities (No. 21614311), the Natural Science Foundation of
   Guangdong Province, China (No. 2015A030310231), the National Natural
   Science Foundation of China (No. 81201016 and No. 81272027).
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NR 34
TC 23
Z9 30
U1 1
U2 20
PU TERMEDIA PUBLISHING HOUSE LTD
PI POZNAN
PA KLEEBERGA ST 2, POZNAN, 61-615, POLAND
SN 1734-1922
EI 1896-9151
J9 ARCH MED SCI
JI Arch. Med. Sci.
PD FEB
PY 2021
VL 17
IS 2
BP 523
EP 534
DI 10.5114/aoms.2019.85349
PG 12
WC Medicine, General & Internal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC General & Internal Medicine
GA RH2MN
UT WOS:000636059700026
PM 33747287
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wu, DS
   Dong, Y
   Zhang, DY
   Wang, TT
   Ye, HP
   Zhang, W
AF Wu, Dongsheng
   Dong, Yuang
   Zhang, Dongyang
   Wang, Tongtong
   Ye, Haipeng
   Zhang, Wei
TI Efficacy and safety of dietary polyphenol supplements for COPD: a
   systematic review and meta-analysis
SO FRONTIERS IN IMMUNOLOGY
LA English
DT Article
DE chronic obstructive pulmonary disease; dietary polyphenols;
   meta-analysis; curcumin; salidroside
ID OBSTRUCTIVE PULMONARY-DISEASE; EPITHELIAL-CELLS; DOUBLE-BLIND;
   RESVERATROL; SARCOPENIA; QUERCETIN; CURCUMIN; PREVALENCE; EXPRESSION;
   WOMEN
AB <bold>Background:</bold> The therapeutic application of dietary polyphenols in chronic obstructive pulmonary disease (COPD) management represents an emerging therapeutic paradigm in pulmonary medicine. As bioactive compounds exhibiting dual antioxidant and anti-inflammatory properties, polyphenolic derivatives demonstrate significant therapeutic potential through multimodal mechanisms targeting COPD pathophysiology - particularly in modulating redox homeostasis (GSH/GSSG ratio elevation), attenuating NF-kappa B-mediated inflammatory cascades, and enhancing respiratory function parameters (FEV1 improvement >= 12% from baseline). However, current clinical evidence remains inconclusive, with meta-analyses revealing heterogeneity in intervention outcomes across randomized controlled trials. This systematic investigation employs a triple-blind, placebo-controlled design to rigorously evaluate the clinical efficacy of standardized oral polyphenol supplementation in COPD patients (GOLD stages II-III), incorporating advanced biomarkers including 8-isoprostane quantification and pulmonary function trajectory analysis. <bold>Methods:</bold> Literature on dietary polyphenols for the treatment of COPD published in PubMed, Cochrane, Medline, CNKI and other databases before December 26, 2024 (in Chinese and English) was searched. Manual screening, quality assessment and data extraction of search results were performed in strict accordance with the inclusion and exclusion criteria. Meta-analysis was performed using RevMan 5.3 software. <bold>Results:</bold> The randomized controlled trials (RCTs) included in this review examined dietary supplementation with eight polyphenols-curcumin, resveratrol, anthocyanins, quercetin, salidroside, dietary beetroot juice, pomegranate juice, and adjunctive oral AKL1 treatment-across a total of 894 participants. This systematic review and meta-analysis revealed that, compared to a placebo; (1) Curcumin significantly reduced systolic blood pressure (SBP) and improved FEV1(SMD=-0.82, 95%CI -1.53 to -0.11); (2) Salidroside was effective in reducing thrombotic markers (TT, D-D), inflammatory factors (TNF-alpha) and symptom scores (CAT) (p<0.01); (3) Resveratrol significantly downregulates serum TNF-alpha and IL-8 levels (p=0.003); (4) Anthocyanins may accelerate lung function decline (decreased FEV1/FVC, which needs to be interpreted with caution); (5) Other polyphenols (quercetin, pomegranate juice, AKL1, etc.) did not show significant efficacy or insufficient evidence. It is worth noting that the overall meta-analysis of some indicators (such as FEV1/FVC) did not reach statistical significance, but subgroup analysis suggested the potential value of specific polyphenols. <bold>Conclusion:</bold> This systematic review confirms that the efficacy of dietary polyphenols is significantly composition-specific. Curcumin and salidroside can improve the course of COPD by regulating blood pressure, inflammation, and the coagulation pathway, supporting the hypothesis of "polyphenol targeting of metabolic-inflammatory networks". However, the possible negative effects of anthocyanins warn against ingredient heterogeneity. Clinical significance: Curcumin (200-500 mg/day) and tanshinone are recommended as adjuvant treatment options for COPD, but blind combination should be avoided; the safety of ingredients such as quercetin needs to be further verified.
   These results provide graded evidence for personalized nutritional interventions, promoting the transformation of polyphenol preparations from dietary supplements to precision adjuvant therapies.
C1 [Wu, Dongsheng; Dong, Yuang; Zhang, Dongyang; Wang, Tongtong; Ye, Haipeng] Anhui Univ Tradit Chinese Med, Hefei, Peoples R China.
   [Wu, Dongsheng] Hunan Univ Tradit Chinese Med, Affiliated Hosp 1, Changsha, Peoples R China.
   [Zhang, Wei] Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai, Peoples R China.
C3 Anhui University of Chinese Medicine; Hunan University of Chinese
   Medicine; Shanghai University of Traditional Chinese Medicine
RP Zhang, W (corresponding author), Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Shanghai, Peoples R China.
EM zhangw1190@sina.com
RI zhang, wei/ADK-0893-2022
OI zhang, wei/0000-0003-4816-8390
FU Clinical research and evaluation of TCM diagnosis and treatment of
   sudden acute infectious diseases [ZD2021CY001]; Shanghai Key Laboratory
   of Internal Medicine of Traditional Chinese Medicine [20DZ2272200];
   Zhang Wei Baoshan famous traditional Chinese medicine inheritance studio
   [BSMZYGZS-2024-01]; Zhang Wei Medical Technology Doctor Site
   Construction-Respiratory therapy Technology Direction [A1-N23 204-0405]
FX The author(s) declare that financial support was received for the
   research and/or publication of this article. Clinical research and
   evaluation of TCM diagnosis and treatment of sudden acute infectious
   diseases (grant numbers ZD2021CY001); Shanghai Key Laboratory of
   Internal Medicine of Traditional Chinese Medicine (grant numbers
   20DZ2272200); Zhang Wei Baoshan famous traditional Chinese medicine
   inheritance studio (BSMZYGZS-2024-01); Zhang Wei Medical Technology
   Doctor Site Construction-Respiratory therapy Technology Direction (grant
   numbers A1-N23 204-0405).
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NR 73
TC 3
Z9 3
U1 3
U2 8
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1664-3224
J9 FRONT IMMUNOL
JI Front. Immunol.
PD JUL 23
PY 2025
VL 16
AR 1617694
DI 10.3389/fimmu.2025.1617694
PG 20
WC Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology
GA 5UP2T
UT WOS:001544704800001
PM 40771814
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xing, SS
   Yang, XY
   Li, WJ
   Bian, F
   Wu, D
   Chi, JY
   Xu, G
   Zhang, YH
   Jin, S
AF Xing, Shasha
   Yang, Xiaoyan
   Li, Wenjing
   Bian, Fang
   Wu, Dan
   Chi, Jiangyang
   Xu, Gao
   Zhang, Yonghui
   Jin, Si
TI Salidroside Stimulates Mitochondrial Biogenesis and Protects against
   H2O2-Induced Endothelial Dysfunction
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID NF-KAPPA-B; HYDROGEN-PEROXIDE; NITRIC-OXIDE; OXIDATIVE STRESS; DEPENDENT
   RELAXATION; SMOOTH-MUSCLE; DNA-BINDING; IN-VITRO; ACTIVATION; CELLS
AB Salidroside (SAL) is an active component of Rhodiola rosea with documented antioxidative properties. The purpose of this study is to explore the mechanism of the protective effect of SAL on hydrogen peroxide- (H2O2-) induced endothelial dysfunction. Pretreatment of the human umbilical vein endothelial cells (HUVECs) with SAL significantly reduced the cytotoxicity brought by H2O2. Functional studies on the rat aortas found that SAL rescued the endothelium-dependent relaxation and reduced superoxide anion (O-2 center dot) production induced by H2O2. Meanwhile, SAL pretreatment inhibited H2O2 - induced nitric oxide (NO) production. The underlying mechanisms involve the inhibition of H2O2 - induced activation of endothelial nitric oxide synthase (eNOS), adenosine monophosphate-activated protein kinase (AMPK), and Akt, as well as the redox sensitive transcription factor, NF-kappa B (NF-kappa B). SAL also increased mitochondrial mass and upregulated the mitochondrial biogenesis factors, peroxisome proliferator-activated receptor gamma-coactivator-1alpha (PGC-1 alpha.), and mitochondrial transcription factor A (TFAM) in the endothelial cells. H2O2 - induced mitochondrial dysfunction, as demonstrated by reduced mitochondrial membrane potential (Delta psi m) and ATP production, was rescued by SAL pretreatment. Taken together, these findings implicate that SAL could protect endothelium against H2O2 - induced injury via promoting mitochondrial biogenesis and function, thus preventing the overactivation of oxidative stressrelated downstream signaling pathways.
C1 [Xing, Shasha; Yang, Xiaoyan; Li, Wenjing; Bian, Fang; Wu, Dan; Chi, Jiangyang; Xu, Gao; Zhang, Yonghui; Jin, Si] Huazhong Univ Sci & Technol, Dept Pharmacol, Tongji Med Coll, Wuhan 430030, Peoples R China.
   [Xing, Shasha; Yang, Xiaoyan; Li, Wenjing; Bian, Fang; Wu, Dan; Chi, Jiangyang; Xu, Gao; Zhang, Yonghui; Jin, Si] Key Lab Drug Target Res & Pharmacodynam Evaluat H, Wuhan 430030, Peoples R China.
C3 Huazhong University of Science & Technology
RP Jin, S (corresponding author), Huazhong Univ Sci & Technol, Dept Pharmacol, Tongji Med Coll, Wuhan 430030, Peoples R China.
EM jinsi@mail.hust.edu.cn
RI xing, shasha/JFB-2393-2023; Zhang, Yonghui/AGY-5688-2022; Li,
   Wenjing/JMP-8310-2023; jin, si/KGK-5977-2024
OI jin, si/0000-0003-0727-6715
FU National Natural Science Foundation of China [81373413, 81072634,
   81000080]; Ministry of Education of China [NCET10-0409, 2013YGYL008];
   National Science and Technology Major Projects [2013zx09103-001-020,
   2011zx09102-004-001]
FX This work was supported by Grants from the National Natural Science
   Foundation of China (81373413, 81072634, and 81000080), the Ministry of
   Education of China (NCET10-0409 and 2013YGYL008), and the National
   Science and Technology Major Projects (2013zx09103-001-020 and
   2011zx09102-004-001).
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NR 80
TC 49
Z9 54
U1 1
U2 33
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PY 2014
VL 2014
AR 904834
DI 10.1155/2014/904834
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA AG2MA
UT WOS:000335249400001
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Yang, YH
   Xi, DY
   Wu, YA
   Liu, T
AF Yang, Yihan
   Xi, Daoyi
   Wu, Yanan
   Liu, Tao
TI Complete biosynthesis of the phenylethanoid glycoside verbascoside
SO PLANT COMMUNICATIONS
LA English
DT Article
DE acyltransferase; cytochrome P450; microbial synthesis; verbascoside;
   acteoside; phenylpropanoid
ID PHENYLPROPANOID GLYCOSIDE; ARABIDOPSIS-THALIANA;
   FUNCTIONAL-CHARACTERIZATION; ESCHERICHIA-COLI; ROSMARINIC ACID; BAHD;
   ACYLTRANSFERASE; PURIFICATION; PROTEIN; 3'-HYDROXYLASE
AB Verbascoside, which was first discovered in 1963, is a well-known phenylethanoid glycoside (PhG) that ex-hibits antioxidant, anti-inflammatory, antimicrobial, and neuroprotective activities and contributes to the therapeutic effects of many medicinal plants. However, the biosynthetic pathway of verbascoside remains to be fully elucidated. Here, we report the identification of two missing enzymes in the verbascoside biosyn-thesis pathway by transcriptome mining and in vitro enzymatic assays. Specifically, a BAHD acyltransfer-ase (hydroxycinnamoyl-CoA:salidroside hydroxycinnamoyltransferase [SHCT]) was shown to catalyze the regioselective acylation of salidroside to form osmanthuside A, and a CYP98 hydroxylase (osmanthuside B 3,30-hydroxylase [OBH]) was shown to catalyze meta-hydroxylations of the p-coumaroyl and tyrosol moieties of osmanthuside B to complete the biosynthesis of verbascoside. Because SHCTs and OBHs are found in many Lamiales species that produce verbascoside, this pathway may be general. The findings from the study provide novel insights into the formation of caffeoyl and hydroxytyrosol moieties in natural product biosynthetic pathways. In addition, with the newly acquired enzymes, we achieved heterologous production of osmanthuside B, verbascoside, and ligupurpuroside B in Escherichia coli; this work lays a foundation for sustainable production of verbascoside and other PhGs in micro-organisms.
C1 [Yang, Yihan; Xi, Daoyi; Wu, Yanan; Liu, Tao] Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Key Lab Engn Biol Low Carbon Mfg, Tianjin 300308, Peoples R China.
   [Yang, Yihan; Xi, Daoyi; Wu, Yanan; Liu, Tao] Natl Ctr Technol Innovat Synthet Biol, Tianjin 300308, Peoples R China.
   [Yang, Yihan] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
C3 Chinese Academy of Sciences; Tianjin Institute of Industrial
   Biotechnology, CAS; Chinese Academy of Sciences; University of Chinese
   Academy of Sciences, CAS
RP Liu, T (corresponding author), Chinese Acad Sci, Tianjin Inst Ind Biotechnol, Key Lab Engn Biol Low Carbon Mfg, Tianjin 300308, Peoples R China.; Liu, T (corresponding author), Natl Ctr Technol Innovat Synthet Biol, Tianjin 300308, Peoples R China.
EM liu_t@tib.cas.cn
RI Yang, Yihan/ITR-9611-2023
OI Yang, Yihan/0000-0002-7737-6423
FU National Key Research and Development Program [2019YFA0905703]; National
   Natural Science Foundation of China [31970065, U1902214]; Tianjin
   Synthetic Biotechnology Innovation Capacity Improvement Project
   [TSBICIP-KJGG-002]; Key Research and Development Plan of Guangdong
   Province [2022B1111070005]
FX This work was supported by the National Key Research and Development
   Program (2019YFA0905703) ; the National Natural Science Foundation of
   China (31970065, U1902214) ; the Tianjin Synthetic Biotechnology
   Innovation Capacity Improvement Project (TSBICIP-KJGG-002) ; and the Key
   Research and Development Plan of Guangdong Province (2022B1111070005) .
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NR 63
TC 39
Z9 48
U1 10
U2 127
PU CELL PRESS
PI CAMBRIDGE
PA 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA
SN 2590-3462
J9 PLANT COMMUN
JI Plant Commun.
PD JUL 10
PY 2023
VL 4
IS 4
AR 100592
DI 10.1016/j.xplc.2023.100592
EA JUL 2023
PG 15
WC Biochemistry & Molecular Biology; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Plant Sciences
GA N9WF0
UT WOS:001040421700001
PM 36935606
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lai, ZZ
   Yen, IC
   Hung, HY
   Hong, CY
   Lai, CW
   Lee, YM
AF Lai, Zheng-Zong
   Yen, I-Chuan
   Hung, Hao-Yuan
   Hong, Chen-Yang
   Lai, Chih-Wei
   Lee, Yen-Mei
TI In Vitro Antiviral Activity of Rhodiola crenulata Extract against
   Zika Virus and Japanese Encephalitis Virus: Viral Binding and Stability
SO PHARMACEUTICALS
LA English
DT Article
DE antiviral agent; Rhodiola crenulata; Zika virus; Japanese encephalitis
   virus; salidroside; gallic acid
ID GALLIC ACID; INFECTION; MECHANISMS; ENTRY
AB Zika virus (ZIKV) and Japanese encephalitis virus (JEV) can cause permanent neurological damage and death, yet no approved drugs exist for these infections. Rhodiola crenulate, an herb used in traditional Chinese medicine for its antioxidation and antifatigue properties, was studied for its antiviral activity against ZIKV and JEV in vitro. The cytotoxicity of Rhodiola crenulata extract (RCE) was evaluated using the CCK-8 reagent. Antiviral effects of RCE were assessed in ZIKV-infected or JEV-infected Vero cells via quantitative reverse transcription polymerase chain reaction (qRT-PCR), Western blotting, fluorescent focus assay (FFA), and immunofluorescence assay (IFA). The cell-free antiviral effects of RCE were evaluated using an inactivation assay. To determine the stage of the viral life cycle affected by RCE, time-of-addition, binding, and entry assays were conducted. Three bioactive constituents of RCE (salidroside, tyrosol, and gallic acid) were tested for antiviral activity. RCE exhibited dose-dependent anti-ZIKV and anti-JEV activities at non-cytotoxic concentrations, which were likely achieved by disrupting viral binding and stability. Gallic acid exhibited antiviral activity against ZIKV and JEV. Our findings indicate that RCE disrupts viral binding and stability, presenting a potential strategy to treat ZIKV and JEV infections.
C1 [Lai, Zheng-Zong] Natl Def Med Ctr, Grad Inst Med Sci, Taipei 114, Taiwan.
   [Lai, Zheng-Zong; Hung, Hao-Yuan; Hong, Chen-Yang; Lee, Yen-Mei] Natl Def Med Ctr, Dept & Grad Inst Pharmacol, Taipei 114, Taiwan.
   [Yen, I-Chuan; Lai, Chih-Wei] Natl Def Med Ctr, Sch Pharm, Taipei 114, Taiwan.
C3 National Defense Medical University; National Defense Medical
   University; National Defense Medical University
RP Lee, YM (corresponding author), Natl Def Med Ctr, Dept & Grad Inst Pharmacol, Taipei 114, Taiwan.
EM laizengzong@gmail.com; yenichuan@mail.ndmctsgh.edu.tw;
   hyhung@mail.ndmctsgh.edu.tw; zxc457659@gmail.com;
   penghupharmacy@mail.ndmctsgh.edu.tw; ymlee@mail.ndmctsgh.edu.tw
OI Lai, ZhengZong/0000-0002-4440-3130; Hung, Hao-Yuan/0000-0001-6455-3032;
   洪, 振洋/0009-0002-1383-2001
FU National Defense Medical Center;  [MND-MAB-110-034]; 
   [MND-MAB-D-112078];  [MDN-MAB-C04-113013];  [MND-MAB-D-113145]
FX This research was funded by grants from the National Defense Medical
   Center (MND-MAB-110-034, MND-MAB-D-112078, MDN-MAB-C04-113013, and
   MND-MAB-D-113145) in Taiwan.
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NR 41
TC 3
Z9 3
U1 2
U2 6
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 1424-8247
J9 PHARMACEUTICALS-BASE
JI Pharmaceuticals
PD AUG
PY 2024
VL 17
IS 8
AR 988
DI 10.3390/ph17080988
PG 15
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA F0O5O
UT WOS:001306901500001
PM 39204093
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, ZB
   Teng, X
   Sheng, JZ
AF Zhang Zhao-Bo
   Teng Xiao
   Sheng, Jing-Zhang
TI Anti-inflammatory and anti-apoptotic effect of Rhodiola crenulata
   extract on spinal cord injury in rats
SO TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH
LA English
DT Article
DE Rhodiola crenulata; Haematoxylin-eosin; Caspase-3; Anti-inflammatory;
   Anti-apoptotic
ID ROSEA; SALIDROSIDE; RECOVERY; DAMAGE
AB Purpose: To investigate the effects of Rhodiola crenulata on injured spinal cord tissue recovery due to the presence of neuroprotective constituents such as salidroside, tyrosol, rosavins, and crenulatanoside.
   Methods: Effect of R. crenulata extract (RCE) at doses of 10, 20 and 50 mg kg(-1) was investigated for spinal cord injury (SCI) recovery in rat. The anti-inflammatory activity was estimated by haematoxylineosin (H&E) staining and myeloperoxidase activity assay, while the anti-apoptotic effect was investigated by terminal deoxynucleotidyl transferase dUTP nick-end labelling (TUNEL) and caspase-3 activity assays in SCI tissue.
   Results: RCE (10 mg mL(-1)) treatment resulted in a Basso, Beattie and Bresnahan (BBB) score of 14.50 +/- 1.22, while negative control showed a BBB score of 6.17 +/- 1.60. H&E staining in test groups treated with 20 and 50 mg kg-1 RCE showed statistically different (p < 0.05) histological scores (2.0 +/- 0.37 and 1.83 +/- 0.31, respectively) which are higher than those of SCI (S)-induced group. The estimates of apoptosis in SCI tissue) revealed significant differences from the normalised levels in RCE-treated groups.
   Conclusion: The plant extract produced good recovery of injured spinal tissue, suggesting that further clinical trials and chemical constituent studies are warranted.
C1 [Zhang Zhao-Bo; Teng Xiao; Sheng, Jing-Zhang] Taizhou Cent Hosp, Dept Orthoped, Taizhou 318000, Peoples R China.
C3 Taizhou University
RP Sheng, JZ (corresponding author), Taizhou Cent Hosp, Dept Orthoped, Taizhou 318000, Peoples R China.
EM zhangjingsheng1345@hotmail.com
RI Zhang, Zhaobo/MBV-2092-2025
FU administration of Taizhou Central Hospital, China
FX The authors acknowledge the administration of Taizhou Central Hospital,
   China for providing funds and facilities for the research.
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NR 23
TC 3
Z9 3
U1 2
U2 20
PU PHARMACOTHERAPY GROUP
PI BENIN CITY
PA UNIV BENIN, FACULTY PHARMACY, BENIN CITY, 00000, NIGERIA
SN 1596-5996
J9 TROP J PHARM RES
JI Trop. J. Pharm. Res.
PD MAR
PY 2017
VL 16
IS 3
BP 605
EP 612
DI 10.4314/tjpr.v16i3.15
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA ES0VS
UT WOS:000399247000015
OA gold
DA 2026-05-27
ER

PT J
AU Zhu, HK
   Shen, FL
   Wang, XC
   Cheng, YL
   Guo, YH
   Qian, H
   Liu, Y
AF Zhu, Hongkang
   Shen, Fanglin
   Wang, Xiaochen
   Cheng, Yuliang
   Guo, Yahui
   Qian, He
   Liu, Yu
TI Reshaped Gut Microbial Composition and Functions Associated with the
   Antifatigue Effect of Salidroside in Exercise Mice
SO MOLECULAR NUTRITION & FOOD RESEARCH
LA English
DT Article
DE energy metabolism; fatigue; gut microbiota; muscle injuries; Rhodiola
   rosea; salidroside
ID INDUCED OXIDATIVE STRESS; RHODIOLA-CRENULATA; FATIGUE; PERFORMANCE;
   MODULATION; MACA
AB ScopeSalidroside (SA) is an active compound derived from Rhodiola rosea and is widely used in healthcare foods. However, the underlying mechanism and its specific role in regulating the gut microbial community during exercise (Ex) remains unknown. Methods and resultsMice are subjected to a weight-loaded swimming test (WST) Ex to determine how gut microbiota affects the antifatigue activity of SA. The SA-treated group mice (100 mg kg(-1).bw.) display a significant increase in swimming time compared to the control group (26.2 versus 10.5 min, p < 0.01), as well as an increase in respiratory enzymatic activities after swimming. The respiratory enzymatic activities are significantly higher in the SA-treated group than in the RS (regular rest) group after swimming. The bacteria profiles in the Ex + SA group change significantly with higher species diversity and abundance. Receiver operating characteristic (ROC) curves of Alistipes, Rikenellaceae, Parabacteroides, Candidatus Arthromitus, and Lactobacillus indicate a high diagnostic utility to distinguish SA treatment. Microbial function analysis shows that SA may improve Ex-induced fatigue by modulating energy metabolism-related processes. ConclusionsSA demonstrates antifatigue effects on various levels of regulating energy metabolism and microbial composition, providing insights into the underlying mechanisms of SA as a natural prebiotic.
C1 [Zhu, Hongkang; Cheng, Yuliang; Guo, Yahui; Qian, He] Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.
   [Zhu, Hongkang; Cheng, Yuliang; Guo, Yahui; Qian, He] Jiangnan Univ, Collaborat Innovat Ctr Food Safety & Qual Control, Wuxi 214122, Jiangsu, Peoples R China.
   [Zhu, Hongkang; Cheng, Yuliang; Guo, Yahui; Qian, He] Jiangnan Univ, Sch Food Sci & Technol, 1800 Lihu Ave, Wuxi 214122, Jiangsu, Peoples R China.
   [Shen, Fanglin] Wuxi Univ, Wuxi 214126, Jiangsu, Peoples R China.
   [Wang, Xiaochen; Liu, Yu] Soochow Univ, Wuxi Peoples Hosp Affiliated 9, Wuxi 214062, Jiangsu, Peoples R China.
C3 Jiangnan University; Jiangnan University; Jiangnan University; Wuxi
   University; Soochow University - China
RP Qian, H (corresponding author), Jiangnan Univ, State Key Lab Food Sci & Technol, Wuxi 214122, Jiangsu, Peoples R China.; Qian, H (corresponding author), Jiangnan Univ, Collaborat Innovat Ctr Food Safety & Qual Control, Wuxi 214122, Jiangsu, Peoples R China.; Qian, H (corresponding author), Jiangnan Univ, Sch Food Sci & Technol, 1800 Lihu Ave, Wuxi 214122, Jiangsu, Peoples R China.; Liu, Y (corresponding author), Soochow Univ, Wuxi Peoples Hosp Affiliated 9, Wuxi 214062, Jiangsu, Peoples R China.
EM qianhe@jiangnan.edu.cn; liuyu2956@suda.edu.cn
RI Guo, Yahui/ABE-2248-2020
OI Guo, Yahui/0000-0002-6512-355X; Zhu, Hongkang/0000-0003-4734-556X
FU Youth talent project of Wuxi health commission [Q202150]; Duo-Innovative
   and Excellent Doctors Project of Wuxi 9th People's Hospital [YB202107]
FX This work is financially supported by the Youth talent project of Wuxi
   health commission (Q202150), and Duo-Innovative and Excellent Doctors
   Project of Wuxi 9th People's Hospital (YB202107). The authors sincerely
   thank Chengrui Wang (engineer, Shenzhen Weikemeng Technology Group Co.,
   Ltd., China) for the instruction of 16s rRNA analysis.
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NR 56
TC 16
Z9 16
U1 3
U2 47
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1613-4125
EI 1613-4133
J9 MOL NUTR FOOD RES
JI Mol. Nutr. Food Res.
PD JUN
PY 2023
VL 67
IS 12
DI 10.1002/mnfr.202300015
EA MAY 2023
PG 11
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA J9RU2
UT WOS:000979779300001
PM 37082899
OA Bronze
DA 2026-05-27
ER

PT J
AU Li, R
   Guo, YJ
   Zhang, YM
   Zhang, X
   Zhu, LP
   Yan, TH
AF Li, Rui
   Guo, Yujuan
   Zhang, Yiming
   Zhang, Xue
   Zhu, Lingpeng
   Yan, Tianhua
TI Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the
   TLR4/NF-B and MAPK Signaling Pathways
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE salidroside; renal interstitial fibrosis; epithelial-mesenchymal
   transition; TLR4; inflammation
ID OBSTRUCTIVE NEPHROPATHY; URETERAL OBSTRUCTION; INFLAMMATION; ACTIVATION;
   CELLS; MODEL; RECEPTORS; CYTOKINES; INJURY; MICE
AB Salidroside (Sal) is an active ingredient that is isolated from Rhodiola rosea, which has been reported to have anti-inflammatory activities and a renal protective effect. However, the role of Sal on renal fibrosis has not yet been elucidated. Here, the purpose of the current study is to test the protective effects of Sal against renal interstitial fibrosis (RIF), and to explore the underlying mechanisms using both in vivo and in vitro models. In this study, we establish the unilateral ureteric obstruction (UUO) or folic acid (FA)-induced mice renal interstitial fibrosis in vivo and the transforming growth factor (TGF)-1-stimulated human proximal tubular epithelial cell (HK-2) model in vitro. The levels of kidney functional parameters and inflammatory cytokines in serum are examined. The degree of renal damage and fibrosis is determined by histological assessment. Immunohistochemistry and western blotting are used to determine the mechanisms of Sal against RIF. Our results show that treatment with Sal can ameliorate tubular injury and deposition of the extracellular matrix (ECM) components (including collagen ? and collagen I). Furthermore, Sal administration significantly suppresses epithelial-mesenchymal transition (EMT), as evidenced by a decreased expression of -SMA, vimentin, TGF-1, snail, slug, and a largely restored expression of E-cadherin. Additionally, Sal also reduces the levels of serum biochemical markers (serum creatinine, Scr; blood urea nitrogen, BUN; and uric acid, UA) and decreases the release of inflammatory cytokines (IL-1, IL-6, TNF-). Further study revealed that the effect of Sal on renal interstitial fibrosis is associated with the lower expression of TLR4, p-IB, p-NF-B and mitogen-activated protein kinases (MAPK), both in vivo and in vitro. In conclusion, Sal treatment improves kidney function, ameliorates the deposition of the ECM components and relieves the protein levels of EMT markers in mouse kidneys and HK-2 cells. Furthermore, Sal treatment significantly decreases the release of inflammatory cytokines and inhibits the TLR4/NF-B and MAPK signaling pathways. Collectively, these results suggest that the administration of Sal could be a novel therapeutic strategy in treating renal fibrosis.
C1 [Li, Rui; Guo, Yujuan; Zhang, Yiming; Zhang, Xue; Yan, Tianhua] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Dept Physiol & Pharmacol, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China.
   [Zhu, Lingpeng] China Pharmaceut Univ, Sch Life Sci & Technol, Dept Biochem, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Dept Physiol & Pharmacol, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China.; Zhu, LP (corresponding author), China Pharmaceut Univ, Sch Life Sci & Technol, Dept Biochem, 24 Tongjiaxiang, Nanjing 210009, Jiangsu, Peoples R China.
EM lr082261@163.com; yujuanguo@vip.163.com; 15298360632@163.com;
   abc18851107671@163.com; zhulingpeng2008@126.com;
   tianhuayan0822edu@163.com
RI Su, Tianyuan/Y-7054-2019
OI Yan, Tianhua/0000-0001-6124-8630; Li, Rui/0000-0002-2511-9409; Zhu,
   Lingpeng/0000-0003-0762-4038
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NR 45
TC 179
Z9 219
U1 0
U2 24
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR 1
PY 2019
VL 20
IS 5
AR 1103
DI 10.3390/ijms20051103
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HQ6QE
UT WOS:000462542300102
PM 30836660
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Marchev, AS
   Dimitrova, P
   Koycheva, IK
   Georgiev, MI
AF Marchev, Andrey S.
   Dimitrova, Petya
   Koycheva, Ivanka K.
   Georgiev, Milen I.
TI Altered expression of TRAIL on mouse T cells via ERR phosphorylation by
   Rhodiola rosea L. and its marker compounds
SO FOOD AND CHEMICAL TOXICOLOGY
LA English
DT Article; Proceedings Paper
CT 2nd International Symposium on Phytochemicals in Medicine and Food
   (ISPMF)
CY APR 07-10, 2017
CL Fuzhou, PEOPLES R CHINA
SP Phytochem Soc Europe, Phytochem Soc Asia, Int Soc Chinese Med, Fujian Agr & Forestry Univ, Univ Macau, Univ Hong Kong, Kunming Univ Sci & Technol, Yancheng Inst Technol, Guiyang Med Univ, Nanchang Univ, Hebei Normal Univ Sci & Technol, Zhejiang Univ, Beijing Normal Univ, Jinan Univ
DE Golden root; Rosavins; T cells; TRAIL; ERK; 2D NMR
ID KAPPA-B; SALIDROSIDE; APOPTOSIS; ACTIVATION; DISCOVERY; RESPONSES;
   EXTRACT; INHIBITORS; NECROSIS; GROWTH
AB Rhodiola rosea L. extracts have shown neuroprotective, anti-fatigue, anti-inflammatory and anti-tumor properties. However, the studies on their effect on T cell function are rather scarce. We examined the potential of R. rosea extract and its major constituents - salidroside, rosarin, rosavin and rosin to alter cell growth of human Jurkat T cells, apoptosis of splenic mouse CD3 T cells and expression of the surface markers and phosphorylation of extracellular signal-regulated kinase (ERK). The initial screening for cell viability in Jurkat T cells and for apoptosis of mouse T cells showed the strongest activity for rosavin and rosarin. Rosarin and rosavin did not alter significantly the dynamic of CD69 expression upon stimulation, but altered TNF-related apoptosis-inducing ligand (TRAIL) expression. Rosavin inhibited TRAIL up regulation, while rosarin showed an opposite effect. Indeed, rosarin increased the frequencies of CD3(+)TRAIL(+) T cells and the fold inhibition of ERK phosphorylation. Our data showed that different effects of rosarin and rosavin on TRAIL expression can involve distinct action on ERK signaling and hence highlighted their potential to manipulate TRAIL as a tool to rescue the resistance to apoptosis in auto immune diseases and cancer. (C) 2017 Elsevier Ltd. All rights reserved.
C1 [Marchev, Andrey S.; Koycheva, Ivanka K.; Georgiev, Milen I.] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Grp Plant Cell Biotechnol & Metabol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria.
   [Dimitrova, Petya] Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Dept Immunol, 26 Georgi Bonchev Str, Sofia 1113, Bulgaria.
C3 Bulgarian Academy of Sciences; Stephan Angeloff Institute of
   Microbiology, Bulgarian Academy of Sciences; Bulgarian Academy of
   Sciences; Stephan Angeloff Institute of Microbiology, Bulgarian Academy
   of Sciences
RP Marchev, AS; Georgiev, MI (corresponding author), Bulgarian Acad Sci, Stephan Angeloff Inst Microbiol, Grp Plant Cell Biotechnol & Metabol, 139 Ruski Blvd, Plovdiv 4000, Bulgaria.
EM andrey.marchev@yahoo.com; milengeorgiev@gbg.bg
RI ; Dimitrova, Petya/AFW-8031-2022; Georgiev, Milen I/P-6948-2015;
   Marchev, Andrey/PFR-2450-2026
OI Marchev, Aney/0000-0002-7660-683X; Koycheva, Ivanka/0000-0002-0785-2308;
   Dimitrova, Petya/0000-0003-0920-3712; Georgiev, Milen
   I/0000-0001-5248-6135; 
FU Program for career development of young scientists, Bulgarian Academy of
   Sciences [DFNP-58]
FX This study was supported by Program for career development of young
   scientists, Bulgarian Academy of Sciences, Project number DFNP-58.
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NR 56
TC 20
Z9 24
U1 0
U2 15
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0278-6915
EI 1873-6351
J9 FOOD CHEM TOXICOL
JI Food Chem. Toxicol.
PD OCT
PY 2017
VL 108
SI SI
BP 419
EP 428
DI 10.1016/j.fct.2017.02.009
PN B
PG 10
WC Food Science & Technology; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED); Conference Proceedings Citation Index - Science (CPCI-S)
SC Food Science & Technology; Toxicology
GA FJ9XP
UT WOS:000413135100007
PM 28189478
DA 2026-05-27
ER

PT J
AU Kang, X
   Wang, GW
   Zhang, Q
   Shen, KC
   Gu, T
   Yang, TT
   Zhang, JM
   Ma, XN
   Yang, NA
   Liu, B
   Wang, ZH
AF Kang, Xue
   Wang, Guowei
   Zhang, Qi
   Shen, Kaichun
   Gu, Tao
   Yang, Tingting
   Zhang, Jiamei
   Ma, Xiaona
   Yang, Ningai
   Liu, Bin
   Wang, Zhenhai
TI Amelioration of experimental autoimmune neuritis by reprogramming M1
   macrophages and direct remyelination using targeted nanoparticles
SO CHEMICAL ENGINEERING JOURNAL
LA English
DT Article
DE Experimental autoimmune neuritis; Cytosporone B; Salidroside; Macrophage
   reprogramming; Targeted delivery; Liposome nanoparticles
ID NUR77
AB Guillain-Barre<acute accent> syndrome (GBS), an autoimmune neuropathy characterized by immune dysregulation and demyelination, presents challenges for single-target immunotherapies due to its complex pathogenesis. To address this challenge, a dual-functional CD44-targeted biomimetic nanoparticle system, HA-M@Lipo@ (CSNB+SAL) NPs, was developed to integrate immunomodulation and neuroregeneration. The nanosystem codelivers Cytosporone B (CSNB), an NR4A1 agonist, and salidroside (SAL), a neurotrophic agent. In vitro, the nanoparticles exhibited 2.97-fold and 1.31-fold higher targeting efficiency toward LPS-stimulated RAW264.7 cells and H2O2-stimulated RSC96 cells, respectively, compared to Lipo@(CSNB+SAL) NPs. This enhanced targeting facilitated M1-to-M2 macrophage repolarization and directly promoted RSC96 cell migration and proliferation. In an experimental autoimmune neuritis (EAN) rat model, treatment with HA-M@Lipo@(CSNB+SAL) NPs markedly reduced inflammatory macrophage infiltration, suppressed pro-inflammatory cytokines (IL-1 beta and TNF-alpha), and accelerated sciatic nerve repair. Mechanistic investigations revealed that the nanoparticles reprogrammed macrophage metabolism by suppressing glycolysis and enhancing oxidative phosphorylation (OXPHOS) via the NR4A1/HIF-1 alpha/HK2 axis. These findings highlight HA-M@Lipo@(CSNB+SAL) NPs as a promising therapeutic platform for GBS, enabling synergistic regulation of immune homeostasis and neuroregeneration through targeted dual-drug delivery.
C1 [Kang, Xue; Shen, Kaichun; Gu, Tao] Ningxia Med Univ, Sch Clin Med, Yinchuan 750004, Peoples R China.
   [Kang, Xue] Air Force Mil Med Univ, Tangdu Hosp, Dept Neurol, Xian 710038, Shaanxi, Peoples R China.
   [Wang, Guowei] Chongqing Med Univ, Dept Neurol, NHC Key Lab Diag & Treatment Brain Funct Dis, Affiliated Hosp 1, Chongqing 400016, Peoples R China.
   [Zhang, Qi] Ningxia Med Univ, Coll Lab Med, Yinchuan 750004, Peoples R China.
   [Yang, Tingting; Zhang, Jiamei; Ma, Xiaona; Yang, Ningai; Wang, Zhenhai] Gen Hosp Ningxia Med Univ, Inst Med Sci, Yinchuan 750004, Peoples R China.
   [Yang, Tingting; Zhang, Jiamei; Ma, Xiaona; Yang, Ningai; Wang, Zhenhai] Diag & Treatment Engn Technol Res Ctr Nervous Syst, Yinchuan 750004, Peoples R China.
   [Liu, Bin] Hunan Univ, Coll Biol, Changsha 410082, Peoples R China.
   [Wang, Zhenhai] Gen Hosp Ningxia Med Univ, Neurol Ctr, Gen Hosp, Yinchuan 750004, Peoples R China.
C3 Ningxia Medical University; Air Force Medical University; Chongqing
   Medical University; Ningxia Medical University; Ningxia Medical
   University; Hunan University; Ningxia Medical University
RP Wang, ZH (corresponding author), Gen Hosp Ningxia Med Univ, Inst Med Sci, Yinchuan 750004, Peoples R China.; Wang, ZH (corresponding author), Diag & Treatment Engn Technol Res Ctr Nervous Syst, Yinchuan 750004, Peoples R China.; Liu, B (corresponding author), Hunan Univ, Coll Biol, Changsha 410082, Peoples R China.; Wang, ZH (corresponding author), Gen Hosp Ningxia Med Univ, Neurol Ctr, Gen Hosp, Yinchuan 750004, Peoples R China.
EM binliu2001@hotmail.com; nyfywzh@163.com
RI Wang, Guowei/MGA-9080-2025
FU National Nature Science of China [82371358]; Science and Technology Key
   Research Program of Ningxia Hui Autonomous Region [2023BEG02073]
FX This work was supported by the National Nature Science of China (grant
   number 82371358) and the Science and Technology Key Research Program of
   Ningxia Hui Autonomous Region (grant number 2023BEG02073) .
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NR 61
TC 0
Z9 0
U1 5
U2 16
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 1385-8947
EI 1873-3212
J9 CHEM ENG J
JI Chem. Eng. J.
PD OCT 15
PY 2025
VL 522
AR 167697
DI 10.1016/j.cej.2025.167697
EA SEP 2025
PG 17
WC Engineering, Environmental; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA 7EF6G
UT WOS:001568928500011
OA hybrid
DA 2026-05-27
ER

PT J
AU Guney, T
   Kohles, SA
   Thompson, VL
   Phillips, GJ
   Kraus, GA
AF Guney, Tezcan
   Kohles, Stephanie A.
   Thompson, Victoria L.
   Phillips, Gregory J.
   Kraus, George A.
TI Heterocycles from wine: synthesis and biological evaluation of
   salidrosides
SO TETRAHEDRON
LA English
DT Article
DE Wine polyphenols; Tannins; Salidroside; Galloyl-substituted
   salidrosides; Antimicrobial activity
ID QUERCUS-STENOPHYLLA MAKINO; IN-VIVO; ELLAGITANNINS; RESVERATROL;
   TANNINS; POLYPHENOLS; CHEMISTRY; OXIDATION; ANALOGS
AB Wine is composed of a variety of tannins, of which a sub-class includes salidrosides, which are largely uninvestigated compounds. The first syntheses of galloylated salidrosides are reported in 7 steps from commercially available starting materials through a platform approach. The antimicrobial activity of the salidrosides against Escherichia coli strains is described. (C) 2014 Elsevier Ltd. All rights reserved.
C1 [Guney, Tezcan; Kraus, George A.] Iowa State Univ, Dept Chem, Ames, IA 50011 USA.
   [Kohles, Stephanie A.; Thompson, Victoria L.; Phillips, Gregory J.] Iowa State Univ, Dept Vet Microbiol, Ames, IA 50011 USA.
C3 Iowa State University; Iowa State University
RP Kraus, GA (corresponding author), Iowa State Univ, Dept Chem, Ames, IA 50011 USA.
EM gakraus@iastate.edu
OI Guney, Tezcan/0000-0002-4587-6773
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NR 25
TC 7
Z9 7
U1 1
U2 25
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0040-4020
J9 TETRAHEDRON
JI Tetrahedron
PD MAY 20
PY 2015
VL 71
IS 20
BP 3115
EP 3119
DI 10.1016/j.tet.2014.08.065
PG 5
WC Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC); Current Chemical Reactions (CCR-EXPANDED)
SC Chemistry
GA CH6LF
UT WOS:000354147400021
DA 2026-05-27
ER

PT J
AU Xie, ZP
   Lu, H
   Yang, SX
   Zeng, Y
   Li, W
   Wang, LL
   Luo, GF
   Fang, F
   Zeng, T
   Cheng, WD
AF Xie, Zeping
   Lu, Hui
   Yang, Sixia
   Zeng, Yi
   Li, Wei
   Wang, Linlin
   Luo, Guanfeng
   Fang, Fang
   Zeng, Ting
   Cheng, Weidong
TI Salidroside Attenuates Cognitive Dysfunction in Senescence-Accelerated
   Mouse Prone 8 (SAMP8) Mice and Modulates Inflammation of the Gut-Brain
   Axis
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE microbiota; inflammation; microglia; SAMP8; cognition; salidroside
ID ALZHEIMERS-DISEASE; AMYLOID-BETA; MICROBIOTA; MICROGLIA; MODEL; IMPACT
AB Background: Alzheimer's disease (AD) is a fatal neurodegenerative disease characterized by progressive cognitive decline and memory loss. However, several therapeutic approaches have shown unsatisfactory outcomes in the clinical setting. Thus, developing alternative therapies for the prevention and treatment of AD is critical. Salidroside (SAL) is critical, an herb-derived phenylpropanoid glycoside compound, has been shown to attenuate lipopolysaccharide (LPS)-induced cognitive impairment. However, the mechanism underlying its neuroprotective effects remains unclear. Here, we show that SAL has a therapeutic effect in the senescence-accelerated mouse prone 8 (SAMP8) strain, a reliable and stable mouse model of AD.
   Methods: SAMP8 mice were treated with SAL, donepezil (DNP) or saline, and cognitive behavioral impairments were assessed using the Morris water maze (MWM), Y maze, and open field test (OFT). Fecal samples were collected and analyzed by 16S rRNA sequencing on an Illumina MiSeq system. Brain samples were analyzed to detect beta-amyloid (A beta) 1-42 (A beta 1-42) deposition by immunohistochemistry (IHC) and western blotting. The activation of microglia and neuroinflammatory cytokines was detected by immunofluorescence (IF), western blotting and qPCR. Serum was analyzed by a Mouse High Sensitivity T Cell Magnetic Bead Panel on a Luminex-MAGPIX multiplex immunoassay system.
   Results: Our results suggest that SAL effectively alleviated hippocampus-dependent memory impairment in the SAMP8 mice. SAL significantly 1) reduced toxic A beta 1-42 deposition; 2) reduced microglial activation and attenuated the levels of the proinflammatory factors IL-1 beta, IL-6, and TNF-alpha in the brain; 3) improved the gut barrier integrity and modified the gut microbiota (reversed the ratio of Bacteroidetes to Firmicutes and eliminated Clostridiales and Streptococcaceae, which may be associated with cognitive deficits); and 4) decreased the levels of proinflammatory cytokines, particularly IL-1 alpha, IL-6, IL-17A and IL-12, in the peripheral circulation, as determined by a multiplex immunoassay.
   Conclusion: In summary, SAL reversed AD-related changes in SAMP8 mice, potentially by regulating the microbiota-gut-brain axis and modulating inflammation in both the peripheral circulation and central nervous system. Our results strongly suggest that SAL has a preventive effect on cognition-related changes in SAMP8 mice and highlight its value as a potential agent for drug development.
C1 [Xie, Zeping; Yang, Sixia; Fang, Fang] Southern Med Univ, Sch Tradit Chinese Med, Tradit Chinese Pharmacol Lab, Guangzhou, Peoples R China.
   [Lu, Hui; Zeng, Yi; Wang, Linlin; Luo, Guanfeng; Zeng, Ting; Cheng, Weidong] Southern Med Univ, Sch Tradit Chinese Med, Guangzhou, Peoples R China.
   [Li, Wei] Shanghai Univ Tradit Chinese Med, Inst Chinese Mat Med, Shanghai, Peoples R China.
C3 Southern Medical University - China; Southern Medical University -
   China; Shanghai University of Traditional Chinese Medicine
RP Cheng, WD (corresponding author), Southern Med Univ, Sch Tradit Chinese Med, Guangzhou, Peoples R China.
EM chengweidong888@sina.com
RI Cheng, Weidong/LMP-6222-2024; hui, lu/AAE-4143-2022
OI Xie, Zeping/0000-0002-3120-5565; hui, lu/0000-0002-2656-2103
FU Guangzhou Municipal Science and Technology Project [201904010168];
   National Natural Science Foundation of China [81973641]; National Key
   Research and Development Program of China [2018YFC1704400]
FX This research was funded by the Guangzhou Municipal Science and
   Technology Project (grant number 201904010168), the National Natural
   Science Foundation of China (grant number 81973641), and the National
   Key Research and Development Program of China (grant number
   2018YFC1704400).
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NR 52
TC 76
Z9 89
U1 5
U2 60
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD DEC 9
PY 2020
VL 11
AR 568423
DI 10.3389/fphar.2020.568423
PG 13
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA PJ2FS
UT WOS:000601591200001
PM 33362539
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Yuan, L
AF Yuan, Ling
TI Salidroside Combats Aging and Cancers through Oxidative Stress
   Mitigation
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
ID RHODIOLA-ROSEA L.; SKELETAL-MUSCLE; CELL-CYCLE; IN-VITRO; MIGRATION;
   PATHWAY; GROWTH; ACTIVATION; INHIBITION; PROLIFERATION
AB Salidroside (Sal) is the primary active constituent of the Rhodiola genus, which is usually processed into precious medicinal herbs and functional foods. Sal has emerged as a focal point in therapeutics against aging and cancer including the highly malignant pancreatic ductal adenocarcinoma, due to its multi-target biological activities. This review systematically summarizes the chemical properties of Sal, its pharmacological effects on cellular targets and signaling pathways, and the mechanisms underlying its anti-aging and anti-cancer effects. The molecular structure of Sal, characterized by glycosidic bonds and hydroxyl groups, provides it with antioxidant activity and the ability to interact with multiple proteins. By reducing the cellular levels of reactive oxygen species (ROS), Sal modulates several signaling axes related to human wellness, including Nrf2, SIRT1/2, PI3K/AKT, JAK2/STAT3, and other pathways. As a result, Sal exerts its anti-aging effects through alleviating oxidative stress, preventing cellular senescence, and improving cardiovascular function, while its anti-cancer activities are driven by inhibiting cell proliferation/survival, migration/ metastasis, and modulating the tumor microenvironment/immunity. This review may contribute to a deeper understanding of Sal's biological activities and facilitate its transition from laboratory discoveries to clinical applications in aging and cancer management.
C1 [Yuan, Ling] Chongqing Hosp Tradit Chinese Med, Chongqing, Peoples R China.
RP Yuan, L (corresponding author), Chongqing Hosp Tradit Chinese Med, Chongqing, Peoples R China.
EM 15736204002@163.com
FU Chongqing Natural Science Foundation [cstc2021jcyj-msxmX1022]
FX This work was financially supported by the Chongqing Natural Science
   Foundation (cstc2021jcyj-msxmX1022) .
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U1 1
U2 1
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD DEC
PY 2025
IS 226
AR e69735
DI 10.3791/69735
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA AX4BX
UT WOS:001659036900002
PM 41428598
DA 2026-05-27
ER

PT J
AU Li, RR
   Chen, JZ
AF Li, Ruru
   Chen, Jianzong
TI Salidroside Protects Dopaminergic Neurons by Enhancing
   PINK1/Parkin-Mediated Mitophagy
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID ALPHA-SYNUCLEIN; MITOCHONDRIAL; MECHANISMS; AUTOPHAGY; PARIS
AB Parkinson's disease (PD) is a common neurodegenerative disease characterized by the degeneration of nigrostriatal dopaminergic (DA) neurons. Our previous studies have suggested that salidroside (Sal) might play neuroprotective effects against PD by preserving mitochondrial Complex I activity. However, the exact mechanism of the neuroprotective effect of Sal remains unclear. Growing evidence indicates that PINK1/Parkin-mediated mitophagy is involved in the development of PD. In this study, we investigated whether Sal exerts a neuroprotective effect by modulating PINK1/Parkin-mediated mitophagy. Results showed that Sal alleviated MPTP-induced motor deficits in pole test. Moreover, Sal diminished MPTP-induced degeneration of nigrostriatal DA neurons as evidenced by upregulated TH-positive neurons in the substantia nigra, increased DAT expression, and high dopamine and metabolite levels in the striatum. Furthermore, in comparison with the MPP+/MPTP group, Sal considerably increased the mitophagosome and mitophagy flux. Moreover, in comparison with the MPP+/MPTP group, Sal evidently enhanced the mitochondrial expression of PINK1 and Parkin, accompanied by an increase in the colocalization of mitochondria with Parkin. However, transfection of MN9D cells with PINK1 siRNA reversed Sal-induced activated mitophagy and cytoprotective effect. In conclusion, Sal may confer neuroprotective effects by enhancing PINK1/Parkin-mediated mitophagy in MPP+/MPTP-induced PD models.
C1 [Li, Ruru] Air Force Hosp Southern Theater Command, Dept Neurol, Guangzhou 510062, Guangdong, Peoples R China.
   [Li, Ruru; Chen, Jianzong] Fourth Mil Med Univ, Xijing Hosp, Dept Chinese Med, Xian 710032, Shaanxi, Peoples R China.
C3 Air Force Medical University
RP Chen, JZ (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Dept Chinese Med, Xian 710032, Shaanxi, Peoples R China.
EM jzchen57@fmmu.edu.cn
OI Li, Ruru/0000-0002-2927-7682
FU National Nature Science Foundation of China [81173590]
FX This work was supported by the National Nature Science Foundation of
   China (Grant number 81173590).
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NR 38
TC 59
Z9 67
U1 3
U2 34
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD SEP 10
PY 2019
VL 2019
AR 9341018
DI 10.1155/2019/9341018
PG 11
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA JA4PF
UT WOS:000487810900010
PM 31583052
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Guo, BY
   Zuo, ZF
   Di, XW
   Huang, Y
   Gong, G
   Xu, B
   Wang, LL
   Zhang, XY
   Liang, Z
   Hou, Y
   Liu, XZ
   Hu, ZS
AF Guo, Baoyue
   Zuo, Zhongfu
   Di, Xingwei
   Huang, Ying
   Gong, Gu
   Xu, Bo
   Wang, Lulu
   Zhang, Xiaoyu
   Liang, Zhuang
   Hou, Yang
   Liu, Xuezheng
   Hu, Zhansheng
TI Salidroside attenuates HALI via IL-17A-mediated ferroptosis of alveolar
   epithelial cells by regulating Act1-TRAF6-p38 MAPK pathway
SO CELL COMMUNICATION AND SIGNALING
LA English
DT Article
DE IL-17A; Ferroptosis; Salidroside; Immune cells; HALI
ID ACUTE LUNG INJURY
AB Background and Purpose: Hyperoxia-induced acute lung injury (HALI) is a critical life-threatening disorder characterized by severe infiltration immune cells and death of type II alveolar epithelial cells (AECII). However, little is known about the relations between immune cells and AECII in HALI. IL-17A is a pro-inflammatory cytokine mainly secreted by Th17 cells, contributing to the pathogenesis of various inflammatory diseases. The present study investigated the role of IL-17A in cell-cell communication between immune cells and AECII in HALT, and explored the therapeutic effect of salidroside (Sal, a natural anti-inflammatory agents) on HALI.
   Methods: Mice with HALI were induced by exposure to hyperoxia over 90% for 12 h, 24 h, 48 h or 72 h, and the optimal timing was detected by H&E and Masson staining. Ferroptosis was confirmed by detecting the levels of MDA, Fe2+ and GPX4, and the morphological alterations of AECII under transmission electron microscopy. The expression of pro-inflammatory cytokine, including IL-6, TGF-beta 1, IL-17A and IL-17A receptor (IL-17RA) were measured by Western blotting and immunohistochemical stanning. The ferroptosis-related Act1/TRAF6/p38 MAPK pathway was detected by Western blotting. The role of pro-inflammatory cytokine IL-17A for AECII ferroptosis, and the effect of Sal on HALT were investigated by administration of Y-320 (IL-17 inhibitor) and Sal respectively 3 days before mice exposed to hyperoxia.
   Results: Mice exposed to hyperoxia for 24 h suffered sufficient HALI with inflammatory cell infiltration and collagen deposition, and exhibited features of ferroptosis under TME. Meanwhile, compared with sham mice, mice exposed to hyperoxia showed down-regulation of GPX4, and up-regulation of IL-6, TGF-beta 1, IL-17A, IL-17RA, Act1, TRAF6, p38 MAPK and p-p38 MAPK. Moreover, inhibition of IL-17A with Y-320 or administration with Sal could reverse the effect caused by hyperoxia respectively.
   Conclusions: IL-17A is associated with immune cells infiltration in HALI, and contributes to ferroptosis of AECII that related to Act1/TRAF6/p38 MAPK pathway. Additionally, Sal protects against HALI throughout the whole pathogenic process.
C1 [Guo, Baoyue; Di, Xingwei; Xu, Bo; Liang, Zhuang; Hu, Zhansheng] Jinzhou Med Univ, Affiliated Hosp 1, Intens Care Unit, 2,Sect 5,Renmin St, Jinzhou 121012, Peoples R China.
   [Zuo, Zhongfu; Huang, Ying; Liu, Xuezheng] Jinzhou Med Univ, Dept Anat Histol & Embryol, Liaoning Key Lab Diabet Cognit & Percept Dysfunct, Jinzhou 121001, Peoples R China.
   [Gong, Gu; Wang, Lulu] Cent Hosp Jinzhou, Intens Care Unit, Jinzhou 121001, Peoples R China.
   [Zhang, Xiaoyu] Cent Hosp Dandong, Intens Care Unit, Dandong 118002, Peoples R China.
   [Hou, Yang] Jinzhou Med Univ, Coll Biol Informat Engn, Jinzhou 121001, Peoples R China.
C3 Jinzhou Medical University; Jinzhou Medical University; Jinzhou Medical
   University
RP Hu, ZS (corresponding author), Jinzhou Med Univ, Affiliated Hosp 1, Intens Care Unit, 2,Sect 5,Renmin St, Jinzhou 121012, Peoples R China.; Liu, XZ (corresponding author), Jinzhou Med Univ, Dept Anat Histol & Embryol, Liaoning Key Lab Diabet Cognit & Percept Dysfunct, Jinzhou 121001, Peoples R China.
EM liuxuezheng@jzmu.edu.cn; ICUHZS@163.com
FU key R&D projects of Liaoning Provincial Department of science and
   technology [2020JH2/10100017]; Natural Science Foundation of Liaoning
   Province [20180550197]
FX This work was supported by the key R&D projects of Liaoning Provincial
   Department of science and technology (2020JH2/10100017) and Natural
   Science Foundation of Liaoning Province (20180550197).
CR [Anonymous], STRING 11 0 DATABASE
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NR 37
TC 79
Z9 89
U1 3
U2 28
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1478-811X
J9 CELL COMMUN SIGNAL
JI Cell Commun. Signal.
PD NOV 21
PY 2022
VL 20
IS 1
AR 183
DI 10.1186/s12964-022-00994-1
PG 13
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA 6I6IU
UT WOS:000886235100001
PM 36411467
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xie, D
   Zhang, P
   You, SX
   Shen, Y
   Xu, WW
   Zhan, CS
   Zhang, JE
AF Xie, Dong
   Zhang, Pei
   You, Suxin
   Shen, Yue
   Xu, Wenwen
   Zhan, Changsen
   Zhang, Jiange
TI Salidroside derivative SHPL-49 attenuates glutamate excitotoxicity in
   acute ischemic stroke via promoting NR2A-CAMKIIα-Akt /CREB pathway
SO PHYTOMEDICINE
LA English
DT Article
DE Salidroside derivative; Acute ischemic stroke; Glutamate excitotoxicity;
   NMDA; CaMKII alpha
ID SYNAPTIC NMDA RECEPTOR; OXIDATIVE STRESS; NEURONAL DAMAGE; CAMKII;
   NEURODEGENERATION; PHOSPHORYLATION; MECHANISMS; BINDING; PROTEIN; MEMORY
AB Background: Ischemic stroke is a significant cause of death and disability with a limited treatment time window. The reduction of early glutamate excitotoxicity using neuroprotective agents targeting N-methyl-D-aspartic acid (NMDA) receptors have attracted recent research attention. SHPL-49, a structurally modified derivative of salidroside, was synthesized by our team. Previous studies have confirmed the neuroprotective efficacy of SHPL-49 in rats with ischemic stroke. However, the underlying mechanisms need to be clarified. Methods: We conducted in vivo experiments using the permanent middle cerebral artery occlusion rat model to investigate the role of SHPL-49 in glutamate release at different time points and treatment durations. Glutamate transporters and receptor proteins and neural survival proteins in the brain were also examined at the same time points. In vitro, primary neurons and the coculture system of primary neurons-astrocytes were subjected to oxygen-glucose deprivation and glutamate injury. Proteomics and parallel reaction monitoring analyses were performed to identify potential therapeutic targets of SHPL-49, which were further confirmed through in vitro experiments on the inhibition and mutation of the target. Results: SHPL-49 significantly reduced glutamate release caused by hypoxia-ischemia. One therapeutic pathway of SHPL-49 was promoting the expression of glutamate transporter-1 to increase glutamate reuptake and further reduce the occurrence of subsequent neurotoxicity. In addition, we explored the therapeutic targets of SHPL-49 and its regulatory effects on glutamate receptors for the first time. SHPL-49 enhanced neuroprotection by activating the NMDA subunit NR2A, which upregulated the cyclic-AMP response binding protein (CREB) neural survival pathway and Akt phosphorylation. Since calcium/calmodulin-dependent kinase II alpha (CaMKII alpha) is necessary for synaptic transmission of NMDA receptors, we explored the interaction between CaMKII alpha and SHPL49, which protected CaMKII alpha from hypoxia-ischemia-induced autophosphorylation damage. Conclusion: Overall, SHPL-49 enhanced neuronal survival and attenuated acute ischemic stroke by promoting the NR2A-CAMKII alpha-Akt/CREB pathway. Our study provides the first evidence demonstrating that the neuroprotective effect of SHPL-49 is achieved by promoting the NR2A subunit to extend the treatment time window, making it a promising drug for ischemic stroke.
C1 [Xie, Dong; Zhang, Pei; You, Suxin; Shen, Yue; Zhang, Jiange] Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit, Res Ctr Chiral Drugs, Chinese Med IRI, 1200 Cailun Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China.
   [Xu, Wenwen; Zhan, Changsen] Shanghai Hutchison Pharmaceut Co Ltd, Shanghai 201400, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Zhang, JE (corresponding author), Shanghai Univ Tradit Chinese Med, Innovat Res Inst Tradit, Res Ctr Chiral Drugs, Chinese Med IRI, 1200 Cailun Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China.
EM jgzhang@shutcm.edu.cn
RI Xu, Wenwen/AAD-9116-2019
FU Shanghai Municipal Health Commission/Shanghai Municipal Administration
   of Traditional Chinese Medicine [ZY(2021-2023)-0501]; Shanghai Science
   and Technology Development Fund from Central Leading Local Government
   [YDZX20223100001004]; The 2020 Shanghai science and technology
   innovation action plan biomedical science and technology support for
   special projects [20S11904400]; Open Project of National Major
   Scientific and Technological Infrastructure for Translational Medicine
   (Shanghai) [TMSK-2021-405]; Shanghai Frontiers Science Center for
   Traditional Chinese Medicine Chemical Biology
FX This work was supported by Shanghai Frontiers Science Center for
   Traditional Chinese Medicine Chemical Biology, Shanghai Municipal Health
   Commission/Shanghai Municipal Administration of Traditional Chinese
   Medicine (ZY(2021-2023)-0501), Shanghai Science and Technology
   Development Fund from Central Leading Local Government
   (YDZX20223100001004), "2020 Shanghai science and technology innovation
   action plan" biomedical science and technology support for special
   projects (20S11904400), Open Project of National Major Scientific and
   Technological Infrastructure for Translational Medicine (Shanghai)
   (TMSK-2021-405).
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NR 48
TC 15
Z9 17
U1 2
U2 23
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD NOV
PY 2024
VL 134
AR 155583
DI 10.1016/j.phymed.2024.155583
EA AUG 2024
PG 14
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA E1J6X
UT WOS:001300644800001
PM 39173548
DA 2026-05-27
ER

PT J
AU Godara, P
   Reddy, KS
   Sahu, W
   Naik, B
   Srivastava, V
   Das, R
   Mahor, A
   Kumar, P
   Giri, R
   Anirudh, J
   Tak, H
   Banavath, HN
   Bhatt, TK
   Goyal, AK
   Prusty, D
AF Godara, Priya
   Reddy, K. Sony
   Sahu, Welka
   Naik, Biswajit
   Srivastava, Varshita
   Das, Rusham
   Mahor, Ajay
   Kumar, Prateek
   Giri, Rajanish
   Anirudh, Jivanage
   Tak, Harshita
   Banavath, Hemanth Naick
   Bhatt, Tarun Kumar
   Goyal, Amit Kumar
   Prusty, Dhaneswar
TI Structure-based virtual screening against multiple Plasmodium
   falciparum kinases reveals antimalarial compounds
SO MOLECULAR DIVERSITY
LA English
DT Article
DE Drug resistance; Drug discovery; Inhibition assay; Virtual screening;
   Molecular dynamics; Multitargeting
ID PROTEIN; MYRICETIN; DYNAMICS; BINDING; TRANSMISSION; ARTEMISININ;
   FLAVONOIDS; RESISTANCE; INHIBITORS; QUERCETIN
AB The continuous emergence of resistance against most frontline antimalarial drugs has led to countless deaths in malaria-endemic countries, counting 619,000 deaths in 2021, with mutation in drug targets being the sole cause. As mutation is correlated frequently with fitness cost, the likelihood of mutation emergence in multiple targets at a time is extremely low. Hence, multitargeting compounds may seem promising to address drug resistance issues with additional benefits like increased efficacy, improved safety profile, and the requirement of fewer pills compared to traditional single and combinational drugs. In this study, we attempted to use the High Throughput Virtual Screening approach to predict multitarget inhibitors against six chemically validated Plasmodium falciparum (Pf) kinases (PfPKG, PfMAP2, PfCDPK4, PfTMK, PfPK5, PfPI4K), resulting in 21 multitargeting hits. The molecular dynamic simulation of the top six complexes (Myricetin-MAP2, Quercetin-CDPK4, Myricetin-TMK, Quercetin-PKG, Salidroside-PK5, and Salidroside-PI4K) showed stable interactions. Moreover, hierarchical clustering reveals the structural divergence of the compounds from the existing antimalarials, indicating less chance of cross-resistance. Additionally, the top three hits were validated through parasite growth inhibition assays, with quercetin and myricetin exhibiting an IC50 value of 1.84 and 3.93 mu M, respectively.
C1 [Godara, Priya; Naik, Biswajit; Srivastava, Varshita; Prusty, Dhaneswar] Cent Univ Rajasthan, Sch Life Sci, Dept Biochem, NH-8, Kishangarh Ajmer 305817, Rajasthan, India.
   [Reddy, K. Sony; Sahu, Welka] Kalinga Inst Ind Technol Deemed Univ, Sch Biotechnol, Bhubaneswar 751024, India.
   [Das, Rusham; Mahor, Ajay; Goyal, Amit Kumar] Cent Univ Rajasthan, Sch Chem Sci & Pharm, Dept Pharm, NH-8, Ajmer 305817, Rajasthan, India.
   [Kumar, Prateek; Giri, Rajanish] Indian Inst Technol Mandi, Sch Basic Sci, Kamand, India.
   [Anirudh, Jivanage; Tak, Harshita; Banavath, Hemanth Naick] Cent Univ Rajasthan, Sch Sport Sci, Dept Sports Biosci, Ajmer, India.
   [Bhatt, Tarun Kumar] Cent Univ Rajasthan Kishangarh, Sch Life Sci, Dept Biotechnol, NH-8, Ajmer 305817, Rajasthan, India.
C3 Central University of Rajasthan (CURAJ); Kalinga Institute of Industrial
   Technology (KIIT); Central University of Rajasthan (CURAJ); Indian
   Institute of Technology System (IIT System); Indian Institute of
   Technology (IIT) - Mandi; Central University of Rajasthan (CURAJ);
   Central University of Rajasthan (CURAJ)
RP Prusty, D (corresponding author), Cent Univ Rajasthan, Sch Life Sci, Dept Biochem, NH-8, Kishangarh Ajmer 305817, Rajasthan, India.
EM dhaneswarprusty@curaj.ac.in
RI Kumar, Prateek/MVW-1749-2025; Reddy, K. Sony/JCE-6323-2023;
   /S-6908-2019; Tak, Harshita/JFJ-9584-2023; Giri, Rajanish/Q-6530-2018;
   Bhatt, Tarun Kumar/AFD-8503-2022; Goyal, Amit/HTM-3887-2023; Mahor, Dr.
   Ajay/AFH-7752-2022
OI Kumar, Prateek/0000-0001-7392-5045; Reddy, K. Sony/0000-0002-8437-5250; 
FU Central University of Rajasthan; ICMR
FX PG is thankful to the Central University of Rajasthan for providing the
   University fellowship. WS acknowledges ICMR, Govt. of India, for the SRF
   Fellowship. DP is thankful to the Central University of Rajasthan for
   providing the computational facility.
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NR 84
TC 5
Z9 5
U1 0
U2 3
PU SPRINGER
PI DORDRECHT
PA VAN GODEWIJCKSTRAAT 30, 3311 GZ DORDRECHT, NETHERLANDS
SN 1381-1991
EI 1573-501X
J9 MOL DIVERS
JI Mol. Divers.
PD DEC
PY 2024
VL 28
IS 6
BP 3661
EP 3681
DI 10.1007/s11030-023-10770-z
EA DEC 2023
PG 21
WC Biochemistry & Molecular Biology; Chemistry, Applied; Chemistry,
   Medicinal; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA P8R3G
UT WOS:001130315400001
PM 38127294
DA 2026-05-27
ER

PT J
AU Fu, Y
   Huang, GQ
   Cai, YW
   Ren, MH
   Cheng, R
   Chai, YH
   Wang, YD
   An, YQ
   Yan, TH
   Zhu, LP
   Liu, XX
AF Fu, Yu
   Huang, Guiqin
   Cai, Yawen
   Ren, Menghui
   Cheng, Run
   Chai, Yuhui
   Wang, Yingdi
   An, Yunqi
   Yan, Tianhua
   Zhu, Lingpeng
   Liu, Xinxin
TI Integrated network pharmacology, bioinformatics, and experiment analysis
   to decipher the molecular mechanism of Salidroside on Gastric cancer via
   targeting NCOA4-mediated ferritinophagy
SO CHEMICO-BIOLOGICAL INTERACTIONS
LA English
DT Article
DE Salidroside; Gastric cancer; Ferroptosis; NCOA4; Mitochondrial
   dysfunction; Ferritinophagy
ID CELL-DEATH; FERROPTOSIS
AB Gastric cancer (GC) is a highly aggressive and heterogeneous malignancy. The process of ferroptosis regulates tumor growth and represents a promising therapeutic target for GCs. Despite Salidroside (Sal) being able to regulate ferroptosis in a variety of diseases, there are still limited reports on its therapeutic effects and potential targets in treating GC. This study aimed to investigate the potential mechanism of Sal-induced ferroptosis in GC. Our analysis, integrating databases like PharmMapper, Swiss Target Prediction, TargetNet, GeneCards, TTD, OMIM, STRING, and DAVID. Human gastric cancer MGC803 cells and tumor-bearing mice were used to evaluate the anti-tumor effect of Sal on GC in vitro and in vivo. CCK-8, LDH, and Calcein-AM/PI were used to assess cell viability and damage. FerroOrange, Lillie's Ferrous Iron Stain, MDA, ROS, BODIPYTM 581/591C11, GSH, and GPxs were used to detect intracellular Fe2+ concentration, lipid peroxidation level, and antioxidant defense system. qRT-PCR and Western blot were performed to explore relevant mechanism studies. Network pharmacology results showed that Sal shares 322 targets with GC, which have biological functions related to lipid metabolism, cell death, and lipid peroxidation. Experiments further confirmed that Sal inhibits MGC803 cells by inducing ferroptosis, as evidenced by the induction of elevated Fe2+ and increased lipid peroxidation. Fer-1, an inhibitor of ferroptosis, reversed the anti-GC effect of Sal in MGC803 cells and GC tumor-bearing mice. Further confirmation of the association between Sal and ferroptosis in GC. Subsequently, bioinformatics and machine learning algorithms identified nuclear receptor coactivator 4 (NCOA4) as a candidate signature gene associated with ferroptosis in GC, and molecular docking shows that NCOA4 binds Sal. We then performed in vivo and in vitro experiments to elucidate that Sal targeting NCOA4, a cargo receptor mediating ferritinophagy, mediates autophagic degradation of ferritin heavy chain 1 (FTH1, Fe2+ storage protein), which further increases Fe2+ and lipid peroxidation. In addition, Sal induces mitochondrial dysfunction and increases mitochondrial ROS levels, which activates autophagy and triggers autophagic degradation of FTH1. Taken together, we revealed that NCOA4 is a new target for Sal-anchored GC and that Sal may be a potential therapeutic drug for the treatment of GC.
C1 [Fu, Yu; Huang, Guiqin; Cai, Yawen; Ren, Menghui; Cheng, Run; Chai, Yuhui; Wang, Yingdi; Yan, Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Jiangsu, Peoples R China.
   [Zhu, Lingpeng] Nanjing Med Univ, Wuxi Peoples Hosp, Wuxi Med Ctr, Wuxi, Jiangsu, Peoples R China.
   [Liu, Xinxin] Nanjing Univ Chinese Med, Affiliated Hosp, Jiangsu Prov Hosp Chinese Med, Gen Surg Dept, Nanjing, Jiangsu, Peoples R China.
   [An, Yunqi] Rutgers State Univ, Ernest Mario Sch Pharm, Dept Pharmacol & Toxicol, Piscataway, NJ 08854 USA.
C3 China Pharmaceutical University; Jiangnan University; Nanjing Medical
   University; Nanjing University of Chinese Medicine; Rutgers University
   System; Rutgers University New Brunswick
RP Yan, TH (corresponding author), China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Jiangsu, Peoples R China.; Zhu, LP (corresponding author), Nanjing Med Univ, Wuxi Peoples Hosp, Wuxi Med Ctr, Wuxi, Jiangsu, Peoples R China.; Liu, XX (corresponding author), Nanjing Univ Chinese Med, Affiliated Hosp, Jiangsu Prov Hosp Chinese Med, Gen Surg Dept, Nanjing, Jiangsu, Peoples R China.
EM 1020050806@cpu.edu.cn; zhulingpeng@njmu.edu.cn; gorilla1999@hotmail.com
RI Cai, Yawen/OKR-6198-2025; Su, Tianyuan/Y-7054-2019; Liu,
   xinxin/GYD-5918-2022; An, Yunqi/MXL-8576-2025
FU National Natural Science Foundation of China [82201220]; Natural Science
   Foundation of Jiangsu Province [BK20190149]; Postdoctoral Science
   Foundation of China [2020M681669]; Postgraduate Research & Practice
   Innovation Program of Jiangsu Province [KYCX24_2248]
FX The National Natural Science Foundation of China (No. 82201220) , the
   Natural Science Foundation of Jiangsu Province (No. BK20190149) , the
   Postdoctoral Science Foundation of China (No. 2020M681669) , and the
   Postgraduate Research & Practice Innovation Program of Jiangsu Province
   (KYCX24_2248) all provided support for the work.
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NR 36
TC 9
Z9 10
U1 6
U2 14
PU ELSEVIER IRELAND LTD
PI CLARE
PA ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000,
   IRELAND
SN 0009-2797
EI 1872-7786
J9 CHEM-BIOL INTERACT
JI Chem.-Biol. Interact.
PD FEB 1
PY 2025
VL 407
AR 111368
DI 10.1016/j.cbi.2024.111368
EA JAN 2025
PG 17
WC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology
GA S6I2U
UT WOS:001399229800001
PM 39746501
OA hybrid
DA 2026-05-27
ER

PT J
AU Chu, XR
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AF Chu, Xueru
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   Xin, Yongning
   Lu, Linlin
TI Salidroside may target PPARα to exert preventive and therapeutic
   activities on NASH
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE salidroside; non-alcoholic steatohepatitis; prevention; therapy;
   immunity; inflammation; PPAR alpha
ID FATTY LIVER-DISEASE; NONALCOHOLIC STEATOHEPATITIS; AUTOPHAGY; NAFLD;
   MICE
AB Background Salidroside (SDS), a phenylpropanoid glycoside, is an antioxidant component isolated from the traditional Chinese medicine Rhodiola rosea and has multifunctional bioactivities, particularly possessing potent hepatoprotective function. Non-alcoholic steatohepatitis (NASH) is one of the most prevalent chronic liver diseases worldwide, but it still lacks efficient drugs. This study aimed to assess the preventive and therapeutic effects of SDS on NASH and its underlying mechanisms in a mouse model subjected to a methionine- and choline-deficient (MCD) diet.Methods C57BL/6J mice were fed an MCD diet to induce NASH. During or after the formation of the MCD-induced NASH model, SDS (24 mg/kg/day) was supplied as a form of diet for 4 weeks. The histopathological changes were evaluated by H&E staining. Oil Red O staining and Sirius Red staining were used to quantitatively determine the lipid accumulation and collagen fibers in the liver. Serum lipid and liver enzyme levels were measured. The morphology of autophagic vesicles and autophagosomes was observed by transmission electron microscopy (TEM), and qRT-PCR and Western blotting were used to detect autophagy-related factor levels. Immunohistochemistry and TUNEL staining were used to evaluate the apoptosis of liver tissues. Flow cytometry was used to detect the composition of immune cells. ELISA was used to evaluate the expression of serum inflammatory factors. Transcript-proteome sequencing, molecular docking, qRT-PCR, and Western blotting were performed to explore the mechanism and target of SDS in NASH.Results The oral administration of SDS demonstrated comprehensive efficacy in NASH. SDS showed both promising preventive and therapeutic effects on NASH in vivo. SDS could upregulate autophagy, downregulate apoptosis, rebalance immunity, and alleviate inflammation to exert anti-NASH properties. Finally, the results of transcript-proteome sequencing, molecular docking evaluation, and experimental validation showed that SDS might exert its multiple effects through targeting PPAR alpha.Conclusion Our findings revealed that SDS could regulate liver autophagy and apoptosis, regulating both innate immunity and adaptive immunity and alleviating inflammation in NASH prevention and therapy via the PPAR pathway, suggesting that SDS could be a potential anti-NASH drug in the future.
C1 [Chu, Xueru; Xin, Yongning] Ocean Univ China, Qingdao Municipal Hosp, Sch Med & Pharm, Dept Infect Dis, Qingdao, Peoples R China.
   [Chu, Xueru; Xin, Yongning] Qingdao Municipal Hosp, Dept Infect Dis, Qingdao, Peoples R China.
   [Liu, Shousheng] Univ Hlth & Rehabil Sci, Qingdao Municipal Hosp, Clin Res Ctr, Qingdao, Peoples R China.
   [Qu, Baozhen; Lu, Linlin] Univ Hlth & Rehabil Sci, Qingdao Cent Hosp, Qingdao Canc Prevent & Treatment Res Inst, Qingdao, Peoples R China.
C3 Ocean University of China; Qingdao Municipal Hospital; Qingdao Municipal
   Hospital; University of Health & Rehabilitation Sciences; Qingdao
   Municipal Hospital; University of Health & Rehabilitation Sciences
RP Xin, YN (corresponding author), Ocean Univ China, Qingdao Municipal Hosp, Sch Med & Pharm, Dept Infect Dis, Qingdao, Peoples R China.; Xin, YN (corresponding author), Qingdao Municipal Hosp, Dept Infect Dis, Qingdao, Peoples R China.; Lu, LL (corresponding author), Univ Hlth & Rehabil Sci, Qingdao Cent Hosp, Qingdao Canc Prevent & Treatment Res Inst, Qingdao, Peoples R China.
EM lulinlin2007@hotmail.com; xinyongning@163.com
FU National Natural Science Foundation of China [31800660]
FX The author(s) declare that financial support was received for the
   research, authorship, and/or publication of this article. This study was
   supported by the National Natural Science Foundation of China (grant
   number: 31800660).
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NR 60
TC 6
Z9 6
U1 3
U2 10
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD OCT 2
PY 2024
VL 15
AR 1433076
DI 10.3389/fphar.2024.1433076
PG 17
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA I7A7Y
UT WOS:001331754000001
PM 39415834
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wiedenfeld, H
   Dumaa, M
   Malinowski, M
   Furmanowa, M
   Narantuya, S
AF Wiedenfeld, H.
   Dumaa, M.
   Malinowski, M.
   Furmanowa, M.
   Narantuya, S.
TI Phytochemical and analytical studies of extracts from Rhodiola
   rosea and Rhodiola quadrifida
SO PHARMAZIE
LA English
DT Article
ID MAGNETIC-RESONANCE; UNDERGROUND PART; DOUBLE-BLIND; PALL FISCH;
   PERFORMANCE; GLYCOSIDES; FATIGUE; STRESS; ROOTS; SHR-5
AB Column chromatography of hydrophilic extracts from Rhodiola rosea and Rodiola quadrifida led to the isolation of cinnamic alcohol, chlorogenic acid, rhodiooctanoside, rosiridin, rosavin and the phenolic compounds salidroside, rhodiolin and a novel compound consisting of viridoside with an attached arabinose unit (mongrhoside). HPLC analysis of plant material from different sources and from different collection periods showed a great variability in the composition and in the amount of pharmacologically active compounds contained.
C1 Univ Bonn, Inst Pharmazeut, D-53121 Bonn, Germany.
   MAS, Inst Chem & Chem Technol, Ulaanbaatar, Mongolia.
   Med Univ Warsaw, Dept Biol & Pharmaceut Bot, Warsaw, Poland.
C3 University of Bonn; Mongolian Academy of Sciences; Medical University of
   Warsaw
RP Wiedenfeld, H (corresponding author), Univ Bonn, Inst Pharmazeut, Immenburg 4, D-53121 Bonn, Germany.
EM wiedenfeld@uni-bonn.de
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NR 27
TC 75
Z9 78
U1 0
U2 53
PU GOVI-VERLAG  PHARMAZEUTISCHER VERLAG GMBH
PI ESCHBORN
PA PHARMAZEUTISCCARL MANNICH STR 26, D-65760 ESCHBORN, GERMANY
SN 0031-7144
J9 PHARMAZIE
JI Pharmazie
PD APR
PY 2007
VL 62
IS 4
BP 308
EP 311
DI 10.1691/ph.2007.4.6664
PG 4
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA 154TG
UT WOS:000245530000014
PM 17484290
DA 2026-05-27
ER

PT J
AU Hao, YJ
   Li, ZY
   Chang, MZ
   Zhang, XL
AF Hao, Yanjiao
   Li, Zhiyu
   Chang, Mingzhi
   Zhang, Xiaoli
TI Effects of Salidroside Combined with Paclitaxel on Proliferation,
   Migration, and Epithelial Mesenchyme of Colorectal Cancer Cells
SO DRUG DESIGN DEVELOPMENT AND THERAPY
LA English
DT Article
DE salidroside; paclitaxel; colorectal cancer; apoptosis; PI3K; AKT
   signaling pathway; EMT
AB Background: Colorectal cancer (CRC) is a multifactorial disease and one of the most common malignancies worldwide. Salidroside (Sal) is a plant with a wide range of pharmacological effects and plays an important role in the treatment of many diseases, and is considered a new hope for the treatment of tumors. The purpose of this study was to investigate the effect of the combination of Sal and paclitaxel (Pac) on colorectal cancer cells and its mechanism of action.Methods: The effects of different mass concentrations of Sal, Pac, and the combination intervened in the cells for 48 h were examined using the CCK8 method. The inhibition rate was obtained, and the optimal concentration of the respective drug group was screened. The proliferative capacity of the respective group was obtained. Subsequently, the results of apoptosis, cloning, migration, invasion, and angiogenesis were observed through cell morphological analysis (shape observation and Hoechst staining), colony formation assay, cell scratching assay, Transwell, angiogenesis assay, and protein immunoblotting (Western blotting) to detect the expression of epithelial-mesenchymal transition (EMT)-associated proteins and PI3K pathway-associated proteins.Results: Different concentrations of Sal, Pac, and the combined application had significant effects in inhibiting cells in a concentration-dependent manner. Compared with the control group, the Sal group, the Pac group, and the combination group significantly inhibited the clonal number, migration, invasion, and tube-forming ability of colorectal cancer cells. Besides, the combined application had a better effect than the Sal and Pac groups. The apoptosis level was up-regulated in all drug groups, and the up-regulation was more significant in the combination group. The expression of E-cad protein was up-regulated, the expression of N-cad and Vim protein was down-regulated, and the expression of PI3K and AKT phosphorylation was down-regulated in the respective group, and the difference was more significant in the combination group compared with the group of individual drugs.Conclusion: The combined application of Sal and Pac significantly can decrease the survival rate of colorectal cancer cells, and the mechanism may be correlated with the blocking of the PI3K/AKT pathway, thus inhibiting EMT.
C1 [Hao, Yanjiao; Li, Zhiyu; Chang, Mingzhi; Zhang, Xiaoli] Hebei North Univ, Coll Basic Med, Dept Life Sci Res Ctr, Zhangjiakou 075000, Hebei, Peoples R China.
C3 Hebei North University
RP Zhang, XL (corresponding author), Hebei North Univ, Coll Basic Med, Dept Life Sci Res Ctr, Zhangjiakou 075000, Hebei, Peoples R China.
EM 894915208@qq.com
RI Zhang, Xiaoli/KMY-2764-2024
FU Natural Science Research Program of Hebei North College;  [YB2018008]
FX Funding The authors thank the Natural Science Research Program of Hebei
   North College for providing financial support for this study (NO.
   YB2018008) .
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NR 23
TC 14
Z9 16
U1 0
U2 6
PU DOVE MEDICAL PRESS LTD
PI ALBANY
PA PO BOX 300-008, ALBANY, AUCKLAND 0752, NEW ZEALAND
SN 1177-8881
J9 DRUG DES DEV THER
JI Drug Des. Dev. Ther.
PY 2022
VL 16
BP 4079
EP 4089
DI 10.2147/DDDT.S384151
PG 11
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6P6YK
UT WOS:000891074200001
PM 36465266
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, JX
   Cai, JP
   Fan, P
   Dong, X
   Zhang, NS
   Tai, JD
   Cao, YG
AF Liu, Jiuxi
   Cai, Jiapei
   Fan, Peng
   Dong, Xue
   Zhang, Naisheng
   Tai, Jiandong
   Cao, Yongguo
TI Salidroside alleviates dextran sulfate sodium-induced colitis in mice by
   modulating the gut microbiota
SO FOOD & FUNCTION
LA English
DT Article
ID ULCERATIVE-COLITIS; BARRIER; INFLAMMATION; MODEL
AB Dysbiosis causes continuous progress of inflammatory bowel disease (IBD). Herein, we aim to explore whether Salidroside (Sal), which is a major glycoside extracted from Rhodiola rosea L., could ameliorate dextran sulfate sodium (DSS)-induced colitis by modulating the microbiota. Results showed that oral treatment with 15 mg kg(-1) of Sal inhibited DSS-induced colitis in mice as evidenced by colon length, histological analysis, disease activity index (DAI) score, and the proportion and number of macrophages in the intestine. The gut microbiota of colitic mice was also partly restored by Sal. A fecal microbiota transplantation (FMT) study was designed to verify the causality. Compared with DSS-treated mice, FM from the Sal-treated donor mice significantly mitigated the symptoms of colitic mice, including reducing the DAI score, alleviating tissue damage, boosting the expression of mucin protein (mucin-2) and tight junction (TJ) proteins (occludin and zonula occludens-1 (ZO-1), and decreasing M1 macrophages in the gut. It was found that both Sal and FMT affected the structure and abundance of the gut microbiota as reflected by the decreased relative abundance of Turicibacter, Alistipes, Romboutsia and the increased relative abundance of Lactobacillus at the genus level. Moreover, the anti-inflammatory effect of Sal disappeared when the gut microbiota was depleted by antibiotics, demonstrating that Sal alleviated the intestinal inflammation in a gut microbiota-dependent manner. Thus, Sal could be a remarkable candidate as a functional food for colitis.
C1 [Liu, Jiuxi; Cai, Jiapei; Fan, Peng; Dong, Xue; Zhang, Naisheng; Cao, Yongguo] Jilin Univ, Coll Vet Med, Dept Clin Vet Med, Changchun 130062, Peoples R China.
   [Liu, Jiuxi] Chinese Acad Sci, Guangzhou Inst Biomed & Hlth, CAS Key Lab Regenerat Biol, Guangdong Prov Key Lab Stem Cell & Regenerat Med, Guangzhou 510530, Peoples R China.
   [Tai, Jiandong] First Hosp Jilin Univ, Gen Surg Ctr, Dept Colorectal & Anal Surg, Changchun 130021, Peoples R China.
   [Cao, Yongguo] Jilin Univ, Coll Vet Med, Key Lab Zoonosis Res, Minist Educ, Changchun 130062, Peoples R China.
C3 Jilin University; Chinese Academy of Sciences; Guangzhou Institute of
   Biomedicine & Health, CAS; Jilin University; Jilin University
RP Cao, YG (corresponding author), Jilin Univ, Coll Vet Med, Dept Clin Vet Med, Changchun 130062, Peoples R China.; Tai, JD (corresponding author), First Hosp Jilin Univ, Gen Surg Ctr, Dept Colorectal & Anal Surg, Changchun 130021, Peoples R China.; Cao, YG (corresponding author), Jilin Univ, Coll Vet Med, Key Lab Zoonosis Res, Minist Educ, Changchun 130062, Peoples R China.
EM taijd@jlu.edu.cn; ygcao82@jlu.edu.cn
RI Fan, Peng/OIS-5642-2025
OI yongguo, Cao/0000-0002-9533-7516
FU Ministry of Science and Technology of the People's Republic of China
   [2016YFD0501009]
FX This study was supported by the Ministry of Science and Technology of
   the People's Republic of China (Grant Number: 2016YFD0501009).
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NR 48
TC 67
Z9 72
U1 4
U2 102
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
SN 2042-6496
EI 2042-650X
J9 FOOD FUNCT
JI Food Funct.
PD AUG 14
PY 2023
VL 14
IS 16
BP 7506
EP 7519
DI 10.1039/d3fo01929b
EA JUL 2023
PG 14
WC Biochemistry & Molecular Biology; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Food Science & Technology
GA O7UR8
UT WOS:001035010700001
PM 37504971
DA 2026-05-27
ER

PT J
AU Xu, H
   Gu, HX
   Yang, YH
   Cai, EG
   Ding, F
   Yu, S
AF Xu, Hui
   Gu, Huaxiang
   Yang, Yanhong
   Cai, Ergai
   Ding, Fei
   Yu, Shu
TI 2-(4-Methoxyphenyl)Ethyl-2-Acetamido-2-Deoxy-β-d-Pyranoside Exerts a
   Neuroprotective Effect through Regulation of Energy Homeostasis and
   O-GlcNAcylation
SO JOURNAL OF MOLECULAR NEUROSCIENCE
LA English
DT Article
DE 2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-beta-d-pyranoside;
   Neuroprotection; Energy homeostasis; O-GlcNAcylation; Ischemic stroke
ID GLUCOSE-METABOLISM; ISCHEMIC-STROKE; CELL-DEATH; IN-VITRO; SALIDROSIDE;
   MECHANISMS; INJURY; APOPTOSIS; SURVIVAL; GLCNAC
AB Dysfunction of energy metabolism exerts a central role in triggering neuron death following cerebral ischemia. Neuronal energy metabolism is highly dependent on glucose. O-GlcNAcylation, a post-translational modification, is a novel pro-survival pathway that modulates glucose homeostasis in ischemic stroke. Here, we explored whether activation O-GlcNAcylation and maintaining energy homeostasis mediated the neuroprotective effect of 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxy-beta-d-pyranoside, a synthetic salidroside analog (named SalA-4 g) which was previously developed in our laboratory. For in vivo analyses, SalA-4 g improved the outcome after transient middle cerebral artery occlusion (MCAO). F-18-FDG PET/MRI indicated that SalA-4 g accelerated the recovery of energy metabolism in the ipsilateral hippocampus in MCAO rats. In vitro analyses showed that glucose uptake was markedly increased, and O-GlcNAcylation was also activated by SalA-4 g in hippocampal neurons under both normal and oxygen glucose deprivation (OGD) conditions. Moreover, SalA-4 g exerted obvious neuroprotective effects in hippocampal neurons against moderate OGD injury. Our study indicates that boosting a pro-survival pathway-GlcNAcylation-and regulating energy homeostasis are important biochemical mechanisms responsible for SalA-4 g neuroprotection.
C1 [Xu, Hui; Gu, Huaxiang; Yang, Yanhong; Cai, Ergai; Ding, Fei; Yu, Shu] Nantong Univ, Coinnovat Ctr Neuroregenerat, Key Lab Neuroregenerat Jiangsu, 19 Qixiu Rd, Nantong 226001, JS, Peoples R China.
   [Xu, Hui; Gu, Huaxiang; Yang, Yanhong; Cai, Ergai; Ding, Fei; Yu, Shu] Nantong Univ, Minist Educ, 19 Qixiu Rd, Nantong 226001, JS, Peoples R China.
C3 Nantong University; Nantong University
RP Yu, S (corresponding author), Nantong Univ, Coinnovat Ctr Neuroregenerat, Key Lab Neuroregenerat Jiangsu, 19 Qixiu Rd, Nantong 226001, JS, Peoples R China.; Yu, S (corresponding author), Nantong Univ, Minist Educ, 19 Qixiu Rd, Nantong 226001, JS, Peoples R China.
EM yushu@ntu.edu.cn
RI ; DING, FEI/KLD-8925-2024
OI Yu, Shu/0000-0003-3771-267X; 
FU National Key Basic Research Program of China (973 Program)
   [2014CB542203]; National Natural Science Foundation of China [81401094];
   Undergraduate Innovation Training Programs of Nantong University -
   Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD) [201810304104X]
FX This work was supported by the National Key Basic Research Program of
   China (973 Program, Grant No. 2014CB542203), National Natural Science
   Foundation of China (Grant No. 81401094), and the Undergraduate
   Innovation Training Programs of Nantong University (Grant No.
   201810304104X), a Project Funded by the Priority Academic Program
   Development of Jiangsu Higher Education Institutions (PAPD).
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NR 30
TC 7
Z9 8
U1 0
U2 11
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
SN 0895-8696
EI 1559-1166
J9 J MOL NEUROSCI
JI J. Mol. Neurosci.
PD OCT
PY 2019
VL 69
IS 2
BP 177
EP 187
DI 10.1007/s12031-019-01347-3
PG 11
WC Biochemistry & Molecular Biology; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Neurosciences & Neurology
GA IV9ZU
UT WOS:000484623000001
PM 31201658
DA 2026-05-27
ER

PT J
AU Liu, SS
   Yu, XW
   Hu, BJ
   Zou, Y
   Li, JB
   Bo, LL
   Deng, XM
AF Liu, Shanshan
   Yu, Xiongwei
   Hu, Baoji
   Zou, Yun
   Li, Jinbao
   Bo, Lulong
   Deng, Xiaoming
TI Salidroside rescued mice from experimental sepsis through
   anti-inflammatory and anti-apoptosis effects
SO JOURNAL OF SURGICAL RESEARCH
LA English
DT Article
DE Experimental sepsis; Proinflammatory response; Apoptosis; Bacterial
   clearance; Traditional Chinese medicine
ID IMMUNOSUPPRESSION; EXTRACT; MODEL
AB Background: Salidroside (SDS) is the main effective component of Rhodiola rosea L with a variety of pharmacologic properties. The objective of this study was to investigate the efficacy of SDS in the treatment of experimental sepsis in mice and explore the possible underlying action mechanisms.
   Methods: Sepsis was induced in C57BL/6 male mice via cecal ligation and puncture (CLP). The animals were divided into three groups as follows: sham, CLP, and CLP plus SDS. SDS (50 mg/kg) was injected intraperitoneally 1 h after operation. Postoperative survival of the mice, bacterial clearance in blood and peritoneal lavage fluid, cytokine secretion in blood, and histology of lung were evaluated. In addition, apoptosis of immune cells in the spleen and thymus were examined, respectively.
   Results: SDS administration prolonged the survival of the septic mice, inhibited the proinflammatory responses, and enhanced bacterial clearance. It also alleviated the pathologic changes in the lung and inhibited the apoptosis of immune cells in the spleen and thymus after CLP challenge.
   Conclusions: SDS exerts a protective effect in CLP-induced sepsis by attenuating the proinflammatory responses, enhancing bacterial clearance, and preserving adaptive immunity. SDS may be a promising therapeutic strategy for the treatment of sepsis. (C) 2015 Elsevier Inc. All rights reserved.
C1 [Liu, Shanshan; Yu, Xiongwei; Hu, Baoji; Zou, Yun; Li, Jinbao; Bo, Lulong; Deng, Xiaoming] Second Mil Med Univ, Changhai Hosp, Dept Anesthesiol & Intens Care, Shanghai 200433, Peoples R China.
   [Liu, Shanshan] Xiamen Univ, Chenggong Hosp, Dept Anesthesiol, Xiamen, Peoples R China.
   [Yu, Xiongwei] 285th Hosp CPLA, Dept Anesthesiol, Handan, Peoples R China.
   [Hu, Baoji] Fudan Univ, Pudong Med Ctr, Shanghai Pudong Hosp, Dept Anesthesiol, Shanghai 200433, Peoples R China.
C3 Naval Medical University; Xiamen University; Fudan University
RP Deng, XM (corresponding author), Second Mil Med Univ, Changhai Hosp, Dept Anesthesiol & Intens Care, Shanghai 200433, Peoples R China.
EM nbastars@126.com; deng_x@yahoo.com
RI Bo, Lulong/MVT-7945-2025; Deng, Xiaoming/E-2876-2010; Hu,
   Baoji/Z-4796-2019
OI Bo, Lulong/0000-0001-6787-1837; 
FU National Natural Science Foundation of China [81272065, 81471845,
   81171778, 81201492]; Shanghai Youth Physician Training Project
   [20141093]
FX This work was supported by research grants from the National Natural
   Science Foundation of China (No. 81272065, 81471845 to X.D.; No.
   81171778 to J.L.; No. 81201492 to L.B.), and Shanghai Youth Physician
   Training Project (No. 20141093 to L.B.). The foundations have no role in
   the study design, data collection and analysis, preparation of the
   article, and decision for publication.
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TC 33
Z9 40
U1 0
U2 30
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0022-4804
EI 1095-8673
J9 J SURG RES
JI J. Surg. Res.
PD MAY 1
PY 2015
VL 195
IS 1
BP 277
EP 283
DI 10.1016/j.jss.2015.01.021
PG 7
WC Surgery
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Surgery
GA CE9CA
UT WOS:000352139900036
PM 25676465
DA 2026-05-27
ER

PT J
AU Mease, J
   Reber, KP
AF Mease, James
   Reber, Keith P.
TI Total Synthesis of Clerobungin A via a Cascade Cyclization Reaction
SO JOURNAL OF ORGANIC CHEMISTRY
LA English
DT Article
ID BIOGENESIS-LIKE TRANSFORMATION; CYCLOHEXYLETHANOIDS; BIOSYNTHESIS;
   SALIDROSIDE; CORNOSIDE; ACETALS; KETALS
AB The first total synthesis of the novel cyclohexylethanoid natural product clerobungin A has been achieved in six steps and 14% overall yield starting from commercially available tyrosol. Key steps in this sequence include a bioinspired oxidative dearomatization of a phenol and a hemiacetalization/oxa-Michael cascade to form the tricyclic ring system. Resolution of a late-stage intermediate via chiral HPLC allowed for the measurement of the chiroptical properties of both enantiomers of clerobungin A, supporting the scalemic nature of the natural product.
C1 [Mease, James; Reber, Keith P.] Towson Univ, Dept Chem, 8000 York Rd, Towson, MD 21252 USA.
C3 University System of Maryland; Towson University
RP Reber, KP (corresponding author), Towson Univ, Dept Chem, 8000 York Rd, Towson, MD 21252 USA.
EM kreber@towson.edu
OI Mease, James/0009-0006-0428-2422
FU Towson University Office of Undergraduate Research (TOUR); Fisher
   College of Science and Mathematics (FCSM)
FX We gratefully acknowledge the Towson University Office of Undergraduate
   Research (TOUR) and the Fisher College of Science and Mathematics (FCSM)
   for supporting this work through undergraduate research grants. We also
   thank Christina Kraml and Laura Wilson (Lotus Separations) for
   performing preparative enantiomeric separations and Dr. John Eng
   (Princeton University) for assisting with high resolution mass spectral
   analyses. Finally, we would like to thank Tim Brunker, Mary Devadas, and
   John Sivey (Towson University) for helpful discussions and assistance
   with instrumentation.
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NR 29
TC 7
Z9 8
U1 1
U2 40
PU AMER CHEMICAL SOC
PI WASHINGTON
PA 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
SN 0022-3263
J9 J ORG CHEM
JI J. Org. Chem.
PD DEC 2
PY 2016
VL 81
IS 23
BP 12006
EP 12011
DI 10.1021/acs.joc.6b02261
PG 6
WC Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Chemistry
GA EE2EL
UT WOS:000389396400052
PM 27934453
DA 2026-05-27
ER

PT J
AU Li, RR
   Wang, SH
   Li, T
   Wu, LT
   Fang, Y
   Feng, Y
   Zhang, LL
   Chen, JZ
   Wang, X
AF Li, Ruru
   Wang, Songhai
   Li, Tao
   Wu, Leitao
   Fang, Yan
   Feng, Yang
   Zhang, Lingling
   Chen, Jianzong
   Wang, Xin
TI Salidroside Protects Dopaminergic Neurons by Preserving Complex I
   Activity via DJ-1/Nrf2-Mediated Antioxidant Pathway
SO PARKINSONS DISEASE
LA English
DT Article
AB The pathogenic mechanism of Parkinson's disease (PD) remains to be elucidated; however, mitochondrial dysfunction at the level of complex I and oxidative stress is suggestively involved in the development of PD. In our previous work, salidroside (Sal), an active component extracted from the medicinal plant Rhodiola rosea L., might protect dopaminergic (DA) neurons through modulating ROS-NO-related pathway. However, the mechanism of Sal-induced neuroprotective effects against PD remains poorly understood. Therefore, we further investigated whether Sal plays neuroprotective effects by activating complex I via DJ-1/Nrf2-mediated antioxidant pathway. The results showed that Sal remarkably attenuated MPP+/MPTP-induced decline in cell viability, accompanied by decreases in reactive oxygen species (ROS), malondialdehyde (MDA), and 8-hydroxy-deoxyguanosine (8-OHdG) contents and increases in the superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GSH-Px), as well as glutathione (GSH) levels. Furthermore, Sal greatly improved the behavioral performance and prevented the severe reduction of TH-positive neuron numbers in the substantia nigra (SN). Moreover, in comparison with the MPP+/MPTP group, Sal increased the nuclear translocation of DJ-1 and Nrf2 and the mitochondrial translocation of DJ-1, accompanied by activating complex I. Furthermore, silencing of DJ-1/Nrf2 inhibited the increase of complex I activity and cell viability elicited by Sal. Together, these results support the neuroprotective effect of Sal against MPP+/MPTP-induced DA neurons damage.
C1 [Li, Ruru; Wang, Songhai; Li, Tao; Wu, Leitao; Fang, Yan; Feng, Yang; Zhang, Lingling; Chen, Jianzong] Fourth Mil Med Univ, Xijing Hosp, Dept Chinese Med, Xian 710032, Shaanxi, Peoples R China.
   [Wang, Xin] Fourth Mil Med Univ, Fac Prevent Med, Dept Toxicol, Xian 710032, Shaanxi, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Chen, JZ (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Dept Chinese Med, Xian 710032, Shaanxi, Peoples R China.; Wang, X (corresponding author), Fourth Mil Med Univ, Fac Prevent Med, Dept Toxicol, Xian 710032, Shaanxi, Peoples R China.
EM jzchen57@fmmu.edu.cn; xinwang@fmmu.edu.cn
RI Li, Tao/LJM-1988-2024; Wang, Xin/AAJ-6869-2020
OI Wang, Xin/0000-0002-7296-9406; Li, Ruru/0000-0002-2927-7682; Zhang,
   Lingling/0000-0001-7555-8138
FU National Nature Science Foundation of China [81173590]
FX . is work was supported by the National Nature Science Foundation of
   China (Grant number 81173590).
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NR 36
TC 30
Z9 30
U1 1
U2 17
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-8083
EI 2042-0080
J9 PARKINSONS DIS-US
JI Parkinsons Dis.
PY 2019
VL 2019
AR 6073496
DI 10.1155/2019/6073496
PG 10
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA IA0PP
UT WOS:000469259100001
PM 31223467
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, L
   Qu, Y
   Jin, X
   Guo, XQ
   Wang, Y
   Qi, L
   Yang, J
   Zhang, P
   Li, LZ
AF Li, Ling
   Qu, Ye
   Jin, Xin
   Guo, Xiao Qin
   Wang, Yue
   Qi, Lin
   Yang, Jing
   Zhang, Peng
   Li, Ling Zhi
TI Protective effect of salidroside against bone loss via
   hypoxia-inducible factor-1α pathway-induced angiogenesis
SO SCIENTIFIC REPORTS
LA English
DT Article
ID MECHANICAL-PROPERTIES; MINERAL DENSITY; OSTEOBLAST; RALOXIFENE;
   DIFFERENTIATION; OSTEOGENESIS; OVARIECTOMY; EXPRESSION; TRANSCRIPTION;
   OSTEOPOROSIS
AB Hypoxia-inducible factor (HIF)-1 alpha plays a critical role in coupling angiogenesis with osteogenesis during bone development and regeneration. Salidroside (SAL) has shown anti-hypoxic effects in vitro and in vivo. However, the possible roles of SAL in the prevention of hypoxia-induced osteoporosis have remained unknown. Two osteoblast cell lines, MG-63 and ROB, were employed to evaluate the effects of SAL on cell viability, apoptosis, differentiation and mineralization in vitro. Rats subjected to ovariectomy-induced bone loss were treated with SAL in vivo. Our results showed that pre-treatment with SAL markedly attenuated the hypoxia-induced reductions in cell viability, apoptosis, differentiation and mineralization. SAL down-regulated HIF-1 alpha expression and inhibited its translocation; however, SAL increased its transcriptional activity and, consequently, up-regulated vascular endothelial growth factor (VEGF). In vivo studies further demonstrated that SAL caused decreases in the mineral, alkaline phosphatase (ALP), and BGP concentrations in the blood of ovariectomized (OVX) rats. Moreover, SAL improved the trabecular bone microarchitecture and increased bone mineral density in the distal femur. Additionally, SAL administration partially ameliorated this hypoxia via the HIF-1 alpha-VEGF signalling pathway. Our results indicate that SAL prevents bone loss by enhancing angiogenesis and osteogenesis and that these effects are associated with the activation of HIF-1 alpha signalling.
C1 [Li, Ling; Wang, Yue; Li, Ling Zhi] Tianjin Key Lab Prevent & Control Occupat & Envir, Tianjin, Peoples R China.
   [Li, Ling; Jin, Xin] Logist Coll Chinese Peoples Armed Police Forces, Dept Pharmacol, Tianjin, Peoples R China.
   [Qu, Ye; Guo, Xiao Qin; Wang, Yue; Qi, Lin; Yang, Jing] Logist Coll Chinese Peoples Armed Police Forces, Dept Pathogen Biol & Immunol, Tianjin, Peoples R China.
   [Zhang, Peng] Affiliated Hosp Logist Coll Chinese Peoples Armed, Dept Orthopaed, Tianjin, Peoples R China.
   [Li, Ling Zhi] Logist Coll Chinese Peoples Armed Police Forces, Dept Pharmaceut Chem, Tianjin, Peoples R China.
RP Wang, Y; Li, LZ (corresponding author), Tianjin Key Lab Prevent & Control Occupat & Envir, Tianjin, Peoples R China.; Wang, Y (corresponding author), Logist Coll Chinese Peoples Armed Police Forces, Dept Pathogen Biol & Immunol, Tianjin, Peoples R China.; Li, LZ (corresponding author), Logist Coll Chinese Peoples Armed Police Forces, Dept Pharmaceut Chem, Tianjin, Peoples R China.
EM wangyue6808@126.com; 13682196000@163.com
RI Guo, Xiaoqin/OHU-6833-2025; Li, Lingzhi/K-9055-2016
FU National Natural Science Foundation of China [81273520, 81572852,
   81471823, 81502256]; Programme of the Science Foundation of Tianjin
   [12JCZDJC26300, 15JCYBJC28900, 12JCZDJC34700]; Great Programme for
   Science and Technology in Logistics College of Chinese People's Armed
   Police Forces [WHZ201202, WHTD201303, WHB201404, WHB201405, WHB201406,
   WHB201505, WHJ201509]
FX This work was supported by grants from the National Natural Science
   Foundation of China (Nos 81273520, 81572852, 81471823 and 81502256), the
   Programme of the Science Foundation of Tianjin (Nos 12JCZDJC26300,
   15JCYBJC28900 and 12JCZDJC34700) and the Great Programme for Science and
   Technology in Logistics College of Chinese People's Armed Police Forces
   (Nos WHZ201202, WHTD201303, WHB201404, WHB201405, WHB201406, WHB201505
   and WHJ201509).
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NR 66
TC 40
Z9 51
U1 1
U2 51
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD AUG 25
PY 2016
VL 6
AR 32131
DI 10.1038/srep32131
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA DU0BE
UT WOS:000381865500001
PM 27558909
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wang, S
   Huayu, MD
   Su, SS
   Nan, XM
   Zhang, DJ
   Lu, DX
   Li, ZQ
AF Wang, Shan
   Huayu, Meiduo
   Su, Shanshan
   Nan, Xingmei
   Zhang, Dejun
   Lu, Dianxiang
   Li, Zhanqiang
TI ARGINASE INHIBITORY PROPERTIES OF PHENOLIC COMPOUNDS FROM RHODIOLA
   TANGUTICA
SO ACTA POLONIAE PHARMACEUTICA
LA English
DT Article
DE Rhodiola tangutica; phenolic; active ingredients; arginase inhibitors;
   enzyme kinetics
ID SMOOTH-MUSCLE CELLS; L-ARGININE; PULMONARY; HYPERTENSION; EXPRESSION;
   POLYAMINE; ALGIDA
AB Rhodiola tangutica (Maxim.) S. H. Fu is a traditional Tibetan herb growing on the Tibetan plateau at an altitude of 3000-4500 meters. The medicinal value of this plant is mainly concentrated in the roots and rhizomes containing its bioactive compounds, which have important developmental value. In course of the study of plant bioactivity, we conducted a screening of arginase inhibitors. The results showed that the alcoholic extract of R. tangutica with vasodilatory effect inhibited arginase at the highest rate of 48.22 +/- 6.69%, and that 14 of the 22 main chemical components of the active site inhibited arginase at a rate greater than 20%, while the positive control group inhibited caffeic acid by 61.68 +/- 6.65%. Based on this, we screened five new arginase inhibitors from the active site of R. tangutica, including salidroside, p-coumaric acid, rhodiosin, eriodictyol, and ethyl gallate, with IC50 values of 15.34, 127.5, 21.98, 62.45 mu M and > 200 mu M, respectively. In the enzyme kinetic experiments, the Ki'/Ki of the five compounds p-coumaric acid, salidroside, rhodiosin, ethyl gallate, and eriodictyol were 0.64, 10.08, 18.50, 0.72, and 1.46, respectively, indicating that their mechanisms of action on arginase were all mixed competitive inhibition type.
C1 [Wang, Shan; Huayu, Meiduo; Lu, Dianxiang; Li, Zhanqiang] Qinghai Univ, Key Lab Applicat & Fdn High Altitude Med Res Qing, Minist Educ,Qinghai Utah Joint Res Key Lab High A, Res Ctr High Altitude Med,Key Lab High Altitude M, Xining 810001, Qinghai, Peoples R China.
   [Wang, Shan; Zhang, Dejun] Qinghai Univ, Sch Ecol & Environm Engn, Xining 810016, Peoples R China.
   [Su, Shanshan] Xining Customs Tech Ctr, Key Lab Food Safety Res Qinghai Prov, Xining 810003, Qinghai, Peoples R China.
   [Nan, Xingmei] Qinghai Univ, Med Coll, Xining 810001, Peoples R China.
C3 Qinghai University; Qinghai University; Qinghai University
RP Li, ZQ (corresponding author), Qinghai Univ, Key Lab Applicat & Fdn High Altitude Med Res Qing, Minist Educ,Qinghai Utah Joint Res Key Lab High A, Res Ctr High Altitude Med,Key Lab High Altitude M, Xining 810001, Qinghai, Peoples R China.
EM zhanqiang_li@163.com
FU National Natural Science Foundation of China [81860768, 32060088];
   Natural Science Foundation for Young Scientists of Science and
   Technology Department in Qinghai province, China [2020-ZJ-950Q]; Qinghai
   Province "Kunlun Talents, High-end Innovative and Entrepreneurial
   Talents" Project; West Light Foundation of The Chinese Academy of
   Sciences
FX This work was supported by the National Natural Science Foundation of
   China (81860768 and 32060088), West Light Foundation of The Chinese
   Academy of Sciences, Natural Science Foundation for Young Scientists of
   Science and Technology Department in Qinghai province, China
   (2020-ZJ-950Q), Qinghai Province "Kunlun Talents, High-end Innovative
   and Entrepreneurial Talents" Project.
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NR 31
TC 1
Z9 1
U1 0
U2 11
PU POLSKIE TOWARZYSTWO FARMACEUTYCZNE
PI WARSAW
PA DLUGA 16, 00-238 WARSAW, POLAND
SN 0001-6837
EI 2353-5288
J9 ACTA POL PHARM
JI ACTA POL. PHARM.
PD MAR-APR
PY 2022
VL 79
IS 2
BP 223
EP 229
DI 10.32383/appdr/149835
PG 7
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 2G8DE
UT WOS:000813817600007
OA gold
DA 2026-05-27
ER

PT J
AU Chen, SS
   Cai, F
   Wang, JR
   Yang, ZX
   Gu, C
   Wang, GF
   Mao, GX
   Yan, J
AF Chen, Shasha
   Cai, Feng
   Wang, Jirong
   Yang, Zhouxin
   Gu, Chi
   Wang, Guofu
   Mao, Genxiang
   Yan, Jing
TI Salidroside protects SH-SY5Y from pathogenic α-synuclein by promoting
   cell autophagy via mediation of mTOR/p70S6K signaling
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE SAL; alpha-syn; PD; autophagy; mTOR
ID PARKINSONS-DISEASE; INCLUSION FORMATION; DEGRADATION; TRANSMISSION;
   CLEARANCE; APOPTOSIS; PATHOLOGY
AB The abnormal aggregation of alpha-synuclein (alpha-syn), which is an important pathological feature of Parkinson's disease (PD), is cytotoxic to dopaminergic neurons and causes cellular damage and apoptosis. Salidroside (SAL) is the main active component of the traditional Chinese medicine Rhodiola rosea. Previous research has demonstrated that SAL exerts cellular protection against cell senescence and neurodegeneration. However, the role and mechanism of action of SAL in PD remain unclear. The present study used overexpression of the wild-type and the A53T mutation of alpha-syn to induce a neuronal model of PD in SH-SY5Y cells, which led to neuronal toxicity and a reduced cell proliferation index. SAL increased the cell proliferation index of both PD model groups in a dose-dependent manner. Additionally, SAL alleviated pathogenic phosphorylated (Ser129) alpha-syn expression as well as the ratio of microtubule-associated proteins 1A/1B light chain 3 (LC3)-I to LC3-II expression, which is related to autophagic function. Furthermore, the results suggested that the underlying mechanism for the SAL-induced protection of PD model neurons may involve the preservation of autophagy, which attenuates the phosphorylation of alpha-syn in neurons predominantly via mTOR/p70S6K, and is independent of the PI3K/Akt signaling pathway.
C1 [Chen, Shasha; Wang, Jirong; Yang, Zhouxin; Wang, Guofu; Mao, Genxiang; Yan, Jing] Zhejiang Hosp, Dept Geriatr, Zhejiang Prov Key Lab Geriatr, 12 Lingyin Rd, Hangzhou 310013, Zhejiang, Peoples R China.
   [Cai, Feng; Gu, Chi] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurosurg, Hangzhou 310009, Zhejiang, Peoples R China.
C3 Zhejiang University
RP Mao, GX; Yan, J (corresponding author), Zhejiang Hosp, Dept Geriatr, Zhejiang Prov Key Lab Geriatr, 12 Lingyin Rd, Hangzhou 310013, Zhejiang, Peoples R China.
EM maodashi_176yeah@126.com; zjicu@vip.163.com
FU National Natural Science Foundation of China [81501113, 81502321,
   81771520]; Medical and Health Research Project of Zhejiang Province
   [2015KYA001, 2017KY188, 2014KYA089, 2014KYA093]
FX This work was supported by the National Natural Science Foundation of
   China (grant nos. 81501113, 81502321 and 81771520), and funds from the
   Medical and Health Research Project of Zhejiang Province (grant nos.
   2015KYA001, 2017KY188, 2014KYA089 and 2014KYA093).
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NR 42
TC 24
Z9 25
U1 0
U2 20
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD JUL
PY 2019
VL 20
IS 1
BP 529
EP 538
DI 10.3892/mmr.2019.10285
PG 10
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA II0DR
UT WOS:000474876100056
PM 31180515
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Yang, B
   Xu, Y
   Yu, JZ
   Wang, QH
   Fan, QG
   Zhao, XY
   Qiao, Y
   Zhang, ZY
   Zhou, Q
   Yin, D
   He, M
   He, H
AF Yang, Bin
   Xu, Ying
   Yu, Jingzhi
   Wang, Qihao
   Fan, Qigui
   Zhao, Xiaoyu
   Qiao, Yang
   Zhang, Zeyu
   Zhou, Qing
   Yin, Dong
   He, Ming
   He, Huan
TI Salidroside pretreatment alleviates ferroptosis induced by myocardial
   ischemia/reperfusion through mitochondrial superoxide-dependent AMPK α 2
   activation
SO PHYTOMEDICINE
LA English
DT Article
DE Salidroside; AMP-Activated protein kinase alpha 2; Myocardial
   ischemia-reperfusion injury; Ferroptosis; Mitochondria
ID REPERFUSION; INJURY; MECHANISMS; IRON; ROS
AB Background: Ferroptosis, a form of regulated cell death (RCD) that relies on excessive reactive oxygen species (ROS) generation, Fe 2 + accumulation, abnormal lipid metabolism and is involved in various organ ischemia/ reperfusion (I/R) injury, expecially in myocardium. Mitochondria are the powerhouses of eukaryotic cells and essential in regulating multiple RCD. However, the links between mitochondria and ferroptosis are still poorly understood. Salidroside (Sal), a natural phenylpropanoid glycoside isolated from Rhodiola rosea , has multbioactivities. However, the effects and mechanism in alleviating ferroptosis caused by myocardial I/R injury remains unclear. Purpose: This study aimed to investigate whether pretreated with Sal could protect the myocardium against I/R damage and the underlying mechanisms. In particular, the relationship between Sal pretreatment, AMPK alpha 2 activity, mitochondria and ROS generation was explored. Study design and methods: Firstly, A/R or I/R injury models were employed in H9c2 cells and Sprague-Dawley rats. And then the anti-ferroptotic effects and mechanism of Sal pretreatment was detected using multirelevant indexes in H9c2 cells. Further, how does Sal pretreatment in AMPK alpha 2 phosphorylation was explored. Finally, these results were validated by I/R injury in rats. Results: Similar to Ferrostatin-1 (a ferroptosis inhibitor) and MitoTEMPO, a mitochondrial free radical scavenger, Sal pretreatment effectively alleviated Fe 2 + accumulation, redox disequilibrium and maintained mitochondrial energy production and function in I/R-induced myocardial injury, as demonstrated using multifunctional, enzymatic, and morphological indices. However, these effects were abolished by downregulation of AMPK alpha 2 using an adenovirus, both in vivo and in vitro . Moreover, the results also provided a non -canonical mechanism that, under mild mitochondrial ROS generation, Sal pretreatment upregulated and phosphorylated AMPK alpha 2, which enhanced mitochondrial complex I activity to activate innate adaptive responses and increase cellular tolerance to A/R injury. Conclusion: Overall, our work highlighted mitochondria are of great impotance in myocardial I/R-induced ferroptosis and demonstrated that Sal pretreatment activated AMPK alpha 2 against I/R injury, indicating that Sal could become a candidate phytochemical for the treatment of myocardial I/R injury.
C1 [Yang, Bin; Xu, Ying; Yu, Jingzhi; Wang, Qihao; Fan, Qigui; Zhao, Xiaoyu; Zhou, Qing; Yin, Dong; He, Ming; He, Huan] Nanchang Univ, Sch Pharmaceut Sci, Jiangxi Prov Key Lab Basic Pharmacol, 461 Bayi Rd, Nanchang 330006, Peoples R China.
   [Qiao, Yang; Zhang, Zeyu] Nanchang Univ, Affiliated Hosp 1, Jiangxi Acad Clin Med Sci, Nanchang 330006, Peoples R China.
C3 Nanchang University; Nanchang University
RP He, M; He, H (corresponding author), Nanchang Univ, Sch Pharmaceut Sci, Jiangxi Prov Key Lab Basic Pharmacol, 461 Bayi Rd, Nanchang 330006, Peoples R China.
EM jxhm56@hotmail.com; hehuan0118@ncu.edu.cn
RI Qiao, Yang/PNI-7663-2026; He, Huan/IAQ-9942-2023
FU National Natural Science Foun-dation of China [82160685, 82360142,
   81803534]; Jiangxi Province Ganpo Juncai Support Plan for Young Talents
   [20232BCJ23041]
FX Funding This research was supported by the National Natural Science
   Foun-dation of China (82160685, 82360142, 81803534) and Jiangxi Province
   Ganpo Juncai Support Plan for Young Talents (20232BCJ23041) .
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NR 30
TC 35
Z9 41
U1 4
U2 22
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUN
PY 2024
VL 128
AR 155365
DI 10.1016/j.phymed.2024.155365
EA MAR 2024
PG 21
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA RG3M5
UT WOS:001226474700001
PM 38552436
OA hybrid
DA 2026-05-27
ER

PT J
AU Li, LP
   Fu, WL
   Wang, J
   Zhang, S
   Liu, WY
AF Li, Leping
   Fu, Wenli
   Wang, Juan
   Zhang, Sha
   Liu, Weiying
TI Salidroside Improves Cellular Senescence in COPD by Inhibiting the
   JAK2/STAT3 Pathway
SO JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS
LA English
DT Article
DE salidroside; JAK2; STAT3; cellular senescence
ID OXIDATIVE STRESS; RAT PLASMA; ACTIVATION; DISEASE
AB Background: Chronic obstructive pulmonary disease (COPD) is a respiratory illness, with cellular senescence recognized as an essential mechanism driving this chronic lung disease. Salidroside (Sal), a natural compound, is recognized for its anti-aging impacts. Therefore, this study aims to investigate the role and the underlying mechanism of Sal on airway epithelial cell senescence. Methods: In vitro experiments were performed by treating BEAS-2B cells with cigarette smoke extract (CSE), AG490 (Janus kinase 2 (JAK2) inhibitor), or Sal (40 mu M, 80 mu M, 160 mu M). Moreover, senescence-associated beta-galactosidase (SA-beta-gal) staining and the manifestation of senescence-related genes were used to assess cellular senescence. The mRNA levels of cyclin-dependent kinase inhibitor 2a (p16) and cyclin-dependent kinase inhibitor 1a (p21) were evaluated. Furthermore, Western blot analysis was employed to determine the expression levels of p16, p21, Janus kinase 2 (JAK2), phosphorylated-JAK2 (p-JAK2), signal transducer and activator of transcription 3 (STAT3), and phosphorylated-STAT3 (p-STAT3). Additionally, the cytokine levels associated with the senescence-associated secretory phenotype (SASP) were evaluated utilizing corresponding enzyme-linked immunosorbent assay kits. Results: In vitro, cellular experiments demonstrated that Human bronchial epithelial cells underwent senescence in response to CSE, as evidenced by elevated expression of p16 (p < 0.05) and p21 (p < 0.05), and promotion of senescence-associated secretory phenotype (SASP), as well as up-regulation of JAK2/STAT3 signaling pathway activity. AG490 treatment significantly ameliorated CSE-induced cellular senescence, resulting in down-regulation of the JKA2/STAT3 signaling pathway, alleviation of the senescence molecules p16 (p < 0.05), p21 (p < 0.05), p-JKA2 (p < 0.01) and p-STAT3 (p < 0.05). The inhibitor decreased the secretion of SASP cytokines, and decreased the activity of SA-beta-gal. Additionally, Sal reduced p16 (p < 0.01) and p21 (p < 0.05) expression, potentially reversed CSE-induced cellular senescence, and inhibited the JAK2/STAT3 signaling pathway, as well as decreased SASP secretion and SA-beta-gal activity. Conclusion: Sal reduces CSE-induced BEAS-2B cellular senescence by inhibiting the JAK2/STAT3 signaling pathway, providing a novel strategy for COPD treatment.
C1 [Li, Leping; Fu, Wenli; Wang, Juan; Zhang, Sha] Lanzhou Univ, Clin Med Coll 1, Dept Resp Med, Lanzhou 730000, Gansu, Peoples R China.
   [Liu, Weiying] Lanzhou Univ, Hosp 1, Dept Resp & Crit Care Med, Lanzhou 730000, Gansu, Peoples R China.
C3 Lanzhou University; Lanzhou University
RP Liu, WY (corresponding author), Lanzhou Univ, Hosp 1, Dept Resp & Crit Care Med, Lanzhou 730000, Gansu, Peoples R China.
EM lwy70828@126.com
RI Weiying, Liu/GXV-3892-2022
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NR 58
TC 0
Z9 1
U1 3
U2 17
PU BIOLIFE SAS
PI SILVA MARINA (TE)
PA VIA S STEFANO 39 BIS, 64029 SILVA MARINA (TE), ITALY
SN 0393-974X
EI 1724-6083
J9 J BIOL REG HOMEOS AG
JI J. Biol. Regul. Homeost. Agents
PD MAY
PY 2024
VL 38
IS 5
BP 4415
EP 4426
DI 10.23812/j.biol.regul.homeost.agents.20243805.351
PG 12
WC Endocrinology & Metabolism; Immunology; Medicine, Research &
   Experimental; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Endocrinology & Metabolism; Immunology; Research & Experimental
   Medicine; Physiology
GA RF8V8
UT WOS:001226353400001
OA hybrid
DA 2026-05-27
ER

PT J
AU Javid, A
   Gampe, N
   Gelana, F
   György, Z
AF Javid, Aaqib
   Gampe, Nora
   Gelana, Fulea
   Gyorgy, Zsuzsanna
TI Enhancing the Accumulation of Rosavins in Rhodiola rosea L.
   Plants Grown In Vitro by Precursor Feeding
SO AGRONOMY-BASEL
LA English
DT Article
DE biotransformation; cinnamyl alcohol glycosides; HPLC; precursor feeding;
   roseroot
ID CINNAMYL ALCOHOL; CALLUS; SALIDROSIDE; BIOTRANSFORMATION; GLYCOSIDES;
   CULTURES; IDENTIFICATION
AB Rhodiola rosea produces nearly 150 bioactive compounds. Cinnamyl alcohol glycosides (CAGs) are among the most important secondary metabolites which are specific to this plant species, exhibiting adaptogenic properties along with salidroside. However, raw material supplies for the pharmaceutical industry are hindered by limited access to the plant material. The species is endangered and protected in many areas: cultivation is long and ineffective. Precursor feeding has been found to be an effective strategy for improving the production of secondary metabolites in various plant tissues cultures, including in Rhodiola species. In this study, whole R. rosea plants grown in vitro were subjected to three different precursor treatments, including with trans-cinnamic acid, cinnamaldehyde and cinnamyl alcohol at 2 mM concentrations. The different treatments affected the secondary metabolite production differently. Trans-cinnamic acid did not affect the synthesis significantly, which contradicts earlier studies with cell suspensions. On the other hand, cinnamyl alcohol and cinnamaldehyde were beneficial, improving the production rate of rosin and rosavin by 13.8- and 6.9-fold, and 92.7- and 8.0-fold, respectively. The significant improvement in CAG accumulation due to cinnamaldehyde treatment was unexpected based on previous studies. In addition, cinnamaldehyde triggered the production of rosarin, which the other two treatments failed to do. The study presents the beneficial application of precursors to whole plants grown in vitro.
C1 [Javid, Aaqib; Gelana, Fulea; Gyorgy, Zsuzsanna] Hungarian Univ Agr & Life Sci, Inst Genet & Biotechnol, Dept Plant Biotechnol, H-1118 Budapest, Hungary.
   [Gampe, Nora] Semmelweis Univ, Dept Pharmacognosy, H-1085 Budapest, Hungary.
C3 Hungarian University of Agriculture & Life Sciences; Semmelweis
   University
RP György, Z (corresponding author), Hungarian Univ Agr & Life Sci, Inst Genet & Biotechnol, Dept Plant Biotechnol, H-1118 Budapest, Hungary.
EM mir.aaqib123@gmail.com; gampe.nora@gmail.com; fula2012@gmail.com;
   gyorgy.zsuzsanna@gmail.com
RI Gampe, Nóra/E-6421-2017; György, Zsuzsanna/L-7105-2016
OI Gampe, Nóra/0000-0001-7208-9372; György, Zsuzsanna/0000-0002-7803-5487;
   Javid, Aaqib/0000-0002-3484-686X
FU National Research, Development, and Innovation Office of Hungary
   [FK128793]
FX FundingThis study was financed by the National Research, Development,
   and Innovation Office of Hungary (FK128793).
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NR 31
TC 9
Z9 9
U1 3
U2 13
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 2073-4395
J9 AGRONOMY-BASEL
JI Agronomy-Basel
PD DEC
PY 2021
VL 11
IS 12
AR 2531
DI 10.3390/agronomy11122531
PG 9
WC Agronomy; Plant Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Plant Sciences
GA XV9BS
UT WOS:000735228700001
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, W
   He, H
   Song, HJ
   Zhao, JJ
   Li, T
   Wu, LT
   Zhang, XJ
   Chen, JZ
AF Zhang, Wei
   He, Hong
   Song, Hujie
   Zhao, Junjie
   Li, Tao
   Wu, Leitao
   Zhang, Xiaojun
   Chen, Jianzong
TI Neuroprotective Effects of Salidroside in the MPTP Mouse Model of
   Parkinson's Disease: Involvement of the PI3K/Akt/GSK3β Pathway
SO PARKINSONS DISEASE
LA English
DT Article
ID GLYCOGEN-SYNTHASE KINASE-3-BETA; OXIDATIVE STRESS; PC12 CELLS; INDUCED
   APOPTOSIS; SUBSTANTIA-NIGRA; TIME-COURSE; DOPAMINE; NEURONS; KINASE;
   ACTIVATION
AB The degenerative loss through apoptosis of dopaminergic neurons in the substantia nigra pars compacta plays a primary role in the progression of Parkinson's disease (PD). Our in vitro experiments suggested that salidroside (Sal) could protect against 1methyl- 4-phenylpyridine-induced cell apoptosis in part by regulating the PI3K/Akt/GSK3 beta pathway. The current study aims to increase our understanding of the protective mechanisms of Sal in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine-(MPTP) induced PD mouse model. We found that pretreatment with Sal could protect against MPTP-induced increase of the time of turning downwards and climbing down to the floor. Sal also prevented MPTP-induced decrease of locomotion frequency and the increase of the immobile time. Sal provided a protection of in MPTP-induced loss of tyrosine hydroxylase-positive neurons in SNpc and the level of DA, DOPAC, and HVA in the striatum. Furthermore, Sal could increase the phosphorylation level of Akt and GSK3 beta, upregulate the ratio of Bcl-2/Bax, and inhibit the activation of caspase-3, caspase-6, and caspase-9. These results show that Sal prevents the loss of dopaminergic neurons and the PI3K/Akt/GSK3 beta pathway signaling pathway may have mediated the protection of Sal against MPTP, suggesting that Sal may be a potential candidate in neuroprotective treatment for PD.
C1 [Zhang, Wei; He, Hong; Zhao, Junjie; Li, Tao; Wu, Leitao; Chen, Jianzong] Fourth Mil Med Univ, Xijing Hosp, Res Ctr Tradit Chinese Med, Xian 710032, Peoples R China.
   [Song, Hujie] Xian Encephalopathy Hosp Tradit Chinese Med, Dept Encephalopathy, Xian 710032, Peoples R China.
   [Zhang, Xiaojun] Fourth Mil Med Univ, Dept Phys, Xian 710032, Peoples R China.
C3 Air Force Medical University; Air Force Medical University
RP Chen, JZ (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Res Ctr Tradit Chinese Med, Xian 710032, Peoples R China.; Zhang, XJ (corresponding author), Fourth Mil Med Univ, Dept Phys, Xian 710032, Peoples R China.
EM zy04310@fmmu.edu.cn; jzchen57@fmmu.edu.cn
RI ; Li, Tao/LJM-1988-2024; Zhao, Junjie/OTI-3022-2025
OI Zhang, Xiaojun/0000-0002-0304-0003; 
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NR 55
TC 35
Z9 39
U1 0
U2 14
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 2090-8083
EI 2042-0080
J9 PARKINSONS DIS-US
JI Parkinsons Dis.
PY 2016
VL 2016
AR 9450137
DI 10.1155/2016/9450137
PG 9
WC Clinical Neurology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DY5MJ
UT WOS:000385143600001
PM 27738547
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, DJ
   Sun, LL
   Li, HF
   Cui, YL
   Liu, S
   Wu, P
   Zhao, DS
   Zhao, P
   Zhang, XL
AF Zhang, Danjie
   Sun, Linlin
   Li, Huifen
   Cui, Yueli
   Liu, Shuai
   Wu, Peng
   Zhao, Dongsheng
   Zhao, Pan
   Zhang, Xuelan
TI Pharmacokinetic comparison of nine bioactive components in rat plasma
   following oral administration of raw and wine-processed Ligustri Lucidi
   Fructus by ultra-high-performance liquid chromatography coupled with
   triple quadrupole mass spectrometry
SO JOURNAL OF SEPARATION SCIENCE
LA English
DT Article
DE Ligustri Lucidi Fructus; mass spectrometry; pharmacokinetics;
   traditional Chinese medicine; wine-processing
ID TRADITIONAL CHINESE MEDICINE; SALIDROSIDE
AB An accurate and sensitive ultra-high-performance liquid chromatography coupled with triple quadrupole mass spectrometry method was established and validated for the determination of nine bioactive compounds of Ligustri Lucidi Fructus in rat plasma. Separation was performed on Halo(R)C(18)column with a mobile phase of acetonitrile and 0.1% formic acid in water. The eluate was detected by multiple reaction monitoring scanning operating in the negative ionization mode. This assay method was validated for selectivity, linearity, intra- and interday precision, accuracy, recovery, matrix effect, and stability, and all methodological parameters fulfilled the Food and Drug Administration criteria for bioanalytical validation. The established method was successfully applied to a comparative pharmacokinetic study of raw and wine-processed Ligustri Lucidi Fructus in rats for the first time. It was found that the AUC(0-24)andC(max)value of salidroside, hydroxytyrosol, and nuezhenidic acid were increased significantly after processing, while the AUC(0-24)andC(max)value of oleoside 11-methyl ester, 1 '''-O-beta-d-glucosylformoside, specnuezhenide, G13, oleonuezhenide, and oleanolic acid were decreased, which suggested that processing affects the absorption and bioavailability of Ligustri Lucidi Fructus. The results might be valuable for the clinical reasonable application and understanding the processing mechanism of Ligustri Lucidi Fructus.
C1 [Zhang, Danjie; Li, Huifen; Cui, Yueli; Wu, Peng; Zhao, Dongsheng; Zhao, Pan; Zhang, Xuelan] Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China.
   [Sun, Linlin] Shandong Univ Tradit Chinese Med, Expt Ctr, Jinan, Peoples R China.
   [Liu, Shuai] Ocean Univ China, Coll Pharm, Qingdao, Peoples R China.
   [Zhang, Xuelan] Shandong Prov Collaborat Innovat Ctr, Qual Control & Construct Whole Ind Chain Tradit C, Jinan, Peoples R China.
C3 Shandong University of Traditional Chinese Medicine; Shandong University
   of Traditional Chinese Medicine; Ocean University of China
RP Zhao, P; Zhang, XL (corresponding author), Shandong Univ Tradit Chinese Med, Coll Pharm, Jinan 250355, Peoples R China.
EM zhao.pan.pan@163.com; zhang8832440@sina.com
RI zhang, danjie/GVT-8387-2022; zhao, Dong-Sheng/H-9309-2016
OI zhang, danjie/0000-0003-3968-0835; 
FU National Natural Science Foundation of China [81973486, 81573606,
   81903780]; Youth Science Foundation of Shandong University of
   Traditional Chinese Medicine [2018zk04]; Traditional Chinese Medicine
   Science and Technology Development Plan of Shandong Province [2019-0030]
FX This work was financially supported by the National Natural Science
   Foundation of China (Nos. 81973486, 81573606, and 81903780); Youth
   Science Foundation of Shandong University of Traditional Chinese
   Medicine (No. 2018zk04); and Project Funded by the Traditional Chinese
   Medicine Science and Technology Development Plan of Shandong Province
   (2019-0030).
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NR 30
TC 9
Z9 15
U1 1
U2 36
PU WILEY-V C H VERLAG GMBH
PI WEINHEIM
PA POSTFACH 101161, 69451 WEINHEIM, GERMANY
SN 1615-9306
EI 1615-9314
J9 J SEP SCI
JI J. Sep. Sci.
PD NOV
PY 2020
VL 43
IS 21
BP 3995
EP 4005
DI 10.1002/jssc.202000625
EA OCT 2020
PG 11
WC Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA OL5QX
UT WOS:000574132500001
PM 32864882
DA 2026-05-27
ER

PT J
AU Lee, SY
   Shi, LS
   Chu, H
   Li, MH
   Ho, CW
   Lai, FY
   Huang, CY
   Chang, TC
AF Lee, Shih-Yu
   Shi, Li-Shian
   Chu, Hsin
   Li, Min-Hui
   Ho, Cheng-Wen
   Lai, Feng-Yi
   Huang, Chih-Yang
   Chang, Tsu-Chung
TI Rhodiola crenulata and Its Bioactive Components, Salidroside and
   Tyrosol, Reverse the Hypoxia-Induced Reduction of
   Plasma-Membrane-Associated Na,K-ATPase Expression via Inhibition of
   ROS-AMPK-PKCξ Pathway
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID K-ATPASE; MUSCLE-CELLS; ALVEOLAR; NA; TRANSPORT; ENDOCYTOSIS;
   EPITHELIUM; DECREASE; SODIUM; CANCER
AB Exposure to hypoxia leads to impaired pulmonary sodium transport, which is associated with Na,K-ATPase dysfunction in the alveolar epithelium. The present study is designed to examine the effect and mechanism of Rhodiola crenulata extract (RCE) and its bioactive components on hypoxia-mediated Na,K-ATPase endocytosis. A549 cells were exposed to hypoxia in the presence or absence of RCE, salidroside, or tyrosol. The generation of intracellular ROS was measured by using the fluorescent probe DCFH-DA, and the endocytosis was determined by measuring the expression level of Na,K-ATPase in the PM fraction. Rats exposed to a hypobaric hypoxia chamber were used to investigate the efficacy and underlying mechanism of RCE in vivo. Our results showed that RCE and its bioactive compounds significantly prevented the hypoxia-mediated endocytosis of Na,K-ATPase via the inhibition of the ROS-AMPK-PKC zeta pathway in A549 cells. Furthermore, RCE also showed a comparable preventive effect on the reduction of Na,K-ATPase endocytosis and inhibition of AMPK-PKC xi pathway in the rodent model. Our study is the first to offer substantial evidence to support the efficacy of Rhodiola products against hypoxia-associated Na,K-ATPase endocytosis and clarify the ethnopharmacological relevance of Rhodiola crenulata as a popular folk medicine for high-altitude illness.
C1 [Lee, Shih-Yu; Chang, Tsu-Chung] Natl Def Med Ctr, Grad Inst Med Sci, Taipei 114, Taiwan.
   [Lee, Shih-Yu; Chu, Hsin; Li, Min-Hui; Ho, Cheng-Wen] Natl Def Med Ctr, Inst Aerosp & Undersea Med, Taipei 114, Taiwan.
   [Shi, Li-Shian] Natl Formosa Univ, Dept Biotechnol, Yunlin 632, Taiwan.
   [Lai, Feng-Yi; Chang, Tsu-Chung] Natl Def Med Ctr, Dept Biochem, Taipei 114, Taiwan.
   [Huang, Chih-Yang; Chang, Tsu-Chung] Asia Univ, Dept Hlth & Nutr Biotechnol, Taichung 413, Taiwan.
   [Huang, Chih-Yang; Chang, Tsu-Chung] China Med Univ, Grad Inst Basic Med Sci, Taichung 400, Taiwan.
C3 National Defense Medical University; National Defense Medical
   University; National Formosa University; National Defense Medical
   University; Asia University Taiwan; China Medical University Taiwan
RP Chang, TC (corresponding author), Natl Def Med Ctr, Grad Inst Med Sci, Taipei 114, Taiwan.
EM tcchang@ndmctsgh.edu.tw
RI Lee, Shih-Yu/AAO-4110-2020; Huang, Chih-Yang/Q-4862-2016
OI Lee, Shih-Yu/0000-0002-4713-6410; Huang, Chih-Yang/0000-0003-2347-0411
FU National Science Council [NSC 100-2320-B-016-007-, NSC
   101-2320-B-016-010-MY2]; Ministry of National Defense, Taipei, Taiwan,
   ROC [DOD-101-14-5, DOD-101-93]
FX This work was supported by Grants from the National Science Council (NSC
   100-2320-B-016-007- and NSC 101-2320-B-016-010-MY2 to Tsu-Chung Chang)
   and the Ministry of National Defense (DOD-101-14-5 to Tsu-Chung Chang
   and DOD-101-93 to Shih-Yu Lee), Taipei, Taiwan, ROC. The authors also
   thank Professor Daniel Steve Villarreal, Ph.D., Center for General
   Education, National Defense Medical Center, Taipei, Taiwan for the
   English editing.
CR [Anonymous], EVID BASED COMPLEMEN
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NR 39
TC 53
Z9 59
U1 5
U2 16
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PY 2013
VL 2013
AR 284150
DI 10.1155/2013/284150
PG 15
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 166EL
UT WOS:000320537400001
PM 23840253
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Liu, MT
   Gu, YH
   Yang, YC
   Zhang, K
   Yang, JW
   Wang, WQ
   Li, WJ
   Wang, XZ
   Dong, XX
   Yin, XB
   Qu, CH
   Ni, BR
   Ni, J
AF Liu, Manting
   Gu, Yuhao
   Yang, Yuchang
   Zhang, Ke
   Yang, Jingwen
   Wang, Wenqi
   Li, Wenjing
   Wang, Xinzhu
   Dong, Xiaoxv
   Yin, Xingbin
   Qu, Changhai
   Ni, Boran
   Ni, Jian
TI Network Pharmacology, Molecular Dynamics Simulation, and Biological
   Validation Insights into the Potential of Ligustri Lucidi Fructus for
   Diabetic Nephropathy
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Ligustri Lucidi Fructus; diabetic nephropathy; network pharmacology;
   molecular docking; molecular dynamics simulation; cGAS-STING
ID TRADITIONAL CHINESE MEDICINE; OXIDATIVE STRESS; HIGH GLUCOSE;
   KIDNEY-DISEASE; INFLAMMATION; ACID; SALIDROSIDE; EXPRESSION; MECHANISM;
   APIGENIN
AB Diabetic nephropathy (DN) represents a severe microvascular complication of diabetes mellitus. As a Traditional Chinese Medicine (TCM) with extensive clinical applications, Ligustri Lucidi Fructus (LLF) exhibits significant anti-DN activity. However, the underlying pharmacological mechanisms, crucial components, and targets for LLF in DN treatment remain unclear. By integrating network pharmacology, molecular docking, and molecular dynamics simulations, the bioactive compounds, potential therapeutic targets, and underlying mechanisms of LLF in the treatment of DN were elucidated, followed by biological validation in a palmitic acid (PA)-induced MPC5 podocyte injury model. Among the 383 DN-related LLF targets identified, TNF emerged as a pivotal one, demonstrating potential binding interaction with the active components salidroside (Sal), apigenin (Api), and tormentic acid (TA). Moreover, Gene Expression Omnibus (GEO) database and KEGG enrichment analysis collectively highlighted the cytosolic DNA-sensing pathway. Notably, the cGAS-STING pathway is central to this pathway. Experimental studies further demonstrated that LLF-containing serum exerted a protective effect on MPC5 podocytes through cGAS-STING pathway suppression. Overall, these findings elucidate the pleiotropic mechanisms underlying LLF's protective effects against DN, integrating compound-target-pathway interactions and thus offering a rationale for further investigation.
C1 [Liu, Manting; Gu, Yuhao; Yang, Yuchang; Zhang, Ke; Yang, Jingwen; Wang, Wenqi; Li, Wenjing; Wang, Xinzhu; Dong, Xiaoxv; Yin, Xingbin; Qu, Changhai; Ni, Jian] Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102401, Peoples R China.
   [Ni, Boran] China Acad Chinese Med Sci, Beijing 100700, Peoples R China.
C3 Beijing University of Chinese Medicine; China Academy of Chinese Medical
   Sciences
RP Ni, J (corresponding author), Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 102401, Peoples R China.; Ni, BR (corresponding author), China Acad Chinese Med Sci, Beijing 100700, Peoples R China.
EM 20230941503@bucm.edu.cn; 20220941456@bucm.edu.cn;
   20240941529@bucm.edu.cn; 20240935273@bucm.edu.cn;
   20240935160@bucm.edu.cn; 20240935097@bucm.edu.cn;
   20240935159@bucm.edu.cn; 20240935161@bucm.edu.cn; 201801020@bucm.edu.cn;
   yxbtcm@bucm.edu.cn; quchanghai@bucm.edu.cn; niboran4331@gamyy.cn;
   02054@bucm.edu.cn
RI yin, xingbin/PHF-5801-2026; Gu, Yuhao/HNI-0045-2023; Wang,
   Xinzhu/GZM-8231-2022; Qu, Changhai/JDC-6593-2023
OI yin, xingbin/0000-0003-3077-1626; 
FU National Administration of Traditional Chinese Medicine High level
   Construction Discipline;  [zyyzdxk-2023272]
FX This research was funded supported by National Administration of
   Traditional Chinese Medicine High level Construction Discipline (grant
   number zyyzdxk-2023272).
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NR 84
TC 7
Z9 7
U1 16
U2 31
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD JUN 30
PY 2025
VL 26
IS 13
AR 6303
DI 10.3390/ijms26136303
PG 24
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 4TQ4H
UT WOS:001526393700001
PM 40650083
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Tung, YT
   Wu, MF
   Lee, MC
   Wu, JH
   Huang, CC
   Huang, WC
AF Tung, Yu-Tang
   Wu, Ming-Fang
   Lee, Mon-Chien
   Wu, Jyh-Horng
   Huang, Chi-Chang
   Huang, Wen-Ching
TI Antifatigue Activity and Exercise Performance of Phenolic-Rich Extracts
   from Calendula officinalis, Ribes nigrum, and Vaccinium
   myrtillus
SO NUTRIENTS
LA English
DT Article
DE antifatigue activity; antioxidant; polyphenol; salidroside; exercise
   adaption
ID VITAMIN-C SUPPLEMENTATION; OXIDATIVE STRESS; EXHAUSTIVE EXERCISE; MUSCLE
   DAMAGE; QUERCETIN SUPPLEMENTATION; ANTIOXIDANT ACTIVITY; ECCENTRIC
   EXERCISE; PHYSICAL STAMINA; XANTHINE-OXIDASE; BODY-COMPOSITION
AB Calendula officinalis, Ribes nigrum, and Vaccinium myrtillus (CRV) possess a high phenolic compound content with excellent antioxidant activity. Dietary antioxidants can reduce exercise-induced oxidative stress. Consumption of large amounts of phenolic compounds is positively correlated with reduction in exercise-induced muscle damage. Research for natural products to improve exercise capacity, relieve fatigue, and accelerate fatigue alleviation is ongoing. Here, CRV containing a large total phenolic content (13.4 mg/g of CRV) demonstrated antioxidant activity. Ultra-performance liquid chromatography quantification revealed 1.95 +/- 0.02 mg of salidroside in 1 g of CRV. In the current study, CRV were administered to mice for five weeks, and the antifatigue effect of CRV was evaluated using the forelimb grip strength test; weight-loaded swimming test; and measurement of fatigue-related biochemical indicators, such as blood lactate, ammonia, glucose, blood urea nitrogen (BUN), and creatine kinase (CK) activity; and muscle and liver glycogen content. The results indicated that in CRV-treated mice, the forelimb grip strength significantly increased; weight-loaded swimming time prolonged; their lactate, ammonia, BUN, and CK activity decreased, and muscle and liver glucose and glycogen content increased compared with the vehicle group. Thus, CRV have antifatigue activity and can increase exercise tolerance.
C1 [Tung, Yu-Tang; Huang, Chi-Chang] Taipei Med Univ, Grad Inst Metab & Obes Sci, Taipei 11031, Taiwan.
   [Tung, Yu-Tang] Taipei Med Univ Hosp, Nutr Res Ctr, Taipei 11031, Taiwan.
   [Wu, Ming-Fang; Lee, Mon-Chien; Huang, Chi-Chang] Natl Taiwan Sport Univ, Grad Inst Sports Sci, Taoyuan 33301, Taiwan.
   [Wu, Jyh-Horng] Natl Chung Hsing Univ, Dept Forestry, Taichung 402, Taiwan.
   [Huang, Wen-Ching] Natl Taipei Univ Nursing & Hlth Sci, Dept Exercise & Hlth Sci, Taipei 11219, Taiwan.
C3 Taipei Medical University; Taipei Medical University; Taipei Medical
   University Hospital; National Taiwan Sport University; National Chung
   Hsing University; National Taipei University of Nursing & Health Science
   (NTUNHS)
RP Huang, CC (corresponding author), Taipei Med Univ, Grad Inst Metab & Obes Sci, Taipei 11031, Taiwan.; Huang, CC (corresponding author), Natl Taiwan Sport Univ, Grad Inst Sports Sci, Taoyuan 33301, Taiwan.; Huang, WC (corresponding author), Natl Taipei Univ Nursing & Hlth Sci, Dept Exercise & Hlth Sci, Taipei 11219, Taiwan.
EM john5523@ntsu.edu.tw; wenching@ntunhs.edu.tw
RI Huang, Chi-Chang/A-3280-2013; Wu, Jyh-Horng/AAE-7142-2020
OI Huang, Chi-Chang/0000-0003-1446-6787; Tung, Yu-Tang/0000-0002-4780-6496;
   Wu, Jyh-Horng/0000-0002-1187-1114
FU University-Industry Cooperation Fund of National Taiwan Sport
   University, Taoyuan, Taiwan [1061010]; Ministry of Science and
   Technology (MOST) of Taiwan; MOST [107-2410-H-227-007]
FX This study was funded in part by the University-Industry Cooperation
   Fund of National Taiwan Sport University, Taoyuan, Taiwan (No. 1061010)
   and in part by the Ministry of Science and Technology (MOST) of Taiwan
   (grant no. MOST 107-2410-H-227-007).
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NR 84
TC 30
Z9 37
U1 1
U2 71
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
EI 2072-6643
J9 NUTRIENTS
JI Nutrients
PD AUG
PY 2019
VL 11
IS 8
AR 1715
DI 10.3390/nu11081715
PG 16
WC Nutrition & Dietetics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Nutrition & Dietetics
GA IV8HH
UT WOS:000484506000174
PM 31349650
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Li, YK
   Zheng, HY
   Liang, YX
   Xuan, M
   Liu, GT
   Xie, HX
AF Li, Yike
   Zheng, Huiyu
   Liang, Yaxian
   Xuan, Ming
   Liu, Guiting
   Xie, Huixu
TI Hyaluronic acid-methacrylic anhydride/polyhexamethylene biguanide hybrid
   hydrogel with antibacterial and proangiogenic functions for diabetic
   wound repair
SO CHINESE CHEMICAL LETTERS
LA English
DT Article
DE Hydrogel; Diabetic wounds; Antibacterial; Angiogenesis
ID BURDEN
AB Diabetic wounds lead to a decrease in quality of life and an increase in mortality. Current treatment strategies include preventing bacterial adhesion while improving microcirculation. As a new type of wound dressing that imitates natural skin, hydrogel has gradually emerged with its excellent properties. However, existing hydrogels rarely achieve satisfactory results in promoting wound repair and antibacterial simultaneously. In this case, we prepared methacrylic anhydride chemically modified hyaluronic acid as a hydrogel matrix, added polyhexamethylene biguanide as an antibacterial component, and loaded sodium alginate/salidroside composite microspheres which could sustainably release salidroside and thus promote angiogenesis. Hybrid hydrogel (HAMA/PHMB-Ms) was synthesized via photocrosslinking, and its chemical structure, particle size distribution and microstructure were characterized. The satisfactory antibacterial properties of the HAMA/PHMB(15%)-Ms hydrogel were studied in vitro, and its antibacterial rates against E. coli and S. aureus were 97.85% and 98.56%, respectively. In addition, after demonstrating its good biocompatibility, we verified that the HAMA/PHMB-Ms hydrogel has increased granulation tissue formation, more collagen deposition, more subcutaneous capillary formation, and better wound healing than blank control, HAMA and HAMA/PHMB hydrogel on the back wound model of diabetic mice. The results confirmed that HAMA/PHMB-Ms hydrogel was a promising material for the treatment of the diabetic wounds. (c) 2022 Published by Elsevier B.V. on behalf of Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences.
C1 [Li, Yike; Zheng, Huiyu; Liang, Yaxian; Xuan, Ming; Liu, Guiting; Xie, Huixu] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis,State Key Lab Polymer Mat, Chengdu 610041, Peoples R China.
C3 Sichuan University
RP Liu, GT; Xie, HX (corresponding author), Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, State Key Lab Oral Dis,State Key Lab Polymer Mat, Chengdu 610041, Peoples R China.
EM liugt@scu.edu.cn; aitian007@126.com
RI Liu, Guiting/HKF-0265-2023
FU National Natural Science Foundation of China [52103039]; Medical Science
   and Technology Project of Sichuan Provincial Health Commission
   [21PJ059]; Science and Technology Application Fundamental Project of
   Sichuan Province [2019YJ0724]; Sichuan University Postdoctoral
   Interdisciplinary Innovation Fund
FX This work was supported by the National Natural Science Foundation of
   China (No. 52103039), Medical Science and Technology Project of Sichuan
   Provincial Health Commission (No. 21PJ059), Science and Technology
   Application Fundamental Project of Sichuan Province (No. 2019YJ0724),
   Sichuan University Postdoctoral Interdisciplinary Innovation Fund.
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TC 50
Z9 61
U1 13
U2 163
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 1001-8417
EI 1878-5964
J9 CHINESE CHEM LETT
JI Chin. Chem. Lett.
PD DEC
PY 2022
VL 33
IS 12
BP 5030
EP 5034
DI 10.1016/j.cclet.2022.03.116
EA JUL 2022
PG 5
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA 4L5OB
UT WOS:000852679000008
DA 2026-05-27
ER

PT J
AU Nabavi, SF
   Braidy, N
   Orhan, IE
   Badiee, A
   Daglia, M
   Nabavi, SM
AF Nabavi, Seyed Fazel
   Braidy, Nady
   Orhan, Ilkay Erdogan
   Badiee, Arash
   Daglia, Maria
   Nabavi, Seyed Mohammad
TI Rhodiola rosea L. and Alzheimer's Disease: From Farm to Pharmacy
SO PHYTOTHERAPY RESEARCH
LA English
DT Review
DE Neurodegeneration; Neuroinflammation; Neurotoxicity; Oxidative stress;
   Rhodiola rosea
ID INDUCED OXIDATIVE STRESS; SKELETAL-MUSCLE CELLS; LIPID-PEROXIDATION;
   PROTEIN OXIDATION; ROOT EXTRACT; KINASE; F-2-ISOPROSTANES; SALIDROSIDE;
   ACTIVATION; MECHANISMS
AB Rhodiola rosea L. (roseroot) is a common member of the family Crassulaceae, known as one of the most important popular medicinal plants in the northern region of Europe. The roots of R. rosea possess a wide range of pharmacological activities such as antioxidant, antiinflammatory, anticancer, cardioprotective, and neuroprotective effects that are because of the presence of different phytochemicals such as phenols and flavonoids. In addition, the presence of salidroside, rosavins, and p-tyrosol are responsible for its beneficial effects for the treatment of on depression, fatigue, and cognitive dysfunction. A plethora of studies report that R. rosea has potent neuroprotective effects through the suppression of oxidative stress, neuroinflammation, and excitotoxicity in brain tissues and antagonism of oncogenic p21-activated kinase. However, to our knowledge, no review articles have been published addressing the neuroprotective effects of R. rosea. Therefore, the present article aims at critically reviewing the available literature on the beneficial effects of R. rosea on as a therapeutic strategy for the treatment of Alzheimer's disease and other neurodegenerative diseases where oxidative stress plays a major role in disease development and progression. We also discuss the cultivation, phytochemistry, clinical impacts, and adverse effects of R. rosea to provide a broader insight on the therapeutic potential for this plant. Copyright (c) 2016 John Wiley & Sons, Ltd.
C1 [Nabavi, Seyed Fazel; Nabavi, Seyed Mohammad] Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, POB 19395-5487, Tehran, Iran.
   [Braidy, Nady] Univ New S Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia.
   [Orhan, Ilkay Erdogan] Gazi Univ, Dept Pharmacognosy, Fac Pharm, Ankara, Turkey.
   [Badiee, Arash] Mazandaran Univ Med Sci, Deputy Food & Drug, Sari, Iran.
   [Daglia, Maria] Univ Pavia, Med Chem & Pharmaceut Technol Sect, Dept Drug Sci, I-27100 Pavia, Italy.
C3 Baqiyatallah University of Medical Sciences (BMSU); University of New
   South Wales Sydney; Gazi University; Mazandaran University of Medical
   Sciences; University of Pavia
RP Nabavi, SM (corresponding author), Baqiyatallah Univ Med Sci, Appl Biotechnol Res Ctr, POB 19395-5487, Tehran, Iran.; Braidy, N (corresponding author), Univ New S Wales, Sch Psychiat, Ctr Hlth Brain Ageing, Sydney, NSW, Australia.
EM n.braidy@unsw.edu.au; Nabavi208@gmail.com
RI ERDOGAN ORHAN, ILKAY/H-6092-2011; Nabavi, Seyed Mohammad/G-5335-2010;
   nabavi, seyed fazel/A-2223-2010; Daglia, Maria/AAC-9498-2019; Braidy,
   Nady/G-4928-2012
OI ERDOGAN ORHAN, ILKAY/0000-0002-7379-5436; Daglia,
   Maria/0000-0002-4870-7713; Braidy, Nady/0000-0002-0497-5572
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NR 86
TC 75
Z9 93
U1 0
U2 98
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD APR
PY 2016
VL 30
IS 4
BP 532
EP 539
DI 10.1002/ptr.5569
PG 8
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA DJ1VQ
UT WOS:000373993500002
PM 27059687
DA 2026-05-27
ER

PT J
AU Shikov, AN
   Kosman, VM
   Flissyuk, EV
   Smekhova, IE
   Elameen, A
   Pozharitskaya, ON
AF Shikov, Alexander N.
   Kosman, Vera M.
   Flissyuk, Elena V.
   Smekhova, Irina E.
   Elameen, Abdelhameed
   Pozharitskaya, Olga N.
TI Natural Deep Eutectic Solvents for the Extraction of Phenyletanes and
   Phenylpropanoids of Rhodiola rosea L.
SO MOLECULES
LA English
DT Article
DE Rhodiola rosea; extraction; HPLC; optimization; salidroside; tyrosol;
   rosavin; rosin; cinnamyl alcohol
ID ULTRASOUND-ASSISTED EXTRACTION; BIOLOGICALLY-ACTIVE COMPOUNDS;
   CHEMICAL-COMPOSITION; BIOACTIVE COMPOUNDS; IONIC LIQUIDS; RHIZOMES;
   PLANTS; ADAPTOGENS; ROOTS
AB The extraction of Rhodiola rosea rhizomes using natural deep eutectic solvent (NADES) consisting of lactic acid, glucose, fructose, and water was investigated. A two-level Plackett-Burman design with five variables, followed by the steepest ascent method, was undertaken to determine the optimal extraction conditions. Among the five parameters tested, particle size, extraction modulus, and water content were found to have the highest impact on the extrability of phenyletanes and phenylpropanoids. The concentration of active compounds was analyzed by HPLC. The predicted results showed that the extraction yield of the total phenyletanes and phenylpropanoids (25.62 mg/g) could be obtained under the following conditions: extraction time of 154 min, extraction temperature of 22 degrees C, extraction modulus of 40, molar water content of 5:1:11 (L-lactic acid:fructose:water, mol/mol), and a particle size of rhizomes of 0.5-1 mm. These predicted values were further verified by validation experiments in predicted conditions. The experimental yields of salidroside, tyrosol, rosavin, rosin, cinnamyl alcohol and total markers (sum of phenyletanes and phenylpropanoids in mg/g) were 11.90 +/- 0.02, 0.36 +/- 0.02, 12.23 +/- 0.21, 1.41 +/- 0.01, 0.20 +/- 0.01, and 26.10 +/- 0.27 mg/g, respectively, which corresponded well with the predicted values from the models.
C1 [Shikov, Alexander N.; Flissyuk, Elena V.; Smekhova, Irina E.] St Petersburg State Chem Pharmaceut Univ, Prof Popov 14, St Petersburg, Russia.
   [Kosman, Vera M.] St Petersburg Inst Pharm, Kuzmolovo P 245, St Petersburg 188663, Russia.
   [Elameen, Abdelhameed] Norwegian Inst Bioecon Res, Pb 115, NO-1431 As, Norway.
   [Pozharitskaya, Olga N.] Russian Acad Sci MMBI KSC RAS, Murmansk Marine Biol Inst, Kola Sci Ctr, Vladimirskaya 17, Murmansk 183010, Russia.
C3 Norwegian Institute of Bioeconomy Research; Russian Academy of Sciences;
   Kola Science Centre of the Russian Academy of Sciences; Murmansk Marine
   Biological Institute
RP Shikov, AN (corresponding author), St Petersburg State Chem Pharmaceut Univ, Prof Popov 14, St Petersburg, Russia.; Elameen, A (corresponding author), Norwegian Inst Bioecon Res, Pb 115, NO-1431 As, Norway.
EM spb.pharmacy@gmail.com; kosmanvm@mail.ru;
   elena.flisyuk@pharminnotech.com; irina.smekhova@pharminnotech.com;
   abdelhameed.elameen@nibio.no; olgapozhar@mail.ru
RI Shikov, Alexander/B-1804-2008; Kosman, Vera/ABG-6399-2021;
   Pozharitskaya, Olga/D-9671-2014
OI Shikov, Alexander/0000-0003-4351-0695; Kosman, Vera/0000-0001-9690-1935;
   Pozharitskaya, Olga/0000-0003-1061-0665; Elameen,
   Abdelhameed/0000-0002-4158-7923
FU Norwegian Institute of Bioeconomy Research
FX This research received no external funding. The APC was funded by
   Norwegian Institute of Bioeconomy Research.
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NR 62
TC 80
Z9 87
U1 1
U2 32
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD APR 2
PY 2020
VL 25
IS 8
AR 1826
DI 10.3390/molecules25081826
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA LP9DX
UT WOS:000534617300040
PM 32316279
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, GD
   Zhao, YW
   Li, YJ
   Wang, XJ
   Si, HH
   Huang, WZ
   Wang, ZZ
   Ma, SP
   Xiao, W
AF Liu, Guang-Da
   Zhao, Yi-Wu
   Li, Yan-Jing
   Wang, Xue-Jing
   Si, Hai-Hong
   Huang, Wen-Zhe
   Wang, Zhen-Zhong
   Ma, Shi-Ping
   Xiao, Wei
TI Qualitative and quantitative analysis of major constituents from Dazhu
   Hongjingtian capsule by UPLC/Q-TOF-MS/MS combined with UPLC/QQQ-MS/MS
SO BIOMEDICAL CHROMATOGRAPHY
LA English
DT Article
DE Dazhu Hongjingtian capsule; qualitative and quantitative analysis;
   quality control; UPLC; Q-TOF MS; MS; UPLC-QQQ-MS; MS
ID FLIGHT MASS-SPECTROMETRY; RHODIOLA-KIRILOWII; RAT PLASMA; LIQUID;
   SALIDROSIDE; GLYCOSIDES; ROSEA; IDENTIFICATION; RADIX; L.
AB In this work, a sensitive and efficient method was established and validated for qualitative and quantitative analysis of major bioactive constituents in Dazhu Hongjingtian capsule by liquid chromatography tandem mass spectrometry. A total of 32 compounds were tentatively identified using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. Furthermore, 12 constituents, namely gallic acid, 3,4-dihydroxybenzoic acid, salidroside, p-coumaric acid-4-O--d-glucopyranoside, bergeninum, 4-hydroxybenzoic acid, 4-hydroxyphenylacetic acid, syringate, 6-O-galloylsalidroside, rhodiosin, rhodionin and kaempferol-7-O--l-rhamnoside, were simultaneously quantified by the developed ultra-performance liquid chromatography coupled with a triple quadrupole mass spectrometry method in 9min. All of them were analyzed on an Agilent ZorBax SB-C-18 column (3.0x100mm, 1.8m) with linear gradient elution of methanol-0.1% formic acid water. The proposed method was applied to analyze three batches of samples with acceptable linearity (R, 0.9979-0.9997), precision (RSD, 1.3-4.7%), repeatability (RSD, 1.7-4.9%), stability (RSD, 2.2-4.9%) and recovery (RSD, 0.6-4.4%) of the 12 compounds. As a result, the analytical method possessing high throughput and sensitivity is suitable for the quality control of Dazhu Hongjingtian capsule.
C1 [Liu, Guang-Da; Zhao, Yi-Wu; Li, Yan-Jing; Wang, Xue-Jing; Si, Hai-Hong; Huang, Wen-Zhe; Wang, Zhen-Zhong; Xiao, Wei] Jiangsu Kan Pharmaceut Co Ltd, State Key Lab New Tech Chinese Med Pharmaceut Pro, Lianyungang 222001, Peoples R China.
   [Liu, Guang-Da; Ma, Shi-Ping] China Pharmaceut Univ, Dept Pharmacol Chinese Mat Med, Nanjing, Jiangsu, Peoples R China.
C3 China Pharmaceutical University
RP Xiao, W (corresponding author), Jiangsu Kan Pharmaceut Co Ltd, State Key Lab New Tech Chinese Med Pharmaceut Pro, Lianyungang 222001, Peoples R China.
EM xw_kanion@163.com
RI xiao, wei/KCK-6954-2024
FU National Science and Technology Major Project 'Creation of Major New
   Drugs' from China [2013ZX09402203]
FX National Science and Technology Major Project 'Creation of Major New
   Drugs' from China, Grant/Award Number: 2013ZX09402203
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NR 29
TC 26
Z9 27
U1 3
U2 71
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-3879
EI 1099-0801
J9 BIOMED CHROMATOGR
JI Biomed. Chromatogr.
PD JUN
PY 2017
VL 31
IS 6
AR e3887
DI 10.1002/bmc.3887
PG 10
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA ET9CX
UT WOS:000400604700003
PM 27862112
DA 2026-05-27
ER

PT J
AU Ma, YG
   Wang, JW
   Bai, YG
   Liu, M
   Xie, MJ
   Dai, ZJ
AF Ma, Yu-Guang
   Wang, Jun-Wei
   Bai, Yun-Gang
   Liu, Mei
   Xie, Man-Jiang
   Dai, Zhi-Jun
TI Salidroside contributes to reducing blood pressure and alleviating
   cerebrovascular contractile activity in diabetic Goto-Kakizaki Rats by
   inhibition of L-type calcium channel in smooth muscle cells
SO BMC PHARMACOLOGY & TOXICOLOGY
LA English
DT Article
DE Salidroside; Contractile activity; Vascular smooth muscle cells (VSMCs);
   L-type Ca2+ channel (Ca-L)
ID CA2+ SPARKLET ACTIVITY; SIMULATED MICROGRAVITY; PULMONARY-HYPERTENSION;
   ACUTE HYPERGLYCEMIA; ACTIVATION; PROLIFERATION; APOPTOSIS; RHODIOLA;
   CURRENTS; THERAPY
AB Background: Vascular disease is a common and often severe complication in diabetes mellitus. Hyperglycemia and hypertension are considered to be two of the leading risk factors for vascular complications in diabetic patients. However, few pharmacologic agents could provide a combinational therapy for controlling hyperglycemia and blood pressure in diabetic patients at the same time. Salidroside (SAL) is the major active ingredient derived from Rhodiola. Recently, it has been reported that SAL have an obvious hypoglycemic effect in diabetes and show a beneficial activity in diabetic vascular dysfunction. However, it remains unknown whether or not SAL treatment could directly reduce blood pressure in diabetes. Furthermore, it is not clear what is the molecular mechanism underlying the vascular protection of SAL treatment in diabetes.
   Methods: Male diabetic Goto-Kakizaki (GK) and non-diabetic control Wistar-Kyoto (WKY) rats were administrated with different dosages of SAL (50, 100 and 200 mg/kg/day) for 4 weeks. Contractile responsiveness of cerebral artery to KCl or 5-HT was investigated by Pressure Myograph System. The activity of Ca-L channel was investigated by recording whole-cell currents, assessing the expressions of Ca-L channel alpha(1C)-subunit and its downstream kinase, MLCK, at protein or mRNA levels.
   Results: We showed that administration of 100 mg/kg/day SAL for 4 weeks not only lowered blood glucose, but also reduced blood pressure and alleviated cerebrovascular contractile activity in diabetic GK rats, which suggested that SAL treatment may provide a combinational therapy for lowering blood glucose and reducing blood pressure in diabetes at the same time. Furthermore, SAL treatment markedly inhibited the function and expression of Ca-L channel in cerebral VSMCs isolated from diabetic GK rats or when exposed to hyperglycemia condition, which may be the underlying mechanism responsible for the vascular protection of SAL in diabetes.
   Conclusions: The present study provided evidences that SAL contributes to reducing blood pressure and alleviating cerebrovascular contractile activity in diabetic GK rats by inhibition of Ca-L channel in smooth muscle cells, which may provide a novel approach to treat vascular complications in diabetic patients.
C1 [Ma, Yu-Guang; Liu, Mei; Dai, Zhi-Jun] Xi An Jiao Tong Univ, Med Coll, Affiliated Hosp 2, Dept Oncol, Xian 710004, Shaanxi Provinc, Peoples R China.
   [Wang, Jun-Wei] Shaanxi Prov Peoples Hosp, Dept Cardiovasc Med, Xian 710068, Shaanxi, Peoples R China.
   [Bai, Yun-Gang; Xie, Man-Jiang] Fourth Mil Med Univ, Dept Aerosp Physiol, Minist Educ, Key Lab Aerosp Med, Xian 710032, Shaanxi Provinc, Peoples R China.
C3 Xi'an Jiaotong University; Xi'an Medical University; Air Force Medical
   University
RP Dai, ZJ (corresponding author), Xi An Jiao Tong Univ, Med Coll, Affiliated Hosp 2, Dept Oncol, Xian 710004, Shaanxi Provinc, Peoples R China.; Xie, MJ (corresponding author), Fourth Mil Med Univ, Dept Aerosp Physiol, Minist Educ, Key Lab Aerosp Med, Xian 710032, Shaanxi Provinc, Peoples R China.
EM manjiangxie@hotmail.com; dzj0911@126.com
RI Dai, Zhi-Jun/O-6826-2014
OI Dai, Zhi-Jun/0000-0001-5209-8626
FU National Natural Science Foundation of China [31270904, 81471032]
FX This work was supported by National Natural Science Foundation of China
   ( No. 31270904 and 81471032). The funders had no role in study design,
   data collection and analysis, decision to publish, or preparation of the
   manuscript.
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NR 42
TC 27
Z9 29
U1 1
U2 22
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2050-6511
J9 BMC PHARMACOL TOXICO
JI BMC Pharmacol. Toxicol.
PD APR 26
PY 2017
VL 18
AR 30
DI 10.1186/s40360-017-0135-8
PG 15
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA ET4IP
UT WOS:000400243300001
PM 28441970
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Perinskaya, YS
   Sakanyan, EI
AF Perinskaya, Yu. S.
   Sakanyan, E. I.
TI Current State and Prospects of Developing Drugs Based on Rhizomes and
   Roots of Rhodiola rosea L.
SO PHARMACEUTICAL CHEMISTRY JOURNAL
LA English
DT Article
DE Rhodiola rosea; rhizomes and roots; adaptogen; salidroside; rosavin;
   rosiridin; extract
AB Rhizomes and roots of Rhodiola rosea L. (Crassulaceae) are popular and in demand. The plant has long been used in folk and traditional medicine and in official practice. However, the variety of drugs derived from the rhizomes and roots of R. rosea is very restricted despite the rather diverse phytochemical composition. Optimization of the production technology for medicinal preparations based on substances from this plant and their analytical methods are currently critical issues.
C1 [Perinskaya, Yu. S.] Minist Publ Hlth Russian Federat, State Sci Ctr Drug Expertise & Control, Moscow 127051, Russia.
   [Sakanyan, E. I.] Minist Publ Hlth Russian Federat, Ctr Pharmacopoeia & Int Cooperat, State Sci Ctr Drug Expertise & Control, Moscow 127051, Russia.
RP Perinskaya, YS (corresponding author), Minist Publ Hlth Russian Federat, State Sci Ctr Drug Expertise & Control, Moscow 127051, Russia.
OI Саканян, Елена Ивановна/0000-0002-1693-2422
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NR 32
TC 4
Z9 6
U1 0
U2 37
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0091-150X
EI 1573-9031
J9 PHARM CHEM J+
JI Pharm. Chem. J.
PD NOV
PY 2014
VL 48
IS 8
BP 525
EP 528
DI 10.1007/s11094-014-1143-2
PG 4
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA AX4JQ
UT WOS:000346899500007
DA 2026-05-27
ER

PT J
AU Yao, YY
   Ren, ZC
   Yang, RH
   Mei, YL
   Dai, YY
   Cheng, Q
   Xu, C
   Xu, XG
   Wang, SY
   Kim, KM
   Noh, JH
   Zhu, J
   Zhao, NW
   Liu, YU
   Mao, GX
   Sima, J
AF Yao, Yuyuan
   Ren, Zhichu
   Yang, Ruihan
   Mei, Yilan
   Dai, Yuying
   Cheng, Qian
   Xu, Chong
   Xu, Xiaogang
   Wang, Sanying
   Kim, Kyoung Mi
   Noh, Ji Heon
   Zhu, Jian
   Zhao, Ningwei
   Liu, Yong U.
   Mao, Genxiang
   Sima, Jian
TI Salidroside reduces neuropathology in Alzheimer's disease models by
   targeting NRF2/SIRT3 pathway
SO CELL AND BIOSCIENCE
LA English
DT Article
DE Alzheimer's disease; Mitochondrial protection; SAL; SIRT3; NRF2
ID A-BETA; COGNITIVE IMPAIRMENT; AMYLOID PLAQUES; MECHANISMS; SIRTUINS;
   SIRT3
AB Background Neurite dystrophy is a pathologic hallmark of Alzheimer's disease (AD). However, drug discovery targeting neurite protection in AD remains largely unexplored. Methods A beta-induced neurite and mitochondrial damage assays were used to evaluate A beta toxicity and the neuroprotective efficacy of a natural compound salidroside (SAL). The 5xFAD transgenic mouse model of AD was used to study the neuroprotective function of SAL. To verify the direct target of SAL, we used surface plasmon resonance and cellular thermal shift assays to analyze the drug-protein interaction. Results SAL ameliorates A beta-mediated neurite damage in cell culture. We further reveal that SAL represses mitochondrial damage in neurites by promoting mitophagy and maintaining mitochondrial homeostasis, dependent on an NAD-dependent deacetylase SIRT3. In AD mice, SAL protects neurite morphology, mitigates A beta pathology, and improves cognitive function, which are all SIRT3-dependent. Notably, SAL directly binds to transcription factor NRF2, inhibits its degradation by blocking its interaction with KEAP1 ubiquitin ligase, and then advances NRF2-mediated SIRT3 transcription. Conclusions Overall, we demonstrate that SAL, a potential anti-aging drug candidate, attenuates AD pathology by targeting NRF2/SIRT3 pathway for mitochondrial and neurite protection. Drug discovery strategies focusing on SAL may thus provide promising therapeutics for AD.
C1 [Yao, Yuyuan; Ren, Zhichu; Yang, Ruihan; Mei, Yilan; Dai, Yuying; Cheng, Qian; Xu, Chong; Sima, Jian] China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Lab Aging Neurosci & Neuropharmacol, Nanjing 210009, Peoples R China.
   [Xu, Xiaogang; Wang, Sanying; Mao, Genxiang] Zhejiang Hosp, Dept Geriatr, Inst Zhejiang Prov, Zhejiang Prov Key Lab Geriatr & Geriatr, Hangzhou 310030, Peoples R China.
   [Kim, Kyoung Mi] Chungnam Natl Univ, Dept Biol Sci, Daejeon 34134, South Korea.
   [Noh, Ji Heon] Chungnam Natl Univ, Dept Biochem, Daejeon 34134, South Korea.
   [Zhu, Jian] Eastern Illinois Univ, Dept Psychol, Charleston, IL 61920 USA.
   [Zhao, Ningwei] China Expos Inst, 781 Cai Lun Rd, Shanghai 200120, Peoples R China.
   [Liu, Yong U.] South China Univ Technol, Guangzhou Peoples Hosp 1, Lab Neurosci Hlth & Dis, Guangzhou 510180, Peoples R China.
C3 China Pharmaceutical University; Chungnam National University; Chungnam
   National University; Eastern Illinois University; South China University
   of Technology
RP Sima, J (corresponding author), China Pharmaceut Univ, Sch Basic Med & Clin Pharm, Lab Aging Neurosci & Neuropharmacol, Nanjing 210009, Peoples R China.; Mao, GX (corresponding author), Zhejiang Hosp, Dept Geriatr, Inst Zhejiang Prov, Zhejiang Prov Key Lab Geriatr & Geriatr, Hangzhou 310030, Peoples R China.
EM maogenxiang@163.com; simajian@cpu.edu.cn
RI ; wang, sanying/HIZ-7552-2022; Liu, Yong U/JVP-2621-2024; Kim, Kyoung
   Mi/AAE-9847-2021
OI Sima, Jian/0000-0002-4127-1638; wang, sanying/0000-0002-8172-876X; Liu,
   Yong U/0000-0003-1278-7114; Xu, Xiaogang/0000-0003-4364-5856; 
FU National Natural Science Foundation of China [82173804, 81771520];
   High-Level Talents Start-up Funding of China Pharmaceutical University
   [3150120042]
FX This work was supported by the National Natural Science Foundation of
   China (No. 82173804, No. 81771520) and the High-Level Talents Start-up
   Funding of China Pharmaceutical University (No. 3150120042).
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NR 53
TC 46
Z9 56
U1 3
U2 46
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 2045-3701
J9 CELL BIOSCI
JI Cell Biosci.
PD NOV 4
PY 2022
VL 12
IS 1
AR 180
DI 10.1186/s13578-022-00918-z
PG 18
WC Biochemistry & Molecular Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology
GA 5Y1JK
UT WOS:000879045900002
PM 36333711
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Cao, XX
   Li, HH
   Wang, M
   Ren, XL
   Deng, YR
AF Cao, Xuexiao
   Li, Huanhuan
   Wang, Meng
   Ren, Xiaoliang
   Deng, Yanru
TI Analysis of five active ingredients of Er-Zhi-Wan, a traditional Chinese
   medicine water-honeyed pill, using the biopharmaceutics classification
   system
SO BIOMEDICAL CHROMATOGRAPHY
LA English
DT Article
DE bioavailability; biopharmaceutics classification system; Er-Zhi-Wan;
   permeability; solubility
ID PREDICTING DRUG DISPOSITION; FRUCTUS LIGUSTRI LUCIDI;
   INTESTINAL-ABSORPTION; IN-VITRO; MENOPAUSAL SYNDROME; AQUEOUS
   SOLUBILITY; EXTRACT
AB Er-Zhi-Wan (EZW) is a traditional Chinese medicine with many clinical applications and used as a health product in East Asia. Five active ingredients (salidroside, specnuezhenide, nuezhenoside, luteolin, and oleanolic acid) were screened out from EZW to develop an in vitro rapid evaluation method for the classification of in vivo drug absorption behavior by biopharmaceutics classification system (BCS). Ultra-performance liquid chromatography was used for quantitative analysis. Solubility and permeability were assayed by equilibrium solubility and multiple models: everted rat intestinal sac model, cultured Caco-2 cells, octanol-water partition coefficient (LogP) method. The BCS properties of drugs were predicted using software applications, and the correlations of measured and predicted values of factors affecting oral drug absorption were calculated. The results were verified by measuring the absolute bioavailability of the active ingredients. Salidroside, specnuezhenide, and nuezhenoside were classified as BCS class III drugs, and luteolin was classified as a BCS class III/I drug because of the difference in LogP and intestinal permeability. Oleanolic acid was classified as a BCS class II/IV drug in acidic media and BCS class I/III drug in other media. Overall, EZW may be classified as a BCS class III drug, and permeability was identified as the primary factor limiting absorption. The results provide a novel method for the evaluation of the in vivo absorption of oral traditional Chinese medicines.
C1 [Cao, Xuexiao; Li, Huanhuan; Ren, Xiaoliang; Deng, Yanru] Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 300193, Peoples R China.
   [Wang, Meng] Tianjin Univ Tradit Chinese Med, Tianjin State Key Lab Modern Chinese Med, Tianjin, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine
RP Wang, M; Ren, XL (corresponding author), Tianjin Univ Tradit Chinese Med, Sch Chinese Mat Med, Tianjin 300193, Peoples R China.
EM wangmeng@tjutcm.edu.cn; renxiaoliang@tjutcm.edu.cn
FU National Natural Science Foundation of China [81873191, No. 81774149,
   No. 81873191, 81774149] Funding Source: Medline
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NR 29
TC 9
Z9 10
U1 0
U2 52
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0269-3879
EI 1099-0801
J9 BIOMED CHROMATOGR
JI Biomed. Chromatogr.
PD FEB
PY 2020
VL 34
IS 2
AR e4757
DI 10.1002/bmc.4757
PG 11
WC Biochemical Research Methods; Biochemistry & Molecular Biology;
   Chemistry, Analytical; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy
GA KF9CA
UT WOS:000509533200019
PM 31755125
DA 2026-05-27
ER

PT J
AU Huang, YL
   Huo, XL
   Liu, HJ
   Li, DN
   Yin, ZN
AF Huang, Yilin
   Huo, Xingli
   Liu, Huijun
   Li, Danni
   Yin, Zongning
TI Bile acids and polyphenols inhibit succinic anhydride-induced protein
   succinylation and amyloid aggregation: Mechanistic insights
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE Succinylation; Protein aggregation; Small molecules; Bile acids;
   Polyphenols
ID LIGAND-BINDING; THIOFLAVIN-T; CHOLIC-ACID; PATHOGENESIS
AB Lysine succinylation is a major post-translational modification affecting diverse proteins, and its excessive occurrence can lead to protein misfolding and aggregation-hallmarks of various proteinopathies, such as amyloid-beta and Tau tangle formation in Alzheimer's disease and islet amyloid polypeptide aggregation in type 2 diabetes. Here, we investigated the inhibitory effects of bile acid metabolites (deoxycholic acid, glycocholic acid, and taurocholic acid sodium) and natural polyphenols (anthocyanin and salidroside) on succinylation and succinylation-induced amyloid aggregation. Succinylation levels were evaluated using the ninhydrin assay before and after treatment, and aggregation behavior and structural alterations were characterized by SDS-PAGE, inverted fluorescence microscopy, and intrinsic fluorescence spectroscopy. Additionally, fluorescence quenching and molecular docking were used to explore the underlying mechanisms. All five small molecules significantly reduced succinylation in a concentration-dependent manner (p < 0.05). Among bile acids, taurocholic acid sodium exhibited the strongest suppression of aggregation (40.99 %), followed by glycocholic acid (28.32 %) and deoxycholic acid (27.94 %). Anthocyanin showed greater inhibition (33.81 %) than salidroside (26.54 %) (all p < 0.05). The results suggest that these small molecules inhibit succinylation-induced aggregation potentially by interacting with proteins and altering their conformations, thereby preventing excessive succinylation at lysine residues. This study provides new insight into the interplay between bile acid metabolism and protein homeostasis and highlights the therapeutic potential of natural compounds in preventing protein aggregation-related diseases.
C1 [Huang, Yilin; Huo, Xingli; Liu, Huijun; Li, Danni; Yin, Zongning] Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Sichuan Engn Lab Plant Sourced Drug, Educ Minist & Sichuan Prov, Chengdu 610041, Peoples R China.
   [Huang, Yilin; Huo, Xingli; Liu, Huijun; Li, Danni; Yin, Zongning] Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China.
C3 Sichuan University; Sichuan University
RP Yin, ZN (corresponding author), Sichuan Univ, Key Lab Drug Targeting & Drug Delivery Syst, Sichuan Engn Lab Plant Sourced Drug, Educ Minist & Sichuan Prov, Chengdu 610041, Peoples R China.; Yin, ZN (corresponding author), Sichuan Univ, Sichuan Res Ctr Drug Precis Ind Technol, West China Sch Pharm, Chengdu 610041, Peoples R China.
EM zongningyin@163.com
FU Natural Science Foundation of Sichuan Province [2024NSFSC0572]
FX This research was financially supported by the Natural Science
   Foundation of Sichuan Province (No. 2024NSFSC0572) .
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NR 48
TC 1
Z9 1
U1 0
U2 1
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD NOV
PY 2025
VL 773
AR 110601
DI 10.1016/j.abb.2025.110601
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA FO1XA
UT WOS:001723419200001
PM 40854493
DA 2026-05-27
ER

PT J
AU Yu, S
   Xu, H
   Chi, XJ
   Wei, L
   Cheng, Q
   Yang, YM
   Zhou, C
   Ding, F
AF Yu, Shu
   Xu, Hui
   Chi, Xiaojing
   Wei, Li
   Cheng, Qiong
   Yang, Yumin
   Zhou, Chun
   Ding, Fei
TI 2-(4-Methoxyphenyl)ethyl-2-Acetamido-2-deoxy-β-D-pyranoside (A
   Salidroside Analog) Confers Neuroprotection with a Wide Therapeutic
   Window by Regulating Local Glucose Metabolism in a Rat Model of Cerebral
   Ischemic Injury
SO NEUROSCIENCE
LA English
DT Article
DE 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxy-beta-D-pyranoside;
   therapeutic time window; glucose metabolism; positron emission
   tomography (PET); glucose transporter; ischemic stroke
ID INDUSTRY-ROUND-TABLE; ANIMAL-MODELS; IN-VIVO; STROKE; BRAIN; CELL;
   TRANSPORTERS; CONTRIBUTES; ACTIVATION; INDUCTION
AB 2-(4-Methoxyphenyl)ethyl-2-acetamido-2-deoxy-beta-D-pyranoside (salidroside analog-4g, SalA-4g), has shown neuroprotective prospects for the treatment of ischemic stroke. However, the dose-response and time window study for SalA-4g, and the mechanism of SalA-4g-mediated neuroprotection remain unclear. Here, we systematically investigated the therapeutic time window and dosage of SalA-4g in permanent focal cerebral ischemia in rats. SalA-4g dose-dependently improved stroke outcome. Either pre-treatment or post-treatment of SalA-4g exhibited notable neuroprotection, and maintained for up to 6 h after ischemia onset. Moreover, significant neurological functional recovery was found after SalA-4g administration in long-term functional assays. Further studies suggested that SalA-4g ameliorated neuronal cell death, elevated local glucose metabolism and enhanced the expression level of glucose transporter 1 and 3 in the ipsilateral cortex and striatum. We suggest that data of this study are critical in exploring the clinical application prospects of SalA-4g for the treatment of ischemic stroke. (C) 2018 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Yu, Shu; Xu, Hui; Chi, Xiaojing; Wei, Li; Cheng, Qiong; Yang, Yumin; Ding, Fei] Nantong Univ, Key Lab Neuroregenerat Jiangsu, 19 Qixiu Rd, Nantong 226001, JS, Peoples R China.
   [Yu, Shu; Xu, Hui; Chi, Xiaojing; Wei, Li; Cheng, Qiong; Yang, Yumin; Ding, Fei] Nantong Univ, Minist Educ, Coinnovat Ctr Neuroregenerat, 19 Qixiu Rd, Nantong 226001, JS, Peoples R China.
   [Zhou, Chun; Ding, Fei] Nantong Univ, Affiliated Hosp, Dept Neurol, Jiangsu Clin Med Ctr Tissue Engn & Nerve Injury R, 20 Xisi Rd, Nantong 226001, JS, Peoples R China.
C3 Nantong University; Nantong University; Nantong University
RP Ding, F (corresponding author), Nantong Univ, Key Lab Neuroregenerat Jiangsu, 19 Qixiu Rd, Nantong 226001, JS, Peoples R China.; Ding, F (corresponding author), Nantong Univ, Minist Educ, Coinnovat Ctr Neuroregenerat, 19 Qixiu Rd, Nantong 226001, JS, Peoples R China.; Zhou, C; Ding, F (corresponding author), Nantong Univ, Affiliated Hosp, Dept Neurol, Jiangsu Clin Med Ctr Tissue Engn & Nerve Injury R, 20 Xisi Rd, Nantong 226001, JS, Peoples R China.
EM wyc2578@sina.com; dingfei@ntu.edu.cn
RI ; DING, FEI/KLD-8925-2024
OI Yu, Shu/0000-0003-3771-267X; 
FU National Key Basic Research Program of China (973 program)
   [2014CB542203]; National Natural Science Foundation of China [81401094,
   81501058]; Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD); Jiangsu Provincial Key Medical Center
FX This work was supported by the National Key Basic Research Program of
   China (973 program, Grant No. 2014CB542203), National Natural Science
   Foundation of China (Grant Nos. 81401094, 81501058), a Project Funded by
   the Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD), and Jiangsu Provincial Key Medical Center. We thank
   the researchers at the Department of Nuclear Medicine, Fudan University
   Shanghai Cancer Center for their help in performing 18F-FDG PET/MRI.
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NR 36
TC 14
Z9 14
U1 0
U2 14
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD NOV 1
PY 2018
VL 391
BP 60
EP 72
DI 10.1016/j.neuroscience.2018.09.006
PG 13
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA GW7UG
UT WOS:000447176700005
PM 30223020
DA 2026-05-27
ER

PT J
AU Kapoor, S
   Raghuvanshi, R
   Bhardwaj, P
   Sood, H
   Saxena, S
   Chaurasia, OP
AF Kapoor, Sahil
   Raghuvanshi, Rinky
   Bhardwaj, Pushpender
   Sood, Hemant
   Saxena, Shweta
   Chaurasia, Om Prakash
TI Influence of light quality on growth, secondary metabolites production
   and antioxidant activity in callus culture of Rhodiola imbricata
   Edgew
SO JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
LA English
DT Article
DE Callus culture; Light quality; Rhodiola imbricata; Secondary
   metabolites; Salidroside; Antioxidant activity
ID CELL-SUSPENSION-CULTURES; EMITTING-DIODES; BLUE-LIGHT; BIOCHEMICAL
   VARIATIONS; PHENOLIC-COMPOUNDS; GENE-EXPRESSION; SALIDROSIDE; PLANTS;
   ROOT; BIOSYNTHESIS
AB Rhodiola imbricata is a rare medicinal herb well-known for its adaptogenic and antioxidant properties due to the presence of a diverse array of secondary metabolites, including phenylethanoids and phenylpropanoids. These secondary metabolites are generating considerable interest due to their potential applications in pharmaceutical and nutraceutical industries. The present study investigated the influence of light quality on growth, production of industrially important secondary metabolites and antioxidant activity in callus cultures of Rhodiola imbricata. Callus cultures of Rhodiola imbricata were established under different light conditions: 100% red, 100% blue, 100% green, RGB (40% red: 40% green: 20% blue) and 100% white (control). The results showed that the callus cultures grown under red light accumulated maximum amount of biomass (7.43 g/l) on day 21 of culture, as compared to other light conditions. Maximum specific growth rate (0.126 days(-1)) and doubling time (132.66 h) was observed in callus cultures grown under red light. Reverse phase-high performance liquid chromatographic (RP-HPLC) analysis revealed that the callus cultures exposed to blue light accumulated maximum amount of Salidroside (3.12 mg/g DW) on day 21 of culture, as compared to other light conditions. UV-Vis spectrophotometric analysis showed that the callus cultures exposed to blue light accumulated maximum amount of total phenolics (11.84 mg CHA/g DW) and total flavonoids (5.53 mg RE/g DW), as compared to other light conditions. Additionally, callus cultures grown under blue light displayed enhanced DPPH free radical scavenging activity (53.50%). Callus cultures grown under different light conditions showed no significant difference in ascorbic acid content (11.05-13.90 mg/g DW) and total antioxidant capacity (27.37-30.17 mg QE/g DW). The correlation analysis showed a positive correlation between total phenolic content and DPPH free radical scavenging activity in callus cultures (r = 0.85). Taken together, these results demonstrate the remarkable potential of light quality on biomass accumulation and production of industrially important secondary metabolites in callus cultures of Rhodiola imbricata. This study will open new avenues and perspectives towards abiotic elicitation strategies for sustainable growth and enhanced production of bioactive compounds in in-vitro cultures of Rhodiola imbricata.
C1 [Kapoor, Sahil; Raghuvanshi, Rinky; Bhardwaj, Pushpender; Saxena, Shweta; Chaurasia, Om Prakash] Def Inst High Altitude Res DRDO, 56 APO, Leh Ladakh 901205, Jammu & Kashmir, India.
   [Sood, Hemant] Jaypee Univ Informat Technol, Dept Biotechnol & Bioinformat, Waknaghat Solan 173215, Himachal Prades, India.
C3 Defence Research & Development Organisation (DRDO); Defence Institute of
   High Altitude Research (DIHAR); Jaypee University of Information
   Technology
RP Chaurasia, OP (corresponding author), Def Inst High Altitude Res DRDO, 56 APO, Leh Ladakh 901205, Jammu & Kashmir, India.
EM opchaurasiadihardrdo@gmail.com
RI /AAL-3516-2021; Chaurasia, Om Prakash/AAP-3358-2021
OI , shweta/0000-0001-8171-4264; Chaurasia, Om Prakash/0000-0003-2921-2755;
   Kapoor, Sahil/0000-0002-1483-6760
FU Defence Research & Development Organization (DRDO), Ministry of Defence,
   Government of India
FX The authors wish to acknowledge Defence Research & Development
   Organization (DRDO), Ministry of Defence, Government of India, for
   financial support. Authors also wish to acknowledge Dr. Somen Acharya
   for providing necessary facility.
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NR 74
TC 109
Z9 118
U1 1
U2 64
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 1011-1344
EI 1873-2682
J9 J PHOTOCH PHOTOBIO B
JI J. Photochem. Photobiol. B-Biol.
PD JUN
PY 2018
VL 183
BP 258
EP 265
DI 10.1016/j.jphotobiol.2018.04.018
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA GJ1SV
UT WOS:000435049000030
PM 29747145
DA 2026-05-27
ER

PT J
AU Li, L
   Gao, B
   Zhang, WX
   Yang, J
   Zhang, J
   Luo, F
AF Li, Li
   Gao, Bo
   Zhang, Wen-xue
   Yang, Jun
   Zhang, Jin
   Luo, Fang
TI Development of the Rhodiola rosea Fuqu and Rhodiola rosea
   soy sauce, and the determination of their functional properties
SO JOURNAL OF THE INSTITUTE OF BREWING
LA English
DT Article
DE Rhodiola rosea Fuqu; soy sauce; antioxidant activity; HPLC-ESI-MS/MS
ID SACHALINENSIS; SALIDROSIDE; EXTRACT; CHROMATOGRAPHY; FERMENTATION; ROOTS
AB A mixed starter, composed of high-quality Rhodiola rosea Fuqu, was developed. Compared with normal Fuqu, Rhodiola rosea Fuqu demonstrated higher spore numbers, spore germination rates, protease activity, liquefying amylase activity and total acid and amino acid nitrogen. Specifically, the spore number was 1.36 times that of regular Fuqu. Protease activity, liquefying amylase activity, total acid and amino acid nitrogen were 0.475 g/100mL, 104.16 U/g dry Qu, 35.67 mmol/L and 26.08 g/100mL, respectively. These values were 21.48, 7.41, 6.07 and 67.82% higher than the regular Fuqu. The Rhodiola rosea soy sauce indices were also better than those for the control. The DPPH scavenging abilities of R. rosea soy sauce, control soy sauce, market soy sauce 1 and market soy sauce 2 were 74.25, 44.01, 34.73 and 11.38%, respectively. The total phenolic content in these four samples was 387.38, 309.23, 212.85 and 202.60mg GAE/g, respectively. As observed with the DPPH and total phenolic assay, the R. rosea soy sauce showed the highest antioxidant capacity. A simple, rapid, and sensitive determination method of salidroside in R. rosea Fuqu and R. rosea soy sauce using HPLC-ESI-MS/MS was developed and validated with multiple reaction monitoring in the negative mode.
C1 [Li, Li; Zhang, Wen-xue; Yang, Jun; Zhang, Jin; Luo, Fang] Sichuan Univ, Coll Light Ind & Food Engn, Chengdu 610065, Peoples R China.
   [Li, Li] Sichuan Univ Sci & Engn, Coll Biotechnol Engn, Zigong 643000, Peoples R China.
   [Gao, Bo] Sichuan Univ, Analyt & Testing Ctr, Chengdu 610065, Peoples R China.
   [Zhang, Wen-xue] Sichuan Univ, Jinjiang Coll, Coll Liquor Sci, Meishan 620860, Peoples R China.
C3 Sichuan University; Sichuan University of Science & Engineering; Sichuan
   University; Sichuan University
RP Li, L (corresponding author), Sichuan Univ Sci & Engn, Coll Biotechnol Engn, Zigong 643000, Peoples R China.; Gao, B (corresponding author), Sichuan Univ, Analyt & Testing Ctr, Chengdu 610065, Peoples R China.
EM li_li821008@163.com; bogao@scu.edu.cn
FU International Science and Technology Cooperation Projects of People's
   Republic of China [2011DFA30560]; Luzhou LaoJiao Research Scholarship
   [15ljzk07]; Sichuan University Science and Engineering [2015RC11]; Youth
   Foundation of Sichuan University [2014SCU11045]
FX This work was financially supported by International Science and
   Technology Cooperation Projects of People's Republic of China (Grant
   2011DFA30560), Luzhou LaoJiao Research Scholarship (15ljzk07),
   scientific research fund of Sichuan University Science and Engineering
   (2015RC11), Youth Foundation of Sichuan University (2014SCU11045).
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NR 27
TC 5
Z9 5
U1 2
U2 46
PU INST BREWING
PI LONDON
PA 33 CLARGES STREET, LONDON W1Y 8EE, ENGLAND
SN 0046-9750
EI 2050-0416
J9 J I BREWING
JI J. Inst. Brew.
PD JUN
PY 2016
VL 122
IS 2
BP 355
EP 362
DI 10.1002/jib.323
PG 8
WC Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Food Science & Technology
GA DP2XS
UT WOS:000378357400022
OA gold
DA 2026-05-27
ER

PT J
AU Wang, XB
   Tang, Y
   Xie, N
   Bai, JR
   Jiang, SN
   Zhang, Y
   Hou, Y
   Meng, XL
AF Wang, Xiaobo
   Tang, Yan
   Xie, Na
   Bai, Jinrong
   Jiang, Shengnan
   Zhang, Yi
   Hou, Ya
   Meng, Xianli
TI Salidroside, a phenyl ethanol glycoside from Rhodiola crenulata,
   orchestrates hypoxic mitochondrial dynamics homeostasis by stimulating
   Sirt1/p53/Drp1 signaling
SO JOURNAL OF ETHNOPHARMACOLOGY
LA English
DT Article
DE Salidroside; Hypoxia; HT22 cells; Mitochondrial dynamics homeostasis;
   Sirt1/p53/Drp1 signaling
ID INJURY; PROLIFERATION; MITOPHAGY; FISSION; P53
AB Ethnopharmacological relevance: Rhodiola crenulata is clinically used to combat hypobaric hypoxia brain injury at high altitude with the function of invigorating Qi and promoting blood circulation in Tibetan medicine. Salidroside (Sal), an active compound identified from Rhodiola species, has been shown to exert neuroprotective effects against hypoxic brain injury. However, its mitochondrial protective mechanisms remain largely unknown. Aim of the study: The present study aimed to explore the mitochondrial protection of Sal and the involved mechanisms related to mitochondrial dynamics homeostasis on hypoxia-induced injury of HT22 cells. Materials and methods: Hypoxic condition was performed as cells cultured in a tri-gas incubator with 1% O-2, 5% CO2 and 94% N-2. We firstly investigated the effects of different concentrations of Sal on the viability of normal or hypoxic HT22 cells. Whereafter, the levels of lactate dehydrogenase (LDH), superoxide dismutase (SOD), malondialdehyde (MDA), adenosine triphosphate (ATP) and Na+-K+-ATPase were tested by commercial kits. Meanwhile, mitochondrial superoxide, intracellular reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) were determined by specific labeled probes. Mitochondrial morphology was detected by mitotracker green with confocal microscopy. Additionally, the potential interactions of Sal with Sirt1/p53/Drp1 signaling pathway-related proteins were predicted and tested by molecular docking and localized surface plasmon resonance (LSPR) techniques, respectively. Furthermore, the protein levels of Sirt1, p53, ac-p53, Drp1, pDrp1(s616), Fis1 and Mfn2 were estimated by western blot analysis. Results: Sal alleviated hypoxia-induced oxidative stress in HT22 cells as evidenced by increased cell viability and SOD activity, while decreased LDH release and MDA content. The protected mitochondrial function by Sal treatment was indicated by the increases of ATP level, Na+-K+-ATPase activity and MMP. Miraculously, Sal reduced hypoxia-induced mitochondrial fission, while increased mitochondrial tubular or linear morphology. The results of molecular docking and LSPR confirmed the potential binding of Sal to proteins Sirt1, p53, Fis1 and Mfn2 with affinity values 1.38 x 10(-2), 5.26 x 10(-3), 6.46 x 10(-3) and 7.26 x 10(-3+) KD, respectively. And western blot analysis further demonstrated that Sal memorably raised the levels of Sirt1 and Mfn2, while decreased the levels of ac-p53, Drp1, p-Drp1 (s616) and Fis1. Conclusion: Collectively, our data confirm that Sal can maintain mitochondrial dynamics homeostasis by activating the Sirt1/p53/Drp1 signaling pathway.
C1 [Wang, Xiaobo; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Res Inst Integrated TCM & Western Med, Chengdu, Peoples R China.
   [Wang, Xiaobo; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu, Peoples R China.
   [Tang, Yan; Xie, Na; Bai, Jinrong; Jiang, Shengnan; Hou, Ya; Meng, Xianli] Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
   [Zhang, Yi] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine; Chengdu University of Traditional
   Chinese Medicine; Chengdu University of Traditional Chinese Medicine
RP Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Res Inst Integrated TCM & Western Med, Chengdu, Peoples R China.; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Innovat Inst Chinese Med & Pharm, Chengdu, Peoples R China.; Hou, Y; Meng, XL (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China.
EM 283116384@qq.com; xlm999@edutcm.edu.cn
FU National Natural Science Foundation of China [82104533, 81973569]; China
   Postdoctoral Science Foundation [2020M683273]; Science & Technology
   Department of Sichuan Province [2021YJ0175]; National Key R&D Program of
   China [2017YFC1703904]; Regional Innovation and Cooperation Project of
   the Science & Technology Department of Sichuan Province [2020YFQ0032];
   Key R&D and Transformation Program of the Science & Technology
   Department of Qinghai Province [2020-SF-C33]
FX This work was supported by the National Natural Science Foundation of
   China (82104533 and 81973569), the China Postdoctoral Science Foundation
   (2020M683273), the Science & Technology Department of Sichuan Province
   (2021YJ0175), the National Key R&D Program of China (2017YFC1703904),
   the Regional Innovation and Cooperation Project of the Science &
   Technology Department of Sichuan Province (2020YFQ0032), and the Key R&D
   and Transformation Program of the Science & Technology Department of
   Qinghai Province (2020-SF-C33).
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PU ELSEVIER IRELAND LTD
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SN 0378-8741
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VL 293
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EA APR 2022
PG 12
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA 1F2MJ
UT WOS:000795006600004
PM 35439546
DA 2026-05-27
ER

PT J
AU Yu, SX
   Liu, WQ
AF Yu, Shengxue
   Liu, Wenqiang
TI Protective effects of Salidroside against ferroptosis through
   PPARG-dependent mechanism in diabetes-related cognitive impairment
SO EXPERIMENTAL NEUROLOGY
LA English
DT Article
DE Diabetes-related cognitive impairment; Ferroptosis; Salidroside;
   PPARG/Nrf2 pathway; protective effects
AB Objective: This study focused on investigating the benefits and potential mechanism of Sal in Leptin gene knockout mice (db/db) and primary hippocampal neurons. Methods: In the current investigation, male db/db mice were administered Sal via oral gavage. Cognitive functions and learning and memory capacities were assessed through the Morris Water Maze (MWM) tests, respectively. Nissl, Fluoro-Jade C (FJC) staining techniques were employed to gauge hippocampal neuronal damage. Transmission electron microscopy facilitated the observation of mitochondrial alterations within hippocampal neurons of db/db mice. We further quantified Fe2+ levels, oxidative stress, and lipid peroxidation both in vivo & vitro. Western blotting got utilized to ascertain the relative levels of GPX4, PPARG, Nrf2 protein expressions. Results: According to the study results, Sal supplement could dramatically relieve db/db mice' cognitive impairment and protect neurons, through the inhibition of oxidative stress and the reduction of neuronal ferroptosis. According to further research, Sal could achieve a direct binding with peroxisome proliferator-activated receptor gamma (PPARG) for promoting it to be expressed. When culturing hippocampus-derived primary neurons, adding PPARG antagonist GW9662 or Nrf2 antagonist ML385 could eliminate the effect of Sal. Conclusion: Taken together, the study is the first one that demonstrates the effectiveness of Sal in improving the cognitive impairment deficits of db/db mice as well as its inhibitory effect on oxidative stress and neuronal ferroptosis via PPARG-dependent mechanism.
C1 [Yu, Shengxue; Liu, Wenqiang] Jinzhou Med Univ, Liaoning Key Lab Diabet Cognit & Percept Dysfunct, Jinzhou 121001, Peoples R China.
   [Liu, Wenqiang] Jinzhou Med Univ, Sch Basic Med, Dept Anat, Jinzhou 121001, Peoples R China.
C3 Jinzhou Medical University; Jinzhou Medical University
RP Liu, WQ (corresponding author), Jinzhou Med Univ, Dept Anat, 40 Songpo Rd,Kangning St, Jinzhou 121001, Peoples R China.
EM liuwenqiang@jzmu.edu.cn
FU Basic Research Project for Higher Education Institutions of Liaoning
   Provincial Department of Education (Youth Project) [LJ212410160055];
   Basic Scientific Research Projects of Liaoning Provincial Department of
   Education [LJKMZ20222081]; Jinzhou Science and Technology Guidance
   Program [JZ2023B083]
FX This project completed with the support of the Basic Research Project
   for Higher Education Institutions of Liaoning Provincial Department of
   Education (Youth Project) (LJ212410160055) ; Basic Scientific Research
   Projects of Liaoning Provincial Department of Education (LJKMZ20222081)
   ; Jinzhou Science and Technology Guidance Program (JZ2023B083) .
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NR 33
TC 9
Z9 9
U1 4
U2 7
PU ACADEMIC PRESS INC ELSEVIER SCIENCE
PI SAN DIEGO
PA 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
SN 0014-4886
EI 1090-2430
J9 EXP NEUROL
JI Exp. Neurol.
PD AUG
PY 2025
VL 390
AR 115261
DI 10.1016/j.expneurol.2025.115261
EA APR 2025
PG 12
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA 2HZ8W
UT WOS:001483121200001
PM 40262718
DA 2026-05-27
ER

PT J
AU Huang, GQ
   Cai, YW
   Ren, MH
   Zhang, XY
   Fu, Y
   Cheng, R
   Wang, YD
   Miao, MX
   Zhu, LP
   Yan, TH
AF Huang, Guiqin
   Cai, Yawen
   Ren, Menghui
   Zhang, Xiaoyu
   Fu, Yu
   Cheng, Run
   Wang, Yingdi
   Miao, Mingxing
   Zhu, Lingpeng
   Yan, Tianhua
TI Salidroside sensitizes Triple-negative breast cancer to ferroptosis by
   SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy
SO JOURNAL OF ADVANCED RESEARCH
LA English
DT Article
DE Salidroside; Triple-negative breast cancer; Ferroptosis; mTOR;
   SCD1-mediated lipogenesis; NCOA4-mediated ferritinophagy
ID CELL-DEATH; GROWTH; MTOR; DEGRADATION; METABOLISM; AUTOPHAGY; STRESS;
   NCOA4
AB Introduction: Triple-negative breast cancer (TNBC) is the primary cause of breast cancer-induced death in women. Literature has confirmed the benefits of Salidroside (Sal) in treating TNBC. However, the study about potential therapeutic targets and mechanisms of Sal-anchored TNBC remains limited. Objective: This study was designed to explore the main targets and potential mechanisms of Sal against TNBC. Methods: Network pharmacology, bioinformatics, and machine learning algorithm strategies were integrated to examine the role, potential targets, and mechanisms of the Sal act in TNBC. MDA-MB-231 cells and tumor-bearing nude mice were chosen for in vitro and in vivo experimentation. Cell viability and cytotoxicity were determined using CCK-8, LDH test, and Calcein-AM/PI staining. Antioxidant defense, lipid peroxidation, and iron metabolism were explored using glutathione, glutathione peroxidase, malondialdehyde (MDA), C11-BODIPY 581/591 probe, and FerroOrange dye. Glutathione peroxidase 4 (GPX4) or stearoyl-CoA desaturase 1 (SCD1) overexpression or nuclear receptor co-activator 4 (NCOA4) deficiency was performed to demonstrate the mechanism of Sal on TNBC. Results: The prediction results confirmed that 22 ferroptosis-related genes were identified in Sal and TNBC, revealing that the potential mechanism of the Sal act on TNBC was linked with ferroptosis. Besides, these genes were mainly involved in the mTOR, PI3K/AKT, and autophagy signaling pathway by functional enrichment analysis. The in vitro validation results confirmed that Sal inhibited TNBC cell proliferation by modulating ferroptosis via elevation of intracellular Fe2+ and lipid peroxidation. Mechanistically, Sal sensitized TNBC cells to ferroptosis by inhibiting the PI3K/AKT/mTOR axis, thereby suppressing SCD1-mediated lipogenesis of monounsaturated fatty acids to induce lipid peroxidation, additionally facilitating NCOA4-mediated ferritinophagy to increase intracellular Fe2+ content. The GPX4 or SCD1 overexpression or NCOA4 deficiency results further supported our mechanistic studies. In vivo experimentation confirmed that Sal is vital for slowing down tumor growth by inducing ferroptosis. Conclusions: Overall, this study elucidates TNBC pathogenesis closely linked to ferroptosis and identifies potential biomarkers in TNBC. Meanwhile, the study elucidates that Sal sensitizes TNBC to ferroptosis by SCD1-mediated lipogenesis and NCOA4-mediated ferritinophagy, regulated by PI3K/AKT/mTOR signaling pathways. Our findings provide a theoretical basis for applying Sal to treat TNBC. (c) 2024 The Authors. Published by Elsevier B.V. on behalf of Cairo University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
C1 [Huang, Guiqin; Cai, Yawen; Ren, Menghui; Zhang, Xiaoyu; Fu, Yu; Cheng, Run; Wang, Yingdi; Yan, Tianhua] China Pharmaceut Univ, Sch Basic Med Sci & Clin Pharm, Nanjing 210009, Jiangsu, Peoples R China.
   [Zhu, Lingpeng] Nanjing Med Univ, Affiliated Wuxi Peoples Hosp, Wuxi Peoples Hosp, Wuxi Med Ctr, Wuxi 214023, Jiangsu, Peoples R China.
   [Miao, Mingxing] China Pharmaceut Univ, Natl Expt Teaching Demonstrat Ctr Pharm, Nanjing 211198, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; Jiangnan University; Nanjing Medical
   University; China Pharmaceutical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, Sch Basic Med Sci & Clin Pharm, Nanjing 210009, Jiangsu, Peoples R China.; Zhu, LP (corresponding author), Nanjing Med Univ, Affiliated Wuxi Peoples Hosp, Wuxi Peoples Hosp, Wuxi Med Ctr, Wuxi 214023, Jiangsu, Peoples R China.; Miao, MX (corresponding author), China Pharmaceut Univ, Natl Expt Teaching Demonstrat Ctr Pharm, Nanjing 211198, Jiangsu, Peoples R China.
EM mmx0224@cpu.edu.cn; zhulingpeng@njmu.edu.cn; 1020050806@cpu.edu.cn
RI ; Cai, Yawen/OKR-6198-2025; Su, Tianyuan/Y-7054-2019
OI Yan, Tianhua/0000-0001-6124-8630; 
FU National Natural Science Foun-dation of China [82201220]; Natural
   Science Foundation of Jiangsu Province [BK20190149]; Postdoctoral
   Science Founda-tion of China [2020 M681669]; Youth Project of Wuxi
   Munici-pal Health Commission [Q202042]; General Program of Wuxi Medical
   Center [WMCG202324]; Fundamental Research Funds for the Central
   Universities [2632023GR19]
FX The work was supported by the National Natural Science Foun-dation of
   China (No. 82201220) ; Natural Science Foundation of Jiangsu Province
   (No. BK20190149) ; Postdoctoral Science Founda-tion of China (No. 2020
   M681669) ; Youth Project of Wuxi Munici-pal Health Commission (No.
   Q202042) ; General Program of Wuxi Medical Center (No. WMCG202324) ;
   Fundamental Research Funds for the Central Universities (No.
   2632023GR19) .
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NR 75
TC 64
Z9 65
U1 51
U2 102
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 2090-1232
EI 2090-1224
J9 J ADV RES
JI J. Adv. Res.
PD AUG
PY 2025
VL 74
BP 589
EP 607
DI 10.1016/j.jare.2024.09.027
EA JUL 2025
PG 19
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 6DN1F
UT WOS:001550771200009
PM 39353532
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Hao, YJ
   Zhang, KX
   Jin, MY
   Piao, XC
   Lian, ML
   Jiang, J
AF Hao, Yue-Jun
   Zhang, Ke-Xin
   Jin, Mei -Yu
   Piao, Xuan-Chun
   Lian, Mei-Lan
   Jiang, Jun
TI Improving fed-batch culture efficiency of Rhodiola
   sachalinensis cells and optimizing flash extraction process of
   polysaccharides from the cultured cells by BBD-RSM
SO INDUSTRIAL CROPS AND PRODUCTS
LA English
DT Article
DE Rhodiola sachalinensis; Fed -batch culture; Initial culture medium; Salt
   concentration; Polysaccharides; Flash extraction
ID ULTRASONIC-ASSISTED EXTRACTION; RESPONSE-SURFACE METHODOLOGY;
   ANTIMICROBIAL ACTIVITIES; AMINO-ACIDS; ANTIOXIDANT; OPTIMIZATION;
   ANTIBACTERIAL; BIOSYNTHESIS; SALIDROSIDE; CALCIUM
AB Fed-batch culture of plant cells can enhance biomass and bioactive compound accumulation compared with batch culture, in which the initial culture medium is one of the controllable factors in the fed-batch culture system. Rhodiola sachalinensis is a valuable medicinal herb and its cell culture is an alternative approach to obtaining plant material. R. sachalinensis cells has been previously cultured in a fed-batch culture system and the initial culture medium has been found to critically affect production yield. Therefore, this study investigated the effect of nitrogen concentration, ammonia and nitrate ratio (NH4+/NO3-), and phosphorus and calcium concen-trations in initial culture medium on cell biomass, as well as salidroside and polysaccharide accumulation to improve the fed-batch culture efficiency. Then, the cultured cells were extracted by flash extraction and the extraction conditions were optimized by Box-Behnken Design Response Surface Method (BBD-RSM). Finally, the antibacterial and antibiofilm effects of the extract were examined to further utilize R. sachalinensis cell cultures. The results showed that the fed-batch culture efficiency was obviously improved when the initial culture medium was modified as 30 mM of nitrogen with 5/25 of NH4+/NO3-, 0.94 mM of phosphorus, and 2.3 mM of calcium, at which 277.3 mg/L of salidroside and 4.5 g/L of polysaccharides were obtained In flash extraction, poly-saccharide yield was as the response value to optimize extraction process by controlling extraction time, extraction temperature, and liquid-solid ratio in the BBD-RSM experiments. The optimal flash extraction con-ditions were 55.7 s of extraction time, 56.5 degrees C of extraction temperature, and 37.0 mL/g of liquid-solid ratio, which the polysaccharide yield reached 12.76% under the optimized conditions. In antibacterial experiment, the cell extract (RCE) inhibited the growth of Bacillus subtilis, Pseudomonas aeruginosa, and Salmonella choleraesuis; the biofilm of B. subtilis and S. choleraesuis was scavenged in the groups of 8 mg/mL and 16 mg/mL RCE. The findings provided a basis for further industrial production of cell cultures and a theoretical reference in using R. sachalinensis cells in the production of antibacterial-related products.
C1 [Hao, Yue-Jun; Zhang, Ke-Xin; Jin, Mei -Yu; Piao, Xuan-Chun; Lian, Mei-Lan] Yanbian Univ, Key Lab Nat Med Changbai Mt, Minist Educ, Pk Rd 977, Yanji 133002, Jilin, Peoples R China.
   [Jiang, Jun] Yanbian Univ, Key Innovat Lab Deep & Intens Proc Yanbian High Qu, Minist Agr & Rural Affairs, Pk Rd 977, Yanji 133002, Jilin, Peoples R China.
C3 Yanbian University; Yanbian University
RP Lian, ML (corresponding author), Yanbian Univ, Key Lab Nat Med Changbai Mt, Minist Educ, Pk Rd 977, Yanji 133002, Jilin, Peoples R China.; Jiang, J (corresponding author), Yanbian Univ, Key Innovat Lab Deep & Intens Proc Yanbian High Qu, Minist Agr & Rural Affairs, Pk Rd 977, Yanji 133002, Jilin, Peoples R China.
EM lianmeilan2001@163.com; jiangjun@ybu.edu.cn
RI ; Lian, Mei-Lan/R-7420-2017
OI Jiang, Jun/0000-0001-5345-9016; Lian, Mei-Lan/0000-0002-3420-9908
FU National Natural Science Foundation of China [81960685]; Science and
   Technology Department of Jilin Province [20210101231JC]
FX This work was supported by National Natural Science Foundation of China
   (81960685) and Science and Technology Department of Jilin Province
   (20210101231JC) .
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NR 59
TC 29
Z9 32
U1 4
U2 48
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0926-6690
EI 1872-633X
J9 IND CROP PROD
JI Ind. Crop. Prod.
PD JUN
PY 2023
VL 196
AR 116513
DI 10.1016/j.indcrop.2023.116513
EA MAR 2023
PG 10
WC Agricultural Engineering; Agronomy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA 9Y3UD
UT WOS:000950384300001
DA 2026-05-27
ER

PT J
AU Du, QY
   He, QX
   Zhang, FM
   Mi, J
   Li, YY
   Wang, SH
   Zhang, Y
AF Du, Qinyun
   He, Qingxiu
   Zhang, Fengming
   Mi, Jiao
   Li, Yuying
   Wang, Shaohui
   Zhang, Yi
TI An In Vitro Dissolution Determination of Multi-Index Components
   in Tibetan Medicine Rhodiola Granules
SO JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
LA English
DT Article
AB The composition of the Tibetan medicine Rhodiola granules (RG) is complex, and the overall quality of RG is difficult to determine. Therefore, establishing a method to determine the multi-component in vitro dissolution of RG is of great significance for quality control. This study uses the second paddle method of the fourth general rule 0931 from the Chinese Pharmacopoeia (2020 edition), compliant with apparatus 2 of the United States Pharmacopeia (USP). The dissolution apparatus was set to a rotation speed of 100 rpm with ultrapure water as the dissolution medium. A sample volume of 1 mL was collected at each timepoint. Furthermore, the cumulative dissolution of gallic acid, salidroside, and ethyl gallic acid in RG at different time points was determined by high-performance liquid chromatography (HPLC). Finally, the dissolution curves were drawn, and the curves were fitted to the GompertzMod, the Gompertz, the Logistic, and the Weibull equations. The results showed that the cumulative dissolution of gallic acid in RG was over 80% at 1 min, the cumulative dissolution of salidroside and ethyl gallic acid was over 65% at 5 min, and the cumulative dissolution of each index component decreased after 30 min. The curve fitting demonstrated that the GompertzMod equation was the best-fitting model for each index component of RG. In conclusion, the dissolution test method described in this protocol is simple, accurate, and reliable. It can characterize the dissolution behavior of the index components in RG in vitro, which provides a methodological reference for quality control of RG and quality evaluation of other ethnic compounds.
C1 [Du, Qinyun; Wang, Shaohui; Zhang, Yi] Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu, Peoples R China.
   [He, Qingxiu] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu, Peoples R China.
   [Zhang, Fengming; Mi, Jiao; Li, Yuying] Tibet Rhodiola Pharmaceut Holding Co Ltd, Shanghai, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine; Chengdu University
   of Traditional Chinese Medicine
RP Wang, SH; Zhang, Y (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Pharm, Chengdu, Peoples R China.
EM winter9091@163.com; zhangyi@cdutcm.edu.cn
RI Wang, Shaohui/HKO-6774-2023
OI Wang, Shaohui/0000-0002-4203-4941
FU National Key Research and Development Program of China [2017YFC1703904];
   University (Chengdu University of TCM) - enterprise (Tibet Rhodiola
   Pharmaceutical Holding Co. LTD) [1052022040101]; Regional Innovation and
   Cooperation Project of the Science & Technology Department of Sichuan
   Province [2020YFQ0032]; Key R&D and Transformation Program of the
   Science & Technology Department of Qinghai Province [2020-SF-C33]
FX This work was funded by the National Key Research and Development
   Program of China (2017YFC1703904), the University (Chengdu University of
   TCM) - enterprise (Tibet Rhodiola Pharmaceutical Holding Co. LTD)
   cooperation project (1052022040101); the Regional Innovation and
   Cooperation Project of the Science & Technology Department of Sichuan
   Province (2020YFQ0032); and the Key R&D and Transformation Program of
   the Science & Technology Department of Qinghai Province (2020-SF-C33).
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Z9 1
U1 5
U2 25
PU JOURNAL OF VISUALIZED EXPERIMENTS
PI CAMBRIDGE
PA 1 ALEWIFE CENTER, STE 200, CAMBRIDGE, MA 02140 USA
SN 1940-087X
J9 JOVE-J VIS EXP
JI J. Vis. Exp.
PD NOV
PY 2022
IS 189
AR e64670
DI 10.3791/64670
PG 13
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 7U0YC
UT WOS:000911862800040
PM 36408988
DA 2026-05-27
ER

PT J
AU Nikolaichuk, H
   Choma, IM
   Morlock, GE
AF Nikolaichuk, Hanna
   Choma, Irena M.
   Morlock, Gertrud E.
TI Effect-Directed Profiling of Akebia quinata and Clitoria
   ternatea via High-Performance Thin-Layer Chromatography, Planar
   Assays and High-Resolution Mass Spectrometry
SO MOLECULES
LA English
DT Article
DE HPTLC-EDA; HPTLC-heart cut-HPLC-HESI-HRMS; bioassay; enzyme inhibition
   assay; inhibitor; genotoxicity; genotoxin; antioxidant; radical
   scavenger; antibacterial; antimicrobial; estrogen; androgen; agonist;
   antagonist; endocrine activity
ID GLYCOSIDES; EXTRACT; TRITERPENOIDS; ANTHOCYANINS; PERICARPS; L.
AB Two herbal plants, Akebia quinata D. leaf/fruit and Clitoria ternatea L. flower, well-known in traditional medicine systems, were investigated using a non-target effect-directed profiling. High-performance thin-layer chromatography (HPTLC) was combined with 11 different effect-directed assays, including two multiplex bioassays, for assessing their bioactivity. Individual active zones were heart-cut eluted for separation via an orthogonal high-performance liquid chromatography column to heated electrospray ionization high-resolution mass spectrometry (HPLC-HESI-HRMS) for tentative assignment of molecular formulas according to literature data. The obtained effect-directed profiles provided information on 2,2-diphenyl-1-picrylhydrazyl scavenging, antibacterial (against Bacillus subtilis and Aliivibrio fischeri), enzyme inhibition (tyrosinase, alpha-amylase, beta-glucuronidase, butyrylcholinesterase, and acetylcholinesterase), endocrine (agonists and antagonists), and genotoxic (SOS-Umu-C) activities. The main bioactive compound zones in A. quinata leaf were tentatively assigned to be syringin, vanilloloside, salidroside, alpha-hederin, cuneataside E, botulin, and oleanolic acid, while salidroside and quinatic acids were tentatively identified in the fruit. Taraxerol, kaempherol-3-rutinoside, kaempferol-3-glucoside, quercetin-3-rutinoside, and octadecenoic acid were tentatively found in the C. ternatea flower. This straightforward hyphenated technique made it possible to correlate the biological properties of the herbs with possible compounds. The meaningful bioactivity profiles contribute to a better understanding of the effects and to more efficient food control and food safety.
C1 [Nikolaichuk, Hanna; Morlock, Gertrud E.] Justus Liebig Univ Giessen, Inst Nutr Sci, Chair Food Sci, Heinrich Buff Ring 26-32, D-35392 Giessen, Germany.
   [Nikolaichuk, Hanna; Choma, Irena M.] Marie Curie Sklodowska Univ, Fac Chem, Dept Chromatog, Maria Curie Sklodowska Sq 3, PL-20031 Lublin, Poland.
   [Nikolaichuk, Hanna] Med Univ Lublin, Fac Biomed, Dept Bioanalyt, Jaczewskiego St 8b, PL-20090 Lublin, Poland.
C3 Justus Liebig University Giessen; Maria Curie-Sklodowska University;
   Medical University of Lublin
RP Morlock, GE (corresponding author), Justus Liebig Univ Giessen, Inst Nutr Sci, Chair Food Sci, Heinrich Buff Ring 26-32, D-35392 Giessen, Germany.
EM gertrud.morlock@ernaehrung.uni-giessen.de
RI ; Choma, Irena/AAG-9790-2021; Morlock, Gertrud/E-6343-2013
OI Nikolaichuk, Hanna/0000-0001-6292-483X; Choma,
   Irena/0000-0002-6878-3748; Morlock, Gertrud/0000-0001-9406-0351
FU Maria Curie-Sklodowska University, Lublin, Poland; Deutsche
   Forschungsgemeinschaft [INST 162/471-1 FUGG, INST 162/536-1 FUGG]
FX The 6-month research stay of H.N. at JLU Giessen was funded by the
   project International Doctorate Study in Chemistry at Maria
   Curie-Sklodowska University, Lublin, Poland. Instrumentation was
   partially funded by the Deutsche Forschungsgemeinschaft (INST 162/471-1
   FUGG; INST 162/536-1 FUGG).
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NR 68
TC 8
Z9 8
U1 2
U2 29
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD APR
PY 2023
VL 28
IS 7
AR 2893
DI 10.3390/molecules28072893
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA D6XP0
UT WOS:000970141000001
PM 37049655
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, T
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   Liu, Jiajun
   Li, Qian
   Wang, Jing
   Liang, Yuan
   Bian, Liujiao
   Zhao, Xinfeng
TI Screening bioactive compounds with multi-targets from Rhodiola
   crenulata by a single column containing co-immobilized
   beta2-adrenergic receptor and voltage dependent anion channel
   isoform 1
SO JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL
   AND LIFE SCIENCES
LA English
DT Article
DE Multiple targets; Bioactive compounds; Immobilized receptor; Rhodiola
   crenulata
ID PERFORMANCE AFFINITY-CHROMATOGRAPHY; ZONAL ELUTION; PROTEIN;
   SPECTROMETRY; ANTAGONISTS; INHIBITORS; STRATEGY; BINDING; GROWTH
AB The pursuit of drugs having improved therapeutic efficacy necessitates increasing research on new assays for screening bioactive compounds with multi-targets. This work synthesized a chromatographic stationary phase containing co-immobilized beta(2)-adrenergic receptor (beta(2)-AR) and voltage dependent anion channel isoform 1 (VDAC-1) to achieve such purpose. Specific ligands of the two receptors (e.g. salbutamol, methoxyphenamine, ATP and NADH) were utilized to characterize the specificity and bioactivity of the column. Validated application of the stationary phase was performed by screening multi-target compounds of Rhodiola crenulata using high performance affinity chromatography coupled with ESI-Q-TOF-MS. By zonal elution, we identified salidroside as a bioactive compound simultaneously binding to beta(2)-AR and VDAC-1. The compound exhibited the binding sites of 1.0 x 10(-7) and 4.0 x 10(-7) M on the beta(2)-AR and VDAC-1. On these sites, the association constants were calculated to be 3.3 x 10(4) and 1.0 x 10(4) M-1. Molecular docking indicated that the binding of salidroside to the two receptors occurred on Ser(169) and Phe(255)of beta(2)-AR, and the channel wall of VDAC-1. Taking together, we concluded that the column containing co-immobilized receptors has potential for screening bioactive compounds with multi-targets from complex matrices including traditional Chinese medicines.
C1 [Liu, Ting; Liu, Jiajun; Li, Qian; Wang, Jing; Liang, Yuan; Bian, Liujiao; Zhao, Xinfeng] Northwest Univ, Coll Life Sci, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, Xian 710069, Shaanxi, Peoples R China.
   [Hou, Yani] Xian Peihua Univ, Sch Med, Xian 710025, Shaanxi, Peoples R China.
C3 Northwest University Xi'an; Xi'an Peihua University
RP Zhao, XF (corresponding author), Northwest Univ, Coll Life Sci, Minist Educ, Key Lab Resource Biol & Biotechnol Western China, Xian 710069, Shaanxi, Peoples R China.
EM zhaoxf@nwu.edu.cn
RI Liu, Ting/JTV-4688-2023
OI Li, Qian/0000-0002-1837-0208
FU National Natural Science Foundation of China [21775119, 21705126,
   81702832]; Postdoctoral Science Foundation of China [2017M620467];
   Program for Changjiang Scholars and Innovative Research Team in
   University [IRT_15R55]; Key Research and Development Program of Shaanxi
   Province [2017ZDCXL-SF-01-02-01]
FX We are grateful for the financial support by the grant from the National
   Natural Science Foundation of China (Nos. 21775119, 21705126 and
   81702832), the Postdoctoral Science Foundation of China (No.
   2017M620467), the Program for Changjiang Scholars and Innovative
   Research Team in University (No. IRT_15R55), and the Key Research and
   Development Program of Shaanxi Province (2017ZDCXL-SF-01-02-01).
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NR 39
TC 10
Z9 12
U1 1
U2 34
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1570-0232
EI 1873-376X
J9 J CHROMATOGR B
JI J. Chromatogr. B
PD NOV 15
PY 2018
VL 1100
BP 76
EP 82
DI 10.1016/j.jchromb.2018.09.029
PG 7
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA HA0JC
UT WOS:000449893300011
PM 30292952
DA 2026-05-27
ER

PT J
AU Zhang, YY
   Fan, XL
   Ge, HF
   Yu, YL
   Li, JZ
   Zhou, ZL
AF Zhang, Yanyan
   Fan, Xiaoli
   Ge, Hongfan
   Yu, Yaling
   Li, Jianzeng
   Zhou, Zhenlei
TI The effect of salidroside on the bone and cartilage properties in
   broilers
SO POULTRY SCIENCE
LA English
DT Article
DE Rhodiola rosea extract; chicken; bone strength; bone metabolism; femoral
   head
ID OSTEOBLAST DIFFERENTIATION; GROWTH; STRENGTH; BMP2; ENVIRONMENT;
   PREVALENCE
AB Leg disorders frequently occur in fast-growing broiler chickens, constituting severe health and welfare problems. Although salidroside (SAL) promotes osteogenesis and inhibits apoptosis of chondrocytes in rats, it remains to be determined whether SAL can effectively improve bone growth in broilers. The present study was designed to investigate the effects of dietary SAL supplementation on bone and cartilage characteristics in broiler chickens. Ninety-six Arbor Acres broiler chickens were randomly divided into 4 groups: control, low-dose SAL, medium-dose SAL, and high-dose SAL groups. The broiler chickens were raised until 42 d of age, with samples of bone and cartilage collected for biomechanical testing and bone metabolism index detection. The results showed that SAL significantly increased the vertical external diameter, cross-sectional moment of inertia, and cross-sectional area of the femur and tibia. Additionally, SAL enhanced bone mineral density and strength, as evidenced by significant increases in stiffness, Young's modulus, ultimate load, and fracture work of the femur and tibia. Furthermore, SAL influenced the relative content of phosphate, carbonate, and amide I in cortical bone. Moreover, SAL upregulated the expression of osteogenic genes (Collagen-1, RUNX2, BMP2, and ALP) in a dose-dependent manner and maintained the homeostasis of the extracellular matrix (ECM) of chondrocytes. These results indicated that SAL promoted leg health in broilers by improving bone and cartilage quality and enhancing chondrocyte activity.
C1 [Zhang, Yanyan; Fan, Xiaoli; Ge, Hongfan; Yu, Yaling; Li, Jianzeng; Zhou, Zhenlei] Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China.
C3 Nanjing Agricultural University
RP Zhou, ZL (corresponding author), Nanjing Agr Univ, Coll Vet Med, Nanjing 210095, Peoples R China.
EM zhouzl@njau.edu.cn
RI Zhou, Zhenlei/AFS-6215-2022; fan, xiaoli/NJS-4489-2025; Ge,
   Hongfan/OFN-2437-2025
FU National Natural Sci-ence Foundation of China [32273080]; Jiangsu
   Province Graduate Practice Innovation Pro-gram Project [SJCX24_0241]
FX This work was supported by the National Natural Sci-ence Foundation of
   China (No. 32273080) and the Jiangsu Province Graduate Practice
   Innovation Pro-gram Project (SJCX24_0241) . The authors would like to
   thank all the reviewers who participated in the review.
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NR 49
TC 1
Z9 1
U1 1
U2 9
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0032-5791
EI 1525-3171
J9 POULTRY SCI
JI Poult. Sci.
PD DEC
PY 2024
VL 103
IS 12
AR 104274
DI 10.1016/j.psj.2024.104274
EA SEP 2024
PG 13
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA G4H2A
UT WOS:001316261000001
PM 39270480
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wu, LT
   Xu, H
   Cao, L
   Li, T
   Li, RR
   Feng, Y
   Chen, JZ
   Ma, J
AF Wu, Leitao
   Xu, Hang
   Cao, Liang
   Li, Tao
   Li, Ruru
   Feng, Yang
   Chen, Jianzong
   Ma, Jing
TI Salidroside Protects against MPP plus -Induced Neuronal Injury through
   DJ-1-Nrf2 Antioxidant Pathway
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID PARKINSONS-DISEASE; NITRIC-OXIDE; INDUCED NEUROTOXICITY; INDUCED
   APOPTOSIS; CELLS; DJ-1; MPTP; NRF2; INVOLVEMENT; PREVENTS
AB Parkinson's disease (PD) is the second most common neurodegenerative disorder. We have found that salidroside ( Sal) exhibited neuroprotective effects against MPP+ toxicity. However, the molecular mechanism is not fully understood. In this study, we found that Sal significantly prevented MPP+-induced decrease of mRNA and protein expression of Nrf2, GCLc, SOD1, and SOD2 in SH-SY5Y cells. Moreover, silencing of Nrf2 significantly inhibited Sal-induced increase in mRNA and protein expression of GCLc, SOD1, and SOD2. But Nrf2 silence did not significantly impact Sal-exhibited effects on DJ-1 expression. Silencing of Nrf2 significantly suppressed the decrease of apoptosis induced by Sal in MPP+-treated SH-SY5Y cells. Sal significantly prevented MPP+-induced decrease of the mRNA and protein expression of DJ-1 in SH-SY5Y cells. Moreover, silencing of DJ-1 significantly inhibited Sal-induced increase in mRNA and protein expression of Nrf2, GCLc, SOD1, and SOD2 in MPP+-treated SH-SY5Y cells. These results indicated that DJ-1 was an upstream regulator of Nrf2 in the neuroprotective effects of Sal. Furthermore, silencing of DJ-1 significantly suppressed the decrease of apoptosis induced by Sal in MPP+-treated SH-SY5Y cells. In conclusion, Sal prevented MPP+-induced neurotoxicity through upregulation of DJ-1-Nrf2- antioxidant pathway. Our findings provide novel insights into the neuroprotective effects of Sal against PD.
C1 [Wu, Leitao; Li, Tao; Li, Ruru; Feng, Yang; Chen, Jianzong] Fourth Mil Med Univ, Xijing Hosp, Res Ctr Tradit Chinese Med, Xian 710032, Shaanxi, Peoples R China.
   [Xu, Hang] Fourth Mil Med Univ, Xijing Hosp, Dept Pharm, 169 West Changle Rd, Xian 710032, Shaanxi, Peoples R China.
   [Cao, Liang; Ma, Jing] Fourth Mil Med Univ, Xijing Hosp, Dept Chinese Med, 169 West Changle Rd, Xian 710032, Shaanxi, Peoples R China.
C3 Air Force Medical University; Air Force Medical University; Air Force
   Medical University
RP Chen, JZ (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Res Ctr Tradit Chinese Med, Xian 710032, Shaanxi, Peoples R China.; Ma, J (corresponding author), Fourth Mil Med Univ, Xijing Hosp, Dept Chinese Med, 169 West Changle Rd, Xian 710032, Shaanxi, Peoples R China.
EM jzchen57@fmmu.edu.cn; jingma@fmmu.edu.cn
RI Li, Tao/LJM-1988-2024; Ma, Jing/L-1330-2017
FU Natural Science Foundation of China [81173590]
FX This work was supported by grants from the Natural Science Foundation of
   China (Project no. 81173590).
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NR 44
TC 19
Z9 22
U1 1
U2 18
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
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PY 2017
VL 2017
AR 5398542
DI 10.1155/2017/5398542
PG 11
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA FI7AI
UT WOS:000412147600001
PM 29234413
OA Green Submitted, hybrid
DA 2026-05-27
ER

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   Liu, Le-Qiang
   Wang, Hong-Ju
   Tang, Bi
   Gao, Qin
   Kang, Pin-Fang
TI Salidroside ameliorates hypoxic pulmonary hypertension by regulating the
   two-pore domain potassium TASK-1 channel
SO PHYTOMEDICINE
LA English
DT Article
DE Hypoxic pulmonary hypertension; Sal; Pulmonary ring; PASMCs; TASK-1
ID MUSCLE; PROLIFERATION
AB Background: Hypoxic pulmonary vasoconstriction (HPV) is a reflex constriction of vascular smooth muscle. This study aims to investigate the role of Salidroside (Sal) in pulmonary arterial dilatation and the potential mechanism of Sal regulating hypoxic pulmonary hypertension in vitro and in vivo. Methods: A rat model of hypoxic pulmonary hypertension (HPH) was constructed using hypoxic chamber. The effect of Sal on HPH were evaluated using vascular ring, whole cell patch-clamp, WGA staining, HE staining, and Sirius Scarlet staining assays. Results: Sal treatment alleviated the injury of acute hypoxia on pulmonary circulation in SD rats. Meanwhile, Sal treatment reduced the pulmonary vascular tone of acute hypoxia in a concentration-dependent manner, which was involved in the TWIK-related acid-sensitive potassium channel 1 (TASK-1) mediating diastolic effect. We found that Sal treatment significantly increased the TASK-1 current of pulmonary artery smooth muscle cells (PASMCs) in a concentration-dependent manner, as well as reversed the inhibitory effect of acute hypoxia on the TASK-1 current. Moreover, Sal treatment improved the TASK-1 current density, suppressed the proliferation, and enhanced the apoptosis of PASMCs in SD rats under continuous hypoxic condition. In addition, we found that the electrophysiological remodeling and pulmonary vascular remodeling of PASMCs were improved by the treatment of Sal through the regulation of TASK-1 channel. Conclusions: Sal could alleviate HPH by restoring the function of TASK-1 channel, which may provide a novel method for the treatment of HPH.
C1 [Sun, Zheng-Yu; Lu, Guo-Qing; Sun, Hong-Yan; Wang, Lei; Wang, Hong-Ju; Tang, Bi; Kang, Pin-Fang] Bengbu Med Coll, Affiliated Hosp 1, Dept Cardiovasc Med, Bengbu 233000, Anhui, Peoples R China.
   [Jiang, Wen-Di] Bengbu Med Univ, Sch Lab Med, Dept Biochem & Mol Biol, Bengbu 233000, Anhui, Peoples R China.
   [Wang, Yu-Hang] Bengbu Med Univ, Sch Clin Med, Bengbu 233000, Anhui, Peoples R China.
   [Jiang, Wen-Di] Bengbu Med Univ, Key Lab Canc Res & Clin Lab Diag, Bengbu 233000, Peoples R China.
   [Sun, Zheng-Yu; Lu, Guo-Qing; Sun, Hong-Yan; Wang, Lei; Gao, Qin; Kang, Pin-Fang] Bengbu Med Univ, Key Lab Basic & Clin Cardiovasc & Cerebrovasc Dis, Bengbu 233004, Anhui, Peoples R China.
   [Gao, Qin] Bengbu Med Univ, Dept Physiol, Bengbu 233000, Anhui, Peoples R China.
   [Liu, Le-Qiang] Bengbu Med Univ, Sch Gen Practice Med, 2600 Dong Hai Ave, Bengbu 233000, Anhui, Peoples R China.
C3 Bengbu Medical University; Bengbu Medical University; Bengbu Medical
   University; Bengbu Medical University; Bengbu Medical University; Bengbu
   Medical University; Bengbu Medical University
RP Tang, B; Kang, PF (corresponding author), Bengbu Med Coll, Affiliated Hosp 1, Dept Cardiovasc Med, Bengbu 233000, Anhui, Peoples R China.; Kang, PF (corresponding author), Bengbu Med Univ, Affiliated Hosp 1, Dept Cardiovasc Dis, 287 Chang Huai Ave, Bengbu 233004, Peoples R China.
EM bitang2000@163.com; kangpinfang.1016@163.com
OI Wang, Yu-Hang/0009-0001-8801-8672
FU National Natural Science Foundation of China [81970313]; Collaborative
   Innovation Project of Anhui University [GXXT-2020-019]; Anhui Province
   Natural Science Foundation [2208085MH192]; Anhui Province Outstanding
   Youth Project [2022AH030141]; Anhui Province Excellent Scientific
   Research and Innovation Team [2022AH010083]; Research Innovation Team of
   Bengbu Medical College [BYKC201906]; Natural Science Research Project of
   Anhui Educational Committee [202304295107020034]; National Undergraduate
   Innovation and Entrepreneurship Project
FX The current study was generously supported by a range of esteemed
   funding sources, including the National Natural Science Foundation of
   China (Grant No. 81970313) , the Collaborative Innovation Project of
   Anhui University (Project No. GXXT-2020-019) , the Anhui Province
   Natural Science Foundation (Grant Nos. 2208085MH192) , the Anhui
   Province Outstanding Youth Project (Grant No. 2022AH030141) , the Anhui
   Province Excellent Scientific Research and Innovation Team (Grant No.
   2022AH010083) , the Research Innovation Team of Bengbu Medical College
   (BYKC201906) , the Natural Science Research Project of Anhui Educational
   Committee (Grant No. 202304295107020034) , and the National
   Undergraduate Innovation and Entrepreneurship Project
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NR 37
TC 9
Z9 10
U1 2
U2 8
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD DEC
PY 2024
VL 135
AR 156206
DI 10.1016/j.phymed.2024.156206
EA NOV 2024
PG 20
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA M1N1E
UT WOS:001355267400001
PM 39520952
DA 2026-05-27
ER

PT J
AU Li, XH
   Wang, XB
   Hong, DX
   Zeng, SY
   Su, JS
   Fan, G
   Zhang, Y
AF Li, Xuanhao
   Wang, Xiaobo
   Hong, Daoxin
   Zeng, Shangyu
   Su, Jinsong
   Fan, Gang
   Zhang, Yi
TI Metabolic Discrimination of Different Rhodiola Species Using
   1H-NMR and GEP Combinational Chemometrics
SO CHEMICAL & PHARMACEUTICAL BULLETIN
LA English
DT Article
DE Rhodiola; hydrogen NMR; gene expression programming; metabolomics;
   analysis
ID TRADITIONAL TIBETAN MEDICINE; PRODUCTS
AB Rhodiola is widely consumed in traditional folk medicine and nutraceuticals. To establish a procedure for the hydrogen (H-1)-NMR spectroscopic fingerprinting of secondary metabolites from three different Rhodiola species, the variation among three Rhodiola species were studied using H-1-NMR metabolomics combined with multivariate data analysis. Gene expression programming (GEP) was used to generate a formula to distinguish Rhodiola crenulata from two other Rhodiola species. Finally, HPLC was used to demonstrate the results. Same metabolites were compared by quantitative H-1-NMR (qNMR). Three Rhodiola species were clearly discriminated by H-1-NMR fingerprinting involved 22 nuclear magnetic signals of chemical constituents. y = d(166) x 2 + C-1 + d(56) + d(236) - d(128) x C-2 can be used to distinguish R. crenulata from two other Rhodiola species by GEP. The gallic acid concentration in R. crenulata was significantly higher than in the other. Rhodiola species as was the level of salidroside. R. crenulata also exhibited substantially higher levels of alpha-glucose. The fatty acid level in Rhodiola kirilowii was lower than the other species. These findings demonstrated that H-1-NMR fingerprinting combined with principal component analysis (PCA), partial least squares discriminant analysis (PLS-DA), hierarchical cluster analysis (HCA) and GEP can be used to distinguish different Rhodiola species and these methods were applicable and effective approaches for metabolic analysis, species differentiation, and quality assessment. In addition, gallic acid, salidroside, alpha-D-glucose, glycine, alanine, caffeic acid and tyrosol and are the discriminators.
C1 [Li, Xuanhao; Wang, Xiaobo; Hong, Daoxin; Zeng, Shangyu; Su, Jinsong; Fan, Gang; Zhang, Yi] Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu 611137, Sichuan, Peoples R China.
C3 Chengdu University of Traditional Chinese Medicine
RP Fan, G; Zhang, Y (corresponding author), Chengdu Univ Tradit Chinese Med, Sch Ethn Med, Chengdu 611137, Sichuan, Peoples R China.
EM fangang1111@163.com; 1175332408@qq.com
RI Su, Jinsong/JXM-6940-2024; Fan, Gang/AGG-2500-2022
FU National Natural Science Foundation [81203000]; National Key Research
   and Development Program of China [2017YFC1703900]
FX We would like to acknowledge funding from National Natural Science
   Foundation (No. 81203000) and the National Key Research and Development
   Program of China (No. 2017YFC1703900) for supporting this work.
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NR 38
TC 14
Z9 18
U1 2
U2 59
PU PHARMACEUTICAL SOC JAPAN
PI TOKYO
PA 2-12-15 SHIBUYA, SHIBUYA-KU, TOKYO, 150-0002, JAPAN
SN 0009-2363
J9 CHEM PHARM BULL
JI Chem. Pharm. Bull.
PD FEB
PY 2019
VL 67
IS 2
BP 81
EP 87
PG 7
WC Chemistry, Medicinal; Chemistry, Multidisciplinary; Pharmacology &
   Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Chemistry
GA HJ9HX
UT WOS:000457510600001
PM 30518724
OA gold
DA 2026-05-27
ER

PT J
AU Liu, K
   Li, MM
   Ren, XM
   You, QS
   Wang, F
   Wang, S
   Ma, CH
   Li, WN
   Ye, Q
AF Liu, Kun
   Li, Manman
   Ren, Xiumei
   You, Qing-sheng
   Wang, Fei
   Wang, Shuo
   Ma, Chun-Hui
   Li, Wei-Nan
   Ye, Qing
TI Huang Qi Tong Bi Decoction Attenuates Myocardial Ischemia-Reperfusion
   Injury via HMGB1/TLR/NF-B Pathway
SO MEDIATORS OF INFLAMMATION
LA English
DT Article
ID ACUTE LUNG INJURY; INHIBITION; SALIDROSIDE; RATS
AB The aim of this study was to study the protective effect of Huang Qi Tong Bi Decoction (HQTBT) on the heart of rats. Ischemia-reperfusion injury was established by coronary artery ligation. Proinflammatory cytokines were decreased by XFZY in coronary artery ligated rats. ST segment was also restored with the treatment of HQTBT. Triphenyltetrazole chloride (TTC) staining and pathological analysis showed that HQTBT reduced myocardial injury. Besides, the expressions of HMGB1/TLR/NF-B pathway in rats were significantly decreased by HQTBT. This study shows that HQTBT inhibited inflammatory reaction on myocardial injury in rats.
C1 [Liu, Kun; You, Qing-sheng; Wang, Fei; Wang, Shuo; Ma, Chun-Hui; Li, Wei-Nan] Nantong Univ, Dept Cardiothorac Surg, Affiliated Hosp, Nantong, Peoples R China.
   [Li, Manman] China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210009, Peoples R China.
   [Ren, Xiumei] Nantong Univ, Dept Tradit Chinese Med, Affiliated Hosp, Nantong, Peoples R China.
   [Ye, Qing] Nantong Univ, Dept Obstet & Gynecol, Affiliated Hosp, Nantong, Peoples R China.
C3 Nantong University; China Pharmaceutical University; Nantong University;
   Nantong University
RP Ye, Q (corresponding author), Nantong Univ, Dept Obstet & Gynecol, Affiliated Hosp, Nantong, Peoples R China.
EM jsntyeqing001@sina.com
RI Li, Manman/AGP-3086-2022
FU Six Talent Peaks Project in Jiangsu Province [2014-YY-006]; China
   Postdoctoral Science Foundation [2013M541705]; Jiangsu Postdoctoral
   Research Foundation [1301072C]; Science Foundation of Nantong City,
   Jiangsu Province, China [MS32015016]
FX This work was supported by grants from the Six Talent Peaks Project in
   Jiangsu Province (no. 2014-YY-006), the China Postdoctoral Science
   Foundation (no. 2013M541705), the Jiangsu Postdoctoral Research
   Foundation (no. 1301072C), and the Science Foundation of Nantong City,
   Jiangsu Province, China (no. MS32015016).
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NR 16
TC 17
Z9 21
U1 0
U2 12
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0962-9351
EI 1466-1861
J9 MEDIAT INFLAMM
JI Mediat. Inflamm.
PY 2019
VL 2019
AR 8387636
DI 10.1155/2019/8387636
PG 9
WC Cell Biology; Immunology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Immunology
GA HP5EF
UT WOS:000461699100001
PM 30944548
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Mendonça, BS
   Nascimento, LMM
   Ferro, JND
   Reis, MDD
AF Mendonca, Beatriz Santana
   Nascimento, Laura Maria Morales
   de Souza Ferro, Jamylle Nunes
   dos Santos Reis, Maria Danielma
TI The effect of plant-derived polyphenols on the immune system during
   aging: a systematic review
SO IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
LA English
DT Review
DE Phenolic compounds; senescence/aging; immune system; immune response;
   natural products
ID COGNITIVE IMPAIRMENT; SENESCENT CELLS; DIETARY-INTAKE; RESVERATROL;
   SALIDROSIDE; MOLECULE; CURCUMIN; THYMUS; DAMAGE; MICE
AB ObjectivePolyphenols are organic compounds with diverse biological activities such as anti-inflammatory and antioxidant effects, making them important candidates for the development of anti-aging drugs. In this systematic review, we aimed to answer the question: can plant-derived polyphenols have an immunomodulatory effect in experimental models of aging?MethodsWe systematically searched Web of Science, MEDLINE/Pubmed, and Embase to select articles using the following combinations of terms and synonyms: polyphenols, phenols, senescence, aging, and immune. The selected articles were evaluated for reporting quality and risk-of-bias according to standard guidelines.ResultsThe most used polyphenol was resveratrol, followed by curcumin, salidroside, and gallic acid. These molecules demonstrated an ability to restore immune function both in vitro and in vivo. The mechanism of action was not completely elucidated in these studies, but inhibition of NF-kB signaling, and antioxidant properties seemed to account for the anti-aging effects. All articles included in the review had good quality of reporting but failed to describe an adequate sample size, criteria for inclusion/exclusion, randomization, and blinding.ConclusionWe conclude that polyphenols are promising immunomodulatory substances for use in anti-aging therapies. However, more research with standardized analysis is needed to understand the role of these molecules in the prevention or reduction of damage associated with the aging process, as well as to determine the safety profile and consequences of systemic action.
C1 [Mendonca, Beatriz Santana; Nascimento, Laura Maria Morales; de Souza Ferro, Jamylle Nunes; dos Santos Reis, Maria Danielma] Univ Fed Alagoas, Inst Hlth & Biol Sci, Lab Cell Biol, Maceio, Brazil.
C3 Universidade Federal de Alagoas
RP Reis, MDD (corresponding author), Univ Fed Alagoas, Inst Biol & Hlth Sci, Lab Cell Biol, Ave Lourival Melo Mota S-N, BR-57072970 Maceio, Alagoas, Brazil.
EM danielma.reis@icbs.ufal.br
RI ; dos Santos Reis, Maria/S-7334-2019
OI Nunes de Souza Ferro, Jamylle/0000-0002-2600-9316; 
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NR 51
TC 2
Z9 2
U1 2
U2 26
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0892-3973
EI 1532-2513
J9 IMMUNOPHARM IMMUNOT
JI Immunopharmacol. Immunotoxicol.
PD SEP 2
PY 2024
VL 46
IS 5
BP 604
EP 617
DI 10.1080/08923973.2024.2384911
EA JUL 2024
PG 14
WC Immunology; Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy; Toxicology
GA G7U1B
UT WOS:001279426200001
PM 39069754
DA 2026-05-27
ER

PT J
AU Yu, S
   Liu, X
   Shen, YT
   Xu, H
   Yang, YM
   Ding, F
AF Yu, Shu
   Liu, Xin
   Shen, Yuntian
   Xu, Hui
   Yang, Yumin
   Ding, Fei
TI THERAPEUTIC BENEFITS OF COMBINED TREATMENT WITH TISSUE PLASMINOGEN
   ACTIVATOR AND
   2-(4-METHOXYPHENYL)ETHYL-2-ACETAMIDO-2-DEOXY-β-D-PYRANOSIDE IN AN ANIMAL
   MODEL OF ISCHEMIC STROKE
SO NEUROSCIENCE
LA English
DT Article
DE 2-(4-methoxyphenyl)ethyl-2-acetamido-2-deoxy-beta-D-pyranoside; tissue
   plasminogen activator; ischemic stroke; thrombolytic therapy;
   neuroprotection
ID INTRAVENOUS ALTEPLASE; CEREBRAL-ISCHEMIA; RAT MODEL; DAMAGE;
   THROMBOLYSIS; SALIDROSIDE; PROTECTS; EFFICACY; GLUCOSE; SAFETY
AB Tissue plasminogen activator (tPA) is the only approved therapy for acute ischemic stroke, but tPA therapy is limited by a short therapeutic window and some adverse side effects. 2-(4-Methoxyphenyl) ethyl-2-acetamido-2-deoxy-b-beta-pyranoside, a salidroside analog (code-named SalA-4g), has shown potent neuroprotective effects. In this study, a rat model of embolic middle cerebral artery occlusion (MCAO) was used to mimic ischemic stroke. The embolic MCAO rats were intravenously (iv) injectedwith tPA alone, SalA-4g alone, or a combination of tPA and SalA-4g. Compared to treatment with tPA alone at 4 h post MCAO, combined treatment with tPA at 4 h post MCAO and SalA-4g starting at 4 h post MCAO and continuing for 3 days at an interval of 24 h significantly reduced neurological deficits and infarct volume, and significantly inhibited the intracerebral bleeding, edema formation, neuronal loss, and cellular apoptosis in the ischemic brain. Our results suggested that additive neuroprotective actions of SalA-4g contributed to widening the therapeutic window of tPA therapy and ameliorating its side effects in treating MCAO rats. The therapeutic benefits of combined treatment with tPA and SalA-4g for ischemic stroke might be associated with its effects on cerebral glucose metabolism. (C) 2016 IBRO. Published by Elsevier Ltd. All rights reserved.
C1 [Yu, Shu; Liu, Xin; Shen, Yuntian; Xu, Hui; Yang, Yumin; Ding, Fei] Nantong Univ, Collaborat Innovat Ctr Neuroregenerat, Jiangsu Key Lab Neuroregenerat, 19 Qixiu Rd, Nantong 226001, JS, Peoples R China.
C3 Nantong University
RP Ding, F (corresponding author), Nantong Univ, Collaborat Innovat Ctr Neuroregenerat, Jiangsu Key Lab Neuroregenerat, 19 Qixiu Rd, Nantong 226001, JS, Peoples R China.
EM dingfei@ntu.edu.cn
RI Shen, Yuntian/GPX-9670-2022; DING, FEI/KLD-8925-2024
OI Yu, Shu/0000-0003-3771-267X
FU National Key Basic Research Program of China (973 program)
   [2014CB542203]; National Natural Science Foundation of China [81401094,
   81371389]; Natural Science Research Project of Nantong Science and
   Technology Bureau [HS2013014]; Natural Science Research Project of
   Nantong University [13ZY009]; Priority Academic Program Development of
   Jiangsu Higher Education Institutions (PAPD)
FX We thank the researchers at the Department of Nuclear Medicine, Fudan
   University Shanghai Cancer Center, the Department of Oncology, Shanghai
   Medical College, Fudan University, Center for Biomedical Imaging, Fudan
   University, and Shanghai Engineering Research Center for Molecular
   Imaging Probes for their help in performing 18F-FDG PET/CT.
   We thank Professor Jie Liu for assistance in manuscript preparation.
   This work was supported by the National Key Basic Research Program of
   China (973 program, Grant No. 2014CB542203), National Natural Science
   Foundation of China (Grant Nos. 81401094 and 81371389), Natural Science
   Research Project of Nantong Science and Technology Bureau (HS2013014),
   Natural Science Research Project of Nantong University (Grant No.
   13ZY009), and a Project Funded by the Priority Academic Program
   Development of Jiangsu Higher Education Institutions (PAPD).
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NR 39
TC 10
Z9 11
U1 1
U2 21
PU PERGAMON-ELSEVIER SCIENCE LTD
PI OXFORD
PA THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, ENGLAND
SN 0306-4522
EI 1873-7544
J9 NEUROSCIENCE
JI Neuroscience
PD JUL 7
PY 2016
VL 327
BP 44
EP 52
DI 10.1016/j.neuroscience.2016.04.006
PG 9
WC Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Neurosciences & Neurology
GA DL2SW
UT WOS:000375486500005
PM 27060484
DA 2026-05-27
ER

PT J
AU Liu, LL
   Chen, J
   Liu, Y
   Hou, QL
   Shao, JH
   Zhao, CC
AF Liu, Lin-Lin
   Chen, Jia
   Liu, Yang
   Hou, Qi-Long
   Shao, Jian-Hua
   Zhao, Chun-Chao
TI A New Phenolic Glycoside with Aldose Reductase Inhibitory Activity from
   Eucommia ulmoides
SO CHEMISTRY OF NATURAL COMPOUNDS
LA English
DT Article
DE Eucommiaceae; Eucommia ulmoides; phenolic glycoside; aldose reductase
   inhibition
AB A new phenolic glycoside 1 and three known compounds (2-4) have been isolated from the 95% ethanolic extract of Eucommia ulmoides Oliv. leaves. Their structures were identified as erythro-1-O-methyl-2-O-beta-D-glucopyranosyl-guaiacylglycerol (1), 3,5-dimethoxybenzyl alcohol 4-O-beta-D-glucopyranoside (2), salidroside (3), and dihydroconiferin (4) from spectroscopic data (H-1 NMR, C-13 NMR, HSQC, and HMBC) and using chemical methods. In the in vitro assay, compound 1 displayed potent inhibitory activity against aldose reductase with an IC50 value of 7.82 mu M.
C1 [Liu, Lin-Lin; Chen, Jia; Liu, Yang; Hou, Qi-Long; Shao, Jian-Hua; Zhao, Chun-Chao] Yangzhou Univ, Coinnovat Ctr Modern Prod Technol Grain Crops, Jiangsu Key Lab Crop Genet & Physiol, Yangzhou 225009, Jiangsu, Peoples R China.
C3 Yangzhou University
RP Shao, JH (corresponding author), Yangzhou Univ, Coinnovat Ctr Modern Prod Technol Grain Crops, Jiangsu Key Lab Crop Genet & Physiol, Yangzhou 225009, Jiangsu, Peoples R China.
EM jhuashao@yzu.edu.cn
RI zhao, chunchao/AAU-8036-2021; Liu, Linlin/GWR-3563-2022
FU National Natural Science Foundation of China [31201563]; Top-notch
   Academic Programs Project of Jiangsu Higher Education Institutions
   [C202011117006Z/202011117004Z]
FX This work was supported by the National Natural Science Foundation of
   China (No. 31201563) and the Top-notch Academic Programs Project of
   Jiangsu Higher Education Institutions (C202011117006Z/202011117004Z). We
   are also grateful to Prof. Huyin Huai, College of Bioscience and
   Biotechnology, Yangzhou University, for the identification of the plant.
CR Chen J, 2017, CHEM NAT COMPD+, V53, P254, DOI 10.1007/s10600-017-1964-9
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NR 9
TC 4
Z9 4
U1 2
U2 29
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0009-3130
EI 1573-8388
J9 CHEM NAT COMPD+
JI Chem. Nat. Compd.
PD JAN
PY 2021
VL 57
IS 1
BP 47
EP 49
DI 10.1007/s10600-021-03278-1
EA JAN 2021
PG 3
WC Chemistry, Medicinal; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED); Index Chemicus (IC)
SC Pharmacology & Pharmacy; Chemistry
GA QC4PB
UT WOS:000609974300015
DA 2026-05-27
ER

PT J
AU Xue, S
   Xu, YM
   Xu, SL
   Zhong, YM
   Ruan, GF
   Ma, JZ
   Hu, Y
   Ding, CH
   Sang, WL
AF Xue, Song
   Xu, Yiming
   Xu, Shenglin
   Zhong, Yiming
   Ruan, Guangfeng
   Ma, Jinzhong
   Hu, Yong
   Ding, Changhai
   Sang, Weilin
TI Mitophagy impairment mediates the pathogenesis of CoCrMo
   particle-induced osteolysis via NLRP3/caspase-1/GSDMD-dependent
   pyroptosis in macrophages
SO CHEMICAL ENGINEERING JOURNAL
LA English
DT Article
DE CoCrMo; Osteoclastogenesis; Mitophagy; Reactive oxygen species;
   Pyroptosis
ID INDUCED BONE LOSS; NLRP3 INFLAMMASOME; IN-VITRO; ACTIVATION; APOPTOSIS;
   CELLS; SALIDROSIDE; OSTEOBLAST; STRESS; TARGET
AB Wear particles derived from implant surfaces are the important factors causing periprosthetic osteolysis (PPO), which is the main reason for total joint revision. To date, the specific pathogenesis of PPO remains largely unknown, and developing new therapeutic strategies is urgently necessary. Our study indicated the most clinically common cobalt-chromium-molybdenum (CoCrMo) wear particles (CoPs) activated macrophages and further accelerated osteoclastogenesis. Subsequently, we put emphasis on the pathologic change in macrophages after CoPs stimulation. Meaningfully, high-concentration CoPs induced reactive oxygen species (ROS) accumulation in macrophages and activated NOD-like receptor pyrin domain-containing 3 (NLRP3)-dependent pyroptosis, promoting the release of cytokines such as IL-18, IL-1 beta and HMGB1, and subsequent formation of extracellular inflammatory microenvironment, which is crucial for osteoclastogenesis. More interestingly, transmission electron microscopy and flow cytometry results revealed that there were accumulation of endamaged mitochondria in high-concentration CoP-challenged macrophages, which accelerated intracellular ROS accumulation and mediated NLRP3-dependent pyroptosis. Mechanismly, high-concentration CoPs induced macrophage mitophagy impairment and the loss of mitochondrial membrane potential via inhibiting PINK1/Parkin signalling pathway. Furthermore, by subcutaneous injection of salidroside and/or CY-09 in situ significantly delayed CoP-induced mice calvaria osteolysis. Collectively, this study demonstrates a novel mechanism underlying the pathogenesis of PPO and provides a potential therapy avenue.
C1 [Xue, Song; Ding, Changhai] Anhui Med Univ, Arthrit Res Inst, Dept Rheumatol & Immunol, Affiliated Hosp 1, Hefei, Peoples R China.
   [Xu, Yiming; Zhong, Yiming; Ma, Jinzhong; Sang, Weilin] Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Orthoped, Sch Med, Shanghai, Peoples R China.
   [Xu, Shenglin; Hu, Yong] Anhui Med Univ, Dept Orthoped, Affiliated Hosp 1, Hefei, Peoples R China.
   [Ding, Changhai] Southern Med Univ, Zhujiang Hosp, Clin Res Ctr, Guangzhou, Peoples R China.
   [Ding, Changhai] Univ Tasmania, Menzies Inst Med Res, Hobart, Tas, Australia.
   [Ruan, Guangfeng] South China Univ Technol, Guangzhou Peoples Hosp 1, Clin Res Ctr, Sch Med, Guangzhou, Peoples R China.
C3 Anhui Medical University; Shanghai Jiao Tong University; Anhui Medical
   University; Southern Medical University - China; University of Tasmania;
   Menzies Institute for Medical Research; South China University of
   Technology
RP Ding, CH (corresponding author), Anhui Med Univ, Arthrit Res Inst, Dept Rheumatol & Immunol, Affiliated Hosp 1, Hefei, Peoples R China.; Sang, WL (corresponding author), Shanghai Jiao Tong Univ, Shanghai Gen Hosp, Dept Orthoped, Sch Med, Shanghai, Peoples R China.; Hu, Y (corresponding author), Anhui Med Univ, Dept Orthoped, Affiliated Hosp 1, Hefei, Peoples R China.
EM 526597676@qq.com; changhai.ding@utas.edu.au; Sang_weilin@163.com
OI RUAN, GUANGFENG/0000-0002-1471-7358; Xue, Song/0000-0002-2932-5488;
   Zhong, Yiming/0000-0001-8832-2458
FU National Natural Science of China [81974342, 81871795, 8217090554];
   Shanghai Municipal Health Commission Clinical Research project
   [202040446]; Medical Engineering Cross Research Project [YG2019QNB37];
   Songjiang District Science and Technology Research project [19SJKJGG13];
   Program for Upgrading Basic and Clinical Collaborative Research of Anhui
   Medical University [2020xkjT033]; Major Projects of Natural Science
   Foundation of Universities in Anhui Province [KJ2020ZD17]; Graduate
   Scientific Research Project of Anhui Province [YJS20210272]
FX This study was funded by the National Natural Science of China (No.
   81974342, No. 81871795 and No. 8217090554) , Shanghai Municipal Health
   Commission Clinical Research project (No. 202040446) , Medical
   Engineering Cross Research Project of (YG2019QNB37) , Songjiang District
   Science and Technology Research project (19SJKJGG13) , Pro-gram for
   Upgrading Basic and Clinical Collaborative Research of Anhui Medical
   University (2020xkjT033) , Major Projects of Natural Science Foundation
   of Universities in Anhui Province (KJ2020ZD17) and Graduate Scientific
   Research Project of Anhui Province (YJS20210272) . We would like to
   thank the Home for Researchers ( www.home-for-re-searchers.com ) for
   providing powerful technical support.
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NR 60
TC 16
Z9 17
U1 3
U2 93
PU ELSEVIER SCIENCE SA
PI LAUSANNE
PA PO BOX 564, 1001 LAUSANNE, SWITZERLAND
SN 1385-8947
EI 1873-3212
J9 CHEM ENG J
JI Chem. Eng. J.
PD MAY 1
PY 2022
VL 435
AR 135115
DI 10.1016/j.cej.2022.135115
EA FEB 2022
PN 2
PG 16
WC Engineering, Environmental; Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA ZZ0LQ
UT WOS:000772968800003
DA 2026-05-27
ER

PT J
AU Zduriencikova, M
   Cholujova, D
   Duraj, J
   Mastihubova, M
   Mastihuba, V
   Potocka, EK
   Galova, E
   Sevcovicova, A
   Klapakova, M
   Horvathova, E
AF Zduriencikova, Martina
   Cholujova, Dana
   Duraj, Jozef
   Mastihubova, Maria
   Mastihuba, Vladimir
   Potocka, Elena Karnisova
   Galova, Eliska
   Sevcovicova, Andrea
   Klapakova, Martina
   Horvathova, Eva
TI Salidroside, a Chemopreventive Glycoside, Diminishes Cytotoxic Effect of
   Cisplatin in Vitro
SO BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
LA English
DT Article
ID CANCER CELL-LINES; PHENYLETHANOID GLYCOSIDES; ESSENTIAL OIL; DNA;
   ANTIOXIDANT; INDUCTION; MODULATION; CARVACROL; APOPTOSIS; EXTRACTS
AB Natural products represent the source or the inspiration for the majority of the active ingredients of medicines because of their structural diversity and a wide range of biological effects. Our aims inthis study were (i) to synthesize enzymatically salidroside (SAL), the most effective phenylethanoid glycoside in Rhodiola species; (ii) to examine its antioxidant capacity using cell-free assays (reducing power, DPPH radicals scavenging and Fe2+-chelating assays); (iii) to assess its DNA-protective potential on plasmid DNA (DNA topology assay) and in HepG2 cells (comet assay) damaged by Fe2+ ions and hydrogen peroxide, respectively; and (iv) to investigate the effects of SAL, cisplatin (CDDP) and combined treatments of SAL+CDDP on cell viability (MTT test), level of DNA damage (comet assay), proliferation, cell cycle (flow cytometry) and the expression of signalling molecules associated with cell growth and apoptotic pathways (Western immunoblotting). We found out that SAL manifested low antioxidant and DNA-protective capacity in all assays used. In both parental A2780 and CDDP-resistant A2780/CP human ovarian carcinoma cells, SAL itself exerted in fact no impact on the viability, while in combination with CDDP it showed antagonistic effect supporting the chemopreventive activity on the CDDP-induced cell damage. These results were confirmed by the partial reversal of the cell cycle alterations and the DNA damage level, as well as with partial restoration of cell survival/signalling pathways, when the expression of these molecules partially returned to their proper levels.
C1 [Zduriencikova, Martina; Cholujova, Dana; Duraj, Jozef; Horvathova, Eva] Slovak Acad Sci, Canc Res Inst BMC, Dubravska Cesta 9, Bratislava 84505, Slovakia.
   [Mastihubova, Maria; Mastihuba, Vladimir; Potocka, Elena Karnisova] Slovak Acad Sci, Inst Chem, Bratislava, Slovakia.
   [Galova, Eliska; Sevcovicova, Andrea; Klapakova, Martina] Comenius Univ, Dept Genet, Fac Nat Sci, Bratislava, Slovakia.
C3 Slovak Academy of Sciences; Slovak Academy of Sciences; Institute of
   Chemistry, SAS; Comenius University Bratislava
RP Horvathova, E (corresponding author), Slovak Acad Sci, Canc Res Inst BMC, Dubravska Cesta 9, Bratislava 84505, Slovakia.
EM Eva.Horvathova@savba.sk
RI Karnišová Potocká, Elena/AAU-9718-2021; Horvathova, Eva/B-8638-2019;
   Mastihubova, Maria/OZG-0746-2025; Cholujova, Dana/AAD-1723-2019; Gálová,
   Eliška/AAE-7043-2021; Mastihuba, Vladimír/S-7938-2017; Sevcovicova,
   Andrea/N-9253-2018
OI Karnišová Potocká, Elena/0000-0003-1546-4134; Horvathova,
   Eva/0000-0003-1496-5922; Mastihubova, Maria/0000-0003-3033-811X;
   Cholujova, Dana/0000-0003-4024-7713; Gálová, Eliška/0000-0003-3494-4432;
   Mastihuba, Vladimír/0000-0003-2587-2553; Sevcovicova,
   Andrea/0000-0003-2912-5184
FU Slovak Research and Development Agency [APVV-0846-12]; Scientific Grant
   Agency of the Ministry of Education of Slovak Republic; Academy of
   Sciences [VEGA 2/0084/16, 2/0157/16]; TRANSMED, Research & Development
   Operational Programme - ERDF [ITMS: 26240120008, ITMS: 26240220071]
FX The authors thank Jan Sedlak, DSc. (Cancer Research Institute BMC SAS,
   Bratislava) for complex and extensive expertise and elucidation of our
   manuscript and Bozena Smolkova, PhD (Cancer Research Institute BMC SAS,
   Bratislava) for her assistance with the statistical analysis of our
   results. They are also thankful to Mrs. Margita Sulikova, Anna Moravkova
   and Gertruda Huskova for excellent technical assistance. This study was
   supported by the Slovak Research and Development Agency Grant
   APVV-0846-12, Scientific Grant Agency of the Ministry of Education of
   Slovak Republic and the Academy of Sciences Grants VEGA 2/0084/16,
   2/0157/16 and the project implementations: TRANSMED, ITMS: 26240120008
   and ITMS: 26240220071 supported by the Research & Development
   Operational Programme funded by the ERDF.
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NR 36
TC 7
Z9 7
U1 1
U2 22
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 1742-7835
EI 1742-7843
J9 BASIC CLIN PHARMACOL
JI Basic Clin. Pharmacol. Toxicol.
PD MAR
PY 2018
VL 122
IS 3
BP 346
EP 354
DI 10.1111/bcpt.12906
PG 9
WC Pharmacology & Pharmacy; Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy; Toxicology
GA FV9CC
UT WOS:000424883300007
PM 28889522
OA Bronze
DA 2026-05-27
ER

PT J
AU Pei, DL
   Tian, SR
   Bao, YQ
   Zhang, J
   Xu, DY
   Piao, MH
AF Pei, Delong
   Tian, Shengri
   Bao, Yanqiu
   Zhang, Jun
   Xu, Dongyuan
   Piao, Minhu
TI Protective effect of salidroside on streptozotocin-induced diabetic
   nephropathy by inhibiting oxidative stress and inflammation in rats via
   the Akt/GSK-3β signalling pathway
SO PHARMACEUTICAL BIOLOGY
LA English
DT Article
DE Anti-inflammatory; antidiabetic; Rhodiola rosea
ID INDUCED APOPTOSIS; ACTIVATION; ALPHA; CELLS; MODEL
AB Context Salidroside (SAL), one of the major glycosides isolated from the roots of Rhodiola rosea L. (Crassulaceae), has anti-inflammatory, antioxidant, and antidiabetic properties. Objective Our study assessed whether SAL exerts a protective effect on streptozotocin (STZ)-induced diabetic nephropathy (DN) in rats via the Akt/GSK-3 beta signalling pathway. Materials and methods Adult male Wistar rats were divided into three groups (n = 8): normal control, DN + vehicle, and DN + SAL. SAL (50 mg/kg/day, oral) was administered for 8 weeks. Biochemical and histopathologic examinations were performed to evaluate the therapeutic effects of SAL on oxidative stress, inflammation, renal function, and apoptosis. Results SAL induced rats demonstrated ameliorated levels of FBG (20.53 +/- 0.72 mmol/L vs. 26.02 +/- 1.44 mmol/L), urine albumin excretion (27.00 +/- 1.46 mmol/L vs. 41.00 +/- 1.59 mmol/L), blood urea nitrogen (14.42 +/- 0.70 mmol/L vs. 17.77 +/- 0.72 mmol/L), and serum creatinine (112.80 +/- 6.98 mmol/L vs. 159.00 +/- 3.81 mmol/L) compared to normal control rats, along with the alleviation of renal pathologic changes by improving the irregular shape of glomeruli tissues. Biochemical analysis showed that SAL-treated animals displayed suppressed levels of serum inflammatory cytokines and kidney oxidative stress markers and attenuated apoptotic characteristics. Moreover, it increased the phosphorylation levels of Akt and GSK-3 beta in kidneys. Discussion and conclusion The present study validated the involvement of the Akt/GSK-3 beta signalling pathway in renal improvement. These findings can form the basis to investigate the protective effect of SAL in DN in clinical trials.
C1 [Pei, Delong; Tian, Shengri; Piao, Minhu] Yanbian Univ, Dept Urol, Affiliated Hosp, Yanji 133000, Jilin, Peoples R China.
   [Bao, Yanqiu; Zhang, Jun; Xu, Dongyuan] Yanbian Univ, Ctr Morphol Expt, Med Coll, Yanji 133000, Jilin, Peoples R China.
C3 Yanbian University; Yanbian University
RP Piao, MH (corresponding author), Yanbian Univ, Dept Urol, Affiliated Hosp, Yanji 133000, Jilin, Peoples R China.; Xu, DY (corresponding author), Yanbian Univ, Ctr Morphol Expt, Med Coll, Yanji 133000, Jilin, Peoples R China.
EM dyxu@ybu.edu.cn; piaominhu99@163.com
FU Natural Science Research Foundation of Jilin Province for Sciences and
   Technology [20200201575JC]
FX This work was supported by the Natural Science Research Foundation of
   Jilin Province for Sciences and Technology [20200201575JC].
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NR 26
TC 18
Z9 25
U1 0
U2 25
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1388-0209
EI 1744-5116
J9 PHARM BIOL
JI Pharm. Biol.
PD DEC 31
PY 2022
VL 60
IS 1
BP 1732
EP 1738
DI 10.1080/13880209.2022.2116055
PG 7
WC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Medical Laboratory Technology; Pharmacology & Pharmacy
GA 4L5JS
UT WOS:000852667000001
PM 36086879
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Carrero-Carralero, C
   Rodríguez-Sánchez, S
   Calvillo, I
   Martinez-Castro, I
   Soria, AC
   Ramos, L
   Sanz, ML
AF Carrero-Carralero, C.
   Rodriguez-Sanchez, S.
   Calvillo, I
   Martinez-Castro, I
   Soria, A. C.
   Ramos, L.
   Sanz, M. L.
TI Gas chromatographic-based techniques for the characterization of low
   molecular weight carbohydrates and phenylalkanoid glycosides of Sedum
   roseum root supplements
SO JOURNAL OF CHROMATOGRAPHY A
LA English
DT Article
DE Rhodiola rosea; Sedum roseum; Gas chromatography-mass spectrometry
   (GC-MS); Comprehensive two-dimensional gas chromatography coupled to
   time-of-flight mass spectrometry (GC x GC-ToF MS); Phenylalkanoid
   glycosides; Carbohydrates
ID RHODIOLA-ROSEA L.; LIQUID-CHROMATOGRAPHY; BIOLOGICAL-ACTIVITY;
   MASS-SPECTROMETRY; PLANTS; SALIDROSIDE; IDENTIFICATION; PRODUCTS;
   EXTRACTS; ROSAVIN
AB An extensive characterization of low molecular weight carbohydrates (LMWC) and phenylalkanoid glycosides (PAG) of Sedum roseum root supplements has been carried out for the first time by gas chromatography coupled to mass spectrometry (GC-MS) and by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry (GC x GC-ToF MS). Optimization of the required derivatization procedure for improved determination of PAG showed the combined use of trimethylsilylimidazole and trimethylchlorosilane as the most appropriate reagents. Up to 37 compounds were qualitative- and quantitatively characterized in different dietary supplements of S. roseum by GC-MS. In addition to the well-known rosin, rosarin, rosavin and salidroside, other carbohydrates, polyalcohols, acids, etc. were determined. Among them, several seven-carbon monosaccharides such as coriose and 2,7-anhydro-beta-D-altro-heptulose were detected for the first time in S. roseum root supplements. Sedoheptulose was found to be the most abundant compound (9-151 mg g(-1)), followed by rosiridin (20-81 mg g(-1)) and rosavin (11-56 mg g(-1)). The use of GC x GC-ToF MS allowed the detection and tentative assignation of 48 additional compounds mainly belonging to the phenylalkanoid glycoside, pentosyl-hexose and hexosyl-hexose families. (C) 2018 Elsevier B.V. All rights reserved.
C1 [Carrero-Carralero, C.; Rodriguez-Sanchez, S.; Calvillo, I; Martinez-Castro, I; Soria, A. C.; Ramos, L.; Sanz, M. L.] CSIC, Inst Quim Organ Gen, Juan Cierva 3, Madrid 28006, Spain.
   [Rodriguez-Sanchez, S.] CSIC, MNCN, Serrano 115-B, Madrid 28006, Spain.
C3 Consejo Superior de Investigaciones Cientificas (CSIC); CSIC - Instituto
   de Quimica Organica General (IQOG); Consejo Superior de Investigaciones
   Cientificas (CSIC)
RP Sanz, ML (corresponding author), CSIC, Inst Quim Organ Gen, Juan Cierva 3, Madrid 28006, Spain.
EM mlsanz@iqog.csic.es
RI Ramos, Lourdes/B-6432-2015; Soria, Ana Cristina/H-8962-2015;
   Carrero-Carralero, Cipriano/HLX-0467-2023; Sanz, María Luz/G-3815-2011
OI Ramos, Lourdes/0000-0003-1842-3995; Soria, Ana
   Cristina/0000-0001-8045-3883; Carrero-Carralero,
   Cipriano/0000-0002-4545-3316; Sanz, María Luz/0000-0002-8156-4734;
   Rodriguez-Sanchez, Sonia/0009-0005-4459-5426
FU Fundacion Ramon Areces [CIVP17A2843]; Comunidad Autonoma of Madrid
   [S2013/ABI-3028]; European funding from FEDER program [S2013/ABI-3028];
   Ministerio de Economia, Industria y Competitividad (MINEICO) of Spain
   [AGL2016-80475-R]
FX This work has been funded by Fundacion Ramon Areces (project
   CIVP17A2843), by Comunidad Autonoma of Madrid and European funding from
   FEDER program (project S2013/ABI-3028, AVANSE-CAL) and by Ministerio de
   Economia, Industria y Competitividad (MINEICO) of Spain (project
   AGL2016-80475-R, AEI/FEDER, UE). C.C.C. thanks MINECO for a predoctoral
   contract. Authors also thank Dr. R. Morales (CSIC) for kindly providing
   Coriaria sp. leaf samples and Mr. S. Rivas for his technical assistance.
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NR 36
TC 6
Z9 6
U1 1
U2 31
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0021-9673
EI 1873-3778
J9 J CHROMATOGR A
JI J. Chromatogr. A
PD OCT 5
PY 2018
VL 1570
BP 116
EP 125
DI 10.1016/j.chroma.2018.07.071
PG 10
WC Biochemical Research Methods; Chemistry, Analytical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GV3GM
UT WOS:000445982400014
PM 30098734
DA 2026-05-27
ER

PT J
AU Li, FL
   Xiao, FR
   Gong, JL
   Yu, T
AF Li, Fenglin
   Xiao, Furen
   Gong, Jingli
   Yu, Tian
TI APPLIED ORTHOGONAL EXPERIMENT DESIGN FOR THE OPTIMUM MICROWAVE-ASSISTED
   EXTRACTION CONDITIONS OF POLYSACCHARIDES FROM RHODIOLAE RADIX
SO AFRICAN JOURNAL OF TRADITIONAL COMPLEMENTARY AND ALTERNATIVE MEDICINES
LA English
DT Article
DE Rhodiolae Radix; polysaccharides; orthogonal experiment design;
   microwave-assisted extraction
ID SACHALINENSIS; SALIDROSIDE
AB An experiment on polysaccharides from Rhodiolae Radix (PRR) extraction was carried out using microwave-assisted extraction (MAE) method with an objective to establishing the optimum MAE conditions of PRR. Single factor experiments were performed to determine the appropriate range of extraction conditions, and the optimum conditions were obtained using orthogonal experiment design. The results showed that the optimum MAE conditions of PRR were as follows: solid-liquid ratio of 1:45 g/mL, irradiation power of 480 W, and irradiation time of 8 min, while extraction yield of PRR was 3.24%.
C1 [Li, Fenglin; Gong, Jingli; Yu, Tian] Jilin Agr Sci & Technol Coll, Jilin 132101, Peoples R China.
   [Li, Fenglin; Gong, Jingli] Brewing Technol Innovat Ctr Jilin Prov, Jilin 132101, Peoples R China.
   [Li, Fenglin; Xiao, Furen] Yanshan Univ, Coll Mat Sci & Engn, Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Peoples R China.
C3 Jilin Agricultural Science & Technology University; Yanshan University
RP Li, FL (corresponding author), Jilin Agr Sci & Technol Coll, Jilin 132101, Peoples R China.
EM swgclfl@163.com
RI Li, Fenglin/NYS-8823-2025
FU Science and Technology Development Foundation of Jilin Province of China
   [20120918]; Reserve Foundation of Jilin Agricultural Science and
   Technology College [2012-409]
FX This work was supported by the Science and Technology Development
   Foundation of Jilin Province of China (Grant No. 20120918) and Reserve
   Foundation of Jilin Agricultural Science and Technology College (Grant
   No. 2012-409).
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NR 19
TC 9
Z9 9
U1 3
U2 43
PU AFRICAN NETWORKS ETHNOMEDICINES
PI ILE-IFE
PA OBAFEMI AWOLOWO UNIV,CLEMENT O ADEWUNMI, DRUG RES PROD UNIT, FAC
   PHARMACY, ILE-IFE, 00000, NIGERIA
SN 0189-6016
J9 AFR J TRADIT COMPLEM
JI Afr. J. Tradit. Complement. Alt. M.
PY 2013
VL 10
IS 4
BP 179
EP 185
DI 10.4314/ajtcam.v10i4.29
PG 7
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 203UE
UT WOS:000323318400029
PM 24146521
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Kapoor, S
   Sharma, A
   Bhardwaj, P
   Sood, H
   Saxena, S
   Chaurasia, OP
AF Kapoor, Sahil
   Sharma, Ankita
   Bhardwaj, Pushpender
   Sood, Hemant
   Saxena, Shweta
   Chaurasia, Om Prakash
TI Enhanced Production of Phenolic Compounds in Compact Callus Aggregate
   Suspension Cultures of Rhodiola imbricata Edgew.
SO APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
LA English
DT Article
DE Rhodiola imbricata; Compact callus aggregate; Phenolic compounds;
   Jasmonic acid; Antioxidant; Antimicrobial
ID PLANT-GROWTH REGULATORS; HAIRY ROOT CULTURES; JASMONIC ACID;
   CELL-CULTURES; CATHARANTHUS-ROSEUS; AQUEOUS EXTRACT; ANTIOXIDANT
   CAPACITIES; SIGNAL-TRANSDUCTION; HYDROGEN-PEROXIDE; ROSMARINIC ACID
AB Rhodiola imbricata is a rare medicinal plant of the trans-Himalayan region of Ladakh. It is used for the treatment of numerous health ailments. Compact callus aggregate (CCA) suspension cultures of Rhodiola imbricata were established to counter extinction threats and for production of therapeutically valuable phenolic compounds to meet their increasing industrial demands. The present study also investigated the effect of jasmonic acid (JA) on production of phenolic compounds and bioactivities in CCA suspension cultures. CCA suspension cultures established in an optimized Murashige and Skoog medium supplemented with 30g/l sucrose, 3mg/l NAA, and 3mg/l BAP showed maximum biomass accumulation (8.43g/l DW) and highest salidroside production (3.37mg/g DW). Upon 100M JA treatment, salidroside production (5.25mg/g DW), total phenolic content (14.69mg CHA/g DW), total flavonoid content (4.95mg RE/g DW), and ascorbic acid content (17.93mg/g DW) were significantly increased in cultures. In addition, DPPH-scavenging activity (56.32%) and total antioxidant capacity (60.45mg QE/g DW) were significantly enhanced upon JA treatment, and this was positively correlated with increased accumulation of phenolic compounds. JA-elicited cultures exhibited highest antimicrobial activity against Escherichia coli. This is the first report describing the enhanced production of phenolic compounds and bioactivities from JA-elicited CCA suspension cultures of Rhodiola imbricata.
C1 [Kapoor, Sahil; Sharma, Ankita; Bhardwaj, Pushpender; Saxena, Shweta; Chaurasia, Om Prakash] Def Inst High Altitude Res DRDO, C-O 56 APO, Leh Ladakh 901205, Jammu & Kashmir, India.
   [Sood, Hemant] Jaypee Univ Informat Technol, Dept Biotechnol & Bioinformat, Solan 173215, Himachal Prades, India.
C3 Defence Research & Development Organisation (DRDO); Defence Institute of
   High Altitude Research (DIHAR); Jaypee University of Information
   Technology
RP Sood, H (corresponding author), Jaypee Univ Informat Technol, Dept Biotechnol & Bioinformat, Solan 173215, Himachal Prades, India.
EM hemant.sood2013@gmail.com
RI ; /AAL-3516-2021; Chaurasia, Om Prakash/AAP-3358-2021
OI , shweta/0000-0001-8171-4264; Kapoor, Sahil/0000-0002-1483-6760;
   Chaurasia, Om Prakash/0000-0003-2921-2755
FU Defence Research & Development Organization (DRDO), Ministry of Defence,
   Government of India
FX The authors wish to acknowledge Defence Research & Development
   Organization (DRDO), Ministry of Defence, Government of India, for
   financial support. Authors also wish to acknowledge Dr. Somen Acharya
   and Sc. 'C' Rajkumar for providing necessary facilities. The authors are
   also grateful to Rashmi Gupta for reviewing and copy-editing of the
   manuscript.
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NR 106
TC 18
Z9 21
U1 2
U2 23
PU SPRINGER
PI NEW YORK
PA 233 SPRING ST, NEW YORK, NY 10013 USA
SN 0273-2289
EI 1559-0291
J9 APPL BIOCHEM BIOTECH
JI Appl. Biochem. Biotechnol.
PD MAR
PY 2019
VL 187
IS 3
BP 817
EP 837
DI 10.1007/s12010-018-2851-y
PG 21
WC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biotechnology & Applied Microbiology
GA HS4NA
UT WOS:000463838900011
PM 30090988
DA 2026-05-27
ER

PT J
AU Wang, M
   Jin, X
   Ren, X
   Zhu, Y
   Liu, Z
   Gao, X
AF Wang, M.
   Jin, X.
   Ren, X.
   Zhu, Y.
   Liu, Z.
   Gao, X.
TI Comparative In Vitro Dissolution of Two Commercially Available
   Er-Zhi-Wan Herbal Medicinal Products
SO INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
LA English
DT Article
DE Er-Zhi-Wan; herbal medicinal products; UPLC; in vitro dissolution;
   quality control
ID FRUCTUS LIGUSTRI LUCIDI; PROFILES; EXTRACT; TABLETS; CELLS
AB In vitro dissolution test is an essential tool to assess the quality of herbal medicinal products in the solid dosage forms for oral use. Our work aimed to evaluate the dissolution behavior of Er-Zhi-Wan, in the formulations of water-honeyed pill and formula granule. Different media (water, 30% EtOH, 0.1 M HCl, acetate buffer, pH 4.5 and phosphate buffer, pH 6.8) were used following United States Pharmacopoeia and Chinese Pharmacopeia. An ultra-high performance liquid chromatography method was developed and validated to detect simultaneously six active ingredients for quantification and dissolution study (salidroside, specnuezhenide, nuezhenoside, luteolin, apigenin, oleanolic acid). As we observed, contents of main active ingredients were close in the two formulations for daily dose. In each medium, more ingredients dissolved from formula granule with higher Y-max and K-a. The mean dissolution time of the most ingredients in granule was significantly shorter than that in pill in acetate buffer, pH 4.5 and phosphate buffer, pH 6.8. Furthermore, salidroside, specnuezhenide and luteolin dissolved more than 80% in 30 min from formula granule, which indicated higher solubility along the intestinal tract according to biopharmaceutics classification system. The dissolution test developed and validated was adequate for its purposes and could be applied for quality control of herbal medicine. This work also can be used to provide necessary information on absorption for its biopharmaceutical properties.
C1 [Wang, M.; Jin, X.; Zhu, Y.; Liu, Z.; Gao, X.] Tianjin Univ Tradit Chinese Med, Minist Educ, Engn Res Ctr Modern Chinese Med Discovery & Prepa, Tianjin 300193, Peoples R China.
   [Ren, X.] Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 300193, Peoples R China.
C3 Tianjin University of Traditional Chinese Medicine; Tianjin University
   of Traditional Chinese Medicine
RP Ren, X (corresponding author), Tianjin Univ Tradit Chinese Med, Coll Tradit Chinese Med, Tianjin 300193, Peoples R China.
EM xiaoliang_ren@sina.com
RI Zhu, Yan/A-1548-2017
FU National Natural Science Foundation of China [81202851]; National
   Science Foundation for Distinguished Young Scholars of China [81125024];
   International Cooperation Project of Ministry of Science and Technology
   [2013DFA31620]
FX This work was financially supported by National Natural Science
   Foundation of China (Grant No. 81202851), the National Science
   Foundation for Distinguished Young Scholars of China (Grant No.
   81125024) and International Cooperation Project of Ministry of Science
   and Technology (Grant No. 2013DFA31620).
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U1 0
U2 26
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 0250-474X
EI 1998-3743
J9 INDIAN J PHARM SCI
JI Indian J. Pharm. Sci.
PD JUL-AUG
PY 2015
VL 77
IS 4
BP 391
EP 398
PG 8
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA CR8IW
UT WOS:000361595700004
PM 26664054
DA 2026-05-27
ER

PT J
AU Stepanova, AY
   Gladkov, EA
   Tereshonok, DV
   Selimov, RN
   Goncharova, EN
   Solov'eva, AI
AF Stepanova, Anna Y.
   Gladkov, Evgeny A.
   Tereshonok, Dmitry V.
   Selimov, Renat N.
   Goncharova, Elisaveta N.
   Solov'eva, Aleksandra I.
TI The Effect of Low Positive Temperatures on the Formation of Secondary
   Metabolites in Rhodiola quadrifida (Pall.) Fisch. et C.A. Mey. In
   Vitro Cultures
SO PROCESSES
LA English
DT Article
DE Rhodiola quadrifida; callus; hairy roots; salidroside; rosavin; rosarin;
   rosin; tyrosol
ID BIOLOGICALLY-ACTIVE COMPOUNDS; CINNAMYL ALCOHOL GLYCOSIDES; ROSEA L.;
   CALLUS-CULTURE; CELL-CULTURES; PLANTS; EXTRACTS; GROWTH; ROOTS; PART
AB Global warming is one of the most serious problems leading to changes in the distribution areas of species and biodiversity. Rhodiola quadrifida is a rare plant with adaptogenic properties and grows in the highlands in a narrow temperature range of 2-15 degrees C. The aim of our work was to study the growth and content of the main metabolites in two in vitro cultures of Rhodiola quadrifida at temperatures of 5, 15 and 25 degrees C. Hairy roots and calli were cultivated on agar medium for 28 days. The maximum values of the growth index were observed at 25 degrees C (2.32 and 2.12 for calli and hairy roots, respectively). HPLC-MS showed the absence of tyrosol and rosarin in both cultures, and rosin in the root culture. The content of salidroside changed slightly in calli and roots. Cultivation at 5 degrees C significantly stimulated the formation of rosin in calli. Only a residual amount of rosavin was noted in the roots, regardless of temperature. The content of rosin was higher in calli at 15 degrees C with a maximum content at the end of the cultivation cycle 25 mu g/g DW. Thus, Rhodiola quadrifida will be able to grow with an increase in temperature by 10 degrees C but this will be accompanied by a significant reduction in its medicinal value
C1 [Stepanova, Anna Y.; Gladkov, Evgeny A.; Tereshonok, Dmitry V.; Solov'eva, Aleksandra I.] Russian Acad Sci, KA Timiryazev Inst Plant Physiol, Moscow 127276, Russia.
   [Selimov, Renat N.; Goncharova, Elisaveta N.] Bioanalyt Lab OOO NVC Agrovetzaschita, Moscow 129329, Russia.
C3 Russian Academy of Sciences; Timiryazev Institute of Plant Physiology
RP Stepanova, AY; Gladkov, EA (corresponding author), Russian Acad Sci, KA Timiryazev Inst Plant Physiol, Moscow 127276, Russia.
EM step_ann@mail.ru; gladkovu@mail.ru
RI ; Gladkov, Evgeny/JYQ-0933-2024; Tereshonok, Dmitry/G-6706-2014; Anna,
   Stepanova/B-3679-2014
OI Goncharova, Elizaveta/0000-0002-2207-3257; 
FU Ministry of Education and Science of the Russian Federation
   [122042600086-7]
FX This research was funded by the Ministry of Education and Science of the
   Russian Federation (Topic No 122042600086-7).
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U1 2
U2 12
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PY 2023
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AR 28
DI 10.3390/pr11010028
PG 10
WC Engineering, Chemical
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Engineering
GA 8R0ZL
UT WOS:000927627900001
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Tyagi, A
   Sharma, S
   Wu, KR
   Wu, SY
   Xing, F
   Liu, Y
   Zhao, D
   Deshpande, RP
   D'Agostino, RB 
   Watabe, K
AF Tyagi, Abhishek
   Sharma, Sambad
   Wu, Kerui
   Wu, Shih-Ying
   Xing, Fei
   Liu, Yin
   Zhao, Dan
   Deshpande, Ravindra Pramod
   D'Agostino, Ralph B., Jr.
   Watabe, Kounosuke
TI RETRACTED: Nicotine promotes breast cancer metastasis by stimulating N2
   neutrophils and generating pre-metastatic niche in lung (Retracted
   article. See vol. 16, 2025)
SO NATURE COMMUNICATIONS
LA English
DT Article; Retracted Publication
ID EPITHELIAL-MESENCHYMAL TRANSITION; GELATINASE-ASSOCIATED LIPOCALIN;
   OBSTRUCTIVE PULMONARY-DISEASE; TUMOR-ASSOCIATED NEUTROPHILS; LYMPHOCYTE
   RATIO; CIGARETTE-SMOKE; POLYMORPHONUCLEAR LEUKOCYTES; STEM-CELLS;
   IN-VIVO; T-CELLS
AB Smoking has a profound impact on tumor immunity, and nicotine, which is the major addictive component of smoke, is known to promote tumor progression despite being a non-carcinogen. In this study, we demonstrate that chronic exposure of nicotine plays a critical role in the formation of pre-metastatic niche within the lungs by recruiting pro-tumor N2-neutrophils. This pre-metastatic niche promotes the release of STAT3-activated lipocalin 2 (LCN2), a secretory glycoprotein from the N2-neutrophils, and induces mesenchymal-epithelial transition of tumor cells thereby facilitating colonization and metastatic outgrowth. Elevated levels of serum and urine LCN2 is elevated in early-stage breast cancer patients and cancer-free females with smoking history, suggesting that LCN2 serve as a promising prognostic biomarker for predicting increased risk of metastatic disease in female smoker(s). Moreover, natural compound, salidroside effectively abrogates nicotine-induced neutrophil polarization and consequently reduced lung metastasis of hormone receptor-negative breast cancer cells. Our findings suggest a pro-metastatic role of nicotine-induced N2-neutrophils for cancer cell colonization in the lungs and illuminate the therapeutic use of salidroside to enhance the anti-tumor activity of neutrophils in breast cancer patients. Smoking is known to impact tumor immunity and promote tumor progression. Here, the authors show that chronic nicotine exposure promotes the lung pre-metastatic niche formation by recruiting pro-tumor N2-neutrophils that release lipocalin-2.
C1 [Tyagi, Abhishek; Sharma, Sambad; Wu, Kerui; Wu, Shih-Ying; Xing, Fei; Liu, Yin; Zhao, Dan; Deshpande, Ravindra Pramod; Watabe, Kounosuke] Wake Forest Baptist Med Ctr, Dept Canc Biol, Winston Salem, NC 27157 USA.
   [D'Agostino, Ralph B., Jr.] Wake Forest Baptist Med Ctr, Biostat Core, Winston Salem, NC USA.
C3 Wake Forest University; Wake Forest Baptist Medical Center; Wake Forest
   University; Wake Forest Baptist Medical Center
RP Watabe, K (corresponding author), Wake Forest Baptist Med Ctr, Dept Canc Biol, Winston Salem, NC 27157 USA.
EM kwatabe@wakehealth.edu
RI Dagostino Jr, Ralph/C-4060-2017; Zhao, Dan/Y-8065-2019; Deshpande,
   Ravindra/AAE-6392-2021
OI Dagostino Jr, Ralph/0000-0002-3550-8395; Zhao, Dan/0000-0002-5120-6725; 
FU NIH [R01CA173499, R01CA185650, R01CA205067, R37CA230451, T32CA247819];
   Comprehensive Cancer Center of Wake Forest University NCI, National
   Institutes of Health [P30CA012197]; National Cancer Institute
   [R37CA230451, R01CA205067, T32CA247819, P30CA012197] Funding Source: NIH
   RePORTER
FX This work was supported by NIH grants R01CA173499, R01CA185650,
   R01CA205067 (to K.W.), R37CA230451 (to F.X.), and T32CA247819 (to
   S.Y.W.). This study used various Shared Resources including Tumor Tissue
   and Pathology, Cancer Genomics, Flow Cytometry, Cell Engineering and
   Biostatistics that are supported by the Comprehensive Cancer Center of
   Wake Forest University NCI, National Institutes of Health Grant
   (P30CA012197).
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NR 147
TC 217
Z9 241
U1 1
U2 94
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
EI 2041-1723
J9 NAT COMMUN
JI Nat. Commun.
PD JAN 20
PY 2021
VL 12
IS 1
AR 474
DI 10.1038/s41467-020-20733-9
PG 18
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA QA6PW
UT WOS:000613566500009
PM 33473115
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Palumbo, DR
   Occhiuto, F
   Spadaro, F
   Circosta, C
AF Palumbo, Dora Rita
   Occhiuto, Francesco
   Spadaro, Federica
   Circosta, Clara
TI Rhodiola rosea Extract Protects Human Cortical Neurons against Glutamate
   and Hydrogen Peroxide-induced Cell Death Through Reduction in the
   Accumulation of Intracellular Calcium
SO PHYTOTHERAPY RESEARCH
LA English
DT Article
DE Rhodiola rosea L; (Crassulaceae); human cortical neuron; oxidative
   stress; intracellular calcium; neurodegeneration; neuroprotection
ID OXIDATIVE STRESS; PC12 CELLS; HIPPOCAMPAL-NEURONS; ALZHEIMERS-DISEASE;
   CA2+ HOMEOSTASIS; APOPTOSIS; VIABILITY; NEUROTOXICITY; ISOFLAVONES;
   SALIDROSIDE
AB The aim of this study was to investigate the neuroprotective effects of a titolated extract from Rhodiola rosea L. (RrE) and of salidroside (Sa), one of the major biologically active compounds extracted from this medicinal plant, against oxidative stressor hydrogen peroxide (H2O2) and glutamate (GLU)-induced cell apoptosis in a human cortical cell line (HCN 1-A) maintained in culture. The results obtained indicate that exposure of differentiated HCN 1-A neurons to GLU or H2O2 resulted in concentration-dependent cell death. A 24?h pre-treatment with RrE significantly increased cell survival and significantly prevented the plasma membrane damage and the morphological disruption caused by GLU or H2O2, indicating that neurons treated with RrE were protected from the neurotoxicity induced by the oxidative stressor used. In addition, RrE significantly reduced H2O2 or GLU-induced elevation of intracellular free Ca2+ concentration. The results obtained have also shown that Sa caused similar effects in all experimental models used; however, the potency of the action was lower than that of the extract containing corresponding quantities of Sa. These findings indicate that RrE has a neuroprotective effect in cortical neurons and suggest that the antioxidant activity of the RrE, due to the structural features of the synergic active principles they contain, may be responsible for its ability to stabilize cellular Ca2+ homeostasis. Copyright (c) 2011 John Wiley & Sons, Ltd.
C1 [Palumbo, Dora Rita; Occhiuto, Francesco; Spadaro, Federica; Circosta, Clara] Univ Messina, Sch Pharm, Pharmacobiol Dept, I-98168 Messina, Italy.
C3 University of Messina
RP Occhiuto, F (corresponding author), Univ Messina, Sch Pharm, Pharmacobiol Dept, I-98168 Messina, Italy.
EM occhiuto@pharma.unime.it
RI ; /L-3762-2019
OI CIRCOSTA, Clara/0000-0003-0670-3279; 
CR [Anonymous], HERBAL MED PRODUCTS
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NR 34
TC 33
Z9 40
U1 0
U2 26
PU WILEY
PI HOBOKEN
PA 111 RIVER ST, HOBOKEN 07030-5774, NJ USA
SN 0951-418X
EI 1099-1573
J9 PHYTOTHER RES
JI Phytother. Res.
PD JUN
PY 2012
VL 26
IS 6
BP 878
EP 883
DI 10.1002/ptr.3662
PG 6
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 952TZ
UT WOS:000304816700013
PM 22086763
DA 2026-05-27
ER

PT J
AU Liu, J
   Ma, W
   Zang, CH
   Wang, GD
   Zhang, SJ
   Wu, HJ
   Zhu, KW
   Xiang, XL
   Li, CY
   Liu, KP
   Guo, JH
   Li, LY
AF Liu, Jie
   Ma, Wei
   Zang, Cheng-Hao
   Wang, Guo-Dong
   Zhang, Si-Jia
   Wu, Hong-Jie
   Zhu, Ke-Wei
   Xiang, Xiang-Lin
   Li, Chun-Yan
   Liu, Kuang-Pin
   Guo, Jian-Hui
   Li, Li-Yan
TI Salidroside inhibits NLRP3 inflammasome activation and apoptosis in
   microglia induced by cerebral ischemia/reperfusion injury by inhibiting
   the TLR4/NF-ΚB signaling pathway
SO ANNALS OF TRANSLATIONAL MEDICINE
LA English
DT Article
DE Salidroside (Sal); microglia; cerebral ischemia; reperfusion injury;
   NLRP3 inflammasome; apoptosis
ID STERILE INFLAMMATION; ISCHEMIC-STROKE; RECEPTOR 4; DEPRIVATION;
   REPERFUSION; PROTECTS; GLUCOSE; STRESS; OXYGEN; BRAIN
AB Background: The NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome is an important mediator of neuroinflammatory responses that regulates inflammatory injury following cerebral ischemia and may be a potential target. Salidroside (Sal) has good anti-inflammatory effects; however, it remains unclear whether Sal can regulate NLRP3 inflammasome activation through the Toll-like receptor 4 (TLR4)/ nuclear factor kappa B (NF-icB) signaling pathway after cerebral ischemia to alleviate inflammatory injury. Methods: We established an oxygen-glucose deprivation and reoxygenation (OGD/R) model of BV2 cells and a middle cerebral artery occlusion/reperfusion (MCAO/R) rat model. Cell Counting Kit-8 (CCK-8), flow cytometry and terminal deoxynucleotidyl transferase dUTP nick-end labeling (TUNEL) assay were used to detect the viability and apoptosis of BV2 cells. Enzyme-linked immunosorbent assay (ELISA) was used to detect the level of inflammatory factors. 2,3,5-triphenyltetrazolium chloride (TTC) staining and modified Neurological Severity Scale Score (mNSS) were used to detect cerebral infarction volume and neurological deficit in rats. Western blot, immunohistochemistry and immunofluorescence staining were used to detect the protein expression levels. Results: Our results showed that Sal increased viability, inhibited lactate dehydrogenase (LDH) release, and reduced apoptosis in OGD/R-induced BV2 cells. Sal reduced the levels of tumor necrosis factor-a (TNF-a), interleukin (IL)-6, and IL-8. Following induction by OGD/R, BV2 cells exhibited NLRP3 inflammasome activation and increased protein levels of NLRP3, apoptosis-associated speck-like protein containing a CARD (ASC), caspase-1, IL-113, and IL-18. Protein levels of key TLR4 signaling pathway elements, such as TLR4, myeloid differentiation primary response 88 (MyD88), and phosphorylated nuclear factor kappa B p65 (p-NF-icB p65)/NF-icB p65 were upregulated. Interestingly, it was revealed that Sal could reverse these changes. In addition, TAK242, a specific inhibitor of TLR4, had the same effect as Sal treatment on BV2 cells following induction by OGD/R. In the MCAO/R rat model, Sal was also observed to inhibit NLRP3 inflammasome activation in microglia, reduce cerebral infarction volume, and inhibit apoptosis. Conclusions: In summary, we found that Sal inhibited NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-icB signaling pathway, thus playing a protective role. Therefore, Sal may be a promising drug for the clinical treatment of ischemic stroke.
C1 [Liu, Jie; Ma, Wei; Wang, Guo-Dong; Zhang, Si-Jia; Wu, Hong-Jie; Zhu, Ke-Wei; Xiang, Xiang-Lin; Li, Chun-Yan; Liu, Kuang-Pin; Li, Li-Yan] Kunming Med Univ, Inst Neurosci, Kunming, Yunnan, Peoples R China.
   [Zang, Cheng-Hao; Guo, Jian-Hui] First Peoples Hosp Yunnan Prov, Dept Gen Surg 2, 157 Jinbi Rd, Kunming 650032, Yunnan, Peoples R China.
C3 Kunming Medical University; Kunming University of Science & Technology
RP Li, LY (corresponding author), Kunming Med Univ, Inst Neurosci, Kunming, Yunnan, Peoples R China.; Guo, JH (corresponding author), First Peoples Hosp Yunnan Prov, Dept Gen Surg 2, 157 Jinbi Rd, Kunming 650032, Yunnan, Peoples R China.
EM guojianhuikm@163.com; kmliyanl@163.com
RI Wu, Hongjie/OOL-1666-2025; zhang, sijia/NBX-3151-2025
OI Li, Liyan/0009-0002-9275-0265
FU research innovation team of Yunnan province [2019HC022]; National
   Natural Science Foundation of China [31560295, 82160263]
FX This work was supported by the research innovation team of Yunnan
   province (2019HC022 to LYL) and the National Natural Science Foundation
   of China (31560295, 82160263 to LYL).
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   Zhou KC, 2019, J PHARMACOL SCI, V139, P15, DOI 10.1016/j.jphs.2018.10.012
NR 57
TC 47
Z9 56
U1 0
U2 26
PU AME PUBLISHING COMPANY
PI SHATIN
PA FLAT-RM C 16F, KINGS WING PLAZA 1, NO 3 KWAN ST, SHATIN, HONG KONG
   00000, PEOPLES R CHINA
SN 2305-5839
EI 2305-5847
J9 ANN TRANSL MED
JI ANN. TRANSL. MED.
PD NOV
PY 2021
VL 9
IS 22
AR 1694
DI 10.21037/atm-21-5752
PG 16
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA XM9DI
UT WOS:000729117700004
PM 34988203
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xu, B
   Chen, JM
   Gao, YH
   Fan, NQ
   Zhang, SH
AF Xu, Bo
   Chen, Jianmin
   Gao, Yunhua
   Fan, Nengquan
   Zhang, Suohui
TI Design and evaluation of complex plant extract-loaded dissolving
   microneedle for improving periocular wrinkles
SO JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
LA English
DT Article
DE Dissolving microneedle; Plant extract; Periocular wrinkles;
   Anti-wrinkle; Safety assessment; Efficacy evaluation
ID TRANSDERMAL DELIVERY; SKIN; EFFICACY; PATCH; MECHANISMS
AB Periocular wrinkles are among the most prominent signs of facial skin aging, significantly impacting patients' self-confidence and quality of life. Current cosmetic products, such as eye masks and wrinkle-reducing creams, face limitations including nonspecific active ingredient delivery and poor percutaneous absorption, resulting in suboptimal therapeutic results. This study introduces a novel complex plant extract-loaded dissolving microneedle (CPE-DMN), incorporating three active components: panax notoginseng saponins (PNS), rhodioloside, and madecassoside, with strong antioxidant activity to anti-wrinkle function. The CPE-DMN demonstrates sufficient mechanical strength for skin penetration and complete dissolution within 10 min, enabling efficient delivery of active ingredients. In vitro assessments confirmed the system's biosafety and its ability to significantly upregulate the gene expression of col1a1a, col1a1b, and col1a2 in zebrafish, which related to the regeneration of type I collagen. Furthermore, a 56-day clinical trial involving 31 volunteers demonstrated the CPE-DMN's efficacy, showing reduction in wrinkle count and under-eye puffiness, along with improved skin elasticity and firmness. These findings collectively indicate that the CPE-DMN system represents a safe and effective clinical approach for addressing periocular wrinkles.
C1 [Xu, Bo; Gao, Yunhua; Zhang, Suohui] Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, Tech Inst Phys & Chem, Beijing 100190, Peoples R China.
   [Xu, Bo; Gao, Yunhua; Zhang, Suohui] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
   [Chen, Jianmin] Putian Univ, Sch Pharm & Med technol, Putian 351100, Peoples R China.
   [Gao, Yunhua] Beijing CAS Microneedle Technol Ltd, Beijing 102609, Peoples R China.
   [Fan, Nengquan] Chongqing Inst Food & Drug Control, Chongqing 401121, Peoples R China.
C3 Chinese Academy of Sciences; Technical Institute of Physics & Chemistry,
   CAS; Chinese Academy of Sciences; University of Chinese Academy of
   Sciences, CAS; Putian University
RP Zhang, SH (corresponding author), Chinese Acad Sci, Key Lab Photochem Convers & Optoelect Mat, Tech Inst Phys & Chem, Beijing 100190, Peoples R China.
EM suohuizhang@mail.ipc.ac.cn
FU Chongqing Municipal Science and Technology Bureau Scientific Research
   Institution Performance Incentive Guidance Special Project
   [2023JXJLYFX0068]
FX We thank the financial support of the Chongqing Municipal Science and
   Technology Bureau Scientific Research Institution Performance Incentive
   Guidance Special Project (grant number: 2023JXJLYFX0068). We thank the
   Antimicrobial Testing center of the Technical Institute of Physics and
   Chemistry, CAS for the supporting the necessary conditions of the animal
   experiments.
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NR 45
TC 0
Z9 0
U1 8
U2 13
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1773-2247
EI 2588-8943
J9 J DRUG DELIV SCI TEC
JI J. Drug Deliv. Sci. Technol.
PD NOV
PY 2025
VL 113
AR 107355
DI 10.1016/j.jddst.2025.107355
EA AUG 2025
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA 6RC9U
UT WOS:001560026100001
DA 2026-05-27
ER

PT J
AU Wu, DM
   Han, XR
   Wen, X
   Wang, S
   Fan, SH
   Zhuang, J
   Wang, YJ
   Zhang, ZF
   Li, MQ
   Hu, B
   Shan, Q
   Sun, CH
   Lu, J
   Zheng, YL
AF Wu, Dong-Mei
   Han, Xin-Rui
   Wen, Xin
   Wang, Shan
   Fan, Shan-Hua
   Zhuang, Juan
   Wang, Yong-Jian
   Zhang, Zi-Feng
   Li, Meng-Qiu
   Hu, Bin
   Shan, Qun
   Sun, Chun-Hui
   Lu, Jun
   Zheng, Yuan-Lin
TI RETRACTED: Salidroside Protection Against Oxidative Stress Injury
   Through the Wnt/β-Catenin Signaling Pathway in Rats with Parkinson's
   Disease (Retracted article. See vol. 55, pg. 670, 2021)
SO CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
LA English
DT Article; Retracted Publication
DE Salidroside; Parkinson's disease; Wnt/beta-catenin signaling pathway;
   Oxidative stress; 6-OHDA; Apoptosis
ID TAU HYPERPHOSPHORYLATION; MODEL; APOPTOSIS; PHOSPHORYLATION; NEURONS;
   CANCER
AB Background/Aims: Parkinson's disease (PD) is the second most common neurodegenerative disease after Alzheimer's disease, and recent studies suggested that oxidative stress (OS) contributes to the cascade that leads to dopamine cell degeneration in PD. In this study, we hypothesized that salidroside (SDS) offers protection against OS injury in 6-hydroxydopamine (6-OHDA) unilaterally lesioned rats as well as the underlying mechanism. Methods:SDS and LiCI (activators of the Wnt/beta-catenin signaling pathway) administration alone and in combination with 6-OHDA injection in rats was performed 3 days before modeling for 17 consecutive days to verify the regulatory mechanism by which SDS affects the Wnt/beta-catenin signaling pathway as well as to evaluate the protective effect of SDS on PD in relation to OS in vivo. In addition, pheochromocytoma 12 (PC12) cells were incubated with 10 mu mol/L SOS or LiCI alone or with both in combination for 1 h followed by a 24-h incubation with 100 mu mol/L 6-OHDA to obtain in vitro data. Results: In vivo the administration of LiCI was found to ameliorate behavioral deficits and dopaminergic neuron loss; increase superoxide dismutase (SOA) activity, glutathione peroxidase (GSH-Px) levels, and glycogen synthase kinase 3 beta phosphorylation (GSK-3 beta-Ser9); reduce malondialdehyde (MDA) accumulation in the striatum and the GSK-3 beta mRNA level; as well as elevate p-catenin and cyclinD1 mRNA and protein levels in 6-OHDA-injected rats. This SDS treatment regimen was found to strengthen the beneficial effect of LiCI on 6-OHDA-injected rats. In vitro LiCI treatment decreased the toxicity of 6-OHDA on PC12 cells and prevented apoptosis. Additionally, LiCI treatment increased SOA activity, GSH-Px levels, and GSK-38-Ser9 phosphorylation; decreased MDA accumulation in the striatum and GS K-3 beta mRNA levels; as well as increased beta-catenin and cyclinD1 mRNA and protein levels in 6-OHDA-treated PC12 cells. Additionally, SDS treatment increased the protective effect of LiCI on 6-OHDA-treated PC12 cells. Conclusion: Evidence from experimental models suggested that SDS may confer neuroprotection against the neurotoxicity of 6-OHDA in response to OS injury and showed that these beneficial effects may be related to regulation of the Wnt/beta catenin signaling pathway. Therefore, SDS might be a potential therapeutic agent for treating PD. (C) 2018 The Author(s) Published by S. Karger AG, Basel
C1 [Wu, Dong-Mei; Han, Xin-Rui; Wen, Xin; Wang, Shan; Fan, Shan-Hua; Zhuang, Juan; Wang, Yong-Jian; Zhang, Zi-Feng; Li, Meng-Qiu; Hu, Bin; Shan, Qun; Sun, Chun-Hui; Lu, Jun; Zheng, Yuan-Lin] Jiangsu Normal Univ, Sch Life Sci, Key Lab Biotechnol Med Plants Jiangsu Prov, 101 Shanghai Rd, Xuzhou, Jiangsu, Peoples R China.
   [Wu, Dong-Mei; Han, Xin-Rui; Wen, Xin; Wang, Shan; Fan, Shan-Hua; Wang, Yong-Jian; Zhang, Zi-Feng; Li, Meng-Qiu; Hu, Bin; Shan, Qun; Sun, Chun-Hui; Lu, Jun; Zheng, Yuan-Lin] Jiangsu Normal Univ, Coll Hlth Sci, 101 Shanghai Rd, Xuzhou, Jiangsu, Peoples R China.
   [Zhuang, Juan] China Univ Min & Technol, Sch Environm Sci & Spatial Informat, Xuzhou, Jiangsu, Peoples R China.
   [Zhuang, Juan] Huaiyin Normal Univ, Sch Life Sci, Jiangsu Key Lab Ecoagr Biotechnol Hongze Lake, Huaian, Peoples R China.
C3 Jiangsu Normal University; Jiangsu Normal University; China University
   of Mining & Technology; Huaiyin Normal University
RP Lu, J; Zheng, YL (corresponding author), Jiangsu Normal Univ, Sch Life Sci, Key Lab Biotechnol Med Plants Jiangsu Prov, 101 Shanghai Rd, Xuzhou, Jiangsu, Peoples R China.; Lu, J; Zheng, YL (corresponding author), Jiangsu Normal Univ, Coll Hlth Sci, 101 Shanghai Rd, Xuzhou, Jiangsu, Peoples R China.
EM lu_jun75@163.com; ylzheng@jsnu.edu.cn
RI Lu, Jun/N-6109-2019; han, hanxinrui/OOK-2603-2025; Wu,
   Dongmei/AAS-6647-2020
OI Lu, Jun/0000-0002-2801-5330; 
FU Priority Academic Program Development of Jiangsu Higher Education
   Institutions (PAPD); "333 Project" Award of Jiangsu Province; "Qinglan
   Project" of the Young and Middle-aged Academic Leader of Jiangsu College
   and University; National Natural Science Foundation of China [81571055,
   81400902, 81271225, 31201039, 81171012, 30950031]; Major Fundamental
   Research Program of the Natural Science Foundation of the Jiangsu Higher
   Education Institutions of China [13KJA180001]; Cultivate National
   Science Fund for Distinguished Young Scholars of Jiangsu Normal
   University
FX This work was supported by the Priority Academic Program Development of
   Jiangsu Higher Education Institutions (PAPD); the 2016 "333 Project"
   Award of Jiangsu Province, the 2013 "Qinglan Project" of the Young and
   Middle-aged Academic Leader of Jiangsu College and University, the
   National Natural Science Foundation of China (81571055, 81400902,
   81271225, 31201039, 81171012, and 30950031), the Major Fundamental
   Research Program of the Natural Science Foundation of the Jiangsu Higher
   Education Institutions of China (13KJA180001), and grants from the
   Cultivate National Science Fund for Distinguished Young Scholars of
   Jiangsu Normal University. We would like to give our sincere
   appreciation to the reviewers for their helpful comments on this
   article.
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U2 21
PU Cell Physiol Biochem Press GmbH & Co
PI Dsseldorf
PA Herzogstr. 85, Dsseldorf, GERMANY
SN 1015-8987
EI 1421-9778
J9 CELL PHYSIOL BIOCHEM
JI Cell. Physiol. Biochem.
PY 2018
VL 46
IS 5
BP 1793
EP 1806
DI 10.1159/000489365
PG 14
WC Cell Biology; Physiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology; Physiology
GA GH1HG
UT WOS:000433153200004
PM 29705802
OA gold
DA 2026-05-27
ER

PT J
AU Kim, H
   Kong, CS
   Seo, Y
AF Kim, Hojun
   Kong, Chang-Suk
   Seo, Youngwan
TI Salidroside, 8(E)-Nuezhenide, and Ligustroside from Ligustrum
   japonicum Fructus Inhibit Expressions of MMP-2 and-9 in HT 1080
   Fibrosarcoma
SO INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
LA English
DT Article
DE Ligustrum japonicum fructus; matrix metalloproteinases; MAPK; HT1080
ID MATRIX METALLOPROTEINASES; CANCER CELLS; INVASION; MAPK; CONSTITUENTS;
   PROGRESSION; MIGRATION; MOTILITY; GROWTH; ROLES
AB A phenyl ethanoid, salidroside (SAL), and two secoiridoids, 8(E)-nuezhenide (NZD) and ligustroside (LIG), were isolated from fruits of Ligustrum japonicum, used as traditional folk medicine, and their chemical structures were elucidated by the comparison of spectral data with published literature. Matrix metalloproteinases (MMPs) are major enzymes that play crucial roles in the metastasis and invasive behavior of tumors. In particular, MMP-2 and MMP-9, regulated by the MAPK signaling pathways, including p38, ERK and JNK, are known to play a key role in the degradation of the basement membrane. In the present study, the effects of SAL, NZD and LIG on the expression of MMP-2 and -9 were examined in phorbol 12-myristate 13-acetate (PMA)-induced HT 1080 cells. All the compounds significantly lowered the amount of MMP-2 and MMP-9 released, as determined by gelatin zymography and ELISA. In addition, the mRNA and protein expression levels of MMP-2 and MMP-9 were significantly suppressed, as measured by RT-PCR and Western blotting. According to the Western blotting assay, SAL and LIG effectively reduced the expression of MMP-2 in a dose-dependent manner. NZD lowered the expression of MMP-9 in a similar way. The phosphorylation of p38, ERK and JNK was also significantly suppressed by these compounds. These findings suggest that all the compounds regulate the release and expression of MMP-2 and MMP-9 via MAPK signaling pathways.
C1 [Kim, Hojun; Seo, Youngwan] Korea Maritime & Ocean Univ, Div Convergence Marine Sci, Pusan 49112, South Korea.
   [Kong, Chang-Suk] Silla Univ, Dept Food & Nutr, Pusan 46958, South Korea.
C3 Korea Maritime & Ocean University; Silla University
RP Seo, Y (corresponding author), Korea Maritime & Ocean Univ, Div Convergence Marine Sci, Pusan 49112, South Korea.
EM cskong@silla.ac.kr; cskong@silla.ac.kr; cskong@silla.ac.kr
FU Basic Science Research Program through the National Research Foundation
   of Korea (NRF) - Ministry of Science and ICT [2019R1F1A1059325]
FX This work was financially supported by Basic Science Research Program
   through the National Research Foundation of Korea (NRF) funded by the
   Ministry of Science and ICT (No. 2019R1F1A1059325).
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NR 35
TC 9
Z9 11
U1 1
U2 18
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 1661-6596
EI 1422-0067
J9 INT J MOL SCI
JI Int. J. Mol. Sci.
PD MAR
PY 2022
VL 23
IS 5
AR 2660
DI 10.3390/ijms23052660
PG 11
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA ZW9JB
UT WOS:000771519500001
PM 35269801
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zhang, Y
   Yu, SY
   Guo, XY
   Wang, LY
   Yu, L
   Wang, P
AF Zhang, Yan
   Yu, Shuyuan
   Guo, Xinyi
   Wang, Luoying
   Yu, Ling
   Wang, Ping
TI Therapeutic potential of salidroside in preserving rat cochlea organ of
   corti from gentamicin-induced injury through modulation of NRF2
   signaling and GSK3β/NF-κB pathway
SO PLOS ONE
LA English
DT Article
ID OXIDATIVE STRESS; MODEL; INFLAMMATION; OTOTOXICITY; APOPTOSIS; PROTECTS;
   DEFICITS; DAMAGE; CELLS
AB Salidroside (SAL) is a phenol glycoside compound found in plants of the Rhodiola genus which has natural antioxidant and free radical scavenging properties. SAL are able to protect against manganese-induced ototoxicity. However, the molecular mechanism by which SAL reduces levels of reactive oxygen species (ROS) is unclear. Here, we established an in vitro gentamicin (GM) ototoxicity model to observe the protective effect of SAL on GM-induced hair cells (HC) damage. Cochlear explants of postnatal day 4 rats were obtained and randomly divided into six groups: two model groups (treatment with 0.2 mM or 0.4 mM GM for 24 h); two 400 mu mol/L SAL-pretreated groups pretreatment with SAL for 3 h followed by GM treatment (0.2 mM or 0.4 mM) for 24 h; 400 mu mol/L SAL group (treatment with SAL for 24 h); control group (normal cultured cochlear explants). The protective effects of SAL on GM-induced HC damage, and on mRNA and protein levels of antioxidant enzymes were observed. HC loss occurred after 24 h of GM treatment. Pretreatment with SAL significantly reduced GM-induced OHC loss. In cochlear tissues, mRNA and protein levels of NRF2 and HO-1 were enhanced in the GM alone group compared with the SAL pretreatment GM treatment group. SAL may protect against GM-induced ototoxicity by regulating the antioxidant defense system of cochlear tissues; SAL can activate NRF2/HO-1 signaling, inhibit NF-kappa B activation, activate AKT, and increase inhibitory phosphorylation of GSK3 beta to decrease GSK3 activity, all of which exert antioxidant effects.
C1 [Zhang, Yan; Yu, Shuyuan; Guo, Xinyi; Wang, Ping] First Hosp Jilin Univ, Dept Otolaryngol Head & Neck Surg, Changchun, Jilin, Peoples R China.
   [Wang, Luoying] Jilin Univ, Coll Pharm, Dept Regenerat Med, Changchun, Jilin, Peoples R China.
   [Yu, Ling] Second Hosp Jilin Univ, Dept Pharm, Changchun, Jilin, Peoples R China.
C3 Jilin University; Jilin University; Jilin University
RP Wang, P (corresponding author), First Hosp Jilin Univ, Dept Otolaryngol Head & Neck Surg, Changchun, Jilin, Peoples R China.; Yu, L (corresponding author), Second Hosp Jilin Univ, Dept Pharm, Changchun, Jilin, Peoples R China.
EM wang_ping@jlu.edu.cn; yulingyxb@jlu.edu.cn
RI Yu, Shuyuan/LTD-8611-2024; Wang, Ping/GZB-2001-2022
FU Jilin Provincial Science& Technology Development [20200201493JC,
   20200404183YY]
FX This work was supported by grants from Jilin Provincial Science&
   Technology Development (Grant No. 20200201493JC and 20200404183YY,).
   Initials of the authors who received each award: PW Grant No.
   20200201493JC YZ Grant No. 20200404183YY The founder of the research,
   Ping Wang is in charge of Supervision and Yan Zhang is writing-Original
   Drafting in this research.
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NR 38
TC 1
Z9 3
U1 0
U2 16
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 14
PY 2024
VL 19
IS 3
AR e0298529
DI 10.1371/journal.pone.0298529
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA MG0U3
UT WOS:001192363700063
PM 38483863
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Fuji, Y
   Uchida, K
   Akashi, T
   Ohtsuki, T
   Matsufuji, H
   Hirai, MY
AF Fuji, Yushiro
   Uchida, Kai
   Akashi, Tomoyoshi
   Ohtsuki, Takashi
   Matsufuji, Hiroshi
   Hirai, Masami Yokota
TI Molecular Identification of UDP-Sugar-Dependent Glycosyltransferase and
   Acyltransferase Involved in the Phenylethanoid Glycoside Biosynthesis
   Induced by Methyl Jasmonate in Sesamum indicum L.
SO PLANT AND CELL PHYSIOLOGY
LA English
DT Article
DE Acteoside; Acyltransferase; Biosynthesis; Glucosyltransferase;
   Phenylethanoid glycoside; Sesamum indicum L; UDP-sugar-dependent
   glycosyltransferase
ID SUSPENSION-CULTURES; ACTEOSIDE; GLUCOSYLTRANSFERASE; OVEREXPRESSION;
   IMPROVEMENT; CLONING; GENES
AB Sesame (Sesamum indicum L.) plants contain large amounts of acteoside, a typical phenylethanoid glycoside (PhG) that exhibits various pharmacological activities. Although there is increasing interest in the biosynthesis of PhGs for improved production, the pathway remains to be clarified. In this study, we established sesame-cultured cells and performed transcriptome analysis of methyl jasmonate (MeJA)-treated cultured cells to identify enzyme genes responsible for glucosylation and acylation in acteoside biosynthesis. Among the genes annotated as UDP-sugar-dependent glycosyltransferase (UGT) and acyltransferase (AT), 34 genes and one gene, respectively, were upregulated by MeJA in accordance with acteoside accumulation. Based on a phylogenetic analysis, five UGT genes (SiUGT1-5) and one AT gene (SiAT1) were selected as candidate genes involved in acteoside biosynthesis. Additionally, two AT genes (SiAT2-3) were selected based on sequence identity. Enzyme assays using recombinant SiUGT proteins revealed that SiUGT1, namely, UGT85AF10, had the highest glucosyltransferase activity among the five candidates against hydroxytyrosol to produce hydroxytyrosol 1-O-glucoside. SiUGT1 also exhibited glucosyltransferase activity against tyrosol to produce salidroside (tyrosol 1-O-glucoside). SiUGT2, namely, UGT85AF11, had similar activity against hydroxytyrosol and tyrosol. Enzyme assay using the recombinant SiATs indicated that SiAT1 and SiAT2 had activity transferring the caffeoyl group to hydroxytyrosol 1-O-glucoside and salidroside (tyrosol 1-O-glucoside) but not to decaffeoyl-acteoside. The caffeoyl group was attached mainly at the 4-position of glucose of hydroxytyrosol 1-O-glucoside, followed by attachment at the 6-position and the 3-position of glucose. Based on our results, we propose an acteoside biosynthetic pathway induced by MeJA treatment in sesame.
C1 [Fuji, Yushiro; Uchida, Kai; Hirai, Masami Yokota] RIKEN, Ctr Sustainable Resource Sci, Yokohama 2300045, Japan.
   [Fuji, Yushiro; Ohtsuki, Takashi; Matsufuji, Hiroshi] Nihon Univ, Coll Bioresource Sci, Dept Food Sci & Technol, Fujisawa, Kanagawa 2520880, Japan.
   [Akashi, Tomoyoshi] Nihon Univ, Coll Bioresource Sci, Dept Appl Biol Sci, Fujisawa, Kanagawa 2520880, Japan.
   [Hirai, Masami Yokota] Nagoya Univ, Grad Sch Bioagr Sci, Dept Appl Biosci, Nagoya 4648601, Japan.
C3 RIKEN; Nihon University; Nihon University; Nagoya University
RP Hirai, MY (corresponding author), RIKEN, Ctr Sustainable Resource Sci, Yokohama 2300045, Japan.; Hirai, MY (corresponding author), Nagoya Univ, Grad Sch Bioagr Sci, Dept Appl Biosci, Nagoya 4648601, Japan.
EM masami.hirai@riken.jp
RI Uchida, Kai/C-3598-2017; Hirai, Masami/JAC-8278-2023
OI Fuji, Yushiro/0009-0004-4465-7175; Hirai, Masami/0000-0003-0802-6208
FU Grants-in-Aid for Scientific Research [21K14788] Funding Source: KAKEN;
   Japan Society for the Promotion of Science [JP18K19186 JP21K14788]
   Funding Source: Medline
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NR 52
TC 12
Z9 14
U1 4
U2 45
PU OXFORD UNIV PRESS
PI OXFORD
PA GREAT CLARENDON ST, OXFORD OX2 6DP, ENGLAND
SN 0032-0781
EI 1471-9053
J9 PLANT CELL PHYSIOL
JI Plant Cell Physiol.
PD JUL 17
PY 2023
VL 64
IS 7
BP 716
EP 728
DI 10.1093/pcp/pcad053
EA JUN 2023
PG 13
WC Plant Sciences; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Cell Biology
GA L7WS3
UT WOS:001006891100001
PM 37233612
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhang, LN
   Yin, H
   Xie, YM
   Zhang, YY
   Dong, FH
   Wu, K
   Yang, L
   Lv, HY
AF Zhang, Luna
   Yin, Hang
   Xie, Yumin
   Zhang, Yueyue
   Dong, Feihong
   Wu, Ke
   Yang, Le
   Lv, Huiyi
TI Exploring the anti-oxidative mechanisms of Rhodiola rosea in
   ameliorating myocardial fibrosis through network pharmacology and in
   vitro experiments
SO MOLECULAR MEDICINE REPORTS
LA English
DT Article
DE network pharmacology; Rhodiola rosea; salidroside; oxidative stress;
   myocardial fibrosis
ID ANGIOTENSIN-ALDOSTERONE SYSTEM
AB Myocardial fibrosis (MF) significantly compromises cardiovascular health by affecting cardiac function through excessive collagen deposition. This impairs myocardial contraction and relaxation and leads to severe complications and increased mortality. The present study employed network pharmacology and in vitro assays to investigate the bioactive compounds of Rhodiola rosea and their targets. Using databases such as HERB, the Encyclopedia of Traditional Chinese Medicine, Pubchem, OMIM and GeneCards, the present study identified effective components and MF-related targets. Network analysis was conducted with Cytoscape to develop a Drug-Ingredient-Target-Disease network and the STRING database was utilized to construct a protein-protein interaction network. Key nodes were analyzed for pathway enrichment using Gene Ontology and Kyoto Encyclopedia of Genes and Genomes. Molecular interactions were further explored through molecular docking techniques. The bioactivity of salidroside (SAL), the principal component of Rhodiola rosea, against MF was experimentally validated in H9c2 cardiomyocytes treated with angiotensin II and assessed for cell viability, protein expression and oxidative stress markers. Network pharmacology identified 25 active ingredients and 372 targets in Rhodiola rosea, linking SAL with pathways such as MAPK, EGFR, advanced glycosylation end products-advanced glycosylation end products receptor and Forkhead box O. SAL showed significant interactions with core targets such as albumin, IL6, AKT serine/threonine kinase 1, MMP9 and caspase-3. In vitro, SAL mitigated AngII-induced increases in collagen I and alpha smooth muscle actin protein levels and oxidative stress markers, demonstrating dose-dependent effectiveness in reversing MF. SAL from Rhodiola rosea exhibited potent anti-oxidative properties that mitigated MF by modulating multiple molecular targets and signaling pathways. The present study underscored the therapeutic potential of SAL in treating oxidative stress-related cardiovascular diseases.
C1 [Zhang, Luna; Xie, Yumin; Zhang, Yueyue; Dong, Feihong; Wu, Ke; Yang, Le; Lv, Huiyi] Dalian Med Univ, Dept Pharm, Affiliated Hosp 2, 467 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China.
   [Yin, Hang] Weill Cornell Med, Inst Computat Biomed, New York, NY 10021 USA.
C3 Dalian Medical University; Cornell University; Weill Cornell Medicine
RP Yang, L; Lv, HY (corresponding author), Dalian Med Univ, Dept Pharm, Affiliated Hosp 2, 467 Zhongshan Rd, Dalian 116023, Liaoning, Peoples R China.
EM yl0520@dmu.edu.cn; huiyi-l@dmu.edu.cn
FU National Natural Science Foundation of China
FX Not applicable.
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NR 42
TC 2
Z9 3
U1 0
U2 23
PU SPANDIDOS PUBL LTD
PI ATHENS
PA POB 18179, ATHENS, 116 10, GREECE
SN 1791-2997
EI 1791-3004
J9 MOL MED REP
JI Mol. Med. Rep.
PD DEC
PY 2024
VL 30
IS 6
AR 214
DI 10.3892/mmr.2024.13338
PG 13
WC Oncology; Medicine, Research & Experimental
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Oncology; Research & Experimental Medicine
GA I4K7V
UT WOS:001329969700001
PM 39370810
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Zhang, WJ
   Huai, Y
   Miao, ZP
   Chen, C
   Shahen, M
   Rahman, SU
   Alagawany, M
   Abd El-Hack, ME
   Zhao, HP
   Qian, AR
AF Zhang, Wenjuan
   Huai, Ying
   Miao, Zhiping
   Chen, Chu
   Shahen, Mohamed
   Rahman, Siddiq Ur
   Alagawany, Mahmoud
   Abd El-Hack, Mohamed E.
   Zhao, Heping
   Qian, Airong
TI Systems pharmacology approach to investigate the molecular mechanisms of
   herb Rhodiola rosea L. radix
SO DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY
LA English
DT Article
DE Target fishing; salidroside; traditional Chinese medicine; pathway
   enrichment; GO analysis
ID ISCHEMIA-REPERFUSION INJURY; KAPPA-B PATHWAY; DRUG DISCOVERY;
   ALPHA-PINENE; MULTISCALE MECHANISMS; SALIDROSIDE; RECEPTOR; APOPTOSIS;
   INHIBITION; CANCER
AB Rhodiola rosea L. radix (RRL) is one of the most popular medical herb which has been widely used for the treatment of different diseases effectively, including cardiovascular diseases and nerve system diseases. However, due to the multiple compounds in RRL, the underlying molecular mechanisms of RRL are remained unclear. To decipher the action mechanisms of RRL from a systematic perspective, a systems pharmacology approach integrated absorption, distribution, metabolism, and excretion (ADME) system, drug targeting, and network analysis was introduced. First, by the ADME screening system and the target fishing process, 56 potential active compounds and 62 targets were obtained, respectively. In addition, compound-target network demonstrated that most compounds interacted with multiple targets, indicating that RRL may enhance its therapeutic effects probably through hitting on multiple targets in a holistic level. Moreover, target-pathway network and gene ontology analysis showed that multiple targets of RRL were involved in several biological pathways, i.e. Neuroactive ligand-receptor interaction, calcium signaling pathway, adrenergic signaling in cardiomyocytes, and VEGF signaling pathway, which dissecting the therapeutic effects of RRL on various diseases, such as cardiovascular diseases, depression, adaptation diseases, etc. In summary, this work successfully explains the potential active compounds and the multi-scale curative action mechanisms of RRL for treating various diseases; meanwhile, it implies that RRL could be applied as a novel therapeutic agent in arthritic diseases. Most importantly, this work provides an in silico strategy to understand the action mechanisms of herbal medicines from molecular/system levels, which will promote the new drug development of traditional Chinese medicine.
C1 [Zhang, Wenjuan; Huai, Ying; Miao, Zhiping; Qian, Airong] Northwestern Polytech Univ, NPU UAB Joint Lab Bone Metab, Res Ctr Special Med & Hlth Syst Engn,Sch Life Sci, Lab Bone Metab,Key Lab Space Biosci & Biotechnol, Xian, Shaanxi, Peoples R China.
   [Chen, Chu; Zhao, Heping] Xi An Jiao Tong Univ, Clin Lab, Coll Med, Honghui Hosp, Xian 710054, Shaanxi, Peoples R China.
   [Shahen, Mohamed] Tanta Univ, Zool Dept, Fac Sci, Tanta, Egypt.
   [Rahman, Siddiq Ur] Northwest A&F Univ, Coll Life Sci, Yangling, Shaanxi, Peoples R China.
   [Alagawany, Mahmoud; Abd El-Hack, Mohamed E.] Zagazig Univ, Dept Poultry, Fac Agr, Zagazig 44511, Egypt.
C3 Northwestern Polytechnical University; Xi'an Jiaotong University;
   Egyptian Knowledge Bank (EKB); Tanta University; Northwest A&F
   University - China; Egyptian Knowledge Bank (EKB); Zagazig University
RP Zhao, HP (corresponding author), Xi An Jiao Tong Univ, Clin Lab, Coll Med, Honghui Hosp, Xian 710054, Shaanxi, Peoples R China.; Abd El-Hack, ME (corresponding author), Zagazig Univ, Dept Poultry, Fac Agr, Zagazig 44511, Egypt.; Qian, AR (corresponding author), Northwestern Polytech Univ, Sch Life Sci, Inst Special Environm Biophys, Key Lab Space Biosci & Biotechnol, Xian 710072, Shaanxi, Peoples R China.
EM m.ezzat@zu.edu.eg; redcrossjyk@163.com; qianair@nwpu.edu.cn
RI Alagawany, Mahmoud/P-3051-2014; Abd El-Hack, Mohamed/H-9342-2019;
   shahen, mohamed/AAB-6810-2020; /AAP-1706-2020
OI Abd El-Hack, Mohamed/0000-0002-2831-8534; shahen,
   mohamed/0000-0003-3608-2581; 
FU China's Post-doctoral Science Fund [2017M623249]; Fundamental Research
   Funds for the Central Universities [3102017OQD050]; National Natural
   Science Foundation of China [31570940]; Key Research and Development
   Project of Shaanxi Province [2018SF-363]
FX This work was supported by China's Post-doctoral Science Fund
   [2017M623249], the Fundamental Research Funds for the Central
   Universities [3102017OQD050], the National Natural Science Foundation of
   China [31570940] and The Key Research and Development Project of Shaanxi
   Province [2018SF-363].
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NR 78
TC 14
Z9 16
U1 1
U2 78
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0363-9045
EI 1520-5762
J9 DRUG DEV IND PHARM
JI Drug Dev. Ind. Pharm.
PD MAR 4
PY 2019
VL 45
IS 3
BP 456
EP 464
DI 10.1080/03639045.2018.1546316
PG 9
WC Chemistry, Medicinal; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HM4VY
UT WOS:000459474700012
PM 30449200
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU Zhou, J
   Yan, S
   Guo, X
   Gao, YG
   Chen, SQ
   Li, XH
   Zhang, YH
   Wang, QB
   Zheng, T
   Chen, L
AF Zhou, Jun
   Yan, Shan
   Guo, Xu
   Gao, Yanguo
   Chen, Shiqi
   Li, Xiaohan
   Zhang, Yonghong
   Wang, Qibin
   Zheng, Tao
   Chen, Li
TI Salidroside protects pancreatic ?-cells against pyroptosis by regulating
   the NLRP3/GSDMD pathway in diabetic conditions
SO INTERNATIONAL IMMUNOPHARMACOLOGY
LA English
DT Article
DE Diabetes mellitus; Pancreatic ?-cells; Hyperglycemia; NLRP3
   inflammasome; gasdermin D; Pyroptosis
ID NLRP3 INFLAMMASOME; OXIDATIVE STRESS; ACTIVATION; DISEASE; TXNIP
AB The NACHT, LRP, and PYD domains-containing protein 3 (NLRP3) inflammasome-evoked chronic inflammation is involved in the pathogenesis of diabetes mellitus (DM), and the NLRP3/gasdermin D (GSDMD)-mediated canonical pathway of pyroptosis leads to the loss of pancreatic beta-cells and failure of pancreatic function in DM. A previous study demonstrated that salidroside (SAL) alleviates the pathological hyperplasia of pancreatic beta-cells in db/db mice. However, it is not clear whether the NLRP3/GSDMD pathway-mediated pyroptosis can be regulated by SAL. In addition, the action of SAL on pancreatic beta-cells in DM remains poorly understood. Thus, this study aimed to investigate the effects and underlying mechanisms of SAL on pancreatic beta-cell pyroptosis. Rat insulinoma (INS-1) cells were cultured in a medium containing either high glucose (HG) or HG plus high insulin (HGHI), and the effects of SAL on cell viability, AMP-activated protein kinase (AMPK) activity, reactive oxygen species (ROS) generation, NLRP3/GSDMD activation, and pyroptotic body formation were assessed. Streptozocin-induced DM mice were used to further investigate the effects of SAL on pancreatic pyroptosis. The results revealed aberrances on cell viability, AMPK activity, ROS generation, NLRP3/GSDMD activation, and pyroptotic body formation in HG- and HG-HI-exposed INS-1 cells; these abnormal effects were corrected by SAL in both a concentration- and AMPK-dependent manner. Moreover, SAL administration activated AMPK, suppressed NLRP3/GSDMD signaling, and protected pancreatic beta-cells against pyroptosis in DM mice. These findings suggest that SAL promotes AMPK activation to suppress NLRP3/GSDMD-related pyroptosis in pancreatic beta-cells under DM conditions.
C1 [Zhou, Jun; Yan, Shan; Guo, Xu; Gao, Yanguo; Chen, Shiqi; Li, Xiaohan; Zhang, Yonghong; Wang, Qibin; Zheng, Tao; Chen, Li] Hubei Univ Med, Sch Pharmaceut Sci, Shiyan, Hubei, Peoples R China.
   [Zhou, Jun; Yan, Shan; Guo, Xu; Gao, Yanguo; Chen, Shiqi; Li, Xiaohan; Zhang, Yonghong; Wang, Qibin; Zheng, Tao; Chen, Li] Hubei Univ Med, Taihe Hosp, Inst Wudang Tradit Chinese Med, Shiyan, Hubei, Peoples R China.
   [Wang, Qibin; Zheng, Tao; Chen, Li] Hubei Univ Med, Taihe Hosp, Dept Pharm, Shiyan, Hubei, Peoples R China.
   [Zheng, Tao; Chen, Li] 32 Renming Rd, Shiyan, Hubei, Peoples R China.
C3 Hubei University of Medicine; Hubei University of Medicine; Hubei
   University of Medicine
RP Zheng, T; Chen, L (corresponding author), 32 Renming Rd, Shiyan, Hubei, Peoples R China.
EM ztice@foxmail.com; chenli0201@sina.com
RI Zheng, Tao/JOZ-1467-2023
OI Zheng, Tao/0000-0003-1742-1357
FU National Natural Science Foundation of China [81703582]; Hubei
   Provincial Natural Science Foundation of China [2016CFB153, 2020CFB713];
   Health Commission of Hubei Province Scientific Research Project
   [WJ2019M057, WJ2021ZH0017]; Advantages Discipline Group (Biology and
   Medicine) Project in Higher Education of Hubei Province [2021-2025,
   2022BMXKQT3]; Innovative Research Program for Graduate of Hubei
   University of Medicine [YC2021022, YC2021025, YC2022056]
FX Funding This work was supported by grants from the National Natural
   Science Foundation of China (81703582) , the Hubei Provincial Natural
   Science Foundation of China (2016CFB153 and 2020CFB713) , the Health
   Commission of Hubei Province Scientific Research Project (WJ2019M057 and
   WJ2021ZH0017) , the Advantages Discipline Group (Biology and Medicine)
   Project in Higher Education of Hubei Province (2021-2025) (2022BMXKQT3)
   , and the Innovative Research Program for Graduate of Hubei University
   of Medicine (YC2021022, YC2021025, and YC2022056) .
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PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1567-5769
EI 1878-1705
J9 INT IMMUNOPHARMACOL
JI Int. Immunopharmacol.
PD JAN
PY 2023
VL 114
AR 109543
DI 10.1016/j.intimp.2022.109543
EA DEC 2022
PG 12
WC Immunology; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Immunology; Pharmacology & Pharmacy
GA E7LX2
UT WOS:000977326900001
PM 36508922
DA 2026-05-27
ER

PT J
AU Chen, C
   Chen, HT
   Dingda, D
   Wang, L
   Gao, FB
AF Chen, Chen
   Chen, Haotian
   Dingda, Duojie
   Wang, Lei
   Gao, Fabao
TI The primary studies of epigallocatechin-3-gallate in improving brain
   injury induced by chronic high-altitude natural environment in rats by
   7.0T high-field MR imaging
SO ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
LA English
DT Article
DE High altitude; Hypoxia; Drug intervention; QSM
ID (-)-EPIGALLOCATECHIN GALLATE; MEMORY IMPAIRMENT; OXIDATIVE STRESS;
   HYPOXIA; MECHANISMS; SALIDROSIDE; APOPTOSIS; DEFICITS; MITOCHONDRIAL;
   POLYPHENOL
AB Background: Epigallocatechin-3-gallate (EGCG) is one of the most abundant and important bioactive poly- phenolic compounds in green tea. However, despite its potent antioxidant effects, its neuroprotective effects on chronic high altitude (HA)-induced nerve damage have not been reported. The purpose of this study is to use quantitative susceptibility mapping (QSM) with pathology to dynamically evaluate the status of brain damage and the effect of EGCG. Methods: A model of HA environments-induced brain injury was established of Sprague-Dawley (SD) rats in a natural plateau environment for 4 weeks, 8 weeks, 12 weeks and 20 weeks. Behavioral alterations were then observed and assessed with the open field test (OFT) and Morris water maze (MWM) test. The microglial activation, nissl staining and neural degeneration by Fluoro Jade B in the hippocampus of the rats were observed by immunohistochemistry. In the rats, serum erythropoietin (EPO), hippocampal inflammatory cytokines (interleukin-1 beta [IL-1 beta], interleukin-6 [IL-6] and tumor necrosis factor-alpha [TNF-alpha]), ferritin, oxidative stress (superoxide dismutase [SOD], glutathione peroxidase [GSH-Px], catalase [CAT] and malondialdehyde [MDA]) were detected using ELISA kits and biochemical methods. Iron accumulation was observed by QSM and colorimetry. Iron metabolisms (ceruloplasmin [Cp], transferrin [Tf], divalent metal transport1 [DMT1] and hepcidin [Hep]) were detected using qPCR. Neural ultrastructural changes were evaluated with electron microscope. Salidroside treatment was chosen as the positive control group in ELISA, biochemical detection and electron microscopy. Results: The susceptibility values in the left and right hippocampus, the hippocampal ferritin, serum and hippocampal iron content increased significantly after HA exposure. The expression of hippocampal Cp and Hep decreased and the expression of Tf increased. Nissl staining revealed that the neurons of hippocampal CA1 region of h-20w group were small and irregular, atrophied, and nuclear shrinkage. Tissue oxidative stress and inflammatory indicators (MDA, TNF-alpha, IL-1 beta, IL-6) increased while antioxidant enzymes (SOD, CAT, GSH-Px) decreased. EGCG attenuated HA environments-induced cognitive impairment, iron accumulation, microglial activation and neural degeneration. The effects of EGCG in reducing EPO and the metal chelating property with respect to iron were dose-dependent, with effects of EGCG (50 mg/kg) being similar to those of salidroside (50 mg/kg). Conclusions: EGCG can act as a neuroprotective agent against chronic HA environments-mediated neural injuries. QSM provides a potential complementary imaging technique to detect the effect of treating HA diseases.
C1 [Chen, Chen] Henan Prov Peoples Hosp, Dept Radiol, Zhengzhou, Henan, Peoples R China.
   Zhengzhou Univ, Peoples Hosp, Zhengzhou, Henan, Peoples R China.
   [Chen, Chen; Chen, Haotian; Gao, Fabao] Sichuan Univ, West China Hosp, Dept Radiol, 37 Guoxue Rd, Chengdu, Peoples R China.
   [Chen, Haotian] Univ Elect Sci & Technol China, Sichuan Prov Peoples Hosp, Dept Radiol, Chengdu, Sichuan, Peoples R China.
   [Dingda, Duojie] Yushu Peoples Hosp, Dept Radiol, Yushu, Qinghai, Peoples R China.
   [Wang, Lei; Gao, Fabao] Sichuan Univ, West China Hosp, Mol Imaging Lab, Chengdu, Sichuan, Peoples R China.
C3 Zhengzhou University; Zhengzhou University; Sichuan University;
   University of Electronic Science & Technology of China; Sichuan
   Provincial People's Hospital; Sichuan University
RP Gao, FB (corresponding author), Sichuan Univ, West China Hosp, Dept Radiol, 37 Guoxue Rd, Chengdu, Peoples R China.
EM gaofabao@wchscu.cn
FU National Natural Science Founda-tion of China [81930046]; Key Research
   and Development Program of the Department of Science and Technology of
   the Tibet Autonomous Region [XZ202402ZY0003]
FX Funding This study was supported by the National Natural Science
   Founda-tion of China (NO. 81930046) and the Key Research and Development
   Program of the Department of Science and Technology of the Tibet
   Autonomous Region (XZ202402ZY0003) .
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NR 43
TC 4
Z9 4
U1 2
U2 12
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0003-9861
EI 1096-0384
J9 ARCH BIOCHEM BIOPHYS
JI Arch. Biochem. Biophys.
PD FEB
PY 2025
VL 764
AR 110224
DI 10.1016/j.abb.2024.110224
EA DEC 2024
PG 8
WC Biochemistry & Molecular Biology; Biophysics
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Biophysics
GA O8A0V
UT WOS:001373277300001
PM 39586562
OA hybrid
DA 2026-05-27
ER

PT J
AU Wang, HJ
   Yousaf, W
   Haseeb, A
   Wang, ZY
   Zheng, JG
AF Wang, Hejie
   Yousaf, Wafa
   Haseeb, Abdul
   Wang, Ziyang
   Zheng, Jiangang
TI Salidroside ameliorates diabetic amyotrophy by targeting Caspase-3 to
   inhibit apoptosis
SO SCIENTIFIC REPORTS
LA English
DT Article
DE Salidroside; Diabetic amyotrophy; Network pharmacology; Computational
   biology; Apoptosis; Caspase-3
AB In this study, the Streptozotocin (STZ)-induced diabetes model in rats was employed to assess and verify the activity of salidroside (SAL) in ameliorating diabetic amyotrophy (DA). Network pharmacology analysis was used to obtain SDS-related targets, DA-related targets, and their intersectional targets. After subjecting the targets to GO enrichment and KEGG pathway analysis, a network "target pathway for SAL in ameliorating DA" was set up. Next, the Schrodinger Maestro 13.5 software was utilized for molecular docking to ascertain the binding free energy and binding mode between SAL and target proteins. Molecular dynamics simulations were performed using the Desmond program. Saturation mutation analysis was performed using Schrodinger's Maestro 13.5 software. SPR technology was used to explore the affinity between SAL and Caspase-3 protein. The expression level of Cleaved-Caspase-8, Caspase-8 p18, Cleaved-Caspase-3, Caspase-3 p17, PARP, and PARP P85 proteins in gastrocnemius tissue were determined by Western blotting (WB) analysis. In an STZ-induced rat diabetic model, SAL treatment significantly (P < 0.05) reduced blood glucose levels and increased forepaw force. HE and Masson staining results indicated that SAL treatment could significantly increase the mean muscle fiber area (P < 0.01) and decrease fibrosis (P < 0.05). Immunohistochemical results revealed that SAL treatment significantly increased (P < 0.01) the expression of Myogenin and decreased (P < 0.001) the expression of FBXO32 in gastrocnemius muscle tissue. Network pharmacological analysis identified that there were a total of 61 intersection proteins, among which TNF, APP, Caspase-3, PPARG, NQO1, HDAC1, BCL2, SRC, HDAC6, ACE, MAPK3, HSP90AA1, ATM, and REN emerged as potential core targets for SAL to ameliorate DA. Based on the crystal structure of the potential core protein, the complex structure model of the core target-SAL was created using molecular docking (XP mode of flexible docking), and the MMGBS analysis was carried out. The SPR results data demonstrated specific binding and kinetic compatibility between the SAL and Caspase-3 proteins. The results of WB revealed that compared with the model group, SAL significantly decreased (P < 0.05) expression of Cleaved Caspase-3, Caspase-3 p17, and PARP P85, and significantly increased (P < 0.05) the expression of PARP1, while the expression of Cleaved Caspase-8 and Caspase-8 p18 remained unchanged. These results suggest that Caspase-3 is a potential target for SAL to ameliorate DA which eventually plays a role in ameliorating DA by regulating apoptosis-related pathways, which provides a theoretical basis along with clues for the research and development of SAL as ameliorating DA drugs.
C1 [Wang, Hejie; Zheng, Jiangang] Changzhi Med Coll, Dept Publ Hlth & Prevent Med, Changzhi 046000, Shanxi, Peoples R China.
   [Yousaf, Wafa; Haseeb, Abdul] Shanxi Agr Univ, Coll Vet Med, Taigu 030801, Shanxi, Peoples R China.
   [Wang, Ziyang] Xinjiang Med Univ, Inst TCM, Urumqi 830000, Xinjiang, Peoples R China.
   [Wang, Hejie; Zheng, Jiangang] Shanxi Higher Educ Inst Sci & Technol Innovat Plan, Lab Environm Factors & Populat Hlth, Changzhi 046000, Peoples R China.
   [Wang, Hejie; Zheng, Jiangang] Changzhi Med Coll, Key Lab Environm Pathogen Mech & Prevent Chron Dis, Changzhi 046000, Peoples R China.
C3 Changzhi Medical College; Shanxi Agricultural University; Xinjiang
   Medical University; Changzhi Medical College
RP Zheng, JG (corresponding author), Changzhi Med Coll, Dept Publ Hlth & Prevent Med, Changzhi 046000, Shanxi, Peoples R China.; Zheng, JG (corresponding author), Shanxi Higher Educ Inst Sci & Technol Innovat Plan, Lab Environm Factors & Populat Hlth, Changzhi 046000, Peoples R China.; Zheng, JG (corresponding author), Changzhi Med Coll, Key Lab Environm Pathogen Mech & Prevent Chron Dis, Changzhi 046000, Peoples R China.
EM 1349131594@qq.com
OI Haseeb, Abdul/0009-0005-7097-9191
FU Supported by Fundamental Research Program of Shanxi Province
   [202403021222311] Funding Source: Medline; Shanxi University science and
   technology innovation plan project [2024L280, 2024L281] Funding Source:
   Medline; PhD research startup foundation of Changzhi Medical College
   [BS202306, BS202307] Funding Source: Medline
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NR 40
TC 3
Z9 3
U1 2
U2 4
PU NATURE PORTFOLIO
PI BERLIN
PA HEIDELBERGER PLATZ 3, BERLIN, 14197, GERMANY
SN 2045-2322
J9 SCI REP-UK
JI Sci Rep
PD JUL 26
PY 2025
VL 15
IS 1
AR 27294
DI 10.1038/s41598-025-12704-1
PG 15
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA 5KF2K
UT WOS:001537650500009
PM 40715275
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Gao, J
   He, H
   Jiang, WJ
   Chang, XY
   Zhu, LP
   Luo, F
   Zhou, R
   Ma, CH
   Yan, TH
AF Gao, Jin
   He, He
   Jiang, Wenjiao
   Chang, Xiayun
   Zhu, Lingpeng
   Luo, Fen
   Zhou, Rui
   Ma, Chunhua
   Yan, Tianhua
TI Salidroside ameliorates cognitive impairment in a D-galactose-induced
   rat model of Alzheimer's disease
SO BEHAVIOURAL BRAIN RESEARCH
LA English
DT Article
DE Sal; Cognitive impairment; Anti-inflammation; Anti-apoptosis
ID THIOREDOXIN-INTERACTING PROTEIN; OXIDATIVE STRESS; INFLAMMATION; CELLS;
   ACTIVATION; APOPTOSIS; PATHWAY; MICE
AB The purpose of the present study was to investigate possible preventive effects of salidroside (sal) on a rat model of Alzheimer's disease and to explore its possible mechanism. Sub-acute aging was induced in male SD rats by subcutaneous injection of D-gal (120 mg/kg) for 42 days, and the rats were treated with sal (20, 40 mg/kg) or normal saline for 28 days after 14 days of D-gal injection. Morris water maze (MWM) test and step-down passive avoidance test were conducted to evaluate the cognitive function of the rats. The levels of inflammatory cytokines including tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6) and interleukin-1 beta (IL-1 beta) in hippocampus were assayed by enzyme-linked immunosorbent assay (ELISA) to assess the anti-inflammatory effect of sal. Further, we estimated the expression levels of thioredoxin (Trx), thioredoxin interacting protein (Txnip/vitamin D3 up-regulated protein/thioredoxin binding protein-2), Bax, Bcl-2, caspase-9 and related-proteins of nuclear factor kappa B (NF-kappa B) signaling pathway by western blot assay. It showed that administration of sal significantly attenuated all the D-gal-induced changes in the hippocampus, including cognitive impairment and neuroinflammation. These analytical results provides evidence that sal can improve cognitive capacity by inhibiting neuroinflammation and affecting apoptosis-related proteins in hippocampus. (C) 2015 Elsevier B.V. All rights reserved.
C1 [Gao, Jin; He, He; Chang, Xiayun; Zhu, Lingpeng; Luo, Fen; Zhou, Rui; Ma, Chunhua; Yan, Tianhua] China Pharmaceut Univ, Dept Physiol & Pharmacol, Nanjing, Jiangsu, Peoples R China.
   [Jiang, Wenjiao] China Pharmaceut Univ, Sch Pharm, Nanjing, Jiangsu, Peoples R China.
C3 China Pharmaceutical University; China Pharmaceutical University
RP Yan, TH (corresponding author), China Pharmaceut Univ, Tongjiaxiang 24, Nanjing, Jiangsu, Peoples R China.
EM machunhua25@126.com; yantianhuabest@126.com
RI Su, Tianyuan/Y-7054-2019; he, he/JPL-3505-2023; zhou, rui/KZT-9353-2024
FU National twelve five major drug discovery project [2011ZX09102-002-01]
FX This work was supported by National twelve five major drug discovery
   project (2011ZX09102-002-01).
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NR 28
TC 155
Z9 174
U1 2
U2 77
PU ELSEVIER SCIENCE BV
PI AMSTERDAM
PA PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS
SN 0166-4328
EI 1872-7549
J9 BEHAV BRAIN RES
JI Behav. Brain Res.
PD OCT 15
PY 2015
VL 293
BP 27
EP 33
DI 10.1016/j.bbr.2015.06.045
PG 7
WC Behavioral Sciences; Neurosciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Behavioral Sciences; Neurosciences & Neurology
GA CR8BP
UT WOS:000361576400004
PM 26192909
DA 2026-05-27
ER

PT J
AU Ma, GP
   Zheng, Q
   Xu, MB
   Zhou, XL
   Lu, L
   Li, ZX
   Zheng, GQ
AF Ma, Gou-ping
   Zheng, Qun
   Xu, Meng-bei
   Zhou, Xiao-li
   Lu, Lin
   Li, Zuo-xiao
   Zheng, Guo-Qing
TI Rhodiola rosea L. Improves Learning and Memory Function:
   Preclinical Evidence and Possible Mechanisms
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Review
DE Rhodiola rosea L.; salidroside; learning and memory; cognition;
   preclinical evidence; possible mechanisms
ID ALZHEIMERS-DISEASE; SALIDROSIDE; EXTRACT; METAANALYSIS; IMPAIRMENT;
   PLACEBO; RATS; STRESS; MODELS; TRIAL
AB Rhodiola rosea L. (R. rosea L.) is widely used to stimulate the nervous system, extenuate anxiety, enhance work performance, relieve fatigue, and prevent high altitude sickness. Previous studies reported that R. rosea L. improves learning and memory function in animal models. Here, we conducted a systematic review and meta-analysis for preclinical studies to assess the current evidence for R. rosea L. effect on learning and memory function. Ultimately, 36 studies involving 836 animals were identified by searching 6 databases from inception to May 2018. The primary outcome measures included the escape latency in Morris water maze (MWM) test on behalf of learning ability, the frequency and the length of time spent on the target quadrant in MWM test representing memory function, and the number of errors in step down test, dark avoidance test and Y maze test on behalf of memory function. The secondary outcome measures were mechanisms of R. rosea L. for learning and/or memory function. Compared with control, the pooled results of 28 studies showed significant effects of R. rosea L. for reducing the escape latency (P < 0.05); 23 studies for increasing the frequency and the length of time spent on the target quadrant (P < 0.05); and 6 studies for decreasing the number of errors (P < 0.01). The possible mechanisms of R. rosea L. are largely through antioxidant, cholinergic regulation, anti-apoptosis activities, anti-inflammatory, improving coronary blood flow, and cerebral metabolism. In conclusion, the findings suggested that R. rosea L. can improve learning and memory function.
C1 [Ma, Gou-ping] Tongde Hosp Zhejiang Prov, Hangzhou, Zhejiang, Peoples R China.
   [Zheng, Qun; Xu, Meng-bei; Zhou, Xiao-li; Zheng, Guo-Qing] Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 2, Wenzhou, Peoples R China.
   [Zheng, Qun; Xu, Meng-bei; Zhou, Xiao-li; Zheng, Guo-Qing] Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.
   [Lu, Lin] Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China.
   [Li, Zuo-xiao] Southwest Med Univ, Dept Neurol, Affiliated Hosp, Luzhou, Peoples R China.
C3 Tongde Hospital of Zhejiang Province; Wenzhou Medical University;
   Wenzhou Medical University; Hong Kong Baptist University; Southwest
   Medical University
RP Zheng, GQ (corresponding author), Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 2, Wenzhou, Peoples R China.; Zheng, GQ (corresponding author), Wenzhou Med Univ, Yuying Childrens Hosp, Wenzhou, Peoples R China.; Lu, L (corresponding author), Hong Kong Baptist Univ, Sch Chinese Med, Hong Kong, Hong Kong, Peoples R China.; Li, ZX (corresponding author), Southwest Med Univ, Dept Neurol, Affiliated Hosp, Luzhou, Peoples R China.
EM lulinlc@126.com; lzx3235@sina.com; gq_zheng@sohu.com
RI Zheng, Guo-qing/A-4412-2019; zheng, qun/JAX-5110-2023; Xiaoli,
   Zhou/KOD-3921-2024
OI Zheng, Guo-qing/0000-0001-5286-5696; 
FU National Natural Science Foundation of China
   [81573750/81473491/81173395/H2902]
FX This project was supported by the grant of National Natural Science
   Foundation of China (81573750/81473491/81173395/H2902).
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NR 62
TC 28
Z9 34
U1 0
U2 31
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
SN 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD DEC 4
PY 2018
VL 9
AR 1415
DI 10.3389/fphar.2018.01415
PG 18
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA HC8LD
UT WOS:000452053400002
PM 30564123
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Lang, ZC
   Li, YF
   Lin, LF
   Li, XM
   Tao, QQ
   Hu, YH
   Bao, ML
   Zheng, L
   Yu, ZP
   Zheng, JJ
AF Lang, Zhichao
   Li, Yifei
   Lin, Lifan
   Li, Xinmiao
   Tao, Qiqi
   Hu, Yuhang
   Bao, Menglu
   Zheng, Lei
   Yu, Zhengping
   Zheng, Jianjian
TI Hepatocyte-derived exosomal miR-146a-5p inhibits hepatic stellate cell
   EMT process: a crosstalk between hepatocytes and hepatic stellate cells
SO CELL DEATH DISCOVERY
LA English
DT Article
ID MESENCHYMAL TRANSITIONS; LIVER FIBROSIS; SALIDROSIDE; MECHANISMS;
   AUTOPHAGY
AB Recently, Salidroside (Sal) has been demonstrated to suppress hepatic stellate cell (HSC) activation, a crucial event for liver fibrosis. Moreover, Sal has been reported to decrease hepatocyte injury. A growing number of reports have indicated that the crosstalk between hepatocytes and HSCs is very crucial for liver fibrosis development. Whether Sal-treated hepatocytes could inhibit HSC activation is unclear. Exosomes, as vital vehicles of intercellular communication, have been shown to transfer cargos between hepatocytes and HSCs. Herein, we aimed to investigate the roles of exosomal miRNAs from Sal-treated hepatocytes in HSC activation as well as liver fibrosis. Our results showed that Sal suppressed carbon tetrachloride (CCl4)-induced liver fibrosis in vivo. HSC activation as well as cell proliferation was repressed in HSCs co-cultured with Sal-treated hepatocytes. Interestingly, miR-146a-5p was up-regulated by Sal in CCl4-treated mice. Also, enhanced miR-146a-5p was found in hepatocytes isolated from Sal-treated CCl4 mice and hepatocyte-derived exosomes. Notably, hepatocyte exosomal miR-146a-5p contributed to HSC inactivation. Inhibiting miR-146a-5p in hepatocyte exosomes resulted in reduced E-cadherin (E-cad) and increased desmin in HSCs, indicating that miR-146a-5p caused HSC inactivation via epithelial-mesenchymal transition (EMT). miR-146a-5p inhibition-mediated HSC activation and EMT process were blocked down by loss of EIF5A2. Further studies revealed that EIF5A2 was a target of miR-146a-5p. Furthermore, exosomes with miR-146a-5p overexpression inhibited liver fibrosis in CCl4 mice. Collectively, exosomal miR-146a-5p from Sal-treated hepatocytes inhibits HSC activation and liver fibrosis, at least in part, by suppressing EIF5A2 and EMT process.
C1 [Lang, Zhichao; Li, Yifei; Lin, Lifan; Li, Xinmiao; Tao, Qiqi; Bao, Menglu; Zheng, Lei; Zheng, Jianjian] Wenzhou Med Univ, Affiliated Hosp 1, Key Lab Clin Lab Diag & Translat Res Zhejiang Prov, Wenzhou 325000, Peoples R China.
   [Hu, Yuhang; Zheng, Jianjian] Wenzhou Med Univ, Cixi Biomed Res Inst, Ningbo 315000, Peoples R China.
   [Zheng, Lei] Southern Med Univ, Nanfang Hosp, Lab Med Ctr, Guangzhou 510515, Peoples R China.
   [Yu, Zhengping] Wenzhou Med Univ, Affiliated Hosp 1, Dept Hepatobiliary Surg, Wenzhou 325000, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Southern Medical
   University - China; Wenzhou Medical University
RP Zheng, JJ (corresponding author), Wenzhou Med Univ, Affiliated Hosp 1, Key Lab Clin Lab Diag & Translat Res Zhejiang Prov, Wenzhou 325000, Peoples R China.; Zheng, JJ (corresponding author), Wenzhou Med Univ, Cixi Biomed Res Inst, Ningbo 315000, Peoples R China.
EM zjj@wmu.edu.cn
RI yu, zheng/PDX-9565-2025; li, yifei/IWU-7824-2023
OI Zheng, Jianjian/0000-0001-8770-4219
FU National Natural Science Foundation of China [81873576]; Wenzhou
   Municipal Science and technology Bureau [Y20220023]; Key Laboratory of
   Clinical Laboratory Diagnosis and Translational Research of Zhejiang
   Province [2022E10022]; Wenzhou Medical University Basic Scientific
   Research [KYYW201904]; Zhejiang Provincial Medical and Health Planning
   Project [2023KY898]; Zhejiang Provincial Research Centre for Diagnosis
   and Treatment of Critical Liver and Biliary Diseases (Minimally
   Invasive); National Key Clinical Specialty (General Surgery), First
   Affiliated Hospital Of Wenzhou Medical University
FX The project was supported by the National Natural Science Foundation of
   China (No.81873576), Wenzhou Municipal Science and technology Bureau
   (No. Y20220023), Key Laboratory of Clinical Laboratory Diagnosis and
   Translational Research of Zhejiang Province (No. 2022E10022), Wenzhou
   Medical University Basic Scientific Research(No.KYYW201904), Zhejiang
   Provincial Medical and Health Planning Project (No.2023KY898),Zhejiang
   Provincial Research Centre for Diagnosis and Treatment of Critical Liver
   and Biliary Diseases (Minimally Invasive) and National Key Clinical
   Specialty (General Surgery), The First Affiliated Hospital Of Wenzhou
   Medical University.
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NR 45
TC 19
Z9 21
U1 3
U2 21
PU SPRINGERNATURE
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON, N1 9XW, ENGLAND
EI 2058-7716
J9 CELL DEATH DISCOV
JI Cell Death Discov.
PD AUG 19
PY 2023
VL 9
IS 1
AR 304
DI 10.1038/s41420-023-01602-y
PG 12
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA P6BN9
UT WOS:001051509600002
PM 37598186
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Xu, DH
   Ai, QD
   Chen, XQ
   Wang, ZG
   Wei, HD
   Zhou, LB
   Mei, ZG
   Ge, JW
AF Xu, Dehong
   Ai, Qidi
   Chen, Xiaoqing
   Wang, Zhaoguo
   Wei, Hongda
   Zhou, Luobing
   Mei, Zhigang
   Ge, Jinwen
TI Metabonomics Study on Naotaifang Extract Alleviating Neuronal Apoptosis
   after Cerebral Ischemia-Reperfusion Injury
SO EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
LA English
DT Article
ID MECHANISMS; HIPPOCAMPUS; EXPRESSION; CALYCOSIN; ADENOSINE; RATS
AB Naotaifang extract (NTE) is a clinically effective traditional Chinese medicine compound for cerebral ischemia-reperfusion injury. Although NTE can achieve neuroprotective function through different mechanisms, the pharmacodynamic substances of NTE corresponding to these mechanisms have rarely been reported. Alleviating or inhibiting neuronal apoptosis is an important way to achieve neuroprotection. Accordingly, this study has evaluated the effects of NTE on alleviating neuronal apoptosis after cerebral ischemia-reperfusion injury from two levels of cells and tissues. Meanwhile, the serum pharmacochemistry of NTE was analyzed by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) with the guidance of Chinmedomics. The results included three aspects: (1) NTE could significantly alleviate neuronal apoptosis caused by in vitro cellular models and in vivo animal models; (2) a total of 21 serum differential metabolites was discovered, including adenosine, inosine, ferulic acid, calycosin, salidroside, 6-gingerol, 2-methoxycinnamaldehyde, and so on; (3) the metabolic pathway regulated by NTE was mainly purine metabolism. From these results, it can be concluded that alleviating neuronal apoptosis by NTE after cerebral ischemia-reperfusion injury is one of the important mechanisms to achieve neuroprotection. The pharmacodynamic substances of NTE for alleviating neuronal apoptosis on the one hand are related to components directly absorbed into blood, such as ferulic acid, calycosin, salidroside, 6-gingerol, and 2-methoxycinnamaldehyde and on the other hand are also closely linked to its indirect regulation of purine metabolism in the body to produce adenosine and inosine. Therefore, our research not only identified the main pharmacodynamic substances of NTE that alleviated neuronal apoptosis but also provided a methodological reference for studying other neuroprotective effects of NTE.
C1 [Xu, Dehong; Mei, Zhigang; Ge, Jinwen] Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.
   [Xu, Dehong; Ai, Qidi; Chen, Xiaoqing; Wang, Zhaoguo; Wei, Hongda; Zhou, Luobing] Hunan Univ Chinese Med, Coll Pharm, Lab Biol Engn, Changsha 410208, Hunan, Peoples R China.
   [Ge, Jinwen] Shaoyang Univ, Sch Med, Shaoyang 422000, Hunan, Peoples R China.
C3 Hunan University of Chinese Medicine; Hunan University of Chinese
   Medicine; Shaoyang University
RP Mei, ZG; Ge, JW (corresponding author), Hunan Univ Chinese Med, Coll Integrated Tradit Chinese & Western Med, Changsha 410208, Hunan, Peoples R China.; Ge, JW (corresponding author), Shaoyang Univ, Sch Med, Shaoyang 422000, Hunan, Peoples R China.
EM meizhigang@hnucm.edu.cn; 001267@hnucm.edu.cn
RI wang, zhaoguo/GRX-7405-2022; Mei, Zhigang/ABB-6118-2021; Ai,
   Qidi/AGS-8732-2022
OI Xu, Dehong/0000-0001-9739-2191
FU National Natural Science Foundation of China [82104324, 81774033,
   81774174]; Scientific Research Project of Hunan Provincial Department of
   Education [19C1407]; Scientific Research Foundation of Hunan University
   of Traditional Chinese Medicine [2020XJJJ030]; Key Discipline of
   Biological Engineering of Hunan University of Chinese Medicine [3];
   Scientific Research Foundation of Hunan Key Laboratory of Chinese
   Materia Medica Powder and Innovative Drugs Established by Provincial and
   Ministry [1]
FX This work was supported by the National Natural Science Foundation of
   China (82104324, 81774033, and 81774174), Scientific Research Project of
   Hunan Provincial Department of Education (19C1407), Scientific Research
   Foundation of Hunan University of Traditional Chinese Medicine
   (2020XJJJ030), The Key Discipline of Biological Engineering of Hunan
   University of Chinese Medicine ([2018] No. 3), and Scientific Research
   Foundation of Hunan Key Laboratory of Chinese Materia Medica Powder and
   Innovative Drugs Established by Provincial and Ministry ([2020] no. 1).
CR Borea PA, 2016, TRENDS PHARMACOL SCI, V37, P419, DOI 10.1016/j.tips.2016.02.006
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NR 38
TC 8
Z9 11
U1 0
U2 36
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1741-427X
EI 1741-4288
J9 EVID-BASED COMPL ALT
JI Evid.-based Complement Altern. Med.
PD MAR 14
PY 2022
VL 2022
AR 2112433
DI 10.1155/2022/2112433
PG 12
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA 0U3XE
UT WOS:000787584700002
PM 35321499
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Li, M
   Zhang, B
   Lu, XY
   Xie, CM
   Weng, J
   Qu, SX
AF Li, Mian
   Zhang, Bing
   Lu, Xiaoying
   Xie, Chaoming
   Weng, Jie
   Qu, Shuxin
TI Dual surface modification strategies for enhanced osteogenesis of
   titanium through the biomimetic Haversian osteon with deposited CaP to
   assemble salidroside
SO COLLOIDS AND SURFACES B-BIOINTERFACES
LA English
DT Article
DE Titanium; Surface modification; Biomimetic Haversian osteon;
   Micro-/nano-structure; Osteogenic differentiation
ID TIO2 NANOTUBE ARRAYS; OSTEOBLAST DIFFERENTIATION; HYDROXYAPATITE
   PARTICLES; BONE; NANOMATERIALS; FABRICATION; MORPHOLOGY; PROTEINS;
   ADHESION; PATHWAY
AB Titanium (Ti) and Ti alloy are the most widely used implant metals, but the limited bioactivity hinders the further clinical application. Aiming to enhance their osteogenesis, dual biomimetic strategies were utilized to decorate the surface of Ti by topological and biochemical cues. Firstly, a series of concentric circles with TiO2 nanotubes on Ti were fabricated by photolithography and anodic oxidation. Furthermore, hydrothermal deposition and vacuum adsorption were adopted to introduce CaP and then assemble natural product of salidroside (Sal) on TiO2 nanotubes (Sal/CaP/BTNT). Sal/CaP/BTNT was not only bio-mimicked the features of Haversian osteon in size and composition, but also slowed the release of Sal simultaneously. This biomimetic Haversian osteon induced bone marrow mesenchymal stem cells (BMSCs) to grow along the concentric circles, and was involved in BMP, Wnt/beta-catenin, Notch and mechanical signaling pathways. Particularly, the expressions of related genes were up-regulated nearly to 200 % in mechanical signaling pathway compared to that of pure BMSCs. Additional, Sal enhanced osteogenic differentiation of BMSCs via BMP signaling pathway. The dual biomimetic Haversian osteon could promote the proliferation, differentiation and mineralization of BMSCs compared to that of pure BMSCs. In vivo studies showed that the CaP/BTNT and Sal/CaP/BTNT both promoted more new-bone formation than that of the control groups, indicating of their accelerated osseointegration due to the dual biomimetic Haversian osteon. The dual biomimetic strategies endowed Ti the excellent osteogenesis, which provided a promising surface modification strategy of Ti and Ti alloy to accelerate osteogenesis in clinic.
C1 [Li, Mian; Zhang, Bing; Lu, Xiaoying; Xie, Chaoming; Weng, Jie; Qu, Shuxin] Southwest Jiaotong Univ, Inst Biomed Engn, Coll Med, Chengdu 610031, Sichuan, Peoples R China.
   [Li, Mian; Zhang, Bing] Southwest Jiaotong Univ, Sch Mat Sci & Engn, Key Lab Adv Technol Mat, Minist Educ, Chengdu 610031, Sichuan, Peoples R China.
C3 Southwest Jiaotong University; Southwest Jiaotong University
RP Qu, SX (corresponding author), Southwest Jiaotong Univ, Inst Biomed Engn, Coll Med, Chengdu 610031, Sichuan, Peoples R China.
EM qushuxin@swjtu.edu.cn
RI ; Li, Mian/H-6538-2011; Xie, Chaoming/AAB-7403-2020
OI Qu, shuxin/0000-0001-9049-9332; 
FU National Natural Science Foundation of China [52035012]; Science and
   Technology Department of Sichuan Province [2024YFHZ0337]; Fundamental
   Research Funds for the Cen-tral Universities [2682024ZTPY004]; Chengdu
   Municipal Health Com-mission [2023040]
FX This work was supported by National Natural Science Foundation of China
   (52035012) , Science and Technology Department of Sichuan Province
   (2024YFHZ0337) , Fundamental Research Funds for the Cen-tral
   Universities (2682024ZTPY004) , Chengdu Municipal Health Com-mission
   (2023040) . We would like to thank the Analysis and Testing Center of
   Southwest Jiaotong University to characterize morphology and phase of
   the materials.
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NR 77
TC 1
Z9 1
U1 8
U2 12
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0927-7765
EI 1873-4367
J9 COLLOID SURFACE B
JI Colloid Surf. B-Biointerfaces
PD DEC
PY 2025
VL 256
AR 115085
DI 10.1016/j.colsurfb.2025.115085
EA SEP 2025
PN 2
PG 11
WC Biophysics; Chemistry, Physical; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biophysics; Chemistry; Materials Science
GA 7CK4R
UT WOS:001567700800002
PM 40897154
DA 2026-05-27
ER

PT J
AU Kosakowska, O
   Baczek, K
   Przybyl, JL
   Pióro-Jabrucka, E
   Czupa, W
   Synowiec, A
   Gniewosz, M
   Costa, R
   Mondello, L
   Weglarz, Z
AF Kosakowska, Olga
   Baczek, Katarzyna
   Przybyl, Jaroslaw L.
   Pioro-Jabrucka, Ewelina
   Czupa, Weronika
   Synowiec, Alicja
   Gniewosz, Malgorzata
   Costa, Rosaria
   Mondello, Luigi
   Weglarz, Zenon
TI Antioxidant and Antibacterial Activity of Roseroot (Rhodiola
   rosea L.) Dry Extracts
SO MOLECULES
LA English
DT Article
DE roseroot; underground organs; dry extracts; salidroside; rosavins;
   essential oil; geraniol; antioxidant power; antibacterial activity
ID TANACETUM-VULGARE L.; ESSENTIAL OILS; LIQUID-CHROMATOGRAPHY;
   CHEMICAL-COMPOSITION; PRODUCTS; RHIZOMES; QUALITY; PLANTS; ROOTS; CELLS
AB Roseroot (Rhodiola rosea L.) belongs to plants revealing adaptogenic properties, which are attributed to the presence of specific phenolic compounds and are reflected mainly as antioxidant activity. The aim of the present study was to determine the antioxidant and antibacterial activity of various products obtained from R. rosea (underground organs as well as their aqueous and ethanolic dry extracts) in relation to the chemical profiles of phenolic and essential oil compounds. The chemical profiles were determined by High-performance Liquid Chromatography with a diode-array detector (HPLC-DAD) and Gas chromatography-mass spectrometry (GC-MS), antioxidant activity by (1,1-Diphenyl-2-picrylhydrazyl) Scavenging Capacity Assay (DPPH), (2,2-Azino-bis(3-ethylbenzothiazoline-6-sulphonic acid)) Scavenging Capacity Assay (ABTS) and Ferric Reducing Antioxidant Power Assay (FRAP) and antimicrobial properties were expressed as minimum inhibitory concentration (MIC) and minimum bacterial concentration (MBC) values following the broth microdilutions method. The results show that the investigated samples differed in terms of their chemical compositions and biological activities. The extracts were more abundant in phenolic compounds (salidroside, tyrosol, and rosavin derivatives) in comparison to dried underground organs. The content of the determined phenolics in the analyzed extracts was affected by the solvent used for extraction. The ethanolic extract was characterized by the highest content of these substances in comparison to the aqueous one and the dried raw material, especially with regard to rosavin (969.71 mg/100 g). In parallel, this extract showed the strongest antioxidant and antibacterial activity. However, dried R. rosea underground organs also revealed strong antibacterial effects against, for example, Staphylococcus strains.
C1 [Kosakowska, Olga; Baczek, Katarzyna; Przybyl, Jaroslaw L.; Pioro-Jabrucka, Ewelina; Czupa, Weronika; Weglarz, Zenon] Warsaw Univ Life Sci SGGW, Fac Hort Biotechnol & Landscape Architecture, Dept Vegetable & Med Plants, Lab New Herbal Prod, PL-02776 Warsaw, Poland.
   [Synowiec, Alicja; Gniewosz, Malgorzata] Warsaw Univ Life Sci SGGW, Fac Food Sci, Dept Biotechnol Microbiol & Food Evaluat, Div Food Biotechnol & Microbiol, PL-02776 Warsaw, Poland.
   [Costa, Rosaria] Univ Messina, Dipartimento Sci Biomed Odontoiatr & Immagini Mor, I-98122 Messina, Italy.
   [Mondello, Luigi] Univ Messina, Dipartimento Sci Chim Biol Farmaceut & Ambientali, I-98122 Messina, Italy.
   [Mondello, Luigi] Chromaleont Srl, I-98122 Messina, Italy.
C3 Warsaw University of Life Sciences; Warsaw University of Life Sciences;
   University of Messina; University of Messina
RP Kosakowska, O (corresponding author), Warsaw Univ Life Sci SGGW, Fac Hort Biotechnol & Landscape Architecture, Dept Vegetable & Med Plants, Lab New Herbal Prod, PL-02776 Warsaw, Poland.
EM olga_kosakowska@sggw.pl; katarzyna_baczek@sggw.pl;
   jaroslaw_przybyl@sggw.pl; ewelina_pioro_jabrucka@sggw.pl;
   w.czupa@gmail.com; alicja_synowiec@sggw.pl; malgorzata_gniewosz@sggw.pl;
   costar@unime.it; lmondello@unime.it; zenon_weglarz@sggw.pl
RI ; Bączek, Katarzyna/F-7861-2013; Kosakowska, Olga/U-7740-2018; Węglarz,
   Zenon/F-7871-2013; Mondello, Luigi/C-6891-2008; Przybył,
   Jarosław/A-4874-2012; , Gniewosz/AFZ-2764-2022
OI Gniewosz, Małgorzata/0000-0003-2282-8231; Bączek,
   Katarzyna/0000-0003-3061-6474; , Ewelina
   Pióro-Jabrucka/0000-0002-8593-0906; Kosakowska,
   Olga/0000-0001-7376-3277; Węglarz, Zenon/0000-0002-8992-8061; Mondello,
   Luigi/0000-0002-8890-675X; Przybył, Jarosław/0000-0003-0959-184X;
   Synowiec, Alicja/0000-0002-2512-8567; 
FU Polish Ministry of Agriculture and Rural Development within the
   Multiannual Programme "Creating the scientific basis of the biological
   progress and conservation of plant genetic resources as a source of
   innovation to support sustainable agriculture and foo
FX Parts of this study were supported by Polish Ministry of Agriculture and
   Rural Development within the Multiannual Programme "Creating the
   scientific basis of the biological progress and conservation of plant
   genetic resources as a source of innovation to support sustainable
   agriculture and food security of the country 2015-2020".
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NR 49
TC 55
Z9 68
U1 0
U2 32
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD JUL
PY 2018
VL 23
IS 7
AR 1767
DI 10.3390/molecules23071767
PG 14
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA GU5CE
UT WOS:000445301800270
PM 30022015
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Fotiadou, R
   Bellou, MG
   Spyrou, K
   Yan, F
   Rudolf, P
   Gournis, D
   Stamatis, H
AF Fotiadou, Renia
   Bellou, Myrto G.
   Spyrou, Konstantinos
   Yan, Feng
   Rudolf, Petra
   Gournis, Dimitrios
   Stamatis, Haralambos
TI Effect of deep eutectic solvents on the biocatalytic properties of β-
   glucosidase@ZnOFe nano-biocatalyst
SO SUSTAINABLE CHEMISTRY AND PHARMACY
LA English
DT Article
DE Green solvents; Biocatalysis; Immobilization; Green nanomaterials
ID ENZYMATIC-SYNTHESIS; NANOPARTICLES; BIOSYNTHESIS; SALIDROSIDE; TYROSOL;
   LACCASE
AB In this work, we investigate the use of aqueous deep eutectic solvents (DESs) consisting of differ-ent hydrogen bond acceptors (choline chloride, ammonium salts or betaine) and hydrogen bond donors (amines, sugars and alcohols), as co-solvents in biocatalytic reactions catalyzed by a nano-biocatalyst with beta-glucosidase (BGL) activity. For this purpose, beta-glucosidase from Thermotoga maritima was immobilized on the surface of green zinc oxide-iron oxide nanoparticles (BGL@ZnOFe) derived from an aqueous olive leaf extract. The covalent bonding of beta-glucosidase on the surface of nanoparticles was demonstrated by X-ray photoelectron spectroscopy. The ef-fect of a wide range of DES solutions on the biocatalytic features of BGL@ZnOFe was thoroughly investigated. The concentration of DES as well as the specific combination of hydrogen bond ac-ceptors and hydrogen bond donors had a significant impact on the hydrolytic activity of immobi-lized beta-glucosidase. Most choline chloride and betaine-based DESs enhanced the enzymatic activ-ity and thermal stability of BGL@ZnOFe up to 50%. The enzymatic activity of the nano-biocatalyst towards the hydrolysis of bioactive phenolic compounds depends on the nature of the DES used. Choline chloride:butylene glycol-based medium had beneficial effect on a transglyco-sylation reaction, such as the synthesis of salidroside, increasing the total turnover number of the biocatalytic process by 55%. This work indicates that the use of several choline chloride and be-taine-based DESs can be successfully employed as green co-solvents in various hydrolytic and synthetic biocatalytic processes.
C1 [Fotiadou, Renia; Bellou, Myrto G.; Stamatis, Haralambos] Univ Ioannina, Dept Biol Applicat & Technol, Biotechnol Lab, Ioannina 45110, Greece.
   [Spyrou, Konstantinos; Gournis, Dimitrios] Univ Ioannina, Dept Mat Sci & Engn, Ioannina 45110, Greece.
   [Yan, Feng; Rudolf, Petra] Univ Groningen, Zernike Inst Adv Mat, Nijenborgh 4, NL-9747 AG Groningen, Netherlands.
C3 University of Ioannina; University of Ioannina; University of Groningen
RP Stamatis, H (corresponding author), Univ Ioannina, Dept Biol Applicat & Technol, Biotechnol Lab, Ioannina 45110, Greece.
EM renia.fotiadou@gmail.com; myrtobell@gmail.com;
   konstantinos.spyrou1@gmail.com; f.yan.rug@gmail.com; p.rudolf@rug.nl;
   dgourni@uoi.gr; hstamati@uoi.gr
RI Stamatis, Haralambos/ACN-1086-2022; Gournis, Dimitrios/K-3410-2016;
   Rudolf, Petra/E-6434-2014; Spyrou, Konstantinos/M-5935-2018; Fotiadou,
   Renia/KOD-6935-2024
OI Stamatis, Haralambos/0000-0002-8196-4885; Bellou,
   Myrto/0009-0007-0264-1767; Rudolf, Petra/0000-0002-4418-1769; Spyrou,
   Konstantinos/0000-0002-2032-8439; Fotiadou, Renia/0000-0003-3958-6830
FU European Regional Development Fund of the European Union; Greek national
   funds through the Operational Program Competitiveness, Entrepreneurship
   and Innovation, under the call RE- SEARCH-CREATE-INNOVATE [T2EDK-03599];
   Empirikion Foundation (Greece)
FX This research has been co-financed by the European Regional Development
   Fund of the European Union and Greek national funds through the
   Operational Program Competitiveness, Entrepreneurship and Innovation,
   under the call RE- SEARCH-CREATE-INNOVATE (project code: T2EDK-03599) .
   Financial support from the Empirikion Foundation (Greece) is gratefully
   acknowledged.
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NR 50
TC 15
Z9 15
U1 1
U2 23
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
EI 2352-5541
J9 SUSTAIN CHEM PHARM
JI SUSTAIN. CHEM. PHARM.
PD DEC
PY 2022
VL 30
AR 100886
DI 10.1016/j.scp.2022.100886
EA NOV 2022
PG 12
WC Chemistry, Multidisciplinary; Green & Sustainable Science & Technology;
   Environmental Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry; Science & Technology - Other Topics; Environmental Sciences &
   Ecology
GA 7C5VH
UT WOS:000899879700009
OA Green Submitted, Green Published
DA 2026-05-27
ER

PT J
AU Qi, T
   Ge, BK
   Zhao, L
   Ma, Y
   Li, XR
   Xu, PX
   Xue, M
AF Qi, Te
   Ge, Bei-kang
   Zhao, Liang
   Ma, Yi
   Li, Xiao-rong
   Xu, Ping-xiang
   Xue, Ming
TI Cytosolic -glucosidase inhibition and renal blood flow suppression are
   leading causes for the enhanced systemic exposure of salidroside in
   hypoxic rats
SO RSC ADVANCES
LA English
DT Article
ID PERFORMANCE LIQUID-CHROMATOGRAPHY; INTESTINAL ACTIVE ABSORPTION; TANDEM
   MASS-SPECTROMETRY; P-AMINOHIPPURIC ACID; SIMULTANEOUS QUANTIFICATION;
   METABOLISM; PLASMA; DEGLYCOSYLATION; IDENTIFICATION; DISPOSITION
AB The promising benefits of salidroside (SAL) in alleviating high altitude sickness boost investigations on its pharmacokinetics and biological activity. However, the transportation and disposition process of SAL under hypoxic conditions has never been explored. The current study was proposed to investigate the pharmacokinetics of SAL in hypoxic rats and to explore the underlying mechanisms for the distinct metabolic fate of SAL under hypoxia. Pharmacokinetic studies on SAL was conducted in both hypoxic and normoxic rats. The transport properties of SAL were investigated on both hypoxic and normoxic Caco-2 monolayer models. Enzymes involved in SAL metabolism were identified and the effects of hypoxia on these enzymes were assessed by real-time PCR, western blotting analyses, and rat liver homogenate incubation. The renal clearance (CLr) of SAL, effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) in both hypoxic and normoxic rats were also determined for renal function assessment. It was found that the systemic exposure of SAL in hypoxic rats was remarkably higher than that in normoxic rats. The barrier function of Caco-2 monolayer was weakened under hypoxia due to the impaired brush border microvilli and decreased expression of tight junction protein. Hepatic metabolism of SAL in hypoxic rats was attenuated due to the reduced activity of cytosolic -glucosidase (CBG). Moreover, CLr of SAL was reduced in hypoxic rats due to the suppressed ERPF. Our findings suggest the potential need for dose-adjustment of SAL or its structural analogs under hypoxic conditions.
C1 [Qi, Te; Ge, Bei-kang; Zhao, Liang; Ma, Yi; Li, Xiao-rong; Xu, Ping-xiang; Xue, Ming] Capital Med Univ, Beijing Lab Biomed Detect Technol & Instrument, Dept Pharmacol, Sch Basic Med Sci, Beijing, Peoples R China.
C3 Capital Medical University
RP Xue, M (corresponding author), Capital Med Univ, Beijing Lab Biomed Detect Technol & Instrument, Dept Pharmacol, Sch Basic Med Sci, Beijing, Peoples R China.
EM xuem@ccmu.edu.cn
FU National Natural Science Foundation of China [81573683, 81173121]
FX The authors thank Yao-nan Wang, Shu-rui Zhao, and Kui Luo in the core
   facilities center of Capital Medical University for the technical
   assistance in mass spectrometry analysis. This work was supported by
   National Natural Science Foundation of China (Grant 81573683 and
   81173121).
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NR 38
TC 14
Z9 14
U1 0
U2 5
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
EI 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2018
VL 8
IS 16
BP 8469
EP 8483
DI 10.1039/c7ra13295f
PG 15
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA FY3HS
UT WOS:000426710300003
PM 35539855
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Zou, H
   Liu, XZ
   Han, T
   Hu, D
   Wang, Y
   Yuan, Y
   Gu, JH
   Bian, JC
   Zhu, JQ
   Liu, ZP
AF Zou, Hui
   Liu, Xuezhong
   Han, Tao
   Hu, Di
   Wang, Yi
   Yuan, Yan
   Gu, Jianhong
   Bian, Jianchun
   Zhu, Jiaqiao
   Liu, Zong-ping
TI Salidroside Protects against Cadmium-Induced Hepatotoxicity in Rats via
   GJIC and MAPK Pathways
SO PLOS ONE
LA English
DT Article
ID JUNCTIONAL INTERCELLULAR COMMUNICATION; H2O2-INDUCED INHIBITION;
   GAP-JUNCTION; CELL-DEATH; APOPTOSIS; LIVER; CONNEXINS; CHANNELS; KINASE;
   DAMAGE
AB It is known that cadmium (Cd) induces cytotoxicity in hepatocytes; however, the underlying mechanism is unclear. Here, we studied the molecular mechanisms of Cd-induced hepatotoxicity in rat liver cells (BRL 3A) and in vivo. We observed that Cd treatment was associated with a time-and concentration-dependent decrease in the cell index (CI) of BRL 3A cells and cellular organelle ultrastructure injury in the rat liver. Meanwhile, Cd treatment resulted in the inhibition of gap junction intercellular communication (GJIC) and activation of mitogen-activated protein kinase (MAPK) pathways. Gap junction blocker 18-beta-glycyrrhetinic acid (GA), administered in combination with Cd, exacerbated cytotoxic injury in BRL 3A cells; however, GA had a protective effect on healthy cells co-cultured with Cd-exposed cells in a co-culture system. Cd-induced cytotoxic injury could be attenuated by co-treatment with an extracellular signal-regulated kinase (ERK) inhibitor (U0126) and a p38 inhibitor (SB202190) but was not affected by co-treatment with a c-Jun N-terminal kinase (JNK) inhibitor (SP600125). These results indicate that ERK and p38 play critical roles in Cd-induced hepatotoxicity and mediate the function of gap junctions. Moreover, MAPKs induce changes in GJIC by controlling connexin gene expression, while GJIC has little effect on the Cd-induced activation of MAPK pathways. Collectively, our study has identified a possible mechanistic pathway of Cd-induced hepatotoxicity in vitro and in vivo, and identified the participation of GJIC and MAPK-mediated pathways in Cd-induced hepatotoxicity. Furthermore, we have shown that salidroside may be a functional chemopreventative agent that ameliorates the negative effects of Cd via GJIC and MAPK pathways.
C1 [Zhu, Jiaqiao] Yangzhou Univ, Coll Vet Med, Yangzhou 225009, Jiangsu, Peoples R China.
   Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Jiangsu, Peoples R China.
C3 Yangzhou University; Yangzhou University
RP Zhu, JQ (corresponding author), Yangzhou Univ, Coll Vet Med, Yangzhou 225009, Jiangsu, Peoples R China.
EM jqzhu1998@163.com; liuzongping@yzu.edu.cn
RI ; Gu, Jianhong/B-5316-2011
OI YUAN, YAN/0000-0002-1658-5328; 
FU National Natural Science Foundation of China [31101866, 31172373,
   31302058]; Priority Academic Program Development of Jiangsu Higher
   Education Institutions (PAPD)
FX This work was supported by the National Natural Science Foundation of
   China (No. 31101866 to Yan Yuan; No. 31172373 to Zong-ping Liu; No.
   31302058 to Yi Wang) (http://www.nsfc.gov.cn/Portal0/default152.htm) and
   a project Funded by Priority Academic Program Development of Jiangsu
   Higher Education Institutions (PAPD) (http://jsycw.ec.js.edu.cn/). The
   funders had no role in study design, data collection and analysis,
   decision to publish, or preparation of the manuscript.
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NR 53
TC 31
Z9 34
U1 1
U2 28
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD JUN 12
PY 2015
VL 10
IS 6
AR e0129788
DI 10.1371/journal.pone.0129788
PG 14
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CK6GR
UT WOS:000356327000105
PM 26070151
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Pan, JY
   Zhu, J
   Li, L
   Zhang, T
   Xu, ZY
AF Pan, Jiaying
   Zhu, Jie
   Li, Liang
   Zhang, Tao
   Xu, Zhenyu
TI Salidroside attenuates LPS-induced kidney injury through activation of
   SIRT1/Nrf2 pathway
SO HUMAN & EXPERIMENTAL TOXICOLOGY
LA English
DT Article
DE Acute kidney injury; salidroside; lipopolysaccharide; SIRT1; Nrf2;
   kidney injury
ID MITOCHONDRIAL DYSFUNCTION; SEPSIS; INFLAMMATION; PATHOPHYSIOLOGY;
   NEPHROPATHY; ASSOCIATION; MANAGEMENT; HEART; VIEW
AB BackgroundSalidroside (SAL) is an anti-inflammatory, antioxidant, anticancer, neuroprotective, and renal protective active ingredient extracted from the Chinese herb. Rhodiola Rosea. However, the role of SAL in kidney injury has not yet been elucidated. The study investigates SAL's protective effect and mechanism in lipopolysaccharide (LPS)-induced kidney injury.MethodsMale C57BL/6 wild-type mice (6-8 weeks old) were intraperitoneally injected with 10 mg/kg LPS for 24 h and SAL (50 mg/kg) 2 h before the LPS injection. Biochemical and TUNNEL staining assay analyses were carried out to assess kidney injury. The Elisa assay analyzed the mRNA expression of NGAL and KIM-1. RT-qPCR and Western blotting measured the mRNA and protein expression of HO-1, NQO1, Beclin1, P62, SIRT1, Nrf2, and PNCA, respectively.ResultsOur study found that mice co-treated with SAL had significantly reduced blood urea nitrogen (BUN), serum creatinine (Scr), neutrophil gelatinase-associated lipocalin (NGAL), and kidney injury molecule-1 (KIM-1) levels in serum of LPS-induced mice. SAL cotreatment potentially decreased the apoptosis rate of kidney tissue and podocytes induced by LPS. SAL significantly reduced the content of malondialdehyde (MDA) and increased superoxide dismutase (SOD) in LPS-treated mice. Autophagy-related proteins Beclin-1 increased but decreased P62 protein expression by cotreatment of SAL in LPS-injected mice. SAL enhanced the Sirtuin 1 (SIRT1) and nuclear factor erythroid 2-related factor 2 (Nrf2) protein expression in LPS-induced kidney tissues.ConclusionOur results speculate that SAL protects against LPS-induced kidney injury through activation of the SIRT1/Nrf2 pathway.
C1 [Pan, Jiaying; Zhu, Jie; Li, Liang; Zhang, Tao; Xu, Zhenyu] Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Dept Emergency Med, 358 Datong Rd, Shanghai 200137, Peoples R China.
C3 Shanghai University of Traditional Chinese Medicine
RP Xu, ZY (corresponding author), Shanghai Univ Tradit Chinese Med, Peoples Hosp 7, Dept Emergency Med, 358 Datong Rd, Shanghai 200137, Peoples R China.
EM Xzy2062@163.com
FU Shanghai Pudong New Area Health System Key Specialty Construction
   Project [PWZzk2022-15]; Shanghai Health Commission Research Project
   [202040143]; Shanghai Seventh People's Hospital "Beidouxing" Talent
   Training Project [BDX2021-03]
FX The author(s) disclosed receipt of the following financial support for
   the research, authorship, and/or publication of this article: This study
   was supported by (1) Shanghai Pudong New Area Health System Key
   Specialty Construction Project (PWZzk2022-15); (2) Shanghai Health
   Commission Research Project (202040143); (3) Shanghai Seventh People's
   Hospital "Beidouxing" Talent Training Project (BDX2021-03).
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NR 36
TC 12
Z9 14
U1 2
U2 23
PU SAGE PUBLICATIONS LTD
PI LONDON
PA 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND
SN 0960-3271
EI 1477-0903
J9 HUM EXP TOXICOL
JI Hum. Exp. Toxicol.
PD APR
PY 2023
VL 42
AR 09603271231169520
DI 10.1177/09603271231169520
PG 9
WC Toxicology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Toxicology
GA E0VK8
UT WOS:000972815300001
PM 37078094
OA gold
DA 2026-05-27
ER

PT J
AU Wu, H
   Chen, W
   Zhao, F
   Zhou, QY
   Reinach, PS
   Deng, LL
   Ma, L
   Luo, SM
   Srinivasalu, N
   Pan, MZ
   Hu, Y
   Pei, XM
   Sun, J
   Ren, R
   Xiong, YH
   Zhou, ZL
   Zhang, S
   Tian, G
   Fang, JH
   Zhang, LN
   Lang, JD
   Wu, D
   Zeng, CQ
   Qu, J
   Zhou, XT
AF Wu, Hao
   Chen, Wei
   Zhao, Fei
   Zhou, Qingyi
   Reinach, Peter S.
   Deng, Lili
   Ma, Li
   Luo, Shumeng
   Srinivasalu, Nethrajeith
   Pan, Miaozhen
   Hu, Yang
   Pei, Xiaomeng
   Sun, Jing
   Ren, Ran
   Xiong, Yinghui
   Zhou, Zhonglou
   Zhang, Sen
   Tian, Geng
   Fang, Jianhuo
   Zhang, Lina
   Lang, Jidong
   Wu, Deng
   Zeng, Changqing
   Qu, Jia
   Zhou, Xiangtian
TI Scleral hypoxia is a target for myopia control
SO PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF
   AMERICA
LA English
DT Article
DE scleral hypoxia; myopia; scRNA-seq; HIF-1 alpha; scleral ECM remodeling
ID FORM-DEPRIVATION MYOPIA; GROWTH-FACTOR-BETA; TREE SHREW SCLERA; EYE
   GROWTH; GENE-EXPRESSION; CHOROIDAL THICKNESS; REFRACTIVE ERROR;
   GUINEA-PIGS; SALIDROSIDE; CELLS
AB Worldwide, myopia is the leading cause of visual impairment. It results from inappropriate extension of the ocular axis and concomitant declines in scleral strength and thickness caused by extracellular matrix (ECM) remodeling. However, the identities of the initiators and signaling pathways that induce scleral ECM remodeling in myopia are unknown. Here, we used single-cell RNA-sequencing to identify pathways activated in the sclera during myopia development. We found that the hypoxia-signaling, the eIF2-signaling, and mTOR-signaling pathways were activated in murine myopic sclera. Consistent with the role of hypoxic pathways in mouse model of myopia, nearly one third of human myopia risk genes from the genome-wide association study and linkage analyses interact with genes in the hypoxia-inducible factor-1 alpha (HIF-1 alpha)signaling pathway. Furthermore, experimental myopia selectively induced HIF-1 alpha up-regulation in the myopic sclera of both mice and guinea pigs. Additionally, hypoxia exposure (5% O-2) promoted myofibroblast transdifferentiation with down-regulation of type I collagen in human scleral fibroblasts. Importantly, the antihypoxia drugs salidroside and formononetin down-regulated HIF-la expression as well as the phosphorylation levels of eIF2 alpha and mTOR, slowing experimental myopia progression without affecting normal ocular growth in guinea pigs. Furthermore, eIF2 alpha phosphorylation inhibition suppressed experimental myopia, whereas mTOR phosphorylation induced myopia in normal mice. Collectively, these findings defined an essential role of hypoxia in scleral ECM remodeling and myopia development, suggesting a therapeutic approach to control myopia by ameliorating hypoxia.
C1 [Wu, Hao; Zhao, Fei; Zhou, Qingyi; Reinach, Peter S.; Ma, Li; Srinivasalu, Nethrajeith; Pan, Miaozhen; Hu, Yang; Pei, Xiaomeng; Sun, Jing; Ren, Ran; Xiong, Yinghui; Zhou, Zhonglou; Zhang, Sen; Qu, Jia; Zhou, Xiangtian] Wenzhou Med Univ, Sch Optometry & Ophthalmol, Wenzhou 325027, Zhejiang, Peoples R China.
   [Wu, Hao; Zhao, Fei; Zhou, Qingyi; Reinach, Peter S.; Ma, Li; Srinivasalu, Nethrajeith; Pan, Miaozhen; Hu, Yang; Pei, Xiaomeng; Sun, Jing; Ren, Ran; Xiong, Yinghui; Zhou, Zhonglou; Zhang, Sen; Qu, Jia; Zhou, Xiangtian] Wenzhou Med Univ, Eye Hosp, Wenzhou 325027, Zhejiang, Peoples R China.
   [Wu, Hao; Zhao, Fei; Zhou, Qingyi; Reinach, Peter S.; Ma, Li; Srinivasalu, Nethrajeith; Pan, Miaozhen; Hu, Yang; Pei, Xiaomeng; Sun, Jing; Ren, Ran; Xiong, Yinghui; Zhou, Zhonglou; Zhang, Sen; Qu, Jia; Zhou, Xiangtian] State Key Lab Optometry Ophthalmol & Vis Sci, Wenzhou 325027, Zhejiang, Peoples R China.
   [Wu, Hao; Zhao, Fei; Zhou, Qingyi; Reinach, Peter S.; Ma, Li; Srinivasalu, Nethrajeith; Pan, Miaozhen; Hu, Yang; Pei, Xiaomeng; Sun, Jing; Ren, Ran; Xiong, Yinghui; Zhou, Zhonglou; Zhang, Sen; Qu, Jia; Zhou, Xiangtian] Zhejiang Prov Key Lab Ophthalmol & Optometry, Wenzhou 325027, Zhejiang, Peoples R China.
   [Chen, Wei; Deng, Lili; Luo, Shumeng; Wu, Deng; Zeng, Changqing] Chinese Acad Sci, Beijing Inst Genom, Key Lab Genom & Precis Med, Beijing 100101, Peoples R China.
   [Deng, Lili; Luo, Shumeng; Wu, Deng; Zeng, Changqing] Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
   [Tian, Geng; Fang, Jianhuo; Zhang, Lina; Lang, Jidong] Tsinghua Univ, Genom & Synthet Biol Core Facil, Beijing 100084, Peoples R China.
C3 Wenzhou Medical University; Wenzhou Medical University; Chinese Academy
   of Sciences; Beijing Institute of Genomics, CAS; Chinese Academy of
   Sciences; University of Chinese Academy of Sciences, CAS; Tsinghua
   University
RP Qu, J; Zhou, XT (corresponding author), Wenzhou Med Univ, Sch Optometry & Ophthalmol, Wenzhou 325027, Zhejiang, Peoples R China.; Qu, J; Zhou, XT (corresponding author), Wenzhou Med Univ, Eye Hosp, Wenzhou 325027, Zhejiang, Peoples R China.; Qu, J; Zhou, XT (corresponding author), State Key Lab Optometry Ophthalmol & Vis Sci, Wenzhou 325027, Zhejiang, Peoples R China.; Qu, J; Zhou, XT (corresponding author), Zhejiang Prov Key Lab Ophthalmol & Optometry, Wenzhou 325027, Zhejiang, Peoples R China.; Zeng, CQ (corresponding author), Chinese Acad Sci, Beijing Inst Genom, Key Lab Genom & Precis Med, Beijing 100101, Peoples R China.; Zeng, CQ (corresponding author), Univ Chinese Acad Sci, Beijing 100049, Peoples R China.
EM czeng@big.ac.cn; jqu@wmu.edu.cn; zxt@mail.eye.ac.cn
RI Zhou, Qingyi/GRN-9679-2022; Reinach, Peter/AAI-3582-2021; zhou,
   xt/GWZ-9212-2022; Chen, Wei/IQW-3504-2023; Lang, Jidong/HQZ-2299-2023;
   Wu, Hao/KUD-5688-2024; Zhang, Sen/GXH-3145-2022; Wu, Deng/AAA-6506-2022
OI Lang, Jidong/0000-0003-1573-4114; Yang, Hu/0000-0003-3468-452X; 陈,
   伟/0000-0002-8087-7077; Wu, Hao/0000-0001-8448-5284; Luo,
   Shumeng/0000-0003-1080-6131; Zhang, Linhao/0000-0002-2631-0555; Zhang,
   Sen/0009-0004-1925-8383; Wu, Deng/0000-0003-3144-2007
FU National Natural Science Foundation of China [81670886, 81422007,
   81470659, 81170870, 3147119]; National Key Research and Development
   Program of China [2016YFC20160905200]; Natural Science Foundation of
   Zhejiang Province [LZ14H120001, LQ16H120006]; Zhejiang Provincial
   Program for the Cultivation of High-Level Innovative Health Talents;
   National Young Excellent Talents Support Program; Chinese Academy of
   Sciences Strategic Priority Research Program [XDB13020500]
FX The study was supported by National Natural Science Foundation of China
   Grants 81670886, 81422007, 81470659, 81170870, and 3147119; National Key
   Research and Development Program of China Grant 2016YFC20160905200;
   Natural Science Foundation of Zhejiang Province Grants LZ14H120001 and
   LQ16H120006; the Zhejiang Provincial Program for the Cultivation of
   High-Level Innovative Health Talents; the National Young Excellent
   Talents Support Program; and Chinese Academy of Sciences Strategic
   Priority Research Program (XDB13020500).
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NR 62
TC 420
Z9 496
U1 7
U2 141
PU NATL ACAD SCIENCES
PI WASHINGTON
PA 2101 CONSTITUTION AVE NW, WASHINGTON, DC 20418 USA
SN 0027-8424
J9 P NATL ACAD SCI USA
JI Proc. Natl. Acad. Sci. U. S. A.
PD JUL 24
PY 2018
VL 115
IS 30
BP E7091
EP E7100
DI 10.1073/pnas.1721443115
PG 10
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA GN9ZQ
UT WOS:000439574700016
PM 29987045
OA Green Submitted, Bronze
DA 2026-05-27
ER

PT J
AU El Maadawi, ZM
AF El Maadawi, Zeinab M.
TI Conditioned Medium Derived from Salidroside-Pretreated Mesenchymal Stem
   Cell Culture Ameliorates Mouse Lipopolysaccharide-Induced Cerebral
   Neuroinflammation-Histological and Immunohistochemical Study
SO INTERNATIONAL JOURNAL OF STEM CELLS
LA English
DT Article
ID FIBRILLARY ACIDIC PROTEIN; AMYLOID-BETA DEPOSITION; ALZHEIMERS-DISEASE;
   MEMORY DEFICITS; MICROGLIA; ASTROCYTES; GLUTAMATE; RESCUE; BRAIN; CORD
AB Background and Objectives: Neuroinflammation is involved in the pathogenesis of neurodegenerative disorders. Conditioned medium (CM) derived from bone marrow mesenchymal stem cells (MSCs) revealed substantial benefits due to its rich content of trophic factors. Salidroside (Sal), extracted from Rhodiola rosea, is known for its anti-inflammatory and neuroprotective effects. This study was designed to investigate the effect of Sal pretreated CM (CM-Sal) derived from bone marrow MSCs in lipopolysaccharide (LPS) induced neuroinflammation.
   Material and Methods: Fifty adult male mice were equally divided into 5 groups: Group I (Normal Control), Group II (LPS): single 0.8 mg/kg LPS intraperitoneally; Group III (LPS-DMEM), Group IV (LPS-CM) and Group V (LPS-CM-Sal): LPS was injected as group II followed, 24 hours later, by intranasal injection of 50 mu 1 of filtered serum -free Dulbecco's Modified Eagle's medium (DMEM), CM or CM-Sal, respectively, twice daily for 4 days. Animals were sacrificed at day 6 and paraffin cerebral sections were subjected to Hematoxylin and Eosin staining and immunohistochemistry with caspase 3 (apoptosis), glial fibrillary acidic protein GFAP (astrocytes) and CD68 (active microglia) followed by quantitative morphometric study.
   Results: Examination of LPS and LPS-DMEM groups revealed neuronal apoptosis with reactive astrogliosis and increased active microglia. LPS-CM and LPS-CM-Sal groups showed less apoptosis, less astrocytes and less active microglia. The regression in neuroinflammation was more evident in LPS-CM-Sal group and the difference was statistically significant compared to other groups.
   Conclusion: CM-Sal derived from MSCs culture elicited significant histopathological improvement in LPS induced neuroinflammation which could be used as new therapeutic modality.
C1 [El Maadawi, Zeinab M.] Cairo Univ, Dept Histol & Cell Biol, Fac Med, Cairo, Egypt.
C3 Egyptian Knowledge Bank (EKB); Cairo University
RP El Maadawi, ZM (corresponding author), Cairo Univ, Dept Histol & Cell Biol, Fac Med, Al Manial 11562, Egypt.
EM zeinab.elmaadawi@kasralainy.edu.eg
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NR 40
TC 7
Z9 7
U1 0
U2 14
PU KOREAN SOC STEM CELL RESEARCH
PI BANPO-DONG
PA CATHOLIC UNIV KOREA 505, INST BIOMEDICAL INDUSTRY, BANPO-DONG, SEOCHO-GU
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SN 2005-3606
EI 2005-5447
J9 INT J STEM CELLS
JI Int J. Stem Cells
PD MAY
PY 2017
VL 10
IS 1
BP 60
EP 68
DI 10.15283/ijsc16055
PG 9
WC Cell & Tissue Engineering; Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA EV8HJ
UT WOS:000402021000007
PM 28446004
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Gu, CJ
   Li, LW
   Huang, YF
   Qian, DF
   Liu, W
   Zhang, CL
   Luo, YJ
   Zhou, Z
   Kong, FQ
   Zhao, X
   Liu, H
   Gao, P
   Chen, J
   Yin, GY
AF Gu, Changjiang
   Li, Linwei
   Huang, Yifan
   Qian, Dingfei
   Liu, Wei
   Zhang, Chengliang
   Luo, Yongjun
   Zhou, Zheng
   Kong, Fanqi
   Zhao, Xuan
   Liu, Hao
   Gao, Peng
   Chen, Jian
   Yin, Guoyong
TI Salidroside Ameliorates Mitochondria-Dependent Neuronal Apoptosis after
   Spinal Cord Ischemia-Reperfusion Injury Partially through Inhibiting
   Oxidative Stress and Promoting Mitophagy
SO OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
LA English
DT Article
ID ACTIVATED PROTEIN-KINASE; ISCHEMIA/REPERFUSION INJURY;
   GLUCOSE-DEPRIVATION; HYPOXIA-ISCHEMIA; DISTINCT ROLES; OXYGEN;
   AUTOPHAGY; ANTIOXIDANT; UBIQUITIN; PATHWAY
AB Ischemia-reperfusion injury is the second most common injury of the spinal cord and has the risk of neurological dysfunction and paralysis, which can seriously affect patient quality of life. Salidroside (Sal) is an active ingredient extracted from Herba Cistanche with a variety of biological attributes such as antioxidant, antiapoptotic, and neuroprotective activities. Moreover, Sal has shown a protective effect in ischemia-reperfusion injury of the liver, heart, and brain, but its effect in ischemia-reperfusion injury of the spinal cord has not been elucidated. Here, we demonstrated for the first time that Sal pretreatment can significantly improve functional recovery in mice after spinal cord ischemia-reperfusion injury and significantly inhibit the apoptosis of neurons bothin vivoandin vitro. Neurons have a high metabolic rate, and consequently, mitochondria, as the main energy-supplying suborganelles, become the main injury site of spinal cord ischemia-reperfusion injury. Mitochondrial pathway-dependent neuronal apoptosis is increasingly confirmed by researchers; therefore, Sal's effect on mitochondria naturally attracted our attention. By means of a range of experiments bothin vivo andin vitro, we found that Sal can reduce reactive oxygen species production through antioxidant stress to reduce mitochondrial permeability and mitochondrial damage, and it can also enhance the PINK1-Parkin signaling pathway and promote mitophagy to eliminate damaged mitochondria. In conclusion, our results show that Sal is beneficial to the protection of spinal cord neurons after ischemia-reperfusion injury, mainly by reducing apoptosis associated with the mitochondrial-dependent pathway, among which Sal's antioxidant and autophagy-promoting properties play an important role.
C1 [Gu, Changjiang; Li, Linwei; Huang, Yifan; Qian, Dingfei; Liu, Wei; Luo, Yongjun; Zhou, Zheng; Kong, Fanqi; Zhao, Xuan; Liu, Hao; Gao, Peng; Chen, Jian; Yin, Guoyong] Nanjing Med Univ, Affiliated Hosp 1, Dept Orthoped, Nanjing, Jiangsu, Peoples R China.
   [Zhang, Chengliang] Peoples Hosp Shuyang City, Dept Orthoped, Shuyang, Jiangsu, Peoples R China.
C3 Nanjing Medical University
RP Chen, J; Yin, GY (corresponding author), Nanjing Med Univ, Affiliated Hosp 1, Dept Orthoped, Nanjing, Jiangsu, Peoples R China.
EM 1578679381@qq.com; 932282059@qq.com; hyf19941994@163.com;
   653860386@qq.com; lwnjmu@163.com; zhangcl7789@sina.com; lyjnjmu@163.com;
   zhouzhengright@qq.com; fanqi_kong@sina.com; zxc911@126.com;
   gnidam@foxmail.com; gaopeng9512@163.com; cbccj@sina.com;
   guoyong_yin@sina.com
RI Zhao, Xuan/JMR-2135-2023; Zhou, Zheng/MIT-1013-2025
FU National Natural Science Foundation of China [81772351, 81520108018,
   81472080, 81772352, 81401800]; Jiangsu Committee of Science and
   Technology-Social Development Plan [BE2017755]; Jiangsu Six Talents Peak
   [WSN-011]; Nanjing Committee of Science and Technology [201505005];
   Research Innovation Program for Academic Degree College Graduates of
   Jiangsu [KYLX16_1105]
FX We would like to express our sincere appreciation to our colleagues for
   their hard work in this study. This work was supported by grants from
   the National Natural Science Foundation of China (81772351, 81520108018,
   81472080, 81772352, and 81401800), the Jiangsu Committee of Science and
   Technology-Social Development Plan (BE2017755), the Jiangsu Six Talents
   Peak (WSN-011), the Nanjing Committee of Science and Technology
   (201505005), and the Research Innovation Program for Academic Degree
   College Graduates of Jiangsu (KYLX16_1105). We also thank International
   Science Editing (http://www.internationalscienceediting.com) for editing
   this manuscript.
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NR 80
TC 111
Z9 122
U1 0
U2 29
PU HINDAWI LTD
PI LONDON
PA ADAM HOUSE, 3RD FLR, 1 FITZROY SQ, LONDON, W1T 5HF, ENGLAND
SN 1942-0900
EI 1942-0994
J9 OXID MED CELL LONGEV
JI Oxidative Med. Cell. Longev.
PD JUL 23
PY 2020
VL 2020
AR 3549704
DI 10.1155/2020/3549704
PG 22
WC Cell Biology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cell Biology
GA MZ4YS
UT WOS:000559131700001
PM 32774670
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Li, HS
   Ying, H
   He, ZY
AF Li, Hong-Shan
   Ying, Hao
   He, Zhe-Yun
TI Salidroside and Curcumin Formula Prevents Liver Injury in Nonalcoholic
   Fatty Liver Disease in Rats
SO ANNALS OF HEPATOLOGY
LA English
DT Article
DE SC formula; Nonalcoholic fatty liver disease; Insulin resistance; Lipid
   peroxidation injury; AMPK signaling pathway
ID STEATOHEPATITIS; EPIDEMIOLOGY; ASSOCIATION; PREVALENCE; LIGHT
AB Introduction and aim. Salidroside and curcumin (SC) formula could alleviate lipid deposition in high fat diet-induced nonalcoholic fatty liver disease (NAFLD). However, the mechanisms are still unknown, and the magnitude of potential therapeutic benefit remains understudied. Material and methods. The rats were treated with high fat diet for 14 weeks to induce NAFLD. The experiment was divided into control, model (NAFLD), SC formula and rosiglitazone groups (n = 7 in each group). Hematoxylin-eosin (H&E) staining was applied to detect liver morphological changes. Biochemical, metabolic indices and inflammation factors in liver tissue and serum were detected. Additionally, the activities of related enzymes were detected by enzyme-linked immunosorbent assay. Results. In the established rat model, typical lipid deposition and liver steatosis were observed. Liver triglyceride, free fatty acids, sera alanine aminotransferase, aspartate aminotransferase, gamma-glutamyl transferase, fasting insulin, fasting blood glucose and homeostasis model assessment of insulin resistance were elevated in model group. Liver malondialdehyde was significantly elevated, while superoxide dismutase was significantly decreased in model group, compared with control. Moreover, tumor necrosis factor-alpha and Interleukin-1 were significantly produced in model group, compared with control. As a mechanism, high fat diet decreased tissue AMP-activated protein kinase (AMPK), phosphorylated AMPK, carnitine palmitoyltransferase 1 and increased inacetyl-CoA carboxylase (ACCase), phosphorylated ACCase. Importantly, these abnormal changes caused by high fat diet were reduced by SC formula administration. Conclusion. SC formula could ameliorate the injury caused by high fat diet. The effect was likely mediated via its influence on insulin resistance, lipid peroxidation injury and AMPK signaling pathway.
C1 [Li, Hong-Shan; Ying, Hao; He, Zhe-Yun] Ningbo 2 Hosp, Dept Hepatol, 175 Yongfeng Rd, Ningbo 315010, Zhejiang, Peoples R China.
   [Li, Hong-Shan] Ningbo Univ, Anim Lab Ctr, Med Sch, Ningbo, Zhejiang, Peoples R China.
C3 Ningbo University
RP Li, HS (corresponding author), Ningbo 2 Hosp, Dept Hepatol, 175 Yongfeng Rd, Ningbo 315010, Zhejiang, Peoples R China.
EM lihongshan_1982@126.com
FU National Natural Science Foundation of China [81873109]
FX This study was supported by National Natural Science Foundation of China
   (81873109).
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NR 27
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Z9 14
U1 1
U2 29
PU MEXICAN ASSOC HEPATOLOGY
PI MEXICO
PA PUNTE DE PIEDRA 150, COLONIA TORIELLO GUERRA, MEXICO, DF CP 14040,
   MEXICO
SN 1665-2681
J9 ANN HEPATOL
PD SEP-OCT
PY 2018
VL 17
IS 5
BP 769
EP 778
DI 10.5604/01.3001.0012.3135
PG 10
WC Gastroenterology & Hepatology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Gastroenterology & Hepatology
GA HO2MQ
UT WOS:000460749600005
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Beaulieu, F
   Cuerrier, A
   Filion, VJ
   Saleem, A
   Arnason, JT
AF Beaulieu, F.
   Cuerrier, A.
   Filion, V. J.
   Saleem, A.
   Arnason, J. T.
TI A gall mite, Aceria rhodiolae (Acari: Eriophyidae), altering the
   phytochemistry of a medicinal plant, Rhodiola rosea
   (Crassulaceae), in the Canadian Arctic
SO JOURNAL OF NATURAL HISTORY
LA English
DT Article
DE roseroot; phytophagous mites; Eriophyoidea; Nunavik; phytochemicals;
   flower galls
AB The eriophyid mite Aceria rhodiolae (G. Canestrini) is known to induce galls on the flowers and leaves of roseroot, Rhodiola rosea L., in subarctic and alpine regions of Europe. After discovering galls on the inflorescences of roseroot in Nunavik (Quebec), northeastern Canada, we examined the mites extracted from the galls and compared them with specimens of A.rhodiolae from Europe. Through morphological analyses, we demonstrate that the mites from galls in Nunavik are conspecific with A.rhodiolae from Europe. We then provide a detailed redescription of the mite species based on the morphology of adult females and males from Canada and Europe, using a combination of standard light microscopy, confocal microscopy and scanning electron microscopy. Because roseroot is well-known for its medicinal properties, we tested the hypothesis that roseroot galled by the mite had altered phytochemistry, by using salidroside and rosavins as indicators. Our results show a significant reduction of almost half in salidroside content (45.8%), but not in rosavins. Moreover, because the mite sometimes affects most or all of the inflorescence of R.rosea, it can considerably reduce the production of seeds. We also show that A.rhodiolae is widespread along the Ungava Bay (Nunavik), with 31.5% of 92 sites surveyed having at least a few to numerous plants galled. Given the importance of roseroot as a crop for Inuit communities and as medicinal products used by them and other Canadians, and also in view of the commonness of A.rhodiolae in the Canadian Arctic and its broad distribution in Europe, the impact of the mite and its relationship with roseroot should be examined further in Nunavik and elsewhere.
C1 [Beaulieu, F.] Agr & Agri Food Canada, Sci & Technol Branch, Canadian Natl Collect Insects Arachnids & Nematod, Ottawa, ON K1A 0C6, Canada.
   [Cuerrier, A.] Univ Montreal, Inst Rech Biol Vegetale, Jardin Bot Montreal, Montreal, PQ H1X 2B2, Canada.
   [Filion, V. J.; Saleem, A.; Arnason, J. T.] Univ Ottawa, Dept Biol, Ctr Adv Res Environm Genom, Ottawa, ON, Canada.
C3 Agriculture & Agri Food Canada; Universite de Montreal; University of
   Ottawa
RP Beaulieu, F (corresponding author), Agr & Agri Food Canada, Sci & Technol Branch, Canadian Natl Collect Insects Arachnids & Nematod, Ottawa, ON K1A 0C6, Canada.
EM frederic.beaulieu@agr.gc.ca
RI Arnason, John/GXM-3860-2022
FU Nunavik Bioscience (Makivik Corporation)
FX This paper benefited financially from Nunavik Bioscience ( Makivik
   Corporation).
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NR 87
TC 5
Z9 5
U1 2
U2 37
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 0022-2933
EI 1464-5262
J9 J NAT HIST
JI J. Nat. Hist.
PD MAY 26
PY 2016
VL 50
IS 19-20
BP 1237
EP 1263
DI 10.1080/00222933.2015.1103910
PG 27
WC Biodiversity Conservation; Ecology; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biodiversity & Conservation; Environmental Sciences & Ecology; Zoology
GA DI2AE
UT WOS:000373297300002
DA 2026-05-27
ER

PT J
AU Guo, F
   Zhang, XW
   You, C
   Zhang, CJ
   Li, FW
   Li, N
   Xia, YW
   Liu, MY
   Qiu, ZT
   Zheng, XL
   Ma, L
   Zhang, G
   Luo, LZ
   Cao, F
   Feng, YG
   Zhao, GR
   Zhang, W
   Li, SY
   Du, L
AF Guo, Fei
   Zhang, Xingwang
   You, Cai
   Zhang, Chengjie
   Li, Fengwei
   Li, Nan
   Xia, Yuwei
   Liu, Mingyu
   Qiu, Zetian
   Zheng, Xianliang
   Ma, Li
   Zhang, Gang
   Luo, Lianzhong
   Cao, Fei
   Feng, Yingang
   Zhao, Guang-Rong
   Zhang, Wei
   Li, Shengying
   Du, Lei
TI Diversification of phenolic glucosides by two UDP-glucosyltransferases
   featuring complementary regioselectivity
SO MICROBIAL CELL FACTORIES
LA English
DT Article
DE Phenolic glucosides; Biocatalysis; UDP-glucosyltransferases; Alkylphenol
   bio-oxidation
ID ENZYMATIC-SYNTHESIS; BIOSYNTHESIS; GLYCOSIDES; GLYCOSYLTRANSFERASE;
   RECONSTITUTION; ENDOPEPTIDASE; ANTIOXIDANT; SALIDROSIDE; METABOLISM;
   PRINCIPLE
AB Background Glucoside natural products have been showing great medicinal values and potentials. However, the production of glucosides by plant extraction, chemical synthesis, and traditional biotransformation is insufficient to meet the fast-growing pharmaceutical demands. Microbial synthetic biology offers promising strategies for synthesis and diversification of plant glycosides. Results In this study, the two efficient UDP-glucosyltransferases (UGTs) (UGT85A1 and RrUGT3) of plant origin, that are capable of recognizing phenolic aglycons, are characterized in vitro. The two UGTs show complementary regioselectivity towards the alcoholic and phenolic hydroxyl groups on phenolic substrates. By combining a developed alkylphenol bio-oxidation system and these UGTs, twenty-four phenolic glucosides are enzymatically synthesized from readily accessible alkylphenol substrates. Based on the bio-oxidation and glycosylation systems, a number of microbial cell factories are constructed and applied to biotransformation, giving rise to a variety of plant and plant-like O-glucosides. Remarkably, several unnatural O-glucosides prepared by the two UGTs demonstrate better prolyl endopeptidase inhibitory and/or anti-inflammatory activities than those of the clinically used glucosidic drugs including gastrodin, salidroside and helicid. Furthermore, the two UGTs are also able to catalyze the formation of N- and S-glucosidic bonds to produce N- and S-glucosides. Conclusions Two highly efficient UGTs, UGT85A1 and RrUGT3, with distinct regioselectivity were characterized in this study. A group of plant and plant-like glucosides were efficiently synthesized by cell-based biotransformation using a developed alkylphenol bio-oxidation system and these two UGTs. Many of the O-glucosides exhibited better PEP inhibitory or anti-inflammatory activities than plant-origin glucoside drugs, showing significant potentials for new glucosidic drug development.
C1 [Guo, Fei; Zhang, Xingwang; You, Cai; Zhang, Chengjie; Li, Fengwei; Liu, Mingyu; Ma, Li; Zhang, Wei; Li, Shengying; Du, Lei] Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Shandong, Peoples R China.
   [Du, Lei] Chinese Acad Agr Sci, Guangdong Lab Lingnan Modern Agr, Agr Genom Inst Shenzhen, Minist Agr,Genome Anal Lab,Shenzhen Branch, Shenzhen 518000, Peoples R China.
   [You, Cai; Feng, Yingang] Chinese Acad Sci, CAS Key Lab Biofuels, Qingdao Inst Bioenergy & Bioproc Technol, Shandong Prov Key Lab Synthet Biol, Qingdao 266101, Shandong, Peoples R China.
   [Qiu, Zetian; Zhao, Guang-Rong] Tianjin Univ, Sch Chem Engn & Technol, Frontier Sci Ctr Synthet Biol, Yaguan Rd 135, Tianjin 300350, Peoples R China.
   [Qiu, Zetian; Zhao, Guang-Rong] Tianjin Univ, Sch Chem Engn & Technol, Key Lab Syst Bioengn, Minist Educ, Yaguan Rd 135, Tianjin 300350, Peoples R China.
   [Xia, Yuwei] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao 266003, Shandong, Peoples R China.
   [Li, Nan] Tianjin Univ Sci & Technol, Coll Biotechnol, Tianjin 300457, Peoples R China.
   [Zhang, Gang; Luo, Lianzhong] Xiamen Med Coll, Fujian Univ & Coll Engn Res Ctr Marine Biopharmac, Xiamen 361023, Fujian, Peoples R China.
   [Cao, Fei] Hebei Univ, Coll Pharmaceut Sci, Baoding 071002, Peoples R China.
   [Li, Shengying] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Biol & Biotechnol, Qingdao 266237, Shandong, Peoples R China.
   [Zheng, Xianliang] Angel Yeast Co LTD, Ctr Biocatalysis & Enzyme Technol, Cheng Dong Ave, Yicha Ng 443003, Hubei, Peoples R China.
C3 Shandong University; Chinese Academy of Agricultural Sciences;
   Agriculture Genomes Institute at Shenzhen, CAAS; Guangdong Laboratory
   for Lingnan Modern Agriculture; Chinese Academy of Sciences; Qingdao
   Institute of Bioenergy & Bioprocess Technology, CAS; Tianjin University;
   Tianjin University; Ocean University of China; Tianjin University of
   Science & Technology; Xiamen Medical College; Hebei University; Laoshan
   Laboratory
RP Du, L (corresponding author), Shandong Univ, State Key Lab Microbial Technol, Qingdao 266237, Shandong, Peoples R China.; Du, L (corresponding author), Chinese Acad Agr Sci, Guangdong Lab Lingnan Modern Agr, Agr Genom Inst Shenzhen, Minist Agr,Genome Anal Lab,Shenzhen Branch, Shenzhen 518000, Peoples R China.
EM lei.du@sdu.edu.cn
RI ; Luo, Lianzhong/AAD-9311-2022; Feng, Yingang/B-6304-2008
OI Zheng, Xianliang/0000-0003-0643-7871; Feng, Yingang/0000-0002-0879-1316
FU National Key Research and Development Program of China [2021YFA0911500];
   National Natural Science Foundation of China [32000039, 32071266,
   32025001, 82022066, U2106227, 32170088]; Shandong Provincial Natural
   Science Foundation [ZR2020ZD23, ZR2019BB024, ZR2019ZD20]; Open Projects
   Fund of SKLMT [M2021-04]
FX This study was supported by the National Key Research and Development
   Program of China (2021YFA0911500), the National Natural Science
   Foundation of China (32170088), Shandong Provincial Natural Science
   Foundation (ZR2020ZD23, ZR2019BB024 and ZR2019ZD20), the National
   Natural Science Foundation of China (32000039, 32071266, 32025001,
   82022066 and U2106227), and the Open Projects Fund of SKLMT (M2021-04).
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NR 69
TC 18
Z9 18
U1 2
U2 53
PU BMC
PI LONDON
PA CAMPUS, 4 CRINAN ST, LONDON N1 9XW, ENGLAND
EI 1475-2859
J9 MICROB CELL FACT
JI Microb. Cell. Fact.
PD OCT 10
PY 2022
VL 21
IS 1
AR 208
DI 10.1186/s12934-022-01935-w
PG 14
WC Biotechnology & Applied Microbiology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biotechnology & Applied Microbiology
GA 5E6YR
UT WOS:000865769500002
PM 36217200
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Liu, WH
   Li, SQ
   Tao, FF
   Wu, LC
   Luo, F
   Sun, TF
   Zhao, JH
   Li, JF
   Li, CY
AF Liu, Wenhong
   Li, Shiqing
   Tao, Fangfang
   Wu, Lichao
   Luo, Fei
   Sun, Tengfei
   Zhao, Junhui
   Li, Junfeng
   Li, Changyu
TI The Mechanism of Jieduquyuziyin Prescription in the Treatment of
   Systemic Lupus Erythematosus via Nek7-NLRP3 Signaling Pathway
SO JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
LA English
DT Article
DE Jieduquyuziyin Prescription; Systemic Lupus Erythematosus; Inflammation;
   Nek7-NLRP3; Material Basis
ID ACTIVATION
AB This study aimed to investigate the mechanism and partial material basis of Jieduquyuziyin prescription (JQZP) reduces systemic lupus erythematosus (SLE) inflammation via regulating Nek7-NLRP3 signaling pathway. The therapeutic effect of JQZP was evaluated by MRL/lpr SLE mice model in vivo and Lipopolysaccharide (LPS)-induced RAW264.7 macrophage inflammation model in vitro. The partial material basis of JQZP was analyzed by network pharmacology, molecular docking and HPLC. The effect of JQZP on inhibiting the Nek7-NLRP3 signaling pathway and the underlying molecular mechanism were investigated by ELISA, RT-qPCR and Western blot. In vivo experiments showed that JQZP could ameliorate renal histopathological changes, decreaseIP 8.46spleen247.10index, 24On:h Mo,urine 12andDecurine2022creatinine06:15 28(UCR) concentration, and increase urinary microalbumin (ALB) concentratin and microalbumi/creatinine ratio (ACR) in MRL/lpr mice. In addition, JQZP Copyright: Amercan Scientific Pub ishers down-regulated the levels of pro-inflammatory cytokines IL-18 and IL-1 beta both in vivo and in vitro. Network pharmacology Delivered by Ingenta and HPLC analysis showed that salidroside, luteolin and apigenin in JQZP-medicated serum were partial main active ingredients, and molecular docking showed that all three main active ingredients could bind to Nek7, NLRP3 and ASC well. Western blot further confirmed that JQZP, JQZP-medicated serum and active monomer ingredients could regulate the expression of Nek7, NLRP3, and ASC in Nek7-NLRP3 signaling pathway. JQZP has a certain effect on improving excessive inflammation of SLE, and the mechanism of action may be related to the inhibition of Nek7-NLRP3 signaling pathway. Salidroside, luteolin and apigenin may be partial material basis for exerting this effect.
C1 [Liu, Wenhong; Li, Shiqing; Li, Changyu] Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Peoples R China.
   [Liu, Wenhong; Tao, Fangfang; Wu, Lichao; Luo, Fei; Sun, Tengfei; Zhao, Junhui; Li, Junfeng] Zhejiang Chinese Med Univ, Sch Basic Med Sci, Hangzhou 310053, Peoples R China.
   [Li, Changyu] Zhejiang Chinese Med Univ, Acad Chinese Med Sci, Hangzhou 310053, Peoples R China.
C3 Zhejiang Chinese Medical University; Zhejiang Chinese Medical
   University; Zhejiang Chinese Medical University
RP Li, CY (corresponding author), Zhejiang Chinese Med Univ, Sch Pharmaceut Sci, Hangzhou 310053, Peoples R China.; Li, JF (corresponding author), Zhejiang Chinese Med Univ, Sch Basic Med Sci, Hangzhou 310053, Peoples R China.; Li, CY (corresponding author), Zhejiang Chinese Med Univ, Acad Chinese Med Sci, Hangzhou 310053, Peoples R China.
EM lwh@zcmu.edu.cn; lm159@sina.com
RI Tao, Fangfang/E-5909-2010; Sun, Tengfei/GXM-5270-2022
FU National Natural Science Foundation of China [82074304]; Zhejiang
   Province Public Welfare Technology Application Research Project
   [LGN20H280002]; Zhejiang Traditional Chinese Medicine Science and
   Technology Project [2020ZA033]; Scientific Research Fund Project of
   Zhejiang Chinese Medical University [2020ZG06]
FX This work was supported by National Natural Science Foundation of China
   (No. 82074304), Zhejiang Province Public Welfare Technology Application
   Research Project (No. LGN20H280002), Zhejiang Traditional Chinese
   Medicine Science and Technology Project (No. 2020ZA033), and Scientific
   Research Fund Project of Zhejiang Chinese Medical University ( No.
   2020ZG06). We thank Li Xie and Weilan Wang (Bioultrastructure Analysis
   Laboratory, Analysis Center of Agrobiology and Environ-mental Sciences,
   Zhejiang University) for scanning electron microscope (SEM) support.
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NR 21
TC 0
Z9 1
U1 0
U2 19
PU AMER SCIENTIFIC PUBLISHERS
PI VALENCIA
PA 26650 THE OLD RD, STE 208, VALENCIA, CA 91381-0751 USA
SN 1550-7033
EI 1550-7041
J9 J BIOMED NANOTECHNOL
JI J. Biomed. Nanotechnol.
PD AUG
PY 2022
VL 18
IS 8
BP 1782
EP 1792
DI 10.1166/jbn.2022.3395
PG 11
WC Nanoscience & Nanotechnology; Materials Science, Biomaterials
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics; Materials Science
GA 8H1MJ
UT WOS:000920800700001
DA 2026-05-27
ER

PT J
AU Kalia, S
   Bharti, VK
   Giri, A
   Vivek, P
   Kumar, B
   Udayabanu, M
AF Kalia, Sahil
   Bharti, Vijay Kumar
   Giri, Arup
   Vivek, Prince
   Kumar, Bhuvnesh
   Udayabanu, Malairaman
TI Effect of hydro-alcoholic extract of Rhodiola imbricata on growth
   performance, immunomodulation, antioxidant level and blood biochemical
   parameters in broiler chickens at high altitude cold desert
SO INDIAN JOURNAL OF ANIMAL SCIENCES
LA English
DT Article
DE Broiler; Growth; High altitude; Immune responses; Rhodiola imbricata
ID OXIDATIVE-STRESS; MEDICINAL-PLANTS; SALIDROSIDE; ACTIVATION; EDGEW;
   INDIA
AB Extremes of climate and hypobaric hypoxia cause poor growth performance in broiler chickens at high altitude. The current study was designed to investigate the effect of hydro-alcoholic extract of Rhodiola imbricata on antioxidant, cytokines, blood biochemical and growth performance of broilers at high altitude (3500 m). For in-vivo study, one day-old broiler chicks of average initial body weight 36.40+/-0.42 g were randomly assigned to seven groups in three replicates (10 chicks in each replicate) as per completely randomized design. Experimental groups included control (fed basal diet), and treatment T1, T2, T3, T4, T5, and T6 which received hydro-alcoholic extract of Rhodiola imbricata in drinking water @ 100, 150, 200, 300, 400, and 800 mg/kg body weight of chicken respectively, along with basal diet. Blood samples were collected at 0, 21st, and 42nd day. HPLC analysis of extract revealed the presence of salidroside and p-tyrosol. As a result of this study, birds in T5 group had significantly higher body weight as compared to other groups. Furthermore, they had significantly higher total antioxidant capacity, free radical scavenging activity, interleukin-2, total protein, globulin, HDL level and lower malondialdehyde, interleukin-6, cholesterol, triglyceride, LDL, glucose, A/G, ALT, AST level as compared to control group. Our results suggest that, Rhodiola imbricata extract @ 400 mg/kg body weight of chicken, exhibited beneficial effect on growth performance and therefore, can be used as a phytogenic feed additive for broiler chickens.
C1 [Kalia, Sahil; Giri, Arup; Vivek, Prince; Kumar, Bhuvnesh; Udayabanu, Malairaman] DRDO, DIHAR, Leh Ladakh 194101, Jammu & Kashmir, India.
   [Bharti, Vijay Kumar] DRDO, DIHAR, Div Anim Sci, Leh Ladakh 194101, Jammu & Kashmir, India.
   [Kumar, Bhuvnesh] Def Inst Physiol & Allied Sci, Delhi, India.
   [Udayabanu, Malairaman] Jaypee Univ Informat & Technol, Waknaghat, Solan, India.
C3 Defence Research & Development Organisation (DRDO); Defence Institute of
   High Altitude Research (DIHAR); Defence Research & Development
   Organisation (DRDO); Defence Institute of High Altitude Research
   (DIHAR); Defence Research & Development Organisation (DRDO); Defence
   Institute of Physiology & Allied Sciences (DIPAS); Jaypee University of
   Information Technology
RP Kalia, S (corresponding author), DRDO, DIHAR, Leh Ladakh 194101, Jammu & Kashmir, India.
EM sahilkalia87@gmail.com; vijaykbharti@rediffmail.com;
   arupsatadal@gmail.com; prince.v68@gmail.com;
   bhuvnesh_5aug@rediffmail.com; m_udayabanu@rediffmail.com
RI Bharti, DVM, MVSc, FNESA, Assoc.Fellow NAVS, Vijay K/P-2015-2018;
   Malairaman, Udayabanu/K-6665-2012; Bharti, Vijay/P-2015-2018; kalia,
   sahil/J-3361-2019; Giri, Arup/AAE-5335-2022
OI Bharti, DVM, MVSc, FNESA, Assoc.Fellow NAVS, Vijay
   K/0000-0001-6072-8704; kalia, sahil/0000-0001-5774-7138; Giri,
   Arup/0000-0002-2313-3581
FU Defence Research and Development Organisation (DRDO), Ministry of
   Defence, Government of India
FX The present study was fully supported by Defence Research and
   Development Organisation (DRDO), Ministry of Defence, Government of
   India. Authors would like to thank all the staff of DIHAR poultry
   division for the care of birds and for their assistance during the blood
   sampling.
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TC 4
Z9 4
U1 1
U2 10
PU INDIAN COUNC AGRICULTURAL RES
PI NEW DELHI
PA KAB-1, NEW DELHI 110012, INDIA
SN 0367-8318
J9 INDIAN J ANIM SCI
JI Indian J. Anim. Sci.
PD OCT
PY 2017
VL 87
IS 10
BP 1200
EP 1206
PG 7
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA FO7CV
UT WOS:000417029500005
DA 2026-05-27
ER

PT J
AU Cui, JL
   Guo, TT
   Ren, ZX
   Zhang, NS
   Wang, ML
AF Cui, Jin-Long
   Guo, Ting-Ting
   Ren, Zhen-Xing
   Zhang, Na-Sha
   Wang, Meng-Liang
TI Diversity and Antioxidant Activity of Culturable Endophytic Fungi from
   Alpine Plants of Rhodiola crenulata, R-angusta, and
   R-sachalinensis
SO PLOS ONE
LA English
DT Article
ID PESTALOTIOPSIS-MICROSPORA; SALIDROSIDE; L.; CELLS; ROSEA; IMBRICATA;
   EXTRACTS; RESOURCE; TYROSOL; TAXOL
AB Rhodiola spp. are rare and endangered alpine plants widely used as medicines and food additives by many civilizations since ancient times. Their main effective ingredients (such as salidroside and p-tyrosol) are praised to exhibit pharmacologic effects on high-altitude sickness and possess anti-aging and other adaptogenic capacities based on their antioxidant properties. In this study, 347 endophytic fungi were isolated from R. crenulata, R. angusta, and R. sachalinensis, and the molecular diversity and antioxidant activities of these fungi were investigated for the first time. These fungi were categorized into 180 morphotypes based on cultural characteristics, and their rRNA gene ITS sequences were analyzed by BLAST search in the GenBank database. Except for 12 unidentified fungi (6.67%), all others were affiliated to at least 57 genera in 20 orders of four phyla, namely, Ascomycota (88.89%), Basidiomycota (2.78%), Zygomycota (1.11%), and Glomeromycota (0.56%), which exhibited high abundance and diversity. Antioxidant assay showed that the DPPH radical-scavenging rates of 114 isolates (63.33%) were >50%, and those of five isolates (Rct45, Rct63, Rct64, Rac76, and Rsc57) were >90%. The EC50 values of five antioxidant assays suggested significant potential of these fungi on scavenging DPPH center dot, O-2-center dot, and OH center dot radicals, as well as scavenging nitrite and chelating Fe2+, which showed preference and selection between endophytic fungi and their hosts. Further research also provided the first evidence that Rac12 could produce salidrosides and p-tyrosol. Results suggested that versatile endophytic fungi associated with Rhodiola known as antioxidants could be exploited as potential sources of novel antioxidant products.
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   [Guo, Ting-Ting; Zhang, Na-Sha] Shanxi Univ, Inst Biotechnol, Taiyuan 030006, Shanxi Province, Peoples R China.
C3 Shanxi University; Shanxi University
RP Wang, ML (corresponding author), Shanxi Univ, Inst Appl Chem, Taiyuan 030006, Shanxi Province, Peoples R China.
EM cjl717@sxu.edu.cn
RI Ren, Zhenxing/A-2260-2017
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NR 55
TC 95
Z9 118
U1 4
U2 23
PU PUBLIC LIBRARY SCIENCE
PI SAN FRANCISCO
PA 1160 BATTERY STREET, STE 100, SAN FRANCISCO, CA 94111 USA
SN 1932-6203
J9 PLOS ONE
JI PLoS One
PD MAR 13
PY 2015
VL 10
IS 3
AR e0118204
DI 10.1371/journal.pone.0118204
PG 16
WC Multidisciplinary Sciences
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Science & Technology - Other Topics
GA CD7NO
UT WOS:000351277500021
PM 25768014
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Cadamuro, F
   Ferrario, M
   Akbari, R
   Antonini, C
   Nicotra, F
   Russo, L
AF Cadamuro, Francesca
   Ferrario, Matteo
   Akbari, Raziyeh
   Antonini, Carlo
   Nicotra, Francesco
   Russo, Laura
TI Tyrosine glucosylation of collagen films exploiting Horseradish
   Peroxidase (HRP)
SO CARBOHYDRATE RESEARCH
LA English
DT Article
DE Biomaterials glycosylation; Collagen; HRP; Glycosignature
ID OXIDATION; SURFACES; GLYCANS
AB The development of human tissue models for regenerative medicine and animal-free drug screening requires glycosylated biomaterials such as collagen. An easy and fast biomaterial glycosylation method exploiting Horseradish Peroxidase (HRP) phenol coupling reaction is proposed. The protocol is adaptable to any polymer functionalized with phenol residues or tyrosine containing proteins. As a model the tyrosine residues on collagen films were functionalized with salidroside, a natural beta-glucoside with a phenol in the aglycone. Scanning Electron Microscope (SEM) and contact angle analysis revealed the influence of glycosylation on the sample's morphology and wettability. Preliminary biological evaluation showed the cytocompatibility of the glucosylated collagen films.
C1 [Cadamuro, Francesca; Ferrario, Matteo; Nicotra, Francesco; Russo, Laura] Univ Milano Bicocca, Sch Med & Surg, I-20854 Vedano Al Lambro, Italy.
   [Akbari, Raziyeh; Antonini, Carlo] Univ Milano Bicocca, Dept Mat Sci, I-20126 Milan, Italy.
   [Russo, Laura] Natl Univ Ireland Galway, SFI Res Ctr Med Devices, CURAM, Galway H91 TK33, Ireland.
   [Russo, Laura] Sch Med & Surg, Via Raoul Follereau 3, I-20854 Vedano Al Lambro, MB, Italy.
C3 University of Milano-Bicocca; University of Milano-Bicocca
RP Russo, L (corresponding author), Sch Med & Surg, Via Raoul Follereau 3, I-20854 Vedano Al Lambro, MB, Italy.
EM francesca.cadamuro@unimib.it; m.ferrario@campus.unimib.it;
   raziyeh.akbari@unimib.it; carlo.antonini@unimib.it;
   francesco.nicotra@unimib.it; laura.russo@unimib.it
RI Russo, Laura/I-3237-2014; Nicotra, Francesco/AAM-3513-2020; Antonini,
   Carlo/A-4112-2015; Akbari, Raziyeh/ABM-7634-2022
FU COST Action [CUP: B53C22006670001]; Italian Ministry of Health
   [RF-2016-02362946]; National Plan for NRRP Complementary Investments; 
   [CA18132]
FX The authors acknowledge Dr. Paolo Gentile for SEM analysis. This work
   was funded by: COST Action CA18132-Functional Glyconanomaterials for the
   Development of Diagnostics and Targeted Therapeutic Probes
   (GLYCONanoPROBES) ; Italian Ministry of Health (Grant No.
   RF-2016-02362946) ; the National Plan for NRRP Complementary Investments
   in the call for the funding of research initiatives for technologies and
   innovative trajectories in the health and care sectors-project AdvaNced
   Technologies for Human-centrEd Medicine (ANTHEM) CUP: B53C22006670001.
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NR 27
TC 3
Z9 3
U1 0
U2 11
PU ELSEVIER SCI LTD
PI London
PA 125 London Wall, London, ENGLAND
SN 0008-6215
EI 1873-426X
J9 CARBOHYD RES
JI Carbohydr. Res.
PD NOV
PY 2023
VL 533
AR 108938
DI 10.1016/j.carres.2023.108938
PG 7
WC Biochemistry & Molecular Biology; Chemistry, Applied; Chemistry, Organic
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA EV0Z6
UT WOS:001141603700001
PM 37713734
OA Green Submitted, hybrid
DA 2026-05-27
ER

PT J
AU Li, J
   Guan, XK
   Liu, RX
AF Li Jie
   Guan Xuan-ke
   Liu Ru-xiu
TI Role of Chinese Herbal Medicines in Regulation of Energy Metabolism in
   Treating Cardiovascular Diseases
SO CHINESE JOURNAL OF INTEGRATIVE MEDICINE
LA English
DT Review
DE biologically active ingredient; Chinese herbal medicine; cardiovascular
   disease; ischemic heart disease; heart failure
ID ISCHEMIA-REPERFUSION INJURY; IMPROVES CARDIAC-FUNCTION;
   TRICARBOXYLIC-ACID CYCLE; ASTRAGALOSIDE IV; MYOCARDIAL-INFARCTION;
   SALVIA-MILTIORRHIZA; OXIDATIVE STRESS; SALIDROSIDE; RUTAECARPINE;
   APOPTOSIS
AB Recently, studying myocardial energy metabolism pathways or improving myocardial metabolism through drugs is another effective strategy for treating ischemic heart disease. Many active components of Chinese herbal medicines (CHMs) have been found to modulate energy metabolism in myocardial cells, cerebral vascular cells, endothelial cells and tumour cells. This paper reviews the advances in studies on the active components of CHMs that modulating energy metabolism in treating cardiovascular diseases over the past five years.
C1 [Li Jie; Guan Xuan-ke; Liu Ru-xiu] Chinese Acad Chinese Med Sci, Guanganmen Hosp, Dept Cardiol, Beijing 100053, Peoples R China.
C3 Guang'anmen Hospital, CACMS
RP Liu, RX (corresponding author), Chinese Acad Chinese Med Sci, Guanganmen Hosp, Dept Cardiol, Beijing 100053, Peoples R China.
EM liuruxiu1@163.com
FU National Natural Science Foundation of China [81873293]
FX Supported by the National Natural Science Foundation of China (No.
   81873293)
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NR 64
TC 8
Z9 10
U1 0
U2 43
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 1672-0415
EI 1993-0402
J9 CHIN J INTEGR MED
JI Chin. J. Integr. Med.
PD APR
PY 2019
VL 25
IS 4
BP 307
EP 315
DI 10.1007/s11655-018-2943-5
PG 9
WC Integrative & Complementary Medicine
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Integrative & Complementary Medicine
GA IF2FV
UT WOS:000472893900012
PM 31236891
DA 2026-05-27
ER

PT J
AU Li, JX
   Zhao, CC
   Zu, K
   Fan, ZP
   Qi, DD
   Kong, FR
   Liu, ML
   Gao, J
   Li, EZ
   Gao, WW
   Du, XL
   Song, YX
   Liu, GW
   Li, XW
   Feng, HH
   Lei, L
AF Li, Jinxia
   Zhao, Chenchen
   Zu, Kun
   Fan, Zipei
   Qi, Dandan
   Kong, Fanrong
   Liu, Menglin
   Gao, Jie
   Li, Enzhu
   Gao, Wenwen
   Du, Xiliang
   Song, Yuxiang
   Liu, Guowen
   Li, Xinwei
   Feng, Haihua
   Lei, Lin
TI Salidroside protects bovine hepatocytes against fatty acid-induced lipid
   accumulation and inflammation by activating AMPK/SIRT1 pathway
SO JOURNAL OF DAIRY SCIENCE
LA English
DT Article
DE salidroside; bovine hepatocytes; AMPK/ SIRT1 pathway; lipid
   accumulation; inflammation
ID NF-KAPPA-B; DAIRY-COWS; HEPATIC STEATOSIS; SIRT1; LIVER; METABOLISM;
   INSULIN; AMPK; LIPOMOBILIZATION
AB Fat mobilization and elevated circulating levels of nonesterified fatty acids (NEFA) resulting from severe negative energy balance (NEB) are the major causes of hepatic lipid accumulation and inflammation in dairy cows during the transition period. However, there is a lack of promising therapeutic agents to control NEFAinduced lipotoxicity in the liver of dairy cows. Thus, the objective of this study was to investigate the effects of salidroside (Sal), the principal bioactive component of Rhodiola, on NEFA-induced lipotoxicity in bovine hepatocytes, as well as the underlying molecular mechanisms. Bovine hepatocytes were isolated from 5 healthy Holstein female newborn calves (1 d of age, 30-40 kg, fasting) and treated with NEFA (1.2 mM), Sal (0, 5, 25, 50, 100, or 200 mu M), or both for 12 h. To elucidate the role of the AMP-activated protein kinase (AMPK)/silent information regulator 1 (SIRT1) signaling axis, hepatocytes were additionally treated with inhibitors against AMPK or SIRT1. The results showed that Sal treatment significantly alleviated NEFA-induced increases in triacylglycerol (TAG) content, protein abundance of sterol regulatory element-binding protein 1c (SREBP-1c) and mRNA levels of SREBP1 and acetyl-CoA carboxylase 1 (ACACA). Furthermore, Sal alleviated the downregulation of peroxisome proliferator-activated receptor alpha (PPARA) protein abundance and mRNA levels of PPARA and carnitine palmitoyltransferase 1A (CPT1A). In addition, Sal treatment markedly decreased NEFA-induced phosphorylation levels of nuclear factor kappa B (NF-kappa B) and its inhibitor (I kappa B)alpha, as well as mRNA levels of IL1B, IL6, and tumor necrosis factor alpha (TNFA). These results demonstrate that Sal possesses the capacity to effectively alleviate the lipotoxic effects provoked by NEFA in bovine hepatocytes. Moreover, Sal treatment prevented the inhibition of AMPK/SIRT1 signaling pathway in NEFA-challenged bovine hepatocytes. Importantly, the blockage of AMPK/SIRT1 abrogated the protective effects of Sal against NEFA-induced lipid accumulation and inflammation, as evidenced by increased TAG content, elevated protein abundance of SREBP-1c and phosphorylation levels of NF-kappa B and I kappa B alpha, along with upregulated mRNA levels of SREBP1, ACACA, IL1B, IL6, and TNFA. Concurrently, PPARA protein expression and the gene expression of PPARA and CPT1A were decreased. In conclusion, these findings suggest that Sal ameliorates lipid accumulation and inflammation by activating AMPK/SIRT1 pathway in bovine hepatocytes, which may represent a promising therapeutic strategy to mitigate the hepatic lipotoxicity of elevated NEFA levels during transition periods in dairy cows.
C1 [Li, Jinxia; Zhao, Chenchen; Zu, Kun; Qi, Dandan; Kong, Fanrong; Liu, Menglin; Gao, Jie; Li, Enzhu; Gao, Wenwen; Du, Xiliang; Song, Yuxiang; Liu, Guowen; Li, Xinwei; Feng, Haihua; Lei, Lin] Jilin Univ, Coll Vet Med, State Key Lab Zoonot Dis, Key Lab Zoonosis Res,Minist Educ, 5333 Xian Rd, Changchun 130062, Jilin, Peoples R China.
   [Fan, Zipei] Jilin Univ, Sch Artificial Intelligence, Changchun 130012, Jilin, Peoples R China.
C3 Jilin University; Jilin University
RP Feng, HH; Lei, L (corresponding author), Jilin Univ, Coll Vet Med, State Key Lab Zoonot Dis, Key Lab Zoonosis Res,Minist Educ, 5333 Xian Rd, Changchun 130062, Jilin, Peoples R China.
EM fhh70@163.com; jiluleilin@126.com
RI LEI, LIN/JAN-6074-2023; Song, Yuxiang/F-1446-2019; 子沛, 范/AAJ-2988-2020;
   GAO, WENWEN/ABG-5988-2020
OI LEI, LIN/0000-0001-5740-1508; Qi, Dandan/0009-0007-6079-6492; 
FU National Key Re-search and Development Programs of China (Beijing,
   China) [2023YFE0116900]; National Natural Science Foundation of China
   (Beijing, China) [32273059, 32302943]; Jilin University Ethics Committee
   on the Use and Care of Animals (Changchun, China) [SY202410016]
FX This work was supported by the National Key Re-search and Development
   Programs of China (Beijing, China; grant no. 2023YFE0116900) and
   National Natural Science Foundation of China (Beijing, China; grant no.
   32273059 and 32302943) . Supplemental material for this article is
   available at https://doi.org/10.6084/m9.figshare .29484839. The animal
   experiment was conducted in ac-cordance with the guidelines of the Jilin
   University Ethics Committee on the Use and Care of Animals (Changchun,
   China; No. SY202410016) . The authors have not stated any conflicts of
   interest.
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NR 53
TC 4
Z9 4
U1 10
U2 13
PU ELSEVIER SCIENCE INC
PI NEW YORK
PA STE 800, 230 PARK AVE, NEW YORK, NY 10169 USA
SN 0022-0302
EI 1525-3198
J9 J DAIRY SCI
JI J. Dairy Sci.
PD SEP
PY 2025
VL 108
IS 9
BP 10136
EP 10150
DI 10.3168/jds.2024-26083
EA AUG 2025
PG 15
WC Agriculture, Dairy & Animal Science; Food Science & Technology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Food Science & Technology
GA 8AL1U
UT WOS:001583991600031
PM 40645487
OA gold
DA 2026-05-27
ER

PT J
AU Park, JS
   Kwon, E
   Kim, YS
   Kim, SM
   Kim, DS
   Jang, JJ
   Yun, JW
   Kang, BC
AF Park, Jin-Sung
   Kwon, Euna
   Kim, Yun-Soon
   Kim, Sang-Moo
   Kim, Dae-Sun
   Jang, Ja-June
   Yun, Jun-Won
   Kang, Byeong-Cheol
TI Safety Assessment of Acer tegmentosum Maxim. Water Extract:
   General Toxicity Studies in Sprague-Dawley Rats and Beagle Dogs With
   Re-evaluation of Genotoxic Potentials
SO FRONTIERS IN PHARMACOLOGY
LA English
DT Article
DE Acer tegmentosum Maxim; salidroside; repeated oral toxicity; rodents;
   beagle dogs; genotoxicity
ID IN-VIVO; PHENOLIC CONSTITUENTS; INDUCED CYTOTOXICITY; SALIDROSIDE;
   VITRO; MECHANISMS
AB Acer tegmentosum Maxim., commonly known as Manchurian stripe maple, is a deciduous tree belonging to the family of Aceraceae and has been traditionally used in folk medicine for its remedial effects in liver diseases and traumatic bleedings. With a growing body of experimental evidence for its pharmacological efficacies, such as neuroprotective, hepatoprotective, antioxidant, and anti-inflammatory activities, A. tegmentosum has gradually gained popularity as a health supplement and functional food. However, the large part of essential toxicity information still remained lacking despite the possibility of mutagenic potentials as previously suggested, posing safety concerns for human consumption. In this study, we evaluated 90-day repeated oral toxicity of A. tegmentosum Maxim. water extract (ATWE) in SD rats with acute toxicity assessment in beagle dogs, and reevaluated genotoxicity using a combination of in vitro and in vivo assays. During the oral study period, ATWE did not cause toxicity-related clinical signs and mortality in rodents without adverse effects observed in the analysis of hematology, serum biochemistry, and histopathology, establishing > 5,000 mg/kg BW as the NOAEL. In addition, doses up to 5,000 mg/kg BW did not cause acute toxicity in beagle dogs. When assessed for genotoxicity using bacterial reverse mutation, chromosome aberration, and micronucleus formation, ATWE showed lack of mutagenicity and clastogenicity. These results demonstrated that AWTE was safe in the present preclinical study for systemic toxicity and genotoxicity at the tested doses, providing a guideline for safe use in humans.
C1 [Park, Jin-Sung; Kwon, Euna; Kim, Yun-Soon; Kang, Byeong-Cheol] Seoul Natl Univ Hosp, Biomed Res Inst, Dept Expt Anim Res, Seoul, South Korea.
   [Park, Jin-Sung; Kang, Byeong-Cheol] Seoul Natl Univ, Grad Sch Translat Med, Coll Med, Seoul, South Korea.
   [Kim, Sang-Moo; Kim, Dae-Sun] Pharm Cross Ltd, Chunchon, South Korea.
   [Jang, Ja-June] Seoul Natl Univ, Dept Pathol, Coll Med, Seoul, South Korea.
   [Yun, Jun-Won] Catholic Univ Korea, Dept Biotechnol, Bucheon, South Korea.
   [Kang, Byeong-Cheol] Seoul Natl Univ, Biomed Ctr Anim Resource & Dev, Coll Med, Seoul, South Korea.
   [Kang, Byeong-Cheol] Seoul Natl Univ, Designed Anim & Transplantat Res Inst, Inst GreenBio Sci Technol, Seoul, South Korea.
C3 Seoul National University (SNU); Seoul National University Hospital;
   Seoul National University (SNU); Seoul National University (SNU);
   Catholic University of Korea; Seoul National University (SNU); Seoul
   National University (SNU)
RP Kang, BC (corresponding author), Seoul Natl Univ Hosp, Biomed Res Inst, Dept Expt Anim Res, Seoul, South Korea.; Kang, BC (corresponding author), Seoul Natl Univ, Grad Sch Translat Med, Coll Med, Seoul, South Korea.; Kang, BC (corresponding author), Seoul Natl Univ, Biomed Ctr Anim Resource & Dev, Coll Med, Seoul, South Korea.; Kang, BC (corresponding author), Seoul Natl Univ, Designed Anim & Transplantat Res Inst, Inst GreenBio Sci Technol, Seoul, South Korea.
EM bckang@snu.ac.kr
FU Pharm Cross., Ltd.
FX This study was financially supported by Pharm Cross., Ltd.
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NR 40
TC 1
Z9 3
U1 0
U2 7
PU FRONTIERS MEDIA SA
PI LAUSANNE
PA AVENUE DU TRIBUNAL FEDERAL 34, LAUSANNE, CH-1015, SWITZERLAND
EI 1663-9812
J9 FRONT PHARMACOL
JI Front. Pharmacol.
PD AUG 31
PY 2021
VL 12
AR 687261
DI 10.3389/fphar.2021.687261
PG 15
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA UT1JQ
UT WOS:000697880000001
PM 34531739
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Cui, ZF
   Jin, NN
   Amevor, FK
   Shu, G
   Du, XX
   Kang, XC
   Ning, ZF
   Deng, X
   Tian, YF
   Zhu, Q
   Wang, Y
   Li, DY
   Zhang, Y
   Wang, XQ
   Han, X
   Feng, J
   Zhao, XL
AF Cui, Zhifu
   Jin, Ningning
   Amevor, Felix Kwame
   Shu, Gang
   Du, Xiaxia
   Kang, Xincheng
   Ning, Zifan
   Deng, Xun
   Tian, Yaofu
   Zhu, Qing
   Wang, Yan
   Li, Diyan
   Zhang, Yao
   Wang, Xiaoqi
   Han, Xue
   Feng, Jing
   Zhao, Xiaoling
TI Dietary supplementation of salidroside alleviates liver lipid metabolism
   disorder and inflammatory response to promote hepatocyte regeneration
   via PI3K/AKT/Gsk3-β pathway
SO POULTRY SCIENCE
LA English
DT Article
DE layer; fatty liver hemorrhagic syndrome; salidroside; inflammatory
   response; hepatocyte proliferation
ID FATTY LIVER; OXIDATIVE STRESS; OLEIC-ACID; HEMORRHAGIC SYNDROME;
   RHODIOLA-ROSEA; APOPTOSIS; PROTEIN; ACCUMULATION; DISEASE; INJURY
AB Fatty liver hemorrhagic syndrome (FLHS) is a chronic hepatic disease which occurs when there is a disorder in lipid metabolism. FLHS is often observed in caged laying hens and characterized by a decrease in egg production and dramatic increase of mortality. Salidroside (SDS) is an herbal drug which has shown numerous pharmacological activities, such as protecting mitochondria' function, attenuating cell apoptosis and inflammation, and promoting antioxidant defense system. We aimed to determine the therapeutic effects of SDS on FLHS in laying hens and investigate the underlying mechanisms through which SDS operates these functions. We constructed oleic acid (OA)-induced fatty liver model in vitro and high-fat diet-induced FLHS of laying hens in vivo. The results indicated that SDS inhibited OA-induced lipid accumulation in chicken primary hepatocytes, increased hepatocyte activity, elevated the mRNA expression of proliferation related genes PCNA, CDK2, and cyclinD1 and increased the protein levels of PCNA and CDK2 (P < 0.05), as well as decreased the cleavage levels of Caspase-9, Caspase-8, and Caspase-3 and apoptosis in hepatocytes (P < 0.05). Moreover, SDS promoted the phosphorylation levels of PDK1, AKT, and Gsk3-beta, while inhibited the PI3K inhibitor (P < 0.05). Additionally, we found that high-fat diet-induced FLHS hens had heavier body weight, liver weight, and abdominal fat weight, and severe steatosis in histology, compared with the control group (Con). However, hens fed with SDS maintained lighter body weight, liver weight, and abdominal fat weight, as well as normal liver without hepatic steatosis. In addition, high-fat diet-induced FLHS hens had high levels of serum total cholesterol (TC), triglyceride (TG), alanine transaminase (ALT), and aspartate aminotransferase (AST) compared to the Con group, however, in the Model+SDS group, the levels of TC, TG, ALT, and AST decreased significantly, whereas the level of superoxide dismutase (SOD) increased significantly (P < 0.05). We also found that SDS significantly decreased the mRNA expression abundance of PPAR gamma, SCD, and FAS in the liver, as well as increased levels of PPAR alpha and MTTP, and decreased the mRNA expression of TNF-alpha, IL-1 beta, IL-6, and IL-8 in the Model+SDS group (P < 0.05). In summary, this study showed that 0.3 mg/mL SDS attenuated ROS generation, inhibited lipid accumulation and hepatocyte apoptosis, and promoted hepatocyte proliferation by targeting the PI3K/AKT/Gsk3-beta pathway in OA-induced fatty liver model in vitro, and 20 mg/kg SDS alleviated high-fat-diet-induced hepatic steatosis, oxidative stress, and inflammatory response in laying hens in vivo.
C1 [Cui, Zhifu; Jin, Ningning; Amevor, Felix Kwame; Du, Xiaxia; Kang, Xincheng; Ning, Zifan; Deng, Xun; Tian, Yaofu; Zhu, Qing; Wang, Yan; Li, Diyan; Zhang, Yao; Zhao, Xiaoling] Sichuan Agr Univ, Farm Anim Genet Resources Explorat & Innovat Key, Chengdu 611130, Peoples R China.
   [Cui, Zhifu] Southwest Univ, Coll Anim Sci & Technol, Chongqing, Peoples R China.
   [Shu, Gang] Sichuan Agr Univ, Coll Vet Med, Dept Pharm, Chengdu, Sichuan, Peoples R China.
   [Wang, Xiaoqi] Agr & Anim Husb Comprehens Serv Ctr Razi Cty, Razi, Tibet Autonomou, Peoples R China.
   [Han, Xue] Guizhou Inst Anim Husb & Vet Med, Guiyang, Guizhou, Peoples R China.
   [Feng, Jing] Coll Agr & Anim Husb, Inst Anim Husb & Vet Med, Linzhi, Tibet Autonomou, Peoples R China.
C3 Sichuan Agricultural University; Southwest University - China; Sichuan
   Agricultural University
RP Zhao, XL (corresponding author), Sichuan Agr Univ, Farm Anim Genet Resources Explorat & Innovat Key, Chengdu 611130, Peoples R China.
EM zhaoxiaoling@sicau.edu.cn
RI Amevor, Felix Kwame/ACW-1169-2022; Li, Diyan/HSD-0345-2023; Du,
   Xiaxia/GXN-2129-2022
OI Amevor, Felix Kwame/0000-0003-2682-1993; Li, Diyan/0000-0001-7490-3550;
   Cui, Zhifu/0000-0002-9620-3448; 
FU Sichuan Science and Technology Program [2020JDRC0104]; Key Research &
   Development Plan of the Department of Science and Technology of Tibet
   Autonomous Region [XZ202101ZY0002N]; Local Projects Guided by the
   Central Government from Razi County, Tibet Autonomous Region; Central
   Government to Guide Local Scientific and Technological Development from
   Guizhou province [[2021]4003]
FX The authors thank the Sichuan Science and Technology Program
   (2020JDRC0104), the Key Research & Development Plan of the Department of
   Science and Technology of Tibet Autonomous Region (XZ202101ZY0002N), the
   Local Projects Guided by the Central Government from Razi County, Tibet
   Autonomous Region, and the Projects Funded by the Central Government to
   Guide Local Scientific and Technological Development from Guizhou
   province ([2021]4003) for funding this work.
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NR 70
TC 33
Z9 38
U1 4
U2 46
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0032-5791
EI 1525-3171
J9 POULTRY SCI
JI Poult. Sci.
PD SEP
PY 2022
VL 101
IS 9
AR 102034
DI 10.1016/j.psj.2022.102034
EA AUG 2022
PG 14
WC Agriculture, Dairy & Animal Science
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA 6L5DA
UT WOS:000888202100005
PM 35926351
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wu, XL
   Jiang, QQ
   Hu, H
   Han, Q
   Zhou, XH
AF Wu, Xiaolin
   Jiang, Qinqun
   Hu, Hong
   Han, Qi
   Zhou, Xihong
TI Effect of Replacing Corn with Rice on Growth Performance, Meat Quality,
   Gut Microbiota and Metabolites in Growing-Finishing Pigs
SO ANIMALS
LA English
DT Article
DE cellulase; growth performance; gut microbiota; paddy rice; pork quality
ID GC-MS; FEED
AB This study aimed to investigate the effects of partially replacing corn with rice in the diet and supplementing with cellulase on growth performance, pork quality, and gut microbiota of growing-finishing pigs. A total of 64 healthy pigs (68.03 +/- 1.59 kg) were randomly assigned into four groups: CON (basal diet), ASE (basal diet + 20,000 IU/g cellulase), RICE (the basal diet replaced 50% of corn with rice), RASE (the basal diet replaced 50% of corn with rice + 20,000 IU/g cellulase). The results indicated that dietary rice and cellulase, either individually or in combination, had no significant effects (p > 0.05) on the FBW, ADG, ADFI, and F/G of pigs. However, the dietary rice markedly increased the intramuscular fat (IMF) content (p < 0.05). Furthermore, gut microbiota profiling indicated that Papillibacte were enriched in the RICE group and positively associated with IMF content. Metabolomic analysis revealed substantial differences in fecal metabolites among the treatment groups. The RICE group exhibited reduced levels of Zygadenine, Carpaine, and Rhodioloside E, which were negatively correlated with both IMF content and Papillibacter. In conclusion, dietary rice can promote IMF deposition by modulating gut microbiota and host metabolism, without compromising the growth performance of pigs.
C1 [Wu, Xiaolin; Hu, Hong; Zhou, Xihong] Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.
   [Wu, Xiaolin; Hu, Hong; Han, Qi; Zhou, Xihong] Chinese Acad Sci, Inst Subtrop Agr, Changsha 410125, Peoples R China.
   [Jiang, Qinqun] Pingdingshan Acad Agr Sci, Pingdingshan 467000, Henan, Peoples R China.
C3 Hunan Agricultural University; Chinese Academy of Sciences; Institute of
   Subtropical Agriculture, CAS
RP Zhou, XH (corresponding author), Hunan Agr Univ, Coll Anim Sci & Technol, Changsha 410128, Peoples R China.; Han, Q; Zhou, XH (corresponding author), Chinese Acad Sci, Inst Subtrop Agr, Changsha 410125, Peoples R China.
EM v2637227@gmail.com; jiaweiflying@163.com; huhong7777777@126.com;
   hanqiqi@isa.ac.cn; xhzhou@isa.ac.cn
OI Han, Qi/0000-0003-0144-4175
FU China Agriculture Research System of MOF and MARA [CARS-35]; National
   Key Research and Development Program of China [2023YFD1301305]; Science
   and Technology Innovation Program of Hunan Province [2023RC1074]
FX This study was financially supported by the National Key Research and
   Development Program of China (2023YFD1301305), the Science and
   Technology Innovation Program of Hunan Province (2023RC1074) and China
   Agriculture Research System of MOF and MARA (CARS-35).
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NR 53
TC 1
Z9 1
U1 3
U2 3
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
SN 2076-2615
J9 ANIMALS-BASEL
JI Animals
PD DEC 19
PY 2025
VL 16
IS 1
AR 12
DI 10.3390/ani16010012
PG 20
WC Agriculture, Dairy & Animal Science; Veterinary Sciences; Zoology
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture; Veterinary Sciences; Zoology
GA AW4RQ
UT WOS:001658399500001
PM 41514700
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Wu, JG
   Xun, N
   Yang, Y
   Zeng, LJ
   Li, ZY
   Yang, W
   Liang, YB
   Tang, H
   Ma, ZF
AF Wu, Jingguo
   Xun, Nan
   Yang, Yang
   Zeng, Lijin
   Li, Zhenyu
   Yang, Wen
   Liang, Yanbing
   Tang, Hao
   Ma, Zhongfu
TI RETRACTED: Chrysin attenuates myocardial ischemia-reperfusion injury by
   inhibiting myocardial inflammation (Retracted article. See vol. 11, pg.
   4173, 2021)
SO RSC ADVANCES
LA English
DT Article; Retracted Publication
ID HMGB1; QUERCETIN; LIPOPOLYSACCHARIDE; SALIDROSIDE; APOPTOSIS; RECEPTOR;
   RATS
AB The aim of this study was to investigate the effects of chrysin (CH) on myocardial ischemia-reperfusion injury. Cytokines were reduced by CH in coronary artery occlusion-induced rats and also in H9C2 cells. The ST segment was also restored by CH. Triphenyltetrazolium chloride (TTC) staining and pathological analysis showed that CH could alleviate myocardial injury. Results in H9C2 cells showed that CH improved heart injury in hypoxia/reoxygenation (H/R) of H9C2 cells. In addition, the expressions of the HMGB1-related inflammation pathway in rats and H9C2 cells were significantly decreased by CH. The present study shows the protective effects of CH on myocardial injury via inflammation.
C1 [Wu, Jingguo; Zeng, Lijin; Li, Zhenyu; Yang, Wen; Liang, Yanbing; Tang, Hao; Ma, Zhongfu] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gen Internal Med, Guangzhou 510080, Guangdong, Peoples R China.
   [Xun, Nan] Sun Yat Sen Univ, Dept Endocrinol, Affiliated Hosp 1, Guangzhou 510080, Guangdong, Peoples R China.
   [Yang, Yang] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Pathol, Guangzhou 510080, Guangdong, Peoples R China.
C3 Sun Yat Sen University; Sun Yat Sen University; Sun Yat Sen University
RP Tang, H; Ma, ZF (corresponding author), Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gen Internal Med, Guangzhou 510080, Guangdong, Peoples R China.
EM haohao_t@yeah.net; formalin_00@126.com
RI Yang, Wen/ABE-7541-2021
FU Guangdong Provincial Science and Technology Project [2016A020215054]
FX This work was supported by Guangdong Provincial Science and Technology
   Project (2016A020215054).
CR Andrassy M, 2008, CIRCULATION, V117, P3216, DOI 10.1161/CIRCULATIONAHA.108.769331
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NR 18
TC 10
Z9 13
U1 0
U2 8
PU ROYAL SOC CHEMISTRY
PI CAMBRIDGE
PA THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS,
   ENGLAND
EI 2046-2069
J9 RSC ADV
JI RSC Adv.
PY 2018
VL 8
IS 25
BP 13739
EP 13746
DI 10.1039/c8ra00590g
PG 8
WC Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Chemistry
GA GD5HP
UT WOS:000430538300015
PM 35539337
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Atochin, DN
   Chernysheva, GA
   Smolyakova, VI
   Osipenko, AN
   Logvinov, SV
   Zhdankina, AA
   Sysolyatin, SV
   Kryukov, YA
   Anfinogenova, Y
   Plotnikova, TM
   Plotnikov, MB
AF Atochin, Dmitriy N.
   Chernysheva, Galina A.
   Smolyakova, Vera I.
   Osipenko, Anton N.
   Logvinov, Sergey V.
   Zhdankina, Anna A.
   Sysolyatin, Sergey V.
   Kryukov, Yuri A.
   Anfinogenova, Yana
   Plotnikova, Tatiana M.
   Plotnikov, Mark B.
TI Neuroprotective effects of p-tyrosol after the global cerebral
   ischemia in rats
SO PHYTOMEDICINE
LA English
DT Article
DE p-tyrosol; Pentoxifylline; Global cerebral ischemia; Antioxidant effect;
   Neuroprotective effect
ID OLIVE OIL; REPERFUSION; ANTIOXIDANT; INHIBITION; SURVIVAL; INJURY; CELLS
AB Background: Salidroside is a biologically active compound derived from Rhodiola rosea L. Studies showed that salidroside after i.v. injection is extensively metabolized to p-tyrosol and only trace amounts of salidroside are found in the brain tissue.
   Objective: The aim of the study was to investigate the neuroprotective effects of p-tyrosol in the global cerebral ischemia-reperfusion (GCI) model.
   Study design: A total of 103 Wistar rats were assigned to groups of sham-operated (n = 10), control (n = 42), p-tyrosol-treated (n = 36), and pentoxifylline-treated (n = 15) animals. The rats of control, p-tyrosol-treated, and pentoxifylline-treated groups received intravenously 0.9% NaCl solution, 2% solution of p-tyrosol in doses of 5 mg/kg, 10 mg/kg, and 20 mg/kg, and pentoxifylline in a dose of 100 mg/kg, respectively, daily for 5 days. Rats were examined at days 1, 3, and 5 after GCI. After evaluation of neurological deficit, animals were euthanized for morphological and biochemical characterization.
   Methods: Rats of control, p-tyrosol-treated, and pentoxifylline-treated groups were exposed to three-vessel model of GCI. Neurological deficit, numeric density of neurons in hippocampal CA1 region, and percentage of neurons with focal and total chromatolysis were studied. Biochemical study assessed contents of conjugated dienes and fluorescent products in brain homogenate.
   Results: In control group, only 50.0% of rats survived by day 5 after the GCI; 38.1% of survived animals had severe neurologic deficit. In brain tissue of PTX-treated rats, the levels of diene conjugates and fluorescent products were 79% and 73%, respectivley, at day 5 compared with control. Differences in diene conjugates were statistically significant compared with control. The survival rate of animals treated with 20 mg/kg p-tyrosol was 82.3% at day 5 after GCI. In p-tyrosol-treated GCI rats, the numeric density of neurons in the hippocampal CA1 region was higher by 31% compared with control. The percentage of neurons with focal and total chromatolysis decreased by 27% and 43%, respectively. At day 5 after GCI, the levels of conjugated dienes and fluorescent products were significantly lower (by 37% and 45%, respectively) in group of animals treated with 20 mg/kg p-tyrosol compared with control. Moderate neuroprotective effects of 5 mg/kg p-tyrosol administration were documented only at day 5 after GCI. In case of 10 mg/kg p-tyrosol administration, neuroprotection was documented sooner: at day 1 or 3 after GCI. However, administration of 5 and 10 mg/kg p-tyrosol did not affect animal survival.
   Conclusion: Course administration of intravenous p-tyrosol in a dose of 20 mg/kg increased survival, reduced neurological deficit after GCI, attenuated neuronal damage in the hippocampus, and attenuated lipid peroxidation in brain tissue in animals subject to GCI with reperfusion. (C) 2016 Elsevier GmbH. All rights reserved.
C1 [Atochin, Dmitriy N.] Harvard Univ, Massachusetts Gen Hosp, Cardiovasc Res Ctr, Sch Med, Charlestown, MA USA.
   [Atochin, Dmitriy N.] Harvard Univ, Massachusetts Gen Hosp, Div Cardiol, Sch Med, Charlestown, MA USA.
   [Chernysheva, Galina A.; Smolyakova, Vera I.; Plotnikov, Mark B.] Fed State Budgetary Sci Inst, ED Goldberg Inst Pharmacol & Regenerat Med, 3 Lenin St, Tomsk 634028, Russia.
   [Osipenko, Anton N.; Logvinov, Sergey V.; Zhdankina, Anna A.; Plotnikova, Tatiana M.] Siberian State Med Univ, 2 Moscowsky Trakt, Tomsk 634050, Russia.
   [Sysolyatin, Sergey V.; Kryukov, Yuri A.] Russian Acad Sci, Siberian Branch, Inst Problems Chem & Energet Technol, 1 Socialisticheskaya St, Biisk, Russia.
   [Anfinogenova, Yana] Fed State Budgetary Sci Inst, Cardiol Res Inst, 111a Kievskaya St, Tomsk 634012, Russia.
   [Anfinogenova, Yana] Tomsk Polytech Univ, RASA Ctr Tomsk, 30 Lenin St, Tomsk 634050, Russia.
C3 Harvard University; Harvard University Medical Affiliates; Massachusetts
   General Hospital; Harvard University; Harvard University Medical
   Affiliates; Massachusetts General Hospital; Russian Academy of Sciences;
   Tomsk National Research Medical Center; E. D. Goldberg Research
   Institute of Pharmacology & Regenerative Medicine; Siberian State
   Medical University; Institute for Problems of Chemical & Energetic
   Technologies of the Siberian Branch of the Russian Academy of Sciences;
   Russian Academy of Sciences; Russian Academy of Sciences; Tomsk National
   Research Medical Center; E. D. Goldberg Research Institute of
   Pharmacology & Regenerative Medicine; Cardiology Research Institute -
   Tomsk; Tomsk Polytechnic University
RP Plotnikov, MB (corresponding author), Fed State Budgetary Sci Inst, ED Goldberg Inst Pharmacol & Regenerat Med, 3 Lenin St, Tomsk 634028, Russia.
EM mbp2001@mail.ru
RI ; Plotnikov, Mark/P-8957-2016; Osipenko, Anton/D-3544-2015; Plotnikov,
   Mark/P-8957-2016; Chernysheva, Galina/Q-7270-2016; Anfinogenova, Nina
   D/E-7458-2014; Smolyakova Smol’yakova Smol'iakova Smol'jakova,
   Vera/I-9414-2017; Anna, Zhdankina/N-3103-2016; Sysolyatin,
   Sergey/H-9688-2014; Atochin, Dmitriy/AAH-8843-2020; Vera,
   Smolyakova/I-9414-2017; /N-1055-2016; /AAN-6843-2020
OI Plotnikova, Tatiana/0000-0003-4223-6639; Plotnikov,
   Mark/0000-0002-0548-6586; Osipenko, Anton/0000-0002-4763-3214;
   Plotnikov, Mark/0000-0002-0548-6586; Chernysheva,
   Galina/0000-0002-6438-5734; Anfinogenova, Nina D/0000-0003-1106-0730;
   Smolyakova Smol’yakova Smol'iakova Smol'jakova,
   Vera/0000-0001-9501-4664; Anna, Zhdankina/0000-0002-4954-7416;
   Sysolyatin, Sergey/0000-0002-1405-171X; 
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NR 37
TC 31
Z9 36
U1 1
U2 27
PU ELSEVIER GMBH
PI MUNICH
PA HACKERBRUCKE 6, 80335 MUNICH, GERMANY
SN 0944-7113
EI 1618-095X
J9 PHYTOMEDICINE
JI Phytomedicine
PD JUN 15
PY 2016
VL 23
IS 7
BP 784
EP 792
DI 10.1016/j.phymed.2016.03.015
PG 9
WC Plant Sciences; Chemistry, Medicinal; Integrative & Complementary
   Medicine; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy; Integrative & Complementary
   Medicine
GA DM7IM
UT WOS:000376533500012
PM 27180226
DA 2026-05-27
ER

PT J
AU Peschel, W
   Kump, A
   Zomborszki, ZP
   Pfosser, M
   Kainz, W
   Csupor, D
AF Peschel, Wieland
   Kump, Alfred
   Zomborszki, Zoltan Peter
   Pfosser, Martin
   Kainz, Wolfgang
   Csupor, Dezso
TI Phenylpropenoid content in high-altitude cultivated Rhodiola rosea L.
   provenances according to plant part, harvest season and age
SO INDUSTRIAL CROPS AND PRODUCTS
LA English
DT Article
DE Rhodiola rosea L.; Cultivation; Standardisation; Rosavin; Cinnamyl
   alcohol; Phenylpropenoids
ID ROOTS; EXTRACTS; ALCOHOL
AB The phenylpropenoid glycosides rosavin, rosarin, rosin summarised as 'total rosavins' are quality indicators of Rhodiola rosea L. Here we report the systematic quantification of these glycosides and the aglycon cinnamyl alcohol in various provenances cultivated homogenously at 1580 m altitude.
   (I) We examined rhizomes versus roots in cultivation year 9 (20 provenances). Extracts (70% ethanol) contained 0.5-4.3 mg/mL (rhizomes) and 0.4-2.5 mg/mL (roots) total rosavins. The rosavin/cinnamyl alcohol ratio (average rhizomes 8.1:1, roots 6.2:1), was more influenced by plant origin than plant part. We additionally analysed salidroside including its aglycon tyrosol. The rosavins/salidroside ratios (including aglycons) of 6.4:1 (rhizome) and 5.5:1 (root) indicated authentic R. rosea independent of plant part and origin.
   (II) Rhizomes extracts (8 provenances) from various dates during years 6 and 7 contained 0.4-4.8 mg/mL total rosavins corresponding to 0.2-3.0% in the dry drug. Age (decreasing trend) and provenance impact were superposed by seasonal variation with a phenylpropenoid peak in spring. Rosavin/cinnamyl alcohol ratios in North European plants were 3-8:1, for Alpine/Pyrenean plants 9-14:1.
   (III) Compared to our previous dataset from cultivation in South England, on average, there was no major difference between phenylpropenoid, values from cultivation at 65 m and 1580 m apart from moderately more cinnamyl alcohol at higher altitude. As per provenance, absolute values were site dependent but phenylpropenoid glycoside/aglycon ratios consistent.
   In conclusion, this is the first systematic investigation for a high altitude cultivation of R. rosea demonstrating the major extent plant part, season and age influence absolute phenylpropenoid values. In contrary, relative phenolic compound profiles are mostly origin-determined, independent of cultivation conditions and site, and could be used for authentication in quality control.
C1 [Peschel, Wieland] European Med Agcy, 30 Churchill Pl, London E14 5EU, England.
   [Kump, Alfred; Pfosser, Martin] Bioctr Linz, Oberosterreich Landesmuseum, Bot Arbeitsgemeinschaft, JW Klein Str 73, A-4040 Linz, Austria.
   [Zomborszki, Zoltan Peter; Csupor, Dezso] Univ Szeged, Fac Pharm, Dept Pharmacognosy, Eotvos U 6, H-6720 Szeged, Hungary.
   [Kainz, Wolfgang] Osterreich Agentur Gesundheit & Ernahrutzgssicher, Pflanzengenet Ressourcen, Wieningerstr 8, A-4020 Linz, Austria.
C3 Szeged University
RP Peschel, W (corresponding author), European Med Agcy, 30 Churchill Pl, London E14 5EU, England.
EM wieland.peschel@ema.europa.eu
RI ; Csupor, Dezső/ABE-1830-2021
OI Pfosser, Martin/0000-0003-2050-4997; Csupor, Dezső/0000-0002-4088-3333;
   Zomborszki, Zoltán Péter/0000-0002-7412-9793
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NR 29
TC 16
Z9 19
U1 5
U2 31
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 0926-6690
EI 1872-633X
J9 IND CROP PROD
JI Ind. Crop. Prod.
PD JAN
PY 2018
VL 111
BP 446
EP 456
DI 10.1016/j.indcrop.2017.10.007
PG 11
WC Agricultural Engineering; Agronomy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA FR9QG
UT WOS:000419407600056
DA 2026-05-27
ER

PT J
AU Soroudi, S
   Mousavi, G
   Jafari, F
   Elyasi, S
AF Soroudi, Setareh
   Mousavi, Ghazal
   Jafari, Fatemeh
   Elyasi, Sepideh
TI Prevention of colistin-induced neurotoxicity: a narrative review of
   preclinical data
SO NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
LA English
DT Review
DE Colistin; Neurotoxicity; Neuroprotective agents; Antioxidants;
   Polymyxins; Colistimethate sodium
ID NERVE GROWTH-FACTOR; SULFATE-INDUCED NEUROTOXICITY; OXIDATIVE STRESS;
   INDUCED APOPTOSIS; RHODIOLA-ROSEA; MITOCHONDRIAL DYSFUNCTION;
   SALIDROSIDE PROTECTS; ASCORBIC-ACID; PC12 CELLS; CURCUMIN
AB Polymyxin E or colistin is an effective antibiotic against MDR Gram-negative bacteria. Due to unwanted side effects, the use of this antibiotic has been limited for a long time, but in recent years, the widespread of MDR Gram-negative bacteria infections has led to its reintroduction. Neurotoxicity and nephrotoxicity are the significant dose-limiting adverse effects of colistin. Several agents with anti-inflammatory and antioxidant properties have been used for the prevention of colistin-induced neurotoxicity. This study aims to review the preclinical studies in this field to prepare guidance for future human studies. The data was achieved by searching PubMed, Scopus, and Google Scholar databases. All eligible pre-clinical studies performed on neuroprotective agents against colistin-induced neurotoxicity, which were published up to September 2023, were included. Finally, 16 studies (ten in vitro and eight in vivo) are reviewed. Apoptosis (in 13 studies), inflammatory (in four studies), and oxidative stress (in 14 studies) pathways are the most commonly reported pathways involved in colistin-induced neurotoxicity. The assessed compounds include non-herbal (e.g., ascorbic acid, rapamycin, and minocycline) and herbal (e.g., curcumin, rutin, baicalein, salidroside, and ginsenoside) agents. Besides these compounds, some other measures like transplantation of mitochondria and the use of nerve growth factor and mesenchymal stem cells could be motivating subjects for future research. Based on the data from experimental (in vitro and animal) studies, a combination of colistin with neuroprotective agents could prevent or decrease colistin-induced neurotoxicity. However, well-designed randomized clinical trials and human studies are essential for demonstrating efficacy.
C1 [Soroudi, Setareh; Mousavi, Ghazal; Jafari, Fatemeh; Elyasi, Sepideh] Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, Mashhad 917751365, Iran.
C3 Mashhad University of Medical Sciences
RP Elyasi, S (corresponding author), Mashhad Univ Med Sci, Sch Pharm, Dept Clin Pharm, Mashhad 917751365, Iran.
EM elyasis@mums.ac.ir
RI /AAT-2832-2021; elyasi, sepideh/AAM-8916-2021
OI elyasi, sepideh/0000-0001-9857-1175
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NR 95
TC 6
Z9 7
U1 2
U2 9
PU SPRINGER
PI NEW YORK
PA ONE NEW YORK PLAZA, SUITE 4600, NEW YORK, NY, UNITED STATES
SN 0028-1298
EI 1432-1912
J9 N-S ARCH PHARMACOL
JI Naunyn-Schmiedebergs Arch. Pharmacol.
PD JUN
PY 2024
VL 397
IS 6
BP 3709
EP 3727
DI 10.1007/s00210-023-02884-w
EA DEC 2023
PG 19
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA RS4A9
UT WOS:001126678900003
PM 38091077
DA 2026-05-27
ER

PT J
AU Chu, HB
   Zhang, ZH
   Chen, D
   Wang, X
   Tu, QL
AF Chu, Hongbiao
   Zhang, Zhihua
   Chen, Dong
   Wang, Xi
   Tu, Qilong
TI Content Determination of Phenylpropanoids and Enhancing Exercise Ability
   of Effective Fractions in Pedicularis densispica
SO PHARMACOGNOSY MAGAZINE
LA English
DT Article
DE Anoxia endurance; effective fractions of phenylpropanoids
ID ANTIOXIDANT ACTIVITY; PHENOLIC-COMPOUNDS; EXTRACTION; GLYCOSIDES;
   SALIDROSIDE; RAT; CHROMATOGRAPHY; HYPOXIA; PEELS
AB Background: Most researches were focused on chemical constituents and bioactivities of Pedicularis. However, there were a few reports on simultaneous determination of the series phenylpropanoids compounds in Pedicularis by High Performance Liquid Chromatography (HPLC). Objective: To establish an HPLC method for simultaneous determination of salidroside, verbascoside, iso-verbascoside, leucoseptoside A, jionoside D and martynoside in Pedicularis densispica (PD), and to assess the enhancing exercise ability of effective fractions of phenylpropanoids (EFP). Materials and Methods: The separation was performed on C 18 column with step-wise gradient elution with water (A)-methanol (B) as the mobile phase at a flow rate of 1.0 mL/min, with detection wavelength at 275 nm (0-4 min) and 330 nm (4-40 min). The EFP were obtained from extracts of PD by resin gradient dilution. The enhancing exercise ability of EFP was exerted in exhaustive swimming and anoxia endurance tests in vivo. Results: The contents of six marker compounds had good linear relationship in the ranges of 2.10-8.40, 13.60-54.40, 0.93-3.72, 0.53-2.12, 1.50-6.00, 0.37-1.28, respectively, and the average recoveries of the six phenylpropanoids were all in the range of 98-103%. Total contents of phenylpropanoids in EFP were more than 60%. Three medicine groups of exhaustive swimming and anoxia endurance time were higher than those of the water group. Conclusion: The analytical method is reliable, simple and accurate, and can be used for the comprehensive quality control of PD. This experiment suggests that PD has the effect of promoting the recovery and elimination of fatigue and improving the exercise capacity.
C1 [Chu, Hongbiao; Zhang, Zhihua; Chen, Dong; Wang, Xi; Tu, Qilong] Jinggangshan Univ, Sch Med, Dept Pharm, Jian, Jiangxi, Peoples R China.
C3 Jinggangshan University
RP Chu, HB (corresponding author), Jinggangshan Univ, Sch Med, Nat Prod Chem, 28 Xueyuan Rd, Jian, Jiangxi, Peoples R China.
EM hongbiaochu@163.com
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NR 30
TC 1
Z9 3
U1 1
U2 11
PU MEDKNOW PUBLICATIONS & MEDIA PVT LTD
PI MUMBAI
PA B-9, KANARA BUSINESS CENTRE, OFF LINK RD, GHAKTOPAR-E, MUMBAI, 400075,
   INDIA
SN 0973-1296
EI 0976-4062
J9 PHARMACOGN MAG
JI Pharmacogn. Mag.
PD APR-JUN
PY 2017
VL 13
IS 50
BP 230
EP 235
DI 10.4103/0973-1296.204567
PG 6
WC Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA FC5HE
UT WOS:000406871700006
PM 28539713
DA 2026-05-27
ER

PT J
AU Maliwong, J
   Chimnoi, N
   Thamniyom, W
   Ruchirawat, S
   Kanchanapoom, T
AF Maliwong, Jedsada
   Chimnoi, Nitirat
   Thamniyom, Wassapol
   Ruchirawat, Somsak
   Kanchanapoom, Tripetch
TI Megastigmane and 7,9'-dinorlignan glycosides from the tubers of
   Stephania kaweesakii
SO PHYTOCHEMISTRY LETTERS
LA English
DT Article
DE Stephania kaweesakii; Menispermaceae; Megastigmane glycoside; 7,9
   '-dinorlignan glycoside; Stepdinorlignoside; Stephania alkaloid;
   (+)-magnocurarine
ID MYCORRHIZAL ROOTS; ALKALOIDS; MENISPERMACEAE; LIGNANS; LEAVES; STEMS
AB Two isomers of megastigmane glycosides, (6R, 9S)-blumenol C 9-O-gentibioside (2) and (6S, 9S)-blumenol C 9-O- gentiobioside (3), and a new 7,9'-dinorlignan glycoside, stepdonorlignoside (4) were isolated from the tubers Stephania kaweesakii. The structure determinations were considered based on the physical data and spectroscopic evidence. The absolute configurations of two megastigmanes were determined for the first time. Additionally, known compounds were isolated: (6R, 9S)-blumenol C 9-O-13-D-glucopyranoside, (+)-isolariciresinol 3a-O-13-D-glucopyranoside, salidroside, N-trans-caffeoyltyramine, (R)-isococlaurine, (R)-isococlaurine 4 & PRIME;-O-beta-glucopyr-anoside, (-)-oblongine, (+)-magnocurarine, fordianoside, and (-)-cyclanoline.
C1 [Maliwong, Jedsada; Chimnoi, Nitirat; Thamniyom, Wassapol; Ruchirawat, Somsak; Kanchanapoom, Tripetch] Chulabhorn Res Inst, Kamphaeng Phet 6, Bangkok 10210, Thailand.
   [Kanchanapoom, Tripetch] Khon Kaen Univ, Fac Pharmaceut Sci, Khon Kaen 40002, Thailand.
C3 Chulabhorn Research Institute; Khon Kaen University
RP Kanchanapoom, T (corresponding author), Chulabhorn Res Inst, Kamphaeng Phet 6, Bangkok 10210, Thailand.
EM trikan@kku.ac.th
OI Ruchirawat, Somsak/0000-0001-5842-4330; Maliwong,
   Jedsada/0009-0003-3452-1090
FU Thailand Science Research and Innovation (TSRI); Chulabhorn Research
   Institute [313/2220]; Khon Kaen University
FX This research project was supported by Thailand Science Research and
   Innovation (TSRI), Chulabhorn Research Institute (Grant No. 313/2220),
   and Khon Kaen University.
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Z9 4
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U2 14
PU ELSEVIER
PI AMSTERDAM
PA RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
SN 1874-3900
EI 1876-7486
J9 PHYTOCHEM LETT
JI Phytochem. Lett.
PD JUN
PY 2022
VL 49
BP 109
EP 113
DI 10.1016/j.phytol.2022.03.023
EA APR 2022
PG 5
WC Plant Sciences; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Pharmacology & Pharmacy
GA 1D3TK
UT WOS:000793726100001
DA 2026-05-27
ER

PT J
AU Pasdaran, A
   Delazar, A
   Ayatollahi, SA
   Nahar, L
   Sarker, SD
AF Pasdaran, Ardalan
   Delazar, Abbas
   Ayatollahi, Seyed Abdulmajid
   Nahar, Lutfun
   Sarker, Satyajit D.
TI Phytochemical and Bioactivity Evaluation of Scrophularia
   amplexicaulis Benth.
SO RECORDS OF NATURAL PRODUCTS
LA English
DT Article
DE Scrophularia amplexicaulis; Scrophulariaceae; iridoid; phenylalkanoid;
   glycoside; DPPH (2,2-diphenyl-1-picrylhydrazyl); antimalarial
ID CHEMICAL-COMPOSITION; PHENYLETHANOID GLYCOSIDES; FERRIPROTOPORPHYRIN IX;
   IRIDOID GLYCOSIDES; HEMATIN FORMATION; INHIBITION; ANTIBACTERIAL;
   ANTIMALARIALS; VERBASCOSIDE; QUINOLINE
AB Scrophularia amplexicaulis Benth. is an Iranian endemic species of the genus Scrophularia, which comprises ca. 200 medicinally important herbaceous flowering plants. Phytochemical investigation of the methanol extract of the aerial parts of this species afforded two iridoid glycosides, scropolioside D (1) and scrophuloside B-4 (2), and two phenylalkanoid glycosides, salidroside (3) and verbascoside (4). Structures of these compounds were determined by comprehensive spectroscopic analyses. Free-radical-scavenging activity, potential antimalarial property, and contact toxicity as well as general toxicity of the extract and fractions were assessed. (C) 2016 ACG Publications. All rights reserved.
C1 [Pasdaran, Ardalan] Guilan Univ Med Sci, Dept Pharmacognosy, Res & Dev Ctr Plants & Med Chem, Sch Pharm, Rasht, Iran.
   [Delazar, Abbas] Tabriz Univ Med Sci, Fac Pharm, Dept Pharmacognosy, Tabriz, Iran.
   [Ayatollahi, Seyed Abdulmajid] Shahid Beheshti Univ Med Sci, Sch Pharm, Dept Pharmacognosy, Tehran, Iran.
   [Ayatollahi, Seyed Abdulmajid] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Med Chem & Nat Prod Res Grp, James Persons Bldg,Byrom St, Liverpool L3 3AF, Merseyside, England.
   [Nahar, Lutfun; Sarker, Satyajit D.] Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Med Chem & Nat Prod Res Grp, James Persons Bldg,Byrom St, Liverpool L3 3AF, Merseyside, England.
C3 Guilan University of Medical Sciences; Tabriz University of Medical
   Science; Shahid Beheshti University Medical Sciences; Liverpool John
   Moores University; Liverpool John Moores University
RP Sarker, SD (corresponding author), Liverpool John Moores Univ, Sch Pharm & Biomol Sci, Med Chem & Nat Prod Res Grp, James Persons Bldg,Byrom St, Liverpool L3 3AF, Merseyside, England.
EM S.Sarker@ljmu.ac.uk
RI Ayatollahi, Seyed Abdulmajid/W-4827-2019; Sarker,
   Satyajit/ABC-6278-2021; Nahar, Lutfun/AHE-0048-2022; Pasdaran,
   Ardalan/K-5063-2019
OI Ayatollahi, Seyed Abdulmajid/0000-0003-2018-2406; Sarker,
   Satyajit/0000-0003-4038-0514; Nahar, Lutfun/0000-0002-1157-2405;
   Pasdaran, Ardalan/0000-0001-6713-0756
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NR 28
TC 8
Z9 9
U1 0
U2 8
PU ACG PUBLICATIONS
PI GEBZE-KOCAELI
PA YENIKENT MAHALLESI, FIRAT CADDESI, 1-3, GEBZE-KOCAELI, 41400, TURKEY
SN 1307-6167
J9 REC NAT PROD
JI Rec. Nat. Prod.
PY 2016
VL 10
IS 4
BP 519
EP 525
PG 7
WC Plant Sciences; Chemistry, Applied; Chemistry, Medicinal
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Plant Sciences; Chemistry; Pharmacology & Pharmacy
GA DH5CW
UT WOS:000372803800014
DA 2026-05-27
ER

PT J
AU Kuncic, A
   Bucar, F
   Mozina, SS
AF Kuncic, Ajda
   Bucar, Franz
   Mozina, Sonja Smole
TI Rhodiola rosea Reduces Intercellular Signaling in
   Campylobacter jejuni
SO ANTIBIOTICS-BASEL
LA English
DT Article
DE Rhodiola rosea; proanthocyanidins; flavonoids; Campylobacter jejuni;
   LuxS; intercellular signaling
ID BIOFILM FORMATION; LIQUID-CHROMATOGRAPHY; QUORUM; L.; ANTIBACTERIAL;
   SALIDROSIDE; EXTRACTS; MOTILITY; ROSAVIN; LUXS
AB Campylobacter jejuni is a major foodborne pathogen and the leading cause of bacterial gastroenteritis, i.e., campylobacteriosis. Besides searching for novel antimicrobials, identification of new targets for their action is becoming increasingly important. Rhodiola rosea has long been used in traditional medicine. Ethanolic extracts from the roots and rhizomes of the plant contain a wide range of bioactive compounds with various pharmacological activities. In this study, cultivated plant materials have been used, i.e., "Mattmark" and "Rosavine". Through optimized protocols, we obtained fractions of the initial ethanolic extracts rich in most important bioactive compounds from R. rosea, including salidroside, rosavins, proanthocyanidins (PACs), and flavonoids. The antimicrobial activity in relation to the chemical composition of the extracts and their fractions was studied with an emphasis on C. jejuni AI-2-mediated intercellular signaling. At concentration 15.625 mg/L, bioluminescence reduction rates varied from 27% to 72%, and the membrane remained intact. Fractions rich in PACs had the strongest antimicrobial effect against C. jejuni, with the lowest minimal inhibitory concentrations (MICs) (M F3 40%: 62.5 mg/L; R F3 40%: 250 mg/L) and the highest intercellular signaling reduction rates (M F3 40%: 72%; R F3 40%: 65%). On the other hand, fractions without PACs were less effective (MICs: M F5 PVP: 250 mg/L; R F5 PVP: 1000 mg/L and bioluminescence reduction rates: M F5 PVP: 27%; R F5 PVP: 43%). Additionally, fractions rich in flavonoids had strong antimicrobial activity (MICs: M F4 70%: 125 mg/L; R F4 70%: 250 mg/L and bioluminescence reduction rates: M F4 70%: 68%; R F4 70%: 50%). We conclude that PACs and flavonoids are crucial compound groups responsible for the antimicrobial activity of R. rosea roots and rhizomes in C. jejuni.
C1 [Kuncic, Ajda; Mozina, Sonja Smole] Univ Ljubljana, Biotech Fac, Dept Food Sci & Technol, Jamnikarjeva Ulica 101, Ljubljana 1000, Slovenia.
   [Bucar, Franz] Karl Franzens Univ Graz, Inst Pharmaceut Sci, Dept Pharmacognosy, Beethovenstr 8, A-8010 Graz, Austria.
C3 University of Ljubljana; University of Graz
RP Mozina, SS (corresponding author), Univ Ljubljana, Biotech Fac, Dept Food Sci & Technol, Jamnikarjeva Ulica 101, Ljubljana 1000, Slovenia.
EM sonja.smole-mozina@bf.uni-lj.si
OI Bucar, Franz/0000-0002-7417-616X
FU Slovenian Research Agency (ARRS) [P4-0116, J4-2542]
FX This research was funded by the Slovenian Research Agency (ARRS) grant
   P4-0116 and research project J4-2542.
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NR 46
TC 5
Z9 6
U1 1
U2 13
PU MDPI
PI BASEL
PA ST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND
SN 2079-6382
J9 ANTIBIOTICS-BASEL
JI Antibiotics-Basel
PD SEP
PY 2022
VL 11
IS 9
AR 1220
DI 10.3390/antibiotics11091220
PG 13
WC Infectious Diseases; Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Infectious Diseases; Pharmacology & Pharmacy
GA 4U0TH
UT WOS:000858516900001
PM 36140000
OA Green Submitted, Green Published, gold
DA 2026-05-27
ER

PT J
AU Xu, P
   Wang, Y
   Sun, WW
   Sun, YW
   Lu, W
   Chang, YM
   Ping, Z
   Li, Y
   Cao, XB
AF Xu, Peng
   Wang, Yang
   Sun, Weiwei
   Sun, Yawei
   Lu, Wei
   Chang, Yumei
   Ping, Zheng
   Li, Yang
   Cao, Xuebin
TI Salidroside protects the cardiac function of exhausted rats by inducing
   Nrf2 expression
SO CARDIOVASCULAR JOURNAL OF AFRICA
LA English
DT Article
DE exhaustive exercise; heart function; nuclear factor erythroid 2-related
   factor 2; oxidative stress; rats
ID GENE-EXPRESSION; UP-REGULATION; INDUCTION; STRESS; ANTIOXIDANT;
   ACTIVATION; EXERCISE
AB Objective: To investigate whether salidroside (Sal) protected the rat heart from exhaustive exercise-induced injury by inducing nuclear factor erythroid 2-related factor 2 (Nrf2) expression.
   Methods: Forty-eight male Sprague-Dawley rats were divided into four groups (a = 12 rats per group): the control, the exhaustive swimming (ES) group, the low-dose Sal plus acute exhaustive swimming (SEE) group, and the high-dose Sal plus acute exhaustive swimming (SHE) group. In the SEE and SHE groups. 15 and 30 mg/kg Sal were administered, respectively, once a day. The rats in the control and ES groups were administered the same amount of physiological saline. respectively. once a day. On the 14th day, the rats in the ES, SEE and SHE groups underwent exhaustive swimming training once. Then cardiac function parameters and electrocardiograms were recorded. Biomarkers of myocardial injury in the serum and oxidative stress factors in the myocardial tissue were evaluated using El ISA tests. The levels of Nrf2, nuclear Nrf2 and Kelch-like ECH-associated protein 1 (Keapl) messenger RNA and proteins were assessed in the myocardium using q-PCR and Western blotting. respectively.
   Results: Compared to the control group, the ES group showed remarkable increases in serum brain natriuretic peptide (BNP), cardiac troponin I (cTnI) and reactive oxygen specks levels, but significant decreases in catalase and glutathione levels (p < 0.05). Compared to the ES group, the Sal treatment decreased serum BNP and cTnI levels and alleviated the changes in levels of oxidative stress-related factors. After treatment with Sal, nuclear and intracellular levels of Nrf2 protein were increased in the myocardial cells, while the level of Keap 1 protein was decreased (p < 0.05).
   Conclusion: Sal protected the heart from exhaustive exerciseinduced injury, and it may improve cardiac function and cardiac bioelectncity in exhausted rats by inducing Nrf2 expression.
C1 [Xu, Peng; Sun, Weiwei; Ping, Zheng; Cao, Xuebin] 252 Hosp Chinese Peoples Liberat Army, Dept Cardiol, Baoding, Hebei, Peoples R China.
   [Wang, Yang] 252 Hosp Chinese Peoples Liberat Army, Dept Clin Pharm, Baoding, Hebei, Peoples R China.
   [Sun, Yawei; Chang, Yumei] Chinese Peoples Liberat Army Gen Hosp, Dept Cent Lab, Baoding, Hebei, Peoples R China.
   [Lu, Wei] Baoding First Hosp, Dept Emergency, Baoding, Hebei, Peoples R China.
   [Li, Yang] Chinese Peoples Liberat Army Gen Hosp, Dept Cardiol, Beijing, Peoples R China.
C3 Chinese People's Liberation Army General Hospital; Chinese People's
   Liberation Army General Hospital
RP Xu, P (corresponding author), 252 Hosp Chinese Peoples Liberat Army, Dept Cardiol, Baoding, Hebei, Peoples R China.
EM sarah511xp@163.com; liyangbsh@163.com; caoxb252@163.com
FU Medical Science Research Programme of the Chinese Army [CWS12J064];
   Medical Technology Project of the Chinese Army [BWS11J058]; Logistical
   Science Research Project of the Chinese Army [CBJ13J002]; National
   Natural Science Foundation of China [81870249]; National Key RAMP;D
   Programme of China [2017YFC0908700, 2017YFC0908703]
FX This study was supported by grants from the Medical Science Research
   Programme of the Chinese Army (CWS12J064), the Medical Technology
   Project of the Chinese Army (BWS11J058), the Logistical Science Research
   Project of the Chinese Army (CBJ13J002), the National Natural Science
   Foundation of China (81870249), and the National Key R&D Programme of
   China (2017YFC0908700 and 2017YFC0908703).
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NR 29
TC 5
Z9 7
U1 0
U2 15
PU CLINICS CARDIVE PUBL PTY LTD
PI DURBANVILLE
PA PO BOX 1013, DURBANVILLE, 7551, SOUTH AFRICA
SN 1995-1892
EI 1680-0745
J9 CARDIOVASC J AFR
JI Cardiovasc. J. Afr.
PD JAN-FEB
PY 2020
VL 31
IS 1
BP 25
EP 32
DI 10.5830/CVJA-2019-043
PG 8
WC Cardiac & Cardiovascular Systems
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology
GA KU2OK
UT WOS:000519547600007
PM 31647492
OA Green Submitted
DA 2026-05-27
ER

PT J
AU Zhang, ZD
   Yang, W
   Ma, F
   Ma, Q
   Zhang, B
   Zhang, YL
   Liu, YQ
   Liu, HX
   Hua, YW
AF Zhang, Zhandong
   Yang, Wei
   Ma, Fei
   Ma, Qi
   Zhang, Bin
   Zhang, Yonglei
   Liu, Yingqiang
   Liu, Hongxing
   Hua, Yawei
TI Enhancing the chemotherapy effect of Apatinib on gastric cancer by
   co-treating with salidroside to reprogram the tumor hypoxia
   micro-environment and induce cell apoptosis
SO DRUG DELIVERY
LA English
DT Article
DE drug-resistance; hypoxic microenvironment; nanoparticles; tumor
   targeting; drug delivery
ID ENDOTHELIAL GROWTH-FACTOR; FACTOR RECEPTOR 1; RESISTANCE;
   BIODISTRIBUTION; PROLIFERATION; CISPLATIN; OUTCOMES; PEPTIDE; PATHWAY;
   TRIAL
AB Hypoxic microenvironment commonly occurred in the solid tumors considerably decreases the chemosensitivity of cancer cells. Salidroside (Sal), the main active ingredient of Rhodiola rosea, was shown to be able of regulating the tumor hypoxia micro-environment and enhancing the chemotherapeutic efficacy of drug-resistant cancer. Therefore, in this study, the Sal was co-loaded with Apatinib (Apa) by the PLGA-based nanoparticles (NPs) to improve the chemosensitivity of gastric cancer cells. Additionally, to improve the drug delivery efficacy, the tumor-homing peptide (iVR1 peptides) was further decorated on the surface of NPs. The tumor targeting ability of the peptides-functionalized nanoparticles (iVR1-NPs-Apa/Sal) was evaluated by in vitro and in vivo experiments. As the obtained results revealed that the iVR1-NPs-Apa/Sal displayed excellent tumor affinity than the unmodified ones (NPs-Apa/Sal), which in turn resulted in more efficient of anti-proliferation of gastric cancer cells and anti-tumor effect in vivo. In addition, compared with the cells or tumor-bearing mice only treaded by monotherapy of Apa, the cells or mice received combinational treatment of Apa and Sal showed obvious lower rate of growth, invasion, and migration or tumor growth and progress. Underlying mechanisms were further investigated and it was revealed that the anti-gastric cancer effect of Apa was signally improved by Sal through down-regulation the proliferation factors and increase the pro-apoptotic genes, as well as reprograming the tumor hypoxia micro-environment. In a word, the study showed that the Sal was able of improving the chemosensitivity of gastric cancer to Apa and the iVR1-NPs-Apa/Sal was capable of realizing highly efficient of tumor-targeting drug delivery.
C1 [Zhang, Zhandong; Yang, Wei; Ma, Fei; Ma, Qi; Zhang, Bin; Zhang, Yonglei; Liu, Yingqiang; Liu, Hongxing; Hua, Yawei] Zhengzhou Univ, Affiliated Tumor Hosp, Dept Gen Surg, Henan Canc Hosp, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China.
C3 Zhengzhou University
RP Hua, YW (corresponding author), Zhengzhou Univ, Affiliated Tumor Hosp, Dept Gen Surg, Henan Canc Hosp, 127 Dongming Rd, Zhengzhou 450008, Henan, Peoples R China.
EM huayaweihenan@126.com
RI Liu, Yingqiang/GYR-0294-2022
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NR 32
TC 27
Z9 33
U1 0
U2 39
PU TAYLOR & FRANCIS LTD
PI ABINGDON
PA 2-4 PARK SQUARE, MILTON PARK, ABINGDON OR14 4RN, OXON, ENGLAND
SN 1071-7544
EI 1521-0464
J9 DRUG DELIV
JI Drug Deliv.
PD JAN 1
PY 2020
VL 27
IS 1
BP 691
EP 702
DI 10.1080/10717544.2020.1754528
PG 12
WC Pharmacology & Pharmacy
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Pharmacology & Pharmacy
GA LM9UA
UT WOS:000532591800001
PM 32397840
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Kolodziej, B
   Sugier, D
AF Kolodziej, Barbara
   Sugier, Danuta
TI INFLUENCE OF PLANTS AGE ON THE CHEMICAL COMPOSITION OF ROSEROOT
   (Rhodiola rosea L.)
SO ACTA SCIENTIARUM POLONORUM-HORTORUM CULTUS
LA English
DT Article
DE morphological parts; quality of raw material; phenylpropanoids and
   phenylethanoids content
ID BIOLOGICALLY-ACTIVE COMPOUNDS
AB Roseroot, Rhodiola rosea L. has been used in the traditional Asian, Scandinavian and Eastern European medicine for centuries as remedies for improvement of physical condition, treatment of anemia, depression, asthenia, impotence,. gastro-intestinal and nervous system disorders and also as a immunostimulant and anti-inflammatory agent. This valuable plant grows naturally in Himalayas, Altai, Alps and the Carpatian mountains. Roseroot raw material contains phenylethanoids (salidroside and p-tyrosol) and cinnamic glycosides known as phenylpropanoids (rosin, rosavin and rosarin), that are considered the most important active substances identified in raw material. The objective of this experiment was to compare the content of phenolic compounds (salidroside, p-tyrosol) and cinnamic glycosides (rosarin, rosavin and rosin) determined by HPLC method, from particular morphological parts (roots, rhizomes, and for the first time tips and above ground parts) of the raw material of R. rosea cultivated in Poland through seven following vegetation periods. In this study we found that significantly yearly increases in total phenylethanoids and phenylpropanoids concentrations occur with R. rosea grown in Poland. Rhizomes were characterized by highest amount of phenylpropanoids and phenylethanoids studied, in comparison to the other morphological parts of plants at the same age, whereas a certain amount of active substances were also found in the stems and leaves of Rhodiola rosea (on an average as twice as lower than in the under ground parts of plants). Thus, above ground parts of roseroot could be a potential source of phenylethanoids and phenylpropanoids for pharmacy. Roseroot harvested after only 3 year of vegetation contained significantly lower amounts of phenylethanoids and phenylpropanoids in under ground parts of plants than harvested after 4, 5 or 6 year. Since these phenolics and glycosides are the major active constituents of Rhodiola rosea, this change to an earlier harvest (before fourth or in appropriate cases in third year) may have an effect on the quality of the harvested raw material.
C1 [Kolodziej, Barbara; Sugier, Danuta] Univ Life Sci Lublin, PL-20950 Lublin, Poland.
C3 University of Life Sciences in Lublin
RP Kolodziej, B (corresponding author), Univ Life Sci Lublin, Dept Ind & Med Plants, 15 Akad Str, PL-20950 Lublin, Poland.
EM barbara.kolodziej@up.lublin.pl
OI Sugier, Danuta/0000-0002-0837-9751; Kolodziej,
   Barbara/0000-0002-3128-3926
FU Ministry of Science and Higher Education [N N310 448438]
FX The studies were financed by the Ministry of Science and Higher
   Education within grant No. N N310 448438
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NR 24
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U2 23
PU WYDAWNICTWO AKAD ROLNICZEJ W LUBLINIE
PI LUBLIN
PA UL AKADEMICKA 13, LUBLIN, 20-950, POLAND
SN 1644-0692
EI 2545-1405
J9 ACTA SCI POL-HORTORU
JI Acta Sci. Pol.-Hortorum Cultus
PY 2013
VL 12
IS 3
BP 147
EP 160
PG 14
WC Horticulture
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Agriculture
GA 247YA
UT WOS:000326659700014
DA 2026-05-27
ER

PT J
AU Nikolaichuk, H
   Choma, IM
   Morlock, GE
AF Nikolaichuk, Hanna
   Choma, Irena M.
   Morlock, Gertrud E.
TI Bioactivity Profiles on 15 Different Effect Mechanisms for 15 Golden
   Root Products via High-Performance Thin-Layer Chromatography, Planar
   Assays, and High-Resolution Mass Spectrometry
SO MOLECULES
LA English
DT Article
DE Rhodiola rosea; antibacterial; antimicrobial; enzyme inhibitor;
   antioxidant; genotoxin; estrogen; androgen; agonist; antagonist;
   endocrine activity; bioassay; biochemical assay; effect-directed
   analysis; HPTLC-EDA; HPTLC-HPLC-HESI-HRMS
ID INDUCED RAT MODEL; RHODIOLA-ROSEA; ALZHEIMERS-DISEASE; SALIDROSIDE
AB Planar chromatography has recently been combined with six different effect-directed assays for three golden root (Rhodiola rosea L.) samples. However, the profiles obtained showed an intense tailing, making zone differentiation impossible. The profiling was therefore improved to allow for the detection of individual bioactive compounds, and the range of samples was extended to 15 commercial golden root products. Further effect-directed assays were studied providing information on 15 different effect mechanisms, i.e., (1) tyrosinase, (2) acetylcholinesterase, (3) butyrylcholinesterase, (4) beta-glucuronidase, and (5) alpha-amylase inhibition, as well as endocrine activity via the triplex planar yeast antagonist-verified (6-8) estrogen or (9-11) androgen screen, (12) genotoxicity via the planar SOS-Umu-C bioassay, antimicrobial activity against (13) Gram-negative Aliivibrio fischeri and (14) Gram-positive Bacillus subtilis bacteria, and (15) antioxidative activity (DPPH center dot radical scavengers). Most of the golden root profiles obtained were characteristic, but some samples differed substantially. The United States Pharmacopeia reference product showed medium activity in most of the assays. The six most active compound zones were further characterized using high-resolution mass spectrometry, and the mass signals obtained were tentatively assigned to molecular formulae. In addition to confirming the known activities, this study is the first to report that golden root constituents inhibit butyrylcholinesterase (rosin was tentatively assigned), beta-glucuronidase (rosavin, rosarin, rosiridin, viridoside, and salidroside were tentatively assigned), and alpha-amylase (stearic acid and palmitic acid were tentatively assigned) and that they are genotoxic (hydroquinone was tentatively assigned) and are both agonistic and antagonistic endocrine active.
C1 [Nikolaichuk, Hanna; Morlock, Gertrud E.] Justus Liebig Univ Giessen, Inst Nutr Sci, Chair Food Sci, Heinrich Buff Ring 26-32, D-35392 Giessen, Germany.
   [Nikolaichuk, Hanna; Choma, Irena M.] Marie Curie Sklodowska Univ, Fac Chem, Dept Chromatog, Mar Curie Sklodowska Sq 3, PL-20031 Lublin, Poland.
   [Nikolaichuk, Hanna] Med Univ Lublin, Fac Biomed, Dept Bioanalyt, Jaczewskiego St 8b, PL-20090 Lublin, Poland.
C3 Justus Liebig University Giessen; Maria Curie-Sklodowska University;
   Medical University of Lublin
RP Morlock, GE (corresponding author), Justus Liebig Univ Giessen, Inst Nutr Sci, Chair Food Sci, Heinrich Buff Ring 26-32, D-35392 Giessen, Germany.
EM gertrud.morlock@ernaehrung.uni-giessen.de
RI Morlock, Gertrud/E-6343-2013; Choma, Irena/AAG-9790-2021
OI Morlock, Gertrud/0000-0001-9406-0351; Choma, Irena/0000-0002-6878-3748;
   Nikolaichuk, Hanna/0000-0001-6292-483X
FU International Doctorate Study in Chemistry at Maria Curie-Sklodowska
   University, Lublin, Poland; Deutsche Forschungsgemeinschaft (DFG, German
   Research Foundation) [INST 162/471-1 FUGG, INST 162/536-1 FUGG]
FX The study was performed during the 6-month research stay of H.N. at JLU
   Giessen, Germany, funded by the project International Doctorate Study in
   Chemistry at Maria Curie-Sklodowska University, Lublin, Poland.
   Instrumentation was partially funded by the Deutsche
   Forschungsgemeinschaft (DFG, German Research Foundation)-INST 162/471-1
   FUGG; INST 162/536-1 FUGG.
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NR 54
TC 9
Z9 9
U1 3
U2 25
PU MDPI
PI BASEL
PA MDPI AG, Grosspeteranlage 5, CH-4052 BASEL, SWITZERLAND
EI 1420-3049
J9 MOLECULES
JI Molecules
PD FEB
PY 2023
VL 28
IS 4
AR 1535
DI 10.3390/molecules28041535
PG 16
WC Biochemistry & Molecular Biology; Chemistry, Multidisciplinary
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Biochemistry & Molecular Biology; Chemistry
GA 9K2VG
UT WOS:000940728200001
PM 36838523
OA Green Submitted, gold
DA 2026-05-27
ER

PT J
AU Kosanovic, D
   Tian, X
   Pak, O
   Lai, YJ
   Hsieh, YL
   Seimetz, M
   Weissmann, N
   Schermuly, RT
   Dahal, BK
AF Kosanovic, Djuro
   Tian, Xia
   Pak, Oleg
   Lai, Ying-Ju
   Hsieh, Yi-Ling
   Seimetz, Michael
   Weissmann, Norbert
   Schermuly, Ralph Theo
   Dahal, Bhola Kumar
TI Rhodiola: an ordinary plant or a promising future therapy for
   pulmonary hypertension? a brief review
SO PULMONARY CIRCULATION
LA English
DT Review
DE Rhodiola; pulmonary hypertension; pulmonary vascular remodeling; Chinese
   medicine; salidroside
ID ARTERIAL-HYPERTENSION; PHENOLIC-COMPOUNDS; REACTIVE OXYGEN; ANTIOXIDANT;
   EXPRESSION; MANAGEMENT; INHIBITOR; ROSEA
AB Pulmonary hypertension (PH) is a chronic, complex, and progressive disease that eventuates in fatality. Research efforts over the past decades have resulted in therapeutic options that improve quality of life and prolong survival of patients, but they do not offer a cure. We propose a philosophical model that a disturbed balance of yin and yang results in pulmonary vascular remodeling, the hallmark of PH pathology. The model may be useful in exploring the wisdom of traditional Chinese medicine and incorporating it into mainstream PH research. In this context, the medicinal plant Rhodiola can be of profound interest owing to its variety of health-friendly attributes. Rhodiola has been shown to be beneficial in high-altitude-related symptoms and acute exacerbation of PH; moreover, improvement of PH has been demonstrated experimentally in chronically hypoxic rats. The beneficial effects of Rhodiola in PH may be attributable to its potential targeting of the signaling pathways, such as endothelin-1, nitric oxide, vascular endothelial growth factor, angiotensin-converting enzyme, nuclear factor kappa-B, tumor necrosis factor alpha, and interleukin-6. Alterations in these mediators are implicated in PH pathogenesis, the characteristics of which include chronic pulmonary vasoconstriction, vasoproliferation, and vascular inflammation. Salidroside, one of the compounds extracted from Rhodiola, has been found to provide therapeutic benefits in experimental PH. As the data are limited and the field is in its infancy, further studies including in-depth analysis of the therapeutic effects on various animal models of PH are desirable. We believe that future PH research should place an adequate and special emphasis on exploring and promoting the potential of traditional Chinese medicine, and to this end, the medicinal plant Rhodiola offers a promising field on which to embark.
C1 [Kosanovic, Djuro; Tian, Xia; Pak, Oleg; Seimetz, Michael; Weissmann, Norbert; Schermuly, Ralph Theo; Dahal, Bhola Kumar] Univ Giessen & Marburg Lung Ctr, Dept Internal Med, Giessen, Germany.
   [Lai, Ying-Ju] Chang Gung Univ, Coll Med, Dept Resp Therapy, Taoyuan, Taiwan.
   [Hsieh, Yi-Ling] Chang Gung Univ, Coll Med, Grad Inst Clin Med Sci, Taoyuan, Taiwan.
C3 Chang Gung University; Chang Gung University
RP Schermuly, RT (corresponding author), Univ Giessen & Marburg Lung Ctr, Justus Liebig Univ Aulweg 130, D-35392 Giessen, Germany.
EM ralph.schermuly@innere.med.uni-giessen.de
RI Kosanovic, Djuro/AAQ-7510-2021
OI Kosanovic, Djuro/0000-0002-7094-2269; Weissmann,
   Norbert/0000-0003-2675-3871; Hsieh, Yi-Ling/0000-0002-7929-5213;
   Schermuly, Ralph/0000-0002-5167-6970; Lai, Ying-Ju/0000-0001-9750-7649
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NR 47
TC 29
Z9 34
U1 1
U2 14
PU SAGE PUBLICATIONS INC
PI THOUSAND OAKS
PA 2455 TELLER RD, THOUSAND OAKS, CA 91320 USA
SN 2045-8932
EI 2045-8940
J9 PULM CIRC
JI Pulm. Circ.
PD SEP
PY 2013
VL 3
IS 3
BP 499
EP 506
DI 10.1086/674303
PG 8
WC Cardiac & Cardiovascular Systems; Respiratory System
WE Science Citation Index Expanded (SCI-EXPANDED)
SC Cardiovascular System & Cardiology; Respiratory System
GA V47WJ
UT WOS:000209981600005
PM 24618536
OA Bronze
DA 2026-05-27
ER

EF